Pediatric Formulations Obesity and Breast Cancer Space,Time … · 2013-11-21 · munity.- Arginine Metabolism, a Major Pathway for the Suppressive Function of Myeloid-derived Suppressor

News 12/2013 Biomedicine

17

D. Bar-Shalom, University of Copenhagen, , Denmark; K. Rose, klausrose Consulting, Riehen, Switzerland (Eds)

Pediatric FormulationsA Roadmap

Contents Pediatric Development: Anatomy.- Age, Weight, Body Surface and Stature, Organ Development.- Pediatric Development: Physiology. Enzymes, Drug Metabolism, Pharmacokinetics and Pharmacodynamics.- Pediatric Development – Gastrointestinal.- How to Estimate the Dose to be Given for the First Time to Pediatric Patients.- The Clinical Relevance of Pediatric Formulations.- General Considerations for Pediatric Oral Drug Formulation.- Orosensory Perception.- Flavor Is Not Just Taste: Taste Concealing.- Liquid Formula-tions.- Paediatric Solid Formulations.- Semi-Solid Formulations.- The Challenge of Automated Compounding.- Pediatric Formulations in Clini-cal Testing and the Challenge of Final Market Formulation.- Buccal/Sublingual Drug Delivery for the Paediatric Population.- Topical and Trans-dermal.- Parenteral Liquids for Intravenous and Transdermal Use.- The Challenges of Paediatric Pulmonary Drug Delivery.- Nasal, Ocular and Otic Drug Delivery.- Rectal Drug Delivery.- In-traosseous Infusions in Infants and Neonates.- Compounding for Children – The Compounding Pharmacist.- Food Ingredients.- Excipients and Active Pharmaceutical Ingredients (APIs).- Clini-cal Testing in Children.- Pediatric Formulations and Dosage Forms and Future Opportunities: Impact of Regulations in the United States and Implementation of Quality by Design.- Pediatric Pharmaceutical Legislation and its impact on Adult and Pediatric Drug Development: The EU Regulatory View. [...]

Fields of interestPharmaceutical Sciences/Technology; Pharmacy; Pediatrics

Target groupsResearch

Discount groupProfessional Non-Medical

Due January 2014

2014. X, 285 p. 67 illus., 37 in color. (AAPS Advances in the Pharmaceutical Sciences Series, Volume 11) Hardcover7 $189.00ISBN 978-1-4899-8010-6

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K. A. Brown, Prince Henry’s Institute, Clayton, VIC, Australia; E. R. Simpson, Prince Henry’s Institute, Clayton, VIC, Australia

Obesity and Breast CancerThe Role of Dysregulated Estrogen Metabolism

Obesity is a risk factor for breast cancer in older women. A number of adipose-derived and obesity-related factors have been shown to affect tumour cell growth. These include adipokines, insulin, IGF-1 and oestrogens. The majority of obesity-related postmenopausal breast cancers are oestrogen-dependent. Since the ovaries no longer produce oestrogens after menopause, and that cir-culating levels are negligible, it is evident that it is the oestrogens produced locally within the breast adipose that are responsible for the increased growth of breast cancer cells. Aromatase is the enzyme that converts androgens into oestrogens and its regulation is dependent on the activity of a number of tissue-specific promoters. Targeting oestrogen biosynthesis in obesity may be useful for the prevention of breast cancer.

Features 7 Features cutting-edge aromatase re-search 7 Explores the application of novel thera-pies to inhibit aromatase in the breast 7 Dis-cusses the connection between obesity and breast cancer in older women

Contents Introduction.- Estrogens, adiposity and the menopause.- The link between obesity and breast cancer: Epidemiological evidence.- Adipose-derived and obesity-related factors and breast cancer.- Estrogen biosynthesis.- Therapies aimed at breaking the linkage between obesity and breast cancer.- Conclusions.

Fields of interestCancer Research; Metabolic Diseases; Enzymology



Due December 2013

2014. VII, 54 p. 9 illus., 7 in color. (SpringerBriefs in Cancer Research) Softcover7 $54.99ISBN 978-1-4899-8001-4

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D. Derdikman, Technion- Israel Institute of Technology, Haifa, Israel; J. J. Knierim, John Hopkins University The Zanvyl Krieger Mind/Brain Institute, Baltimore, MD, USA (Eds)

Space,Time and Memory in the Hippocampal FormationThe discovery of new cell types, such as grid and time cells, in the hippocampus has been accompa-nied by major anatomical and theoretical insights in the recent years.

Features 7 Provides current information about recent ad-vances in the hippocampal research field 7 De-scribes in a structured way information flow from pre-hippocampal areas to processing and read out 7 Depicts the newest discoveries in this field like time cells, grid cells, boundary cells, sequences and nonspatial inputs

Contents Hippocampal inputs. Grid cells and boundary cells .- LEC and objects / external-information.- Peri/postrhinal vs. subicular complex, Retro-splenial cortex.- HD cells.- Modulatory inputs. Hippocampal processing. Remapping and context encoding.- Hippocampal subregions (transverse, longitudinal axes).- Look-ahead (VTE, replay, preplay, nonlocal representation).- Theta and oscillations (oscillatory interference, phase coding, phase precession).- Splitters, cells that remap to reflect the structure of the task at hand.- Time cells.- Neuroethological aspects (Humans, Primates, Bats). Hippocampal readout. Prefrontal interactions.- Striatal interactions.- Amygdala interactions.- Cerebellar interactions.- Parietal interactions.-

Fields of interestNeurosciences; Neurobiology; Behavioural Sci-ences



Due January 2014

2014. IV, 578 p. 80 illus., 65 in color. Hardcover7 $209.00ISBN 978-3-7091-1291-5

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www.springer.com/978-1-4899-8010-6



Biomedicine springer.com/NEWSonline

18

New SeriesNeglected Tropical DiseasesSeries editor: P. Hotez

This book series publishes contributions from individuals engaged in any of the fields related to neglected diseases clearly connected with their exceptional status as neglected. Specific focus of each title lies on the discussion of relevant issues in particular geographic areas of the world. Each volume of the series deals with the unique situ-ation of one region and is built up by a team of authors lead by an expert for the geographic area discussed. This series provides a forum for wealthy discussion on the topic of neglected infectious diseases with a clear focus on basic scientific top-ics, clinically relevant issues as well as policy issues associated with the area. Topics to be covered: detection, diagnosis, monitoring, vaccine and drug development, new treatments, translational research (link basic research and health system research), clinical aspects, epidemiology, develop-ment of new surveillance and control strategies, public health/health policy issues.

C. Franco-Paredes, Phoebe Putney Memorial Hospital, Albany, Georgia (Ed)

Neglected Tropical Diseases - Latin AmericaThe neglected tropical diseases (NTDs) represent some of the most common infections of the poor-est people living in Latin American and Caribbean (LAC). Because they primarily afflict the poor as well as selected indigenous populations and people of African descent, the NTDs in LAC are largely forgotten diseases. Yet, their collective disease burden may exceed better known conditions such as of HIV/AIDS, tuberculosis, or malaria. Based on their prevalence and healthy life years lost from disability, hookworm infection, other soil-trans-mitted helminth infections and Chagas disease are the most important NTDs in LAC, followed by dengue, schistosomiasis, leishmaniasis, trachoma, leprosy, and lymphatic filariasis.

Features 7 First volume on this topic with a specific focus on the special situation in Latin America 7 Writ-ten by dedicated experts in parasitology and infec-tious disease in this part of the world 7 Each chapter deals with a single major disease, focus-sing on disease burden, major manifestation and approaches to control and elimination of NTDs in Latin America

Contents General Introduction.- Hookworm.- Ascariasis, Toxocariasis, and Trichuriasis.- Strongyloidiasis (subsection on HTLV-1).- Lymphatic Filariasis and Onchocerciasis.- Schistosomiasis.- Leishman-iasis.- Amebiasis.- Chagas disease.- Dengue.- Lep-tospirosis.- Leprosy.- Treponematoses: Yaws and Non-Venereal Syphilis.- Plasmodium vivax.- Bar-tonelosis and NTDs for which no data is available.

Fields of interestParasitology; Infectious Diseases; Tropical Medi-cine



Due December 2014

2015. Approx. 300 p. 30 illus. in color. (Neglected Tropical Diseases) Hardcover7 approx. $209.00ISBN 978-3-7091-1421-6

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D. I. Gabrilovich, The Wistar Institute, Philadelphia, PA, USA; A. A. Hurwitz, N Potomac, MD, USA (Eds)

Tumor-Induced Immune SuppressionMechanisms and Therapeutic Reversal

Contents Preface.- Regulatory T Cells and Cancer.- Th17 cells in cancer.- Mast cells and immune response in cancer.- Myeloid-Derived Suppressor Cells in Tumor-Induced T-Cell Suppression and Tolerance.- Immunobiology of Dendritic Cells in Cancer.- Macrophages and Tumor Develop-ment.- Angiogenesis and Immune Suppression in Cancer.- Tim-3 Regulation of Cancer Immu-nity.- Transcriptional Regulation of Dendritic Cells in The Tumor Microenvironment.- S100A9, Inflammation, and Regulation of Immune Suppression in Cancer.- IDO in Inflammatory Programming and Immune Suppression in Can-cer.- Defining the Fate and Function of Effector T cells through Galectin-1 – Galectin-1 Ligand Binding Interactions: Implications in Tumor Im-munity.- Arginine Metabolism, a Major Pathway for the Suppressive Function of Myeloid-derived Suppressor Cells.- The Hypoxia-Adenosinergic Immunosuppression and Redirection of Immune Response in Tumor Microenvironment.- Molecu-lar Pathways in Antigen Presenting Cells Involved in the Induction of Antigen-Specific T-Cell Tolerance.- Overcoming Immune Suppression: Therapeutic Strategies Targeting T-Cell Function in Cancer.- Index.

Fields of interestCancer Research; Immunology; Medical Micro-biology



Due February 2014

2nd ed. 2014. X, 530 p. 38 illus., 34 in color. Hardcover7 $239.00ISBN 978-1-4899-8055-7

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19

P. Gopalakrishnakone, National University of Singapore, Singapore, Singapore (Ed)

ToxinologyClinical Toxinology

Contents Animal Toxin Envenomation in South Cone of America.- Antisera.- Bees and Wasp Envenom-ation.- Centipede Venom I.- Centipede Venom II.- Clinical Uses of Snake Antivenoms.- Com-plications of Hematotoxic Snake Bites in India.- Developing Snake Antivenom Sera by Genetic Immnization: A Review.- Disability and Impair-ment Following Snakebite in Africa.- Diversity and Distribution of the Medically Important Snakes of India.- Envenomations by Exotic Snakes and Other Venomous Pets.- Envenomations, Snakes, Jelly Fish.- Epidemiology of Snake Enven-omation in Taiwan.- Food Poisoning in Bangla-desh.- Haematoxic Snake Bites in India.- Histori-cal Review (of Snake Venom).- Management of Snake Envenomation in Taiwan.- Mushroom Poisoning.- Natural Toxin . [...]

Fields of interestBiomedicine general; Pharmacology/Toxicology; Pharmaceutical Sciences/Technology



Due October 2014

Print

2015. 550 p. 30 illus., 15 in color. (Handbook of Toxinology, Volume 2) 7 $379.00ISBN 978-94-007-6385-2

9<HTUELA=hgdifc> eReference

2015. 7 $379.00ISBN 978-94-007-6386-9

9<HTUELA=hgdigj> Print + eReference

2015. 550 p. 30 illus., 15 in color. (Handbook of Toxinology, Volume 2) 7 $469.00ISBN 978-94-007-6387-6

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M. Hayat, Kean University, Room 213, Library Building, Union, NJ, USA (Ed)

Stem Cells and Cancer Stem Cells, Volume 12Therapeutic Applications in Disease and Injury

Contents Preface.- I Cancer stem cells.- Histamine in the neural and cancer stem cell niches.- Emerging concepts of stem cell organization in the normal lung and in lung cancer. II Pluripotent stem cells.- Differentiation of dendritic cells from human induced pluripotent stem cells.- Molecular mecha-nisms underlying human somatic cell repro-gramming to generate induced pluripotent stem cells.- Induced pluripotent stem cells differentiate into functional cardiomyocytes.- Characteristics of satellite cells and multipotent adult stem cells in the skeletal muscle. III Dendritic cells.- Notch signaling in differentiation and function of dendritic cells.- Suppression of differentiation and maturation of dendritic cells: stem cells from different sources vary in their effect.- Hypertensive emergencies in children after stem cell transplan-tation: care in selecting hypotensive drugs.- Decel-lularized stem cell martix: a novel approach for autologous chondrocyte implantation cartilage repair.- Overcoming radioresistance of lung cancer stem cells. IV Regenerative medicine. - Phenotypic correction of murine hemophilia a using cell-based therapy.- Improved renal revascularization outcomes in pigs using stem cells.- Generation of autologous multipotent endothelial-like cells from lipoaspirates of human adipose-derived stem cells and polymer microarrays technology: potential cardiovascular regeneration.- Adipose-derived stem cells as a novel tool for future regenerative medicine.- Repairing the stroke-damaged brain: from neural stem cells to tissue engineering. [...]

Fields of interestCancer Research; Life Sciences, general; Oncology

Target groupsProfessional/practitioner


Due January 2014

2014. Approx. 600 p. 31 illus., 25 in color. (Stem Cells and Cancer Stem Cells, Volume 12) Hardcover7 $239.00ISBN 978-94-017-8031-5

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K. J. Hertel, University of California, Irvine, CA, USA (Ed)

Spliceosomal Pre-mRNA SplicingMethods and Protocols

Contents The Pre-mRNA Splicing Reaction.- Diversity and Evolution of Spliceosomal Systems.- Mecha-nisms of Spliceosomal Assembly.- Alternative Pre-mRNA Splicing.- Regulation of Alternative Pre-mRNA Splicing.- Introduction to Co-Tran-scriptional RNA Splicing.- Chromatin and Splic-ing.- Preparation of Splicing Competent Nuclear Extracts.- Preparation of Yeast Whole Cell Splicing Extract.- Efficient Splinted Ligation of Synthetic RNA Using RNA Ligase.- In Vitro Assay of Pre-mRNA Splicing in Mammalian Nuclear Extract.- Kinetic Analysis of In Vitro Pre-mRNA Splicing in HeLa Nuclear Extract.- In Vitro Systems for Coupling RNAP II Transcription to Splicing and Polyadenylation.- Isolation and Accumulation of Spliceosomal Assembly Intermediates.- Comple-mentation of U4 snRNA in S. cerevisiae Splicing Extracts for Biochemical Studies of snRNP Assem-bly and Function.- Expression and Purification of Splicing Proteins from Mammalian Cells.- Single Molecule Approaches for Studying Spliceosome Assembly and Catalysis.- Cell-Based Splicing of Minigenes.- Quantifying the Ratio of Spliceo-some Components Assembled on Pre-mRNA.- Antisense Methods to Modulate Pre-mRNA Splicing.- Using Yeast Genetics to Study Splicing Mechanisms.- Medium Throughput Analysis of Alternative Splicing by Fluorescently Labeled RT-PCR.- Chromatin Immunoprecipitation Ap-proaches to Determine Co-Transcriptional Nature of Splicing.- Computational Approaches to Mine Publicly Available Databases. [...]

Field of interestHuman Genetics



Due April 2014

2014. 440 p. 67 illus., 31 in color. (Methods in Molecular Biology, Volume 1126) Hardcover7 $139.00ISBN 978-1-62703-979-6

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20

JIMD ReportsG. Brown, E. Morava (Eds), K. M. Gibson, Editor-in-chief: J. Zschocke, Managing editor: V. Peters

Volume 12

J. Zschocke, Medical University Innsbruck, Innsbruck, Austria; K. M. Gibson, Washington State University Clinical Pharmacology, Pullman, WA, USA; G. Brown, University of Oxford, Oxford, UK; E. Morava, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands; V. Peters, Center for Child and Adolescent Medicine Heidelberg University Hospital, Heidelberg, Germany (Eds)

JIMD Reports - Case and Research Reports, Volume 12JIMD Reports publishes case and short re-search reports in the area of inherited metabolic disorders. Case reports highlight some unusual or previously unrecorded feature relevant to the disorder, or serve as an important reminder of clinical or biochemical features of a Mendelian disorder.

Features 7 Unique collection of case and research reports on rare metabolic disorders 7 Contains unusual or previously unrecorded features relevant to metabolic disorders 7 All contributions rigor-ously peer-reviewed

Contents Different case studies.

Fields of interestHuman Genetics; Metabolic Diseases; Pediatrics



Due December 2013

2013. Approx. 150 p. Softcover7 $139.00ISBN 978-3-319-03460-7

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S. Li, J. Cutrera, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA; R. Heller, Old Dominion University Frank Reidy Ctr for Bioelectrics, Norfolk, VA, USA; J. Teissie, IPBS CNR, Toulouse, France (Eds)

Electroporation ProtocolsPreclinical and Clinical Gene Medicine

Contents Electroporation-Based Gene Therapy: Recent Evo-lution in the Mechanism Description and Tech-nology Developments.- Electropermeabilization of the Cell Membrane.- The Impact of Non-Electrical Factors on Electrical Gene Transfer.- Electro-poration Formulation for Cell Therapy.- Short-Fragment DNA-Mediated in Vivo DNA Electro-poration Delivery.- Gold Nanoparticle-Enhanced Electroporation for Leukemia Cell Transfection.- SiRNA Delivery via Electropulsation: A Review of the Basic Processes.- Continuous Cell Electro-poration for Efficient DNA and siRNA Delivery Based on Laminar Microfluidic Chips.- Electro-poration of siRNA into Mouse Bone Marrow-Derived Macrophages and Dendritic Cells.- Direct Imaging of siRNA Electrotransfer at the Single Cell Level.- Electroporation-Mediated siRNA Delivery into Tumors.- Substrate-Mediated, High Efficiency siRNA Electroporation.- Intradermal Electroporation of RNA.- Delivery of DNA into the Central Nervous System via Electroporation.- DNA Delivery in Adult Mouse Eyes: An Update with Corneal Outcomes.- Delivery of Plasmid DNA into Developing Rat Teeth by Electropora-tion.- Electroporation-Mediated Gene Delivery to the Lungs.- Electroporation-Mediated Delivery of Genes in Rodent Models of Lung Contusion.- In Vivo Electroporation-Mediated Gene Delivery to the Beating Heart.- Managing Local Swelling Following Intratumoral Electro-Chemo-Gene Therapy.- Gene Electrotransfer in Clinical Trials. [...]

Fields of interestHuman Genetics; Gene Expression



Due January 2014

2nd ed. 2014. XII, 392 p. 72 illus., 24 in color. (Methods in Molecular Biology, Volume 1121) Hardcover7 $139.00ISBN 978-1-4614-9631-1

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M. A. McDowell, University of Notre Dame, Notre Dame, IN, USA; S. Rafati, Pasteur Institute of Iran, Tehran, Iran (Eds)

Neglected Tropical Diseases - Middle East and North AfricaThe Middle East and North Africa (MENA) is highly endemic for several neglected tropical diseases (NTDs), including viral, bacterial, proto-zoan, and helminth infections. This new volume covers the most prevalent NTDs found in about 22 MENA countries emphasizing the disease burden, clinical manifestations and control approaches. Each individual chapter deals with one specific disease and is written by a group of experts on that topic.

Features 7 Focuses on region specific topics of neglected tropical diseases in an economically diverse region 7 Individual chapters are authored by teams of experts for the topic 7 Includes an extensive discussion on disease burden, clinical manifestation and control approaches for indi-vidual diseases

Contents Soil-transmitted helminthes: ascariasis, trichu-riasis, and hookworms.- Schistosomiasis.- Fasio-liasis.- Trachoma.- Cutaneous Leishmaniasis.- Visceral Leishmaniasis.- Leprosy.- Hemorraghic Fevers.- Brucellosis.- Toxplasmosis.- Rabies.

Fields of interestParasitology; Infectious Diseases; Tropical Medi-cine



Due June 2014

2014. Approx. 300 p. 50 illus. in color. (Neglected Tropical Diseases) Hardcover7 approx. $189.00ISBN 978-3-7091-1612-8

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21

V. Ossipow, University of Geneva, Geneva, Switzerland; N. Fischer, NovImmune SA, Plan-les-Ouates, Switzerland (Eds)

Monoclonal AntibodiesMethods and Protocols

Contents Antigen Production for Monoclonal Antibody Generation.- Method for the Generation of Antibodies Specific for Site- and Post-translational Modifications.- Immunization, Hybridoma Gen-eration and Selection for Monoclonal Antibody Production.- Hybridoma Technology for the Generation of Rodent mAbs via Classical Fusion.- Generation of Rabbit Monoclonal Antibodies.- Screening Hybridomas for Cell Surface Antigens by High-throughput Homogenous Assay and Flow Cytometry.- Screening and Subcloning of High Producer Transfectomas using Semi-solid Media and Automated Colony Picker.- Design and Gen-eration of Synthetic Antibody Libraries for Phage Display.- Selection and Screening using Antibody Phage Display Libraries.- Yeast Surface Display for Antibody Isolation: Library Construction, Library Screening and Affinity Maturation.- Human B Cell Immortalization for Monoclonal Antibody Pro-duction.- Using Next-generation Sequencing for Discovery of High-frequency Monoclonal Anti-bodies in the Variable Gene Repertoires from Im-munized Mice.- Cloning, Reformatting and Small Scale Expression of Monoclonal Antibody Isolated from Mouse, Rat or Hamster Hybridoma.- Clon-ing of Recombinant Monoclonal Antibodies from Hybridomas in a Single Mammalian Expression Plasmid.- Monoclonal Antibody Purification by Ceramic Hydroxyapatite Chromatography.- Rapid Purification of Monoclonal Antibodies using Magnetic Microspheres.- Generation of Cell Lines for Monoclonal Antibody Production.- Expres-sion and Purification of Recombinant Antibody Formats and Antibody Fusion Proteins. [...]

Fields of interestImmunology; Laboratory Medicine; Antibodies



Due February 2014

2nd ed. 2014. 500 p. 114 illus., 34 in color. (Methods in Molecular Biology, Volume 1131) Hardcover7 $139.00ISBN 978-1-62703-991-8

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J. Peltola, Tampere University Hospital, Tampere, Finland

Clinical Management of Partial-Onset Seizures in EpilepsyWhile tonic-clonic seizures are the most com-monly recognized, approximately 60% of patients with epilepsy actually have partial-onset seizures, with one side of the brain being affected. While clinicians regularly see patients with partial-onset seizures, in both the community or office setting, it is often challenging to determine what the type of epilepsy is being experienced and which treatment should be administered. Written by a Dr Jukka Peltola, a renowned key thought leader, this concise high-quality pocket-sized book will be aimed at educating non-specialists how to accu-rately diagnose and classify partial-onset seizures, with a special focus on currently available and emerging treatments.

Features 7 Concise pocket book designed to support phy-sicians and neurologists in their day-to-day prac-tice 7 Written by a leading thought leader and developed using the latest clinical evidence and guidelines 7 High quality full-color supportive illustrations, tables, and graphs enable complicated concepts to be made clear to readers with different levels of background understanding

Contents Introduction to partial-onset epilepsy.-Definition and classification of epileptic seizures.-Diagnosis and prognosis of epileptic syndromes.-Treatment options and long-term management.

Fields of interestNeurosciences; Medicine/Public Health, general; Pharmacotherapy



Due March 2014

2014. Approx. 100 p. 35 illus., 25 in color. Softcover7 $49.99ISBN 978-3-319-02758-6

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D. Ribatti, University of Bari Medical School, Bari, Italy

Angiogenesis and Anti-Angiogenesis in Hematological MalignanciesIt has been generally accepted that angiogenesis is involved in the pathogenesis of hematological malignancies, like acute and chronic leukemia, lymphoma, myelodysplastic syndromes, myelo-proliferative neoplasms and multiple myeloma. The extent of angiogenesis in the bone marrow has been correlated with disease burden, prognosis and treatment outcome. Reciprocal positive and negative interactions between tumor cells and bone marrow stromal cells, namely hematopoietic stem cells, fibroblasts, osteoblasts/osteoclasts, en-dothelial cells, endothelial progenitor cells, T cells, macrophages and mast cells, mediated by an array of cytokines, receptors and adhesion molecules, modulate the angiogenic response in hematologi-cal tumors.

Features 7 Describes the critical role Angiogenesis plays in tumor progression and metastasis 7 In-formation on Anti-angiogenesis, one of most promising approaches to the treatment of cancer and metastasis 7 Deals with several anti-angiogenic molecules currently used alone or in combination in the treatment of haematological malignancies

Contents Preface.- Introduction.- Angiogenesis in multiple myeloma.- Angiogenesis in lymphomas.- Angio-genesis in leukemia.- Antiangiogenesis.- Conclud-ing remarks.- References.

Fields of interestCancer Research; Oncology; Hematology



Due January 2014

2014. Approx. 80 p. 44 illus., 30 in color. Hardcover7 $139.00ISBN 978-94-017-8034-6

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22

J. Rorbach, Medical Research Council, Cambridge, UK; A. J. Bobrowicz, Newcastle University The Medical School, Newcastle upon Tyne, UK (Eds)

PolyadenylationMethods and Protocols

Contents 3’ end Formation and Regulation of Eukaryotic mRNAs.- Poly(A) Polymerase-based Poly(A) Length assay.- Using Klenow Mediated Exten-sion to Measure Poly(A)-tail Length and Position in the Transcriptome.- Detection of Uridylated mRNAs.- Cytoplasmic Polyadenylation Assays.- In vitro Analysis of Transcriptional Activators and Polyadenylation.- Fluorescence Detection of Polyadenylation Reaction through the Coordina-tion of Adensoine2-coralyne-adensoine2.- Small molecule recognition of poly(A).-The Stem-loop Luciferase assay for Polyadenylation (SLAP) Method for Determining CstF-64-dependent Polyadenylation Activity.- Accurate Mapping of Cleavage and Polyadenylation Sites by 3’ Region Extraction and Deep Sequencing.- Polyadenyl-ation Site Prediction using PolyA-iEP Method.- Detecting alternative polyadenylation from Microarray Data.- Quantitative Polyadenylation Site Mapping with Single-molecule Direct RNA Sequencing.- RHAPA: A New Method to Quantify Alternative Polyadenylation.- Multiplex Analysis of PolyA-linked Sequences (MAPS): An RNA-seq Strategy to Profile poly(A+) RNA.- Global and Quantitative Profiling of Polyadenylated RNAs using PAS-seq.- High-throughput Sequencing of RNA Isolated by Crosslinking and Immunoprecip-itation (HITS-CLIP) to Determine Sites of Bind-ing of CstF-64 on Nascent RNAs.- Polyadenylation in Bacteria and Organelles.- In vivo Analysis of Polyadenylation in Prokaryotes.- Polyadenylation of RNA in E. coli: RNA Polymerase-associated (rA)n-synthetic Activities. [...]

Fields of interestHuman Genetics; Gene Function



Due February 2014

2014. 350 p. 68 illus., 18 in color. (Methods in Molecular Biology, Volume 1125) Hardcover7 $139.00ISBN 978-1-62703-970-3

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E. Schirmer, J. de las Heras, University of Edinburgh Wellcome Trust Centre for Cell Biology, Edinburgh, UK (Eds)

Cancer Biology and the Nuclear EnvelopeRecent Advances May Elucidate Past Paradoxes

Contents Section I: History and use of the nuclear envelope in cancer prognosis: Overview and perspective.- Cancer and the nuclear envelope, a history and perspective.- The role of the nuclear lamina in cancer and apoptosis.- The diagnostic pathology of the nuclear envelope in human cancers.- Nuclear morphometry, epigenetic changes, and clinical relevance in prostate cancer.- “To be or not to be in good shape”: diagnostic and clinical value of nuclear shape irregularities in thyroid and breast cancer.- Section II: The nuclear envelope in cell cycle regulation and signaling.- pRb and lamins in cell cycle regulation and aging.- Lamina-associat-ed polypeptide (LAP)2a and other LEM proteins in cancer biology.- NETs and cell cycle regula-tion.- Nuclear envelope regulation of signaling cascades.- Section III: Nuclear envelope regulation of the genome.- Nuclear envelope - connecting structural genome organization to regulation of gene expression.- Studying lamins in invertebrate models.- Lamin organization of chromosome positioning.- Section IV: Functions of the NPC in cancer.- NPC proteins linked in cancer over-view.- Roles of the nucleoporin Tpr in cancer and aging.- Ran GTPase in nuclear envelope formation and cancer metastasis.- Wnt signaling proteins associate with the nuclear pore complex: implica-tions for cancer.- Section V: The nuclear envelope in DNA damage and stress responses.- DNA dam-age and lamins. [...]

Fields of interestCancer Research; Medical Microbiology; Protein Science



Due February 2014

2014. X, 730 p. 97 illus., 83 in color. (Advances in Experimental Medicine and Biology, Volume 773) Hardcover7 $279.00ISBN 978-1-4899-8031-1

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S. R. Singh, National Cancer Institute Mouse Cancer Genetics Program, Frederick, MD, USA; P. Rameshwar, UMDNJ-NJ Medical School, Newark, NJ, USA (Eds)

MicroRNA in Development and in the Progression of CancermiRNAs are a class of endogenous, small non-protein coding RNA molecules (~ 22 nucleotides) which are novel post-transcriptional regulators of gene expression. Since we have hundreds of miRNAs, the major challenge is now to under-stand their specific biological function. In fact the experimental evidence suggests that signaling pathways could be ideal candidates for miRNA-mediated regulation. Several studies suggest that miRNAs affect the responsiveness of cells to sig-naling molecules such as WNT, Notch, TGF-β and EGFR. Altered expression of particular miRNAs has been implicated in the onset and development of cancer and could be used as potential biomark-ers for the disease. Recently, many studies have found miRNAs have crucial regulatory roles in Cancer stem cells (CSCs) a kind of tumor initiat-ing cells (TICs) and dormancy. Findings also suggest that DNA methylation may be important in regulating the expression of many miRNAs in several cancer initiating cells. Several miRNAs are known to either upregulated or downregulated in CSCs when compared to non-cancerous cells from the same tissues.

Features 7 Provides a more complete understanding of miRNAs function 7 Explore how miRNAs regulate normal development, diseases including cancers and stem cells fate 7 Presents the great potential of miRNAs in CSCs and potential thera-peutic advances for cancer

Fields of interestCancer Research; Gene Expression; Medical Microbiology



Due April 2014

2014. X, 270 p. 30 illus. in color. Hardcover7 approx. $189.00ISBN 978-1-4899-8064-9

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23

G. Tosini, Morehouse School of Medicine, Atlanta, GA, USA; P. M. Iuvone, Emory Eye Center, Atlanta, GA, USA; D. G. McMahon, Vanderbilt University Medical Center, Nashville, TN, USA; S. P. Collin, The University of Western Australia, Crawley, WA, Australia (Eds)

The Retina and Circadian RhythmsDaily rhythms are a ubiquitous feature of living systems. Generally, these rhythms are not just passive consequences of cyclic fluctuations in the environment, but instead originate within the organism.

Features 7 Provides a comprehensive review of the retinal circadian rhythmicity and photorecep-tion 7 A unique publication for a special topic course in neurobiology for post-docs, upper level undergraduate or graduate courses 7 A useful tool for clinicians and healthcare providers about the daily changes in the retina and how these changes may influence treatment and outcome

Contents 1. Introduction.- 2. Fundamental Retinal Circuitry for Circadian Rhythms.- 3. Circadian photorecep-tion: from phototransduction to behaviour.- 4. Role of Melatonin and Dopamine in the Regula-tion of Retinal Circadian Rhythms.- 5. Circadian Organization of the Vertebrate Retina.- 6. Rhyth-micity of the Retinal Pigment Epithelium.- 7. Retinal Circadian Rhythms in Mammals Revealed Using Electroretinography.- 8. Circadian Clock and Light Induced Retinal Damage.- 9. Circadian Rhythms and Vision in Zebrafish.- 10. Circadian Modulation of the Limulus Eye for Day and Night Vision.- 11. Molluscan Ocular Pacemakers: Les-sons Learned.

Fields of interestNeurosciences; Ophthalmology; Neurobiology



Due January 2014

2014. XX, 330 p. 50 illus., 33 in color. (Springer Series in Vision Research, Volume 1) Hardcover7 $189.00ISBN 978-1-4614-9612-0

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B. Weber, F. Helmchen, University of Zurich, , Switzerland (Eds)

Optical Imaging of Neocortical DynamicsThe application of optical methods for investi-gating neocortical circuit dynamics has greatly expanded in recent years, providing novel insights into the fascinating world of brain function.

Features 7 Presents introductory material, methods to investigate changes in neuronal and glial activity, and optical imaging methods probing metabolic states 7 Features detailed techniques from the labs of experts 7 Includes key implementation advice

Contents Neocortex in the Spotlight: Concepts, Questions, and Methods.- Principles and Fundamentals of Optical Imaging.- Optical Properties of Neural Tissue.- Fluorescent Indicators for Functional Optical Imaging.- Optogenetic Tools for Control of Neural Activity.- In Vivo Dendritic Mapping of Sensory Inputs in Cortical Neurons.- In Vivo Pop-ulation Imaging of Dendritic Integration in Neo-cortex.- Voltage-Sensitive Dye Imaging of Cortical Dynamics.- Two-Photon Imaging of Neuronal Network Dynamics in Neocortex.- Chronic Two-Photon Imaging of Neural Activity in the Anesthe-tized and Awake Behaving Rodent.- Neocortical Circuit Interrogation with Optogenetics.- Imaging of Astrocytic Activity in Living Rodents.- Imaging Morphology and Function of Cortical Microglia.- Functional Imaging of Cerebral Oxygenation with Intrinsic Optical Contrast and Phosphorescent Probes.- Laser Speckle Imaging of Cerebral Blood Flow.- Two-Photon Microscopy to Measure Blood Flow and Concurrent Brain Cell Activity.

Fields of interestNeurosciences; Neurology



Due January 2014

2014. XX, 280 p. 67 illus., 64 in color. (Neuromethods, Volume 85) Hardcover7 $119.00ISBN 978-1-62703-784-6

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