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Principles of Immunology Transplantation Immunology 4/25/06
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Principles of Immunology Transplantation Immunology 4/25/06.

Dec 20, 2015

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Page 1: Principles of Immunology Transplantation Immunology 4/25/06.

Principles of Immunology

Transplantation Immunology4/25/06

Page 2: Principles of Immunology Transplantation Immunology 4/25/06.

Word/Terms List

Allograft Autograft GVH HLA Isograft MHC Xenograft

Page 3: Principles of Immunology Transplantation Immunology 4/25/06.

Transplantation Immunology

Types of transplants

Autograft Isograft Allograft Xenograft

Page 4: Principles of Immunology Transplantation Immunology 4/25/06.

Graft Rejection

First set

Second set

Analogous to primary and secondary antibody response

Page 5: Principles of Immunology Transplantation Immunology 4/25/06.
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Causes of Rejection

MHC – HLA antigens in humans

Haplotypes

DTH reaction

Cell-mediated immunity

Page 8: Principles of Immunology Transplantation Immunology 4/25/06.

Stages of Rejection

Sensitization-

APCs from donor APCs from host

“Passenger leukocytes”

CD8 and CD4 both react

Page 9: Principles of Immunology Transplantation Immunology 4/25/06.

Stages of Rejection Effector stage

C mediated Ab response

ADCC

CTLs

DTH

Page 10: Principles of Immunology Transplantation Immunology 4/25/06.
Page 11: Principles of Immunology Transplantation Immunology 4/25/06.

Compatibility Tests

ABO Microcytotoxicity

Pre existing Ab C mediated

Mixed lymphocyte reaction Measures T helper activation Uses radioactive thymidine as

determinant

Page 12: Principles of Immunology Transplantation Immunology 4/25/06.
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Clinical Types of Rejection Hyperacute

<24 hours Preexisting Ab ABO mismatch

Acute Weeks Macrophages Cytokines

Chronic Months or longer Humoral and cell-mediated

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General Immunosupression

Mitotic Inhibitors Affects all rapidly dividing cells

Steroids Anti inflammatory

Cytokine inhibitors Inhibits T cell proliferation

Page 18: Principles of Immunology Transplantation Immunology 4/25/06.

Specific Immunosupression

Monoclonal Ab Anti CD3

Blocking co stimulation CTLA injection

Page 19: Principles of Immunology Transplantation Immunology 4/25/06.

Immune Tolerance

Non immunogenic tissue

Privileged sites

Induced tolerance