Instituto de Tecnologia Química e Biológica Universidade Nova de Lisboa The place:

Instituto de Tecnologia Química e Biológica

Universidade Nova de Lisboa

The place:

OEIRAS

The place:

Instituto de Tecnologia Química e Biológica

Universidade Nova de Lisboa

The place:

Research divisons: - Chemistry

- Biology

- Biological chemistry

- Technology

Supercritical fluid processes

The people:Prof. Dr. Manuel Nunes da Ponte

Prof. Ana Aguiar Ricardo*

Prof. Pedro Simões*

Dr. Catarina Duarte

Anna Banet

Joana Fonseca

Rui Ruivo

Teresa Casimiro*

Vesna Najdanovic-Visak

Rita Duarte

Ana Serbanovic

Raquel Sousa

Ana Matias

Ana Nunes

Post Doc:

Ph D students:

Junior researchers: *REQUIMTE –

Research Center of Excellence

The people:

Biarritz 2003

Versailles 2003

The work – Supercritical Fluid Processes

- Extraction from solids

- Fraccionation of complex liquid mixtures (liquid –

liquid extraction)

- Emulsions for protein transport

-Chemical Reaction: hydrogenation, oxidation with

air, polymerization

- Impregnation of polymeric matrixes with

pharmaceuticals

- Phase Behavior Studies: solubility, VLE, polymer

sorption and swelling

The work – Supercritical Fluid Processes

Extraction from solids

Laboratory scale

Pilot plant

P PP

T

*

*

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PP

The work – Supercritical Fluid Processes

Fraccionation of complex liquid mixtures

Emulsions for protein transport

Pilot plant

The work – Supercritical Fluid Processes

Liquid – liquid extraction

The work – Supercritical Fluid Processes

Chemical Reaction

Hydrogenation/Oxidation

Polymerization

The work – Supercritical Fluid Processes

Impregnation of polymeric matrixes with pharmaceuticals

TC

VacP

P

Extractioncell

Impregnation cellT

Meteringvalve

CO2 pump

CO2

c

P

Liquidpump

V1

The work – Supercritical Fluid Processes

Phase Behaviour Studies: Solubility measurements

PTC

TC

CO2

CO2 Pump

P

VacAtm

1

2

C

34

T

B

5

The work – Supercritical Fluid Processes

PT

Vac AtmPT

CO2 pump

TC

TC

1

2

4

3B

5

(1) CO2 compressor; (2) rupture disk; (3) thermostatic water bath; (4) six port sampling HPLC-valve; (5) HPLC-valve; (PT) pressure transducer; (TC) temperature controller; (C) equilibrium cell with sapphire windows; (T) glass trap; (B) expansion calibrated cylinder.

Phase Behaviour Studies: vapour-liquidequilibria

The work – Supercritical Fluid Processes

TCP

Atm

Vac

High pressurecell

CO2 pump

Phase Behaviour Studies: polymer sorption and swelling

The work – Supercritical Fluid Processes

Relevant recent publications:

- “Production of phytosqualene and phytosqualane compounds, useful for e.g. pharmaceutical/cosmetic industries, comprises integral carbon dioxide extraction, purification and optional hydrogenation of saponified and dried residues”, DE Patent 19934834 (2001). Inventors: Bus, A. Mueller, P. Swidersky, P. Bondioli, P. Simões, J.A.C. Fernandes

- "An apparatus for high-pressure VLE measurements using a static mixer. Results for (CO2 + limonene + citral) and (CO2 + limonene + linalool)" J. Fonseca, P.Simoes, M. Nunes da Ponte J. Supercritical Fluids, 2003, 25, 7-17

-- “Supercritical CO2 - induced Phase Changes in Ionic Liquid + Water + Ethanol Solutions: Application to Biphasic Catalysis” V. Najdanovic-Visak, A. Serbanovic, J. M.S.S. Esperança, H. J.R. Guedes,L.P.N. Rebelo, M. Nunes da Ponte ChemPhysChem 2003, 4, 1-6

-- “Fractionation of Edible Oil Model Mixtures by Supercritical Carbon Dioxide in a Packed Column – Part II: A Mass Transfer Study”, R. Ruivo, M.J. Cebola, P.C. Simões, M. Nunes da Ponte, Ind.Eng.Chem.Res., 2002, 41(9), 2305-2315 .

- “Phase Equilibrium for Capsaicin + Water + Ethanol + Supercritical Carbon Dioxide.” C. M. M. Duarte, M. Crew, T. Casimiro, A. Aguiar Ricardo, M. Nunes da Ponte J. Supercritical Fluids, 2002, 22, 87-92

The work – Supercritical Fluid Processes

On-going projects:

- “EXTEN-Extraction and encapsulation of natural products” Program FAIR-ST8009 (Contract nºCT96-1075; c/ DG XII - UE)

- ”Preparation of controlled release systems for ophthalmic applications”, Program Sapiens 2001 (Contract nºPOCTI/FCB/38213/2001)

- “Natural antioxidants” (POE –Medida 3.1,Contract: 03/2003/00068/192).

- … … …

Instituto de Tecnologia Química e Biológica

Universidade Nova de Lisboa

The place: