Innovations in Animal Feed (Additives)Innovations in Animal Feed (Additives) A combination of feed additives and feeding more precisely can reduce the need of antibiotics drastically

PACCARB, Washington27th February 2020

Leon Marchal, PhDInnovation Director

Innovations in Animal Feed (Additives)

Dupont Animal Nutrition, part of Nutrition & Biosciences

Porzyme® & Avizyme®

First species-specific multi-enzyme solutions

1984Firstß-glucanaseenzyme

2006Avicheck®

Phycheck®

services

Betafin®First betaine for Choline sparing

2003

Phyzyme® XPFirst E. coliphytase

2007

Phyzyme® XP TPTPorcheck®

software tool

1988

1997Avizyme® 1500Carbohydrase/ protease blend

MicroTreatP ProvalenProbiotics for poultryCSI - Gut microbial analysis service for poultry and swine

2008

1982

Feed enzyme development begins

1979 2011Axtra® XBAxtra® XAPCarbohydrasesfor complex diets

2018

2014OptimizeFeed® Service

2015

Syncra®AVIenzyme-probiotic combination

2019Enviva® PROProbiotic for broilersSyncra® SWIAdaptive protease/ probiotic solution

2013

Axtra® PHYFastest phytase

Axtra® PROLeadingprotease

Enviva® EO launchphytogenic blend

2010

2017CSI 2.0Fecal microbial analysis service for poultry and swine

2

Animal Nutrition group of Wageningen University

Fundamental understanding ofnutritional processes and

the effects on the health, growth, welfareand longevity of animals.

What needs to happen forantibiotic (growth promotor) free production

Nutrition

Hygiene

Gut & Immune Function Microbiome

3

Imag

e: T

ed

Feed structure – better organ development

Images: ForFarmers

ain15% whole gr

Pelleting

Experimental groupControl (starconcept 0%)

Trial (starconcept 15%)100% diet

Pelleting

Grinding Grinding

100% diet

Adding a few % fiber structure toa broiler diet

Image:Nutreco

ReviewsThe gizzard: function, influence of diet structure and effects on nutrient availability

B.SVIHUSDepartment of Animal and Aquacultural Sciences,Norwegian University of Life Sciences, World's Poultry Science Journal, Vol. 67, June 2011

Better organ development Beneficial for ‘right flora in

the right place’ Same or better feed

conversion

4

Similar feed conversion Better stomach function Less prone to

Salmonella infections

Stomach Score

Less overfeeding of protein• Protein digestion is generally 60-90%• Younger animals have generally lower digestibility• Raw material quality also varies in practice

All the protein that is not digested in the small intestine is potentially

fermented by pathogens in the large intestine

5Protein digestion kinetics in pigs and poultry, H.Chen (2017)

Hydrolytic enzymes improve (protein) digestibility• Phytases are the most commonly used enzyme, globally

• Competition drives increased efficacy & reduced costs higher inclusion levels

7877

79

8182

83

PC NC 250 500 1000 2000

Phytase, FTU/kg

%

Amin

o ac

id d

iges

tibilit

y

P linear < 0.0001

179

180

181

182

183

184

185

186

187

0 250 500 750 1000 1250 1500 1750 2000

Phytase dose (FTU/kg feed)

E-ColiButtiauxella

Other enzymes used in animal production: xylanases, beta-glucanases, amylases, proteases6

Animal Feed Science and Technology 253 (2019) 166–180J. Anim. Sci. 2019.97:2524–2533Am

ino

acid

dig

estib

ility

(g/k

g di

et)

DFM / probiotic maintain general gastrointestinal health

7

C

d

ompetitive exclusion

Compete for ecological

niches

Stimulate

Compete for nutrients

efense by host

Immunomodulation

Regulate proinflammatory

cytokines

Stimulate immune response

Enhance beneficial microbiota

Inhibition of virulence factors

Decrease luminal pH

Secrete bacteriocidalmolecules

Direct microbial

interactions

What are DFM / probiotics capable of?

8

Support the development of a healthy gut (immune system, gut function and microbiota development)

Support the recovery post-infection

Can have antimicrobial activity against other microbes (typically broad spectrum)

Add to the overall fermentation and can produce beneficial metabolites

NOT a drug

NOT a true replacement for therapeutic antibiotics

Probiotics can Probiotics are

Innovations in Animal Feed (Additives)

A combination of feed additives and feeding more precisely can reduce the need of antibiotics drastically (EU and market examples).

Further antibiotic reduction needs the development of more consistent feed additive solutions.

Key is increasing the robustness of the animals.

We should conserve the efficacy of antibiotics for when they are really needed when animals despite all measures become sick (animal welfare).

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