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Inflammation and Hypersensitivity Inflammation and Hypersensitivity
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Inflammation and Hypersensitivity. I.Now that we know basics about varying forms of cellular and humoral cascades, ready to talk more about dysfunction.

Jan 18, 2016

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Brenda Shields
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Page 1: Inflammation and Hypersensitivity. I.Now that we know basics about varying forms of cellular and humoral cascades, ready to talk more about dysfunction.

Inflammation and HypersensitivityInflammation and Hypersensitivity

Page 2: Inflammation and Hypersensitivity. I.Now that we know basics about varying forms of cellular and humoral cascades, ready to talk more about dysfunction.

I. Now that we know basics about varying forms of cellular and humoral

cascades, ready to talk more about dysfunction

A. Inflammation can be cellular mediated and/or

humoral and can involve complement and

clotting cascade

B. Text goes over varying complement pathways,

can be classical or alternative.

Page 3: Inflammation and Hypersensitivity. I.Now that we know basics about varying forms of cellular and humoral cascades, ready to talk more about dysfunction.

Players in responses

• The palyers are the same essentially as in blood section and immuno section

Page 4: Inflammation and Hypersensitivity. I.Now that we know basics about varying forms of cellular and humoral cascades, ready to talk more about dysfunction.
Page 5: Inflammation and Hypersensitivity. I.Now that we know basics about varying forms of cellular and humoral cascades, ready to talk more about dysfunction.

These are usually first to inflammation Both in serum and mucosal, will function much as macrophages

Page 6: Inflammation and Hypersensitivity. I.Now that we know basics about varying forms of cellular and humoral cascades, ready to talk more about dysfunction.
Page 7: Inflammation and Hypersensitivity. I.Now that we know basics about varying forms of cellular and humoral cascades, ready to talk more about dysfunction.

Macrophages are later arriving

Page 8: Inflammation and Hypersensitivity. I.Now that we know basics about varying forms of cellular and humoral cascades, ready to talk more about dysfunction.

Monocytes are close relatives and are more plasma oriented

Page 9: Inflammation and Hypersensitivity. I.Now that we know basics about varying forms of cellular and humoral cascades, ready to talk more about dysfunction.

But much of symptomology comes from these

As they release 5HT and histamines and ECP-A

Page 10: Inflammation and Hypersensitivity. I.Now that we know basics about varying forms of cellular and humoral cascades, ready to talk more about dysfunction.

These are usually last even after macros. So if see probably chronic condition

Page 11: Inflammation and Hypersensitivity. I.Now that we know basics about varying forms of cellular and humoral cascades, ready to talk more about dysfunction.

Inflammation has a few aspects

• Is based usually on a response to parasites (may be how it evolved)• Uses IgEs a lot and mast cells and eosinophiles• May also use complement• If long term can encapuslate using clotting cascade

Page 12: Inflammation and Hypersensitivity. I.Now that we know basics about varying forms of cellular and humoral cascades, ready to talk more about dysfunction.
Page 13: Inflammation and Hypersensitivity. I.Now that we know basics about varying forms of cellular and humoral cascades, ready to talk more about dysfunction.
Page 14: Inflammation and Hypersensitivity. I.Now that we know basics about varying forms of cellular and humoral cascades, ready to talk more about dysfunction.

Now Hypersensitivity

• Four types:• I- IgE mediated by allergen• II-tissue specific• III-immune complex• IV-cell-mediated

Page 15: Inflammation and Hypersensitivity. I.Now that we know basics about varying forms of cellular and humoral cascades, ready to talk more about dysfunction.

Type I

• Big Player is histamine which has opposing effects based on which subtype of receptor is activated.

• H1 tend to increase inflammation• H2 tend to ameliorate• H3 are more CNS derived

Page 16: Inflammation and Hypersensitivity. I.Now that we know basics about varying forms of cellular and humoral cascades, ready to talk more about dysfunction.

Histamine Receptors

G-pr- IP3

cAMP

Immune recruitment

Bronchial constriction

Immune silencing via Ts

Gastric secretion

H1

H2

Page 17: Inflammation and Hypersensitivity. I.Now that we know basics about varying forms of cellular and humoral cascades, ready to talk more about dysfunction.

Allergy response

Allergensensitization

IgEMasteosins

H1

Page 18: Inflammation and Hypersensitivity. I.Now that we know basics about varying forms of cellular and humoral cascades, ready to talk more about dysfunction.

II

HLA mismatch CD8

MHCII

Attack complex

Page 19: Inflammation and Hypersensitivity. I.Now that we know basics about varying forms of cellular and humoral cascades, ready to talk more about dysfunction.

Mechanisms of anti self

• Phagocytosis after opsinization

• Complementation

• Tc destruction

• Ab blockade of receptor subtypes

Page 20: Inflammation and Hypersensitivity. I.Now that we know basics about varying forms of cellular and humoral cascades, ready to talk more about dysfunction.

III

allergen

Attack complex

complexation

Page 21: Inflammation and Hypersensitivity. I.Now that we know basics about varying forms of cellular and humoral cascades, ready to talk more about dysfunction.

IV

CD4 or CD8

If CD4 termed delayed

antigen

Antigen presenting cell destroyed either directly or after antigen presentation by host