Peak Scientific Instruments Ltd HOW DO I CHOOSE THE RIGHT GAS MANAGEMENT SYSTEM? What are the possible sources of gas? Who has experience about Gas Management.

Peak Scientific Instruments Ltd

HOW DO I CHOOSE THE RIGHT GAS MANAGEMENT SYSTEM?

•What are the possible sources of gas?

•Who has experience about Gas Management Systems and can advise me?

•What information do I need about LC/MS Gas requirements and where will I find it?

•What are the decisions I need to make?

•Which one will be best for my lab / my LCMS system(s)?

•Are there any other considerations I should think about?

•Who will install the gas management system?

•What if I have problems and it stops working?

•How much will it cost to run?


WHAT ARE THE POSSIBLE SOURCES OF GAS?

•In house gas already available

•Liquid Nitrogen Dewar

•Cylinder gas

•Industrial gas generator

•Laboratory gas generator.

WHO HAS EXPERIENCE ABOUT GAS MANAGEMENT SYSTEMS AND CAN ADVISE ME?

•Colleague with LC/MS experience

•Company preference already in place

•LC/MS user group

•Local guru or expert in country

•Personal knowledge/experience

•Technical publications

•Internet - Google

•LC/MS supplier

•Gas management system supplier.



END USER CHOICESEND USER CHOICES

IN HOUSE GASDEWARCYLINDERLABORATORY GAS GENERATORINDUSTRIAL GAS GENERATOR

LCMS MANUFACTURER

COLLEAGUECOMPANY PREFERENCELC/MS USER GROUPLOCAL GURU OR EXPERTPERSONAL KNOWLEDGE

ALTERNATIVES RECOMMENDATIONS

SUMMARY OF GAS SOURCES AND INFORMATION


WHAT INFORMATION DO I NEED ABOUT LC/MS GAS REQUIREMENTS AND WHERE WILL I FIND IT?

• Consult the LCMS manufacturer/gas supplier

• Confirm the gas requirements (nitrogen, air, other?)

• Confirm the required specifications for flow and pressure

• Are there any other special gas requirements?

• Consult the LCMS site prep guide if available

• Is there a defined level of noise acceptable in the laboratory

NOW YOU HAVE A GOOD IDEA OF WHAT YOU REQUIRE.

WHICH GAS MANAGEMENT SYSTEM WILL BE BEST FOR MY LAB AND MY LCMS SYSTEMS?

•In house gas

•Liquid Nitrogen Dewar

•Cylinder gas

•Industrial gas generator

•Laboratory gas generator

SO HOW DO I DECIDE WHICH ONE?



WHAT ARE THE DECISIONS I NEED TO MAKE?

“What is right for the application and your lab?”

• Stand alone gas generator for each LCMS in lab (using existing house air)?

• Stand alone gas generator with separate external air compressor?

• Laboratory gas generator with built in compressors for each LCMS ?

• How many LCMS systems will require gas?

• Is this likely to change (increase) in the near future?

• If more than one LCMS, will they all have the same gas requirements?

• Are they located in the same area/laboratory?

• What are the distances from generator to LCMS?

• Are there any special Health & Safety Regulations to be considered?

NOW YOU KNOW WHAT DECISIONS NEED TO BE MADE!


USING EXISTING HOUSE AIR SUPPLY

. CAUTION!• If you select a gas generator for use with an existing house air

supply, make sure the air is of good quality and has the capacity to supply the correct flow and pressure to the gas generator.

• You must also ensure that the air supply will not contaminate the generator or the LC/MS System – it must be

Clean, Dry and Oil – free

• The generator should only ever be connected to a clean, dry and oil-free source of compressed air. If in any doubt, do not use this source of air.

• A regulated minimum pressure of 120 psig is required for the generator to operate correctly.

NB. Contaminated air supplies are a common source of problems!


USING EXISTING OR NEW PIPEWORK?

.• Is the generator to be connected to existing or new pipework?

• If you plan to use existing pipework, has it been pressure/leak tested by a competent, qualified technician?

• Can you guarantee that it is clean and free of contaminants?

• What is the i.d/o.d of the tubing?

• Do you know which material the tubing is made from?

• If in any doubt, do not use this existing pipework – use new tubing of the correct internal diameter and material type.

NB. Contaminated pipework is a common source of problems!

CAUTION!


WHICH GAS MANAGEMENT SYSTEM WILL BE BEST FOR MY LAB AND MY LCMS SYSTEMS?

• In house gas x

• Liquid Nitrogen Dewar x

• Cylinder gas x

• Industrial gas generator √

• Laboratory gas generator √

So if I choose a generator, what are the options and how do I decide which is best for me?


SO HOW DO I DECIDE WHICH GENERATOR?

Let me show you five gas generator possibilities:

Single LC/MS gas generator

1. With internal (built-in) compressors2. With separate air compressor system3. With separate air system and possibility to upgrade

Multi LC/MS gas generator

4. With separate air system and individual nitrogen generators (one for each LCMS system)5. With separate air system and one high capacity nitrogen generator (enough to supply all systems running at full

flow simultaneously)


S upply L ine S ize

D istance "L"L ine S ize (O D)

0 - 10 m

1/4" (6m m )

10m - 30m

3/8" (10m m )

N otes :-U se supp lied tub ing to connect G enerator to LC /M Sw here possib le

M ax D istance (L)

S ing le System Set-upN x10D R G enerator

IO

N itroGenP eak S c ien tific

N x10D R N itrogen G enerator

30m - 50m

1/2" (12m m )

IG -013-01D oc N o

D raw n D ate

06-04-07S G M

System Insta lla tion G uide

NITROGEN GENERATOR

WITH INTERNAL COMPRESSORS

N2

SINGLE LCMS SYSTEM


N M 20ZG enerator

S upp ly L ine S ize


0 - 30 m

3/8" (10m m )

30m - 50m

1/2" (12m m )

N otes :-U se supplied tubing to connect G enerator to LC /M S

M ax D istance (L)

N M 30L System Set-upA x20D R C om pressor

IO

A irGenP eak S c ientific

A x20DR Com pressor

P E AKS C I E N T I F I C

P EA KS C I E N T I F I C

IG -017-01D oc N o

D raw n D a te

06-04-07S G M

S ystem Insta lla tion G uide

NITROGEN GENERATOR

SINGLE LCMS SYSTEM

AIR

N2

AIR COMPRESSOR


A i r C om pressor

0

5

10 15

20

25

A ir C om pressor(A tlas Copco SF1FF)

A ir Receiver(125 Ltr)

N M 30LG enerator

P ressureR egulator(8 Barg)

N RV

1/2" L ine

P E A KS C I E N T I F I C

Supply L ine S ize


0 - 30 m

3/8" (10m m )

30m - 50m

1/2" (12m m ) N otes :-

C om pressor should be 10 Barg M odel w ith D ryerR eceiver should be adjacent to Com pressorU se supplied tubing to connect G enerator to LC /M S

N M 30L System Set-upS ing le System

M ax D istance (L)

P E A KS C I E N T I F I C

IG -015-01D oc N o

D raw n D a te

06-04-07S G M


AIR

N2

SINGLE LCMS SYSTEM WITH POSSIBLITY OF FUTURE UPGRADE


A i r C o m pr essor

0

5

10 15

20

25

A ir C om pressor(A tlas C opco SFxFF)

A ir R ece iverS ee N ote

N M 30LG enerator

N RV

1/2" L ine


D istance "L"

L ine S ize (O D )

0 - 30 m

3/8"(10m m )

30m - 50m

1/2"(12m m )

N otes :-

C om pressor shou ld be 10 Barg M odel w ith D ryerR ece iver shou ld be adjacent to C om pressorU se supp lied tub ing to connect G enerator to LC /M S


D rop L ines at additiona lG enera tor Locations(3 /8" or 10m m )

N o o f G enerators 2 - 3 4 - 8 2 - 3 4 - 8

3 /4"(20m m )

1/2"(12m m )

C om pressor Selection

N o o f G enerators

C om pressor SF1 FF SF2 FF S F4 FF S F6 FF S F8 FF S F11 FF

1 2 3 4 - 5 6 - 7 8

A ir R ece iver (L trs) 127 127 250 500 700 1000

N M 30L System Set-upM ultip le System s

M ax D istance (L)

P EAKS C I E N T I F I C

PEAKS C I E N T I F I C

IG -018-01D oc N o

D raw n D ate

06-04-07S G M

S ystem Insta lla tion G uide

AIR

N2

MULTI LCMS SYSTEM WITH POSSIBLITY OF FUTURE UPGRADE


0

5

10 15

20

25

A ir C om pressor A ir R ece iver N M xxxLG enerator


N otes :-C om pressor shou ld be 10 Barg M odel w ith D ryer.G enera tor and R ece iver should be adjacent to C om pressor.G enera tor S e lection based on m axim um 30Litres/m in dem and.For instrum ents less than 30 l/m in apply form ual g = N x(d/30)w here g is Virtua l N o of Instrum ents, N is Actua l N um ber o f Instrum ents,d is actual G as D em and.

N M xxxL S ystem Set-upM ulip le LC /M S

N RV

Line size as perC om pressor O utle t

D rop L ines at additiona lInstrum ent Locations(1 /4" or 6m m )

M ax D istance (L)

O U T L E T

IN L E T

S election Table

N o o f Instrum ents

C om pressor SF4 FF SF6 FF S F8 FF S F11 FF S F15 FF

N M 60L N M 120L N M 180L N M 240L N M 300L

A ir R eceiver (Ltrs) 250 250 500 700 1000

P eak G enerator

1 - 2 3 - 4 5 - 6 7 - 8 9 - 10


D istance "L"

L ine S ize (O D )

0 - 30 m 30m - 50m

N o o f Instrum ents 4 - 6 7+ 4 - 6 7+

0

5

10 15

20

25

Loca l R egula tor(O ptiona l)

IG -020-01D oc N o

D raw n D ate

06-04-07S G M


1 - 3 1 - 3

3 /8"(10m m )

1/2"(12m m )

3/4"(20m m )

1/2"(12m m )

3/4"(20m m )

1"(25m m )

MULTI LCMS SYSTEMS WITH POSSIBLITY OF FUTURE UPGRADE


NM30L NM30LA N110DR

Can be wall mountedor floor standing

Floor standing Floor standing – fits under most standard lab benches

WHAT DO GAS GENERATORS LOOK LIKE?

THESE ARE ALL DESIGNED FOR SINGLE LC/MS SYSTEMS AND ARE INTENDED TO BELOCATED CLOSE TO THE INSTRUMENTS IN THE LAB


ARE THERE ANY OTHER CONSIDERATIONS?

• General Surrounding Environment

• Location – Free Air Space

• Temperature (5-25°C for internal compressors)

• Air Conditioning on 24/7?

• Relative Humidity – Max 70%

• Altitude – Max 2000 metres

• Electrical requirements – 230V ± 10% (50/60Hz)

• Local Health & Safety Regulations

• Noise <59dB (A) for internal compressors

• Maximum outlet pressure is 100psi


WHO WILL INSTALL THE GAS MANAGEMENT SYSTEM?

• This will vary from country to country

• Always make sure you know your responsibilities

• Refer to the site prep guides from the manufacturer(s)

• Check that there are no health & safety obstacles

• Inform FM people and anyone likely to be affected

• Fulfil those commitments prior to installation

• Agree what has to be done with the installation engineer

• Set clear expectations – no surprises

• Carry out an operational check with the engineer

• Ensure everything works prior to engineer departing


WHAT IF THE GENERATOR STOPS WORKING?

• You need to think ahead how you will maintain your system

• What is your anticipated usage?

• What is the required uptime?

• How many PMs will be required annually?

• Will you buy multiple years service up front?

• Is there a special budget required?

• Is a service plan good value for money versus a dewar?

• What is the return on investment over 5 years?

• Can I work on a time and materials basis?


WHAT IF THE GENERATOR STOPS WORKING?

• Peak Scientific service plans available to purchase along with generator or

retrospectively

• Peak Scientific takes full responsibility for all generator service

• All work carried out by Peak Scientific engineers

• Priority response for clinical customers or customers with Peak Scientific

complete service plan or warranty

• Normally within 48 hours or sooner depending on customer location

• Peak has >99% first time fix rate within 48 hours


Return on Investment Calculator

Enter Values

Cost of Replacement Cylinder € 15.00

Rental Charge € 20.00

Monthly Delivery Charge € 5.00

Cost of Monthly Labour to Change

Cylinders € 150.00

Hours Worked Per Day 9

Days Worked per Week 5

Number of Cylinders per Week 5

Number of Cylinders per Month 20

Running Costs Per Month € 855.00

Cost of NM30LA € 13,592.00

Return on Investment 16 Months

HOW MUCH WILL A GAS GENERATOR COST TO RUN?



THE DESIGN OF LC/MS SYSTEMS CONTINUES TO EVOLVE VERY RAPIDLY AND THEY ALL HAVE DIFFERENT GAS REQUIREMENTS

Scientists are continually looking for

•Better qualitative and quantitative performance

•More sensitivity

•Improved resolution

•Better productivity and efficiency

•New LCMS models are introduced every year

This often means Peak Scientific needs to produce a new generator to match the needs of the latest LCMS system


THE PEAK SCIENTIFIC APPROACH TO GAS GENERATORS FOR LC/MS

• Which LCMS manufacturer and model?

• Designs and specifications vary from model to model and so do the gas requirements!

• What is the type of instrument?

• Single or triple quad, TOF etc...?

• What is the application – ESi or APCi or both?

In summary –

The Peak Scientific approach is to design and manufacture bespoke generators which exactly match the gas requirements of the mass spectrometer application


• Bespoke gas generators for the analytical instrument industry

• Mainly supplying generators for LCMS & GC instruments

• So Peak is a niche market supplier to those OEMs

• Peak manufactures high purity nitrogen, hydrogen and zero air generators as well as some others for TOC, purge gas and calibration gas applications

• Our main focus is on supplying quality products backed up with worldwide service and support

• And of course, most important of all, as a specialist company in the gas generator market, we are proud of our reputation for first class CUSTOMER SATISFACTION ..................wherever you are

GAS GENERATORS – OUR ONLY BUSINESS

Peak Scientific Instruments Ltd HOW DO I CHOOSE THE RIGHT GAS MANAGEMENT SYSTEM? What are the possible sources of gas? Who has experience about Gas Management.

Documents

lcms gas requirements

gas management systems

gas requirements nitrogen

special gas requirements

possible sources of

right gas management

lcms systems

lcms manufacturergas