Lipid Metabolism- 1 Fatty Acid Oxidation

8/3/2019 Lipid Metabolism- 1 Fatty Acid Oxidation

1/21

G`ttx @bho `fo _~h`bxadaxbk~caJkt`ncahrj 0

Jcnhahy`thcf cg rtc~ko g`t `fo c}ho`thcf

cg g`ttx `bhor

G`hr`a Em`thn JO5 \mO

G`b{atx cg Jkohbhfk! [fhwk~rhtx cg Ic~o`f

_^H@BXADAXBK^CA

D

A

X

B

K

^

C

AG@__X @BHO

G@__X @BHO

G@__X @BHO

8/3/2019 Lipid Metabolism- 1 Fatty Acid Oxidation

2/21

BM2*BM>*BM>*BM>*BM>*BM>*BM>*BM>*BM>*BM>*BM>*BCCM

G`ttx `bho

_mk |e` cg b`~nc}xa d~c{| hf g`ttx bho ?&=

Rc! `t |mxrhcacdhb`a |M g`ttx `bho k}hrtr `r `fhcf

BM2*BM>*BM>*BM>*BM>*BM>*BM>*BM>*BM>*BM>*BM>*BCC*

C~

BM2 -BM>(f BCC*

_mk mxo~cb`~ncf bm`hf b`f nk r`t{~`tko c~ ht j`x bcft`hf cfk

c~ jc~k oc{nak ncfor

BM2*BM>*BM>*BM>*BM>*BM:BM*BM>*BM:BM*-BM>(4*BCC*

[fr`t{~`tko G`ttx @bho

0=9>8!0> c~ 0=9-8!0>(

Ahfcakhb @bho

7

8/3/2019 Lipid Metabolism- 1 Fatty Acid Oxidation

3/21

Rcjk g`ttx bhor cg |mxrhcacdhb a hj|c~t`fbk

_~h`bxadaxbk~ca -_@D( c~ G@_ hr tmk

j`ic~ kfk~dx ~krk~wk hf tmk ncox

Ht hr jc~k kgghbhkft tc rtc~k kfk~dx hf

tmk gc~j cg_@D

8/3/2019 Lipid Metabolism- 1 Fatty Acid Oxidation

4/21

Tmx G@_ fct B`~ncmxo~`tkr3

) Jc~k ~ko{bko9

8 eb`a |k~ d~`j bcj|`~ko htm

? eb`a |k~ d~`j cgb`~ncmxo~`tkr

) Mxo~c|mcnhb9

b`f nk rtc~ko htmc{t M>C

b`~ncmxo~`tkr `~k mxo~c|mhahb

0 d~`j b`~ncmo~`tkr9 > d~`jr M>C

Tmx G@_ fct B`~ncmxo~`tkr3 -Bcfthf{ko(

@wk~`dk `o{at m`r 0< Ed cg G`t

Mc j`fx b`ac~hkr3

8

Tm`t hr tmk j`rr cgb`~ncmxo~`tkr tm`t|~co{bkr 8

8>&; Ed

Mc j{bm `tk~ htm ht3

8/3/2019 Lipid Metabolism- 1 Fatty Acid Oxidation

5/21

G@__X @BHO `r G[KAR

_mk j`ic~ g{ka {rko nx thrr{kr n{t Da{bcrk hrtmk j`ic~ bh~b{a`thfd G{ka

G{ka tx|k @jc{ft {rko# @jc{ft hf

0> mc{~r -eb`a( Ga{hor -eb`a(

G@ ;?< 2

Da{bcrk >=< =C 2 G@ % daxbk~ca

8/3/2019 Lipid Metabolism- 1 Fatty Acid Oxidation

6/21

Mc~jcfkr tm`t `bthw`tk tmk

Mc~jcfk Rkfrhthwk Ah|`rk Da{b`dcf

K|hfk|m~hfk

Fc~k|hfk|m~hfk

@B_M

8/3/2019 Lipid Metabolism- 1 Fatty Acid Oxidation

7/21

G`tk cg Daxbk~ca

Daxbk~ca

Da{bcfkcdkfkrhr

D

a

x

b

c

a

h

r

hr

C}ho`thcf cg G`ttx @bhor

G`ttx @bhor `~k t~`fr|c~tko tc thrr{kr

nc{fo tc `an{jhf

Okd~`oko nx c}ho`thcf `t b`~ncf

gcaacko nx bak`w`dk cg tc b`~ncf {fhtr

C *BM>* *B*

8/3/2019 Lipid Metabolism- 1 Fatty Acid Oxidation

8/21

C}ho`thcf cg G`ttx @bhor -cwk~whk(BM2 -BM>(f*BM>*BM>* BCC

*

BM2 -BM>(f *BM>*BM>*BC vBc@

C

BM2 -BM>(f *B*BM>*BC vBc@

BM2 -BM>(f *BC vBc@ % BM2*BC vBc@

@bthw`thcf cg G`ttx @bhor

Ichfhfd G&@ htm Bckfyxjk @

^BCvRBc@ -_mhckrtk~ ncfo(

G@ % MRBc@ % @_\ G@vBc@ % @J\ % \\h

\\h % M>C > \h

G@ % MRBc@ % @_\ G@vBc@ % @J\ % > \h@J\ % @_\ @O\ % @O\

8/3/2019 Lipid Metabolism- 1 Fatty Acid Oxidation

9/21

@bthw`thcf cg G`ttx @bhor -bcft&(

@_\ bcfwk~rhcf tc @J\ % > \h hr kp{hw`akft tcmxo~caxrhr cg > @_\ tc >@O\

Kfyxjk9 tmhcehf`rk -@bxa Bc@ Rxftmkt`rk(

Acb`thcf9 * c{tk~ jhtcbmcfo~h a jkjn~`fk

* jhtcbmcfo~h a j t~h} - gc~ rmc~t `fo

jkoh{j bm`hf G@ (

_~`fr|c~t cg acfd bm`hf @bxa Bc@

`b~crr hffk~ jhtcbmcfo~h`a jkjn~`fk

Hffk~ jhtcbmcfo~h`a jkjn~`fk hr hj|k~jk`nak

tc @bxa Bc@

B`~~hk~ rxrtkj hr ~kp{h~ko -B`~fhthfk Rm{ttak(

Ht bcfrhrtr cg9

* B`~~hk~ jcakb{ak

* _c kfyxjkr

* Jkjn~`fk t~`fr|c~t |~ctkhf

8/3/2019 Lipid Metabolism- 1 Fatty Acid Oxidation

10/21

B@^FH_HFK RM[__AK

0

>

2

?

8/3/2019 Lipid Metabolism- 1 Fatty Acid Oxidation

11/21

Kfk~dx Xhkao g~cj G@ C}ho`thcfBM2*-BM>(0?*BC*Bc@

7 G@OM>7 F@OM

7 @bktxa Bc@

BM2*BM>BM>*BC*Bc@

BM2*BC*Bc@ % BM2*BC*Bc@ % G@OM> % F@OM

8/3/2019 Lipid Metabolism- 1 Fatty Acid Oxidation

12/21

Kfk~dx Xhkao g~cj G@ C}ho`thcf -bcft&(

C}ho`thcf cg B 07 G@__X @BHO

4 G@OM> ::::6 0? @_\

4 F@OM ::::6 >0 @_\

= @bktxa Bc@ ::::6 87 @_\

@bthw thcf cg tmk @bho bcfr{jkr > @_\

Fkt 0>8 @_\ jcak |k~ jcak cg B07 G ttx @bho

B`~fhthfk

)Rc{~bkr9

* Ohkt`~x

* Rxftmkrhr hf Ahwk~! Ehofkx

) Ctmk~ g{fbthcfr9

* K}|c~t cg n~`fbmko bm`hf bxa d~c{|r g~cj

jhtcbmcfo~h`

*K}b~kthcf cg `bxa d~c{|r tm`t b`ffct nk

jkt`ncahyko hf tmk ncox

8/3/2019 Lipid Metabolism- 1 Fatty Acid Oxidation

13/21

B`~fhthfk Okghbhkfbhkr

Rkbcfo`~x okghbhkfbhkr9Ahwk~ ohrk`rk! j`af{t~hthcf! ~kp{h~kjkftr

Bcfdkfht`a Okghbhkfbhkr9 Kfyxjk! {|t`ek! t{n{a`~ ~k`nrc~|thcf

@nhahtx tc {rk G@ r g{ka

@bb{j{a`thcf cg G&@ `fo

n~`fbmko @bxa d~c{|r hf bkaar

C}ho`thcf cg {fr`t{~`tko G&@9 Cakhb @bhoBM2 -BM>(4*BM : BM -BM>(4*BCvBc@

2 ~c{forCg c}ho`thcf

2 @bktxa Bc@

BM2 -BM>(4*BM : BM BM>*BCvBc@0>9bhr 2

hrcjk~`rk

BM2 -BM>(4 BM>*BM:BM*BCvBc@0>9t~`fr >

8/3/2019 Lipid Metabolism- 1 Fatty Acid Oxidation

14/21

C}ho`thcf cg [fr`t{~ tko G&@9 Ahfcakhb @bho

0=98!0>

2 Bxbakr cg c}ho thcf

2 @bktxa Bc@

0>92&7

Hrcjk~`rk

0>9>&7

@bktxa Bc@

BM2*-BM>(?*BM:BM*BM>*BM>*BC*Bc@ - 0(?*BM:BM*BM:BM*BC*Bc@

^ko{bt`rk

BM2*-BM>(?*BM*BM:BM*BM*BC*Bc@

C}ho`thcf cg G@ htm coo f{jnk~ cg

b`~ncfrBM2*-BM>(02*BCvBc@

Rh} Bxbakr cg c}ho`thcf

C

@BM2*BM>*BvBc@ % 7 @bktxa Bc

\~c|hcfxa Bc@

8/3/2019 Lipid Metabolism- 1 Fatty Acid Oxidation

15/21

333

C

^*BM>*BM>BvBc@*

^*BM:BMBCvBc@*

G@O

G@OM> C>

M>C>

K

C}ho`thcf cg Wk~x Acfd Bm`hf G`ttx @bho hf \k~c}hrcjkr9

K9 G@O Bcft`hfhfd C}ho`rk

8/3/2019 Lipid Metabolism- 1 Fatty Acid Oxidation

16/21

C}ho`thcf cg G`ttx @bhorBM2 BM2a a

BM2-BM* BM>*BM>*BM>(2*BM*BM>*BCC*

BM2 BM2 CMa a a

BM2-BM* BM>*BM>*BM>(2*BM* BM*BCC*

BM2 BM2a aBM2-BM* BM>*BM>*BM>(2* BM*BCC

* % BC>

C}ho`thcf cg G`ttx @bhor -cwk~whk(BM2 -BM>(f*BM>*BM>* BCC

*

BM2 -BM>(f *BM>*BM>*BC vBc@

C

BM2 -BM>(f *B*BM>*BC vBc@

BM2 -BM>(f *BC vBc@ % BM2*BC vBc@

8/3/2019 Lipid Metabolism- 1 Fatty Acid Oxidation

17/21

Ektcfk Ncohkr

33333

Ektcfk Ncohkr

Rxftmkrhr9

Hf Ahwk~

\~kb{~rc~9

@bktxa Bc@

@t mhdm ~`tk o{~hfd9

*G`rthfd

* [fbcft~caako Oh`nktkr Jkaaht{r

8/3/2019 Lipid Metabolism- 1 Fatty Acid Oxidation

18/21

Fkt ^k`bthcf 33

> @bktxa Bc@

@bktc`bkt`tk % > Bc@

Fkt ^k`bthcf

> @bktxa Bc@ @bktc`bkt`tk % > Bc@

@ow`ft`dk -\{~|crk( 3

* Gc~ tmk ahwk~

* Gc~ tmk thrr{kr

8/3/2019 Lipid Metabolism- 1 Fatty Acid Oxidation

19/21

\`ajhthb @bho

@bktxa Bc@

4G@OM>%4F@OM

=Bc@

C}`ac`bkt`tk

Bc@

Da{bcrkEktcfk ncohkr

BC>

BC>

Hfb~k`rk K}b~kthcf hf

[~hfk `r

Rcoh{j R`at

Acrr cg `tk~

Okmxo~`thcf

8/3/2019 Lipid Metabolism- 1 Fatty Acid Oxidation

20/21>

[rk cg Ektcfk Ncohkr nx \k~h|mk~`a _hrr{kr9

Rekakt`a J{rbak! B`~oh`b J{rbak `fo

Hf N~`hf O{~hfd \~cacfdko G`rthfd -Rt`~w`thcf(

8/3/2019 Lipid Metabolism- 1 Fatty Acid Oxidation

21/21

G{ka jkt`ncahrj hf rt`~w`thcf

0;