Interpenetrating Networks for Delivery Systems Client: Professor W. John Kao, School of Pharmacy & Department of Biomedical Engineering Advisor: Professor Naomi Chesler, Department of Biomedical Engineering Ashley Huth Claire Flanagan Adam Rieves Jon Sass
Interpenetrating Networks for Delivery Systems. Client: Professor W. John Kao, School of Pharmacy & Department of Biomedical Engineering Advisor: Professor Naomi Chesler, Department of Biomedical Engineering Ashley Huth Claire Flanagan Adam Rieves Jon Sass. Overview. Background Information - PowerPoint PPT Presentation
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Interpenetrating Networks for Delivery Systems
Client: Professor W. John Kao, School of Pharmacy & Department of Biomedical Engineering
Advisor: Professor Naomi Chesler, Department of Biomedical Engineering
Ashley HuthClaire FlanaganAdam Rieves
Jon Sass
Overview• Background Information
• Interpenetrating Networks (IPNs)• Competing Products• Past Semester
• Problem Statement• Design Requirements• Proposed Designs• Future Work• Questions
Problem Statement• To design a novel delivery mechanism
to reconstitute the components of an interpenetrating network (IPN).
– Biocompatible– Moist healing environment– Conforms to irregular wounds– Covers large surface area wounds– Delivers drug cocktails
• Issues– Heat– Uneven administration– Lengthy application process
Current Administration TechniqueIngredients/drug(s) in singlecontainer
Mix1
Cover5
Heat2
3 Inject Syringe is use to administer solution
4 Curein 30 sec to obtain a rubbery film
6 Sustained Releasewhile the IPN biodegrades
Day7Day
3Day1
7 Clean
*Kao, W.J
Components•pegDA•Gelatin•Photoinitator•Water
Last Semester• Focused on optimizing IPN solution
composition– Gelatin dissolution impacts efficacy & administration of IPNs– Integrated laboratory & design-based research
• Developed IPN recipe • Modified IPN administration
This Semester• Administration technique • Product packaging• Further laboratory research
Design Requirements• Minimal preparation and effort required to
administer the IPN• Compartmentalization • Even spray pattern• Uniform solution• Straightforward mixing procedure• Disposable • Can be sterilized • Low-cost• Few parts
Competing Products• Duoject Medical Systems Inc.
– Inter-Vial• Debiotech
– Clip’n’ject• U-Mix
– Travel Bottle• Hansplast
– Spray Bandage
Design 1: Syringe • Liquid in plunger• Powder stored in
barrel• Mechanism to release
liquid into powder• Hand mixing• Hand powered
delivery• Luer-Lock spray tip
Design 1: Syringe• Pros
– All in one packaging– Easy application– Controllable spray rate
• Cons– Custom manufacturing required– Moving parts
Design 2: Pressurized Bottle• Manual pressure
vacuum• Unique cap design
– Facilitates stirring mechanism
• Perforated seal
Design 2: Pressurized Bottle• Pros
– Parts readily available– Few modifications necessary– Spray is sustained for approx. 20 sec
• Cons– Pressure building is laborious– All parts must be packaged separately– Pressure feature comes at a cost ($14)– Only one size is available
Design 3: Spray Bottle
• Threaded straw • Blades puncture inner
container• Single pump, single
spray• Includes mixing
mechanism
Design 3: Spray Bottle• Pros
– Incorporates mixing mechanism– Provides slow release of photo-initiator
• Cons– Laborious application technique– Non-standard parts