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1 Feb, 2016 Israeli Digital Health: Investors Perspective Levi Shapiro, Founder, mHealth Israel
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Israeli Digital Health: Investors Perspective€¦ · funded startups onferences: Pavilion ... Israel- Venture Capital ... Herzliya Tel Aviv Jerusalem Factors Enabling Israel’s

Aug 02, 2018

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Page 1: Israeli Digital Health: Investors Perspective€¦ · funded startups onferences: Pavilion ... Israel- Venture Capital ... Herzliya Tel Aviv Jerusalem Factors Enabling Israel’s

1 Feb, 2016

Israeli Digital Health: Investors Perspective Levi Shapiro, Founder, mHealth Israel

Page 2: Israeli Digital Health: Investors Perspective€¦ · funded startups onferences: Pavilion ... Israel- Venture Capital ... Herzliya Tel Aviv Jerusalem Factors Enabling Israel’s

mHealth Israel: Join Our Community

2

Database of 250+ funded startups

Pavilion: HIMSS, Medica Conferences: June and Feb

Monthly Meetups

Page 3: Israeli Digital Health: Investors Perspective€¦ · funded startups onferences: Pavilion ... Israel- Venture Capital ... Herzliya Tel Aviv Jerusalem Factors Enabling Israel’s

Thesis: 3rd Wave of Digital Health Investment

Wave I Remote Telemedicine

Wave II Enterprise Software

Wave III Consumerization of Big Data

Trigger Obamacare, 2009

Example: SHL; Natali acquired by Jinpeng-Sanpower 2014, ~$100M

dbMotion -acquired by Allscripts 2013, $235M AeroScout -acquired by SBD 2012, $240M iMDSoft -acquired by TPG 2012, $80M

250+ Israeli digital healt startups Sensors, applications, big-data, machine-learning, AI, etc

Page 4: Israeli Digital Health: Investors Perspective€¦ · funded startups onferences: Pavilion ... Israel- Venture Capital ... Herzliya Tel Aviv Jerusalem Factors Enabling Israel’s

Agenda

4

Investment Thesis Israel- Venture Capital Background Israel Health Sector Israel Digital Health Investment

Page 5: Israeli Digital Health: Investors Perspective€¦ · funded startups onferences: Pavilion ... Israel- Venture Capital ... Herzliya Tel Aviv Jerusalem Factors Enabling Israel’s

Haifa

Herzliya

Tel Aviv

Jerusalem

Factors Enabling Israel’s Unique Healthcare Ecosystem

Rehovot

Yokneam

Beer Sheva

Petach Tiqva

• Seven university-associated and five hospital-linked

technology transfer organizations (TTO) provide a valuable

bridge to connect researchers and early-stage projects with

both investors and partnerships with multinational

corporations.

• The technological incubator network houses up to 15

companies each and provides them with a full suite of

services and business development, as well as funding of

approximately $500,000 for the first 2-3 years of their lives.

State

Industry

Academic & med institutions

VCs , Accelerators Angels &Incubators Skilled

Workforce

Start ups

Total of 6,019 companies 1,159 IT &enterprise SW

1,018 Life Science Startups

Out of which 550 in Medical Devices and 210 in Digital Health

Power Of

Distance Dynamic Open

Culture

Informal yet

Efficient Society

Strong connections

Direct Feedback

Page 6: Israeli Digital Health: Investors Perspective€¦ · funded startups onferences: Pavilion ... Israel- Venture Capital ... Herzliya Tel Aviv Jerusalem Factors Enabling Israel’s

Building Block I: R&D Allocation

6

Country Rank 1st 2nd 3rd 4th

Business expenditure on R&D Israel Korea Japan Finland

Total R&D Personnel in Business Per Capita

Israel

Taiwan Luxemburg Denmark

Total Expenditure on R&D Korea Israel Finland Sweden

Nobel Prizes Per Capita Switzerland Norway Israel Sweden

Funding for technological development

Finland USA Singapore Israel

Development and application of technology

Finland Singapore Switzerland Israel

Population: 8 M NL: 17M, MA: 7 M GDP (nominal) per capita: 38K$ NL: 52 K$ IT: 35 K$ Unemployment rate: 5.9 % US: 5.8 % IT: 12.6 % Human Dev. Index (Life expt., school, GDP) #19 (out of 187) NL: #4, US #5, UK #14, IT #26)

Page 7: Israeli Digital Health: Investors Perspective€¦ · funded startups onferences: Pavilion ... Israel- Venture Capital ... Herzliya Tel Aviv Jerusalem Factors Enabling Israel’s

R&D Encourages Higher Quality Innovation

7

Level of Innovation

Qu

ality

of

Sc

ien

tifi

c R

es

ea

rch

Page 8: Israeli Digital Health: Investors Perspective€¦ · funded startups onferences: Pavilion ... Israel- Venture Capital ... Herzliya Tel Aviv Jerusalem Factors Enabling Israel’s

Building Block II: Skilled Workforce

8

Proportion of Population with Bachelors Degree Among Life Sciences Hubs

Page 9: Israeli Digital Health: Investors Perspective€¦ · funded startups onferences: Pavilion ... Israel- Venture Capital ... Herzliya Tel Aviv Jerusalem Factors Enabling Israel’s

Building Block III: International R&D Centers Are a Lifeline for Local Tech Industry

9

Page 10: Israeli Digital Health: Investors Perspective€¦ · funded startups onferences: Pavilion ... Israel- Venture Capital ... Herzliya Tel Aviv Jerusalem Factors Enabling Israel’s

Role of MNC’s: Case Study- SAMSUNG

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Page 11: Israeli Digital Health: Investors Perspective€¦ · funded startups onferences: Pavilion ... Israel- Venture Capital ... Herzliya Tel Aviv Jerusalem Factors Enabling Israel’s

Agenda

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Investment Thesis Israel- Venture Capital Background Israel Health Sector Israel Digital Health Investment

Page 12: Israeli Digital Health: Investors Perspective€¦ · funded startups onferences: Pavilion ... Israel- Venture Capital ... Herzliya Tel Aviv Jerusalem Factors Enabling Israel’s

Israeli VC Funds: More Money Flooding into the Market

12

Three Key Ingredients of Israel Success Israel Venture Industry Israel Health Sector Israel Digital Health Investment

IVC, 2014

Page 13: Israeli Digital Health: Investors Perspective€¦ · funded startups onferences: Pavilion ... Israel- Venture Capital ... Herzliya Tel Aviv Jerusalem Factors Enabling Israel’s

Agenda

13

Investment Thesis Israel- Venture Capital Background Israel Health Sector Israel Digital Health Investment

Page 14: Israeli Digital Health: Investors Perspective€¦ · funded startups onferences: Pavilion ... Israel- Venture Capital ... Herzliya Tel Aviv Jerusalem Factors Enabling Israel’s

GDP Allocation: 7.5% VS 18% of GDP

14

Page 15: Israeli Digital Health: Investors Perspective€¦ · funded startups onferences: Pavilion ... Israel- Venture Capital ... Herzliya Tel Aviv Jerusalem Factors Enabling Israel’s

Health in Israel: Relatively Good Outcomes

15 OECD, 2012

Page 16: Israeli Digital Health: Investors Perspective€¦ · funded startups onferences: Pavilion ... Israel- Venture Capital ... Herzliya Tel Aviv Jerusalem Factors Enabling Israel’s

CVD Mortality in Israel

16 OECD, 2011

Israel Ministry of Health, 2013

Ischemic Heart Disease, Mortality Rates

Page 17: Israeli Digital Health: Investors Perspective€¦ · funded startups onferences: Pavilion ... Israel- Venture Capital ... Herzliya Tel Aviv Jerusalem Factors Enabling Israel’s

Comparatively Efficient Health System Optimization

17 Israel, MOH; OECD

Page 18: Israeli Digital Health: Investors Perspective€¦ · funded startups onferences: Pavilion ... Israel- Venture Capital ... Herzliya Tel Aviv Jerusalem Factors Enabling Israel’s

Factors That Drove Israel Toward Prioritizing Digital Healthcare Adoption

18

Multi-Morbidity

Aging

Complexity

Resources Shortage

Page 19: Israeli Digital Health: Investors Perspective€¦ · funded startups onferences: Pavilion ... Israel- Venture Capital ... Herzliya Tel Aviv Jerusalem Factors Enabling Israel’s

HMOs bring 24 YEARS of universal, longitudinal EMR data that startups can access

19

Example from Clalit, largest HMO with 54% market share

Page 20: Israeli Digital Health: Investors Perspective€¦ · funded startups onferences: Pavilion ... Israel- Venture Capital ... Herzliya Tel Aviv Jerusalem Factors Enabling Israel’s

International Recognition: OECD

20

“ Israel’s community‐focused information system sets an international benchmark in excellence and demonstrates commitment to quality monitoring and improvement. ”

OEDC Report, 2012

Page 21: Israeli Digital Health: Investors Perspective€¦ · funded startups onferences: Pavilion ... Israel- Venture Capital ... Herzliya Tel Aviv Jerusalem Factors Enabling Israel’s

Agenda

21

Investment Thesis Israel Venture Industry Israel Health Sector Israel Digital Health Investment

Page 22: Israeli Digital Health: Investors Perspective€¦ · funded startups onferences: Pavilion ... Israel- Venture Capital ... Herzliya Tel Aviv Jerusalem Factors Enabling Israel’s

Israel Life Sciences Industry by Sub-Sectors

22 IATI, 2015

Page 23: Israeli Digital Health: Investors Perspective€¦ · funded startups onferences: Pavilion ... Israel- Venture Capital ... Herzliya Tel Aviv Jerusalem Factors Enabling Israel’s

Source: mHealth Israel Database

28

48

Page 24: Israeli Digital Health: Investors Perspective€¦ · funded startups onferences: Pavilion ... Israel- Venture Capital ... Herzliya Tel Aviv Jerusalem Factors Enabling Israel’s

mHealth Israel Database Breakouts

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Page 25: Israeli Digital Health: Investors Perspective€¦ · funded startups onferences: Pavilion ... Israel- Venture Capital ... Herzliya Tel Aviv Jerusalem Factors Enabling Israel’s

Medivizor: “Health Information – Personalized”

https://medivizor.com/

http://bit.ly/1RSv3uf

http://bit.ly/1mTipOR

http://bit.ly/1mTipOR

Improve the lives of people with serious or chronic medical conditions and of those who care for them. Effectively apply software and the social web to the field of health for the betterment of humanity.

Page 26: Israeli Digital Health: Investors Perspective€¦ · funded startups onferences: Pavilion ... Israel- Venture Capital ... Herzliya Tel Aviv Jerusalem Factors Enabling Israel’s

Medivizor: Personalized Healthcare

Source: Medivizor

Page 27: Israeli Digital Health: Investors Perspective€¦ · funded startups onferences: Pavilion ... Israel- Venture Capital ... Herzliya Tel Aviv Jerusalem Factors Enabling Israel’s

A 3-Tier Approach to Personalizing Information

Source: Medivizor

Understandable, relevant, trustworthy and proactive personal information gathering

Page 28: Israeli Digital Health: Investors Perspective€¦ · funded startups onferences: Pavilion ... Israel- Venture Capital ... Herzliya Tel Aviv Jerusalem Factors Enabling Israel’s

MOBILE ODT: “Using A Smartphone To Detect Cancer”

https://www.mobileodt.com/

Page 29: Israeli Digital Health: Investors Perspective€¦ · funded startups onferences: Pavilion ... Israel- Venture Capital ... Herzliya Tel Aviv Jerusalem Factors Enabling Israel’s

450,000

New cases every year

270,000

Deaths every year

Cervical Cancer Worldwide

Page 30: Israeli Digital Health: Investors Perspective€¦ · funded startups onferences: Pavilion ... Israel- Venture Capital ... Herzliya Tel Aviv Jerusalem Factors Enabling Israel’s

MobileODT’s EVA $1,500 Today’s Colposcope

$15,000

Visual Assessment of the Cervix

Page 31: Israeli Digital Health: Investors Perspective€¦ · funded startups onferences: Pavilion ... Israel- Venture Capital ... Herzliya Tel Aviv Jerusalem Factors Enabling Israel’s

• Case review and oversight

• Aggregated data on clinicians,

procedures, treatment rates

• Drilldown to focus on local, regional,

national, or international levels

Online Monitoring and Evaluation

Page 32: Israeli Digital Health: Investors Perspective€¦ · funded startups onferences: Pavilion ... Israel- Venture Capital ... Herzliya Tel Aviv Jerusalem Factors Enabling Israel’s

The Network Effect

Machine Learning

Expert

Screener

App

Page 33: Israeli Digital Health: Investors Perspective€¦ · funded startups onferences: Pavilion ... Israel- Venture Capital ... Herzliya Tel Aviv Jerusalem Factors Enabling Israel’s

VoiciTT

Page 34: Israeli Digital Health: Investors Perspective€¦ · funded startups onferences: Pavilion ... Israel- Venture Capital ... Herzliya Tel Aviv Jerusalem Factors Enabling Israel’s
Page 35: Israeli Digital Health: Investors Perspective€¦ · funded startups onferences: Pavilion ... Israel- Venture Capital ... Herzliya Tel Aviv Jerusalem Factors Enabling Israel’s
Page 36: Israeli Digital Health: Investors Perspective€¦ · funded startups onferences: Pavilion ... Israel- Venture Capital ... Herzliya Tel Aviv Jerusalem Factors Enabling Israel’s

https://vimeo.com/98136263