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Medical Immunology DEPARTMENT OF IMMUNOLOGY 1 Immune system itself Neuro-endocrine system Components of Immune Regulation
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Medical ImmunologyDEPARTMENT OF IMMUNOLOGY 1 Immune system itself Neuro-endocrine system Components of Immune Regulation.

Dec 14, 2015

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Page 1: Medical ImmunologyDEPARTMENT OF IMMUNOLOGY 1  Immune system itself  Neuro-endocrine system Components of Immune Regulation.

Medical Immunology DEPARTMENT OF IMMUNOLOGY 1

Immune system itself

Neuro-endocrine system

Components of Immune Regulation

Page 2: Medical ImmunologyDEPARTMENT OF IMMUNOLOGY 1  Immune system itself  Neuro-endocrine system Components of Immune Regulation.

Medical Immunology DEPARTMENT OF IMMUNOLOGY 2

Positive events:

Enhancement of immune

response.

Negative events:

Suppression of immune response.

Effects of Immune Regulation

Page 3: Medical ImmunologyDEPARTMENT OF IMMUNOLOGY 1  Immune system itself  Neuro-endocrine system Components of Immune Regulation.

Medical Immunology DEPARTMENT OF IMMUNOLOGY 3

AgAg APCs

Th1 Tc

B Ab

PMNPMN

NK

Th2

ComplementComplement

Positive events: Enhancement of immune response.

TargetTargetcellscells

MHCMHCCKCK

MHCMHCCKCK

CKsCKs

CKsCKs

Page 4: Medical ImmunologyDEPARTMENT OF IMMUNOLOGY 1  Immune system itself  Neuro-endocrine system Components of Immune Regulation.

Medical Immunology DEPARTMENT OF IMMUNOLOGY 4

AgAg APC

Th1 Tc

B Ab

PMNPMN

NK

Th2

ComplementComplement

Negative events: Suppression of immune response.

TargetTargetcellscells

MHCMHCCKCK

MHCMHCCKCK

CKsCKs

CKsCKs

Ts

Page 5: Medical ImmunologyDEPARTMENT OF IMMUNOLOGY 1  Immune system itself  Neuro-endocrine system Components of Immune Regulation.

Medical Immunology DEPARTMENT OF IMMUNOLOGY 5

AgAg APCs

Th1 Tc

B Ab

PMNPMN

NK

Th2

ComplementComplement

Immune Response(IR)

TargetTargetcellscells

MHCMHCCKCK

MHCMHCCKCK

CKsCKs

CKsCKs

Page 6: Medical ImmunologyDEPARTMENT OF IMMUNOLOGY 1  Immune system itself  Neuro-endocrine system Components of Immune Regulation.

Medical Immunology DEPARTMENT OF IMMUNOLOGY 6

Ag concentration

Page 7: Medical ImmunologyDEPARTMENT OF IMMUNOLOGY 1  Immune system itself  Neuro-endocrine system Components of Immune Regulation.

Medical Immunology DEPARTMENT OF IMMUNOLOGY 7

AgAg APC

Th1 Tc

B Ab

PMNPMN

NK

Th2

ComplementComplement

Antigen Presentation

TargetTargetcellscells

MHCMHCCKCK

MHCMHCCKCK

CKsCKs

CKsCKs

Page 8: Medical ImmunologyDEPARTMENT OF IMMUNOLOGY 1  Immune system itself  Neuro-endocrine system Components of Immune Regulation.

Medical Immunology DEPARTMENT OF IMMUNOLOGY 8

MHC-Ag peptide complex formation ??

Page 9: Medical ImmunologyDEPARTMENT OF IMMUNOLOGY 1  Immune system itself  Neuro-endocrine system Components of Immune Regulation.

Medical Immunology DEPARTMENT OF IMMUNOLOGY 9

AgAg APC

Th1 Tc

B Ab

PMNPMN

NK

Th2

ComplementComplement

Immune Response(IR)

TargetTargetcellscells

MHCMHCCKCK

MHCMHCCKCK

CKsCKs

CKsCKs

Page 10: Medical ImmunologyDEPARTMENT OF IMMUNOLOGY 1  Immune system itself  Neuro-endocrine system Components of Immune Regulation.

Medical Immunology DEPARTMENT OF IMMUNOLOGY 10

APC

Th2Th1

+ +

IFNr

IL-4/10

Th1 and Th2 balance

Page 11: Medical ImmunologyDEPARTMENT OF IMMUNOLOGY 1  Immune system itself  Neuro-endocrine system Components of Immune Regulation.

Medical Immunology DEPARTMENT OF IMMUNOLOGY 11M e d i c a l I m m u n o l o g y 吉 林 大 学 基 础 医 学 院 免 疫 学 教 研 室 7

A n t a g o n i s mA n t a g o n i s m

IL-4

IFN activated Th cellB cell

blocks class switch to IgE induced by IL-4

Target cell Effect

Page 12: Medical ImmunologyDEPARTMENT OF IMMUNOLOGY 1  Immune system itself  Neuro-endocrine system Components of Immune Regulation.

Medical Immunology DEPARTMENT OF IMMUNOLOGY 12

AgAg APC

Th1 Tc

B Ab

PMNPMN

NK

Th2

ComplementComplement

Immune Response(IR)

TargetTargetcellscells

MHCMHCCKCK

MHCMHCCKCK

CKsCKs

CKsCKs

Ts

Page 13: Medical ImmunologyDEPARTMENT OF IMMUNOLOGY 1  Immune system itself  Neuro-endocrine system Components of Immune Regulation.

Medical Immunology DEPARTMENT OF IMMUNOLOGY 13

-- CD4+CD25+ Regulatory T cells

Self-reactiveT cellCD4+CD25+

Treg cells

Page 14: Medical ImmunologyDEPARTMENT OF IMMUNOLOGY 1  Immune system itself  Neuro-endocrine system Components of Immune Regulation.

Medical Immunology DEPARTMENT OF IMMUNOLOGY 14

Page 15: Medical ImmunologyDEPARTMENT OF IMMUNOLOGY 1  Immune system itself  Neuro-endocrine system Components of Immune Regulation.

Medical Immunology DEPARTMENT OF IMMUNOLOGY 15

Suppressive function :

Produce cytokines: IL-10/TGFβ

T-T interaction

Functions of CD4+CD25+ Treg cells

TregTregCD4+CD25+CD4+CD25+

TTCD4+CD25-CD4+CD25-

APCAPC

Page 16: Medical ImmunologyDEPARTMENT OF IMMUNOLOGY 1  Immune system itself  Neuro-endocrine system Components of Immune Regulation.

Medical Immunology DEPARTMENT OF IMMUNOLOGY 16

Functions of CD4+CD25+ Treg cells

Suppressive function :

Produce cytokines:

IL-10/TGFβ

Cell-cell contact

Page 17: Medical ImmunologyDEPARTMENT OF IMMUNOLOGY 1  Immune system itself  Neuro-endocrine system Components of Immune Regulation.

Medical Immunology DEPARTMENT OF IMMUNOLOGY 17

AgAg APC

Th1 Tc

B Ab

PMNPMN

NK

Th2

ComplementComplement

Immune Response(IR)

TargetTargetcellscells

MHCMHCCKCK

MHCMHCCKCK

CKsCKs

CKsCKs

Ts

Page 18: Medical ImmunologyDEPARTMENT OF IMMUNOLOGY 1  Immune system itself  Neuro-endocrine system Components of Immune Regulation.

Medical Immunology DEPARTMENT OF IMMUNOLOGY 18

Antibody Production by B cell

Th2

Page 19: Medical ImmunologyDEPARTMENT OF IMMUNOLOGY 1  Immune system itself  Neuro-endocrine system Components of Immune Regulation.

Medical Immunology DEPARTMENT OF IMMUNOLOGY 19

Ag+

Ab

Antibody responseAntibody response (Humoral immune response)(Humoral immune response)

Page 20: Medical ImmunologyDEPARTMENT OF IMMUNOLOGY 1  Immune system itself  Neuro-endocrine system Components of Immune Regulation.

Medical Immunology DEPARTMENT OF IMMUNOLOGY 20

Ag + Ab mediated B cell

图 12-1 抗原 - 抗体( IgG )复合物交联 BCR 和 FcR -BⅡ 对 B 细胞抑制作用示意

B cell

Page 21: Medical ImmunologyDEPARTMENT OF IMMUNOLOGY 1  Immune system itself  Neuro-endocrine system Components of Immune Regulation.

Medical Immunology DEPARTMENT OF IMMUNOLOGY 21

AgAg APC

Th1 Tc

B Ab

PMNPMN

NK

Th2

ComplementComplement

Immune Response(IR)

TargetTargetcellscells

MHCMHCCKCK

MHCMHCCKCK

CKsCKs

CKsCKs

Ts

Page 22: Medical ImmunologyDEPARTMENT OF IMMUNOLOGY 1  Immune system itself  Neuro-endocrine system Components of Immune Regulation.

Medical Immunology DEPARTMENT OF IMMUNOLOGY 22

— Inactivated itself

— Regulated by inhibitor

Regulation of complement

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Medical Immunology DEPARTMENT OF IMMUNOLOGY 23

Page 24: Medical ImmunologyDEPARTMENT OF IMMUNOLOGY 1  Immune system itself  Neuro-endocrine system Components of Immune Regulation.

Medical Immunology DEPARTMENT OF IMMUNOLOGY 24

Immune system itself

Neuro-endocrine system

Components of Immune Regulation

Page 25: Medical ImmunologyDEPARTMENT OF IMMUNOLOGY 1  Immune system itself  Neuro-endocrine system Components of Immune Regulation.

Medical Immunology DEPARTMENT OF IMMUNOLOGY 25

Regulations by neuro-endocrine system

Page 26: Medical ImmunologyDEPARTMENT OF IMMUNOLOGY 1  Immune system itself  Neuro-endocrine system Components of Immune Regulation.

Medical Immunology DEPARTMENT OF IMMUNOLOGY 26

Regulations by neuro-endocrine system

Page 27: Medical ImmunologyDEPARTMENT OF IMMUNOLOGY 1  Immune system itself  Neuro-endocrine system Components of Immune Regulation.

Medical Immunology DEPARTMENT OF IMMUNOLOGY 27

AgAg APC

Th1 Tc

B Ab

PMNPMN

NK

Th2

ComplementComplement

TargetTargetcellscells

MHCMHCCKCK

MHCMHCCKCK

CKsCKs

CKsCKs

Ts

Regulation of immune response