Preparation and Evaluation of an Inactivated Multi- Strain PRRS Vaccine Made with Viruses Isolated from Vietnam Central Vietnam Veterinary Institute This study is presented by Hung Vu Khac, Ph.D. of the Central Vietnam Veterinarian Institute in Nha Trang, Vietnam.
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Preparation and Evaluation of an Inactivated Multi-Strain PRRS Vaccine Made with Viruses Isolated from Vietnam Central Vietnam Veterinary Institute This.
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Preparation and Evaluation of an
Inactivated Multi-Strain PRRS Vaccine
Made with Viruses Isolated from
Vietnam
Central Vietnam Veterinary Institute
This study is presented by Hung Vu Khac, Ph.D. of the Central Vietnam Veterinarian Institute in Nha Trang, Vietnam.
PRRSV causes severe economic loss in swine production worldwide including Vietnam.
Central Vietnam Veterinary Institute (CVVI) has reviewed possible options of the PRRS vaccine to control the disease nationwide.
Swine producers and veterinarians have expressed concerns over current imported vaccines due to immunological variation among PRRS viruses for cross-protection and inherent high mutation rates of the virus.
Representing anti-PRRSV envelop proteins antibodies in pig serum, protective antibodies
Representing anti-PRRSV N-proteins antibodies in pig serum, non-protective antibodies
6. Evaluate the Trial Batch of Vaccine
Summary
1. A trial batch of vaccine was made with 6 antigen extracts from 6 PRRSV
strains based on MJPRRS® Technology.
2. The trial batch met the requirements of sterility and safety tests.
3. The vaccinated group showed
1) Faster response on ELISA and body temperature after challenged.
2) 10 times lower virus titer compared to the unvaccinated group.
3) Higher and faster protective antibody formation shown by Western blot.
4) These are indications of the early on-set of an immune response due to
“memory cell effect” developed from the vaccine.
4. The lack of weight difference in the trials may be due to the lack of secondary
infections as in a field environment.
Comments
• Efficacy test results are quite well matched to the study presented at AASV-2012 by Dr. Mark Wagner, “Evaluation of the efficacy of one dose of autogenous MJPRRS ® vaccine in nursery pigs”