Nano Biomaterials

Alpesh Maru,5th Semester, Biomedical Department.October 5th , 2016Smaller World of Large Surface AreaNano Biomaterials

Nanomaterials

Classification of Nanomaterials

(a) 0D spheres and clusters,(b) 1D nanofibers, wires, and rods,(c) 2D films, plates, and networks,(d) 3D nanomaterials.

NanomaterialsApplications in Biology and Medicine.

Tissue regeneration and tissue engineering Development of tissues and organs is typically driven by the the action of multiple growth factors.Role of vascular growth factors in vessel formation. Stage A: Vasculogenesis Stage B: Angiogenic remodelling Stage C: Stabilization and maturation Stage D: Destabilization Stage E: Regression Stage F: Sprouting

Tissue regeneration and tissue engineering Polymer scaffold fabrication for growth factor release. Growth factors incorporated into polymer scaffolds by either (1) mixing with polymer particles before processing into scaffolds,(2) pre-encapsulating the factors into polymer microspheres that are then used to form scaffolds.

Degradable solid polymers In vivo applications

Classes of materials used in vivo Biodegradable: Breaks down by hydrolysis or enzymatic cleavage to form metabolized products Bioeliminable: Do not degrade; water-soluble, excretable Permanent or retrievable materials: Not degradable or excretable; requires surgery for removal

Estimated values of e and Lcritical for selected degradable polymers

Targeted Drug Delivery System

NanochipSmart monitoring & Drug Delivery System.

Nano BiomaterialsFurther Study & References.

References

Introduction to Nanomaterials by A. Alagarasi.

Nanomaterials, Application in medicine & biology by Kim A. Woodrow by University of Washington.

Fundamental of Nanomaterial, MTX9100(M.I.T. Lecture series).