Paul Wiener Senior Vice President Advances in the Treatment of Scars and Striae* Non-Ablative Fractional Technology pending FDA Submission Palomar Medical Technologies 2008. All rights reserved.
Paul WienerSenior Vice President
Advances in the Treatment of Scars and Striae*
Non-Ablative Fractional Technology
*pending FDA Submission
© Palomar Medical Technologies 2008. All rights reserved.
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Lux1540™ Fractional
Non-Ablative Laser
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Fractional Photothermolysis (FP)
Pigmented lesion
Vascular lesion
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Lux1540™ Fractional Non-Ablative Laser
• Wavelength: 1540 nm• Spot Size: 10 and 15 mm• Max. Energy: 70 mJ/mb• Pulse Width: 10-15 ms
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Current FDA Approvals for Lux 1540
• Soft tissue coagulation
• Skin resurfacing
• Acne scars
• Surgical scars
• Melasma
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Specifications: Lux1540 Laser
Parameters
Spot size, mm 15 10
Pitch, mm 0.6 1
Energy per microbeam, mJ 10 or 15 5 - 70
Pulsewidth, ms 10 or 15 10 or 15
Microbeams density, cm-2 320 100
•
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Fractional Resurfacing Using Microbeams of Thermal Damage
• Lattices of optical micro beams generate lattices
of micro denaturated columns in the skin
• Minimizes wound volume in comparison to bulk
treatment (ablative resurfacing)
• Increases safety margin
• Maximizes wound surface to recruit wound healing mediators
• Faster healing process
• Treat scars, roughness,+ dyschromia
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Treatment Conditions
• Moderate Correction– Melasma– Photodamage– Superficial Roughness
• Deep Correction
– Acne Scars
– Surgical Scars
– Striae* * Pending FDA Submission
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Placement of Handpiece
• Size of Sapphire
• Active area
• Not treated area
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Tile Cascade
50%
10mm/100mB
overlap:
line = 5mm
row = 2mm
15mm/320mB
overlap:
line = 7.5mm
row = 3mm
20%
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Treatment Technique
1. Pass
2. Pass
3. Pass
4. Pass
5. Pass
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Benefits of Tile Cascade
• Uniform coverage• Optimal density• Total energy is delivered to an area before
significant edema occur– This ensures good, consistent depth of columns
from the first pass to the last
• Good patient comfort– Can post cool treated area with CoolRoller
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The Rotating Technique
• Keep the handpiece at the same place and rotate each pass from about 45o
• Aids with discomfort .
• Thanks to Dr. Maurice Adatto, Geneva Switzerland, for his work on this technique
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Scars
• 4.5 to 16% of the general population affected by scars.
• Impact of scars:– Aesthetic disfigurement and resulting impacts on
patient psyche.– Functional issues: poor elasticity of scar tissue
can limit movement in areas of the body that were extensively damaged
– Pruritis, pain dysthesia
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Etiology of Scars
• Scars are caused by abnormal cytokine (TGF-Beta) mediated wound repair mechanism. Scar tissue lacks the tensile strength, elasticity, and pliability of normal skin
• Types of Scars:– Hypertrophic scars are raised erythematous or
hypopigmented. – Atrophic scars are dermal depressions caused by
inflammatory destruction of dermal collagen (bites, varicella, acne, etc.) or mechanical loss of dermis and resultant thinned epidermis (surgical, traumatic, splayed scars).
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Treatment of Scars
• Current treatments for post-surgical and post-traumatic scars have issues of efficacy or significant side effects.
• Current treatments:
– PDL for hypertrophic scars and keloids gives inconsistent results. • Common side effects: Purpura for 7-10 days
– Recontouring of atrophic scars with CO2 and Er:YAG laser resurfacing (1-2 tx).
• Common side effects: Extended patient downtime, PIH, infection, possible hypertrophic scarring and hypopigmentation.
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Fractional Non-Ablative Treatment of Scars
• Fractional photothermolysis creates columns of thermal damage surrounded by healthy tissue
• Potential for efficacy with minimal patient down time and side effects
• Potential mechanisms to improve scars:
– Dermal collagen and elastin remodeling
– Photothermolysis of scar microvasculature in dermis
– Normalization of pigmentation via migration of normal melanocytes at boundaries of thermally coagulated columns.
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Scar Histology after Treatment with Lux1540™
Atrophic Scar (baseline) Atrophic Scar Tissue 2 weeks post tx with 1540
Coagulation Zone
Note improvement in collagen organization; more rete ridges
Vasily & Tannous, MD
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Scar Histology after Treatment with Lux1540™
Atrophic Scar Tissue (baseline) Atrophic Scar Tissue 2 weeks post tx with 1540
Note increased elastin; more organized elastin fibers
Silver StainVasily & Tannous, MD
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Deep Correction: Acne Scars
Improve thumbprint and ice pick scarring.• Treatment strategy: 10 mm, 15 ms, 50-70 mJ/mb, 3-5
passes.• Stretch skin, use compression = good contact.• If surface has irregular contour, use LuxLotion.• Blanching during Tx is common, resolves in
30 minutes.• May see short-term improvement, but full benefit
takes about 4-6 months.
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Post 3 Treatments
Pre-Treatment
Maurice Adatto, MDGeneva, Switzerland
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Lux1540 Fractional
2 months Post 4 Treatments2 months Post 4 TreatmentsPre TreatmentPre Treatment
Stan Kovac., MD
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Acne scar Lux1540
Photos courtesy of Robert and Margaret Weiss, MD
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Pre Tx 1 month post Tx #7 with 1540
Lux1540 Fractional ™
David B. Vasily, MD
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Deep Correction: Surgical & Traumatic Scars
• Similar approach to acne scars• Treatment strategy:10 mm, 15 ms, 50-60 mJ/mb,
3-5 passes• Improvement seen with single Tx at 3-4 weeks –
continued improvement over time, additional Tx
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DV#26 Pre-Treatment
2
Post 3 Treatments3-5 weeks apart
Post Skin Graft ScarAesthetica Cosmetic & Laser Center
David B. Vasily, M.D.
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Pre Tx6 Weeks Post 2 Treatments
Post Surgical ScarAesthetica Cosmetic & Laser Center
David B. Vasily, M.D.
Pre-Treatment
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Pre-Treatment 3 Months Post 3 Treatments
Aesthetica Cosmetic & Laser CenterDavid B. Vasily, M.D.
Scar Treatment of PostTattoo Removal Scar with Lux1540™
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Pre-Treatment
6 Weeks Post3 Treatments
Treatment of Surgical Scar with Lux1540™
Aesthetica Cosmetic & Laser CenterDavid B. Vasily, M.D.
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36223
1 Month Post TreatmentPre-Treatment
Maurice Adatto, MDGeneva, Switzerland
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6873
1 Month Post 3 TreatmentsPre-Treatment
Maurice Adatto, MDGeneva, Switzerland
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Mirror EnhanceDavid B. Vasily, MD
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Pre-treatment
3 wks. Post TX#4 with 1540
Treatment of 40-year old Bullous Dermatosis Scars with Lux1540™
David Vasily, MD
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Post 3 1540 TxPre-1540 Treatment
Remodeling of Scar Tissue with Lux1540
David Vasily, MD
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Striae
• Associated with stretching of the skin
• Glucocorticoid hormones prevent fibroblasts from forming collagen & elastin fibrils necessary to keep rapidly growing skin taunt
• Creates a lack of supportive material as the skin is stretched leading to epidermal and dermal tears
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Striae
• Striae may also occur as a result of abnormal collagen formation, or a result of medications or chemicals that interfere with collagen formation.
• May also be associated with longtime use of cortisone compounds, diabetes, Cushing disease, Ehlers-Danlos syndrome, post-pregnancy, and rapid weight gain or increased muscle girth.– 75-90% of women develop some degree of stretch marks
during pregnancy. The sustained hormone levels usually results in appearance during month 6-7
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Deep Correction: Striae
• Studies ongoing
• Good results reported
• Settings: 10 mm, 15 ms, 40-70 mJ/mb, 3-5 passes– Lower energy, higher density – Higher energy, lower density
• Increased risk of PIH and prolonged erythema
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Photos courtesy of Francesca de Angelis, MD
Striae Lux1540
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Photos courtesy of Francesca de Angelis, MD
Striae Lux1540
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Photos courtesy of Francesca de Angelis, MD
Striae Lux1540
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Photos courtesy of Dr. Kolesnikova Milan,Italy
Striae Lux1540
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Baseline Post-Treatment
Photos courtesy of Dr. Kolesnikova Milan,Italy
Striae Lux1540
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Baseline Post-Treatment
Photos courtesy of Dr. Kolesnikova Milan,Italy
Striae Lux1540
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Lux 1540
Striae
Baseline Post-Treatment
Photos courtesy of Dr. Kolesnikova Milan,Italy
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Treated sideDr. deAngelis
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Striae Lux 1540 + Lux DeepIR
Photos courtesy of and Maurice A. Adatto, MD
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Striae Lux 1540 + Lux DeepIR
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6 Months Post-Treatment
Pre-Treatment
Aesthetica Cosmetic & Laser CenterDavid B. Vasily, M.D.
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Conclusions
• Fractional Photothermolysis using the Lux1540™ can be an effective treatment for surgical and post-traumatic scars.
• Lux1540 can significantly improve a variety of both hypertrophic and atrophic scars, despite the cause or age of scar, with minimal to no side effects
• Lux1540™ can be used to treat hypopigmented and hyperpigmented scars
• Lux1540™ is proving to be the most consistent light based modality of treatment for striae
• Lux1540™ treatments offer excellent convenience of use and patient comfort.
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StarLux Handpieces & Applications
Permanent Hair Reduction
PhotofacialsPigmented LesionsVascular Lesions
Acne PreventionPigmented Lesions
Leg VeinsVascular Lesions
Fractional Non-Ablative Skin Resurfacing and Soft Tissue Coagulation
Permanent Hair ReductionPigmented Lesions
Fractional Skin Tightening through Soft Tissue Coagulation
Fractional Ablative Skin Resurfacing