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Lipids ก - Ministry of Public Health · Structural components ˘ biological membranes Energy reserves (triacylglycerols) Vitamins & hormones (Lipids & lipid derivatives) Lipid solubilization

May 06, 2018

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Page 1: Lipids ก - Ministry of Public Health · Structural components ˘ biological membranes Energy reserves (triacylglycerols) Vitamins & hormones (Lipids & lipid derivatives) Lipid solubilization

Lipids ก�� �����ก�

�� ������������ก...

ก���������� ���

�������������ก

28 ก�ก���� 52

Page 2: Lipids ก - Ministry of Public Health · Structural components ˘ biological membranes Energy reserves (triacylglycerols) Vitamins & hormones (Lipids & lipid derivatives) Lipid solubilization

���� (Lipids)

� �!�"������ �ก#� �$ก%��� &�'#��(�%� )*� �� +�$%%ก,� �� +�$%����&�'#%-.�%�ก�-%)��' �� +�$/%"/%�"

� )�0�$�� 1��23�

� �$�� 1�"�%��4� (4�.)�0��5�2� �0� %� 4%( ��%�/%(�

Page 3: Lipids ก - Ministry of Public Health · Structural components ˘ biological membranes Energy reserves (triacylglycerols) Vitamins & hormones (Lipids & lipid derivatives) Lipid solubilization

��������� Structural components ��� biological membranes� Energy reserves (triacylglycerols)� Vitamins & hormones (Lipids & lipid derivatives)� Lipid solubilization (Lipophilic bile acids)

'(�)*+�',- / ����������/�(0�1

Page 4: Lipids ก - Ministry of Public Health · Structural components ˘ biological membranes Energy reserves (triacylglycerols) Vitamins & hormones (Lipids & lipid derivatives) Lipid solubilization

����������� �������������

1. �������������(simple lipid) ���ก����ก���� ��������ก����� ����ก� �� �� (fat) ���� ��(oil) ����� (wax)

1. �� �� ��������������� �!�"�#$%&' (%��� 2. ���� ����������%�!�"�#$%&' (%��� 3. ���������!�"���ก����ก���� ��) ��ก#�*%+�ก�����ก�����

�ก� ���������,�-� .(%��� *�� ����.�� ����/�(�

Page 5: Lipids ก - Ministry of Public Health · Structural components ˘ biological membranes Energy reserves (triacylglycerols) Vitamins & hormones (Lipids & lipid derivatives) Lipid solubilization

����������� �������������

2.���������� �� ���� ������������ก�� (compound lipid) �����(,(�!�" �����0"����� ��1����ก���� ����ก� 2��)2�(,(� (phospholipid) �ก�)1�(,(� (glycolipid) ��� �(),)��-�� (lipoprotein)

Page 6: Lipids ก - Ministry of Public Health · Structural components ˘ biological membranes Energy reserves (triacylglycerols) Vitamins & hormones (Lipids & lipid derivatives) Lipid solubilization

����������� �������������

3.������������� (derived lipid) ����������ก���(�!���!�" �)1��������-ก-���3�ก�(,(�!�"�� �-���0"��3�ก �� ��-(1����(,(��/�� �������*�-�!�������(�!��� 34��'ก3����*�ก�#� �(,(� -�������#,��5��(,(�!�"���1�+ �/��

• glycerol• fatty acids• lipid soluble vitamins: A,D,E,K• steroid hormones • cholesterol, cholesterol ester • eicosanoids

Page 7: Lipids ก - Ministry of Public Health · Structural components ˘ biological membranes Energy reserves (triacylglycerols) Vitamins & hormones (Lipids & lipid derivatives) Lipid solubilization

http://www.biomanufacturing.org/gbc2/SOPs/Macromolecules.ppt#260,32,Lipids

Simple lipids: Triglyceride

Page 8: Lipids ก - Ministry of Public Health · Structural components ˘ biological membranes Energy reserves (triacylglycerols) Vitamins & hormones (Lipids & lipid derivatives) Lipid solubilization

CH2 O C

O

CH

CH2

R

OH

OH CH2 O CO

CH O CO

CH2 OH

R

R

CH2 O CO

CH O CO

CH2 O

R

R

C RO

Triglyceride

diglyceride

monoglyceride

Page 9: Lipids ก - Ministry of Public Health · Structural components ˘ biological membranes Energy reserves (triacylglycerols) Vitamins & hormones (Lipids & lipid derivatives) Lipid solubilization

� ก345�),�678���ก9:;� 2 ก=>8) 54�6ก8

Saturated fatty acid (ก345�),�/�@4�@�)A,(, 1,�CD94��E()

Unsaturated fatty acid (ก345�),�/�@45)8�@�)A,(, 1,�CD'G8)

� 5�),��@�)A,( 9/8� �� ��� �� ก�� ������� �� saturated fatty acid ���� !"#���ก $ ��%&ก'(�����) !*)+!��, -(./0� .� !

� 5�),�5)8�@�)A,( 9/8� �12��&�)���3�4 �12��&�5&,��.%6 ! �12��&�4 ก"2�7 � �� unsaturated fatty acid ���� !"#���ก $ ��%&ก'(�����) !�.%���, -(./0� .� !

ก�������

Page 10: Lipids ก - Ministry of Public Health · Structural components ˘ biological membranes Energy reserves (triacylglycerols) Vitamins & hormones (Lipids & lipid derivatives) Lipid solubilization

'��% 0�85%8 saturated fatty acid

"0����ก���3������(�%� �!� �5�A0

� lauric acid (C12) CH3(CH2)10COOH

� palmitic acid (C16) CH3(CH2)14COOH

� stearic acid (C18) CH3(CH2)16COOH,� �ก!�"�#�

�� ��3�ก��-� �ก���� ���(" -� �กก��ก���� ��� ��(" -�

- ก�������������� �� ��!��� �"�#� ���$% &����������!'� ��$���#���� ���%���$()%�*�ก���%ก����ก���&�+��%ก%,"��-�%�� �� " $ ก ����� ���. $ � %ก / % �� ����(%��%ก&� ��� � � ��� �-���!� ����+������()%+� �������� ��+��! ��������

Page 11: Lipids ก - Ministry of Public Health · Structural components ˘ biological membranes Energy reserves (triacylglycerols) Vitamins & hormones (Lipids & lipid derivatives) Lipid solubilization

� ��� C - C '0%ก���� ���&$ �. � +�$�����&$�A0% 0�8��% 1 ���&$ �!� ก)5���)�0%�.�'�� (unsaturated fatty acid) �0�

� Oleic acid (C18) CH3(CH2) 7CH = CH(CH2) 7COOH� Linoleic acid (C18)

CH3(CH2)4CH = CHCH2CH = CH - (CH2)6CH2 COOH

ก���������$��� ��(����%ก(�!�� �� "ก$ ก��0�����ก (oleic acid) "��ก����0�����ก (linoleic acid)���%ก+��.)%������� %� �.)%����%��� �.)%���&%ก!� ��

- ก�������������$��� �� ��!��� �"�#� ��%ก &���������� )% ���#�����$% ���%�&�()%�*�ก���%ก����ก���&�+��%ก%,"��-�%�� ��

Page 12: Lipids ก - Ministry of Public Health · Structural components ˘ biological membranes Energy reserves (triacylglycerols) Vitamins & hormones (Lipids & lipid derivatives) Lipid solubilization

PUFAs ก���������$��� ����% )%"��$� (poly unsaturatedfatty acid) ��$�

KD/8(E=43D4,7'�9=*9A�3�=�>ก/�@4L�9=M�4 �,N�'�9=*9A�3�=���4� (HDL)6=D'�9=*9A�3�=���5)84� (LDL) 17)�กL��N+�),�Q,�(9�=M�� �N+�),����(R14 �N+�),�9)=S4���AD(,�

MUFA ก���������$��� �� )%"��$����� (mono unsaturatedfatty acid) -�� Oleic acid ���%ก+� �.)%�����ก�ก �.)%����)%� %� �.)%������#��% �.)%���/����!�

Oleic acid (18:1) CH3(CH2) 7CH = CH(CH2) 7COOHKD/8(E=43D4,7'�9=*9A�3�=5)84� (LDL)9�8��,N�

Linoleic acid (18:2) Linolenic acid (18:3)

Arachidonic acid (20:4)

Page 13: Lipids ก - Ministry of Public Health · Structural components ˘ biological membranes Energy reserves (triacylglycerols) Vitamins & hormones (Lipids & lipid derivatives) Lipid solubilization

5�%��$��8� �67�����89�8ก�:;<���;��� 9�=��� 9��>� � 9�;�=��ก���7�?� ก � ��ก����ก@ AB� Aก :

A?C�����>�� ��D���A?C����E F�89��9������<�E :�AGE�Dก���7�HIJ�J��B�: A��� ก����: �J��B�: I�K�H�JA?C��67������:@67� L AE��D�����J��H�ก����:���6�M�กกN;:J�7����M<��>�H��67����;?M�J�:����6�BO�;�����?�����I��:J�������J���>�B�:Aก �;?

� ก�:;<���� 9�=������HIP� �7�HIJ�D:����A��A=����H�A�K�:�>�<O6� M�J����67����EK��89�8?� ��Q;<���;��� 9�=���>� BD:8=����<�E<��A����กก���;<���� 9�=��กN=��M=�กN���ก �H�?� ��QE�AI��D I�ก;:J���?� ��Q��กAก �;? BD;��=����D;�ก��ก��ก ���I���89�8;<����>�

Page 14: Lipids ก - Ministry of Public Health · Structural components ˘ biological membranes Energy reserves (triacylglycerols) Vitamins & hormones (Lipids & lipid derivatives) Lipid solubilization

Saturated fat and fatty acid

Unsaturated fatand fatty acid

Single bond

Page 15: Lipids ก - Ministry of Public Health · Structural components ˘ biological membranes Energy reserves (triacylglycerols) Vitamins & hormones (Lipids & lipid derivatives) Lipid solubilization

Saturated fatty acid

Unsaturated fatty acidhttp://www.biomanufacturing.org/gbc2/SOPs/Macromolecules.ppt#260,32,Lipids

Cis-form

Page 16: Lipids ก - Ministry of Public Health · Structural components ˘ biological membranes Energy reserves (triacylglycerols) Vitamins & hormones (Lipids & lipid derivatives) Lipid solubilization

ก�����������

Cis-form

Trans-form

Page 17: Lipids ก - Ministry of Public Health · Structural components ˘ biological membranes Energy reserves (triacylglycerols) Vitamins & hormones (Lipids & lipid derivatives) Lipid solubilization

1. 93�Eก/M��*8(� hydrocarbon ก8�� A,4 WeX 6=DA8�4�(E Woic + acidX

9/8� Hexadecane 9:;� Hexadecanoic acid(Palmitic acid, C16:0)

2. ก�37�กA+�6��8���� double bond )� 2 =,ก_`D 4,���N

8 7 6 5 4 3 2 1 677 ∆∆∆∆ 93�Eก)�K�ก:=�E COOHCH3−-CH2-CH2-CH2-CH2-CH2-CH2-COOH

∆∆∆∆

1 2 3 4 5 6 7 8 677 ωωωω (R�9)ก��) �3M� n-ωωωω terminus 93�Eก)�K�ก:=�E CH3

�=,กก�393�Eก/M��ก345�),� (Nomenclature)

Page 18: Lipids ก - Ministry of Public Health · Structural components ˘ biological membranes Energy reserves (triacylglycerols) Vitamins & hormones (Lipids & lipid derivatives) Lipid solubilization

ω Carbonor n

1 18

118

Oleic acid Linoleic acid Linolenic acid(ωωωω-9) (ωωωω-6) (ωωωω-3)

∆∆∆∆ carbonα

ββββ

9

12

15

18:1, ∆∆∆∆9, ωωωω-9 (or n-9)(Oleic acid)

18:2, ∆∆∆∆9,12 ωωωω-6(Linoleic acid)

18:3, ∆∆∆∆9,12,15, ωωωω-3(Linolenic acid)

Essential FAs

(-COOH)

(-CH3)

ก� � ก'3�+Q�08���&$�A05%8 unsaturated FA

�D��

�D��

Page 19: Lipids ก - Ministry of Public Health · Structural components ˘ biological membranes Energy reserves (triacylglycerols) Vitamins & hormones (Lipids & lipid derivatives) Lipid solubilization

Common

13.

Page 20: Lipids ก - Ministry of Public Health · Structural components ˘ biological membranes Energy reserves (triacylglycerols) Vitamins & hormones (Lipids & lipid derivatives) Lipid solubilization

&)%"�ก�� ��6� 2 ����7( �� "ก$�ก345�),�5)8K+�9:;� (Non Essential fatty acids) 9:;�ก345�),����38��ก�E*�)�3Q*3���9��54� �/�� ก����-��(ก (stearic acid) ก��)����(ก (oleicacid) ก����� (-(ก (palmitic acid) ����-��

�ก345�),�K+�9:;� (Essential fatty acids) 38��ก�E*3���5)854�6A8)�'(�)*+�',-6=DK+�9:;�A8�ก�34+�3�/�(@A677:กA@���)�>_Ej

)� 2 /�@4:� 18:2, ∆∆∆∆9,12 (linoleic acid, ωωωω-6 fatty acid)� 18:3, ∆∆∆∆9,12,15 (linolenic acid, ωωωω-3 fatty acid)

Arachidonic acid (20:4 ∆∆∆∆5,8,11,14 ) 9:;�ก345�),�K+�9:;� 6=DA���*3���)�K�ก linoleic acid

"�$�����7(���ก������� %�-�%�&)%��6� $��$%�ก%

Page 21: Lipids ก - Ministry of Public Health · Structural components ˘ biological membranes Energy reserves (triacylglycerols) Vitamins & hormones (Lipids & lipid derivatives) Lipid solubilization

http://themedicalbiochemistrypage.org/lipids.html

Essential fatty acids

Linoleic acid

Essential fatty acid

(ωωωω-6)

18:2∆9,12

Linolenic acid

18:3∆9,12,15

Arachidonic acid

20:4∆5,8,11,14 Precursor for eicosanoidsynthesis

Essential fatty acid

(ωωωω-3)

Cis - form

Page 22: Lipids ก - Ministry of Public Health · Structural components ˘ biological membranes Energy reserves (triacylglycerols) Vitamins & hormones (Lipids & lipid derivatives) Lipid solubilization

� ก345�),�A��677�+�5:L/�*3���ก345�),�5)8�@�)A,(/�@4�M��:� Linoleic acid (18:2, ωωωω-6) *3��� Arachidonic acid (20:4, ωωωω-6)� Linolenic acid *3��� ecosapentaenoic (EPA) (20:5, ωωωω-3) 6=D decosahexaenoic (DHA) (22:6, ωωωω-3) 17)�กL� fish oil� ก34 EPA /8(E:l��ก,�ก�36�S�A,(����=�49=M�4� ก34 DHA /8(EL�4���'(�)K+� 6=D ก�3)��9�S�

Page 23: Lipids ก - Ministry of Public Health · Structural components ˘ biological membranes Energy reserves (triacylglycerols) Vitamins & hormones (Lipids & lipid derivatives) Lipid solubilization

����R EPA & DHA 1� �-2%����23��-)4 (%�23�Q��ก/�23�Q��ก5%8ก)5���4�28Q�)

����23��- EPA DHA?������ 1.77 5.48?��:�ก:J�� 0.68 5.56?��� � 2.66 7.19?���� : 3.39 7.43?��ก:AI�K�� 1.44 7.54?��I��;�� 2.01 7.77?��A�K6����� 2.59 9.32?��ก��� 2.54 13.55

Page 24: Lipids ก - Ministry of Public Health · Structural components ˘ biological membranes Energy reserves (triacylglycerols) Vitamins & hormones (Lipids & lipid derivatives) Lipid solubilization

Lipoproteins

� :3Dก�74�(E protein & lipids� ��*8� lipids (fats) 6=D cholesterol L�38��ก�E� /�@4��� lipoproteins 93�E�=+�4,7A�)���4 6=D'(�)���6�8�

� ���4L�-8 6=D '(�)���6�8�A�+� (fat > protein) � ���49=Sก 6=D'(�)���6�8�*G� (fat < protein)

Page 25: Lipids ก - Ministry of Public Health · Structural components ˘ biological membranes Energy reserves (triacylglycerols) Vitamins & hormones (Lipids & lipid derivatives) Lipid solubilization

Density(g/ml)

Class Diameter (nm)

% protein

% cholesterol

% phospholipid

% triacylglycerol

>1.063 HDL 5-15 33 30 29 8

1.019-1.063 LDL 18-28 25 50 21 4

1.006-1.019 IDL 25-50 18 29 22 31

0.95-1.006 VLDL 30-80 10 22 18 50

<0.95 Chylomicrons 100-1000 <2 8 7 84

Chylomicrons6 ��!$� TG &%ก intestine ���� liver, skeletal muscle "�� adipose tissueLDL = low density lipoprotein6 ��!$� (newly synthesised) TG &%ก liver ���� adipose tissueIDL = Intermediate density lipoprotein6 ��6� intermediate molecule ����$%� VLDL "�� LDL, �ก �&���$��+� bloodVLDL = very low density lipoprotein6 ��!$� cholesterol &%ก liver ���� cells (���$%�ก%, "bad cholesterol" lipoproteinHDL = high density lipoprotein6 �ก#� cholesterol &%ก���.���� $%�X "���)%ก����� %!'$ liver, "good cholesterol" lipoprotein

Page 26: Lipids ก - Ministry of Public Health · Structural components ˘ biological membranes Energy reserves (triacylglycerols) Vitamins & hormones (Lipids & lipid derivatives) Lipid solubilization

A B

C D1

2

3

45

6

7

8

910

11

1213

14 15

16

17

Steroids

)1�������%��ก 10�

!� ����� (���ก78: steroid) ���������!�" �)1��������:,�� )�!�")1�������1������3�������%� 4 ��/0"� -��ก�� 1� �-ก-������/�(���-�����3�.�������-� YZ�ก�������ก��� !�"-(��'�ก����%��%������ ���-������-ก-���ก���������/�(�!�"�� ���-�3,�*�,0/�����-� -������!��!���1�+�����-�����*�����/�(-���*%+�10� ก����������) �

Page 27: Lipids ก - Ministry of Public Health · Structural components ˘ biological membranes Energy reserves (triacylglycerols) Vitamins & hormones (Lipids & lipid derivatives) Lipid solubilization

Steroids

�� ��������������

-1�����!����

-����) ������)�1���-(1��� !��%���!�"��ก8� 1�1# � �#������������(�� ก)!���-�

-����) ��,;

-ก��������

Page 28: Lipids ก - Ministry of Public Health · Structural components ˘ biological membranes Energy reserves (triacylglycerols) Vitamins & hormones (Lipids & lipid derivatives) Lipid solubilization

• lipid soluble vitamins: A,D,E,K

Precursor and Derived lipids

(Retinol)

(Tocopherols)

(Phylloquinones)(Calciferol)

Page 29: Lipids ก - Ministry of Public Health · Structural components ˘ biological membranes Energy reserves (triacylglycerols) Vitamins & hormones (Lipids & lipid derivatives) Lipid solubilization

• steroid hormones• cholesterol, cholesterol ester, cholic acid

Page 30: Lipids ก - Ministry of Public Health · Structural components ˘ biological membranes Energy reserves (triacylglycerols) Vitamins & hormones (Lipids & lipid derivatives) Lipid solubilization

����) ��,;

�!�)!��!�)�� �%�� �!�" 1�1# ก���3�(+�-(�)-�������0�,��5#� � !���,�<��ก��-��� = ����,;/�

),��3��!�)�� !��%���!�"1�1# �0"��#.��� ��'ก*���%���!�" �ก��-���1��&�%�0� ����3����0��

ก��������

[�� &%ก-���!�(����(� ��"���ก#�!�!��� +�/���.)%�� ก���.)%��(�!)%-�\-�� ก��0-��- &�()%�� %(��$�$������+��)%�! ��#ก"�����$����%-���!�(����(��'$+��%�%��� ��ก� �

Page 31: Lipids ก - Ministry of Public Health · Structural components ˘ biological membranes Energy reserves (triacylglycerols) Vitamins & hormones (Lipids & lipid derivatives) Lipid solubilization

Eicosanoids� non-saponifiable lipids *3���K�ก arachidonic acid ���54�K�กก�3*=�E phospholipid ��� membrane� Eicosanoids :

1. prostaglandins (PG) /8(EL�ก�3�=,���N+�E8�E���ก3D91�D����3 /8(E=4��ก�3�,ก9*7

2. Thromboxanes *3���K�ก PG-G2 ��� platelets )�q�C@rก3DA>��L��9ก@4 platelets aggregation �+�L��R=�@A�E>45�=

3. Prostacyclins *3���)�K�ก PG-G2 K�ก artery wall )�q�C@rE,7E,N�5)8L��9ก@4 platelet aggregation

4. Leukotrienes �+�L�� smooth muscle �4A,( �`D���)���ก�361� Q��)�ก�3u=@A)�ก9ก@�5:KD�+�L�� smooth muscle ����=�4=)5:E,�:�4�4A,( ��K�+�L��9ก@4 asthmatic attacks 54�

Page 32: Lipids ก - Ministry of Public Health · Structural components ˘ biological membranes Energy reserves (triacylglycerols) Vitamins & hormones (Lipids & lipid derivatives) Lipid solubilization

ก�)���ก)5����3� �!�)�0 �� 8�% %��43�1Q� ก�%�ก��8'0%)���2

♦ ��V �I��� A��� ��A�K6��♦ V����� V �I���MIJ� �8� 6����♦ ��Dก���7����<��=�� M�D;=A�K9��♦ ;���8���W M�D��<�EB ==ก=97� ����B7�A�K9��♦ >� ��J�ก��=97�= :A�K6�;:J����♦ ก��A?C�I���H�V>J��� ก��ก��M�J�H�V>JIP �

Page 33: Lipids ก - Ministry of Public Health · Structural components ˘ biological membranes Energy reserves (triacylglycerols) Vitamins & hormones (Lipids & lipid derivatives) Lipid solubilization

ก�)���ก)5����3� �!�)�0 �� 8�% %��43�1Q� ก�%�ก��8'0%)���2

♦ ก����กF�MV�A?C�;?;:J�J�♦ ��D<J���กA��♦ ����ก���8ก��AB� PA= �=M�DA�8���>J�J�H����A:Nก♦ ��I��HBM�D�D��ก��;I�A�8��<���I =�8?XPI�♦ ����:���I =�>�

Page 34: Lipids ก - Ministry of Public Health · Structural components ˘ biological membranes Energy reserves (triacylglycerols) Vitamins & hormones (Lipids & lipid derivatives) Lipid solubilization

*3>:'(�)*+�',-��� Lipids1. Fuel: L��1=,����*G� 9 kcal/ก3,) 54�6ก8 ก345�),�2. Energy storage: 54�6ก85A3ก=�9v�534j 9:;�*8(�)�ก3. Structural lipids: 54�6ก8 w�*Rw=@:x4 5ก=R'=@:x4 6=D R'9=*9A�3�=4. Insulation: ก,�ก�3*G-9*�E'(�)3���K�ก9�MN�9EM��A8��z 54�6ก8 5A3ก=�9v�534j5. {�(�5wwl�L�9*��LE:3D*��91M��L��ก�3*8�*,--�`5wwl����9*��:3D*��9ก@454�3(493S(:3�|K�ก*@��37ก(� 54�6ก8 w�*Rw=@:x4 5ก=R'=@:x46. '(7'>)�7(�ก�3 metabolism �3M��+��������9:;� conenzyme 54�6ก8 Fat-soluble vitamins7. '(7'>) body}s homeostasis 54�6ก8 prostaglandin, steroid homones8. ��*8�*�3:3Dก�75�),�L�38��ก�E 54�6ก8 plasma lipoproteins

Page 35: Lipids ก - Ministry of Public Health · Structural components ˘ biological membranes Energy reserves (triacylglycerols) Vitamins & hormones (Lipids & lipid derivatives) Lipid solubilization
Page 36: Lipids ก - Ministry of Public Health · Structural components ˘ biological membranes Energy reserves (triacylglycerols) Vitamins & hormones (Lipids & lipid derivatives) Lipid solubilization
Page 37: Lipids ก - Ministry of Public Health · Structural components ˘ biological membranes Energy reserves (triacylglycerols) Vitamins & hormones (Lipids & lipid derivatives) Lipid solubilization

�23�����-�4#ก�����"0���$ก%�5%8)5���%�.�'��)5���)�0%�.�'��+���� �ก#� � � +�$)5���)�0%�.�'��+��Q�� �� �ก#�1�"�"0��4�.+'ก'0�8ก�� �8'��8+"8

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�23�����-�4#ก�����"0���$ก%�5%8)5���%�.�'��)5���)�0%�.�'��+���� �ก#� � � +�$)5���)�0%�.�'��+��Q�� �� �ก#�1�"�"0��4�.+'ก'0�8ก�� �8'��8+"8

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Page 39: Lipids ก - Ministry of Public Health · Structural components ˘ biological membranes Energy reserves (triacylglycerols) Vitamins & hormones (Lipids & lipid derivatives) Lipid solubilization
Page 40: Lipids ก - Ministry of Public Health · Structural components ˘ biological membranes Energy reserves (triacylglycerols) Vitamins & hormones (Lipids & lipid derivatives) Lipid solubilization
Page 41: Lipids ก - Ministry of Public Health · Structural components ˘ biological membranes Energy reserves (triacylglycerols) Vitamins & hormones (Lipids & lipid derivatives) Lipid solubilization

"�"0��5%8)5���4�. Q��$"�

� AEK9��:����A�89��=����=���L A��� ��I��HBM�DI��:A�K�: I�K� ���DA�N� ���Yก���������ก(WHO) ���Yก����I��M�DAกF=�MI���I?�D����= (FAO) M�D�������I��HBMI���I��Z�A�� ก�(The American Heart Association) ;:JM�D�7���:����<��ก�:;<����89����� �=������K�

� SFA : MUFA : PUFA = <10% : 10-15% : <10%<��E�������89;:J���=�����

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�[�ก�� �4�.43�1Q��23���� "-.%�"���� �67����ก�������J��

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� ?� ��Qก�:;<���� ��DAE 9�<O6� A��� ���E���Y ���E� A���Y ก�:;<��������Y M�D����DAI�����=���L

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'��8+"8�# ก����� (Smoke Point)

41.941.941.941.980.980.980.980.9 ****22.722.722.722.733.833.833.833.836.036.036.036.019.019.019.019.030.030.030.030.0

77.977.977.977.9 ****----

58.058.058.058.0สัดสวนโอสัดสวนโอสัดสวนโอสัดสวนโอเมกาเมกาเมกาเมกา 9999

485.6 *485.6 *485.6 *485.6 *252.0 *252.0 *252.0 *252.0 *น้าํมนัเมลด็ชาน้าํมนัเมลด็ชาน้าํมนัเมลด็ชาน้าํมนัเมลด็ชา********482.0 *482.0 *482.0 *482.0 *250.0 *250.0 *250.0 *250.0 *น้าํมนัราํขาวน้าํมนัราํขาวน้าํมนัราํขาวน้าํมนัราํขาว

450.0450.0450.0450.0232.0232.0232.0232.0น้าํมนัขาวโพดน้าํมนัขาวโพดน้าํมนัขาวโพดน้าํมนัขาวโพด

ชนดิของน้าํมนัชนดิของน้าํมนัชนดิของน้าํมนัชนดิของน้าํมนั จดุเกดิควนัจดุเกดิควนัจดุเกดิควนัจดุเกดิควนั ( ( ( (CCCC)))) จดุเกดิควนัจดุเกดิควนัจดุเกดิควนัจดุเกดิควนั ( ( ( (FFFF))))น้าํมนัคาโนลาน้าํมนัคาโนลาน้าํมนัคาโนลาน้าํมนัคาโนลา 204.4204.4204.4204.4 400.0400.0400.0400.0น้าํมนัเมลด็องุนน้าํมนัเมลด็องุนน้าํมนัเมลด็องุนน้าํมนัเมลด็องุน 204.4204.4204.4204.4 400.0400.0400.0400.0น้าํมนัมะกอกน้าํมนัมะกอกน้าํมนัมะกอกน้าํมนัมะกอก 210.0210.0210.0210.0 410.0410.0410.0410.0น้าํมนัปาลมน้าํมนัปาลมน้าํมนัปาลมน้าํมนัปาลม 216.0216.0216.0216.0 420.8420.8420.8420.8น้าํมนัเมลด็ฝายน้าํมนัเมลด็ฝายน้าํมนัเมลด็ฝายน้าํมนัเมลด็ฝาย******** 230.0230.0230.0230.0 446.0446.0446.0446.0น้าํมนัเมลด็ทานตะวนัน้าํมนัเมลด็ทานตะวนัน้าํมนัเมลด็ทานตะวนัน้าํมนัเมลด็ทานตะวนั 232.0232.0232.0232.0 450.0450.0450.0450.0

น้าํมนัถัว่เหลอืงน้าํมนัถัว่เหลอืงน้าํมนัถัว่เหลอืงน้าํมนัถัว่เหลอืง 232.0232.0232.0232.0 450.0450.0450.0450.0

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�[�ก�� �4�.43�1Q��23���� "-.%�"���

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�[�ก�� �4�.43�1Q��23���� "-.%�"���

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�[�ก�� �4�.43�1Q��23���� "-.%�"���

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ก)5��� �3���� C �3�������&$�A0 m.p.(°°°°C)

Palmitic 16 - 63.1

Stearic 18 - 69.6

Oleic 18 1 13.4

Linoleic 18 2 -5

Linolenic 18 3 -11

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Trans Fat

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Hydrogenation�ก� '��)*� ��

� unsaturated triglyceride 43��[�ก�� �ก�� H2 � ����Q$ �0� Ni �!�'�� 08�[�ก�� �

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CH2-O-C(CH2)7CH=CH(CH2)7CH3 CH2-O- C-C17-H35

CH2 ~ O CH2 ~ Osaturated triglyceride

HH22//NiNi

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Trans Fat� (@C�ก�39=M�กu=@A0,`�j ��ก17'+�(8� Hydroginate ,Partial

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