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Presentation1 Chitosan Final

Feb 04, 2018

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    By :Hermawan Judawisastra, J.B.A Nordin, B. Sunendar

    Material Science and Engineering Research GroupFaculty of Mechanical and Aerospace Engineering - ITB

    Bandung, I !" ESIA

    #

    1 st International Conference on Materials Engineering(ICME) and 3 rd AUN/SEED-Net Regional Conference on

    Materials (RCM) 2-3 e!r"ar# 2$11% &og#a'arta%Indonesia

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    Increase of de$and for hu$anprosthetic de%ices & 'ody transplant

    (ure titaniu$ and Ti)*Al)+ idelyused .e/cellent 'ioco$pati'ility, lo 0oung1s $odulus, and high toughness2

    $ay release har$ful $etal particles . and Al ions2

    3ydro/yapatite .4a 5 .(" +26 ."32 coating.sta'ility, 'ioco$pati'ility2

    %ery 'rittle and easy to 7a8e out duringi$plantation

    6# st I4ME & 9 rd R4M ) 0ogya8arta, Fe'ruary 6nd ) 9rd , 6 ##

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    43IT"SA :

    ; A'undant in nature; Bioacti%e (roperties

    .anti'acterial, 'iodegrada'le, non-to/ic, andthe a'ility to attract and pro$ote 'one cellgro th and organi

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    +

    In%estigate e>ects of %arying 4hitosanM on:

    ; Bioactivity of Chitosan Membranes (L Mw and HMw!

    ; Adhesiveness of Chitosan Coatin"s on #i $A% &'

    ; Bioactivity of Chitosans A atite Coatin" on #i$A% &'

    # st I4ME & 9 rd R4M ) 0ogya8arta, Fe'ruary 6nd ) 9rd , 6 ##

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    5# st I4ME & 9 rd R4M ) 0ogya8arta, Fe'ruary 6nd ) 9rd , 6 ##

    [email protected]

    4hitosan ?o Mchitosan

    3igh M 4hitosan

    !eacytelation

    5- 5C D 5C

    iscosity 6 ) 6 cps -6 cp

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    *

    Bioactivity of Chitosan Membrane

    Adhesiveness of Chitosan Coatin"

    # st I4ME & 9 rd R4M ) 0ogya8arta, Fe'ruary 6nd ) 9rd , 6 ##

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    Bioactivity of Chitosan A atite Coatin"

    # st I4ME & 9 rd R4M ) 0ogya8arta, Fe'ruary 6nd ) 9rd , 6 ##

    sa$ple of Ti-*Al-+ coated ith 3igh M chitosan .Ti-3-4s2

    ; Ti -3-4s -3-A; Ti -3-4s -?-A

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    a%enu$'er

    .c$-#2

    Assign$ent

    day # day days

    a%e

    nu$'er.c$-#2

    Intensity

    a%enu$'er.c$-#2

    Intensity

    a%enu$'er.c$-#2

    Intensity

    6 6 36, 4363-4s 6 # = = 6 # = *= 95 6 # = #+=6?-4s 6 # = =##+ 6 += =## 6 # = +=

    #9 94-"-4H 4-

    439

    3-4s #9 *= #*= #9 = #5= 9 #9 = 6 = #?-4s #96*= 6+=65 #9 = =9+ #9 = 6 =*#

    Crysta%%inity )nde*H Cs + $- $$

    L Cs & // 01+

    FTIR Spectroscopy results

    ; The crystallinity inde/ .4rI2 of the sa$ples ere calculated fro$ the ratio of a'sor'a at #9 6 and 6 6 c$-# .special pea8s for chitosan2=

    ; Sharp 4rI increase of ?-4s indicates its higher co$pati'ility in o8u'o1s solution co$to 3-4s

    # st I4ME & 9 rd R4M ) 0ogya8arta, Fe'ruary 6nd ) 9rd , 6 ##

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    FTIR Spectroscopy results

    # st I4ME & 9 rd R4M ) 0ogya8arta, Fe'ruary 6nd ) 9rd , 6 ##

    3-4s 'efore and after i$$ersion ?-4s 'efore and after i$$ersion

    ; For 'ioacti%e product, appearance of phosphate group pea8s=; After i$$ersion: (ea8s of ?-4s are shaper after co$pared to 3-4s pea8s=; The high increased of ?-4s 4rI: the for$ation of poor crystalline phosphate=

    ?-4s is $ore 'ioacti%e co$pared to 3-4s

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    SEM results

    #

    Before i$$ersion After days i$$ersion

    3-M 4s

    ?-M4s

    More crystalline

    More 4a4" 1 granules# st I4ME & 9 rd R4M ) 0ogya8arta, Fe'ruary 6nd ) 9rd , 6 ##

    ?-4s is $ore 'ioacti%e co$pared to 3-4s=

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    SEM e/a$ination of =68gf load Micro%ic8ers indentatio

    Ti-3-4s.3igh M 2

    Ti-?-4s.?o M 2

    # st I4ME & 9 rd R4M ) 0ogya8arta, Fe'ruary 6nd ) 9rd , 6 ##

    Ti-3-4s is 'etter for Ti-*Al-+ coating than Ti-?-4s=

    ; locali

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    #6

    Apatite , Ti"6 Apatite , Ti"6

    3igh M ?o M

    JR! E/a$ination

    ; E/posure of Ti"6 due to 4s-Apatite 7a8ing ; Increase of apatite indication of cellsa'sorption and osteo'last generation

    # st I4ME & 9 rd R4M ) 0ogya8arta, Fe'ruary 6nd ) 9rd , 6 ##

    Ti -3-4s -?-A Ti -3-4s -3-A

    Ti -3-4s -L-A is $ore 'io- acti%e Ti -3-4s -H -A

    Hi"h Mw

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    SEM e/a$ination .'efore i$$ersion2

    Finer Apatite $olecules due toeasier interaction ith "3- and 36

    # st I4ME & 9 rd R4M ) 0ogya8arta, Fe'ruary 6nd ) 9rd , 6 ##

    3igh M ?o M Ti -3-4s -?-A Ti -3-4s -3-A

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    SEM e/a$ination .after i$$ersion23igh M ?o M Reference

    ; 3-4s- H A e/hi'its ho$ogeneously gro n apatite agglo$eration=; 3-4s- L A sho s e%idence of ell for$ed apatite gro th, si$ilar to referen

    and $ore li8ely to generate osteo'last=

    # st I4ME & 9 rd R4M ) 0ogya8arta, Fe'ruary 6nd ) 9rd , 6 ##

    Ti -3-4s -?-A Ti -3-4s -3-A

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    ?o $olecular eight 4hitosan .?-4s2 is $ore'ioacti%e than high $olecular eight 4hitosan.3-4s2=

    3igh M chitosan coating on Ti-*Al-+ .Ti-3-4s2is $ore adhesi%e co$pare to lo M chitosanon Ti-*Al-+ .Ti-?-4s2 as Ti-3-4s sho ed $oreductile fracture $ode=

    4oated Ti-3-4s ith lo M chitosan andapatite .Ti-3-4s-?-A2 is $ore 'ioacti%e co$pareto Ti-3-4s ith high M and apatite .Ti-3-4s-3-A2= This type of coating layer also successfullyeli$inates Al and release=

    #*# st I4ME & 9 rd R4M ) 0ogya8arta, Fe'ruary 6nd ) 9rd , 6 ##

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    17/17## st I4ME & 9 rd R4M ) 0 g 8 t F ' 6 d ) 9 d 6 ##

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