Infection and Immunity...Kuby Immunology, 7th Edition Immune Response Against Helminths Delves, Martin, Burton, Roitt. Roitt’s Essential Immunology, 12th Edition. Immune Evasion

Infection and Immunity

Nesmiyanov P.P., Associate Prof.,

Immunology and Allergy Department

Volgograd State Medical University

Outline

1. Introduction 2. Overview of Antibacterial Immunity/Evasion 3. Overview of Antiviral Immunity/Evasion 4. Overview of Antifungal Immunity/Evasion 5. Overview of Immunity to Parasites - Protozoa - Helminths - Ectoparasites (ticks, mites)

Introduction

Chronic infections with persistent pathogens such as helminths, mycobacteria, Plasmodium, and hepatitis viruses affect more than a third of

the human population

Worldwide influenza annual epidemics result in about 3-5 million cases of severe illness, and about 250 000 to

500 000 deaths.

In 2010, malaria caused an estimated 660 000 deaths (with an uncertainty range of 490 000 to 836 000)

In 2011, 8.7 million people fell ill with TB and 1.4 million died from TB.

There were approximately 35.3 million people living with HIV in 2012

Facts (WHO):

…

Introduction

Owen, Punt, Stranford. Kuby Immunology, 7th Edition

Adaptive Immune Response to Extracellular Bacteria

Abbas , Lichtman, Pillai. Cellular and Molecular Immunology, 7th Edition.

Injurious Effects of Immune Response

Abbas , Lichtman, Pillai. Cellular and Molecular Immunology, 7th Edition.

*SEB – Staphilococcal Enterotoxin B

Dendritic cells and Infection

Jacques Banchereau. The Long Arm of the Immune System. Scientific American 18, 56 - 63 (2008)

Immune Evasion by Extracellular Bacteria

Abbas , Lichtman, Pillai. Cellular and Molecular Immunology, 7th Edition.

Immune Evasion by Extracellular Bacteria

Immune Evasion by Extracellular Bacteria

Delves, Martin, Burton, Roitt. Roitt’s Essential Immunology, 12th Edition.

Immune Evasion by Extracellular Bacteria

Delves, Martin, Burton, Roitt. Roitt’s Essential Immunology, 12th Edition.

Immune Response to Intracellular Bacteria (Listeria)

Abbas , Lichtman, Pillai. Cellular and Molecular Immunology, 7th Edition.

Immune Response Against Viruses

Abbas , Lichtman, Pillai. Cellular and Molecular Immunology, 7th Edition.

Mechanisms of Induction of Type I Interferons by West Nile Virus

Mehul S. Suthar, Michael S. Diamond & Michael Gale Jr. West Nile virus infection and immunity. Nature Reviews Microbiology 11, 115-128 (February 2013)

West Nile virus and Immunity

Mehul S. Suthar, Michael S. Diamond & Michael Gale Jr. West Nile virus infection and immunity. Nature Reviews Microbiology 11, 115-128 (February 2013)

Immune Evasion by Viruses

Abbas , Lichtman, Pillai. Cellular and Molecular Immunology, 7th Edition.

Immune Evasion by Viruses (continued)

Kenneth Murphy. Janeway's Immunobiology, Eighth Edition.

Antigenic Drift and Shift

Kenneth Murphy. Janeway's Immunobiology, Eighth Edition.

Influenza Virus

Owen, Punt, Stranford. Kuby Immunology, 7th Edition

Influenza Virus

Owen, Punt, Stranford. Kuby Immunology, 7th Edition

Antigenic Shift

Abbas , Lichtman, Pillai. Cellular and Molecular Immunology, 7th Edition.

Inhibition of Antigen Processing and Presentation by Viruses

Abbas , Lichtman, Pillai. Cellular and Molecular Immunology, 7th Edition.

Persistence and Reactivation of Herpesviruses

Penkert, Rhiannon R; Kalejta, Robert F. Tegument protein control of latent herpesvirus establishment and animation. Herpesviridae Vol. 2 Issue 1, 2011

Animation/Reactivation of Herpesviruses

Penkert, Rhiannon R; Kalejta, Robert F. Tegument protein control of latent herpesvirus establishment and animation. Herpesviridae Vol. 2 Issue 1, 2011

Cell types in Which HV Initiate Infection/Latency

Penkert, Rhiannon R; Kalejta, Robert F. Tegument protein control of latent herpesvirus establishment and animation. Herpesviridae Vol. 2 Issue 1, 2011

Immune Response to Fungi

Abbas , Lichtman, Pillai. Cellular and Molecular Immunology, 7th Edition.

Immune Response to Fungi

Delves, Martin, Burton, Roitt. Roitt’s Essential Immunology, 12th Edition.

Immune Response to Fungi

Brad Spellberg. Antifungal Immune Response. The Scientist, 2011

Immune Response to Fungi

Uday Kishore, Suhair M. Abozaid and Mohammed N. Al-Ahdal. Anti-Fungal Innate and Adaptive Immune Responses. From the book Microbial Pathogenesis: Infection and Immunity, 2013 (Landes Biosciences and Springer)

Immune Response Against Parasites

Abbas , Lichtman, Pillai. Cellular and Molecular Immunology, 7th Edition.

Immune Response Against Helminths: Schistosoma

Owen, Punt, Stranford. Kuby Immunology, 7th Edition

Immune Response Against Helminths

Delves, Martin, Burton, Roitt. Roitt’s Essential Immunology, 12th Edition.

Immune Evasion by Parasites

Abbas , Lichtman, Pillai. Cellular and Molecular Immunology, 7th Edition.

Immune Evasion by Protozoa: Trypanosome

Kenneth Murphy. Janeway's Immunobiology, Eighth Edition.

Bystander Chronic Infections

Erietta Stelekati, E. John Wherry. Chronic Bystander Infections and Immunity to Unrelated Antigens. Cell Host&Microbe, Volume 12, Issue 4, 18 October 2012, Pages 458–469

Thank you!