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Hazelo Lab Pvt. Ltd. Environmental Impact Assessment Report 6-1 Team Labs and Consultants 6.0 RISK ASSESSMENT AND DAMAGE CONTROL 6.0 Introduction This chapter presents the risk assessment study results for the plant operations, transport and storage of raw materials, and identifies maximum credible accident scenarios to draw the emergency management plan addressing various credible scenarios identified. 6.1. Objectives and Scope The production of Synthetic Organic chemicals (bulk drug and intermediates) involves usage of many chemicals which are both hazardous and toxic in nature. The risks associated with the chemical industry are commensurate with their rapid growth and development. Apart from their utility, chemicals have their own inherent properties and hazards. Some of them can be flammable, explosive, toxic or corrosive etc. The whole lifecycle of a chemical should be considered when assessing its dangers and benefits. In order to ensure the health and safety of persons at or near the facilities, Govt. has approved some regulations. The regulation requires Employers to consult with employees in relation to: - Identification of major hazards and potential major accidents - Risk assessment - Adoption of control measures - Establishment and implementation of a safety management system - Development of the safety report The involvement of the employees in identification of hazards and control measures enhances their awareness of these issues and is critical to the achievement of safe operation in practice. In order to comply with regulatory authorities, M/s Hazelo Lab Pvt. Ltd., have entrusted Team Labs and Consultants, Hyderabad to review and prepare Hazard analysis and Risk assessment for their facility along with an approach to on-site emergency preparedness plan as required under the acts and rules. (Manual on emergency preparedness for chemical hazards, MOEF, New Delhi). In this endeavor, the methodology adopted is based on;
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Page 1: Hazelo Lab Pvt. Ltd. Environmental Impact Assessment Reporttspcb.cgg.gov.in/publichearings/Hazelo Lab Pvt. Ltd., Yadadri... · Hazelo Lab Pvt. Ltd. Environmental Impact Assessment

Hazelo Lab Pvt. Ltd. Environmental Impact Assessment Report

6-1 Team Labs and Consultants

6.0 RISK ASSESSMENT AND DAMAGE CONTROL 6.0 Introduction

This chapter presents the risk assessment study results for the plant operations, transport

and storage of raw materials, and identifies maximum credible accident scenarios to draw

the emergency management plan addressing various credible scenarios identified.

6.1. Objectives and Scope

The production of Synthetic Organic chemicals (bulk drug and intermediates) involves

usage of many chemicals which are both hazardous and toxic in nature. The risks

associated with the chemical industry are commensurate with their rapid growth and

development. Apart from their utility, chemicals have their own inherent properties and

hazards. Some of them can be flammable, explosive, toxic or corrosive etc. The whole

lifecycle of a chemical should be considered when assessing its dangers and benefits. In

order to ensure the health and safety of persons at or near the facilities, Govt. has

approved some regulations. The regulation requires Employers to consult with employees

in relation to:

- Identification of major hazards and potential major accidents - Risk assessment - Adoption of control measures - Establishment and implementation of a safety management system - Development of the safety report

The involvement of the employees in identification of hazards and control measures

enhances their awareness of these issues and is critical to the achievement of safe

operation in practice. In order to comply with regulatory authorities, M/s Hazelo Lab Pvt.

Ltd., have entrusted Team Labs and Consultants, Hyderabad to review and prepare

Hazard analysis and Risk assessment for their facility along with an approach to on-site

emergency preparedness plan as required under the acts and rules. (Manual on emergency

preparedness for chemical hazards, MOEF, New Delhi). In this endeavor, the

methodology adopted is based on;

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• visualizing various probable undesirable events which lead to major accidents

• detailed and systematic assessment of the risk associated with each of those

hazards, including the likelihood and consequences of each potential major accident

event; and

• identifying the technical and other control measures that are necessary to reduce

that risk to a level that is as low as reasonably practicable

The strategy to tackle such emergencies, in-depth planning and person(s) or positional

responsibilities of employees for implementation and coordination of timely and effective

response measures are described in onsite detail in Emergency Plan.

6.2 Project Details

The project site is located at Survey Number 240, 242, 243, 247, 248 and 249, Dothigudem

Village, Pochampally Mandal, Yadadri Bhuvanangiri District, Telangana. The site is

located at the intersection of 170 17’ 17” (N) latitude and 780 50’ 46” (E) longitude. The site

elevation above mean sea level (MSL) is 407 m. The site is surrounded by open land in

north, west and south directions and SVR Laboratries Pvt. Ltd., in east direction. The

nearest habitation form the site is Antammagudem located at a distance of 0.65 km in east

direction. The main approach road is Dothigudem – NH9 connecting road in west

direction. National Highway-9 is at a Distance of 2.8 Km in Southwest Direction to the

site. The nearest Town is Choutuppal at a distance of 5.6 km in southeast direction and

nearest airport is Shamshabad located at a distance of 44 km in southwest direction.

Chinna Musi River is passing from NW to NE at a Distance of 5.8 Km in NW direction to

the site. There are seven reserve forests in the study area; Lakkaram RF at a distance of

1.2 km in south direction, Chauttuppal RF at a distance of 4.8 km in northwest direction,

Malkapuram RF at a distance of 2.2 km in west direction, Hafeezpura RF at a distance of 7

km in southwest direction, Ailaupur RF at a distance of 6.7 km in southwest direction,

Meharnagar RF at a distance of 5.3 km in northwest direction and Jalalpur RF at a distance

of 6.7 km in northwest direction are in the impact area. There is no National Park, Wildlife

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6-3 Team Labs and Consultants

sanctuary, ecologically sensitive area, critically polluted area and interstate boundary

within the impact area of 10 km surrounding the site. Total land area after expansion is

33.485 acres. The manufacturing capacities of the proposed bulk drug and intermediates

after expansion and by-products are presented in Table 6.1 and Table 6.2 Chemical

inventory is presented in Table 6.3

Table 6.1 Proposed Manufacturing Capacity – After Expansion S.No Name of Product CAS No. Capacity

(TPD) 1 Amlodipine Besylate 88150-42-9 0.33 2 Bupropion HCl 34841-39-9 0.83 3 Clopidogrel Hydrogen Sulfate 113665-84-2 0.33 4 Desvelofloxin Succinate 386750-22-7 0.17 5 Divolproex Sodium 76584-70-8 0.57 6 Dulaxetine HCl 136434-34-9 0.17 7 Esomeprazole Mg Dihydrate 217087-09-7 0.33 8 Glimepiride 93479-97-1 0.17 9 Mesalamine 89-57-6 0.17 10 Metaprolol Succinate 37350-58-6 0.50 11 Pantoprazole Sodium Sesquihydrate 138786-67-1 0.50 12 Pragabalin 148553-50-8 0.50 13 Rosuvastatin Calcium 287714-41-4 0.10 14 Sertraline HCl 79559-97-0 0.33 15 Tramadal 27203-92-5 0.67 16 Valcyclovir Hydrochloride Monohydrate 124832-27-5 0.33 17 4-[4-Chloro-1-oxobutyl]-2,2- dimethyl phenyl acetic acid

methyl ester 154477-54-0 0.10

18 N2-(1-(S)-ethoxy carbonyl-3-phenyl propyl-N6-trifluoro acetyl-L-lysine

116169-90-5 0.17

19 2-[2-[3(S)-[3-[2-(7-Chloro-2-Quinolinyl)-ethenyl]phenyl]-3-hydroxypropyl]phenyl-2-propanol

142569-70-8 0.10

20 2,8-Diazo bicyclo Nonane 151213-42-2 0.17 21 2,3,4,5-Bis-O- (1- methylethylidene)-b-D-fructopyranose 20880-92-6 0.83 22 2- Acetyl Ethoxy acetyl methoxy ether 1.13 23 N,N-Carbonyl di imidazole 530-62-1 1.67 24 (2S,3S,5S)-2-Amino-3-Hydroxy-5-Tert-Butylcarbonyl Amino

1,6-diohenyl 183388-64-9 0.10

25 Trans-4-(4-chlorophenyl)-cyclohexane carboxylic acid 49708-81-8 0.10 26 Guanine 73-40-5 1.67 27 Poly allyl amine HCl 71550-12-4 0.50 28 Tert-butyl 2-((4R,6S)-6-((E)-2-(4-(4-flurophenyl)-6-isopropyl-

2-(N- methylmethane sulfonamido) Pyrimidin - 5-yl)vinyl)-2,2-dimethyl-1,3-dioxane-4-yl-) acetate

0.17

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29 5-Cyano phthalide 82104-74-3 0.67 30 1,1-Cyclohexanediacetic acid 07-11-4335 1.67 31 Carbamyl Methyl-5-Methyl hexanoic Acid 181289-15-6 0.50 32 2',3'-Di-O-acetyl-5'-deoxy-5-fluorocytidine 161599-46-8 0.13 33 N-(2-Methyl-5-aminophenyl)-4-(3-pyridyl)-2-pyrimidine

amine 0.33

34 4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride

0.33

35 2, 3-Epoxy-2-methyl-N-[4-cyano-3-(trifluoromethyl) phenyl] propanamide

0.17

Worst Case : 20 products on Campaign basis 14.20

Table 6.2 List of By-Products – After Expansion S.No Name of Product Stage Name of By-Product Quantity

Kg/day TPM 1 Clopidogrel hydrogen sulfate I p-toluene sulfonic acid 180.8 5.4 2 1,1-Carbonyl diimidazole I Trichloromethanol 2782.5 83.5

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Table 6.3 List of Raw Materials and Inventory (Terms of Reference No. 3(iv) & (3(v)) S.No Name of Raw Material Max Storage

Quantity (Kgs)

Physical Appearance

Type of Hazard

Mode of Storage

1 (2-Methyl-5-nitrophenyl)guanidine. 1850 Liquid Irritant Drums 2 (2-Thienyl)ethyl para-toulene sulphonate 1700 Solid Corrosive Bags 3 (E)-3-(dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one 1700 Solid Irritant Bags 4 (R)-7-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-

[methyl(methylsulfonyl) amino]-5-pyrimidinyl]-5-pyrimidinyl]-3-hydroxy-5-oxo-6-heptenoic acid methyl ester

575 Liquid Irritant Drums

5 (S)-6-(2,2,2-trifluoroacetamido-2-amino hexanoicacid 1800 Liquid Corrosive Drums 6 (S)-N-Methyl-N-phenyl oxycarbonyl-3-(1-napthyloxy)-3-(2-

thienyl)propylamine 1225 Solid Flammable Bags

7 [[4-(4-Fluorophenyl)-6-(1-methylethyl)2-[methyl(methylsulfonyl) amino]-5-pyrimidinyl]methyl] triphenyl phoshonium bromide

1565 Solid Toxic Bags

8 1,3-Dicyclohexyl carbodiimide 500 Solid Irritant Bags 9 1,3-Dioxolane 3250 Liquid Flammable Drums

10 1-[2-Amino-1-(4-benzyloxyphenyl) ethyl] cyclohexanol 950 Liquid Toxic Bags 11 1H Imidazole 5000 Solid corrosive Bags 12 2-(Acetylamino)-1,9-dihydro-9-[[2-(acetyloxy)ethoxy]

methyl]-6H-purin-6-one 2470 Solid Combustible Bags

13 2,2,2-Trifluoroethylacetate 1555 Liquid Flammable Drums 14 2,2’-Azobis-(2-methyl propanamide) 50 Liquid Iritant Drums 15 2,2-Dipropylmalonic acid 3895 Liquid Iritant Drums 16 2,3-Pyridine Dicarboxylicacid 1545 Solid Irritant Bags 17 2,5,6-Triamino-3H-pyrimidin-4-one 5000 Solid Corrosive Bags 18 2-[(N,N-Dimethylamino)methyl] cyclohexanone 2310 Solid Corrosive Bags 19 2-Chloromethyl-oxirane 815 Liquid Toxic Drums 20 2-Cyanoacetamide 2785 Solid Flammable Bags 21 2-methyl cyano acetate 8000 Liquid Toxic Drums 22 2-methyl-2-phenyl propan-1-ol 615 Liquid Flammable Drums 23 2-Methylacrylic acid 465 Liquid Flammable Drums 24 3-(Carbamoylmethyl)-5-methylhexanoic acid 4090 Solid Corrosive Bags 25 3-[2-(7-chloro-2-quinolinyl)ethenyl]-alpha-[2-

(methoxycarbonyl-phenyl)methyl] -beta-oxo-730 Liquid Irritant Drums

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benzenepropanoicacid methyl ester 26 4-(2-Methoxy-ethyl)-phenol 1340 Liquid Corrosive Drums 27 4-(3,4-Dichlorophenyl)-3,4-dihydro-N-methyl-1(2H)-

Naphthalenimine 1900 Liquid Irritant Drums

28 4-[2-(3-ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido)ethyl]benzene sulfonamide

730 Solid Toxic Bags

29 4-Amino-2-(trifluoromethyl) benzonitrile 900 Liquid Flammable Drums 30 4-chloro butyryl chloride 450 Liquid Toxic Drums 31 4-Cyanobenzyl bromide 1485 Solid Corrosive Bags 32 5-(Difluoromethoxy)-2-[[3,4-dimethoxy-2-pyridinyl)

methyl]thio]-1H-benzimidazole 2295 Solid Toxic Bags

33 5-Carboxy Phthalide 8180 Solid Corrosive Bags 34 5-Fluorocytosine 300 Powder non-Hazard Bags 35 Acetic acid 3925 Liquid Flammable Drums 36 Acetic anhydride 6000 Liquid Flammable Drums 37 Acetone 30000 Liquid Flammable Storage Tanks 38 Acetonitrile 2080 Liquid Flammable Drums 39 Acetyl chloride 525 Solid Corrosive Bags 40 Activated Carbon 1750 Solid Flammable Bags 41 Aluminium chloride 5025 Solid Corrosive Bags 42 Aluminium Trichloride 50 Solid Irritant Bags 43 Ammonia Gas 2500 Gas Flammable Cylinders 44 Ammonium chloride (30%) 1500 Solid Corrosive Bags 45 Ammonium sulphate 1250 Crystalline non-Hazard Bags 46 Aniline 650 Liquid Toxic Drums 47 Benzene sulfonic acid 625 Liquid Toxic Drums 48 Benzyl chloride 480 Liquid Flammable Drums 49 Benzyl magnesium chloride 300 Liquid Highly Flammable Drums 50 Benzylamine 990 Liquid Flammable Drums 51 bis(trichloromethyl) carbonate 5000 Solid Toxic Bags 52 Boc anhydride 400 Liquid Flmmable Drums 53 Bromine 2615 Liquid Corrosive Drums 54 Bromo(3-methoxyphenyl) magnesium 3100 Liquid Corrosive Drums 55 Calcium acetate 100 Solid Corrosive Bags 56 Camphour sulphonyl chloride 50 Solid Flammable Bags 57 Carbenzyloxy-L-Valine 2010 Crystalline Carcinogenic Bags

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58 Carbon 100 Solid Non-Hazard Bags 59 Celite 50 Liquid Flammable Drums 60 Cerium chloride 250 Solid Non Flammable Bags 61 Chloroform 8000 Liquid Carcinogenic Drums Tanks 62 Cyclohexanone 4950 Liquid Flammable Drums 63 D-(-)-Fructose 3230 Solid Irritant Bags 64 D-(-)-Mandelic acid 425 Powder Irritant Bags 65 Di isopropyl ether 8000 Liquid Flammable Drums 66 Dimethyl formamide 20000 Liquid Flammable Storage Tanks 67 Dimethyl sulfoxide (DMSO) 8000 Liquid Flammable Drums 68 Di isopropyl Amine 3500 Liquid Flammable Drums 69 Dipotassium hydrogen phosphate 300 Powder Combustible Bags 70 Dichloro methane 30000 Liquid Carcinogenic Storage Tanks 71 Diethanolamine 400 Solid Irritant Bags 72 Ethanol 30000 Liquid Flammable Storage Tanks 73 Ethyl Acetate 30000 Liquid Flammable Storage Tanks 74 Ethyl acetate. HCl 100 Liquid Flammable Drums 75 Ethylene Di Chloride 8000 Liquid Toxic Drums 76 Formaldehyde 590 Liquid Flammable Drums 77 Formic acid 2515 Liquid Flammable Drums 78 Hexa methyl disilazane 150 Liquid Flammable Drums 79 n-hexane 20000 Liquid Flammable Storage Tanks 80 Hydrochloric acid 8315 Liquid Corrosive Drums 81 Hydrogen Cloride 500 Gas Flammable Cylinders 82 Hydrogen 250 Gas Flammable Cylinders 83 Hyflo super cel 400 Solid Non - Flammable Bags 84 Isopropanol 30000 Liquid Flammable Storage Tanks 85 Isopropyl amine 505 Liquid Flammable Drums 86 Isovalaraldehyde 1425 Liquid Flammable Drums 87 L-(-)-Camphor sulphonic acid 50 Solid Flammable Bags 88 Liq. Ammonia (20%) 300 Liquid Corrosive Drums 89 Lithium Hydroxide 200 Powder Toxic Bags 90 L-Lysine 1600 Solid Non-Hazard Bags 91 Magnesium chloride 440 Solid Non - Flammable Bags 92 m-chloroperbenzoic acid 750 Solid Irritant Bags 93 m-Chloropiophenone 3090 Solid Irritant Bags

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94 Methanol 30000 Liquid Flammable Storage Tanks 95 Methanolic HCl 200 Liquid Corrosive Drums 96 Methyl Isobutyl Ketone(MIBK) 7000 Liquid Flammable Drums 97 Methyl magnesium chloride 200 Liquid Flammable Drums 98 Methyl(+)-alpha-amino(2-chlorophenyl)acetate tartaric acid

salt 2110 Solid Irritant Bags

99 Methyl iodide 200 Liquid Toxic Drums 100 Mono Methyl amine (MMA) 3750 Liquid Flammable Drums 101 Monochlorobenzene 2780 Liquid Flammable Drums 102 N,N-Diisopropyl ethylamine 200 Liquid Flammable Drums 103 N,N-Dimethyl acetamide (DMA) 7500 Liquid Carcinogenic Drums 104 n-Butanol 20000 Liquid Flammable Storage Tanks 105 N-Methyl morphaline 350 Liquid Flammable Drums 106 N-Methyl piperazine 760 Liquid Corrosive Drums 107 N-methyl Pyrrolidone 2500 Liquid Carcinogenic Drums 108 n-Propanol 8500 Liquid Flammable Drums 109 Palladium carbon 675 Solid Irritant Bags 110 Para toluene sulphonyl chloride 660 Solid Flammable Bags 111 Phenyl alanine 300 Liquid Flammable Drums 112 Phenylethylamine 400 Liquid Toxic Drums 113 Phthalimido Amlodipine 2125 Solid Flammable Bags 114 Piperidine 50 Liquid Flammable Drums 115 Potassium bromide 50 Solid Irritant Bags 116 Potassium carbonate 685 Crystalline Irritant Bags 117 Potassium hydroxide 50 Solid Corrosive Bags 118 Potassium Permanganate 400 Crystalline Oxidizing Bags 119 Rany nickel 250 Solid Flammable Bags 120 Salicylic acid 950 Liquid Corrosive Drums 121 Sodium acetate 350 Solid Flammable Bags 122 Sodium amide 50 Solid Flammable Bags 123 Sodium bi carbonate 1325 Crystalline Irritant Bags 124 Sodium bisulphate 400 Solid Corrosive Bags 125 Sodium borohydride 1765 Powder Flammable Bags 126 Sodium carbonate 1315 Crystalline Irritant Bags 127 Sodium chloride 1100 Solid Corrosive Bags 128 Sodium Formate 7600 Granules Irritant Bags

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6-9 Team Labs and Consultants

129 Sodium Hydro sulfide 775 Crystalline Irritant Bags 130 Sodium hydroxide 15000 Liquid Corrosive Storage Tanks 131 Sodium hypochlorite 2775 Liquid Non - Flammable Drums 132 Sodium meta bisulfite 150 Powder Corrosive Bags 133 Sodium Nitrite 475 Solid Oxidizing Bags 134 Sodium sulphate 425 Granules Non-Hazard Bags 135 Sodium Sulphite 50 Granules Non-Hazard Bags 136 Sodium thiosulphate 950 Crystalline Non Flammable Bags 137 Sodiummeta bisulfite 1000 Powder Corrosive Bags 138 Stannic chloride 200 Crystalline Corrosive Bags 139 Succinic acid 750 Fine Crystals Corrosive Bags 140 Sulfuric acid 8000 Liquid Corrosive Drums 141 Tartaricacid 600 Crystalline Irritant Bags 142 Tert-Butyl-2((4R,6S)-6-(acetyloxy)methyl-2,2-dimethyl-1,3-

dioxan-4-yl) acetate 725 Liquid Solid Drums

143 Tert-butylamine 1335 Liquid Flammable Drums 144 Tetra butyl Ammonium Bromide 100 Solid Irritant Bags 145 Tetrahydrofuran 20000 Liquid Flammable Storage Tanks 146 Thionyl Chloride 6000 Liquid Toxic Drums 147 Toluene 30000 Liquid Flammable Storage Tanks 148 Trans-4-methylcyclohexyl isocyanate 300 Solid Toxic Bags 149 Tri butyl amine 5000 Liquid Irritant Drums 150 Tri ethylamine (TEA) 1750 Liquid Flammable Drums 151 Tri methyl chlorosilane 50 Liquid Flammable Drums 152 Urea 1000 Solid Irritant Bags

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6.3 Process Description

The manufacturing process for all the products is presented in Chapter 2. (Page No. 2-3 to

2-99) of the report.

6.4 Plant Facilities

The manufacturing facility shall be provided with

1) Production blocks 2) Utilities 3) Quality Control, R&D lab 4) Effluent and Sewage treatment plant 5) Warehouses

6) Tank farm area 7) Cylinder Storage 8) Administrative Office 9) Solvent recovery area

The production facilities shall be designed for proper handling of materials and machines.

Safety of operators, batch repeatability and process parameter monitoring shall be the

major points of focus in the design of facility. The current Good Manufacturing Practices

(GMP) guidelines shall be incorporated as applicable to synthetic organic chemicals

manufacturing facilities.

6.4.1 Production Blocks:

The Production blocks will consist of SS and glass lined reactors, storage tanks, shell &

tube heat exchangers, evaporators, vacuum pumps, packed columns, Agitated Nutche

Filter and Dryers, crystallizers, layer separators etc. The area shall be provided with

proper concealed drainage facility and all process facilities shall be performed under

protective environment.

6.4.2 Utilities:

It is proposed to establish coal fired boilers of capacity of 2 10 TPH in addition to existing 1

x 2 TPH coal fired boiler. The required steam for process and ZLD system shall be drawn

from proposed 2 x 10 TPH boilers. The DG sets required for emergency power during load

shut down is estimated at 2250 KVA and accordingly 2 x 1000 Kva DG sets are proposed

for expansion in addition to existing 1 x 250 Kva. The list of utilities is presented in the

following Table 6.4.

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Table 6.4 List of Utilities S.No Utility Permitted Proposed After Expansion

1 Coal Fired Boilers (TPH) 1 x 2 2 x 10

2 x 10 1 x 2

2 Thermic Fluid Heater (K.Cal) 1 Lac --- 1 Lac 3 DG Sets (kVA)* 1 x 250 2 x 1000 2 x 1000

1 x 250 *DG sets will be used during load shut down by TSPDCL.

6.4.3 Quality Control, R&D Lab

The QC department shall comprise of an in-process lab with instruments like HPLC, GC

etc. It will be maintained by highly qualified and trained people. The activities include:

• In-process quality check during manufacturing • Validation of facilities • Complaint handling

Also a process development laboratory shall be provided for in-house process

development, initial evaluation of process technology in case of technology transfer, back-

up for production department to address any issues arising during commercial production

6.4.4 ETP and Solid waste storage

The total effluents segregated into two streams High COD/ TDS and Low COD/ TDS

streams based on source of generation. These effluents are treated in Zero Liquid

Discharge system and the treated effluents are reused for cooling towers make-up and

scrubbers.

6.4.5 Ware Houses:

The plant shall have sufficient storage facility for safe handling of raw materials. All solid

raw materials shall be stored in marked areas with proper identification. Liquid raw

materials and solvents like which are available in drums will be stored according to

material compatibilities and flammability. Adequate fire fighting facilities shall be

provided as per NFPA norms.

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6-12 Team Labs and Consultants

6.4.6 Tank Farm Area:

A separate tank farm area shall be provided for storing liquid raw materials, especially

solvents with high inventory and also for toxic, corrosive chemicals. Dykes shall be

provided to ensure safety in case of tank failure. Acid proof lining for the dykes shall be

provided for acid storage tanks. Condensers for low volatile solvent storage tanks vents.

6.4.7 Cylinders storage Area:

Gas cylinders storage should conform to SMPV-Unfired rules-1981. Hydrogen cylinders

should be stored in approved Gas Storage pad. Chained and capped when not in use.

Operational cylinder should be firmly secured. Pressure regulator, metal piping, non-

return valve, and safe residue bleed off arrangement should be incorporated in installation

design. Strict hot work control and display of danger signs should be ensured.

6.4.8 Administrative Office:

An Administrative office shall be provided at the entrance of the factory to ensure the

entry of authorized personnel only into the premises.

6.4.9 Water Sump:

Water sump of 200 Kl capacity shall be provided for fire fighting in case of emergencies.

6.4.10 House Keeping:

A regular house keeping schedule with adequate preventive maintenance shall be ensured

so that the plant is consistently maintained as per GMP standards.

6.4.11 Facility layout and design:

The layout of all the various areas required for the facility, as mentioned above is

considered. In laying out the above areas, isolation of the various process areas from the

utilities and non-process areas is considered in view of both containment and cGMP. A

tentative plant layout is shown in Fig 6.1.

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Fig 6.1 Plant Layout of Hazelo Lab Pvt. Ltd.

S CALE 1Cm = 00 m trs

P RO D U CTIO N BLO CK40.0x12.5

PR OP O SED B LO CK40.0x19.0

40.0x12.5

8.0X 12.5MR O AD 5.0 M

D CPR OP O SED

14.0X 12.5MTA N K S

R O A D 5.0 M

R OA D 7.0 M

S O LV EN T YA RD45.3x60.0

LRM -II

40.0x20.0

U N LO A D IN G

P RO P O SE D B LO CK40.0x19.0

INT ER M E DIAT E STO RA G E

Q C& Q A

P RO PO SED

70.0x19.0

P RO PO SED S ERV ICE BLO CK70.0x12.5

R OA D 5.0 M

40.0x20.0

28.0x20.0

40.0x20.0

70.0x20.0

R O AD 5.0 M

40.0x 20.0

40.0x20.0

70.0x20.0

R O A D 5.0 M 25 .0x12.5B O ILER20.0x12.5

C O A L SHED

P RO P O SED B LO CKP RO PO SE D B LOC K

W A REH O U SE-I

L RM -I

50.0x20.0

40.0x20.0

W A R EH O U SE-II

C A N TEEN &C H A N G E RO O M S

P RO PO SED B LO CK

P RO PO SE D PILO T PLA N T

10.0x10.0

TEM PLE

FU TU R E

FU TU R E

FUT U RE

ZLD System

FU TU RE FU TU RE

FU TU R EFUT U RE

FU TU R E

STO R M W A TERPO N D

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6.5 Hazard Analysis and Risk Assessment

6.5.1 Introduction.

Hazard analysis involves the identification and quantification of the various hazards

(unsafe conditions) that exist in the plant. On the other hand, risk analysis deals with the

identification and quantification of risks, the plant equipment and personnel are exposed

to, due to accidents resulting from the hazards present in the plant.

Hazard and risk analysis involves very extensive studies, and requires a very detailed

design and engineering information. The various hazard analysis techniques that may be

applied are hazard and operability studies, fault-tree analysis, event-tree analysis and

failure and effects mode analysis.

Risk analysis follows an extensive hazard analysis. It involves the identification and

assessment of risks; the neighboring populations are exposed to as a result of hazards

present. This requires a thorough knowledge of failure probability, credible accident

scenario, vulnerability of population's etc. Much of this information is difficult to get or

generate. Consequently, the risk analysis is often confined to maximum credible accident

studies.

In the sections below, the identification of various hazards, probable risks, maximum

credible accident analysis, consequence analysis are addressed which gives a broad

identification of risks involved in the plant.

6.5.2 Hazard Identification (Terms of Reference No. 3(ix))

The Hazard identification process must identify hazards that could cause a potential major

accident for the full range of operational modes, including normal operations, start-up,

and shutdown, and also potential upset, emergency or abnormal conditions. Employers

should also reassess their Hazard identification process whenever a significant change in

operations has occurred or a new substance has been introduced. They should also

consider incidents, which have occurred elsewhere at similar facilities including within the

same industry and in other industries.

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Hazard identification and risk assessment involves a critical sequence of information

gathering and the application of a decision-making process. These assist in discovering

what could possibly cause a major accident (hazard identification), how likely it is that a

major accident would occur and the potential consequences (risk assessment) and what

options there are for preventing and mitigating a major accident (control measures). These

activities should also assist in improving operations and productivity and reduce the

occurrence of incidents and near misses.

The chemical and process industries have been using a variety of hazard identification

techniques for many years, ranging from simple screening checklists to highly structured

Hazard and Operability (HAZOP) analysis. Each technique has its own strengths and

weaknesses for identifying hazards. It is impossible to compare hazard identification

techniques and come to any conclusion as to which is the best. Each technique has been

developed for a specific range of circumstances taking many factors into account including

the resources required to undertake the analysis, expertise available and stage of the

process. While HAZOP is primarily a tool for hazard identification, the HAZOP process

can also include assessment of the causes of accidents, their likelihood and the

consequences that may arise, so as to decide if the risk is acceptable, unacceptable or

requires further study.. Moreover, a formal guidance for applying this technique is

available. Collaboration between management and staff is fundamental to achieving

effective and efficient hazard identification and risk assessment processes.

After identifying hazards through a qualitative process, quantification of potential

consequences of identified hazards using simulation modeling is undertaken. Estimation

of probability of an unexpected event and its consequences form the basis of quantification

of risk in terms of damage to property, environment or personnel. Therefore, the type,

quantity, location and conditions of release of a toxic or flammable substance have to be

identified in order to estimate its damaging effects, the area involved, and the possible

precautionary measures required to be taken.

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Considering operating modes of the facility, and based on available resources the following

hazard identification process chosen are:

a) Fire Explosion and Toxicity Index (FETI) Approach; b) HAZOP studies; c) Maximum Credible Accident and Consequence Analysis (MCACA); d) Classification of Major Hazard Substances; e) Manufacture Storage and Import of Hazardous Chemical Rules, 1989 (GOI Rules,

1989); f) Identification of Major Hazardous Units.

The physical properties of solvents used in the process are presented in Table 6.2 which

forms the basis for identification of hazards during storage and interpretation of the

Manufacture, Storage and Import of Hazardous Chemical Rules, 1989 (GOI Rules, 1989)

The interpretation of “The Manufacture Storage and Import of Hazardous chemicals”

issued by the Ministry of Environment and Forests, GOI, which guides the preparation of

various reports necessary for safe handling and storage of chemicals shows that the

present project requires preparation of safety reports before commencing operation and

risk assessment is not mandatory. The applicability of various rules is presented in Table

6.4.

Table 6.5 Applicability of GOI Rules to Storage/Pipeline S. No

Chemical Inventory KL

Threshold Quantity (T) For Application of Rules Applicable Rules 5,7-9, 13-15 10-12

1 Acetone 30 1500 10000 4 (1) (a), (2), 5,15 2 Dichloromethane 30 1500 10000 4 (1) (a), (2), 5,15 3 Ethanol 30 1500 10000 4 (1) (a), (2), 5,15 4 Ethyl Acetate 30 1500 10000 4 (1) (a), (2), 5,15 5 Isopropanol 30 1500 10000 4 (1) (a), (2), 5,15 6 Methanol 30 1500 10000 4 (1) (a), (2), 5,15 7 Toluene 30 1500 10000 4 (1) (a), (2), 5,15 8 Dimethyl formamide 20 1500 10000 4 (1) (a), (2), 5,15 9 n-hexane 20 1500 10000 4 (1) (a), (2), 5,15

10 n-Butanol 20 1500 10000 4 (1) (a), (2), 5,15 11 Tetrahydrofuran 20 1500 10000 4 (1) (a), (2), 5,15

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Table 6.6 Physical Properties of Raw Materials and Solvents S.No Name of Solvent TLV

(ppm) Toxicity Level Flammable Limit Chemical Class

(As per MSIHC Rules)

LD50 LD50 LC 50 (mg/1) Oral

(mg/kg) Dermal (mg/kg)

LEL (%)

UEL (%)

FP (OC)

BP (OC)

Class (As per Petroleum

Classification 1 Acetic acid 10 3310 1060 88 4 19.9 39 118 C Flammable 2 Acetone 1000 5800 20000 5540 2.6 13 <-20 56.2 B Flammable 3 Acetonitrile 40 3800 988 1000 3 17 2 81.6 B Flammable 4 Chloroform 50 60.5 Toxic 5 Di isopropyl ether 250 8470 14480 162000 1.0 21.0 .-28 67 C Flammable 6 Dichloromethane 50 670 2800 2270 6 11.4 13 40 B Carcinogenic 7 Dimethyl Formamide 10 2.8 1.5 9 2 15.2 58 153 B Flammable 8 Dimethyl sulfoxide 50 14500 5000 40250 1.8 63 95 189 B Non-Hazard 9 Ethanol 1000 1720 1025 20000 2.1 11.5 .-4 77 B Flammable 10 Ethyl acetate 400 5620 18000 2500 2.1 11.5 .-4 77 B Flammable 11 Ethylene Dichloride 10 670 2800 1000 6.0 11.4 13 84 A Flammable 12 Hexane 50 28710 2000 >20 1 8.1 .-22 69 B Flammable 13 Isopropyl alcohol 400 5045 12800 100000 2 12.7 12 82.4 B Flammable 14 Methanol 200 5628 15800 64000 5.5 36.5 11 64.5 A Flammbale 15 N,N Dimethyl

Acetamide 10 5.68 2.24 2475 1.8 11.5 69.5 166 B Carcinogenic

16 Tetrahydrofuran 200 1650 2000 2160 1.5 12.4 .-21.5 66 B Flammable 17 Toluene 200 636 12124 313 1.2 8 4 110.6 B Flammable 18 Methyl Iso Butyl

Ketone 100 2080 16000 8.2 1.2 8.0 14 117 B Flammable

19 Monochlorobenzene 75 1110 2200 10 1.3 7.1 29.44 132 B Flammable 20 n-Butanol 100 2733 2000 --- 2.3 8.0 14 83 B Flammable 21 N-Methyl-2-

Pyrrolidine 540 3914 7000 8000 1.3 9.2 91 202 B Flammable

22 Triethyl Amine 5 730 580 7.1 1.2 9.3 .-11 90 B Flammable

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6.5.3 Fire & Explosion Index (F & EI):

6.5.3.1 Methodology

Dow Chemical Company issued a guideline for hazard determination and protection. By

this method a chemical process unit is rated numerically for hazards. The numerical

value used is the Fire and Explosion Index (F&EI) which is most widely used for hazard

evaluation in chemical process industries.

The guide applies to process unit only and not to auxiliary units such as power

generating stations, plant water systems, control rooms, fired heaters, structural

requirements, corrosive nature of material handled and personal safety equipment. These

are regarded as basic features that do not vary according to the magnitude of the fire and

explosion hazard involved. The guide also does not cover the processing and handling of

explosives such as dynamite, TNT etc.

Computation of F&EI

The F&EI is calculated as a product of Material factor, General process hazard factor, and

special process hazard factor The Material factor is a measure of the intrinsic rate of

potential energy release from fire or explosion of most hazardous material or mixture of

materials present in significant quantity, whether it is raw material, intermediate,

product, solvent etc, by combustion or chemical reaction. “In significant quantity” here

means such quantity that the hazard represented by the material actually exists. The

National Fire Protection Agency of USA (NFPA) have specified standard values for

material factor which should be used for F&EI calculations and are available in Dow’s

Hazard Classification Guide. In case it is not readily available, it can be calculated using

the heat of combustion, flammability indices etc.

General process hazards are factors that play a primary role in determining the

magnitude of loss of incident. It takes into account the nature of the reaction, ventilation

of the unit, accessibility of the unit, drainage facilities etc., Special process hazards are

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factors that contribute primarily to the probability of a loss of incident. They consist of

specific process conditions that have shown themselves to be major causes of fire and

explosion incidents. It takes into account toxicity of the material, operating pressure,

operation near flammable range, quantity of material, joints and packing, use of hot oil

exchange system etc., The F&EI index is calculated as a product of Material factor,

General process hazard factor, and Special process hazard factor.

Hazard Ranking

The hazard ranking based on F&EI value is presented in Table 6.6.

Table 6.7 Degree of Hazard for F&EI F&EI Index Range Degree of Hazard

1 – 60 Light 61 – 96 Moderate

97 – 127 Intermediate 128 – 158 Heavy

159 & above Severe The estimated values of F&EI and hazard ranking are given in the Table 6.7. The radius

of exposure is determined by 0.26 meter x respective F&EI. The estimated values of F&EI

reflect light hazard in view of the low volume of chemicals.

The fire and explosion index evaluation can be very useful in developing plant layouts or

adding equipment and buildings to existing plants. Evaluation of the F&EI calculations

and layout considerations will result a safe, operable, maintainable and cost-effective

arrangement of equipment and buildings.

Table 6.8 Fire & Explosion Index for Tank farm S. No. Name of Solvent Fire &

Explosion Index (F1*F2*MF)

Radius of Exposure (m)

F&EIx0.26

Degree of Hazard

1 Acetone 76.78 19.96 Moderate 2 Dichloromethane 93.62 24.34 Moderate3 Ethanol 69.26 18.01 Moderate4 Ethyl Acetate 75.28 19.57 Moderate5 Isopropanol 77.35 20.11 Moderate6 Methanol 74.17 19.28 Moderate7 Toluene 86.82 22.57 Moderate8 Dimethyl formamide 55.18 14.35 Light

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9 n-hexane 77.16 20.06 Moderate10 n-Butanol 20.42 5.31 Light 11 Tetrahydrofuran 67.93 17.66 Moderate

F& E index value is found to be moderate except for Ethylene Dichloride (intermediate)

reflecting the threshold limits as prescribed in MSHC rules. Both MSHC rules and F & E

index indicate that the present facility does not require a detailed risk assessment.

6.5.4 Hazard and Operability Study (HAZOP)

Hazard and Operability Study (HAZOP) is a highly structured and detailed technique,

developed primarily for application to chemical process systems. A HAZOP can generate

a comprehensive understanding of the possible ‘deviations from design intent’ that may

occur. However, HAZOP is less suitable for identification of hazards not related to

process operations, such as mechanical integrity failures, procedural errors, or external

events. HAZOP also tends to identify hazards specific to the section being assessed, while

hazards related to the interactions between different sections may not be identified.

However, this technique helps to identify hazards in a process plant and the operability

problems. It is performed once the engineering line diagrams of the plant are made

available. It is carried out during or immediately after the design stage. The purpose of

the study is to identify all possible deviations from the way the design/operation is

expected to work and all the hazards associated with these deviations. A multi-

disciplinary team was constituted with chemical, mechanical and instrumentation

engineers, R&D chemist and production manager. It is important to keep the team small

enough to be efficient, while retaining a sufficient spread of skills and disciplines for all

aspects of the study to be covered comprehensively. The group discussion is facilitated

by a Chairman and the results of the discussion are recorded by a Secretary. Every

investigation must be led by Chairman who is familiar with the HAZOP study technique,

which is primarily concerned with applying, controlling the discussions and stimulating

team thinking.

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The preparative work for HAZOP studies consisted of four stages i.e., obtaining the data,

converting into usable form, planning the sequence of the study and arranging the

necessary meetings. The documents referred to for the study include process description,

process flow diagrams, P&I diagrams plant layout, operating manuals including startup

& shutdown, safety instructions etc., The parameters such as temperature, pressure, flow,

level were investigated for deviation and hazard situations are identified.

Some basic definitions of terms frequently used in HAZOP studies are deviation, causes,

consequences and guide words etc., Deviations are departures from the design intent

which are discovered by systematically applying the guide words. Causes are the reasons

why deviations might occur. Consequences are the reasons why deviations should they

occur. Guide words are simple words used to understand a particular plant section in

operating condition in order to guide and simulate the creative thinking process and so

discover deviations. NO, less, more, as well as, part of, reverse, other than are guide

words used.

Potential problems as represented by the consequences of the deviation should be

evaluated as they arise and a decision reached on whether they merit further

consideration or action. Except for major risk areas where a fully quantitative assessment

is required this decision is made semi-quantitatively on the consequence (usually scaled

as trivial, important or very probable).

6.5.5 Hazard Factors

A study of past accident information provides an understanding of failure modes and

mechanisms of process and control equipment and human systems and their likely effects

on the overall plant reliability and safety. Some of the major contributing factors for

accidents in chemical industries are:

S. No Contributing Factor Percent Loss 1 Equipment design faults 41 2 Process design faults 10 3 Operator errors 31

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4 Maintenance deficiencies 12 5 Material hazards 6

A study by AIChE (1972) indicates that majority of equipment of component failures

involve compressors, furnaces and heat exchangers as there are lesser opportunities to

take them off for maintenance. The frequency of equipment or component failures is

observed as follows:

S. No Equipment Frequency (%)

1 Compressors 30 2 Furnaces 18 3 Heat Exchangers 17 4 Process Vessels 18 5 Others 17

However, failures of storage vessels and those during transportation have been reported

more frequently than cases of plant failures. The failure rate of various equipment in a

typical power plant is provided in the following table.

Equipment Failure Rates Failure rate Failures 10-6/h Electric motors (general) 10 Transformers (<15 kV) 0.6 (132-400k V) 0.7 Circuit breakers (general, <33k V) 2 (400kV) 10 Pressure vessels (general) 3 (High standard) 0.3 Pipes 0.2 Pipe joints 0.5 Ducts 1 Gaskets 0.5 Bellows 5 Diagrams (metal) 5 (Rubber) 8 Unions and junctions 0.4 Hoses (heavily stressed) 40 (Lightly stressed) 4

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Failure rate Failures 10-6/h Ball bearings (heavy duty) 20 (Light duty) 10 Roll bearings 5 Sleeve bearings 5 Shafts (heavily stressed) 0.2 (Lightly stressed) 0.02 Relief valves leakage 2 Blockage 0.5 Hand- operated valves 15 Control valves 30 Ball valves 0.5 Solenoid valves 30 Rotating seals 7 Sliding seals 3 ‘O’ring seals 0.2 Couplings 5 Belt drives 40 Spur gears 10 Helical gears 1 Friction clutches 3 Magnetic clutches 6 Fixed orifices 1 Variable orifices 5 Nozzle and flapper assemblies: Blockage 6 Breakage 0.2 Filters: blockage 1 Leakage 1 Rack-and-pinion assembles 2 Knife-edge fulcrum: wear 10 Springs (heavily stressed) 1 (Lightly stressed) 0.2 Hair springs 1 Calibration springs: creep 2 Breakage 0.2 Vibration mounts 9 Mechanical joints 0.2 Grub screws 0.5 Pins 15

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Failure rate Failures 10-6/h Pivots 1 Nuts 0.02 Bolts 0.02 Boilers (all types) 1.1 Boilers feed pumps 2.5 Cranes 7.8

6.5.6 Common Causes of Accidents

Engineering and Instrumental

Based on the analysis of past accident information, common causes of major chemical

plant accidents are identified as:

• Poor house keeping • Improper use of tools, equipment, facilities • Unsafe or defective equipment facilities • Lack of proper procedures • Improving unsafe procedures • Failure to follow prescribed procedures • Jobs not understood • Lack of awareness of hazards involved • Lack of proper tools, equipment, facilities • Lack of guides and safety devices • Lack of protective equipment and clothing

Failures of Human Systems

An assessment of past chemical accidents reveals human factor to be the cause for over

60% of the accidents while the rest are due to other plant component failures. This

percentage will increase if major accidents alone are considered for analysis. Major

causes of human failures reported are due to:

• Stress induced by poor equipment design, unfavorable environmental conditions, fatigue, etc.

• Lack of training in safety and loss prevention. • Indecision in critical situations. • Inexperienced staff being employed in hazardous situations.

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Often, human errors are not analyzed while accident reporting and accident reports only

provide information about equipment or component failures. Hence, a great deal of

uncertainty surrounds analysis of failure of human systems and consequent damages.

The number of persons/materials are potentially exposed to a specific hazard zone is a function of the population density and distribution near the accident location. The failure rate data and ignition sources of major fires are presented in the following Tables 6.8 and 6.9.

Table 6.9 Failure Rate Data

S.No Item International Data 1. Process Controllers 2.4 x 10-5 hr-5 2. Process control valve 2.0 x 10-6 hr-1 3. Alarm 2.3 x 10-5 hr-1 4. Leakage at biggest storage tank 5.0 x 10-5 yr-1 5. Leakage of pipe line 1 x 10-7 m-1 yr-1 6. Human Failure 1 x 10-4 (demand)-1

Table 6.10 Ignition Sources of Major Fires S.No Ignition Source Percent 1. Electrical (wiring of motors) 23% 2. Smoking 18% 3. Friction 10% 4. Over heated material 8% 5. Burner flames 7% 6. Combustion sparks 5% 7. Spontaneous ignition 4% 8. Cutting & welding 4% 9. Exposure (fires jumping into new areas) 3% 10. Incendiarism (fires maliciously set) 2% 11. Mechanical sparks 2% 12. Molten substances 1% 13. Chemical actions 1% 14. Static sparks 1% 15. Lightening 1% 16. Miscellaneous 1%

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6.6 Maximum Credible Accident and Consequence Analysis (MCACA)

The potential hazards due to toxic and inflammable nature of the raw materials, process

streams and products can be quantified. However, it is necessary to carry out a hazard

analysis study to visualize the consequences of an unexpected release from chemical

plant, which consists of a number of process units and tank farm facilities. The present

study provides quantified picture of the potential hazards and their consequences

6.6.1 Methodology

MCACA aims at identifying the unwanted hazardous events, which can cause maximum

damage to plant and personnel. At the first instance, all probable accident scenarios are

developed. Scenarios are generated based on properties of chemicals, physical conditions

under which reactions occur or raw materials stored, as well as material strength of

vessels and conduits, in-built valves and safety arrangements, etc. Creating a scenario

does not mean that it will occur, only that there is a reasonable probability that it could. A

scenario is neither a specific situation nor a specific event, but a description of a typical

situation that covers a set of possible events or situations.

This is the basis of the risk study; it tells us what may happen so that ways and means of

preventing or minimizing the possibility can be devised. The next step is estimation of

the probability of each accident scenario. A credible accident is one within the realm of

possibility and is likely to be severe enough to cause significant damage. This concept

comprises of two parameters- probable damage caused by an accident and probability of

occurrence of an accident .There may be types of accidents that may occur frequently, but

would cause very little damage. And there may be other types that may cause great

damage, but would have a very low probability of occurrence. Both are important and

need to be considered, even if they are later discarded. A host of probable accident

scenarios are visualized examined and credibility of probable events is established based

on engineering judgment, past accident data and expertise in the field of risk analysis.

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The following steps are involved in identifying the maximum credible accident scenarios.

a. A detailed study of the process and plant information including process flow diagrams

and piping & instrumentation diagrams.

b. Hazard classification of chemicals, operations and equipment.

c. Identification of representative failure cases of vessels and pipelines and the resulting

release scenarios

d. Establishment of credibility of visualized scenarios based on past accident data.

6.6.2 Identification of Vulnerable Areas

The unit operations in the process and storage areas involve mass and energy transfer

operations to effect the necessary physical changes. Nature of chemicals and the

operating conditions create special hazardous situations. In the present case the chemicals

handled are flammable and toxic in nature. With these factors in mind a thorough

examination of the process information is carried out and a list of inventories of the

hazardous chemicals is prepared to identify the hazardous situations. Based on the raw

material consumptions determined from the pilot scale studies, experience in handling

commercial scale processes and logistics in procurement of raw materials, the inventories

to be maintained for each of the raw material and its mode of storage is determined. High

inventory liquid raw materials like solvents are usually stored in tank farms, while solids

and other low inventory liquids are stored in ware house based on compatibility,

reactivity, toxicity etc. with appropriate safety and fire fighting facilities to handle any

kind of emergencies. The solvent tank farm and the capacity of each tank is mentioned

in table 6.4.

6.6.3 Representative Accident Scenarios

A study of past accidents, which took place in similar process units and the present plant,

provides reasons and course of accidents and there by focusing on most critical areas. A

thorough examination of engineering details indicated many possible scenarios like

gasket leak, pinholes in pipes and vessels apart from rupture of pipelines and vessels

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and catastrophic failure of vessels resulting in a pool. Heat radiation damage distances

for Pool fire was considered.

Failure Frequency:

The release scenarios considered above can be broadly divided in to two categories

(i) Catastrophic failures which are of low frequency and

(ii) Ruptures and leaks which are of relatively high frequency

Vapor or liquid release from failure of gasket, seal and rupture in pipe lines and vessels

fall in second category whereas catastrophic failure of vessels and full bore rupture of

pipe lines etc., fall in to first category. Typical failure frequencies are given in Table 6.10.

Table 6.11 General Failure Frequencies Item Mode of failure Failure frequencies Pressure Vessel

Serious leak 1.0*10-5/Year Catastrophic 3.0*10-6/Year

Pipe lines =50 mm dia

Full bore rupture 8.8*10-7/m.year Significant leak 8.8*10-6/m.year

>50 mm =150 mm dia

Full bore rupture 2.6*10-7/m.year Significant leak 5.3*10-6/m.year

>150 mm dia

Full bore rupture 8.8*10-8/m.year Significant leak 2.6*10-6/m.year

hose Rapture/Failure 4.0*10-5/hr Unloading arm Rapture/Failure 3.0*10-8/hr Check valve Failure on demand 1.0*10-4/on demand motor operated valve Failure on demand 1.0*10-3/ on demand Flange Leak 3.0*10-4/ Year Pump seal Leak 5.0*10-3/ Year Gasket failure Failure 5.0*10-5/ Year Process safety valve(PSV)

Lifts heavily 4.0*10-3/ Year Blocked 1.0*10-3/ Year Lifts lightly 6.0*10-2/ Year

6.7 Consequence Analysis

The accidental release of hazardous chemicals leads to subsequent events, which actually

cause the damage. The damages are of three types.

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1) Damage due to heat radiation.

2) Damage due to Over pressure effects subsequent to explosion

3) Damage due to toxic effects

The type of damage and extent of damage depends on nature of chemical, the conditions

of release, atmospheric conditions and the subsequent events. The sequence of probable

events following the release of a hazardous chemical is schematically shown in Figure

6.2. The best way of understanding and quantifying the physical effects of any accidental

release of chemicals from their normal containment is by means of mathematical

modeling. This is achieved by describing the physical situations by mathematical

equations for idealized conditions and by making corrections for deviation of the

practical situations from ideal conditions. In the present study ALOHA software from

USEPA. These models for various steps are described in the following sub-sections.

6.7.1 Release Models and Source strength

This depends on the nature of failure of the unit and the content of the unit and operating

temperature and pressure of the unit. The release may be instantaneous due to total

failure of storage unit or continuous due to leakage or rupture of some component of the

storage facility. The material discharged may be gas or liquid or the discharge could be

manifested through two phase flow. The models that are used to calculate the quantity of

liquid/vapor released are:

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Fig 6.2 Steps in Consequence Calculations

The following criteria tables present heat radiation intensities (Table 6.11), radiation

exposure and lethality (Table 6.12), and damage due to peak over pressure is presented

in Table 6.13.

Table 6.12 Damage Due to Incident Radiation Intensities S. No Incident

Radiation (KW/m2)

Type of Damage Intensity Damage to Equipment Damage to the People

1 37.5 Damage to process Equipment 100% lethality in 1 min.

1% lethality in 10 sec.

2 25.0 Minimum energy required to ignite wood at indefinitely long exposure without a flame

50 % lethality in 1min.

Significant injury in 10 sec.

3 19.0 Maximum thermal radiation intensity allowed n thermally unprotected adjoining equipment.

---

4 12.5 Minimum energy to ignite with a flame, melts plastic tubing

1% lethality in 1 min.

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5 4.0 -- Causes pain if duration is longer than 20 sec, however blistering is unlikely ( First degree burns)

6 1.6 -- Causes no discomfort on Longer exposure

Source: Techniques for Assessing Industrial Hazards by World Bank

Table 6.13 Radiation exposure and lethality

Radiation Intensity (KW/m2)

Exposure Time (seconds)

1% Lethality Degree Burns

1.6 -- 0 No Discomfort even after longer exposure

4.5 20 0 1st 4.5 50 0 1 st 8.0 20 0 1 st 8.0 50 <1 3 rd 8.0 60 <1 3 rd

12.0 20 <1 2 nd 12.0 50 8 3 rd 12.5 -- 1 -- 25.0 -- 50 -- 37.5 -- 100 --

Table 6.14 Damage Due to Peak Over Pressure Human Injury Structural Damage

Peak Over Pressure (bar)

Type of Damage Peak over Pressure (bar)

Type of Damage

5 – 8 100% lethality 0.3 Heavy (90%Damage) 3.5 – 5 50% lethality 0.1 Repairable (10%Damage) 2 – 3 Threshold lethality 0.03 Damage of Glass

1.33 – 2 Severe Lung damage 0.01 Crack of Windows 1 – 11/3 50% Eardrum rupture - -

Source : Marshall, V.C.(1977)’ How lethal are explosives and toxic escapes. 6.7.2 Results of Consequence Analysis

The damages due to the accidental release of chemicals are of three types. a) Damage due to heat radiation b) Damage due to Over pressure effects subsequent to explosion c) Damage due to Toxic effects

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6.7.2.1 Analysis of Hazardous Scenarios

The hazardous chemicals involved are stored within the threshold limits of storage and

hence few representative chemicals mainly solvents were studied.

6.7.2.1.1 Heat radiation effects (Terms of Reference No. Sp. TOR (13))

When a non-boiling liquid spills, it spreads into a pool. The size of the pool depends on

the availability of the bund and obstacles. The heat load on objects outside a burning pool

of liquid is calculated with the heat radiation model. The average heat radiation intensity,

the diameter-to-height ratio dependent on the burning liquid, geometric view, distance

from the fire, relative humidity of air, horizontal or vertical orientation of the object

radiated with respect to fire are factored. All storage tanks in tank-farm area are provided

with dykes. For each of the hazardous chemicals involved various scenarios such as pipe

line leaks of 5mm or pipeline ruptures or catastrophic vessel ruptures of the inventories

as outlined have been considered and damage distances for Lower Flammability Limits

(LFL) and heat radiation effects for the three levels of intensity are calculated and

presented in Table 6.14 . Heat radiation damage distances for most of the scenarios are

not occurring in the case of release from 25 mm holes at a height of 0.1 m from the bottom

of the tank for one hour, in the storage tanks. In case of pipeline leaks, 5 mm leaks are

considered for 15 mm and 50 mm pipe sizes. The release rates from 5 mm leaks are

observed to be low, and these leaks have low incident hazard. The concentration of the

flammable material in the vapor cloud was found to be below the lower flammability

limits. Heat radiation damage distance (Pool Fire) is presented in Fig 6.3 to Fig 6.5.

Table 6.15 Heat Radiation Damage Distances – Tank Farm

S.No Name of Raw material

Tank Capacity

(KL)

Diameter (m)

Height (m)

Hole Dia

(mm)

Release Rate

(Kg/sec)

Heat radiation damage distances in m for

KW/m2 37.5 12.5 4.0

1 Acetone 30 3.1 4.0 25 0.38 <10 <10 <10 2 Dichloromethane 30 3.1 4.0 25 2.07 <10 <10 12 3 Ethanol 30 3.1 4.0 25 0.38 <10 <10 <10 4 Ethyl acetate 30 3.1 4.0 25 0.40 <10 <10 <10 5 n-hexane 20 2.6 3.7 25 0.34 <10 <10 11

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6 Isopropyl alcohol

30 3.1 4.0 25 0.38 <10 <10 <10

7 n-Butanol 20 2.6 3.7 25 0.38 <10 <10 <10 8 Methanol 30 3.1 4.0 25 0.38 <10 <10 <10 9 Tetrahydro furan 20 2.6 3.7 25 0.40 <10 <10 <10 10 Dimethyl

formamide 20 2.6 3.7 25 0.42 <10 <10 <10

11 Toulene 30 3.1 4.0 25 0.40 <10 <10 11

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Fig 6.3 Heat Radiation Damage - 30Kl Dichloromethane Tank

S C A LE 1C m = 00 m trs

P R O D U CT IO N BL O CK40.0x12.5

P RO PO SE D BLO CK40.0x19.0

40.0x12 .5

8 .0X 12 .5MR O A D 5 .0 M

D CP RO PO SED

1 4.0X 12.5MT A N K S

R O A D 5 .0 M

R O A D 7 .0 M

S O LV EN T Y A RD4 5.3x60.0

L RM -II

40.0x20.0

U N LO A D IN G

P RO PO SE D B LO CK40.0x19.0

IN TER M E D IA TE S TO RA G E

Q C & Q A

PR O PO SED

70.0x19 .0

P RO PO SED S ERV IC E BL O CK70.0x12.5

R O A D 5 .0 M

40.0x20.028.0x20.0 40.0x20.0

70.0x20.0

R O A D 5 .0 M

40.0x20 .0

40 .0x20.0

70.0x 20.0

R O A D 5 .0 M 25.0x1 2.5B O ILER20.0x 12.5

C O A L SH ED

P RO PO SE D B LO CKP RO PO S ED BLO C K

W A RE H O U SE-I

L RM -I

50.0x20.0

40.0x20.0

W A R E H O U SE-II

C A N TE EN &C H A N G E RO O M S

P RO PO SE D BL O CK

P RO P O SE D P IL O T PLA N T

10.0x10.0

T EM PLE

FU T U R E

F U T U R E

FU T U R E

Z L D S ystem

F U T U R E F U T U R E

F U T U R EFU T U R E

FU T U R E

S T O R M W A T E RPO N D

D C M

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Fig 6.4 Heat Radiation Damage - 30Kl Toluene Tank

S C A L E 1 C m = 00 m trs

P R O D U C T IO N B L O C K4 0.0x 12 .5

P R O P O S E D B L O C K4 0.0x 19 .0

4 0.0x 12 .5

8 .0 X 12 .5MR O A D 5.0 M

D CP R O P O SE D

1 4 .0 X 12.5MT A N K S

R O A D 5 .0 M

R O A D 7 .0 M

S O L V E N T Y A R D4 5.3x 60 .0

L R M -II

4 0.0x 20 .0

U N L O A D IN G

P R O P O S E D B L O C K4 0 .0x 19 .0

IN T E R M E D IA T E ST O R A G E

Q C & Q A

P R O P O SED

7 0.0x 19 .0

P R O P O SE D S E R V IC E B L O C K7 0 .0x 12 .5

R O A D 5 .0 M

4 0 .0x 20 .028 .0x 20 .0 4 0 .0x 20 .0

7 0 .0x 20 .0

R O A D 5 .0 M

4 0 .0x 20 .0

40 .0x 20 .0

7 0.0x 20 .0

R O A D 5 .0 M 2 5 .0x 12 .5B O ILE R2 0 .0x 12 .5

C O A L SH E D

P R O P O S E D B L O C KP R O P O S E D B L O C K

W A R E H O U SE-I

L R M -I

50 .0x 20 .0

4 0.0x 20 .0

W A R E H O U SE -II

C A N T E EN &C H A N G E R O O M S

P R O P O S E D B LO C K

P R O P O S E D P ILO T PL A N T

1 0.0x 10 .0

T E M PL E

F U T U R E

F U T U R E

F U T U R E

Z L D S ys tem

F U T U R E F U T U R E

F U T U R EF U T U R E

F U T U R E

S T O R M W A T E RP O N DT olue ne

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Fig 6.5 Heat Radiation Damage - 20Kl n-hexane Tank

S C A LE 1 C m = 0 0 m trs

P R O D U C T IO N B LO C K40 .0x12.5

P R O P O S E D B L O C K40 .0x19.0

4 0.0x12 .5

8 .0X 12 .5MR O A D 5 .0 M

D CP R O P O S ED

1 4 .0X 12 .5MT A N K S

R O A D 5 .0 M

R O A D 7 .0 M

S O L V E N T Y A R D4 5 .3x60 .0

L R M -II

40 .0x20.0

U N L O A D IN G

P R O P O S E D B LO C K4 0.0x19 .0

IN T E R M ED IA T E S T O R A G E

Q C & Q A

P R O PO S E D

70 .0x19.0

P R O PO SE D S E R V IC E B LO C K7 0.0x12 .5

R O A D 5.0 M

4 0.0x20 .02 8 .0x20 .0 4 0 .0x20 .0

7 0.0x20 .0

R O A D 5.0 M

4 0 .0x20 .0

4 0.0x20 .0

7 0.0x20 .0

R O A D 5 .0 M 2 5 .0x12 .5B O IL ER20 .0x12.5

C O A L S H E D

P R O P O S E D B LO C KP R O P O S E D B L O C K

W A R E H O U S E-I

L R M -I

5 0.0x20 .0

4 0 .0x20 .0

W A R E H O U S E -II

C A N T E E N &C H A N G E R O O M S

P R O P O S E D B LO C K

P R O P O S E D P IL O T PLA N T

10 .0x10.0

T E M PLE

F U T U R E

F U T U R E

F U T U R E

Z L D S ystem

F U T U R E F U T U R E

F U T U R EF U T U R E

F U T U R E

S T O R M W A T E RP O N D

n -h ex ane

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Table 6.16 Heat Radiation Damage Distance – Hydrogen Cylinders S.

No. Scenario Description

Release Rate

Kg/sec

Storage Tank Details Heat radiation damage distances in m for KW/m2

Height (m)

Dia (m)

Storage Pressure

37.5 12.5 4.0

1 Hydrogen Gas Cylinder (50Kg)

5.42 0.87 0.27 350 Bar <10 12 20

6.7.2.1.2 Toxic Dispersion:

Whenever there is an accident release of volatile toxic material into atmosphere, it gets

dispersed into atmospheric air. The concentration of the material in space with respect to

time is determined using appropriate dispersion models. Toxic models are employed to

assess the consequences to human health as a result of exposure to toxic gases.

When IDLH (Immediate Danger to Life and Health) are used in conjunction with air

dispersion modeling, the resulting analysis can help evaluate the potential consequences

of any toxic chemical release from point of view of public health and welfare.

A material may be considered as toxic or poisonous, when a small quantity can cause

injurious effect on an average normal adult human being. There are several ways of

expressing the severity of toxic nature of the chemicals. These are;

TLV – Threshold Limit Value The maximum concentration limit for a normal eight-hour workday and 40 hours per

week to which nearly all workers may be repeatedly exposed day after day with out any

effects on health.

LDlo - Lethal dose low The lowest concentration of a chemical at which some test animals die following

inhalation exposure.

IDLH- Immediate Danger to Life and Health The maximum concentration limit to which a healthy worker can be exposed for 30

minutes and escape without suffering irreversible health effects or escape impairing

symptoms.

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LD50 – Median lethal dose The dose at which 50 percent of test animals die following exposure. Dose is usually

expressed as milligrams for kilogram of body weight of test animal. The most popular

way of expressing lethality of toxic loads is to use probit functions.

P = A + B ln (Cn t) where P is probit value, A , B, n – constants specific to the chemical t -- time of exposure in seconds, c – concentration in mg /m 3 or ppm

Knowing the concentration level and time of exposure, the percentage lethality may be

estimated. However for most of the chemicals the characteristic constants are not available

and in such cases IDLH values are used.

The storage of toxic chemicals was evaluated with respect to failure of containment

resulting in toxic dispersion and the toxic damage distances were calculated using

ALOHA software. The results of the same are presented in Table 6.16. Toxic Dispersion

damage distances are shown in Fig 6.6 to 6.7

Table 6.17 Toxic Dispersion Damage Distance S.No Name of Raw

material Diameter

(m) Height

(m) Storage Pressure

Release Rate

(Kg/sec)

IDLH (ppm)

Distance (m)

1 Ammonia (50Kg) 0.87 0.27 7.86 Bar 0.004 300 17 2 Hydrogen Chloride

(1000Kg) 0.30 0.65 42.26 Bar 0.066 50 117

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Fig 6.6 Toxic Dispersion of Ammonia Cylinder

Fig 6.7 Toxic Dispersion of 1Ton HCl Cylinder.

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6.7.2.1.3 Overpressure effects:

When an unignited gas cloud mixes with air and reaches the flammable range and if the

cloud ignites wither a flash fire or flash fire explosion can occur. Since the burning time is

shorter, instead of heat radiation from a flash fire, peak overpressure as a function of

distance from the centre of the cloud is derived. In case of pipeline leaks, damage

distances due to overpressure effects are not observed. The values are found to be similar

as there are no pressurized storage tanks in the tank farm, and the over pressure

distances are contingent on the tank capacity.

6.7.3 Observations:

From the previous incident records published in literature and hydrocarbon release data

bases, it has been observed that pinhole leaks contribute highest percentage where as the

second cause is small sized leaks of 25 mm diameter in tank farm. Accordingly the

consequence analysis was carried out for 25 mm sized leaks in the tank farm.

6.7.4 Recommendations:

The following are the recommendations to minimize the hazards and improve the safety

of the proposed plants. Plants of this nature, which handle a variety of chemicals, face

problems of fire and vapor cloud explosions. It has been observed that for the proposed

plants the damage distances are more or less confined to the plant area only. Taking

precautionary safety measures as outlined below can further minimize these effects.

• In view of hazardous nature of operations, it is recommended to adopt best practices

with respect to design, operation and maintenance.

• It is recommended that all flammable areas and process area be maintained free of

ignition sources. Ensure that sources of ignition, such as pilot lights, electrical

ignition devices etc., at strategic locations like solvent storage areas are avoided.

• All electrical fittings involved in and around the pipeline and operation system

should conform to flame/explosion proof regulations.

• Strict hot work control and display of danger signs should be ensured.

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• It is recommended to provide one fire hydrant point in the tank-farm area to take

care of any emergency. Installation of fire water hydrant net work is suggested.

• It is suggested to provide fire extinguishers in process plant at solvent storage area

and the vents of solvent tanks to be provided with PESO approved flame arrestors.

• Fire protection equipment should be well maintained so that it is available when

required. They should be located for quick accessibility. Provide carbon dioxide fire

extinguishers and DCP extinguishers for Electrical fires.

• It is suggested to have a periodical review of safety awareness and safety training

requirements of plant employees with respect to hazards present in the plant.

• In general, all pipelines carrying flammable liquids/vapor are periodically checked

for their integrity. Spillages have to be avoided and disposal should be done

quickly.

6.7.5 Toxic Management Plan (Terms of Reference No. Sp. TOR (14))

The list of chemicals identified to have toxic or carcinogenic nature is presented in Table

6.17.

Table 6.18 List of Toxic/Carcinogenic Chemicals and Mode of Storage/Transport S.No Name of Raw Material Max

Storage Quantity

(Kgs)

Physical Appearance

Type of Hazard

Mode of Storage

1 [[4-(4-Fluorophenyl)-6-(1-methylethyl)2-[methyl(methylsulfonyl) amino]-5-pyrimidinyl]methyl] triphenyl phoshonium bromide

1565 Solid Toxic Bags

2 1-[2-Amino-1-(4-benzyloxyphenyl) ethyl] cyclohexanol

950 Liquid Toxic Bags

3 2-Chloromethyl-oxirane 815 Liquid Toxic Drums 4 2-methyl cyano acetate 8000 Liquid Toxic Drums 5 4-[2-(3-ethyl-4-methyl-2-oxo-3-

pyrroline-1-carboxamido)ethyl]benzene sulfonamide

730 Solid Toxic Bags

6 4-chloro butyryl chloride 450 Liquid Toxic Drums 7 5-(Difluoromethoxy)-2-[[3,4-

dimethoxy-2-pyridinyl) methyl]thio]-1H-benzimidazole

2295 Solid Toxic Bags

8 Aniline 650 Liquid Toxic Drums 9 Benzene sulfonic acid 625 Liquid Toxic Drums

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10 bis(trichloromethyl) carbonate 5000 Solid Toxic Bags 11 Carbenzyloxy-L-Valine 2010 Crystalline Carcinogenic Bags 12 Chloroform 25000 Liquid Carcinogenic Storage

Tanks 13 Dichloro methane 30000 Liquid Carcinogenic Storage

Tanks 14 Ethylene Di Chloride 8000 Liquid Toxic Drums 15 Lithium Hydroxide 200 Powder Toxic Bags 16 Methyl iodide 200 Liquid Toxic Drums 17 N,N-Dimethyl acetamide (DMA) 7500 Liquid Carcinogenic Drums 18 N-methyl Pyrrolidone 2500 Liquid Carcinogenic Drums 19 Phenylethylamine 400 Liquid Toxic Drums 20 Thionyl Chloride 6000 Liquid Toxic Drums 21 Trans-4-methylcyclohexyl isocyanate 300 Solid Toxic Bags

Handling: Storage & handling in compliance with MSDS. The transfer of solvents shall be

mainly by closed pipeline systems, while solvents are transferred from drums by using

air operated diaphragm pumps in closed hoods. Solid phase raw materials are charged

by using closed hoppers to avoid dust emissions and hazard of static electricity. SOP’s

for better operational control.

Engineering Control Measures: All the operations filtration, centrifugation, drying is

conducted in closed conditions. Forced dry ventilation system to hoods. Vent condensers

in series to reactors, distillation columns, driers and centrifuge to mitigate atmospheric

emissions of toxics. Solvents with low boiling point will be stored in double limpet coil

storage tanks with coolant circulation.

Vents of secondary condensers connected to vacuum pumps followed by tertiary

condenser. Common headers connecting all the process vents and the same are connected

to scrubbers. Low boiling solvents tanks are connected with reflux condensers to

minimise the loss. The transfer pumps shall be provided with mechanical seals.

Personnel Protective Equipment: Personal protective equipment shall be provided to all

employees including contract employees. All the employees shall be provided with

gumshoe, helmet, masks, goggles. The other equipment like ear muffs, gloves, respirators,

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aprons etc., will be provided to employees depending on the work area allocated to them.

The PPE selection shall strictly follow the prescribed guidelines of MSDS.

Health Monitoring of Employees: The pre employment screening and periodic medical

examination shall follow the guidelines of factories act. The pre employment screening

shall obtain medical history, occupational history followed by physical examination and

baseline monitoring for specific exposures.

Pre employment check up will be made mandatory and following test will be conducted:

• Plan of evaluation of health of workers

Chest x rays ECG Haemogram (examination of the blood) Urine (Routine and Microscopic) Complete physical examination

- Musculo-skeletal disorders (MSD) - Backache - Pain in minor and major joints - Fatigue, etc.

Frequency of Health Monitoring Occupation Type of evaluation Frequency Process area Complete blood count, platelet count, and

measurement of kidney and liver function, and medical examination with focus on liver, kidney, nervous system and skin,

Every 5 years to age <30; every 4 years to age 31 – 40; and every 2 years to age 41-50; Once a year above 50 years.

6.7.6 Transportation (Terms of Reference No. 7(iii)

All the raw materials and finished products are transported by road. Dedicated parking

facility is provided for transport vehicles. The plant is located in an industrial area, and

there will not be any unauthorized shop or settlements along the road connecting the

plant site. There will be 10-12 truck trips per day to the factory. Safety signage is placed

at various locations in the battery limit. The drivers of the vehicles will be provided with

TREM cards and will be explained the measure to be adopted during various

emergencies.

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Transportation of raw materials may result in accidents due to high speed collision, low

speed collision, overturning and non-accident-initiated release. The initiating and

contributing causes are presented in Table 6.18

Table 6.19 Truck Incidents – Initiating and Contributing Causes Human Errors Equipment Failures System or Procedural

Failures External Events

Driver Impairment

Non-dedicated trailer Driver incentives Vandalism/ Sabotage

Speeding RR crossing guard Driver training Rain Driver Overtired Failure Carrier selection Fog Contamination Leaking Valve Container Specification Wing Overfilling Leaking Fitting Route selection Flood/washout Other Vehicle's Driver

Brake Failure Emergency response training

Fire at rest areas/parking areas

Taking Tight Insulation/Thermal Protection Failure

Speed Enforcement Earthquake

Unsecured Load Relief device failure Driver rest periods Existing accident Tire failure Maintenance Inspection Soft shoulder Overpressure Time of day Restrictions Material defect Steering failure Sloshing High center of gravity Corrosion; Bad Weld; Excessive Grade Poor Intersection design Suspension system

The scenarios presented for storages are calculated for transport related

incidents/accidents and presented in Table 6.19.

Table 6.20 Transportation Specific Concerns Concern Road Spill on Water Over or near a body of water Unconfined Pools In an undisturbed flat area BELVE-Induced catastrophic vessel failure

Possible if sufficient quantity in car with small leak to feed fire or if double tank trailer or burning fuel leak

Toxic products of combustion or reaction

Dependent on material and whether ignition occurs

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6.7.7 Control Measures for Accidental Spillage of Chemicals Name of the Chemical Stored

Storage Details Hazard Rating Systems Type of Hazards Involved Persons Effected

Control Measures Quantity

(KL) Pressure/

Temp TLV

(PPM) STEL (PPM)

FP (OC)

Acetone 30 NTP 1000 500 -20 Highly flammable liquid and vapor. Causes serious eye irritation. May cause drowsiness or dizziness.

Operators Maintenance Technicians

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Safety board’s displayed on the tank. Effective ventilation must be provided. For accidental contact if you feel unwell, seek medical advice immediately. Handling of Acetone with Safety gloves and protective clothing

Dimethyl Formamide

30 NTP 10 58 Flammable liquid and vapor Harmful in contact with skin Causes serious eye irritation Harmful if inhaled

Operators Maintenance Technicians

Avoid exposure - obtain special instructions before use. Avoid contact with skin and eyes. Avoid inhalation of vapor or mist. Keep away from sources of ignition - No smoking. Take measures to prevent the buildup of electrostatic charge. Wear respiratory protection. Avoid breathing vapors’, mist or gas. Ensure adequate ventilation.

Methanol 20 NTP 1000 1000 14 Highly flammable liquid and vapor.

Operators Maintenance Technicians

Keep away from heat/sparks/open flames/hot surfaces. Use personal protective

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equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas.

Dichloromethane 20 NTP 50 13 Limited evidence of a carcinogenic effect.

Operators Maintenance Technicians

Do not breathe gas/fumes/vapour/spray. Avoid contact with skin and eyes Wear suitable protective clothing and gloves. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage

Toluene 20 NTP 200 4 Highly flammable liquid and vapor. May be fatal if swallowed and enters airways. Causes skin irritation May cause drowsiness or dizziness. May cause damage to organs through prolonged or repeated exposure

Operators Maintenance Technicians

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. Use personal protective equipment as required. IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician. Do NOT induce vomiting. Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation

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6.8 Disaster Management Plan (Terms of Reference No. 7(xiii)

6.8.1 Introduction

A disaster is a catastrophic situation in which suddenly, people are plunged into

helplessness and suffering and, as a result, need protection, clothing, shelter, medical and

social care and other necessities of life.

Disasters can be divided into two main groups. In the first, are disasters resulting from

natural phenomena like earthquakes, volcanic eruptions, storm surges, cyclones, tropical

storms, floods, avalanches, landslides, and forest fires. The second group includes

disastrous events occasioned by man, or by man's impact upon the environment.

Examples are armed conflict, industrial accidents, radiation accidents, factory fires,

explosions and escape of toxic gases or chemical substances, river pollution, mining or

other structural collapses, air, sea, rail and road transport accidents and can reach

catastrophic dimensions in terms of human loss.

There can be no set criteria for assessing the gravity of a disaster in the abstract since this

depends to a large extent on the physical, economic and social environment in which it

occurs. However, all disasters bring in their wake similar consequences that call for

immediate action, whether at the local, national or international level, for the rescue and

relief of the victims. This includes the search for the dead and injured, medical and social

care, removal of the debris, the provision of temporary shelter for the homeless, food,

clothing and medical supplies, and the rapid re- establishment of essential services.

An emergency may be said to begin when operator at the plant or in charge of storage of

hazardous chemicals cannot cope up with a potentially hazardous incident, which may

turn into an emergency. The emergencies could be a major fire or explosion or release of

toxic gas or a combination of them.

The proposed plant will store fuels, which are flammable in nature, and the storage will be

as per the Controller of Explosives and OISD norms. The hierarchy of the employees is

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yet to be determined and the project is still in the initial stages of designing. Hence a

tentative disaster management plan is prepared to be suitably modified before

commissioning of the plant.

6.8.2 Objectives of Emergency Management Plan (ON-SITE) (Terms of Reference No. 7(xiii) A quick and effective response during emergency can have tremendous significance on

whether the situation is controlled with little loss or it turns into a major emergency

Therefore, the objectives of this Onsite Emergency Plan (ONSEP);

During Emergency: Is to provide basic guidance to the personnel for effectively combating

such situations to minimize loss of life, damage to property and loss of property.

• To localize the emergency and if possible eliminate it;

• To minimize the consequences of an emergency;

• To prevent spreading of the damage in other areas;

• To give necessary warning to plant personnel and neighborhood;

• To maximize resource utilization and combined efforts towards the emergency

operations;

• To mobilize internal resources and utilize them in the most effective way;

• To arrange rescue of persons, transport and treatment of causalities; • To seek necessary help from industries in neighborhood or local authorities;

• To provide information to government agencies and to provide information to

public.

During Normal Time:

• To keep the required emergency equipment in stock at right places and ensure their working condition;

• To keep the concerned personnel fully trained in the use of emergency equipment;

• Preserving records, evidence of situation for subsequent emergency etc.

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6.8.3 Scope of ONSEP

This ONSEP is prepared for industrial emergencies like fires, explosions, toxic releases,

asphyxia and does not cover natural calamities and societal disturbances related

emergencies (like strikes, bomb threats, civil Commissions etc). Also, the scope of this

ONSEP is limited to onsite emergencies and does not include measures for off site

Emergency Management. Necessary information with regards to Off Site Emergency

Management will be furnished to district authorities.

6.8.4 Methodology of Developing ONSEP

The consideration in preparing this Emergency Plan includes the following steps:

• Identification and assessment of hazards and risks;

• Identifying, appointment of personnel & Assignment of Responsibilities;

• Identification and equipping Emergency Control Center;

• Identification of Assembly, Rescue points, Medical Facilities;

• Formulation of plan and of emergency sources;

• Training, Rehearsal & Evaluation;

• Action on Site.

Earlier, a detailed Hazard Analysis and Risk Assessment were carried out for the plant

facilities and the hazards are quantified. The likely locations of hazards and consequences

are evaluated, duly following the standard procedure.

6.8.5 Elements of Onsite Emergency Plan

Important elements considered in this plan are:

• Identification of emergencies

• Emergency organization

• Emergency facilities

• Emergency procedures

• Communications during emergency

• Rescue, Transport and Rehabilitation

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• Roles and responsibilities of key personnel and essential employees

• Mutual aid.

6.8.5.1 Emergencies Identified

Spillage, pool fire, are the possible emergencies in the pipelines, fire near storage, DG

set, and Transformers are the other possible emergencies.

The other emergencies are asphyxiation of persons, apart from risks due to cyclonic

conditions, earth quake, lightning, floods (natural calamities), sabotage, bombing (social

and other reasons) etc. which are not under the management control.

Priority of protection in the event of an emergency is; Life and safety of personnel,

preservation of property, restoration of normalcy.

6.8.5.2 Emergency Organization

The project employs a total of 600 people in 3 shifts. The general shift will be for the

administrative employees, while the three shifts of 8 hours each are for technical

employees. Key personnel and essential employees are identified and are assigned

emergency responsibilities. The organogram of the essential organization are presented

below:

Security personnel, all operators, fitters, electricians etc. in the shifts are designated

essential employees. During emergencies, their services are drafted for essential

operations.

6.8.5.3 Emergency Facilities

a) Emergency Control Center (ECC)

It is a location where all key personnel like Chief Coordinator, Emergency controller,

maintenance coordinator can assemble and monitor aspects related to emergency and

take decisions related to emergency. The office room is designated as ECC. In case if this

area is affected, zone security room is designated as alternative ECC.

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The following information and facilities would be maintained at the ECC in Plant Control

room:

Latest copy of Onsite Emergency Plan and Offsite Emergency Plan (as provided by

District Emergency Authority)

• Intercom Telephone;

• P& T Telephone;

• Telephone directories (internal and P&T);

• Factory Layout, site plan;

• P&I diagrams, electrical connections plans indicating locations of hazardous

inventories, sources of safety equipment, hydrant layout, location of pump house,

road plan, assembly points, vulnerable zones, escape routes;

• Hazard chart;

• Emergency shutdown procedures for generators and fuel supply system;

• Nominal roll of employees;

• List and addresses of key personnel;

• List and addresses of emergency coordinators;

• List and addresses of first aid providers;

• List and addresses of employees trained in fire fighting;

• List and addresses of qualified trained persons;

• Material safety data sheets of raw materials;

• Duties of key personnel;

• Important addresses and telephone numbers including those of fuel supplying

company, government agencies, neighboring industries and other sources of help,

outs side experts;

The following emergency equipment is made available at alternate ECC (Security point):

• Fire proximity suit/Gloves/Helmets;

• Hand tools suitable for pipe lines (non sparking type);

• Gaskets;

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• Teflon tape;

• Gas Explosimeter;

• Flame proof torches/batteries;

• 1/2 crow bar;

• Spade;

• Manila rope;

• Spark arrestor;

• Spare fan belt for truck;

• First aid box;

• Special fire fighting information related to Hydrocarbon fuels;

• Public address megaphone, hand bell, Emergency torch.

b) Assembly points

Office room is identified as Assembly point and is in a low intensity fire affected zone.

Additionally the following places in plan are designated as safe assembly points: Time

office, and green belt area near the main road. The locations of assembly points would be

reviewed later.

c) Fire fighting Facilities

The fire fighting facilities which shall be provided are presented in Table 6.20.

Table 6.21 List of Fire Extinguishers S.No Description of Item Quantity

1. DCP 10 kg 80 Nos. 2. Foam 50 ltrs 50 Nos. 3. CO2 22.5 kg 30 Nos. 4. CO2 6.8 kg 25 Nos. 5. ABC Soda Acid 5 kg 40 Nos. 6. ABC Soda Acid 1 kg 40 Nos. 7. Fire Buckets with stand 50 Nos.

d) Location of First aid Boxes

The first aid boxes will be located at the following places: preparation areas,

administrative office, time office, and will be under the charge of security coordinator.

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e) Emergency siren

Emergency siren will be provided with 0.5 km range of audibility and the location will be

time office. The siren will operate on regular supply and also on emergency electrical

supply. Shift electrical engineer of plant on receipt of information from shift incharge, is

authorized to operate the siren.

f) Emergency escapes

Emergency escapes in the plant area and floor wise emergency escapes will be

conspicuously marked.

g) Wind sock

Wind socks to observe the wind directions will be installed on the top of Turbine Plant

house.

6.8.5.4 Emergency Procedures

a) Procedure for Raising Emergency alarm

Whenever and whoever notices an emergency or a situation with a potential emergency

should forthwith raise alarm by calling on the available communication network or

shouting or approaching the shift incharge, furnishing details. Any body noticing fire

should inform the plant control room immediately. The shift electrical engineer at

control room informs the site controller.

b) Control Room staff

If an emergency is reported then plant control room staff must, request for the location,

nature and severity of emergency and obtain the caller's name, telephone number, and

inform the shift incharge or site controller who ever are available in the shift.

c) Emergency communication

The following communications will be used during emergencies; P&T Telephones,

intercom, walkie-talkies, hand bell and siren. If any of the equipment is not working,

runners would be engaged to send the communication.

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d) Warning/Alarm Communication of emergency

Emergency siren would be operated to alert all other employees on the orders of manager

(electrical). The emergency is communicated by the Emergency siren mode of wailing for

3 minutes. When the emergency has been brought under control, the Emergency

controller will direct plant control staff giving an 'all clear signal', by way of normal siren

(continuously for 3 minutes).

6.8.5.5 Rescue and Rehabilitation

Emergency vehicle will be made available round the clock under the charge of manager

(electrical) who is emergency coordinator. Security personnel are trained in rescue

operations. Persons rescued would be taken to First aid centre for further medical

attention or Safe Assembly Points as per the condition of the rescued person.

a) Transport Vehicles and Material Trucks

The transport vehicles and vehicles with materials would immediately withdraw to

outside the factory. Security guard of the shift is responsible for this. Transport vehicles

would wait at the security at the main entrance to provide emergency transport. This is

ensured by security coordinator.

b) Mock drill

Occasional mock drill is essential to evaluate that the ONSEP is meeting the objectives.

Adequate training is given to all staff members before conducting the mock drill. Mock

drills will be initiated with table top exercise, followed by pre-informed mock drills, and

few uninformed mock drills in the first phase. Functional exercises (communication,

Emergency shut down, fire fighting at different locations, rescue etc.) are carried out in

the second phase.

Mock drills will familiarize the employees with the concept and procedures and help in

evaluating their performance. These scheduled and unscheduled mock drills are

conducted during shift change, public holidays, in night shift once in 6 months.

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Response time, strict adherence to discharge of responsibilities, difficulties and

inconsistencies experienced are recorded and evaluated. Fire officer will assists

Emergency coordinator in designing and extending such mock drills and in evaluating

the response.

c) Review

The Emergency plan is reviewed periodically to evaluate the effectiveness, and during

change in organizational structure, isolation of equipment for longer duration, and

during increase in inventory of fuel and other chemicals. Manger Electrical and

Emergency coordinator initiates and authorizes such review as and when required, and

the changes if any will be duly informed to all the employees concerned.

6.8.5.6 Emergency Responsibilities

I. Chief Coordinator

The chief coordinator shall be General manger and Alternate is Manager Electrical.

• He is overall incharge of emergency operations.

• He reaches emergency control center as soon as he receives emergency

information.

• He coordinates with emergency controller, maintenance coordinator.

• He provides necessary resources required at the emergency site.

• He will inform the inspector of factories, and other statutory authorities.

• Prepares accident report/investigation.

• Arranges for keeping records of chronological events and orders an

investigation report and preserves evidence.

• Gives a public statement if necessary.

II. Emergency controller - Shift in charge

On receiving the message about emergency;

• He will assume charge as chief coordinator till general manger arrives at

scene and takes charge as a chief coordinator.

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• Takes actions to minimize the consequences and directs emergency

management and fire control/other causes with available personnel to put

off or to reduce the consequences.

• On the arrival of chief coordinator, he will hand over the charge of Chief

coordinator and assists him.

• He will identify the need of evacuating any personnel in the vicinity of the

affected zone.

• Exercises operational control of the installation and outside the affected area

and directs emergency operations.

• Declares emergency and orders plant control room for operation of

emergency siren.

• Continuously reviews and assesses possible development to determine

most probable courses of events.

• Initiates suspension of all work permits during the period of major

emergency for safe guarding the plant and other personnel.

III. Incident Controller

The Supervisor assumes the role of incident controller in the following instances of

emergencies.

• Protects himself and proceeds to site quickly.

• Assess the magnitude of the incident.

• Initiates the emergency procedure to secure the safety of the workers and

minimise damage to installation and property.

• He will undertake all possible steps for safe isolation of plant systems, first

aid and fire fighting.

• He keeps in touch with plant control room till emergency controller arrives

at the scene of emergency,

• Organizes essential employees present in the shift.

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• Ensures that adequate personal protective equipment is available foe

essential employees.

• Arranges for search of causalities.

• Arranges evacuation of non-essential workers to assemble at designated

assembly points.

• During the fire fighting operations seeks help from electrical/mechanical

maintenance personnel for isolation of machine/section involved in fire as

the need arises.

• Once the situation is under control, guides different persons for salvage and

cleanup operations.

• Assists in assessing the loss, preparation of accident report with the

assistance of security officer and senior officials of respective departments

present during the accident, investigates the fire with a view to find out

causative factors ad action needed to prevent recurrence.

IV. Communicator – production supervisor

• The Control Room Shift Electrical Engineer assumes the role of

Communicator and passes the information related to emergency to Incident

Controller and Chief Coordinator.

• Other vulnerable installation in the plant is alerted about the emergency.

• On the Instructions from chief coordinator, neighboring installations are

alerted about the emergency.

• On the instructions from Chief Coordinator, mutual assistance is called

from neighboring industries.

• On the instructions from Chief Coordinator, seeks help form fire brigade.

• Provides emergency Telephone rosters are provided in Plant control room

and Fire Station.

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V. Maintenance Coordinator

Dy. Manager Mechanical shall assume the role of maintenance coordinator. His

responsibilities include;

• Protecting him self.

• Reaching the emergency spot.

• Arranging all resources for assisting Emergency controller to mitigate the

Emergency scene, with respect to maintenance requirements.

• Assisting Emergency controller in arranging the needed containment

measures.

• Undertaking post emergency maintenance work upon termination of

emergency.

• Ensuring availability of adequate quantities of protective equipment and

other emergency materials, spare parts etc at Emergency control center.

• Ensuring upkeep of fire systems, emergency lighting in order.

VI. Resource Coordinator

Shift in charge shall assume the responsibility of resource coordinator.

• Arranges first aid, rescue acts, ambulance, attendance roster checking and

security.

• Interacts with chief coordinator for all emergency operations.

• Assists chief coordinator with necessary data and coordinates the

emergency activities.

• Maintains liaison with civil administration and mutual aid agencies -

neighboring industrial management.

• Ensures availability of humanitarian needs and maintenance of

rehabilitation center.

• Ensures emergency transport facility.

• Mobilizes extra medical help from outside if necessary.

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• Maintains first aid and medical emergency requirements.

• Keeps list of qualified first aid providers and seeks their assistance.

• Ensures availability of necessary cash for rescue/rehabilitation and

emergency expenditure.

• Coordinates mutual aid.

• Participates in reviewing Emergency plan and arranges revision if required.

VII. Security Coordinator.

The production supervisor will assume the responsibilities of security coordinator, and

his responsibilities are;

• On receipt of fire call from plant control he prepares for fire fighting and

collects necessary equipment.

• Organizes rescue of persons trapped in work areas.

• Assists administration coordinator in organizing Mock drills, evaluation

and debriefing.

• During normal situations keeps the fire fighting capabilities in fully ready

condition by maintaining equipment.

• Organizes fire drills on periodic basis and evaluates the same.

• Arranges to clear off unconnected persons and trucks from the vicinity and

off the main gate.

• Instructs security guards posted on duty in the nearby industries to cordon

off the affected section and to control the crowd at the scene of fire.

• Arranges to control law and order till local authorities for Law and order till

police arrive at site.

• Post security guard at the scene of fire to check for possible re-ignition, after

the emergency is over.

• Assists Resource coordinator in organizing Mock Drills, evaluation and

debriefing.

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VIII. Person Noticing Fire

Any employee on noticing fire will take the following steps;

• Takes protection

• Raises alarm – shouts fire! Fire!! Fire!!! Or other emergency.

• Informs Shift Incharge, or at the control room over telephone giving clear

message about the exact location of fire and names of

equipment/machinery involved in fire.

• If Telephone is not working, quickly goes to either Plant Control Room and

informs.

IX. Trained Fire Fighting Person

The employees trained in fire fighting will take the following steps in the event of fire

apart from following the instructions of security coordinator apart from;

• Protects self

• Raises alarm

• Attempts to put out the fire using fire extinguishers.

• If necessary, operates fixed fire fighting equipment.

• Stands by in safety for further instructions.

6.8.6 Remedial Action

The cause of emergency is identified and action is taken from operation point of view

such as isolating or shutdown etc.

I. Failure of pipelines: feeding into the pipeline is stopped. Isolate the leaking

pipeline by closing the relevant valves. Transfer the material present to other

pipelines. Shutdown the pump. Close the suction and discharge valves of the

pump

II. Personal Protection: The people, who are assigned to the rescue operations,

must wear suitable personnel protective equipment such as self-contained

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breathing apparatus and fire suit. They should remain in the incident area as

long as he can safely stay there. In spite of the wearing safety protective

equipment if he is unable to stay in the contaminated area, he should leave

immediately.

6.8.7 BASIC ACTION IN EMERGENCIES

Immediate action is the most important factor in emergency control because the first few

seconds count, as fires develop and spread very quickly unless prompt and efficient

action is taken.

• Take immediate steps to stop leakage/fire and raise alarm simultaneously. • Initiate action as per fire organization plan or disaster management plan, based on

gravity of the emergency. • Stop all operations and ensure closure and isolation valves. • All effort must be made to contain leakage/fire. • Saving of human life shall get priority in comparison to stocks/assets. • Plant personnel with specific duties should assemble at the nominated place. • All vehicles except those required for emergency use should be moved away from

the operating area, in an orderly manner by the predetermined route. • Electrical system except for control supplies, utilities, lighting and fire fighting

system should be isolated. • If the feed to the fire cannot be cut off, the fire must be controlled and not

extinguished. • Start water spray system at areas involved or exposed to fire risks to avoid domino

effects. • In case of leakage of chemicals without fire and inability to stop the flow, take all

precautions to avoid source of ignition. • Block all roads in the adjacent area and enlist police support for the purpose if

warranted.

6.8.8 FIRE FIGHTING OPERATIONS

Enlist support of local fire brigade and neighboring industries.

• Fire fighting personnel working in or close to unignited vapor clouds or close to

fire must wear protective clothing and equipment including safety harness and

manned lifeline. They must be protected continuously by water sprays. Water

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6-62 Team Labs and Consultants

protection for fire fighters should never be shut off even though the flames appear

to have been extinguished until all personnel are safely out of the danger area.

• Exercise care to ensure that static charge is not generated in vapor cloud. For this

purpose solid jet of water must be avoided, instead fog nozzles must be used.

• Fire fighters should advance towards a fire in down wind direction.

• If the only valve that can be used to stop the leakage is surrounded by fire, it may

be possible to close it manually. The attempt should be directed by trained

persons only. The person attempting closure should be continuously protected by

means of water spraying (thorough fog nozzles), fire entry suit, water jet blanket

or any other approved equipment. The person must be equipped with a safety

harness and manned lifeline.

• Any rapid increase in pressure or noise level of should be treated as a warning of

over pressurization. In such case all personnel should be evacuated immediately.

• In case of any emergency situation, it is of paramount importance to avoid

endangering human life in the event of fire, involving or seriously exposing plant

equipment.

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HAZELO LAB PVT. LTD. SY.NO. 240, 242, 243, 247, 248 AND 249, DOTHIGUDEM VILLAGE, POCHAMPALLY MANDAL, YADRADI BHUVANAGIRI DISTRICT, 

TELANGANA   

        

2. ENVIRONMENT MANAGEMENT PLAN 

    

  

  

   

Project No. 0317‐21‐01March 2017 

 

Hazelo Lab Pvt. Ltd. Hetero Corporate Office, 7‐2‐A2, Industrial Estate Sanath Nagar, Hyderabad,  Telanagana – 500 018 Phone: 08455‐233585  Fax: 08455‐233840   E‐mail: [email protected] 

STUDIES AND DOCUMENTATION BYTEAM Labs and Consultants B‐115‐117 & 509, Annapurna Block, Aditya Enclave, Ameerpet,  Hyderabad‐500 038. Phone: 040‐23748 555/23748616, Telefax: 040‐23748666      

 

SUBMITTED TO TELANGANA STATE POLLUTION CONTROL BOARD,  

REGIONAL OFFICE, NALGONDA

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Hazelo Lab Pvt. Ltd., Contents

 

CONTENTS Page No. 1.0 Introduction 1-1 1.1 Environment Management Plan 1-2

1.1.1 Construction Phase 1-2 1.1.2 Operation Phase 1-3

2.0 Sources of Pollution from Manufacturing Process 1-3 2.1 Water Pollution 1-4

2.1.1 Process Description and Technical Specification of Effluent Treatment System 1-6 2.2 Air Pollution 1-13

2.2.1 Emissions from Utilities 1-13 2.2.2 Emissions from Process 1-14 2.2.3 Diffuse Emissions 1-18 2.2.4 Fugitive Emissions 1-18 2.2.5 Odor Management 1-18

2.3 Solvent Use and Recycle 1-19 2.4 Solid Waste 1-21 2.5 Noise Pollution 1-22 3.0 Rainwater Harvesting 1-23 4.0 Occupational Safety and Health 1-26 4.1 Medical Check-up 1-27 4.2 Handling of Toxic Chemicals/Materials 1-28 5.0 Prevention, maintenance and operation of Environment Control System 1-29 6.0 House Keeping 1-29 7.0 Socio Economic Environment 1-30 8.0 Transport systems 1-31 9.0 Reduce, Recovery and Reuse 1-32

10.0 Energy Conservation 1-32 11.0 Green Belt Development 1-32 12.0 Corporate Environmental Responsibility 1-35 13.0 Environment Management Cell 1-35 14.0 CREP Guidelines and Compliance 1-37 15.0 Other Management Practices 1-37 16.0 Cost Estimate for Environment Management Plan 1-38

 

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Hazelo Lab Pvt. Ltd., Contents

List of Tables 

List of Figures 

S.No Description Page. No. 1.1 Total Effluents Generated and Mode of Treatment 1-4 1.2 Process Effluents Quantity and Quality – Product Wise 1-5 1.3 Details of Treatment Facilities 1-7 1.4 Technical Specifications of Effluent Treatment System 1-9 1.5 Technical Specifications of Biological Treatment Plant 1-10 1.6 Emission Details of Pollutants from Stack 1-13 1.7 Technical Specifications of Bag Filters 1-14 1.8 Quantity and Mode of Treatment of Process Emissions 1-15 1.9 Technical Specifications of Two Stage Scrubber 1-17

1.10 Total Solvent Balance – Product Wise after expansion 1-19 1.11 Solid Waste and Mode of Disposal 1-22 1.12 Storm Water Management 1-24 1.13 Frequency of Health Monitoring 1-28 1.14 Corporate Social Responsibilities – Budget (2017-18 to 2021-22) 1-30 1.15 Activity Wise CSR – Budget (2017-18 to 2021-22) – Program 1-31 1.16 Environmental Management Cost estimate 1-38 1.17 Item Wise Tentative Capital Cost Estimate for Environment Management 1-38

S.No Description Page. No. 1.1 Schematic Diagram of Effluent Treatment System 1-8 1.2 Schematic Diagram of Scrubbing System 1-17 1.3 Rain Water Harvesting Schematic Diagram 1-24 1.4 Location of Storm Water Storage Tank 1-25 1.5 Green Belt Development of Hazelo Lab Pvt. Ltd. 1-34 1.6 Organ gram of the Environment Management Cell 1-36

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ENVIRONMENT MANAGEMENT PLAN

1.0 Introduction

Environmental protection is an issue that no organization can neglect and hope to survive.

The by-products of civilization are being dumped upon the environment to a degree that the

environment finds difficult to assimilate. The key to the success of the integrated approach to

pollution prevention and control is the management and operation of the organization.

Effective committed management delivers a successful industry. As total commitment to the

environment, not just for compliance with legal or regulatory compliance will be the essence

of environment management of an industry. Many companies have recognized the benefits

of implementing an effective environmental management system.

Environmental management plan can be effectively implemented to mitigate the pollution

levels by observing the following;

1. Pollution will be prevented or reduced at the source,

2. Pollution that cannot be prevented will be recycled in an environmentally safe manner,

3. Pollution that cannot be prevented or recycled will be treated in environmentally safe

manner, and

4. Disposal and other releases into the environment will be used “only as a last resort”

and will be conducted in an environmentally safe manner.

The management plan is drawn in consultation with the project proponents with reference to

various potential monitored, identified and predicted in the previous chapters. And the

necessary measures to be taken for the mitigation and control of the same presented, various

pollution control measures adopted which are present in the proposed expansion and

measures identified for adoption are discussed in the Environmental Impact Assessment

Report of the same are presented in appendix of the Environmental Impact Assessment

Report. Review of the process is the essential component of Environmental Management M/s.

Hazelo lab Pvt. Ltd. been conducting experiments to optimize the consumption of raw

materials and to increase the purity of the product.

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1.1 Environment Management Plan 1.1.1 Construction Phase As the unit is located near the road, potential of pollution during construction phase due to

transport of construction materials will be less compared to operational stage. However

industry will ensure that pollution potential in the construction phase is at a minimum.

Wherever applicable, detailed procedures will be developed for control of pollution during

project execution phase for expansion. Separate rooms will be provided for labors and

casual workers. The following measures are to be adopted to minimize pollution load during

construction phase.

Site Preparation

During site preparation considerable amount of soil movement is involved due to

excavation and levelling operations. During construction it is necessary to control uplift of

dust during excavation, levelling and transportation by water sprinkling along the

temporary roads and exposed soil areas. The clearing of plants, shrubs and trees will be

kept to a minimum so as to leave sufficient space for erection of mechanical units and for

civil construction.

Sanitation

Considering the standards of hygiene, the workers involved in construction will be provided

temporary toilets, and drinking water. The toilets will be attached to septic tank so as to

minimize the percolation and to control the subsequent impact on the environment. These

facilities will be properly designed and maintained to ensure minimum environmental

impact.

Noise

The site is located in a place where habitation is minimum and at distance of 0.65 Km. Thus

there will be insignificant impact due to noise on the inhabitants. The construction workers

on site will be provided with personal protective equipment like earmuffs whenever for

those who work near noise generating equipment/sources.

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Wastes from Construction Equipment

Construction activity involves a number of operations that utilize equipment like DG sets.

dozers, cranes etc. These equipment are a source of emissions and solid wastes. Proactive

maintenance to mitigate emissions, while the hazardous solid wastes of waste oils and used

batteries are sent to authorized recyclers. Construction debris shall be reused on site as sub

base for road construction. Spillage is avoided and spill control measures are adopted to

minimize contamination of soil and ground water resources. The empty containers of

paints, thinners etc shall be sold to authorized buyers.

1.1.2 Operation Phase

During operation stage the major pollution from the proposed expansion is from liquid

effluents from process, utilities and domestic facilities, and air pollution from utilities and or

combustion of fuels/wastes. The effluent treatment system based on zero liquid discharge

principle, shall convert most of the liquid effluents to solids by way of evaporation of salts

and ETP sludge. The environment management plan is drawn in consultation with the project

authorities, R&D experts of Hazelo Lab Pvt. Ltd., and other technical consultants involved in

preparing the project plan. The management, mitigation and enhancement measures

identified for significant impact sources are presented as follows;

2.0 Sources of Pollution from Manufacturing Process:

The major contributions of pollution from proposed expansion are effluent generation from

process, utilities and domestic sources and gaseous emission from process and utilities. The

water pollution is due to the effluent generated from process, washings, Scrubber, utility

blow downs and domestic sources. Majority of effluents generated will be from process and

it will have considerable amount of COD and TDS load and suspended solids, which has to

be effectively treated. The treatment of effluents, and recovery operations of solvents

generate salts and residues respectively, in addition to residues from process operations,

which are considered hazardous wastes. The air pollution is caused due to combustion of

both fuels and solid/gaseous wastes. The quantities and quality of effluents, emissions and

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solid wastes are identified and quantified in the environmental impact assessment study.

The environment management measures proposed are described as follows;

2.1 Water Pollution (Terms of Reference No. 3(vi) & 7(iv))

The effluents generated in the process, separation techniques and during purification

contain organic residues and inorganic raw materials, solvents, and products. Hence the

effluents contain both organic and inorganic salts in various quantities leading to high COD

and TDS levels respectively. Effluents from process, washings, Scrubbing media, and utility

blow downs will be sent to the effluent treatment system. The treated effluent will be

reused for cooling towers makeup and scrubbers. The total effluent generated and mode of

treatment is presented in Table 1.1. The quantity and quality of effluents generated from

process for each product is presented in Table 1.2.

Table 1.1 Total Effluents Generated and Mode of Treatment Description Quantity (KLD) Mode of Treatment

Permitted After Expansion

HTDS Effluents Process 4.52 102.56 Sent to Stripper followed by MEE and ATFD.

Stripper Condensate sent to Cement Plants for Co-Incineration. MEE and ATFD Condensate sent to Biological treatment plant followed by RO. RO rejects sent to MEE and permeate is reused in cooling towers make-up and scrubbers.

Washings 1 10

Scrubber Effluent 10 Sent to MEE followed by AFTD, Biological treatment plant and RO. RO/DM Plant

Rejects 24

Total I 5.52 146.46 LTDS Effluents

Boiler Blow downs 1 10 Sent to Biological Treatment System followed by RO. RO permeate reused for cooling tower makeup and scrubbers. RO rejects sent to MEE.

Cooling Tower Blow downs

0.5 26

Domestic 1 8.5 Total II 2.5 44.5 Grand Total (I+II) 8.02 191.06

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Table 1.2 Process Effluents Quantity and Quality – Product Wise S.No Name of Product Quantity (Kg/day) Concentration

(mg/l) Water Input

TDS COD Total Effluent

TDS COD

1 Amlodipine Besylate 3528.4 230 220.7 3894.1 59064 56675 2 Bupropion 3200 360 70.6 3601.1 99969 19617 3 Clopidogrel 3300 134.2 205.0 3707.5 36210 55288 4 Desvelofloxin 3000 9.6 148.5 3155.6 3040 47068 5 Divolproex Sodium 0 1.2 0 34.4 34121 0 6 Dulaxetine HCl 1100 46.8 52.4 1191 39258 43967 7 Esomeprazole MgTrihydrate 4833.5 241.3 146.7 5235.5 46081 28012 8 Glimepiride 1200 32.0 33 1260.1 25395 26167 9 Mesalamine 3600 312.3 65.7 4007.8 77931 16383 10 Metaprolol 3300 104.5 12.7 3441.3 30355 3679 11 Pantoprazole Na 3445 453.3 43.6 5055.7 89666 8634 12 Pragabalin 3578.7 307.6 228.9 4214.5 72980 54312 13 Rosuvastatin 1112.5 23.2 44.6 1158.9 19985 38497 14 Sertraline HCl 3500 111.3 338.7 3872 28754 87488 15 Tramadal 6053.6 454.5 200.7 6750.6 67329 29735 16 Valaciclovir 5555.1 253.1 491.3 6650.5 38064 73878 17 4-[4-Chloro-1-oxobutyl]-2, 2-

dimethyl phenyl acetic acid methyl ester

6500 528.0 55.2 7515.2 70264 7343

18 N2-(1-(S)-ethoxy carbonyl-3-phenyl propyl-N6-trifluoro acetyl- L-lysine

2700 122.9 122.7 3065.1 40094 40030

19 2-[2--[3(S)-[3-[2-(7-chloro-2-quinolinyl) ethenyl] phenyl]-3-hydroxy propyl] phenyl]-2-propanol.

4304.8 466.3 315.7 5944.0 78447 53108

20 2,8 -Diazo bicyclo Nonae 6000 345.8 131.5 6557.7 52727 20046 21 2,3,4,5-Bis-O- (1- methylethylidene)

-b-D-fructopyranose 6000 217.3 192.0 6522.4 33323 29442

22 2- Acetyl Ethoxy acetyl methoxy ether

80 5.9 1.1 86.6 68080 12702

23 N,N-Carbonyl di imidazole 0 0 0 0 0 0 24 (2S,3S,5S)-2-Amino-3-Hydroxy-5-

Tert-Butylcarbonyl Amino 1,6-diohenyl

3263.6 98.8 45.5 3440.8 28715 13233

25 Trans-4- (4-chlorophenyl)-cyclohexane carboxylic acid

2524 177.6 39.1 2740.9 64790 14264

26 Guanine 400 115.8 168.5 1742.3 66440 96721 27 Poly allyl amine HCl 3200 51.8 5.1 3271.8 15825 1547 28 Tert-butyl 2-((4R,6S)-6-((E)-2-(4-(4-

flurophenyl)-6-isopropyl-2-(N- 4808.7 286.7 126.0 5184 55313 24307

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methyl methane sulfonamido) Pyrimidin - 5-yl)vinyl)-2,2- dimethyl-1,3-dioxane -4-yl-) acetate

29 5-Cyano Phthalide 2300 20.0 68.2 2348 8518 29035 30 1,1-Cyclohexane diacetic acid 5588.7 72.7 353.4 5244.2 13854 67393 31 Carbamyl Methyl-5- Methyl

hexanoic acid 777.3 52.9 42.4 695.4 76056 60987

32 2',3'-Di-O-acetyl-5'-deoxy-5-fluorocytidine

1250.2 79.5 108 1411.2 56356 76550

33 N-(2-Methyl-5-aminophenyl)-4-(3-pyridyl)-2- pyrimidine amine

3400 116.9 102.7 3708.9 31513 27688

34 4-[(4-Methyl piperazin-1-yl) methyl] benzoic acid DiHCl

2154.6 50.5 46.7 2201.1 22948 21206

35 2, 3-Epoxy-2-methyl-N-[4-cyano-3-(trifluoromethyl) phenyl] propanamide

7500 286.1 192.9 7940.5 36032 24296

Total Worst Case: 20 Products on Campaign basis

91274.3 5521.1 4027.2 102556.5 53835 39268

2.1.1 Process Description and Technical Specification of Effluent Treatment System (Terms of Reference No. 7(iv) & Sp. TOR (5)) The Effluent management system is developed to ensure `Zero Liquid Discharge’.

Segregation of effluents is an integral part that facilitates effective treatment of various

effluent streams. The effluents are segregated into two streams; High COD/ TDS and Low

COD/ TDS streams.

The High TDS/ COD Effluents

The treatment system for treating High TDS / COD effluents consists of Equalization,

Neutralization, Settling tank, Stripper, Multiple Effect Evaporator (MEE) followed by

Agitated Thin Film Dryer (ATFD). The organic distillate from the stripper is sent to cement

plants for co-incineration and aqueous bottom from stripper is sent to MEE followed by

ATFD for evaporation. The condensate from the MEE and ATFD are sent to ETP

(Biological). Salts from ATFD are disposed to TSDF.

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The Low TDS/ COD Effluents:

These effluents along with the condensate from MEE and ATFD are treated in primary

treatment consisting of equalization, neutralization, and primary sedimentation followed by

secondary biological treatment consisting of aeration tank and clarifier.

The treated effluents after biological treatment are subjected to tertiary treatment in a reverse

osmosis (Double Stage RO) system. Permeate from RO is reused for cooling tower make-up

and scrubbers while rejects are sent to MEE followed by ATFD. Sludge from various units of

Biological treatment are thickened in sludge handling system and sent to TSDF. Schematic

diagram of effluent treatment system is presented in Fig 1.1. Details of treatment facilities are

presented in Table 1.3. Technical specifications of effluent treatment system are presented in

Table 1.4 and 1.5 respectively.

Table 1.3 Details of Treatment Facilities S.No Facility Description Capacity of Unit (KLD)

Installed Capacity

Total after Expansion

Operating Volume

1 Stripper 10 135 113.3 2 Multiple Effect Evaporator 10 200 161.2 3 Agitated Thin Film Dryer 5 50 39.8 4 Biological Treatment Plant 25 250 191 5 Reverse Osmosis Plant - I 20 250 191 6 Reverse Osmosis Plant - II 70 57.3

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Table 1.4 Technical Specifications of Effluent Treatment System S.No Description Unit After

Expansion Stripper

1 Design Capacity KLD 135 2 Feed Rate Kg/hr 4000-6000 3 Specific Gravity of Feed ≈ 1.03 4 Initial Feed COD PPM 20000-50000 5 Feed Total Solid % 2.0-4.0 6 High Heating Temperature OC 95 – 100 7 High COD Condensate recovery LPH 150-200 8 Dry Saturated Steam requirement at 3.0Kg/cm2 (g) TPH 0.8-1.2 9 Cooling Water circulation rate for condenser m3/hr 1.2-2.5 10 Cooling Water Inlet Temperature OC 30 – 32 11 Cooling Water Outlet Temperature OC 38 – 40

Multiple Effect Evaporator (MEE) 1 Design Capacity KLD 200 2 Feed Rate Kg/hr 7000-9000 3 Feed Concentration mg/l 30000-70000 4 Feed Temperature OC 30 5 Initial Solids % 5.0-8.0 6 Solids in Concentrate % 35.0-40.0 7 Concentrate Output Kg/hr 1500-2500 8 Water Evaporation Rate Kg/hr 5000-8000 9 Designed Water Evaporation Rate Kg/hr 6000 10 Dry Saturated Steam requirement at 6.0Kg/cm2 (g) TPH 3.0-4.0 11 Cooling Water Circulation Rate at 30 – 32OC m3/hr 10.0-15.0 12 Cooling Water Inlet Temperature OC 30 – 32 13 Cooling Water Outlet Temperature OC 38 – 40

Agitated Thin Film Dryer (ATFD) 1 Designed Capacity KLD 50 2 Feed Rate Kg/hr 1500-2500 3 Initial Feed Solid Content % 35.0-40.0 4 Final Moisture in Dry Bag-gable Product % 2.0-3.0 5 Water Evaporation Rate Kg/hr 1000-1500 6 Designed Water Evaporation Kg/hr 1200 7 Solid Output in Bag-gable form at 5 – 6% moisture Kg/hr 600-800 8 Dry Saturated Steam requirement at 6.0Kg/cm2 (g) Kg/hr 100-150 9 Cooling Water Circulation Rate at 30 – 32OC m3/hr 0.1-0.2 10 Cooling Water Inlet Temperature OC 30 – 32 11 Cooling Water Outlet Temperature OC 38 – 40

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Table 1.5 Technical Specifications of Biological Treatment Plant Data After Expansion Flow from MEE + ATFD : 146.5 KLD Boiler Blow down : 10.0 KLD Cooling Tower Blow down : 26.0 KLD Domestic : 8.5 KLD Total Flow to Neutralization tank : 191 KLD Design Capacity : 250 m3/day Flow : 191 m3/day BOD : 458 mg/l COD : 4589 mg/l Total Dissolved Solids : 513 mg/l BOD load : 88.5 kg/day COD load : 877 kg/day Total Dissolved Solids : 98 kg/day Neutralization Tank Average flow : 20.2 m3/hr Hydraulic retention time : 12 hrs. at peak flow Volume : 250 m3 Tank : 2 no. Proposed based on Daily flow. Aeration Tank - 1 BOD(yo) : 458 mg/l % of BOD removed : 80 BOD Load : 17.7 kg/day COD : 4589 mg/l COD Load : 877 kg/day Outlet BOD : 97 mg/l MLSS : 6000 mg/l F/M ratio : 0.18 Flow : 250 m3/day Volume of the Tank : 191 m3 Check for Detention time : 22.6 Hours (12 - 24) Assuming depth : 3.5 m (4.0+0.5 F.B) Area of the tank : 67.13 m2 Width of the tank : 8.19 m Length of the Tank : 4.10 m BOD5 load in the aeration tank : 206.37 Oxygen is required for every Kg of BOD5 to be removed

: 2.00 kgs

Oxygen requirement for areation : 412.74 kg/day O2 in Air % : 0.21 % Density of Air : 1.20 Oxygen requirement : 50.00 m3/kg O2/day Air Required : 20635.6 m3/day

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: 502.2 cfm Consider 35% excess considering the air required in the equalization tank. Total air required : 684.52 Kg O2/day Clarifier - 1 Design quantity : 250 m3/m2-day Surface loading rate of average flow : 12 m2 Surface area provided : 20.8 m length of the tank (2l=b) : 4.56 m (Say 4.5 m) Width of the tank : 2.28 m (Say 2.5 m) Aeration Tank - 2 BOD(yo) : 144 mg/l % of BOD removed : 80 BOD Load : 29.3 kg/day COD : 288 mg/l COD Load : 59 kg/day Outlet BOD : 29 mg/l MLSS : 5500 mg/l F/M ratio : 0.18 Flow : 250 m3/day Volume of the Tank : 227.3 m3 Check for Detention time : 21.8 Hours (12 - 24) Assuming depth : 3.5 m (4.5+0.6 F.B) Area of the tank : 64.94 m2 Width of the tank : 8.06 m Length of the Tank : 4.03 m BOD5 load in the aeration tank : 29.25 Oxygen is required for every Kg of BOD5 to be removed

: 2.00 kgs

Oxygen requirement for aeration : 58.51 kg/day O2 in Air % : 0.21 % Density of Air : 1.20 Oxygen requirement : 50.00 m3/kg O2/day Air Required : 2925.29 m3/day : 71.87 cfm Consider 35% excess considering the air required in the equalization tank. Total air required : 97.03 Kg O2/day Clarifier - 2 Design quantity : 250 m3/m2-day Surface loading rate of average flow : 12 m2 Surface area provided : 20.8 m length of the tank (2l=b) : 4.56 m (Say 4.5 m) Width of the tank : 2.28 m (Say 2.5 m)

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Holding tank The flow from the each individual settling tank i.e., the supernatant liquid is let into the respective Pre-Filtration Tank, which has a minimum 8 hours holding capacity. This tank is provided to hold the treated effluent and give an even flow to the pressure sand filter. Average flow : 20.8 m3/hr Peak factor : 2 m3/hr Peak flow : 41.7 m3/hr Provide min 1.5 hours holding capacity. Hence required volume of the tank : 62.5 m3 Pressure Sand Filter: Vertical down flow type with graded/sand bed under drain plate with polysterene strains. Flow : 250 m3/day Rate of filtration assumed as : 15 m3/m2/hr Requirement of treated water for usage in 20 hrs : 12.5 m3/hr Dia of filter of 1 nos. : 1030.33 mm Provide a Pressure Sand filter of 1100 mm say 1250 mm dia with sand as media over layer, under drain pipe, laterals face piping etc., Activated Carbon Filter: Vertical down flow type with graded/sand bed under drain plate with polysterene strains. Flow : 250 m3/day Rate of filtration assumed as : 15 m3/m2/hr Requirement of treated water for usage in 20 hrs : 12.5 m3/hr Dia of filter of 1 nos. : 1030.33 mm Provide activated carbon filter of 1100 mm say 1250 mm dia with sand as media over layer, under drain pipe, laterals face piping etc., Reverse Osmosis -1: Design Capacity : 250 KLD Operating capacity : 191 KLD Recovery : 70% RO Permeate : 133.7 KLD RO rejects : 57.3 KLD Reverse Osmosis - 2: Design Capacity : 70 KLD Operating capacity : 57.3 KLD Recovery : 70% RO Permeate : 40.11 KLD RO rejects : 17.19 KLD

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2.2 Air Pollution (Terms of Reference No. 3(vi))

The manufacturing process consists of reaction, separation and purification. The reaction is

conducted in closed reactors, while the separation is conducted in centrifuge, filtration

equipment etc. Purification would be conducted in reactors or filtration equipment. The

transfer of materials will be through closed pipelines. Various sources of emissions are

identified from process operations. The usage of boiler for steam generation and DG sets

for emergency power back up also releases emissions.

2.2.1 Emissions from Utilities (Terms of Reference No. 7(v)

The sources of air pollution are from proposed 2 x 10 TPH coal fired boiler, existing 1 x 2

TPH and existing 1 Lakh K.Cal thermic fluid heater. Backup DG sets of 2 x 1000 KVA are

proposed in addition to existing DG sets of 1 x 250 KVA capacity to cater energy

requirement during load shut downs. Bag filter will be provided as air pollution control

equipment for 2 x 10 TPH coal fired boilers. DG sets shall be provided with effectivestack

height based on the CPCB formula. The emission rates of SO2, NOx and SPM from each

stack are presented in Table 1.6. Technical specifications of Bag filters presented in Tables

1.7

Table 1.6 Emission Details of Pollutants from Stack S.

No

Stack Connected to Stack Ht (m)

Dia of stack at top(m)

Temp. of exhaust

gases (0C)

Exit Velocity (m/sec)

Pollutant Emission Rate (g/sec)

SPM SO2 NOx Existing

1 2TPH Coal Fired Boiler

15 1 180 4.5 1.12 0.04 0.13

2 1 lakh K.Cal/hr Thermic Fluid heater

15 0.32 127 7.96 0.16 - 0.004

3 250KVA DG Set 4 0.2 320 5 0.004 0.002 0.01 Proposed

1 2X10 TPH Coal Fired Boiler

35 1.45 190 6.05 0.63 0.72 0.3

2 2X1000KVA DG set 10 0.2 180 8 0.01 0.02 0.03 *DG sets will be used during load shut down by TSPDCL.

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Table 1.7 Technical Specifications of Bag Filters S.No Application Unit Value/Description

1 Boiler Capacity TPH 10    Fuel    Coal

2 Gas Volume m3/hr@170 degC 28000    Gas Temperature Deg C 180    Outlet emission mg/Nm3 <50    Flange to flange pr. drop mmWC 140    Moisture Content % 8.7    No. of Bags 268    Filter area per bag m² 1.72    Total filter area m² 460    Air to cloth ratio m³/min/m² 1.15

3 Bags      Diameter ID, mm 160    Length mm 3650    Material Nomex    Max. operating temp. degC 190

4 Bag Cleaning      Compressed air required Nm3/Hr 5-7 kg/cm2    No. pulse cum solenoid valve 10    Size of pulse valve NB 40

5 Material of Construction      Casing MS

a Tube Sheet MS    Cage MS    Hopper MS

7 Terminal Points      Dirty air Inlet of Poppet Valve, Flanged end    Clean air Outlet of Bag Filter, Flanged end    Dust discharge RALV    Compressed air Inlet of Air Header    Electricals Power Supply for Timer 230 V Ac

2.2.2 Emissions from Process

The source of process emissions are reactors, where gaseous products are released, or excess

gaseous raw material used in production, which mainly contain inorganic gases. The other

emissions from process operations and effluent treatment system are mainly known as

diffuse emissions containing dusts, fumes and volatile organic compounds. The VOCs from

among the diffuse emissions are the main cause of odour in the plant area and its

neighborhood. Spillage, leakage and accidental releases are the causes of fugitive emissions,

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releasing solids, liquids and fumes of volatile organic compounds resulting in soil and

ground water contamination in addition to odour in the plant area.

a. Process Emissions: The process emissions contain Ammonia, Carbon dioxide, carbon

monoxide, Hydrogen, Hydrogen Bromide, Bromine, Hydrogen Chloride and Sulfur

dioxide. Ammonia, Hydrogen chloride, Hydrogen Bromide, Bromine and Sulphur dioxide

are sent to scrubber in series. Ammonium Chloride from ammonia scrubbing, Sodium

chloride from HCl scrubbing, Sodium bromide from HBr and Bromine Scrubbing and

Sodium Bisulfite from Sulphur dioxide Scrubbing are sent to ETP. The other gases Carbon

dioxide and carbon monoxide are let out into atmosphere following a standard operating

procedure, while Hydrogen gas is let out into atmosphere through a water column.. The

quantity of process emissions is presented in Table 1.8. Schematic diagram of Scrubbing

system is presented in Fig 1.3. Techncial Specifications of two stage scrubber is presented in

Table 1.9

Table 1.8 Quantity and Mode of Treatment of Process Emissions Product Name Stage Name of Gas Quantity

(Kg/Day) Mode of treatment

Bupropion I

Hydrogen Bromide 529.8 To Scrubber Hydrogen Chloride 14.3 To Scrubber

Desvelofloxin I

Carbon dioxide 41.8 Let out into atmosphere Hydrogen 0.2 Let out into atmosphere

through water column Divolproex sodium I Carbon dioxide 176.8 Let out into atmosphere Esomeprazole Mg I

Hydrogen Chloride 60.1 To Scrubber Hydrogen 0.2 Let out into atmosphere

through water column Rosuvastatin I Hydrogen 1.6 Sertraline Hcl I Hydrogen 5.8 Valaciclovir II Hydrogen 1.2 N2-(1-(S)-ethoxycarbonyl-3-phenylpropyl-N6-trifluoro acetyl)-L-Lysine

II Hydrogen 4.4

2-[2--[3(S)-[3-[2- (7-chloro-2-quinolinyl) ethenyl] phenyl]-3-hydroxypropyl] phenyl]-2- propanol.

I Carbon dioxide 11.6 Let out into atmosphere

(S,S)-2,8-diazabicyclo[4.3.0] nonane

II Hydrogen 0.1 Let out into atmosphere through water column IV Hydrogen 0.4

Aminohydroxy butyloxy II Carbon dioxide 12.8 Let out into atmosphere

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diphenylhexane Hydrogen 0.6 Let out into atmosphere through water column III Hydrogen 0.1

Trans-4-(4-chlorophenyl) cyclohexane carboxylic acid

II Carbon monoxide 11.7 Let out into atmosphere

Tert-butyl 2-((4R,6S)-6-((E)-2-(4-(4-flurophenyl)-6-isopropyl-2-(N- methyl methane sulfonamido) Pyrimidin - 5-yl)vinyl)-2,2-dimethyl-1,3- dioxane-4-yl-) acetate

III Bromine 23.4 To Scrubber

5 Cyano Phthalide I

Sulfur dioxide 547.3 To Scrubber Hydrogen Chloride 624.3 To Scrubber

II

Sulfur dioxide 439.2 To Scrubber Hydrogen Chloride 501.0 To Scrubber

1,1-cyclohexane di aceticacid

I

Ammonia gas 566.7 To Scrubber Carbon dioxide 733.3 Let out into atmosphere

3-Carbomylmethyl-5-methyl hexanoic acid

I

Ammonia gas 227.3 To Scrubber Carbon dioxide 352.5 Let out into atmosphere

N-(2-Methyl-5-aminophenyl)-4-(3-pyridyl)-2-pyrimidine amine

II Hydrogen 3.9

Benzoic acid, 4-[(4-methyl-1-piperazinyl) methyl] dihydrochloride

I

Hydrogen Bromide 87.8 To Scrubber Ammonia gas 18.5 To Scrubber

2,3-Epoxy-2-methyl-N-[4-cyano-3-(trifluoromethyl) phenyl]propanamide

I

Sulfur dioxide 62.2 To Scrubber Hydrogen chloride 35.5 To Scrubber

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Fig 1.2 Schematic Diagram of Scrubbing System

Table 1.9 Technical Specifications of Two Stage Scrubber

Type Packed Tower Scrubber Two Stage MOC PP/FRP 5 mm PP+8mm FRP Air Flow Rate 2500CFM Inlet Temp. 350C Inlet Gas Pressure Atmospheric Batch 24 Hrs Scrubbing medium for IstStage Water 10% NaOH Solution Scrubbing medium for IIndStage Caustic Solution (or) Acid Blower MOC PPFRP Capacity 2500CFM Suction Pressure − 250mmWC Discharge Pressure 60mmWC HP/RPM 5HP/1900RPM Circulation System Flow Rate 15 M3/hr Head 30 Meters Motor Make FLP MOC PP Make Antico Storage/ Recirculation Tank Capacity 3 KL Size 1700mm Dia X 2300mm Ht. MOC PP/FRP

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2.2.3 Diffuse Emissions

Emissions are also released from various operations of manufacturing like centrifuge,

drying, distillation, extraction etc.. These emissions mainly contain volatile contents of the

material sent for processing. The emissions are normally passed through vent scrubber

before releasing into atmosphere to mitigate odour. The emissions from distillation are

passed through condensers, which mitigate odour. It is proposed to provide vent

condensers in series to reactors, distillation columns, driers and centrifuge etc. to mitigate

VOC emissions release. Other vents are connected to common headers and scrubbers. The

transfer pumps shall be provided with mechanical seals. The transfer of solvents shall be

mainly by closed pipeline systems, while drum transfer is by using air operated diaphragm

pumps in closed hoods. The charging of solid raw materials shall be by using closed

hoppers to avoid dust emissions and hazard of static electricity. Breather valves shall be

provided to storage tanks. Thermal insulation and condensers will be provided for storage

tanks of low boiling point solvents. The reactor or solvent storage tank vents when not use

shall be kept closed.

2.2.4 Fugitive Emissions (Terms of Reference No. 7(vi)

Fugitive emissions are anticipated from equipment leakage and transfer spills. The periodic

maintenance program shall ensure integrity of equipment mitigating the equipment

leakage. The spills however shall be managed by adopting the spill management scheme as

mentioned in the respective MSDS, spill control kit shall be provided in storage, and

production blocks. The fugitive emissions shall be reduced by closed transfer and handling

of all hazardous solvents and chemicals. The ventilation system provided will reduce health

impact on the employees by way of dilution of work room air and also dispersion of

contaminated air.

2.2.5 Odour Management (Terms of Reference No. Sp. TOR (6))

Odour is caused mainly by diffuse and fugitive emissions of low boiling organic chemicals/

compounds releasing volatile organic compounds. The above mentioned measures for

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mitigation and control of diffuse and fugitive emissions shall reduce release of VOC’s into

atmosphere and the resultant odour.

2.3 Solvent Use and Recycle

Solvents are used for extraction of products and as reaction medium. Solvents constitute

major consumable material of synthetic organic chemical manufacturing, mainly used as

reaction medium. The used solvents constitute major waste stream of synthetic organic

chemical manufacturing. Hence it is proposed to recycle the solvents by distillation for reuse

in process, thereby reducing total solvent consumption in the plant and reducing the waste

quantity to be disposed. The distillation columns are mainly provided to remove moisture and

impurities from spent single solvents, and mixed solvents. The recycled single solvents are

reused in the process, while the mixed solvents are sold to end users. Distillation process

generates residues which are mainly organic in nature containing significant calorific value,

and can be sent to cement plants for co-incineration as fuel. The total solvent balance product

wise and stage wise is presented in Table 1.10.

Table 1.10 Total Solvent Balance – Product Wise after expansion

S.No Product Name Quantity (Kg/Day) Solvent

Quantity Recovered Fugitive

loss To waste

water Residue

1 Amlodipine Besylate 4250 4033 28.9 27.6 160.5 2 Bupropion HCl 13250 12832.3 57.1 27.5 333.2 3 Clopidogrel Hydrogen Sulfate 7700 7441.5 36.3 44 178.2 4 Desvelofloxin Succinate 4500 4356.5 20 38 85.5 5 Divolproex Sodium 2000 1940.0 5 0 55 6 Dulaxetine HCl 2922 2775.9 23.4 36 86.7 7 Esomeprazole Mg Trihydrate 13072 12478.4 104.6 122.9 366.1 8 Glimepiride 2300 2244.5 12.4 8.1 35 9 Mesalamine 0 0 0 0 0 10 Metaprolol 3500 3395 15.5 0 84.3 11 Pantoprazole Sodium

Sesquihydrate 3850 3726.5 30.8 26.5 66.2

12 Pragabalin 6000 5700 48 180 72 13 Rosuvastatin Calcium 2550 2468 20.4 21.4 40.2 14 Sertraline HCl 5150 4892.5 41.2 154.5 61.8 15 Tramadal 6500 6175 52 195 78 16 Valaciclovir HCl Monohydrate 12349.8 11999.3 55.9 60.3 234.3 17 4-[4-Chloro-1-oxobutyl]-2, 2- 3441.5 3331.8 8.3 6.4 95

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dimethyl phenyl acetic acid 18 N2-(1-(S)-ethoxy carbonyl-3-

phenyl propyl-N6-trifluoro acetyl-L-lysine

4500 4343 22.4 36.7 97.9

19 2-[2-[3(S)-[3-[2-(7-Chloro-2-Quinolinyl)-ethenyl]phenyl]-3-hydroxypropyl]phenyl-2-propanol

6150 5948.8 28 24.2 149.1

20 2,8-Diazo bicyclo Nonane 12450 12054 58.9 0 317.2 21 2, 3, 4, 5-Bis-O- (1-

methylethylidene)-b-D-fructopyranose

4950 4702.5 39.6 20.9 187

22 2-Acetyl Ethoxy acetyl methoxy 0 0 0 0 0 23 (1,1) Carbonyl di imidazole 8500 8287.5 42.5 0 170 24 (2S, 3S, 5S)-2-Amino-3-Hydroxy-

5-Tert-Butylcarbonyl Amino 1, 6-diohenyl

3000 2879.5 18 28.5 74

25 Trans-4-(4-chlorophenyl)-cyclohexane carboxylic acid

2450 2365.8 12 23 49.3

26 Guanine 0 0 0 0 0 27 Poly allyl amine HCl 0 0 0 0 0 28 Tert-butyl 2-((4R,6S)-6-((E)-2-(4-

(4-flurophenyl)-6-isopropyl-2-(N- methylmethane sulfonamido)Pyrimidin - 5-yl)vinyl)-2,2-dimethyl-1,3-dioxane-4-yl-) acetate

6850 6576 13.7 68.5 191.8

29 5-Cyano Pthalide 10000 9600 20 28 352 30 1,1-Cyclohexanediacetic acid 8000 7760 20 47.8 172.2 31 Carbamyl Methyl-5-Methyl

hexanoic Acid 3700 3589 5.5 22.3 83.3

32 2',3'-Di-O-acetyl-5'-deoxy-5-fluorocytidine

2950 2843.5 24.1 25.4 57

33 N-(2-Methyl-5-aminophenyl)-4-(3-pyridyl)-2-pyrimidine amine

9000 8730 26.5 79.5 164.1

34 4-[(4-Methylpiperazin-1-yl) methyl] benzoic acid diHCl

1950 1891.5 4.9 19.5 34.1

35 2, 3-Epoxy-2-methyl-N-[4-cyano-3-(trifluoromethyl) phenyl] propanamide

4220 4075.2 29.4 42 73.4

Total Worst Case: 20 Products on campaign basis

145585.3 140409.4 678.8 885.5 3586.3

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2.4 Solid Waste (Terms of Reference No. 3(vi) & 7(vii))

Solid wastes are generated from process, solvent distillation, wastewater treatment and

utilities. Process residue contains mainly unreacted raw materials and byproducts. These are

collected from the reactors and other process equipment and stored in drums. Solvent residue

is generated from distillation units, the residues are tarry substances with good calorific

value, and are stored in drums. The other major waste is salts from multiple effect evaporator

and agitated thin film dryer section of effluent treatment system. These salts are stored in

HDPE lined bags. All solid waste storage containers/drums/bags are labeled showing the

source, nature of hazard and type of wastes. All the hazardous wastes are stored in a closed

shed with fire safety measures, and the shed is provided with a leachate collection facility

connected to effluent conveyance lines. The stripper distillate, process residue and solvent

residue are sent to cement plants for co-incineration based on acceptability. If these wastes

are not suitable for co-incineration, the same is sent to TSDF facility. Mixed solvents shall be

sent to authorized recyclers /cement plant for co-incineration while spent solvents are

recovered within plant premises. The evaporation salts are sent to TSDF. Filter media,

activated carbon and catalysts are sent to TSDF. Waste oil and used batteries from the DG

sets are sent to authorized recyclers. The sludge from effluent treatment plant is considered

hazardous and the same is sent to TSDF. The other solid wastes expected from the unit are

containers, empty drums which are returned to the product seller or sold to authorize buyers

after detoxification. The quantity and disposal plan for the solid wastes is presented in Table

1.11.

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Table 1.11 Solid Waste and Mode of Disposal S.No Description Units Quantity Mode of

Treatment/Disposal Permitted After Expansion

1 Solvent residue TPD 0.033 3.58 Sent to TDSF/Cement Plants for Co-incineration 2 Process Organic

residue TPD 9.12

3 Stripper Distillate KLD 3.4 4 Spent Carbon Kg/day 33.33 368 5 Spent Solvents KLD 1 126.4 Recovered within the

plant premises. 6 Spent Mixed Solvents KLD 0.66 14 Sent to authorized

recovery units/Cement plants for co-incineration

7 Inorganic residue TPD 3.77 Sent to TSDF 8 Hyflow Kg/day 78 9 Catalyst Kg/day 200 10 Evaporation salts TPD 1.33 11.92 11 ETP Sludge TPD 0.65 12 Ash from Boiler TPD 40 Sold to Brick manufactures 13 Detoxified containers No.s/

month 50 650 Sold to authorized

vendors 14 Waste oil KLPA 5.88 Sent to Authorized

Recyclers 15 Used batteries No.s/Yr 20

2.5 Noise Pollution

Noise is anticipated from motors, compressors and DG set. The DG shall be kept in a

separate enclosed room with acoustic enclosure. The motors and compressors shall be

provided with guards and shall be mounted adequately to ensure the reduction of noise and

vibration. The employees working in noise generating areas shall be provided with

earmuffs. The employees shall be trained in the mitigation measures and personal

protection measures to be taken to avoid noise related health impacts.

Measures to Control Noise Pollution

An effective hearing conservation program will be undertaken where exposure to industrial

noise is capable of producing hearing loss. The objective is to ensure that an employee

hearing is not affected during his working life to an extent greater than that usually

occurring with age and to preserve it at a level sufficient for normal speed perception.

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The following engineering control aspects are identified for further implementation to

reduce noise levels/exposure;

• The noise generating sources like motors and compressors will be provided with

Casings and guard to reduce the noise levels

• Placing attenuating screens between the operators and the sources.

• Adequate spacing between noise sources and operators will be provided. In free field

conditions the sound levels roughly varies with the square of the distance.

• Reflected noise is reduced by use of absorbent materials on roofs, walls and floors.

• By proper maintenance, which corrects vibrations and other imbalances, will be taken

up.

• Necessary vibration mitigation measures to ensure least impact on structures and

workmen.

• Personal protective equipment: ear plugs and muffs consisting of fine glass wool, ear

muffs consisting of ear cups with a soft seal, fitted with a spring or adjustable

headband. Comfort, maintenance and cleaning are important aspects of use.

• Plantation of tall as well as short trees around the plant area will protect the outside

environment from any noise and dust nuisance.

• It is possible to reduce the noise levels by 3-5 dB (A) per 30-m width of the green belt.

3.0 Rainwater Harvesting (Terms of Reference No. 7(x)

Rain water harvesting shall be adopted by providing rain water harvesting structures along

the drains, storm water storage sump and tanks. Storm water drains are provided with rain

water harvesting structures which will act as flow dissipaters and also as infiltration

trenches. Filtration points shall ensure percolation of water and enhance the ground water

table. The site area will be provided with 25 nos. of rain water harvesting structures. The

roof water shall be collected in 200 KL capacity sump connected to down spouts of the roofs,

and the collected water shall be reused for process and green belt development. The storm

water from open areas, and green belt area, and the overflow of the roof water storage sump

shall be collected in a storm water storage tank in southeast part of the site and reused for

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plant and process. The storage pond shall have a capacity of 3000 m3. These measures shall

ensure reuse of stored storm water for about 57 days of plant operation expansion. The

storm water is quantified using rational formula, for a rainfall intensity of 854.6 mm, with

constant of 0.5 for open area and 0.3 for green belt area. The total water that can be stored is

in the order of 17205 m3/year. The storage tank and the sump shall get refilled during

intense rain fall periods, and the stored water shall be reused mainly during monsoon and

post monsoon seasons. The location of storm water storage tank, roof water storage sump is

presented in Fig. 1.5 and storm water management is presented in Table 1.12. The

schematic diagram for rain water harvesting structure is presented in Fig 1.5.

Fig 1.3 Rain Water Harvesting Schematic Diagram

Table 1.12 Storm Water Management Land Use Area

in Ha Vol./hr after development

C=0.8 (KL)

Vol./hr before development

C=0.6 (KL)

Difference in Discharges (KL)

Roof Area 2.72 871.8 653.8 217.9 Road Area 4.09 1307.7 980.8 326.9 Open Area 6.81 817.3 1634.6 -817.3 TOTAL 13.62 -272.43 *C=0.3 after development of greenery Area of Catchment, ‘A’ 13.42 Ha Run off Coefficient, ‘C’ 0.5 Maximum intensity of rainfall, ‘I’ 854.6 mm/year Therefore Q 57351 m3/year Storm water Storage (30% run off) 17205 m3/year Water requirement 300.73 KLD No of days usage (Storm water) 57 Storm water storage pond 2000 m2 Storm water storage pond Depth 1.5 m

Total Storm water storage pond Capacity 3000 m3

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S C A LE 1C m = 00 m trs

P RO D U C TIO N BL O C K4 0.0x 12.5

PR O PO SED B LO CK4 0.0x 19.0

40.0x 12 .5

8 .0X 1 2.5MR O A D 5 .0 M

D CPRO P O SED

1 4.0 X 12.5MT A N K S

R O A D 5.0 M

R O A D 7 .0 M

SO LV EN T Y A R D4 5.3x60 .0

L RM -II

4 0.0x 20.0

U N LO A D IN G

P RO P O SE D B LO C K4 0.0x 19.0

IN TER M E D IA T E STO RA G E

Q C& Q A

PRO PO SED

7 0.0x19 .0

PR O PO SED SER V IC E B L O CK7 0.0x12 .5

R O A D 5 .0 M

40.0x 20 .0

2 8.0x20 .0

4 0.0x20 .0

7 0.0x 20 .0

R O A D 5 .0 M

4 0.0x 20 .0

4 0.0x20 .0

7 0.0x 20 .0

R O A D 5.0 M 2 5.0x 12 .5B O ILER2 0.0x12 .5

C O A L SH ED

P RO PO SE D B LO C KPR O PO SED B LO CK

W A RE H O U SE-I

L RM -I

5 0.0x20 .0

4 0.0x 20 .0

W A R EH O U SE-II

C A N TE EN &C H A N G E RO O M S

PR O PO S E D B LO CK

PR O PO SE D PILO T PLA N T

1 0.0x 10.0

T EM PLE

FU T U R E

FU T U R E

FU T U R E

Z LD System

FU T U R E FU T U R E

FU T U R EFU T U R E

FU T U R E

S TO R M W A TERPO N D

Fig 1.4 Location of Storm Water Storage Tank

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4.0 Occupational Safety and Health (Terms of Reference No. 8(iii)

Many worker health and safety hazards are posed by synthesis operations. They include

safety hazards from moving machine parts, pressurized equipment and pipes, heavy

manual handling of materials and equipment, steam, hot liquids, heated surfaces and hot

workplace environments, confined spaces and hazardous energy sources (e.g., electricity);

and high noise levels.

Acute and chronic health risks may result from worker exposures to hazardous chemicals

during synthesis operations. Chemicals with acute health effects can damage the eyes and

skin, be corrosive or irritating to body tissues, cause sensitization or allergic reactions or

be asphyxiants, causing suffocation or oxygen deficiency. Chemicals with chronic health

effects may cause cancer, or damage the liver, kidneys or lungs or affect the nervous,

endocrine, reproductive or other organ systems. Worker exposure to chemicals can occur

during manufacturing when chemicals spill, leak, or discharge from the process system and

contaminate areas where workers are present. The most frequently reported industrial

exposure occurs during the transfer of materials. The entry of workers into systems,

equipment, or enclosures that are contaminated may occur inadvertently, but routine

servicing, nonscheduled maintenance, and process monitoring appear to be the kind of

activities with potential for significant exposure. Health and safety hazards may be

controlled by implementing appropriate control measures (e.g., process modifications,

engineering controls, administrative practices, personal and respiratory protective

equipment).

The process modification shall be a constant exercise of the Research and development wing

of the organization, resulting in reduced pollution loads, and increased yields. The measures

proposed are selection of alternative solvents/routes of synthesis, avoidance of hazardous

chemicals usage, and application of green chemistry principles.

The engineering controls for reducing occupational hazards are provision of scrubbers,

condenser systems for process equipment, piping systems, insulation to reactors, usage of

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transfer pumps with mechanical seals, AOD pumps, trolleys for transfer of drums or bags,

closed hoods for charging raw materials, dip pipe provision for solvent and liquid raw

material charging, level indicators, pressure and temperature indicators, barrier guards on

moving machine parts, optimization of chemical inventory, control switches and emergency

stop devices to mitigate and avoid physical, chemical, electrical and mechanical hazards.

Work practices proposed for improving occupational safety are induction training programs,

safety training programs, rotation of workers, implementation of proactive maintenance

schedule, provision of standard operating procedures for all plant operations, access to

MSDS for all employees, access to emergency numbers of contact, and avoidance of crowded

work place, and provision of occupational safety centre.

Personal protective equipment shall be provided to all the employees including contract

employees. All the employees shall be provided with gumshoe, helmet, masks, and goggles.

The other equipment like ear muffs, gloves, respirators, aprons etc., will be provided to

employees depending on the work area allocated to them. The PPE selection shall strictly

follow the prescribed guidelines of MSDS. The budget allocated for personal protective

equipment is Rs. 60 lakhs and Rs. 20 lakhs for health checkup.

4.1 Medical Check-up (Terms of Reference No. 8(ii)

M/s Hazelo Lab Pvt. Ltd., has a medical program of pre employment screening, periodic

medical examination, emergency treatment, non emergency treatment, and record keeping

and review. The pre employment screening and periodic medical examination shall follow

the guidelines of factories act. The pre employment screening shall obtain medical history,

occupational history followed by physical examination and baseline monitoring for specific

exposures. The frequency of periodic medical examination and type of evaluation is

presented in Table 1.13.

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Table 1.13 Frequency of Health Monitoring

Occupation Type of evaluation Frequency Process area Dermatology examination, ophthalmic examination,

ENT examination, physical examination, complete blood picture, complete urine examination, ECG, Random blood sugar, Lipid profile, Liver function test, kidney function test, Anemia profile, thyroid stimulating hormone, abdomen ultra sound scanning, thread mill test, Spirometry test.

Once a year for regular employees. Half yearly for contract employees

Noise prone areas

Audiometry Annually

The plant shall have an occupational health centre to provide emergency and non emergency

treatment, by way of emergency first aid on site, liaison with local hospitals and specialists,

arranging decontamination of victims, arranging transport of victims to hospitals, and to

transfer medical records, and to provide details of incident and medical history to next care

provider. The occupational health centre shall be supervised by a qualified physician. The

occupational health centre shall maintain the health records and shall analyse the records for

any common symptoms and common health problems which may be due to exposure to

chemicals, and or due to other occupational hazards.

4.2 Handling of Toxic Chemicals/Materials

The engineering controls proposed for reducing occupational hazards in handling of toxic

chemicals are as follows;

Separate Storage area with environmental controls Dispensing of material in isolated dispensing booth with cross ventilation

Transfer of toxic powders by Power Transfer System (PTS)

Level Indicators, sensors, pressure & Temperature indicators provision to reactors

Transfer by dedicated pipe line

Dump tank system in case of overflow

Transfer by using AOD pumps in case of Drum transfer

Vents connected to common scrubbers.

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Administration Controls for handling of toxic chemicals are as follows;

All chemicals are stored based on respective MSDS

Periodic health check-up tuned to Toxic chemicals handled.

All employees are provided with respiratory protection ranging from nose mask to full

body suit to prevent toxic chemicals impacting respiratory system of employees.

Personal Protective Equipment (PPE) based on requirement and suitability.

5.0 Prevention, maintenance and operation of Environment Control System

The pollution control equipment, and the effluent treatment systems and effluents will be

monitored periodically and will be checked for its performance and pro-active maintenance

will be adopted. The environmental monitoring results will be evaluated to identify the

problems/under performance of the equipment. Necessary steps will be taken to rectify the

identified problems/defects. The management agrees that the evaluation of the performance

of pollution control measures and occupational safety measures to arrive at their efficiency

and proposes to adopt new measures for efficient pollution control which will be a regular

exercise.

All pollution control equipments are adequately designed and operating staff of the

pollution control equipment have good experience in the operation and maintenance of the

equipment. Standby equipment provided for all critical equipment to ensure continuous

operation of pollution control equipment and preventive maintenance is done as per the

schedule to avoid breakdown. Characteristics of influent and effluent are monitored on daily

basis by the industry and air emissions and effluent characteristics on monthly basis by third

party.

6.0 House Keeping

Good house-keeping practices will be adopted. Floor washing is avoided and wet mopping

will be adopted to minimize liquid waste generation. Paper waste is minimized by adopting

intra office network. Sufficient workspace and proper lighting will be provided.

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7.0 Socio Economic Environment (Terms of Reference No. 11(i)

The expansion of project provides an opportunity for the local people to get employment

directly or indirectly and helps in the up liftment of the socioeconomic status of the area. The

project proponents propose to involve in social activities of the stakeholders/surrounding

community by planning the betterment of neighbouring social conditions through awareness

and welfare programs will ensure an improved relation, useful in the long run. Many of the

beneficiaries of such programs shall include own employees as well. The goodwill of the

local populace can never be ignored. Another important facet of social environment

identified by the project proponents is a green appearance, hence the management will

develop a green belt towards aesthetic beautification as the same is necessary to be

considered as a responsible, social neighbour. The budget allocated for funding corporate

social responsibility activity is Rs. 112.5 lakhs or 2.5% of the capital cost to be spent during

the first 5 years of the project. The development programs are identified from schedule VII

of companies act 2013. A tentative list of development programs to be adopted as part of

CSR activity, with approximate budget allocation is presented in Table 1.15. The expenditure

shall be mainly towards gender development, skill development, and provision of

infrastructural facilities for drinking water, education and health. The programs identified by

the management as part of corporate social responsibility program are presented in Table

1.14.

Table 1.14 Corporate Social Responsibilities – Budget (2017-18 to 2021-22) S.

No Description TOTAL COST (Rs. IN LAKHS)

2017-18 2018-19 2019-20 2020-21 2021-22 1 Skill Development Training Programme 5 5 5 6 6 2 Drinking Water Facility 6.5 6.5 6 5 5 3 Health Camps 6.5 6 6 5 5 4 Education 5 5 5 6.5 6.5 Total (Rs. Lakhs) 23 22.5 22 22.5 22.5

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Table 1.15 Activity Wise CSR – Budget (2017-18 to 2021-22) – Program S.

No Description TOTAL COST (Rs. IN LAKHS)

2017-18 2018-19 2019-20 2020-21 2021-22 1 Socio-economic Development &

Enriching Livelihood 8.5

8.5

8.5

9

9

Includes activities relating to income generation like skill development programs, Roads, Drinking water facility, sanitation to nearby villages.

2 Value addition and necessary improvements in Government Schools

6 6 6 6.5 6.5

Includes construction of toilet blocks, carrier counseling, promoting education, including special educational and employment enhancing vocation skills for students, etc.

3  Care for the Needy 1.5 1.5 1.5 1.3 1.3 Eradicating hunger, poverty and malnutrition. Identification of old age homes, orphanage, differently abled persons, etc. Take care of their requirements.

4 Health & Environment 6 5.5 4.5 4.5 4.5 Conducting general health camps in the nearby villages, government schools, Creating environmental awareness, display of materials, sapling of trees, etc.

5 Infrastructure 1.5 1.2 1.2 1 1 Take care of the local community by construction of bus shelters, providing facilities in the Government Primary Health Centers, Government Hospitals.

Total (Rs. Lakhs) 23.5 22.7 21.7 22.3 22.3 8.0 Transport systems

All the raw materials and finished products are transported by road. Dedicated parking

facility is provided for transport vehicles. The plant is located in an industrial area, and there

will not be any unauthorized shop or settlements along the road connecting the plant site.

There will be 10-12 truck trips per day to the factory. Traffic signs are placed in the battery

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limit. The drivers of the vehicles will be provided with TREM cards and will be explained the

measure to be adopted during various emergencies.

9.0 Reduce, Recovery and Reuse (Terms of Reference No. 7(vii)

It is the endeavor of the project authorities to increase the yields of the products through

constant research and development activity. The development activity shall concentrate on

increasing the yields, using less quantity of raw material, using alternative solvents with low

hazards adopting green chemistry principles. The solvents shall be recycled for reuse in the

process by distillation. The mother liquors from the first crop shall be reused for process.

The cleaning cycles will be reduced by adopting appropriate production plan with minimum

changeovers of the product. Hydro jets or high pressure cleaning shall be adopted for

washing the reactors to minimize washing effluents. It is proposed to use third and fourth

washing water for first and second washing of the reactor and centrifuges. The steam

condensate shall be reused for boiler feed. Treated effluent is reused for cooling tower

makeup, while boiler blow down is reused for scrubbing. A cross functional team shall

constantly evaluate various options of reduce, reuse and recycle for water conservation,

reduction in wastewater generation, effluent segregation, reuse of wastes, alternate treatment

methods, leakage/spillage control, avoidance of overflow and contamination. As part of the

above exercise the proponent identified few compounds which can be recovered as

byproducts and sold. It is also proposed to explore recovery of various salts from MEE salts,

and from process effluents to reduce effluent loads, and quantity of solid waste.

10.0 Energy Conservation

It is proposed to use screw compressors (Air/Refrigeration) for energy efficiency (10 – 12%

saving), evaporative condensers in the chilling circuit to reduce overall power, Cooling tower

fan control to switch off at times not required (Low temp), energy efficient pumps to conserve

energy.

11.0 Green Belt Development (Terms of Reference No. 7(ix)

The Hazelo Lab Pvt. Ltd., is an existing chemical plant. Green belt is developed in an area of

1.8 acres, it is proposed to enhance the green belt area to 11.5 acres, covering the boundary of

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the site as part of environment management plan. It has taken adequate measures for

prevention and control of pollution. It has a fully fledged Environment monitoring

management cell. Ggreenbelt plan presented in Fig. 1.5

Green Belt Photographs

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SCALE 1Cm = 00 mtrs

PROD UCTION BLOCK40.0x12.5

PROPOSED BLOCK40.0x19.0

40.0x12.5

8.0X12.5MRO AD 5.0 M

DCPRO POSED

14.0X12.5MTANKS

RO AD 5.0 M

R OAD 7.0 M

SOLV ENT YARD45.3x60.0

LRM -II

40.0x20.0

U N LOA DING

PROPOSED B LOCK40.0x19.0

IN TER M EDIATE STORAGE

Q C& QA

PRO PO SED

70.0x19.0

PRO PO SED SERV ICE BLOCK70.0x12.5

R OA D 5.0 M

40.0x20.0

28.0x20.0

40.0x20.0

70.0x20.0

R OAD 5.0 M

40.0x20.0

40.0x20.0

70.0x20.0

RO AD 5.0 M 25.0x12.5BO ILER20.0x12.5

COAL SHED

PROPOSED B LOCKPROPOSED BLOCK

W AREH OU SE-I

LRM -I

50.0x20.0

40.0x20.0

W AR EHO U SE-II

CANTEEN &C HAN GE ROOM S

PROPOSED BLOCK

PRO PO SED PILO T PLANT

10.0x10.0

TEM PLE

FUTURE

FUTURE

FUTURE

ZLD System

FUTURE FUTURE

FUTUREFUTURE

FUTURE

STORM W ATERPOND

Fig 1.5 Green Belt Development of Hazelo Lab Pvt. Ltd.

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12.0 Corporate Environmental Responsibility (Terms of Reference No. 9(i)

The broad guidelines of the Environmental Policy are presented below. The environmental

Management System shall have standard operating procedures for various aspects identified

which include infringement/deviation/violation of Environment related statutory

regulations:

Environmental Policy

Ensure that all our activities are carried out to avoid & control all foreseeable risks to

the health and safety of all people involved in the operations.

Protect the natural environment by prevention of pollution.

Optimize the use of resources through reduction, reuse, recycling, continuous research

and using efficient technologies.

Comply with all applicable Health, safety & Environment laws, regulations and other

requirements applicable our business.

Continually evaluate and improve the processes by setting the objective in the

direction to minimize hazards & environmental impacts arising out of operations.

Provide safe working environment to everyone in our premises with necessary

infrastructure.

Inculcate Health, safety & Environment awareness across the organization through

recognition, training and development.

Seek involvement of our employees and all stake holders in improving the operations

to ensure clean environment, safety & healthy work place for all.

We are dedicated to the continual improvement of the Health, safety & Environment

performance across our operations. We are of the firm belief that all our employees identify

and share this commitment, which would go a long way in earning the confidence of our

customers, stakeholders and the society.

13.0 Environment Management Cell (Terms of Reference No. 9(iii)& 9(iv))

Vice President – EHS will take the final responsibility for environmental management and

control. The Environmental Manager and staff will supervise the day-to-day activities of the

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environmental management and control. The organ gram of the Environment management

cell is presented in Fig 1.8.

Sr. G. M. Operations

Dy. Manager‐EH&S

Executive‐Environment

Jr. Chemist‐Safety

Sr. Technician‐Environment

Jr. Supervisor Environment

Jr. Chemist  ‐Environment

G.M. CEHS

VICE PRESIDENT

Fig 1.6 Organ gram of the Environment Management Cell

Records shall be maintained for the analysis of raw effluents and treated effluents, ambient

air quality data, stack emissions monitoring results, micro- meteorological data and noise

levels. These records are not only required for the perusal of the pollution control board

authorities but also to derive at the efficiencies of the pollution control equipment as the

objective of the project proponent is not only compliance with statutory regulations, but also

a serious commitment towards clean environment.

The industry shall be regularly maintaining the records as per the hazardous waste

regulations and EPA regulations and is applying for the annual consents for air and water,

and renewal of authorization for the storage of hazardous waste.

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14.0 CREP Guideline and Compliance

CREP Guideline Compliance Segregation of waste streams Segregation of waste streams at source Detoxification and treatment of high COD waste streams

High COD waste streams are neutralized and detoxified as present practice

Management of solid waste Hazardous waste is sent to CHWTSDF. Minimum scale of production to afford cost of pollution control

Production capacities optimized.

Long term strategies for reduction in waste Reduction of waste generation by increasing the yields is a major R&D activity.

Control of air pollution Scrubbers provided to all vents and air emission of reactions apart from Bag filter to boilers.

Self – regulation by industry through regular monitoring and environmental auditing

Third party monitoring conducted quarterly

Optimizing the inventory of hazardous chemicals

Storage of chemicals optimized for one week.

15.0 Other Management Practices

The industry will maintain records as per the hazardous waste regulations and EPA

regulations and apply for the annual consents for air and water, and renewal of

authorization for the storage of hazardous waste as per Hazardous Waste (Handling &

Management) Rules, 1989 and subsequent amendments. The records of hazardous waste

manifest will be maintained.

The industry shall obtain the consent for operation (CFO) as required under section 25/26 of

the Water Act, 1974 and under section 21/22 of Air Act, 1981 before trial production and

commissioning from the Sate Pollution Control Board. The CFO will be renewed each year

by the industry. The industry will obtain the necessary permissions under Hazardous Waste

(Management and Handling) Rules 1989, and Manufacture, Storage and Import of

Hazardous Chemicals Rules, 1989, issued by the Ministry of Environment and Forests, New

Delhi. The industry will submit environmental statement every year before September 30,

and monthly water cess returns. The management ensures that it will comply with all the

directions and regulations issued by the Ministry of Environment and Forests, New Delhi,

State and Central Pollution Control Boards. The Consent for Establishment, Consent for

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Operation will be displayed in a conspicuous location for the information of the inspecting

authorities of different departments.

16.0 Cost Estimate for Environment Management Plan (Terms of Reference No. 7(xi)

It is estimated that the total capital cost for implementing the Environment Management

plan is Rs. 1204.3 Lakhs, while the recurring costs for the same is Rs. 1593 Lakhs/year. The

cost estimate is presented in Table 1.16. The item wise tentative capital cost estimate for

environment management measures is presented in Table 1.17

Table 1.16 Environmental Management Cost estimate S.No Description Capital Recurring Cost

1 Air pollution Control 392 55 2 Water pollution Control 682 1045 3 Noise pollution Control 9 2 4 Environment Monitoring and Management 20 9 5 Occupational Health 28.3 12 6 Green Belt 18 4 7 Others (S. Waste) 55 466

Total (Lakhs) 1204.3 1593 Note: Value in Rs. Lakhs

Table 1.17 Item Wise Tentative Capital Cost Estimate for Environment Management S.No Description Cost

(Rs. Lakhs) I Air pollution Bag Filter 70 Scrubbers 90 Condensors 72 Vaccum pumps 105 Spill control kits 0.48 Closed Hoods and AOD pumps 7.5 Dust Collectos 12 Coal handling system 15 Ash handling system 20 Total - I 392 II Safety Breather Valves 1 Rupture disks 1.4 Trolleys 0.2 Fire hydrant system 1 Gas detection system 3 Safety releif valves 3.75

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Fire extinguishers 1 Fire buckets 0.08 Total - II 11.43

III Occupational safety Ocuupational safety and health centre with facilities 6 Self contained breathing apparatus 3.36 Personal protective equipment 5 Eye wash and body wash showers 2.5 Total - III 16.86

IV Water Effluent treatment system 600 Storm water drains 15 Storm water storage tank 30 Rain water harvesting structures 8 Fire hydrant storage tank 4 Effluent and sewage transfer lines 25 Total - IV 682 V Noise Acoustic enclosures 4 Guards, casing, attenuating screens 2.5 Vibration control pads 1.5 Others 1 Total - V 9

VI Solid waste Storage area for hazardous waste 40 Detoxification area 6 Ash handling system 9 Total - VI 55

VII Green Belt 18 Total - VIII 18

VIII Environmental monitoring Laboratory 15 Monitoring equipment 5 Total - VIII 20 Total (I+II+III+IV+V+VI+VII+VIII) 1204.3

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HAZELO LAB PVT. LTD. SY.NO. 240, 242, 243, 247, 248 AND 249, DOTHIGUDEM VILLAGE, POCHAMPALLY MANDAL, YADRADI BHUVANAGIRI DISTRICT, 

TELANGANA  

        

3. COMPLIANCE OF TERMS OF REFERENCE 

       

   

Project No. 0317‐21‐01March 2017 

 

Hazelo Lab Pvt. Ltd. Hetero Corporate Office, 7‐2‐A2, Industrial Estate Sanath Nagar, Hyderabad,  Telanagana – 500 018 Phone: 08455‐233585  Fax: 08455‐233840   E‐mail: [email protected] 

STUDIES AND DOCUMENTATION BYTEAM Labs and Consultants B‐115‐117 & 509, Annapurna Block, Aditya Enclave, Ameerpet,  Hyderabad‐500 038. Phone: 040‐23748 555/23748616, Telefax: 040‐23748666      

 

SUBMITTED TO TELANGANA STATE POLLUTION CONTROL BOARD,  

REGIONAL OFFICE, NALGONDA

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Compliance of Terms of Reference Compliance of Standard TOR for “Synthetic Organic Chemicals Industry (dyes and dye

intermediates; bulk drugs and intermediates excluding drug formation; synthetic rubber; basic organic chemicals, other synthetic organic chemicals and chemical intermediates” Issued by

MoEF&CC for EIA/EMP report for Projects/Activates requiring Environmental Clearance Under EIA Notification, 2006

TOR Letter No. J-11011/19/2016-IA II (I) Date: 31.03.2016

S.No Compliance of Terms or Reference Response A. STANDARD TERMS OF REFERENCE

1 Executive Summary Included in EIA report. 2 Introduction i. Details of the EIA Consultant including

NABET accreditation EIA Consultants: Team Labs and Consultants List of QCI/NABET Consultants: S.No.147 (Rev. 51 - March 07, 2017)

ii. Information about the project proponent Presented in Chapter 1 of EIA report at Page No. 1-1

iii. Importance and benefits of the project Presented in Chapter 1 of EIA report at Page No. 1-1

3 Project Description i. Cost of project and time of completion. Cost of Project for Proposed Expansion

is 45 crores. ii. Products with capacities for the proposed

project. Presented in Chapter 1 of EIA report at Page No. 1-3 to 1-5

iii. If expansion project, details of existing products with capacities and whether adequate land is available for expansion, reference of earlier EC if any.

Presented in Chapter 1 of EIA report at Page No. 1-3 to 1-5. Additional land acquired for proposed expansion is 29.16 acres in addition to existing site area of 4.325 acres. Total land area after expansion is 33.485 acres.

iv. List of raw materials required and their source along with mode of transportation.

Presented in Chapter 6 of EIA report at Page No. 6-5

v. Other chemicals and materials required with quantities and storage capacities

Presented in Chapter 6 of EIA report at Page No. 6-5

vi. Details of Emission, effluents, hazardous waste generation and their management.

Presented in Environment Management Plan. Effluents: 1-4 to 1-12 Emissions: 1-13 to 1-20 Hazardous Waste: 1-21 to 1-22.

vii. Requirement of water, power, with source of supply, status of approval, water balance diagram, man-power requirement (regular and contract)

Total water required after expansion: 468.3 KLD Fresh water: 298.27 KLD Recycled water: 170 KLD Detailed water balance is presented in Chapter 2 of EIA Report at Page No. 2-100

viii. Process description along with major Presented in 2 of EIA Report at Page

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equipments and machineries, process flow sheet (quantative) from raw material to products to be provided

No. 2-3 to 2-99

ix. Hazard identification and details of proposed safety systems.

Presented in Chapter 6 of EIA report at Page No. 6-13 to 6-16.

x. Expansion/modernization proposals: a. Copy of all the Environmental Clearance(s)

including Amendments thereto obtained for the project from MOEF/SEIAA shall be attached as an Annexure. A certified copy of the latest Monitoring Report of the Regional Office of the Ministry of Environment and Forests as per circular dated 30th May, 2012 on the status of compliance of conditions stipulated in all the existing environmental clearances including Amendments shall be provided. In addition, status of compliance of Consent to Operate for the ongoing existing operation of the project from SPCB shall be attached with the EIA-EMP report.

Not Applicable

b. In case the existing project has not obtained environmental clearance, reasons for not taking EC under the provisions of the EIA Notification 1994 and/or EIA Notification 2006 shall be provided. Copies of Consent to Establish/No Objection Certificate and Consent to Operate (in case of units operating prior to EIA Notification 2006, CTE and CTO of FY 2005-2006) obtained from the SPCB shall be submitted. Further, compliance report to the conditions of consents from the SPCB shall be submitted.

M/s. Hazelo Lab Pvt. Ltd., (formerly known as Venlar Labs ( P ) Ltd., was established before 2006 EIA notification and involved in manufacturing of API intermediates. The unit had renewed consent and HW authorization (CFO) vide Letter No. TSPCB/RCP/NLG/16644/HO/2015-986 dated 14.08.2015 valid till 31.01.2018.

4 Site Details i. Location of the project site covering village,

Taluka/Tehsil, District and State, Justification for selecting the site, whether other sites were considered.

Hazelo Lab Pvt. Ltd . Sy.Nos. 240, 242, 243, 247, 248 and 249, Dothigudem Village, Pochampally Mandal, Yadadri Bhuvanagiri district, Telangana State. The proposal is for expansion of existing unit by acquiring additional land. Additional land acquired for proposed expansion is 29.16 acres in addition to existing site area of 4.325 acres. Total land area after expansion is 33.485 acres.

ii. A topo sheet of the study area of radius of 10km and site location on 1:50,000/1:25,000 scale on an A3/A2 sheet. (including all eco-

Presented in Chapter 1 of EIA report at Page No. 1-6.

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sensitive areas and environmentally sensitive places)

iii. Details w.r.t. option analysis for selection of site

Proposal is for expansion of existing plant site.

iv. Co-ordinates (lat-long) of all four corners of the site.

S.No Latitude Longitude 1 17O17’14.53” 78O50’42.5” 2 17O17’23.19” 78O50’42.9” 3 17O17’23.47” 78O50’52.17” 4 17O17’29.5” 78O50’53.84” 5 17O17’28.3” 78O50’57.95” 6 17O17’18.24” 78O50’54.81” 7 17O17’25.92” 78O51’02.9” 8 17O17’23.81” 78O51’00.9” 9 17O17’23.89” 78O50’58.83”

10 17O17’21.33” 78O50’58.51” 11 17O17’21.44” 78O50’56.51” 12 17O17’18.56” 78O50’56.79” 13 17O17’13.67” 78O50’54.55”

v. Google map-Earth downloaded of the project site.

Enclosed at Annexure - I

vi. Layout maps indicating existing unit as well as proposed unit indicating storage area, plant area, greenbelt area, utilities etc. If located within an Industrial area/Estate/Complex, layout of Industrial Area indicating location of unit within the Industrial area/Estate.

Plant layout is presented in Chapter 1 of EIA report at Page No. 1-9

vii. Photographs of the proposed and existing (if applicable) plant site. If existing, show Photographs of plantation/greenbelt, in particular.

Photographs of Plant site is presented in Chapter 3 of EIA report at Page No. 3-2

viii. Land use break-up of total land of the project site (identified and acquired), government/ private - agricultural, forest, wasteland, water bodies, settlements, etc shall be included. (not required for industrial area)

Plant layout is presented in Chapter 1 of EIA report at Page No. 1-9

ix. A list of major industries with name and type within study area (10km radius) shall be Incorporated. Land use details of the study area

Land use and Land Cover map of the study area is presented in Chapter 3 of EIA report at Page No. 3-7.

x. Geological features and Geo-hydrological status of the study area shall be included.

Presented in Chapter 3 of EIA report at Page No. 3-3 to 3-4

xi. Details of Drainage of the project upto 5km radius of study area. If the site is within 1 km radius of any major river, peak and lean season river discharge as well as flood occurrence Frequency based on peak rainfall data of the past 30 years. Details of Flood Level of the Project site and maximum Flood Level of the river shall also be provided. (mega green field projects)

Drainage pattern of the impact area is presented in Chapter 3 of EIA report at Page No. 3-14

xii. Status of acquisition of land. If acquisition is not complete, stage of the acquisition process

The proposal is for expansion of existing unit by acquiring additional

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and expected time of complete possession of the land.

land. Additional land acquired for proposed expansion is 29.16 acres in addition to existing site area of 4.325 acres. Total land area after expansion is 33.485 acres.

xiii. R&R details in respect of land in line with state Government policy.

Not Applicable. Expansion within existing site area.

5 Forest and wildlife related issues (if applicable): i. Permission and approval for the use of forest

land (forestry clearance), if any, and recommendations of the State Forest Department. (if applicable)

Not Applicable

ii. Land use map based on High resolution satellite imagery (GPS) of the proposed site delineating the forestland (in case of projects involving forest land more than 40 ha)

The proposal is for expansion of existing unit by acquiring additional land, however land use map is presented in Chapter 3 of EIA report at Page No. 3-7

iii. Status of Application submitted for obtaining the stage I forestry clearance along with latest status shall be submitted.

Not Applicable

iv. The projects to be located within 10 km of the National Parks, Sanctuaries, Biosphere Reserves, Migratory Corridors of Wild Animals, the project proponent shall submit the map duly authenticated by Chief Wildlife Warden showing these features vis-à-vis the project location and the recommendations or comments of the Chief Wildlife Warden-thereon.

There are no National Parks, Sanctuaries, Biosphere Reserves, Migratory Corridors of Wild Animals within the impact area of 10 km.

v. Wildlife Conservation Plan duly authenticated by the Chief Wildlife Warden of the State Government for conservation of Schedule I fauna, if any exists in the study area.

Not Applicable

vi. Copy of application submitted for clearance under the Wildlife (Protection) Act, 1972, to the Standing Committee of the National Board for Wildlife.

Not Applicable

6 Environmental Status i. Determination of atmospheric inversion level at

the project site and site-specific micrometeorological data using temperature, relative humidity, hourly wind speed and direction and rainfall.

Site-specific micrometeorological data presented in Chapter 3 of EIA report at Page No. 3-22 to 3-24

ii. AAQ data (except monsoon) at 8 locations for PM10, PM2.5, SO2, NOX, CO and other parameters relevant to the project shall be collected. The monitoring stations shall be based CPCB guidelines and take into account the pre-dominant wind direction, population zone and sensitive receptors including reserved

AAQ data presented in Chapter 3 of EIA report at Page No. 3-29 to 3-30

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forests. iii. Raw data of all AAQ measurement for 12

weeks of all stations as per frequency given in the NAQQM Notification of Nov. 2009 along with - min., max., average and 98% values for each of the AAQ parameters from data of all AAQ stations should be provided as an annexure to the EIA Report.

AAQ data is presented in Chapter 3 of EIA report at Page No. 3-29 to 3-30.

iv. Surface water quality of nearby River (100m upstream and downstream of discharge point) and other surface drains at eight locations as per CPCB/MoEF&CC guidelines.

Surface water quality is presented in Chapter 3 of EIA report at Page No. 3-12.

v. Whether the site falls near to polluted stretch of river identified by the CPCB/MoEF&CC, if yes give details.

No.

vi. Ground water monitoring at minimum at 8

locations shall be included. Ground Monitoring locations presented in Chapter 3 of EIA report at Page No. 3-13 to 3-18.

vii. Noise levels monitoring at 8 locations within the study area.

Noise levels monitoring is presented in Chapter 3 of EIA report at Page No. 3-30 to 3-32

viii. Soil Characteristic as per CPCB guidelines. Soil Characteristics is presented in Chapter 3 of EIA report at Page No. 3-9

ix. Traffic study of the area, type of vehicles, frequency of vehicles for transportation of materials, additional traffic due to proposed project, parking arrangement etc.

The additional traffic generated due to the proposed expansion shall be 10 - 12 truck trips per day.

x. Detailed description of flora and fauna (terrestrial and aquatic) existing in the study area shall be given with special reference to rare, endemic and endangered species. If Schedule-I fauna are found within the study area, a Wildlife Conservation Plan shall be prepared and furnished.

Flora and Fauna of the Impact area is presented in Chapter 3 of EIA report at Page No. 3-39 to 3-49.

xi. Socio-economic status of the study area. Socio-Economic status of the impact area is presented in Chapter 3 of EIA report at Page No. 3-33 to 3-38

7 Impact and Environment Management Plan i. Assessment of ground level concentration of

pollutants from the stack emission based on site-specific meteorological features. In case the project is located on a hilly terrain, the AQIP Modelling shall be done using inputs of the specific terrain characteristics for determining the potential impacts of the project on the AAQ. Cumulative impact of all sources of emissions (including transportation) on the AAQ of the area shall be assessed. Details of the model used and the input data used for modelling shall also be provided. The air quality contours shall be plotted on a location

Predictions of ground level concentrations using ISC-AERMOD using ISCST3 model is of the pollutants presented in Chapter 4 of EIA report at Page No. 4-16 to 4-24. There will be 10 - 12 truck trips per day after expansion. Emissions considered from transport of vehicles as line source.

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map showing the location of project site, habitation nearby, sensitive receptors, if any.

ii. Water Quality modelling - in case of discharge in water body

Not applicable Total effluent generated sent to “Zero Liquid Discharge“System

iii. Impact of the transport of the raw materials and end products on the surrounding environment shall be assessed and provided. In this regard, options for transport of raw materials and finished products and wastes (large quantities) by rail or rail-cum road transport or conveyor cum- rail transport shall be examined.

There will be 10 - 12 truck trips per day. Truck transport Incidents and concerns are presented in Chapter 6 of EIA report at Page No. 6-43.

iv. A note on treatment of wastewater from different plant operations, extent recycled and reused for different purposes shall be included. Complete scheme of effluent treatment. Characteristics of untreated and treated effluent to meet the prescribed standards of discharge under E (P) Rules.

Quantity, quality of effluent generated from different operation is presented in Environment Management Plan of EIA report at Page No. 1-4.

Effluent Treatment System (ZLD) is presented in Environment Management Plan of EIA report at Page No. 1-6 to 1-12.

v. Details of stack emission and action plan for control of emissions to meet standards.

Presented in Environment Management Plan of EIA report at Page No. 1-13.

vi. Measures for fugitive emission control Presented in Environment Management Plan of EIA report at Page No. 1-18.

vii. Details of hazardous waste generation and their storage, utilization and management. Copies of MOU regarding utilization of solid and hazardous waste in cement plant shall also be included. EMP shall include the concept of waste-minimization, recycle/reuse/recover Techniques, Energy conservation, and natural resource conservation.

Presented in Environment Management Plan of EIA report at Page No. 1-21 to 1-22. Reduce, reuse and recycled concept is presented in waste-minimization, Energy conservation is presented in Environment Management Plan of EIA report at Page No. 1-32.

viii. Proper utilization of fly ash shall be ensured as per Fly Ash Notification, 2009. A detailed plan of action shall be provided.

Ash generated from boiler send to brick manufactureres.

ix. Action plan for the green belt development plan in 33 % area i.e. land with not less than 1,500 trees per ha. Giving details of species, width of plantation, planning schedule etc. shall be included. The green belt shall be around the project boundary and a scheme for greening of the roads used for the project shall also be incorporated.

11.5 acres allocated for green area. Layout showing green belt development is presented in Environment Management Plan at Page No. 1-33 to 1-34.

x. Action plan for rainwater harvesting measures at plant site shall be submitted to harvest rainwater from the roof tops and storm water drains to recharge the ground water and also

Presented in Environment Management Plan of EIA report at Page No. 1-23 to 1-25.

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to use for the various activities at the project site to conserve fresh water and reduce the water requirement from other sources.

xi. Total capital cost and recurring cost/annum for environmental pollution control measures shall be included.

Total Capital Cost: Rs. 45 crores EMP Cost estimate: Rs. 12.04 crores Recurring Cost on EMP: Rs. 15.93 crores /annum. Details are presented in Environment Management Plan at Page no. 1-38.

xii. Action plan for post-project environmental monitoring shall be submitted.

Presented in Chapter 5 of EIA report at Page No. 5-8.

xiii. Onsite and Offsite Disaster (natural and Man-made) Preparedness and Emergency Management Plan including Risk Assessment and damage control. Disaster management plan should be linked with District Disaster Management Plan.

Disaster Management Plan is presented in Chapter 6 of EIA report at Page No.6-47.

Onsite and Offsite Disaster is presented in Chapter 6 of EIA report at Page No.6-48.

8 Occupational Health i. Plan and fund allocation to ensure the

occupational health & safety of all contract and casual workers

Total: 80 Lakhs/annum PPE: 60 Lakhs/annum Health Check-up: 20 Lakhs/annum

ii. Details of exposure specific health status evaluation of worker. If the workers' health is being evaluated by pre designed format, chest x rays, Audiometry, Spirometry, Vision testing (Far & Near vision, colour vision and any other ocular defect) ECG, during pre placement and Periodical examinations give the details of the same. Details regarding last month analyzed data of above mentioned parameters as per age, sex, duration of exposure and department wise.

Medical health check-up is Environment Management Plan of EIA report at Page No. 1-27 to 128.

iii. Details of existing Occupational & Safety Hazards. What are the exposure levels of hazards and whether they are within Permissible Exposure level (PEL). If these are not within PEL, what measures the company has adopted to keep them within PEL so that health of the workers can be preserved,

Presented in Environment Management Plan of EIA report at Page No. 1-26 to 1-27.

Suitable PPE is prescribed to the employees working in area where the conc. Exceeds PEL values. Simultaneously the project and R&D team are consulted to suggest mitigative measures and or engineering control measures.

The focus shall always be in ensuring concentration within PEL by adopting engineering controls as when requires.

iv. Annual report of heath status of workers with special reference to Occupational Health and Safety.

Annual report of Health Status of workers will maintained

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9 Corporate Environment Policy i. Does the company have a well laid down

Environment Policy approved by its Board of Directors? If so, it may be detailed in the EIA report.

Corporate Environment Policy is presented in Environment Management Plan of EIA report at Page No. 1-35.

ii. Does the Environment Policy prescribe for standard operating process / procedures to bring into focus any infringement / deviation / violation of the environmental or forest norms / conditions? If so, it may be detailed in the EIA.

Environment engineer is responsible to bring to focus to higher management in case of deviation/ violation of the environmental or forest norms / conditions.

iii. What is the hierarchical system or Administrative order of the company to deal with the environmental issues and for ensuring compliance with the environmental clearance Conditions? Details of this system may be given.

Environment Management Cell is presented in Environment Management Plan of EIA report at Page No. 1-35.

iv. Does the company have system of reporting of non compliances / violations of environmental norms to the Board of Directors of the company and / or shareholders or stakeholders at large? This reporting mechanism shall be detailed in the EIA report

Yes. Environment Management Cell is presented in Environment Management Plan of EIA report at Page No. 1-35.

10 Details regarding infrastructure facilities such as sanitation, fuel, restroom etc. to be provided to the labour force during construction as well as to the casual workers including truck drivers during operation phase.

Presented in Environment Management Plan of EIA report at Page No. 1-2.

11 Enterprise Social Commitment (ESC) i. Adequate funds (at least 2.5 % of the project

cost) shall be earmarked towards the Enterprise Social Commitment based on Public Hearing issues and item-wise details along with time bound action plan shall be included. Socio-economic development activities need to be elaborated upon.

Corporate Social Responsibilities – Budget is presented in Environment Management Plan of EIA report at Page No. 1-30 to 1-31.

12 Any litigation pending against the project and/or any direction/order passed by any Court of Law against the project, if so, details thereof shall also be included. Has the unit received any notice under the Section 5 of Environment (Protection) Act, 1986 or relevant Sections of Air and Water Acts? If so, details thereof and compliance/ATR to the notice(s) and present status of the case.

No Individual Court case against the Project.

13 A tabular chart with index for point wise compliance of above TOR.

Enclosed at Compliance of Terms of Reference along with EIA & EMP.

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B. SPECIFIC TERMS OF REFERENCE FOR EIA STUDIES FOR SYNTHETIC ORGANIC CHEMICALS INDUSTRY (DYES & DYE INTERMEDIATES; BULK DRUGS AND INTERMEDIATES EXCLUDING DRUG FORMULATIONS; SYNTHETIC RUBBERS; BASIC ORGANIC CHEMICALS, OTHER SYNTHETIC ORGANIC CHEMICALS AND CHEMICAL INTERMEDIATES)

1 Details on solvents to be used, measures for solvent recovery and for emissions control.

Details of solvents used and balance is presented in Chapter 2 of EIA report at Page No. 2-121 to 2-129.

2 Details of process emissions from the proposed unit and its arrangement to control.

Details of process emissions is presented in Chapter 2 of EIA report at Page No. 2-118 to 2-120

3 Ambient air quality data should include VOC, other process-specific pollutants* like NH3*, chlorine*, HCl*, HBr*, H2S*, HF*,etc., (*-as applicable)

AAQ data is presented in Chapter 3 of EIA report at Page No. 3-29

4 Work zone monitoring arrangements for hazardous chemicals.

Presented in Chapter 5 of EIA report at Page No. 5-10.

5 Detailed effluent treatment scheme including segregation of effluent streams for units adopting 'Zero' liquid discharge.

Details of Effluent Treatment System (ZLD) are presented in Environment Management Plan of EIA report at Page No. 1-6 to 1-12.

6 Action plan for odour control to be submitted. Presented in Environment Management Plan of EIA report at Page No. 1-18.

7 A copy of the Memorandum of Understanding signed with cement manufacturers indicating clearly that they co-process organic solid/hazardous waste generated.

Enclosed at Annexure

8 Authorization/Membership for the disposal of liquid effluent in CETP and solid/hazardous waste in TSDF, if any.

Enclosed at Annexure

9 Action plan for utilization of MEE/dryers salts. Salts generated from MEE/ATFD sent to TSDF.

10 Material Safety Data Sheet for all the Chemicals are being used/will be used.

Enclosed at Annexure

11 Authorization/Membership for the disposal of solid/hazardous waste in TSDF.

Enclosed at Annexure

12 Details of incinerator if to be installed. Not Applicable. Organic waste sent to cements plant for co-incineration.

13 Risk assessment for storage and handling of hazardous chemicals/solvents. Action plan for handling & safety system to be incorporated.

Presented in Chapter 6 of EIA report at Page No.6-32 to 6-39.

14 Arrangements for ensuring health and safety of workers engaged in handling of toxic materials.

Presented in Chapter 6 of EIA report at Page No.6-412 to 6-43.

B. ADDITIONAL TOR 1 Public hearing to be conducted and issues raised and

commitments made by the project proponent on the same should be included in EIA/EMP report in the form of tabular chart with financial budget for complying with the commitments made.

2 A copy of compliance report to the Environmental M/s. Velar Labs Pvt. Ltd., obtained

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conditions prescribed in the existing EC. Action taken report/ detailed action plan on the partly/non-compliance conditions reported by the MoEF&CC Regional Office.

Environment Clearance for Modernization of Synthetic Organic Chemicals vide order No. F. No. 11011/87/2010 - IA II (I) dated 23.11.2010 for change of product mix, which was not implemented.

3 Existing EC required to be changed in the name from M/s. Venlar Labs Pvt. Ltd to M/s. Hazelo Lab Pvt. Ltd.

Not Applicable. Velar Labs Pvt. Ltd., obtained Environment Clearance for Modernization of Synthetic Organic Chemicals vide order No. F. No. 11011/87/2010 - IA II (I) dated 23.11.2010 for change of product mix, which was not implemented

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HAZELO LAB PVT. LTD. SY.NO. 240, 242, 243, 247, 248 AND 249, DOTHIGUDEM VILLAGE, POCHAMPALLY MANDAL, YADRADI BHUVANAGIRI DISTRICT, 

TELANGANA   

        

4. ANNEXURES 

         

    

Project No. 0317‐21‐01March 2017 

 

Hazelo Lab Pvt. Ltd. Hetero Corporate Office, 7‐2‐A2, Industrial Estate Sanath Nagar, Hyderabad,  Telanagana – 500 018 Phone: 08455‐233585  Fax: 08455‐233840   E‐mail: [email protected] 

STUDIES AND DOCUMENTATION BY TEAM Labs and Consultants B‐115‐117 & 509, Annapurna Block, Aditya Enclave, Ameerpet,  Hyderabad‐500 038. Phone: 040‐23748 555/23748616, Telefax: 040‐23748666      

 

SUBMITTED TO TELANGANA STATE POLLUTION CONTROL BOARD,  

REGIONAL OFFICE, NALGONDA 

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HAZELO LAB PVT. LTD. SY.NO. 240, 242, 243, 247, 248 AND 249, DOTHIGUDEM VILLAGE, POCHAMPALLY MANDAL, YADRADI BHUVANAGIRI DISTRICT, 

TELANGANA   

      

POINT WISE COMPLIANCE OF CONSENT FOR OPERATION 

 

    

   Project No. 0317‐21‐01 March 2017 

 

Hazelo Lab Pvt. Ltd. Hetero Corporate Office, 7‐2‐A2, Industrial Estate Sanath Nagar, Hyderabad,  Telanagana – 500 018 Phone: 08455‐233585  Fax: 08455‐233840   E‐mail: [email protected] 

STUDIES AND DOCUMENTATION BY TEAM Labs and Consultants B‐115‐117 & 509, Annapurna Block, Aditya Enclave, Ameerpet,  Hyderabad‐500 038. Phone: 040‐23748 555/23748616, Telefax: 040‐23748666      

 

SUBMITTED TO TELANGANA STATE POLLUTION CONTROL BOARD,  

REGIONAL OFFICE, NALGONDA

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M/S. HAZELO LAB PRIVAE LIMITED (Formerly M/s. Velar Labs Private Limited), Dhotigudem, Pochampally(M), Yadadri dist.Consent for Operation condition wise status report vide consent no. TSPCB/RCP/NGL/16644/HO/2015‐986 DT.14/08/2015.

                                                                                                                        SHEDULE‐AS.no CFO Conditions Condition wise status report1 The applicant shall make applications through online for renewal of 

consent (under water and air Acts)and authorization under HWM rules at least 120 days before the date of expiry of this order ,along with prescribed fee under water and air acts for obtaining consent&HW authorization of the board along with detailed compliance to the conditions stipulated in the CFO and HWA order.

Complying with this condition

2 Concealing the factual data or submission of false information/fabricated data and failure to comply with any of the conditions mentioned in this order may result in withdrawal of this order and attract action under the provisions of relevant pollution control acts

Noted

3 Any person aggrieved by an order made by the state board under section 25,section26,section27Of water act,1974 or section 21 of Air Act,1981 may within thirty days from the date on which the order is communicated to him,prefer an appeal as per Andhra Pradesh water rules,1976 and Air rules 1982,to such authority (hereinafter referred to as the appellate Authority)constituted under section 28 of the Water (prevention and conteol of pollution )Act 1974 and section 31 of the Air(Preventation and Control of Pollution)Act,1981

The industry is following all rules and regulations in accordance with Air & Water act rules.

4 The industry may explore the posibility of tapping the solar energy for their enery requirements.

We will explore the possibility of solar energy requirements in the plant premises.

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5 All he conditions stipulated in the shedule ‐A earlier combined CFO &HWA order No.APPCB/RCP/NLG/98/CFO/HO/2012‐4076 Date:12.11.2012 remains same.the industry should ensure consistence complience of each condition of Shedule‐A.

The industry is complying Schedule‐A conditions of CFO & HWA Order dated 12/11/2012.

6 The board reserves its right to modify above conditions or stipulate any further conditions and to take action including revoke of this order in the intrest of protection of public health environment.

Noted

7                                                                                                                                       SCHEDULE‐B8 The industry should take steps to reduce water consumption to the 

extent possible and consumption should not exceed the quantities prescribed below:                               1.process& washings:‐8.06KLD    2.Floor washings:‐1.0KLD                             3.Boiler Feed :‐1.5KLD         4.Cooling tower make up:‐2.0 KLD           5.Domestic:‐1.2 KLD

The industry is consuming water within the limit which is pescribed in the Consent.

9 The industry should file the water cess returns in form ‐I as required under section(5) of water(Prevention and control of pollution)Cess,1977 on or before the 5th of every calander month,showing the quantity of water consumed in the previous month along with water meter readings.The industry should remit water cess as per the assessment orders as and when isssued by board

Complying with this condition

10 The emissions should not contain constituents in excess of the presscribed limits mentioned below:‐  A)chimney 1&2 particulate matter‐Emission standards‐115mg/NM3 B)chimney 3 parameter HCL Acid Vapour&mist Emission Standrds‐35mg/NM3    

The industry is carrying thrid party monitoring and same has been submitting periodically to Regional Office. The emissions are not exceed the parameters as pescribed by the Board.

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11 The industry should comply with emission limits for DG sets of capacity up to 800kw as per the notifiation G.S.R,520(E),dated 01.07.2003 under theenvironment(protection)Amendment rules,2003and G.S.R 448(E) dated 12.07.2004 under the environment protection(protection)second amendment rules,2004.In case of DG sets of capacity more than 800kw should comply with emission limits as per the notification G.S.R 489(E),dated 09.07.2002 at serial no.96, under the environment (protection)Act,1986 

Complying with this condition

12 The industry should comply with ambient air qaulity standards of PM10(particulate Matter sizeless than 10µm)‐100µg/M3;PM2.5(particulate matter size less than 2.5µm)‐60µg/mg3;SO2‐80µg/M3;Nox‐80µg/m3,out side the factory premises at the periphery of the industry.Standards for other parameters as mentioned in the national Ambient Air quality standards CPCB Notification No‐B‐29016/20/90/PCI‐I,dated 18.11.20009     Noise levels: day time(6AM to 10PM)75dB(A)  night time:10PM to 6AM)‐70dB(A)

The ambient air quality and noise level parameter and Noise levels are within the limits  as pescribed in  C.F.O. The industry is carrying third party monitoring periodically and same has been submitting in Regional Office.

13 The idustry shall manifacture only the consented products. Complying with this condition

14 The industry shall not increase the capacity beyond the permitted capacity with out obtaining CFE&CFO of the board

Complying with this condition

15 The industry shall segregate the HTDS&LTDSeffluents The generated entire effluents are treating in Stripper/MEE followed by Nutch filter as High TDS. The quantity of Low TDS effluent generation is very less hence there is no separation.

16 The industry shall regulary operate the existing stripper,multiple effect evaporater(MEE),etc.The Industry shall install the ATFD,Biological ETP,RO plant etc., in a time bound manner to achive ZLD.

Biological ETP,ATFD and RO plant are under installation and complete in time bound manner to acchieve ZLD.

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17 The industry shall send HTDS EFLUENT TO THE MEE system of M/s.JETL,Jeedimetla for a period maximum 15 days in a calander year i.e.,during maintanence /break down of stripper,MEE &ATFD system and shall maintain records. 

Agreed and will be followed

18 The industry can send LTDS effulents to CETP for a priod of Mximum15 days in a calender year i.e,during maintanence /break down of RO system and shall maintain records.

Agreed and will be followed

19 The industry shall not operate the 4TPH coal fired boiler with out obtaining CFE&CFO the Board.

The industry is dismantled  4 TPH coal fired boiler.

20 The industry shall install &operate water for recording category‐wise water consumption

The industry is installed water meters and recording water consumption category‐wise.

21 The industry shall install &operate digital flow meters for inllet of LTDS&HTDS effluents;MEE feed,MEE condensate;steam flow to stripper MEE,RO feed ;RO permeate;RO reject etc

The industry is provided digital flow meters for inlet and out let to meassure the generated quantity of effluents.

22 The industry shall install &operate VOC analyzes for monitoring of VOCs.

The industry is provided VOC analyzer portable mobile hand set to mesure the VOC  analysis.

23 The industry shall install&operate multi stage scrubbers in the plant for control of process emissions.The industry should operate and maintain the scrubbers to scrub pocess emissions.at all emissions sources.THE Details of chemical consumption used in the scrubber should be recorded&kept accessible for the inspection officials of the board.

The industry has provided  multi stage scrubbers in the plant for control of process emissions.

24 The industry shall provide online ph meters for the Multi ‐stage scrubbers.

Provided online pH meters for the multi stage scrubbers.

25 The industry shall provide separate energy meter for the pollution control systems and maintain the records of the same.

The industry has provided energy meter for the pollution control systems and maintaining the records of the same.

26 The industry shall provide vent condensers for all the bulk storage tanks .storing highly voltaile solvents to prevent escaping of fugitive emissions&should maintain the same effectively.

Complying with this condition

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27 The industry shall immediately install&operate IP camera with PAN,TILT Zoom,5x or above focal length with night vision capability.

Complied with this condition

28 the industry shall comply with the directions issued by the task force from time to time

The industry wil follow the all the directions issued by the task force from time to time.

29 The industry should maintain log books on the following.         A.Hydraulic loads of effluent generation                                   B.Characteristics of effluents forced evaporated                                   C.Quantity of effluents forced evaporated                                D.Condensate genaration and reuse                                                     E.Furnish consolidated daily records on the above periadically once in three months to the RO,Nalgonda.

The industry is maintaining all records and same will be available to the board officials when they have to visit the plant.

30 The industry should ensure detoxification in environmentally sound manner of various drums,linerscontainersand other materials that are in contact with bromine compoundsand details should be furnised to the board.

Will be Comply with this condition

31 There should not be any spillages/chemicals/effluents on ground.The drums containing chemicals &wates should be stored on elevated platform with a provision to collect leachate/spillages in the collection pit.In no case drums should be stored on the naked open ground the industry should insure the treatment facilities should be impervious to prevent ground water pollution 

The industry is storing drums containing chemicals & wastes on elevated platform with a provision to collect leachate/spillages in the collection pit to avoide ground water pollution.

32 The industry should insure the treatment facilities should impervious to prevent ground water pollution

The industry is maintaining effective treatment facility to treat the generated effluents in proper way to prevent ground water pollution.

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33 The industry should maintain the consolidated daily records on the following.                                                           A.Effluent generated        B.quantity of treated effluents evaoprated in the forced evaporation system                                                                  C.Quantity of condensate generation    D.Characterstics solidwaste genaration should be submittedto the regional office,Nalgondafor every month.

The industry is maintaining all records and same will be available to the board officials when they have to visit the plant.

34 The industry should maintain the following recordsand the same should be made available to the inspection officer.                                A.Daily production details,RG‐1records and central excise returns.    B.Quantitity of effluents gnerated and forced evaoprated.                   C.Log book for pollution control systems.                                        D.Daily solid waste generatedand disposed to TSDF

The industry is maintaining all records and same will be available to the board officials when they have to visit the plant.

35 Under no circumstances the effluents should be used for land application.

Agreed

36 The industry should maintain records for the consistent performance of solvent recovery system for each stream‐wise and should furnish plan of action to achieve the efficiency of solvent recovery more than 95%for every stream.

Complying with this condition

37 The industry should take all safety measures and provide fire fighting equipment in the plant.

as per safety point of view we arranged all types of fire extingushers,water hydrant system,PRV,SRV rupture disk etc..

38 The industry should not discharge any waste water outside the factory premises and maintain zero discharge of effluents.

The industry is treating the generated effluents in stripper followed by MEE and not discharging outside the factory premises. 

39 Thick green belt should be devolped &maintain by the industry with tall growing tress in the vacant spaces of the unit.

The industry is maintaining  greenary around 45% of palnt occupy

40 The industry sould submit mock drill report carried out at least once in six months as required under the manufacture storage and import of Hazardous chemicals rules,1989

The industry is conducting mock drill to protect the environmenal issues once in six months and same will be submit to Regional Office within week period.

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41 The applicant shall submit environment statement in form V before 30th september of every year as per RuleNo.14 of E(P) Rules,1986&amendments. 

Complying with this condition

42 All the rules &regulations notified by ministry of law and justice,Government of india regarding public liability insurance Act1991,should be followed. 

Noted and agreed

43 The conditions are without prejudice to the rights and contentions of this Board any Hon'blecourt of law

Noted and agreed

                                                                 SECTION‐C44 The industry should give top priority for waste minimization and 

production practiesThe industry has given top priority for minimization of waste and production practies.

45 The industry should not store hazardous waste for more than 90 days a per the hazardous wastes (Management Handling and transboundary Movement)rules,2008and amendments thereof.

Complying with this condition

46 The industry should store used/waste oils and used lead batteries in secured way in their permises till its disposal

Complying with this condition

47 The industry should not dispose waste oils to the traders and the same should be disposed to the authorized reprocessors/Recyclers.

Complying with this condition

48 The industry should disposed used lead acid batteries to manifactures/dealers on buyback basis.

Complying with this condition

49 The industry should not dispose spent solvents/,mixed spent solventsto the traders.

Complying with this condition

50 The industry shoud take necessary practical stepsfor prevention of oil spillages and carry over of oil from the premises.

The industry is taken adequate measures to prevent oil spillages and carry over of oil from the premises.

51 The industry should maintain 6 copy manifest system for transportation of waste generated and a copy should be submitted to board office and concerned regional office 

Complying with this condition

52 The industry should maintain good house keeping &maintain proper records for hazardous wastes stated in authorization.

The industry is maintaining good house keeping and maintaining proper records for hazardous wastes.

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53 The industry should maintain proper records for hazardous wastes stated in authorization in FORM‐ i.e.,quantity of incinerable waste,land disposal waste,recyclable waste etc.,and file annual returns in form‐4 as per rule 22(2) of the Hzardous wastes (Management Handling&Transboundary movement)rules,2008 and amendments thereof.

complying with this condition

54 The industry should submit  the condition wise compliance report of the conditions stipulated in shdule B&C of this order on half yearly basis to board office,hyderabad and concerned regional office.

Complying with this condition

55 The industry should dispose of e‐waste to the authorized recyclers only.

Complying with this condition

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Material Safety Data SheetAcetic acid MSDS

Section 1: Chemical Product and Company Identification

Product Name: Acetic acid

Catalog Codes: SLA3784, SLA1438, SLA2101, SLA3604,SLA1258

CAS#: 64-19-7

RTECS: AF1225000

TSCA: TSCA 8(b) inventory: Acetic acid

CI#: Not applicable.

Synonym: Acetic acid; glacial acetic acid

Chemical Name: Acetic Acid, Glacial

Chemical Formula: C2-H4-O2

Contact Information:

Sciencelab.com, Inc.14025 Smith Rd.Houston, Texas 77396

US Sales: 1-800-901-7247International Sales: 1-281-441-4400

Order Online: ScienceLab.com

CHEMTREC (24HR Emergency Telephone), call:1-800-424-9300

International CHEMTREC, call: 1-703-527-3887

For non-emergency assistance, call: 1-281-441-4400

Section 2: Composition and Information on Ingredients

Composition:

Name CAS # % by Weight

Acetic acid 64-19-7 100

Toxicological Data on Ingredients: Acetic acid: ORAL (LD50): Acute: 3310 mg/kg [Rat]. 4960 mg/kg [Mouse]. 3530 mg/kg[Rat]. DERMAL (LD50): Acute: 1060 mg/kg [Rabbit]. VAPOR (LC50): Acute: 5620 ppm 1 hours [Mouse].

Section 3: Hazards Identification

Potential Acute Health Effects:Very hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation. Hazardous in case of skincontact (corrosive, permeator), of eye contact (corrosive). Liquid or spray mist may produce tissue damage particularly onmucous membranes of eyes, mouth and respiratory tract. Skin contact may produce burns. Inhalation of the spray mist mayproduce severe irritation of respiratory tract, characterized by coughing, choking, or shortness of breath. Inflammation of theeye is characterized by redness, watering, and itching. Skin inflammation is characterized by itching, scaling, reddening, or,occasionally, blistering.

Potential Chronic Health Effects:Hazardous in case of skin contact (irritant), of ingestion, of inhalation. CARCINOGENIC EFFECTS: Not available.MUTAGENIC EFFECTS: Mutagenic for mammalian somatic cells. Mutagenic for bacteria and/or yeast. TERATOGENICEFFECTS: Not available. DEVELOPMENTAL TOXICITY: Not available. The substance may be toxic to kidneys, mucousmembranes, skin, teeth. Repeated or prolonged exposure to the substance can produce target organs damage. Repeated

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p. 2

or prolonged contact with spray mist may produce chronic eye irritation and severe skin irritation. Repeated or prolongedexposure to spray mist may produce respiratory tract irritation leading to frequent attacks of bronchial infection.

Section 4: First Aid Measures

Eye Contact:Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15minutes. Cold water may be used. Get medical attention immediately.

Skin Contact:In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothingand shoes. Cover the irritated skin with an emollient. Cold water may be used.Wash clothing before reuse. Thoroughly cleanshoes before reuse. Get medical attention immediately.

Serious Skin Contact:Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek immediate medicalattention.

Inhalation:If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medicalattention immediately.

Serious Inhalation:Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or waistband. Ifbreathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth resuscitation. WARNING: It maybe hazardous to the person providing aid to give mouth-to-mouth resuscitation when the inhaled material is toxic, infectious orcorrosive. Seek immediate medical attention.

Ingestion:Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconsciousperson. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention if symptoms appear.

Serious Ingestion: Not available.

Section 5: Fire and Explosion Data

Flammability of the Product: Flammable.

Auto-Ignition Temperature: 463°C (865.4°F)

Flash Points: CLOSED CUP: 39°C (102.2°F). OPEN CUP: 43°C (109.4°F).

Flammable Limits: LOWER: 4% UPPER: 19.9%

Products of Combustion: These products are carbon oxides (CO, CO2).

Fire Hazards in Presence of Various Substances:Flammable in presence of open flames and sparks, of heat. Slightly flammable to flammable in presence of oxidizingmaterials, of metals.

Explosion Hazards in Presence of Various Substances:Risks of explosion of the product in presence of mechanical impact: Not available. Risks of explosion of the product inpresence of static discharge: Not available. Slightly explosive in presence of oxidizing materials.

Fire Fighting Media and Instructions:Flammable liquid, soluble or dispersed in water. SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use alcohol foam,water spray or fog. Cool containing vessels with water jet in order to prevent pressure build-up, autoignition or explosion.

Special Remarks on Fire Hazards:Reacts with metals to produces flammable hydrogen gas. It will ignite on contact with potassium-tert-butoxide. A mixture ofammonium nitrate and acetic acid ignites when warmed, especially if warmed.

Special Remarks on Explosion Hazards:

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Acetic acid vapors may form explosive mixtures with air. Reactions between acetic acid and the following materialsare potentially explosive: 5-azidotetrazole, bromine pentafluoride, chromium trioxide, hydrogen peroxide, potassiumpermanganate, sodium peroxide, and phorphorus trichloride. Dilute acetic acid and dilute hydrogen can undergo anexothermic reaction if heated, forming peracetic acid which is explosive at 110 degrees C. Reaction between chlorinetrifluoride and acetic acid is very violent, sometimes explosive.

Section 6: Accidental Release Measures

Small Spill:Dilute with water and mop up, or absorb with an inert dry material and place in an appropriate waste disposal container. Ifnecessary: Neutralize the residue with a dilute solution of sodium carbonate.

Large Spill:Flammable liquid. Corrosive liquid. Keep away from heat. Keep away from sources of ignition. Stop leak if without risk. If theproduct is in its solid form: Use a shovel to put the material into a convenient waste disposal container. If the product is inits liquid form: Absorb with DRY earth, sand or other non-combustible material. Do not get water inside container. Absorbwith an inert material and put the spilled material in an appropriate waste disposal. Do not touch spilled material. Use waterspray curtain to divert vapor drift. Prevent entry into sewers, basements or confined areas; dike if needed. Call for assistanceon disposal. Neutralize the residue with a dilute solution of sodium carbonate. Be careful that the product is not present at aconcentration level above TLV. Check TLV on the MSDS and with local authorities.

Section 7: Handling and Storage

Precautions:\Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not ingest. Do notbreathe gas/fumes/ vapor/spray. Never add water to this product. In case of insufficient ventilation, wear suitable respiratoryequipment. If ingested, seek medical advice immediately and show the container or the label. Avoid contact with skin andeyes. Keep away from incompatibles such as oxidizing agents, reducing agents, metals, acids, alkalis.

Storage:Store in a segregated and approved area. Keep container in a cool, well-ventilated area. Keep container tightly closed andsealed until ready for use. Avoid all possible sources of ignition (spark or flame).

Section 8: Exposure Controls/Personal Protection

Engineering Controls:Provide exhaust ventilation or other engineering controls to keep the airborne concentrations of vapors below their respectivethreshold limit value. Ensure that eyewash stations and safety showers are proximal to the work-station location.

Personal Protection:Splash goggles. Synthetic apron. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Gloves(impervious).

Personal Protection in Case of a Large Spill:Splash goggles. Full suit. Vapor respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoidinhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling thisproduct.

Exposure Limits:TWA: 10 STEL: 15 (ppm) [Australia] TWA: 25 STEL: 27 (mg/m3) [Australia] TWA: 10 STEL: 15 (ppm) from NIOSH TWA: 25STEL: 37 (mg/m3) from NIOSH TWA: 10 STEL: 15 (ppm) [Canada] TWA: 26 STEL: 39 (mg/m3) [Canada] TWA: 25 STEL: 37(mg/m3) TWA: 10 STEL: 15 (ppm) from ACGIH (TLV) [United States] [1999] TWA: 10 (ppm) from OSHA (PEL) [United States]TWA: 25 (mg/m3) from OSHA (PEL) [United States]Consult local authorities for acceptable exposure limits.

Section 9: Physical and Chemical Properties

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Physical state and appearance: Liquid.

Odor: Pungent, vinegar-like, sour (Strong.)

Taste: Vinegar, sour (Strong.)

Molecular Weight: 60.05 g/mole

Color: Colorless. Clear (Light.)

pH (1% soln/water): 2 [Acidic.]

Boiling Point: 118.1°C (244.6°F)

Melting Point: 16.6°C (61.9°F)

Critical Temperature: 321.67°C (611°F)

Specific Gravity: 1.049 (Water = 1)

Vapor Pressure: 1.5 kPa (@ 20°C)

Vapor Density: 2.07 (Air = 1)

Volatility: Not available.

Odor Threshold: 0.48 ppm

Water/Oil Dist. Coeff.: The product is more soluble in water; log(oil/water) = -0.2

Ionicity (in Water): Not available.

Dispersion Properties: See solubility in water, diethyl ether, acetone.

Solubility:Easily soluble in cold water, hot water. Soluble in diethyl ether, acetone. Miscible with Glycerol, alcohol, Benzene, CarbonTetrachloride. Practically insoluble in Carbon Disulfide.

Section 10: Stability and Reactivity Data

Stability: The product is stable.

Instability Temperature: Not available.

Conditions of Instability: Heat, ignition sources, incompatible materials

Incompatibility with various substances: Reactive with oxidizing agents, reducing agents, metals, acids, alkalis.

Corrosivity:Highly corrosive in presence of stainless steel(304). Slightly corrosive in presence of aluminum, of copper. Non-corrosive inpresence of stainless steel(316).

Special Remarks on Reactivity:Reacts violently with strong oxidizing agents, acetaldehyde, and acetic anhydride. Material can react with metals, strongbases, amines, carbonates, hydroxides, phosphates, many oxides,cyanides, sulfides, chromic acid, nitric acid, hydrogenperoxide, carbonates. ammonium nitrate, ammonium thiosulfate, chlorine trifluoride, chlorosulfonic acid, perchloric acid,permanganates, xylene, oleum, potassium hydroxide, sodium hydroxide, phosphorus isocyanate, ethylenediamine, ethyleneimine.

Special Remarks on Corrosivity: Moderate corrosive effect on bronze. No corrosion data on brass

Polymerization: Will not occur.

Section 11: Toxicological Information

Routes of Entry: Absorbed through skin. Dermal contact. Eye contact. Inhalation. Ingestion.

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Toxicity to Animals:WARNING: THE LC50 VALUES HEREUNDER ARE ESTIMATED ON THE BASIS OF A 4-HOUR EXPOSURE. Acute oraltoxicity (LD50): 3310 mg/kg [Rat]. Acute dermal toxicity (LD50): 1060 mg/kg [Rabbit]. Acute toxicity of the vapor (LC50): 56201 hours [Mouse].

Chronic Effects on Humans:MUTAGENIC EFFECTS: Mutagenic for mammalian somatic cells. Mutagenic for bacteria and/or yeast. May cause damage tothe following organs: kidneys, mucous membranes, skin, teeth.

Other Toxic Effects on Humans:Extremely hazardous in case of inhalation (lung corrosive). Very hazardous in case of skin contact (irritant), of ingestion, .Hazardous in case of skin contact (corrosive, permeator), of eye contact (corrosive).

Special Remarks on Toxicity to Animals: Not available.

Special Remarks on Chronic Effects on Humans: May affect genetic material and may cause reproductive effects based onanimal data. No human data found.

Special Remarks on other Toxic Effects on Humans:Acute Potential Health Effects: Skin: Extremely irritating and corrosive. Causes skin irritation (reddening and itching,inflammation). May cause blistering , tissue damage and burns. Eyes: Extremely irritating and corrosive. Causes eye irritation,lacrimation, redness, and pain. May cause burns, blurred vision, conjunctivitis, conjunctival and corneal destruction andpermanent injury. Inhalation: Causes severe respiratory tract irritation. Affects the sense organs (nose, ear, eye, taste),and blood. May cause chemical pneumonitis, bronchitis, and pulmonary edema. Severe exposure may result in lung tissuedamage and corrosion (ulceration) of the mucous membranes. Inhalation may also cause rhinitis, sneezing, coughing,oppressive feeling in the chest or chest pain, dyspnea, wheezing, tachypnea, cyanosis, salivation, nausea, giddiness,muscular weakness. Ingestion: Moderately toxic. Corrosive. Causes gastrointestinal tract irritation (burning and pain of themouth, throat, and abdomen, coughing, ulceration, bleeding, nausea, abdomial spasms, vomiting, hematemesis, diarrhea.May Also affect the liver (impaired liver function), behavior (convulsions, giddines, muscular weakness), and the urinarysystem - kidneys (Hematuria, Albuminuria, Nephrosis, acute renal failure, acute tubular necrosis). May also cause dyspneaor asphyxia. May also lead to shock, coma and death. Chronic Potential Health Effects: Chronic exposure via ingestion maycause blackening or erosion of the teeth and jaw necrosis, pharyngitis, and gastritis. It may also behavior (similar to acuteingestion), and metabolism (weight loss). Chronic exposure via inhalation may cause asthma and/or bronchitis with cough,phlegm, and/or shortness of breath . It may also affect the blood (decreased leukocyte count), and urinary system (kidneys).Repeated or prolonged skin contact may cause thickening, blackening, and cracking of the skin.

Section 12: Ecological Information

Ecotoxicity:Ecotoxicity in water (LC50): 423 mg/l 24 hours [Fish (Goldfish)]. 88 ppm 96 hours [Fish (fathead minnow)]. 75 ppm 96 hours[Fish (bluegill sunfish)]. >100 ppm 96 hours [Daphnia].

BOD5 and COD: BOD-5: 0.34-0.88 g oxygen/g

Products of Biodegradation:Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise.

Toxicity of the Products of Biodegradation: The products of degradation are less toxic than the product itself.

Special Remarks on the Products of Biodegradation: Not available.

Section 13: Disposal Considerations

Waste Disposal:Waste must be disposed of in accordance with federal, state and local environmental control regulations.

Section 14: Transport Information

DOT Classification:

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CLASS 3: Flammable liquid. Class 8: Corrosive material

Identification: : Acetic Acid, Glacial UNNA: 2789 PG: II

Special Provisions for Transport: Not available.

Section 15: Other Regulatory Information

Federal and State Regulations:New York release reporting list: Acetic acid Rhode Island RTK hazardous substances: Acetic acid Pennsylvania RTK: Aceticacid Florida: Acetic acid Minnesota: Acetic acid Massachusetts RTK: Acetic acid New Jersey: Acetic acid California Director'sList of Hazardous Subtances (8 CCR 339): Acetic acid TSCA 8(b) inventory: Acetic acid CERCLA: Hazardous substances.:Acetic acid: 5000 lbs. (2268 kg)

Other Regulations:OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200). EINECS: This product is on theEuropean Inventory of Existing Commercial Chemical Substances.

Other Classifications:

WHMIS (Canada):CLASS B-3: Combustible liquid with a flash point between 37.8°C (100°F) and 93.3°C (200°F). CLASS E: Corrosive liquid.

DSCL (EEC):R10- Flammable. R35- Causes severe burns. S23- Do not breathe gas/fumes/vapour/spray [***] S26- In case of contact witheyes, rinse immediately with plenty of water and seek medical advice. S45- In case of accident or if you feel unwell, seekmedical advice immediately (show the label where possible).

HMIS (U.S.A.):

Health Hazard: 3

Fire Hazard: 2

Reactivity: 0

Personal Protection: H

National Fire Protection Association (U.S.A.):

Health: 3

Flammability: 2

Reactivity: 0

Specific hazard:

Protective Equipment:Gloves (impervious). Synthetic apron. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Wearappropriate respirator when ventilation is inadequate. Splash goggles.

Section 16: Other Information

References: Not available.

Other Special Considerations: Not available.

Created: 10/09/2005 03:35 PM

Last Updated: 05/21/2013 12:00 PM

The information above is believed to be accurate and represents the best information currently available to us. However, wemake no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume

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no liability resulting from its use. Users should make their own investigations to determine the suitability of the information fortheir particular purposes. In no event shall ScienceLab.com be liable for any claims, losses, or damages of any third party or forlost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if ScienceLab.comhas been advised of the possibility of such damages.

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Material Safety Data SheetAcetic anhydride MSDS

Section 1: Chemical Product and Company Identification

Product Name: Acetic anhydride

Catalog Codes: SLA1693

CAS#: 108-24-7

RTECS: AK1925000

TSCA: TSCA 8(b) inventory: Acetic anhydride

CI#: Not available.

Synonym:

Chemical Formula: (CH3CO)2)

Contact Information:

Sciencelab.com, Inc.14025 Smith Rd.Houston, Texas 77396

US Sales: 1-800-901-7247International Sales: 1-281-441-4400

Order Online: ScienceLab.com

CHEMTREC (24HR Emergency Telephone), call:1-800-424-9300

International CHEMTREC, call: 1-703-527-3887

For non-emergency assistance, call: 1-281-441-4400

Section 2: Composition and Information on Ingredients

Composition:

Name CAS # % by Weight

Acetic anhydride 108-24-7 100

Toxicological Data on Ingredients: Acetic anhydride: ORAL (LD50): Acute: 1780 mg/kg [Rat]. DERMAL (LD50): Acute: 4000mg/kg [Rabbit].

Section 3: Hazards Identification

Potential Acute Health Effects:Extremely hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation. Very hazardous incase of skin contact (corrosive). Hazardous in case of skin contact (permeator). Liquid or spray mist may produce tissuedamage particularly on mucous membranes of eyes, mouth and respiratory tract. Skin contact may produce burns. Inhalationof the spray mist may produce severe irritation of respiratory tract, characterized by coughing, choking, or shortness of breath.Inflammation of the eye is characterized by redness, watering, and itching. Skin inflammation is characterized by itching,scaling, reddening, or, occasionally, blistering.

Potential Chronic Health Effects:CARCINOGENIC EFFECTS: Not available. MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS: Not available.DEVELOPMENTAL TOXICITY: Not available. The substance is toxic to lungs, mucous membranes. Repeated or prolongedexposure to the substance can produce target organs damage. Repeated or prolonged contact with spray mist may producechronic eye irritation and severe skin irritation. Repeated or prolonged exposure to spray mist may produce respiratory tractirritation leading to frequent attacks of bronchial infection.

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Section 4: First Aid Measures

Eye Contact:Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15minutes. Get medical attention immediately.

Skin Contact:In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothingand shoes. Cover the irritated skin with an emollient. Wash clothing before reuse. Thoroughly clean shoes before reuse. Getmedical attention immediately.

Serious Skin Contact:Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek immediate medicalattention.

Inhalation:If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medicalattention immediately.

Serious Inhalation:Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or waistband. Ifbreathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth resuscitation. WARNING: It maybe hazardous to the person providing aid to give mouth-to-mouth resuscitation when the inhaled material is toxic, infectious orcorrosive. Seek immediate medical attention.

Ingestion:Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconsciousperson. If large quantities of this material are swallowed, call a physician immediately. Loosen tight clothing such as a collar,tie, belt or waistband.

Serious Ingestion: Not available.

Section 5: Fire and Explosion Data

Flammability of the Product: Flammable.

Auto-Ignition Temperature: 316°C (600.8°F)

Flash Points: CLOSED CUP: 49°C (120.2°F). OPEN CUP: 51°C (123.8°F).

Flammable Limits: LOWER: 2.7% UPPER: 10.3%

Products of Combustion: These products are carbon oxides (CO, CO2).

Fire Hazards in Presence of Various Substances: Flammable in presence of heat.

Explosion Hazards in Presence of Various Substances:Risks of explosion of the product in presence of mechanical impact: Not available. Risks of explosion of the product inpresence of static discharge: Not available.

Fire Fighting Media and Instructions:Flammable liquid. SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use alcohol foam, water spray or fog. Coolcontaining vessels with water jet in order to prevent pressure build-up, autoignition or explosion.

Special Remarks on Fire Hazards: Not available.

Special Remarks on Explosion Hazards: Not available.

Section 6: Accidental Release Measures

Small Spill: Absorb with an inert material and put the spilled material in an appropriate waste disposal.

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Large Spill:Flammable liquid. Corrosive liquid. Keep away from heat. Keep away from sources of ignition. Stop leak if without risk. Absorbwith DRY earth, sand or other non-combustible material. Do not get water inside container. Do not touch spilled material.Use water spray curtain to divert vapor drift. Prevent entry into sewers, basements or confined areas; dike if needed. Callfor assistance on disposal. Be careful that the product is not present at a concentration level above TLV. Check TLV on theMSDS and with local authorities.

Section 7: Handling and Storage

Precautions:Keep container dry. Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material.Do not ingest. Do not breathe gas/fumes/ vapor/spray. Never add water to this product. In case of insufficient ventilation,wear suitable respiratory equipment. If ingested, seek medical advice immediately and show the container or the label. Avoidcontact with skin and eyes.

Storage:Store in a segregated and approved area. Keep container in a cool, well-ventilated area. Keep container tightly closed andsealed until ready for use. Avoid all possible sources of ignition (spark or flame).

Section 8: Exposure Controls/Personal Protection

Engineering Controls:Provide exhaust ventilation or other engineering controls to keep the airborne concentrations of vapors below their respectivethreshold limit value. Ensure that eyewash stations and safety showers are proximal to the work-station location.

Personal Protection:Face shield. Full suit. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Gloves. Boots.

Personal Protection in Case of a Large Spill:Splash goggles. Full suit. Vapor respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoidinhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling thisproduct.

Exposure Limits:TWA: 5 TWA: 20 Consult local authorities for acceptable exposure limits.

Section 9: Physical and Chemical Properties

Physical state and appearance: Liquid.

Odor: Strong.

Taste: Strong.

Molecular Weight: 102.09 g/mole

Color: Light.

pH (1% soln/water): Not available.

Boiling Point: 139.9°C (283.8°F)

Melting Point: -73.1 (-99.6°F)

Critical Temperature: Not available.

Specific Gravity: 1.08 (Water = 1)

Vapor Pressure: 0.5 kPa (@ 20°C)

Vapor Density: 3.52 (Air = 1)

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Volatility: Not available.

Odor Threshold: 0.1 ppm

Water/Oil Dist. Coeff.: Not available.

Ionicity (in Water): Not available.

Dispersion Properties: Not available.

Solubility: Not available.

Section 10: Stability and Reactivity Data

Stability: The product is stable.

Instability Temperature: Not available.

Conditions of Instability: Not available.

Incompatibility with various substances: Not available.

Corrosivity: Not available.

Special Remarks on Reactivity: Not available.

Special Remarks on Corrosivity: Not available.

Polymerization: Will not occur.

Section 11: Toxicological Information

Routes of Entry: Dermal contact. Eye contact. Inhalation. Ingestion.

Toxicity to Animals:WARNING: THE LC50 VALUES HEREUNDER ARE ESTIMATED ON THE BASIS OF A 4-HOUR EXPOSURE. Acute oraltoxicity (LD50): 1780 mg/kg [Rat]. Acute dermal toxicity (LD50): 4000 mg/kg [Rabbit]. Acute toxicity of the vapor (LC50): 10004 hours [Rat].

Chronic Effects on Humans: Causes damage to the following organs: lungs, mucous membranes.

Other Toxic Effects on Humans:Extremely hazardous in case of skin contact (irritant), of ingestion, . Very hazardous in case of skin contact (corrosive).Hazardous in case of skin contact (permeator), of eye contact (corrosive), of inhalation (lung corrosive).

Special Remarks on Toxicity to Animals: Not available.

Special Remarks on Chronic Effects on Humans: Not available.

Special Remarks on other Toxic Effects on Humans: Not available.

Section 12: Ecological Information

Ecotoxicity: Not available.

BOD5 and COD: Not available.

Products of Biodegradation:Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise.

Toxicity of the Products of Biodegradation: The products of degradation are less toxic than the product itself.

Special Remarks on the Products of Biodegradation: Not available.

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Section 13: Disposal Considerations

Waste Disposal:

Section 14: Transport Information

DOT Classification: Class 8: Corrosive material

Identification: : Acetic Anhydride UNNA: UN1715 PG: II

Special Provisions for Transport: Not available.

Section 15: Other Regulatory Information

Federal and State Regulations:Pennsylvania RTK: Acetic anhydride Massachusetts RTK: Acetic anhydride TSCA 8(b) inventory: Acetic anhydride CERCLA:Hazardous substances.: Acetic anhydride

Other Regulations: OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200).

Other Classifications:

WHMIS (Canada):CLASS B-3: Combustible liquid with a flash point between 37.8°C (100°F) and 93.3°C (200°F). CLASS E: Corrosive liquid.

DSCL (EEC):R10- Flammable. R20/22- Harmful by inhalation and if swallowed. R34- Causes burns.

HMIS (U.S.A.):

Health Hazard: 3

Fire Hazard: 2

Reactivity: 0

Personal Protection:

National Fire Protection Association (U.S.A.):

Health: 3

Flammability: 2

Reactivity: 1

Specific hazard:

Protective Equipment:Gloves. Full suit. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respiratorwhen ventilation is inadequate. Face shield.

Section 16: Other Information

References: Not available.

Other Special Considerations: Not available.

Created: 10/10/2005 08:13 PM

Last Updated: 05/21/2013 12:00 PM

The information above is believed to be accurate and represents the best information currently available to us. However, wemake no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume

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no liability resulting from its use. Users should make their own investigations to determine the suitability of the information fortheir particular purposes. In no event shall ScienceLab.com be liable for any claims, losses, or damages of any third party or forlost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if ScienceLab.comhas been advised of the possibility of such damages.

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Material Safety Data SheetAcetone MSDS

Section 1: Chemical Product and Company Identification

Product Name: Acetone

Catalog Codes: SLA3502, SLA1645, SLA3151, SLA3808

CAS#: 67-64-1

RTECS: AL3150000

TSCA: TSCA 8(b) inventory: Acetone

CI#: Not applicable.

Synonym: 2-propanone; Dimethyl Ketone;Dimethylformaldehyde; Pyroacetic Acid

Chemical Name: Acetone

Chemical Formula: C3-H6-O

Contact Information:

Sciencelab.com, Inc.14025 Smith Rd.Houston, Texas 77396

US Sales: 1-800-901-7247International Sales: 1-281-441-4400

Order Online: ScienceLab.com

CHEMTREC (24HR Emergency Telephone), call:1-800-424-9300

International CHEMTREC, call: 1-703-527-3887

For non-emergency assistance, call: 1-281-441-4400

Section 2: Composition and Information on Ingredients

Composition:

Name CAS # % by Weight

Acetone 67-64-1 100

Toxicological Data on Ingredients: Acetone: ORAL (LD50): Acute: 5800 mg/kg [Rat]. 3000 mg/kg [Mouse]. 5340 mg/kg[Rabbit]. VAPOR (LC50): Acute: 50100 mg/m 8 hours [Rat]. 44000 mg/m 4 hours [Mouse].

Section 3: Hazards Identification

Potential Acute Health Effects:Hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation. Slightly hazardous in case ofskin contact (permeator).

Potential Chronic Health Effects:CARCINOGENIC EFFECTS: A4 (Not classifiable for human or animal.) by ACGIH. MUTAGENIC EFFECTS: Not available.TERATOGENIC EFFECTS: Not available. DEVELOPMENTAL TOXICITY: Classified Reproductive system/toxin/female,Reproductive system/toxin/male [SUSPECTED]. The substance is toxic to central nervous system (CNS). The substance maybe toxic to kidneys, the reproductive system, liver, skin. Repeated or prolonged exposure to the substance can produce targetorgans damage.

Section 4: First Aid Measures

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Eye Contact:Check for and remove any contact lenses. Immediately flush eyes with running water for at least 15 minutes, keeping eyelidsopen. Cold water may be used. Get medical attention.

Skin Contact:In case of contact, immediately flush skin with plenty of water. Cover the irritated skin with an emollient. Remove contaminatedclothing and shoes. Cold water may be used.Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medicalattention.

Serious Skin Contact:Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek medical attention.

Inhalation:If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medicalattention if symptoms appear.

Serious Inhalation:Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or waistband. Ifbreathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth resuscitation. Seek medicalattention.

Ingestion:Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconsciousperson. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention if symptoms appear.

Serious Ingestion: Not available.

Section 5: Fire and Explosion Data

Flammability of the Product: Flammable.

Auto-Ignition Temperature: 465°C (869°F)

Flash Points: CLOSED CUP: -20°C (-4°F). OPEN CUP: -9°C (15.8°F) (Cleveland).

Flammable Limits: LOWER: 2.6% UPPER: 12.8%

Products of Combustion: These products are carbon oxides (CO, CO2).

Fire Hazards in Presence of Various Substances: Highly flammable in presence of open flames and sparks, of heat.

Explosion Hazards in Presence of Various Substances:Risks of explosion of the product in presence of mechanical impact: Not available. Slightly explosive in presence of openflames and sparks, of oxidizing materials, of acids.

Fire Fighting Media and Instructions:Flammable liquid, soluble or dispersed in water. SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use alcohol foam,water spray or fog.

Special Remarks on Fire Hazards: Vapor may travel considerable distance to source of ignition and flash back.

Special Remarks on Explosion Hazards:Forms explosive mixtures with hydrogen peroxide, acetic acid, nitric acid, nitric acid + sulfuric acid, chromic anydride, chromylchloride, nitrosyl chloride, hexachloromelamine, nitrosyl perchlorate, nitryl perchlorate, permonosulfuric acid, thiodiglycol +hydrogen peroxide, potassium ter-butoxide, sulfur dichloride, 1-methyl-1,3-butadiene, bromoform, carbon, air, chloroform,thitriazylperchlorate.

Section 6: Accidental Release Measures

Small Spill:Dilute with water and mop up, or absorb with an inert dry material and place in an appropriate waste disposal container.

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Large Spill:Flammable liquid. Keep away from heat. Keep away from sources of ignition. Stop leak if without risk. Absorb with DRY earth,sand or other non-combustible material. Do not touch spilled material. Prevent entry into sewers, basements or confinedareas; dike if needed. Be careful that the product is not present at a concentration level above TLV. Check TLV on the MSDSand with local authorities.

Section 7: Handling and Storage

Precautions:Keep locked up.. Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Donot ingest. Do not breathe gas/fumes/ vapor/spray. Wear suitable protective clothing. In case of insufficient ventilation, wearsuitable respiratory equipment. If ingested, seek medical advice immediately and show the container or the label. Avoidcontact with skin and eyes. Keep away from incompatibles such as oxidizing agents, reducing agents, acids, alkalis.

Storage:Store in a segregated and approved area (flammables area) . Keep container in a cool, well-ventilated area. Keep containertightly closed and sealed until ready for use. Keep away from direct sunlight and heat and avoid all possible sources of ignition(spark or flame).

Section 8: Exposure Controls/Personal Protection

Engineering Controls:Provide exhaust ventilation or other engineering controls to keep the airborne concentrations of vapors below their respectivethreshold limit value. Ensure that eyewash stations and safety showers are proximal to the work-station location.

Personal Protection:Splash goggles. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Gloves.

Personal Protection in Case of a Large Spill:Splash goggles. Full suit. Vapor respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoidinhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling thisproduct.

Exposure Limits:TWA: 500 STEL: 750 (ppm) from ACGIH (TLV) [United States] TWA: 750 STEL: 1000 (ppm) from OSHA (PEL) [UnitedStates] TWA: 500 STEL: 1000 [Austalia] TWA: 1185 STEL: 2375 (mg/m3) [Australia] TWA: 750 STEL: 1500 (ppm) [UnitedKingdom (UK)] TWA: 1810 STEL: 3620 (mg/m3) [United Kingdom (UK)] TWA: 1800 STEL: 2400 from OSHA (PEL) [UnitedStates]Consult local authorities for acceptable exposure limits.

Section 9: Physical and Chemical Properties

Physical state and appearance: Liquid.

Odor: Fruity. Mint-like. Fragrant. Ethereal

Taste: Pungent, Sweetish

Molecular Weight: 58.08 g/mole

Color: Colorless. Clear

pH (1% soln/water): Not available.

Boiling Point: 56.2°C (133.2°F)

Melting Point: -95.35 (-139.6°F)

Critical Temperature: 235°C (455°F)

Specific Gravity: 0.79 (Water = 1)

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Vapor Pressure: 24 kPa (@ 20°C)

Vapor Density: 2 (Air = 1)

Volatility: Not available.

Odor Threshold: 62 ppm

Water/Oil Dist. Coeff.: The product is more soluble in water; log(oil/water) = -0.2

Ionicity (in Water): Not available.

Dispersion Properties: See solubility in water.

Solubility: Easily soluble in cold water, hot water.

Section 10: Stability and Reactivity Data

Stability: The product is stable.

Instability Temperature: Not available.

Conditions of Instability: Excess heat, ignition sources, exposure to moisture, air, or water, incompatible materials.

Incompatibility with various substances: Reactive with oxidizing agents, reducing agents, acids, alkalis.

Corrosivity: Non-corrosive in presence of glass.

Special Remarks on Reactivity: Not available.

Special Remarks on Corrosivity: Not available.

Polymerization: Will not occur.

Section 11: Toxicological Information

Routes of Entry: Absorbed through skin. Dermal contact. Eye contact. Inhalation.

Toxicity to Animals:WARNING: THE LC50 VALUES HEREUNDER ARE ESTIMATED ON THE BASIS OF A 4-HOUR EXPOSURE. Acute oraltoxicity (LD50): 3000 mg/kg [Mouse]. Acute toxicity of the vapor (LC50): 44000 mg/m3 4 hours [Mouse].

Chronic Effects on Humans:CARCINOGENIC EFFECTS: A4 (Not classifiable for human or animal.) by ACGIH. DEVELOPMENTAL TOXICITY: ClassifiedReproductive system/toxin/female, Reproductive system/toxin/male [SUSPECTED]. Causes damage to the following organs:central nervous system (CNS). May cause damage to the following organs: kidneys, the reproductive system, liver, skin.

Other Toxic Effects on Humans:Hazardous in case of skin contact (irritant), of ingestion, of inhalation. Slightly hazardous in case of skin contact (permeator).

Special Remarks on Toxicity to Animals: Not available.

Special Remarks on Chronic Effects on Humans:May affect genetic material (mutagenicity) based on studies with yeast (S. cerevisiae), bacteria, and hamster fibroblast cells.May cause reproductive effects (fertility) based upon animal studies. May contain trace amounts of benzene and formaldehydewhich may cancer and birth defects. Human: passes the placental barrier.

Special Remarks on other Toxic Effects on Humans:Acute Potential Health Effects: Skin: May cause skin irritation. May be harmful if absorbed through the skin. Eyes: Causeseye irritation, characterized by a burning sensation, redness, tearing, inflammation, and possible corneal injury. Inhalation:Inhalation at high concentrations affects the sense organs, brain and causes respiratory tract irritation. It also may affect theCentral Nervous System (behavior) characterized by dizzness, drowsiness, confusion, headache, muscle weakeness, andpossibly motor incoordination, speech abnormalities, narcotic effects and coma. Inhalation may also affect the gastrointestinaltract (nausea, vomiting). Ingestion: May cause irritation of the digestive (gastrointestinal) tract (nausea, vomiting). It may also

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affect the Central Nevous System (behavior), characterized by depression, fatigue, excitement, stupor, coma, headache,altered sleep time, ataxia, tremors as well at the blood, liver, and urinary system (kidney, bladder, ureter) and endocrinesystem. May also have musculoskeletal effects. Chronic Potential Health Effects: Skin: May cause dermatitis. Eyes: Eyeirritation.

Section 12: Ecological Information

Ecotoxicity:Ecotoxicity in water (LC50): 5540 mg/l 96 hours [Trout]. 8300 mg/l 96 hours [Bluegill]. 7500 mg/l 96 hours [Fatthead Minnow].0.1 ppm any hours [Water flea].

BOD5 and COD: Not available.

Products of Biodegradation:Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise.

Toxicity of the Products of Biodegradation: The product itself and its products of degradation are not toxic.

Special Remarks on the Products of Biodegradation: Not available.

Section 13: Disposal Considerations

Waste Disposal:Waste must be disposed of in accordance with federal, state and local environmental control regulations.

Section 14: Transport Information

DOT Classification: CLASS 3: Flammable liquid.

Identification: : Acetone UNNA: 1090 PG: II

Special Provisions for Transport: Not available.

Section 15: Other Regulatory Information

Federal and State Regulations:California prop. 65: This product contains the following ingredients for which the State of California has found to causereproductive harm (male) which would require a warning under the statute: Benzene California prop. 65: This product containsthe following ingredients for which the State of California has found to cause birth defects which would require a warning underthe statute: Benzene California prop. 65: This product contains the following ingredients for which the State of California hasfound to cause cancer which would require a warning under the statute: Benzene, Formaldehyde Connecticut hazardousmaterial survey.: Acetone Illinois toxic substances disclosure to employee act: Acetone Illinois chemical safety act: AcetoneNew York release reporting list: Acetone Rhode Island RTK hazardous substances: Acetone Pennsylvania RTK: AcetoneFlorida: Acetone Minnesota: Acetone Massachusetts RTK: Acetone Massachusetts spill list: Acetone New Jersey: AcetoneNew Jersey spill list: Acetone Louisiana spill reporting: Acetone California List of Hazardous Substances (8 CCR 339):Acetone TSCA 8(b) inventory: Acetone TSCA 4(a) final test rules: Acetone TSCA 8(a) IUR: Acetone

Other Regulations:OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200). EINECS: This product is on theEuropean Inventory of Existing Commercial Chemical Substances.

Other Classifications:

WHMIS (Canada):CLASS B-2: Flammable liquid with a flash point lower than 37.8°C (100°F). CLASS D-2B: Material causing other toxic effects(TOXIC).

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DSCL (EEC):R11- Highly flammable. R36- Irritating to eyes. S9- Keep container in a well-ventilated place. S16- Keep away from sources ofignition - No smoking. S26- In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

HMIS (U.S.A.):

Health Hazard: 2

Fire Hazard: 3

Reactivity: 0

Personal Protection: h

National Fire Protection Association (U.S.A.):

Health: 1

Flammability: 3

Reactivity: 0

Specific hazard:

Protective Equipment:Gloves. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respiratorwhen ventilation is inadequate. Splash goggles.

Section 16: Other Information

References:-Material safety data sheet issued by: la Commission de la Santé et de la Sécurité du Travail du Québec. -The Sigma-Aldrich Library of Chemical Safety Data, Edition II. -Hawley, G.G.. The Condensed Chemical Dictionary, 11e ed., New YorkN.Y., Van Nostrand Reinold, 1987. LOLI, RTECS, HSDB databases. Other MSDSs

Other Special Considerations: Not available.

Created: 10/10/2005 08:13 PM

Last Updated: 05/21/2013 12:00 PM

The information above is believed to be accurate and represents the best information currently available to us. However, wemake no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assumeno liability resulting from its use. Users should make their own investigations to determine the suitability of the information fortheir particular purposes. In no event shall ScienceLab.com be liable for any claims, losses, or damages of any third party or forlost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if ScienceLab.comhas been advised of the possibility of such damages.

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Material Safety Data Sheet (Activated Carbon)

415 Huguenot Street New Rochelle, NY 10801 Phone: (914) 654-6800 Fax: (914) 654-6899

DATE PREPARED: 6/18/2009 REVISION NUMBER: 6/18/2009 EMERGENCY NUMBER: CHEMTREC: 1-800-424-9300

SECTION 1 – PRODUCT AND COMPANY INFORMATION

PRODUCT NAME Activated Carbon SYNONYM Charcoal, Activated FORMULA C CAS NUMBER 7440-44-0

SECTION 2 – COMPOSITON/INFORMATION ON INGREDIENTS

PRODUCT NAME CAS NUMBER PURITY Activated Carbon 7440-44-0 90 - 100%

SECTION 3- HAZARDS IDENTIFICATION Emergency Overview CAUTION! ACTIVATED CARBON AFFECTS THE RESPIRATORY AND CARDIOVASCULAR SYSTEMS. SAF-T-DATA(tm) Ratings (Provided here for your convenience) Health Rating: 2 - Moderate Flammability Rating: 1 - Slight Reactivity Rating: 1 - Slight Contact Rating: 1 - Slight Lab Protective Equip: GOGGLES; LAB COAT; VENT HOOD; PROPER GLOVES Storage Color Code: Green (General Storage) Potential Health Effects Inhalation: No adverse effects expected. May cause mild irritation to the respiratory tract. Ingestion: No adverse effects expected. May cause mild irritation to the gastrointestinal tract. Skin Contact: Not expected to be a health hazard from skin exposure. May cause mild irritation and redness. Eye Contact: No adverse effects expected. May cause mild irritation, possible reddening. Chronic Exposure: Prolonged inhalation of excessive dust may produce pulmonary disorders. Aggravation of Pre-existing Conditions: No information found.

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Material Safety Data Sheet (Activated Carbon)

SECTION 4 – FIRST AID MEASURES Inhalation: Remove to fresh air. Get medical attention for any breathing difficulty. Ingestion: Give several glasses of water to drink to dilute. If large amounts were swallowed, get medical advice. Skin Contact: Not expected to require first aid measures. Wash exposed area with soap and water. Get medical advice if irritation develops. Eye Contact: Wash thoroughly with running water. Get medical advice if irritation develops.

SECTION 5 – FIRE FIGHTING MEASURES Fire: As with most organic solids, fire is possible at elevated temperatures or by contact with an ignition source. Activated carbon is difficult to ignite and tends to burn slowly (smolder) without producing smoke or flame.

Wet activated carbon depletes oxygen from the air. Materials allowed to smolder for long periods in enclosed spaces, may produce amounts of carbon monoxide which may reach the lower explosive limit for carbon monoxide of 12.5% in air.

Contact with strong oxidizers such as ozone or liquid oxygen may cause rapid combustion.

Explosion: Fine dust dispersed in air in sufficient concentrations, and in the presence of an ignition source is a potential dust explosion hazard. Minimum explosible concentration 0.140 g/l.

Fire Extinguishing Media: Water spray, dry chemical, alcohol foam, or carbon dioxide.

Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full facepiece operated in the pressure demand or other positive pressure mode.

SECTION 6 – ACCIDENTAL RELEASE MEASURES

Remove all sources of ignition. Ventilate area of leak or spill. Wear appropriate personal protective equipment as specified in Section 8. Spills: Clean up spills in a manner that does not disperse dust into the air. Use non-sparking tools and equipment. Reduce airborne dust and prevent scattering by moistening with water. Pick up spill for recovery or disposal and place in a closed container. Warning! Spent product may have absorbed hazardous materials.

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Material Safety Data Sheet (Activated Carbon)

SECTION 7- HANDLING AND STORAGE

Keep in a tightly closed container, stored in a cool, dry, ventilated area. Protect against physical damage. Keep away from moisture and oxidizers. Avoid dust dispersal. Wet activated carbon depletes oxygen from the air and therefore dangerously low levels of oxygen may be encountered in confined spaces. Work procedures for potentially low oxygen areas should be followed. Containers of this material may be hazardous when empty since they retain product residues (dust, solids); observe all warnings and precautions listed for the product.

SECTION 8 - EXPOSURE CONTROLS/ PERSONAL PROTECTION

Airborne Exposure Limits: - OSHA Permissible Exposure Limits (PELs):

activated carbon (graphite, synthetic): total particulate = 15 mg/m3 (TWA), respirable fraction = 5 mg/m3 (TWA).

- ACGIH Threshold Limit Values (TLVs): graphite, all forms except graphite fibers: 2 mg/m3 (TWA).

Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures below the Airborne Exposure Limits.

Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area.

Please refer to the ACGIH document, Industrial Ventilation, A Manual of Recommended Practices, most recent edition, for details.

Personal Respirators (NIOSH Approved): For conditions of use where exposure to the dust or mist is apparent, a half-face dust/mist respirator may be worn. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator. WARNING: Air-purifying respirators do not protect workers in oxygen-deficient atmospheres. Skin Protection: Wear protective gloves and clean body-covering clothing. Eye Protection: Use chemical safety goggles. Maintain eye wash fountain and quick-drench facilities in work area.

SECTION 9 – PHYSICAL AND CHEMICAL PROPERTIES

Appearance: Black powder.

Odor: Odorless.

Solubility: Insoluble in water.

Specific Gravity: 1.8 - 2.1

pH: 5.0-10.0

% Volatiles by volume @ 21C (70F): 0

Boiling Point: Sublimes.

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Material Safety Data Sheet (Activated Carbon)

Melting Point: 3550C (6422F)

Vapor Density (Air=1): 0.4

Vapor Pressure (mm Hg): 1 @ 3586C (6487F)

Evaporation Rate (BuAc=1): No information found.

SECTION 10 – STABILITY AND REACTIVITY DATA

Stability: Stable under ordinary conditions of use and storage. Hazardous Decomposition Products: Involvement in a fire causes formation of carbon dioxide and carbon monoxide. Hazardous Polymerization: Will not occur. Incompatibilities: Strong oxidizers such as ozone, liquid oxygen, chlorine, permanganate, etc. may result in rapid combustion. Avoid contact with strong acids. Conditions to Avoid: Moisture and incompatibles.

SECTION 11 – TOXICOLOGICAL INFORMATION

Investigated as a reproductive effector. --------------------------------\Cancer Lists\------------------------------------------------------ ---NTP Carcinogen--- Ingredient Known Anticipated IARC Category ------------------------------------ ----- ----------- ------------- Steam Activated Carbon (7440-44-0) No No None

SECTION 12 – ECOLOGICAL INFORMATION

Environmental Fate: No information found.

Environmental Toxicity: No information found.

SECTION 13 – DISPOSAL CONSIDERATION

Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste disposal facility. Processing, use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of container and unused contents in accordance with federal, state and local requirements.

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Material Safety Data Sheet (Activated Carbon)

SECTION 14 - TRANSPORTATION DATA

Not regulated.

SECTION 15 – REGULATORY INFORMATION

--------\Chemical Inventory Status - Part 1\--------------------------------- Ingredient TSCA EC Japan Australia ----------------------------------------------- ---- --- ----- --------- Steam Activated Carbon (7440-44-0) Yes Yes No Yes ---------\Chemical Inventory Status - Part 2\--------------------------------- --Canada-- Ingredient Korea DSL NDSL Phil. ----------------------------------------------- ----- --- ---- ----- Steam Activated Carbon (7440-44-0) Yes Yes No Yes ----------\Federal, State & International Regulations - Part 1\---------------- -SARA 302- ------SARA 313------ Ingredient RQ TPQ List Chemical Catg. ----------------------------------------- --- ----- ---- -------------- Steam Activated Carbon (7440-44-0) No No No No --------\Federal, State & International Regulations - Part 2\---------------- -RCRA- -TSCA- Ingredient CERCLA 261.33 8(d) ----------------------------------------- ------ ------ ------ Steam Activated Carbon (7440-44-0) No No No Chemical Weapons Convention: No TSCA 12(b): No CDTA: No SARA 311/312: Acute: Yes Chronic: No Fire: No Pressure: No Reactivity: No (Pure / Solid)

Australian Hazchem Code: None allocated.

Poison Schedule: None allocated.

WHMIS: This MSDS has been prepared according to the hazard criteria of the Controlled Products Regulations (CPR) and the MSDS contains all of the information required by the CPR.

SECTION 16 – OTHER INFORMATION

NFPA Ratings: Health: 0 Flammability: 1 Reactivity: 0

Label Hazard Warning: CAUTION! ACTIVATED CARBON AFFECTS THE RESPIRATORY AND CARDIOVASCULAR SYSTEMS.

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Material Safety Data Sheet (Activated Carbon)

Label Precautions: Avoid contact with eyes, skin and clothing. Avoid breathing dust. Keep container closed. Use with adequate ventilation. Wash thoroughly after handling. Label First Aid: If inhaled, remove to fresh air. Get medical attention for any breathing difficulty. Product Use: Laboratory Reagent. Disclaimer The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product.

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Material Safety Data SheetCharcoal, Activated, Powder MSDS

Section 1: Chemical Product and Company Identification

Product Name: Charcoal, Activated, Powder

Catalog Codes: SLC3982, SLC1189

CAS#: 7440-44-0

RTECS: FL7243500

TSCA: TSCA 8(b) inventory: Charcoal, Activated

CI#: Not available.

Synonym:

Chemical Name: Charcoal, Activated

Chemical Formula: C

Contact Information:

Sciencelab.com, Inc.14025 Smith Rd.Houston, Texas 77396

US Sales: 1-800-901-7247International Sales: 1-281-441-4400

Order Online: ScienceLab.com

CHEMTREC (24HR Emergency Telephone), call:1-800-424-9300

International CHEMTREC, call: 1-703-527-3887

For non-emergency assistance, call: 1-281-441-4400

Section 2: Composition and Information on Ingredients

Composition:

Name CAS # % by Weight

Charcoal, Activated 7440-44-0 100

Toxicological Data on Ingredients: Charcoal, Activated LD50: Not available. LC50: Not available.

Section 3: Hazards Identification

Potential Acute Health Effects: Slightly hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, ofinhalation.

Potential Chronic Health Effects:CARCINOGENIC EFFECTS: Not available. MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS: Not available.DEVELOPMENTAL TOXICITY: Not available. The substance is toxic to mucous membranes. The substance may be toxic tolungs. Repeated or prolonged exposure to the substance can produce target organs damage.

Section 4: First Aid Measures

Eye Contact:Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15minutes. Get medical attention if irritation occurs.

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Skin Contact: Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops.

Serious Skin Contact: Not available.

Inhalation:If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medicalattention.

Serious Inhalation:Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or waistband. Seekmedical attention.

Ingestion:Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconsciousperson. If large quantities of this material are swallowed, call a physician immediately. Loosen tight clothing such as a collar,tie, belt or waistband.

Serious Ingestion: Not available.

Section 5: Fire and Explosion Data

Flammability of the Product: Flammable.

Auto-Ignition Temperature: 452°C (845.6°F)

Flash Points: Not available.

Flammable Limits: Not available.

Products of Combustion: Not available.

Fire Hazards in Presence of Various Substances:Highly flammable in presence of open flames and sparks, of heat. Non-flammable in presence of shocks.

Explosion Hazards in Presence of Various Substances:Risks of explosion of the product in presence of mechanical impact: Not available. Risks of explosion of the product inpresence of static discharge: Not available.

Fire Fighting Media and Instructions:Flammable solid. SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use water spray or fog. Cool containing vesselswith water jet in order to prevent pressure build-up, autoignition or explosion.

Special Remarks on Fire Hazards:Flammable/combustible material. May be ignited by friction, heat, sparks, or flames. May reignite after fire is extinguished.Freshly prepared material may heat spontaneously in air, and presence of water accelerates this.

Special Remarks on Explosion Hazards:Material in powder form, capable of creating a dust explosion (forming explosive mixtures in air) when exposed to heat, flame,or ammonium nitrate + heat. ammonium tetrachloride at 240 C, bromates, Ca(OCl)2, chlorates, Cl2, (Cl2 + Cr(OCl)2), ClO, F2,iodates, IO5, (Pb(NO3)2, HgNO3, HNO3, (oils + air), (potassium + air), Na2S, Zn(NO3)2.

Section 6: Accidental Release Measures

Small Spill: Use appropriate tools to put the spilled solid in a convenient waste disposal container.

Large Spill:Spontaneously combustible solid. Stop leak if without risk. Absorb with an inert material and put the spilled material in anappropriate waste disposal. Obtain advice on use of water as spilled material may react with it. Do not touch spilled material.Prevent entry into sewers, basements or confined areas; dike if needed. Eliminate all ignition sources. Cover with wet earth,sand or other non-combustible material. Call for assistance on disposal. Be careful that the product is not present at aconcentration level above TLV. Check TLV on the MSDS and with local authorities.

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Section 7: Handling and Storage

Precautions:Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not breathe dust.Keep away from incompatibles such as oxidizing agents, metals, acids.

Storage:Store in a segregated and approved area. Keep in a cool and ventilated area away from combustible materials. Keepcontainer in a cool, well-ventilated area. Keep container tightly closed and sealed until ready for use. Avoid all possiblesources of ignition (spark or flame).

Section 8: Exposure Controls/Personal Protection

Engineering Controls:Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommendedexposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminantsbelow the exposure limit.

Personal Protection: Safety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent.Gloves.

Personal Protection in Case of a Large Spill:Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoidinhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling thisproduct.

Exposure Limits:TWA: 3.5 (mg/m3) from ACGIH (TLV) [United States] TWA: 4 (mg/m3) [United Kingdom (UK)] Respirable. TWA: 10 (mg/m3)[United Kingdom (UK)] Total. TWA: 2 (mg/m3) [Canada] Respirable.Consult local authorities for acceptable exposure limits.

Section 9: Physical and Chemical Properties

Physical state and appearance: Solid. (Solid powder.)

Odor: Odorless.

Taste: Not available.

Molecular Weight: 12.01 g/mole

Color: Black

pH (1% soln/water): Not applicable.

Boiling Point: Not available.

Melting Point: 3500°C (6332°F)

Critical Temperature: 6810°C (12290°F)

Specific Gravity: 3.51 (Water = 1)

Vapor Pressure: Not applicable.

Vapor Density: Not available.

Volatility: Not available.

Odor Threshold: Not available.

Water/Oil Dist. Coeff.: Not available.

Ionicity (in Water): Not available.

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Dispersion Properties: Not available.

Solubility: Insoluble in cold water, hot water.

Section 10: Stability and Reactivity Data

Stability: The product is stable.

Instability Temperature: Not available.

Conditions of Instability: Heat, ignition sources (flames, sparks), air,incompatible materials

Incompatibility with various substances: Reactive with oxidizing agents, metals, acids.

Corrosivity: Non-corrosive in presence of glass.

Special Remarks on Reactivity:Incompatible with air, unsaturated oils, 2-Nitrobenzaldehyde, strong oxidizers such as fluorine, chlorine trifluoride, andpotassium peroxide.

Special Remarks on Corrosivity: Not available.

Polymerization: Will not occur.

Section 11: Toxicological Information

Routes of Entry: Inhalation. Ingestion.

Toxicity to Animals:LD50: Not available. LC50: Not available.

Chronic Effects on Humans:Causes damage to the following organs: mucous membranes. May cause damage to the following organs: lungs.

Other Toxic Effects on Humans: Slightly hazardous in case of skin contact (irritant), of ingestion, of inhalation.

Special Remarks on Toxicity to Animals: Not available.

Special Remarks on Chronic Effects on Humans: May cause adverse reproductive effects.

Special Remarks on other Toxic Effects on Humans:Acute Potential Health Effects: Skin: May cause skin irritation. Eyes: May cause eye irritation. Inhalation: May causerespiratory tract irritation. Ingestion: May cause aspiration pneumonitis, vomiting, decreased gastrointestinal transit time,gastrointestinal obstruction, constipation, a charcoal-containing empyema, intestinal perforation, charcoal deposits in theesophageal and gastric mucosa, rectal ulcer. Chronic Potential Health Effects: Skin: Chronic skin exposure can result inclogging of hair follicles, rendering them black. Inhalation: Chronic inhalation can cause carbon particles to accumulate in thelungs. It may cause a pneumoconiosis called "Black Lung Disease" or "Coal Workers Pneumoconiosis". This is seen in coalworkers, but no evidence has been found for the equivalent with occupational exposure to activated carbon (charcoal).

Section 12: Ecological Information

Ecotoxicity: Not available.

BOD5 and COD: Not available.

Products of Biodegradation:Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise.

Toxicity of the Products of Biodegradation: The product itself and its products of degradation are not toxic.

Special Remarks on the Products of Biodegradation: Not available.

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Section 13: Disposal Considerations

Waste Disposal:Waste must be disposed of in accordance with federal, state and local environmental control regulations.

Section 14: Transport Information

DOT Classification: CLASS 4.2: Spontaneously combustible substance.

Identification: : Carbon, activated UNNA: 1362 PG: III

Special Provisions for Transport: Not available.

Section 15: Other Regulatory Information

Federal and State Regulations:Rhode Island RTK hazardous substances: Charcoal, Activated TSCA 8(b) inventory: Charcoal, Activated

Other Regulations:OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200). EINECS: This product is on theEuropean Inventory of Existing Commercial Chemical Substances.

Other Classifications:

WHMIS (Canada): Not controlled under WHMIS (Canada).

DSCL (EEC):This product is not classified according to the EU regulations. Not applicable.

HMIS (U.S.A.):

Health Hazard: 1

Fire Hazard: 3

Reactivity: 0

Personal Protection: E

National Fire Protection Association (U.S.A.):

Health: 1

Flammability: 3

Reactivity: 0

Specific hazard:

Protective Equipment:Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Safety glasses.

Section 16: Other Information

References: Not available.

Other Special Considerations: Not available.

Created: 10/09/2005 04:37 PM

Last Updated: 05/21/2013 12:00 PM

The information above is believed to be accurate and represents the best information currently available to us. However, wemake no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume

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no liability resulting from its use. Users should make their own investigations to determine the suitability of the information fortheir particular purposes. In no event shall ScienceLab.com be liable for any claims, losses, or damages of any third party or forlost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if ScienceLab.comhas been advised of the possibility of such damages.

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SAFETY DATA SHEET

Ammonia, anhydrous

Issue Date: Last revised date:

16.01.2013 18.12.2015

Version: 1. 0 SDS No.: 000010021772 1/17

SDS_GB - 000010021772

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifier

Product name: Ammonia, anhydrous

Trade name: Ammonia Heat Treatment Grade N3.8, Ammonia Micrographic Grade N3.8, Ammonia Premium Grade N3.8, Ammonia Refrigerant Grade N3.8

Additional identification

Chemical name: ammonia, anhydrous

Chemical formula: NH3 INDEX No. 007-001-00-5 CAS-No. 7664-41-7 EC No. 231-635-3 REACH Registration No. 01-2119488876-14

1.2 Relevant identified uses of the substance or mixture and uses advised against

Identified uses: Industrial and professional. Perform risk assessment prior to use. Casting operations. Explosives manufacture & use. Freezing, chilling, and packaging of foodstuffs. Manufacturing of fertilisers and nitric acid. Production of plastics. Refrigerant. Use for electronic component manufacture. Use of gas to manufacture pharmaceutical products. Using gas alone or in mixtures for the calibration of analysis equipment. Using gas as feedstock in chemical processes. Using gas for metal treatment. Washing of textiles or metal parts. Water treatment. Use in laboratories

Uses advised against Consumer use.

1.3 Details of the supplier of the safety data sheet

Supplier BOC Priestley Road, Worsley M28 2UT Manchester

Telephone: 0800 111 333

E-mail: [email protected]

1.4 Emergency telephone number: 0800 111 333

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SAFETY DATA SHEET

Ammonia, anhydrous

Issue Date: Last revised date:

16.01.2013 18.12.2015

Version: 1. 0 SDS No.: 000010021772 2/17

SDS_GB - 000010021772

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture

Classification according to Directive 67/548/EEC or 1999/45/EC as amended.

R10 T; R23 C; R34 N; R50

The full text for all R-phrases is displayed in section 16.

Classification according to Regulation (EC) No 1272/2008 as amended.

Physical Hazards

Flammable gas Category 2 H221: Flammable gas.

Gases under pressure Liquefied gas H280: Contains gas under pressure; may explode if heated.

Health Hazards

Acute toxicity (Inhalation - gas) Category 3 H331: Toxic if inhaled. Skin corrosion Category 1B H314: Causes severe skin burns and eye damage. Serious eye damage Category 1 H318: Causes serious eye damage.

Environmental Hazards

Acute hazards to the aquatic environment

Category 1 H400: Very toxic to aquatic life.

Chronic hazards to the aquatic environment

Category 2 H411: Toxic to aquatic life with long lasting effects.

2.2 Label Elements

Contains: ammonia, anhydrous

Signal Words: Danger

Hazard Statement(s): H221: Flammable gas. H280: Contains gas under pressure; may explode if heated. H314: Causes severe skin burns and eye damage. H331: Toxic if inhaled. H410: Very toxic to aquatic life with long lasting effects.

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SAFETY DATA SHEET

Ammonia, anhydrous

Issue Date: Last revised date:

16.01.2013 18.12.2015

Version: 1. 0 SDS No.: 000010021772 3/17

SDS_GB - 000010021772

Precautionary Statement

Prevention: P210: Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P260: Do not breathe gas/vapours. P273: Avoid release to the environment. P280: Wear protective gloves/protective clothing/eye protection/face protection.

Response: P303+P361+P353+P315: IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/ shower. Get immediate medical advice/attention. P304+P340+P315: IF INHALED: Remove person to fresh air and keep comfortable for breathing. Get immediate medical advice/attention. P305+P351+P338+P315: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Get immediate medical advice/attention. P377: Leaking gas fire: Do not extinguish, unless leak can be stopped safely. P381: Eliminate all ignition sources if safe to do so.

Storage: P403: Store in a well-ventilated place. P405: Store locked up.

Disposal: None.

Supplemental label information

EUH071: Corrosive to the respiratory tract.

2.3 Other hazards: Contact with evaporating liquid may cause frostbite or freezing of skin.

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SAFETY DATA SHEET

Ammonia, anhydrous

Issue Date: Last revised date:

16.01.2013 18.12.2015

Version: 1. 0 SDS No.: 000010021772 4/17

SDS_GB - 000010021772

SECTION 3: Composition/information on ingredients

3.1 Substances

Chemical name ammonia, anhydrous INDEX No.: 007-001-00-5 CAS-No.: 7664-41-7 EC No.: 231-635-3 REACH Registration No.: 01-2119488876-14 Purity: 100%

The purity of the substance in this section is used for classification only, and does not represent the actual purity of the substance as supplied, for which other documentation should be consulted.

Trade name: Ammonia Heat Treatment Grade N3.8, Ammonia Micrographic Grade N3.8, Ammonia Premium Grade N3.8, Ammonia Refrigerant Grade N3.8

SECTION 4: First Aid Measures

General: Remove victim to uncontaminated area wearing self contained breathing

apparatus. Keep victim warm and rested. Call a doctor. Apply artificial respiration if breathing stopped.

4.1 Description of first aid measures

Inhalation: Remove victim to uncontaminated area wearing self contained breathing apparatus. Keep victim warm and rested. Call a doctor. Apply artificial respiration if breathing stopped.

Eye contact: Rinse the eye with water immediately. Remove contact lenses, if present and easy to do. Continue rinsing. Flush thoroughly with water for at least 15 minutes. Get immediate medical assistance. If medical assistance is not immediately available, flush an additional 15 minutes.

Skin Contact: Immediately flush with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Get medical attention immediately. Contact with evaporating liquid may cause frostbite or freezing of skin.

Ingestion: Ingestion is not considered a potential route of exposure.

4.2 Most important symptoms and

effects, both acute and

delayed:

Causes severe skin burns and eye damage. Contact with liquefied gas can cause damage (frostbite) due to rapid evaporative cooling. May be fatal if inhaled.

4.3 Indication of any immediate medical attention and special treatment needed

Hazards: Causes severe skin burns and eye damage. Contact with liquefied gas can cause damage (frostbite) due to rapid evaporative cooling. May be fatal if inhaled.

Treatment: Thaw frosted parts with lukewarm water. Do not rub affected area. Get immediate medical advice/attention. Treat with a corticosteroid spray as soon as possible after inhalation.

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SAFETY DATA SHEET

Ammonia, anhydrous

Issue Date: Last revised date:

16.01.2013 18.12.2015

Version: 1. 0 SDS No.: 000010021772 5/17

SDS_GB - 000010021772

SECTION 5: Firefighting Measures

General Fire Hazards: Heat may cause the containers to explode.

5.1 Extinguishing media

Suitable extinguishing media: Use water spray to reduce vapours or divert vapour cloud drift. Water Spray or Fog. Dry powder. Foam.

Unsuitable extinguishing

media:

Carbon dioxide. Do not use water jet, as this may cause corrosive liquid to splash.

5.2 Special hazards arising from the

substance or mixture: Fire or excessive heat may produce hazardous decomposition products. Fire or excessive heat may produce hazardous decomposition products.

Hazardous Combustion Products: If involved in a fire the following toxic and/or corrosive fumes may be produced

by thermal decomposition: Nitrogen monoxide ; nitrogen dioxide

5.3 Advice for firefighters

Special fire fighting

procedures:

In case of fire: Stop leak if safe to do so. Use of water may result in the formation of very toxic aqueous solutions. Keep run-off water out of sewers and water sources. Dyke for water control. Continue water spray from protected position until container stays cool. Use extinguishants to contain the fire. Isolate the source of the fire or let it burn out.

Special protective equipment

for firefighters:

Gas tight chemically protective clothing (Type 1) in combination with self contained breathing apparatus. Guideline: EN 943-2 Protective clothing against liquid and gaseous chemicals, aerosols and solid particles. Performance requirements for gas-tight (Type 1) chemical protective suits for emergency teams (ET)

SECTION 6: Accidental Release Measures

6.1 Personal precautions,

protective equipment and

emergency procedures:

Evacuate area. Provide adequate ventilation. Consider the risk of potentially explosive atmospheres . Eliminate all ignition sources if safe to do so. Monitor the concentration of the released product. Prevent from entering sewers, basements and workpits, or any place where its accumulation can be dangerous. Wear self-contained breathing apparatus when entering area unless atmosphere is proved to be safe. EN 137 Respiratory protective devices - Self-contained open-circuit compressed air breathing apparatus with full face mask - Requirements, testing, marking.

6.2 Environmental Precautions: Prevent further leakage or spillage if safe to do so. Reduce vapour with fog or fine

water spray. Keep run-off water out of sewers and water sources. Dyke for water control.

6.3 Methods and material for

containment and cleaning up:

Provide adequate ventilation. Eliminate sources of ignition. Wash contaminated equipment or sites of leaks with copious quantities of water.

6.4 Reference to other sections: Refer to sections 8 and 13.

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SAFETY DATA SHEET

Ammonia, anhydrous

Issue Date: Last revised date:

16.01.2013 18.12.2015

Version: 1. 0 SDS No.: 000010021772 6/17

SDS_GB - 000010021772

SECTION 7: Handling and Storage:

7.1 Precautions for safe handling: Only experienced and properly instructed persons should handle gases under pressure. Avoid exposure - obtain special instructions before use. Use only properly specified equipment which is suitable for this product, its supply pressure and temperature. Purge system with dry inert gas (e.g. helium or nitrogen) before gas is introduced and when system is placed out of service. Purge air from system before introducing gas. Containers, which contain or have contained flammable or explosive substances, must not be inerted with liquid carbon dioxide. Assess the risk of a potentially explosive atmosphere and the need for suitable equipment i.e. explosion-proof. Take precautionary measures against static discharges. Keep away from ignition sources (including static discharges). Provide electrical earthing of equipment and electrical equipment usable in explosive atmospheres. Use only non-sparking tools. Installation of a cross purge assembly between the container and the regulator is recommended. Excess pressure must be vented through an appropriate scrubber system. Refer to supplier's handling instructions. The substance must be handled in accordance with good industrial hygiene and safety procedures. Ensure the complete system has been (or is regularly) checked for leaks before use. Protect containers from physical damage; do not drag, roll, slide or drop. Do not remove or deface labels provided by the supplier for the identification of the container contents. When moving containers, even for short distances, use appropriate equipment eg. trolley, hand truck, fork truck etc. Secure cylinders in an upright position at all times, close all valves when not in use. Provide adequate ventilation. Suck back of water into the container must be prevented. Do not allow backfeed into the container. Avoid suckback of water, acid and alkalis. Keep container below 50°C in a well ventilated place. Observe all regulations and local requirements regarding storage of containers. When using do not eat, drink or smoke. Store in accordance with local/regional/national/international regulations. Never use direct flame or electrical heating devices to raise the pressure of a container. Leave valve protection caps in place until the container has been secured against either a wall or bench or placed in a container stand and is ready for use. Damaged valves should be reported immediately to the supplier Close container valve after each use and when empty, even if still connected to equipment. Never attempt to repair or modify container valves or safety relief devices. Replace valve outlet caps or plugs and container caps where supplied as soon as container is disconnected from equipment. Keep container valve outlets clean and free from contaminates particularly oil and water. If user experiences any difficulty operating container valve discontinue use and contact supplier. Never attempt to transfer gases from one container to another. Container valve guards or caps should be in place.

7.2 Conditions for safe storage,

including any incompatibilities:

All electrical equipment in the storage areas should be compatible with the risk of a potentially explosive atmosphere. Segregate from oxidant gases and other oxidants being stored. Containers should not be stored in conditions likely to encourage corrosion. Stored containers should be periodically checked for general conditions and leakage. Keep away from food, drink and animal feeding stuffs. Container valve guards or caps should be in place. Store containers in location free from fire risk and away from sources of heat and ignition. Keep away from combustible material.

7.3 Specific end use(s): None.

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SAFETY DATA SHEET

Ammonia, anhydrous

Issue Date: Last revised date:

16.01.2013 18.12.2015

Version: 1. 0 SDS No.: 000010021772 7/17

SDS_GB - 000010021772

SECTION 8: Exposure Controls/Personal Protection

8.1 Control Parameters

Occupational Exposure Limits

Chemical name type Exposure Limit Values Source

ammonia, anhydrous TWA 25 ppm 18 mg/m3 UK. EH40 Workplace Exposure Limits (WELs) (12 2011)

STEL 35 ppm 25 mg/m3 UK. EH40 Workplace Exposure Limits (WELs) (12 2011)

TWA 20 ppm 14 mg/m3 EU. Indicative Exposure Limit Values in Directives 91/322/EEC, 2000/39/EC, 2006/15/EC, 2009/161/EU (12 2009)

STEL 50 ppm 36 mg/m3 EU. Indicative Exposure Limit Values in Directives 91/322/EEC, 2000/39/EC, 2006/15/EC, 2009/161/EU (12 2009)

DNEL-Values

Critical component type Value Remarks

ammonia, anhydrous Worker - dermal, short-term - systemic

6.8 mg/kg bw/day

-

Worker - inhalative, short-term - local

36 mg/m3 -

Worker - inhalative, long-term - local

14 mg/m3 -

Worker - inhalative, long-term - systemic

47.6 mg/m3

-

Worker - inhalative, short-term - systemic

47.6 mg/m3

-

Worker - dermal, long-term - systemic

6.8 mg/kg bw/day

-

PNEC-Values

Critical component type Value Remarks

ammonia, anhydrous Aquatic (intermit. releases) 0.0068 mg/l

-

Aquatic (marine water) 0.0011 mg/l

-

Aquatic (freshwater) 0.0011 mg/l

-

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SAFETY DATA SHEET

Ammonia, anhydrous

Issue Date: Last revised date:

16.01.2013 18.12.2015

Version: 1. 0 SDS No.: 000010021772 8/17

SDS_GB - 000010021772

8.2 Exposure controls

Appropriate engineering

controls:

Consider a work permit system e.g. for maintenance activities. Ensure adequate air ventilation. Provide adequate general and local exhaust ventilation. Keep concentrations well below occupational exposure limits. Gas detectors should be used when toxic quantities may be released. Gas detectors should be used when quantities of flammable gases or vapours may be released. Systems under pressure should be regularly checked for leakages. Product to be handled in a closed system and under strictly controlled conditions. Use only permanent leak tight installations (e.g. welded pipes). Take precautionary measures against static discharges. Do not eat, drink or smoke when using the product.

Individual protection measures, such as personal protective equipment

General information: A risk assessment should be conducted and documented in each work area to assess the risks related to the use of the product and to select the PPE that matches the relevant risk. The following recommendations should be considered. Keep self contained breathing apparatus readily available for emergency use. Personal protective equipment for the body should be selected based on the task being performed and the risks involved. Protect eyes, face and skin from contact with product. Refer to local regulations for restriction of emissions to the atmosphere. See section 13 for specific methods for waste gas treatment.

Eye/face protection: Safety eyewear, goggles or face-shield to EN166 should be used to avoid

exposure to liquid splashes. Wear eye protection to EN 166 when using gases. Guideline: EN 166 Personal Eye Protection.

Skin protection

Hand Protection: Wear working gloves while handling containers Guideline: EN 388 Protective gloves against mechanical risks. Chemically resistant gloves complying with EN 374 should be worn at all times when handling chemical products if a risk assessment indicates this is necessary. Material: Chloroprene rubber. Break-through time: 30 min Glove thickness: 0.5 mm Guideline: EN 374-1/2/3 Protective gloves against chemicals and micro-organisms. Chemically resistant gloves complying with EN 374 should be worn at all times when handling chemical products if a risk assessment indicates this is necessary. Material: Butyl rubber. Break-through time: 480 min Glove thickness: 0.7 mm Guideline: EN 374-1/2/3 Protective gloves against chemicals and micro-organisms.

Body protection: Wear fire/flame resistant/retardant clothing. Keep suitable chemically resistant

protective clothing readily available for emergency use. Guideline: ISO/TR 2801:2007 Clothing for protection against heat and flame -- General recommendations for selection, care and use of protective clothing.Guideline: EN 943 Protective clothing against liquid and gaseous chemicals, including liquid aerosols and solid particles.

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SAFETY DATA SHEET

Ammonia, anhydrous

Issue Date: Last revised date:

16.01.2013 18.12.2015

Version: 1. 0 SDS No.: 000010021772 9/17

SDS_GB - 000010021772

Other: Wear safety shoes while handling containers Guideline: ISO 20345 Personal protective equipment - Safety footwear.

Respiratory Protection: Reference should be made to European Standard EN 689 for methods for the

assessment of exposure by inhalation to chemical agents and national guidance documents for methods for the determination of hazardous substances. The selection of the Respiratory Protective Device (RPD) must be based on known or anticipated exposure levels, the hazards of the product and the safe working limits of the selected RPD. Material: Filter K Guideline: EN 14387 Respiratory protective devices. Gas filter(s) and combined filter(s). Requirements, testing, marking. Guideline: EN 136 Respiratory protective devices. Full face masks. Requirements, testing, marking.

Thermal hazards: No precautionary measures are necessary.

Hygiene measures: Obtain special instructions before use. Specific risk management measures are not

required beyond good industrial hygiene and safety procedures. Do not eat, drink or smoke when using the product.

Environmental exposure

controls:

For waste disposal, see section 13.

SECTION 9: Physical And Chemical Properties

9.1 Information on basic physical and chemical properties

Appearance

Physical state: Gas Form: Liquefied gas Colour: Colourless

Odour: ammoniacal Odour Threshold: Odour threshold is subjective and is inadequate to warn of over

exposure. pH: If dissolved in water pH-value will be affected. Melting Point: -77.7 °C Boiling Point: -33.35 °C Sublimation Point: not applicable. Critical Temp. (°C): 132.0 °C Flash Point: Not applicable to gases and gas mixtures. Evaporation Rate: Not applicable to gases and gas mixtures. Flammability (solid, gas): Flammable Gas Flammability limit - upper (%): 33.6 %(V)

Flammability limit - lower(%): 15.4 %(V) Vapour pressure: 857.1 kPa (20 °C) Vapour density (air=1): 0.59 AIR=1 Relative density: 0.8 Solubility(ies)

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SAFETY DATA SHEET

Ammonia, anhydrous

Issue Date: Last revised date:

16.01.2013 18.12.2015

Version: 1. 0 SDS No.: 000010021772 10/17

SDS_GB - 000010021772

Solubility in Water: 531 g/l (20 °C) Partition coefficient (n-octanol/water): < 1 Autoignition Temperature: 630 °C Decomposition Temperature: > 450 °C Viscosity

Kinematic viscosity: No data available. Dynamic viscosity: 0.255 mPa.s (-33.5 °C)

Explosive properties: Not applicable. Oxidising Properties: not applicable.

9.2 Other information: None.

Molecular weight: 17.03 g/mol (NH3) Minimum ignition energy: 680 mJ

SECTION 10: Stability and Reactivity

10.1 Reactivity: No reactivity hazard other than the effects described in sub-section below.

10.2 Chemical Stability: Stable under normal conditions.

10.3 Possibility of Hazardous

Reactions:

Can form a potentially explosive atmosphere in air. May react violently with oxidants.

10.4 Conditions to Avoid: Avoid moisture in the installation. Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.

10.5 Incompatible Materials: Air and oxidisers. Moisture. For material compatibility see latest version of ISO-11114. Reacts with water to form corrosive alkalis. May react violently with acids.

10.6 Hazardous Decomposition

Products:

Under normal conditions of storage and use, hazardous decomposition products should not be produced. If involved in a fire the following toxic and/or corrosive fumes may be produced by thermal decomposition: The following decomposition products may be produced: Nitrogen monoxide ; nitrogen dioxide

SECTION 11: Toxicological Information

General information: Inhalation of large amounts leads to bronchospasm, laryngeal oedema and pseudomembrane formation.

11.1 Information on toxicological effects

Acute toxicity - Oral

Product Based on available data, the classification criteria are not met.

ammonia, anhydrous

LD 50 (Rat): 350 mg/kg

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SAFETY DATA SHEET

Ammonia, anhydrous

Issue Date: Last revised date:

16.01.2013 18.12.2015

Version: 1. 0 SDS No.: 000010021772 11/17

SDS_GB - 000010021772

Acute toxicity - Dermal

Product Based on available data, the classification criteria are not met.

Acute toxicity - Inhalation

Product Toxic by inhalation. Toxic if inhaled.

ammonia, anhydrous

LC 50 (Rat, 1 h): 4000 ppm

Repeated dose toxicity

ammonia, anhydrous

LOAEL (Rat, Inhalation, 35 - 75 d): 175 mg/m3

Skin Corrosion/Irritation

Product Causes severe burns.

Serious Eye Damage/Eye Irritation

Product Causes serious eye damage.

Respiratory or Skin Sensitisation

Product Based on available data, the classification criteria are not met.

Germ Cell Mutagenicity

Product Based on available data, the classification criteria are not met.

Carcinogenicity

Product Based on available data, the classification criteria are not met.

Reproductive toxicity

Product Based on available data, the classification criteria are not met.

Specific Target Organ Toxicity - Single Exposure

Product Based on available data, the classification criteria are not met.

Specific Target Organ Toxicity - Repeated Exposure

Product Based on available data, the classification criteria are not met.

Aspiration Hazard

Product Not applicable to gases and gas mixtures..

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SAFETY DATA SHEET

Ammonia, anhydrous

Issue Date: Last revised date:

16.01.2013 18.12.2015

Version: 1. 0 SDS No.: 000010021772 12/17

SDS_GB - 000010021772

SECTION 12: Ecological Information

General information: Avoid release to the environment. Product is not allowed to be discharged into ground water or the aquatic environment.

12.1 Toxicity

Acute toxicity

Product Very toxic to aquatic life with long lasting effects.

Acute toxicity - Fish

ammonia, anhydrous

LC 50 (Fish, 96 h): 0.89 mg/l

Acute toxicity - Aquatic Invertebrates

ammonia, anhydrous

LC 50 (Water flea (Daphnia), 48 h): 101 mg/l

Toxicity to microorganisms

ammonia, anhydrous

Depending on local conditions and existing concentrations, disturbances in the biodegradation process of activated sludge are possible.

Toxicity to terrestrial organisms

ammonia, anhydrous

Study not necessary due to exposure considerations.

Chronic toxicity - Fish

ammonia, anhydrous

LOEC (Fish, 73 Days): 0.022 mg/l

Chronic toxicity - Aquatic Invertebrates

ammonia, anhydrous

NOEC (Water flea, 96 hrs): 0.79 mg/l

Toxicity to aquatic plants

ammonia, anhydrous

LC 50 (Algae, algal mat (Algae), 18 Days): 2,700 mg/l

12.2 Persistence and Degradability Product Not applicable to gases and gas mixtures..

Biodegradation

Inorganic The product is not readily biodegradable.

12.3 Bioaccumulative Potential Product The substance has no potential for bioaccumulation.

12.4 Mobility in Soil Product The substance has low mobility in soil.

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SAFETY DATA SHEET

Ammonia, anhydrous

Issue Date: Last revised date:

16.01.2013 18.12.2015

Version: 1. 0 SDS No.: 000010021772 13/17

SDS_GB - 000010021772

ammonia, anhydrous

Henry's Law Constant: 0.09028 MPa (25 °C)

12.5 Results of PBT and vPvB

assessment

Product Not classified as PBT or vPvB.

12.6 Other Adverse Effects:

Other Ecological Information

May cause pH changes in aqueous ecological systems. Depending on local conditions and existing concentrations, disturbances in the biodegradation process of activated sludge are possible.

SECTION 13: Disposal Considerations

13.1 Waste treatment methods

General information: Must not be discharged to atmosphere. Consult supplier for specific recommendations.

Disposal methods: Refer to the EIGA code of practice (Doc.30 "Disposal of Gases", downloadable at http://www.eiga.org) for more guidance on suitable disposal methods. Dispose of container via supplier only. Discharge, treatment, or disposal may be subject to national, state, or local laws. Toxic and corrosive gases formed during combustion should be scrubbed before discharge to atmosphere. Gas may be scrubbed in water. Gas may be scrubbed in sulphuric acid solution.

European Waste Codes

Container: 16 05 04*: gases in pressure containers (including halons) containing dangerous substances

SECTION 14: Transport Information

ADR 14.1 UN Number: UN 1005 14.2 UN Proper Shipping Name: AMMONIA, ANHYDROUS 14.3 Transport Hazard Class(es)

Class: 2 Label(s): 2.3, 8 Hazard No. (ADR): 268 Tunnel restriction code: (C/D)

Emergency Action Code: 2RE 14.4 Packing Group: – 14.5 Environmental hazards: Environmentally Hazardous 14.6 Special precautions for user: –

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SAFETY DATA SHEET

Ammonia, anhydrous

Issue Date: Last revised date:

16.01.2013 18.12.2015

Version: 1. 0 SDS No.: 000010021772 14/17

SDS_GB - 000010021772

RID 14.1 UN Number: UN 1005 14.2 UN Proper Shipping Name AMMONIA, ANHYDROUS 14.3 Transport Hazard Class(es)

Class: 2 Label(s): 2.3, 8

14.4 Packing Group: – 14.5 Environmental hazards: Environmentally Hazardous 14.6 Special precautions for user: –

IMDG

14.1 UN Number: UN 1005 14.2 UN Proper Shipping Name: AMMONIA, ANHYDROUS 14.3 Transport Hazard Class(es)

Class: 2.3 Label(s): 2.3, 8 EmS No.: F-C, S-U

14.3 Packing Group: – 14.5 Environmental hazards: not applicable 14.6 Special precautions for user: –

IATA

14.1 UN Number: UN 1005 14.2 Proper Shipping Name: Ammonia, anhydrous 14.3 Transport Hazard Class(es):

Class: 2.3 Label(s): –

14.4 Packing Group: – 14.5 Environmental hazards: Environmentally Hazardous 14.6 Special precautions for user: –

Other information Passenger and cargo aircraft: Forbidden. Cargo aircraft only: Forbidden.

14.7 Transport in bulk according to Annex II of MARPOL73/78 and the IBC Code: not applicable

Additional identification: Avoid transport on vehicles where the load space is not separated from

the driver's compartment. Ensure vehicle driver is aware of the potential hazards of the load and knows what to do in the event of an accident or an emergency. Before transporting product containers ensure that they are firmly secured. Ensure that the container valve is closed and not leaking. Container valve guards or caps should be in place. Ensure adequate air ventilation.

SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture:

EU Regulations

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SAFETY DATA SHEET

Ammonia, anhydrous

Issue Date: Last revised date:

16.01.2013 18.12.2015

Version: 1. 0 SDS No.: 000010021772 15/17

SDS_GB - 000010021772

Directive 96/61/EC: concerning integrated pollution prevention and control (IPPC): Article 15, European

Pollution Emission Registry (EPER):

Chemical name CAS-No. Concentration

ammonia, anhydrous

7664-41-7 100%

Directive 96/82/EC (Seveso II): on the control of major accident hazards involving dangerous substances:

Chemical name CAS-No. Concentration

ammonia, anhydrous

7664-41-7 100%

Directive 98/24/EC on the protection of workers from the risks related to chemical agents at work:

Chemical name CAS-No. Concentration

ammonia, anhydrous

7664-41-7 100%

National Regulations

Dangerous Substances and Explosive Atmospheres Regulations (DSEAR 2002 No. 2776). Management of Health and Safety at Work Regulations (1999 No. 3242). The Regulatory Reform (Fire Safety) Order 2005 (2005 No. 1541). Control of Substances Hazardous to Health Regulations (COSHH, 2002 No. 2677). Provision and Use of Work Equipment Regulations (PUWER, 1998 No. 2306). Personal Protective Equipment Regulations (1992 No. 2966). Control of Major Accident Hazards Regulations (COMAH, 2015 No. 483). Equipment and Protective Systems Intended for Use in Potentially Explosive Atmospheres Regulations (EPS, 1996 No. 192). Pressure Systems Safety Regulations (PSSR, 2000 No. 128). Only products that comply with the food regulations (EC) No. 1333/2008 and (EU) No. 231/2012 and are labelled as such may be used as food additives. This Safety Data Sheet has been produced to comply with Regulation (EU) 453/2010.

15.2 Chemical safety assessment: CSA has been carried out.

SECTION 16: Other Information

Revision Information: Not relevant.

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SAFETY DATA SHEET

Ammonia, anhydrous

Issue Date: Last revised date:

16.01.2013 18.12.2015

Version: 1. 0 SDS No.: 000010021772 16/17

SDS_GB - 000010021772

Key literature references and

sources for data:

Various sources of data have been used in the compilation of this SDS, they include but are not exclusive to: Agency for Toxic Substances and Diseases Registry (ATSDR) (http://www.atsdr.cdc.gov/). European Chemical Agency: Guidance on the Compilation of Safety Data Sheets. European Chemical Agency: Information on Registered Substances http://apps.echa.europa.eu/registered/registered-sub.aspx#search European Industrial Gases Association (EIGA) Doc. 169 Classification and Labelling guide. International Programme on Chemical Safety (http://www.inchem.org/) ISO 10156:2010 Gases and gas mixtures - Determination of fire potential and oxidizing ability for the selection of cylinder valve outlets. Matheson Gas Data Book, 7th Edition. National Institute for Standards and Technology (NIST) Standard Reference Database Number 69. The ESIS (European chemical Substances 5 Information System) platform of the former European Chemicals Bureau (ECB) ESIS (http://ecb.jrc.ec.europa.eu/esis/). The European Chemical Industry Council (CEFIC) ERICards. United States of America’s National Library of Medicine’s toxicology data network TOXNET (http://toxnet.nlm.nih.gov/index.html) Threshold Limit Values (TLV) from the American Conference of Governmental Industrial Hygienists (ACGIH). Substance specific information from suppliers. Details given in this document are believed to be correct at the time of publication. EH40 (as amended) Workplace exposure limits.

Wording of the R-phrases and H-statements in sections 2 and 3

H221 Flammable gas. H280 Contains gas under pressure; may explode if heated. H314 Causes severe skin burns and eye damage. H318 Causes serious eye damage. H331 Toxic if inhaled. H400 Very toxic to aquatic life. H411 Toxic to aquatic life with long lasting effects. R10 Flammable. R23 Toxic by inhalation. R34 Causes burns. R50 Very toxic to aquatic organisms.

Training information: Users of breathing apparatus must be trained. Ensure operators understand the

toxicity hazard.

Classification according to Regulation (EC) No 1272/2008 as amended.

Flam. Gas 2, H221 Press. Gas Liq. Gas, H280 Acute Tox. 3, H331 Skin Corr. 1B, H314 Eye Dam. 1, H318 Aquatic Acute 1, H400 Aquatic Chronic 2, H411

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SAFETY DATA SHEET

Ammonia, anhydrous

Issue Date: Last revised date:

16.01.2013 18.12.2015

Version: 1. 0 SDS No.: 000010021772 17/17

SDS_GB - 000010021772

Other information: Before using this product in any new process or experiment, a thorough material compatibility and safety study should be carried out. Ensure adequate air ventilation. Ensure all national/local regulations are observed. Whilst proper care has been taken in the preparation of this document, no liability for injury or damage resulting from its use can be accepted. Note: When the Product Name appears in the SDS header the decimal sign and its position comply with rules for the structure and drafting of international standards, and is a comma on the line. As an example 2,000 is two (to three decimal places) and not two thousand, whilst 1.000 is one thousand and not one (to three decimal places).

Last revised date: 18.12.2015 Disclaimer: This information is provided without warranty. The information is believed to be

correct. This information should be used to make an independent determination of the methods to safeguard workers and the environment.

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0PERSONAL PROTECTION E

REACTIVITY 0

HEALTH 1FLAMMABILITY 0 1

1

Asbury Graphite Mills, Inc. PO Box 144, 405 Old Main St. Asbury, NJ 08802 908-537-2155 Cummings – Moore Graphite Co. 1646 N. Green Ave. Detroit, MI 48209 313-841-1615 Anthracite Industries PO Box 112, Sunbury, PA 17801 570-286-2176 Southwestern Graphite PO Box 876, 2564 Hwy 12 DeQuincy, LA 70633 337-786-5905 Asbury Graphite of California 2855 Franklin Canyon Rd. Rodeo, CA 94572 510-799-3636

Material Safety Data Sheet (According regulation 1907/2006/EC and directives 67/548/EC and 1999/45/EC)

HMIS NFPA Flammability Health Reactivity Special Notice Section 1 – Identification of the Substance / Preparation, and of the Company Product Name/ Trade Name Natural Graphite: 85-98 Carbon Product Description Natural Graphite: 85-98 Carbon

Emergency Phone 1-800-255-3924 Information Phone 1-908-537-2155 Fax 1-908-537-2908 Date Prepared February 15, 2010

Manufacturer Asbury Carbons PO Box 144, 405 Old Main Street Asbury, NJ 08802

Preparer (optional) AVT Section 2 – Hazards Information Not Classified according EU regulations Powder/air mixtures can cause dust explosion (see chapter 9) Free Crystalline silica: Human Hazards: Free Cystalline Silica May Be Present. Silica Is An Inhalation Hazard When Present As Respirable Particulates. IARC Monograph Vol 68,1997 Conclude That There Is A Sufficient Evidence That Inhaled Crystalline Silica Causes Cancer In Humans. IARC Classification: Group 1

Section 3 – Composition / Information On Ingredients Hazardous Ingredients And Non Hazardous Ingredients Components CAS Number % Natural flake graphite 7782-42-5 100% Free crystalline silica (quartz) 14808-60-7 0.0-4.0% Section 4 – First Aid Measures Ingestion Natural graphite is not known to be toxic by ingestion. However, ingestion may cause digestive

system blockage. Skin Contact Wash with mild soap and warm water Eye Contact Rinse with tepid water until eyes are clear of particulates. Seek medical attention if irritation

persists. Inhalation Remove patient to particulate-free environment. Wear approved dust mask to avoid breathing

dust. Seek medical attention if irritation persists.

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Asbury Carbons MSDS: Natural Graphite 85-98C, February 15, 2010, Page 2

Section 5 – Fire Fighting Measures Natural graphite is not flammable under normal conditions Extinguishing Media Dry chemical extinguisher, water Protective Equipment Self contained air pack, gloves, safety goggles Special Hazards None Known NFP Rating 010 Section 6 – Accidental Release Measures Personal Precautions Dust mask, safety goggles, conventional gloves Methods for Cleaning Up: Conventional Sweep or vacuum. Avoid dusting conditions Section 7 – Handling and Storage Handling Conventional means to avoid dusting conditions. Natural graphite is a conductor of

electricity. Avoid contact between Natural graphite and electrical circuitry. Storage Store all carbonaceous materials in a dry location, away from oxidizing agents. Section 8 – Exposure Controls/ Personal Protection Control Parameters German or US Limits

Component CAS No. % ACGIH TWA Control Reference

Natural flake graphite 7782-42-5 100 2.0 mg/m3 3 mg/m3 for nuisance dust

Free crystalline silica (quartz) 14808-60-7 0.1-4.0% 0.025mg/m3 ACGIH Threshold Limit Values

Engineering Measures Use adequate dust collections to maintain dust levels below the control or recommended values.

Respiratory Protection Approved dust mask Eye Protection Conventional safety glasses or goggles. Skin Protection Conventional work gloves and clothing. Additional None Section 9 – Physical and Chemical Properties Colour: Gray to Black Material State Solid free flowing flakes or powder Odour None Boiling Point: 4827 C Melting Point Sublimates at 3652C Specific Gravity 2.26 Vapour Density Not applicable Vapor Pressure (mm Hg) NA % Volatile (By Wt.) 0-1% Solubility in Water Insoluble Evaporation Rate: Not applicable pH 6-8 Auto Ignition Above 500C Decomposition Temp Above 400C Dust Explosion class ST1=KST>0-200 bar.m/s Flash Point Not Applicable. When exposed to extremely high energy ignition sources fine

graphite and carbon powder can form explosive mixtures with air. Avoid contact between graphite or carbon dust clouds and high energy ignition sources.

Section 10 – Stability and Reactivity Stability Stable will not polymerize Conditions to Avoid Avoid contact with oxidizing agents Materials to Avoid Oxidizing agents Hazardous Decomposition Products

Carbon Dioxide (CO2) and carbon Monoxide (CO)

Section 11 – Toxicological Information

Toxicological information about natural graphite is not available. However, graphite is inert, insoluble and is not expected to present an ingestion hazard.

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Asbury Carbons MSDS: Natural Graphite 85-98C, February 15, 2010, Page 3

Section 12 – Ecological Information Assessment Natural graphite is inert and insoluble. To the best of our knowledge, Natural graphite

should not present any environmental hazards any more serious than any inert, insoluble dust or granular substance.

Section 13 – Disposal Considerations

Dispose of in a manner which conforms to local, state and Federal regulations.

Section 14 – Transport Information ICAO / IATA Shipping Name Natural Graphite Hazard Class Non Hazardous Subsidiary Class UN Number Packing Group None Transport Label Required No label required Additional Transport Info Technical Name (N.O.S.): Natural Graphite Section 15 – Regulatory Information EEC Marking and Labeling Symbol Not Known Risk Phases Graphite: R20 (harmful by inhalation), Silica: R49 (may cause cancer by inhalation) Safety Phases S14 (keep away from oxidizers), S22(do not breathe dust), S23 (avoid contact with

eyes), S39 (wear eye protection)

Warning : This product contains a chemical known to the state of California to cause cancer: Silica

Inventory Information: EEC EINECS: #231-995-3, Silica 238-878-4 US TSCA Yes Canada DSL Yes Section 16 – Other Information HMIS Rating 100E NFP Rating 110 Reason for Issue

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Fluka - 38040 Page 1 of 7

SIGMA-ALDRICH sigma-aldrich.com SAFETY DATA SHEET

according to Regulation (EC) No. 1907/2006 Version 6.0 Revision Date 31.03.2016

Print Date 10.11.2016 GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifiers Product name : Bromine concentrate

Product Number : 38040 Brand : Fluka REACH No. : A registration number is not available for this substance as the substance

or its uses are exempted from registration, the annual tonnage does not require a registration or the registration is envisaged for a later registration deadline.

1.2 Relevant identified uses of the substance or mixture and uses advised against

Identified uses : Laboratory chemicals, Manufacture of substances

1.3 Details of the supplier of the safety data sheet

Company : Sigma-Aldrich Chemical Pvt Limited Industrial Area, Anekal Taluka Plot No 12, 12 Bommasandra - Jigani Link Road 560100 BANGALORE INDIA

1.4 Emergency telephone number

Emergency Phone # : +91 98802 05043

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture

Classification according to Regulation (EC) No 1272/2008 Skin irritation (Category 2), H315 Eye irritation (Category 2), H319 Carcinogenicity (Category 1B), H350

For the full text of the H-Statements mentioned in this Section, see Section 16.

2.2 Label elements

Labelling according Regulation (EC) No 1272/2008 Pictogram

Signal word Danger Hazard statement(s) H315 Causes skin irritation. H319 Causes serious eye irritation. H350 May cause cancer. Precautionary statement(s) P201 Obtain special instructions before use.

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Fluka - 38040 Page 2 of 7

P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

P308 + P313 IF exposed or concerned: Get medical advice/ attention. Supplemental Hazard Statements

none

Restricted to professional users.

2.3 Other hazards This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

SECTION 3: Composition/information on ingredients

3.2 Mixtures Synonyms : Bromide bromate concentrate

Formula : Br<SB>2</> Molecular weight : 159.81 g/mol Hazardous ingredients according to Regulation (EC) No 1272/2008

Component Classification Concentration

Potassium bromide

CAS-No. EC-No.

7758-02-3 231-830-3

Eye Irrit. 2; H319 >= 10 - < 20 %

Potassium bromate

CAS-No. EC-No. Index-No.

7758-01-2 231-829-8 035-003-00-6

Ox. Sol. 1; Acute Tox. 3; Carc. 1B; H271, H301, H350

>= 1 - < 3 %

For the full text of the H-Statements mentioned in this Section, see Section 16.

SECTION 4: First aid measures

4.1 Description of first aid measures

General advice Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact Wash off with soap and plenty of water. Consult a physician.

In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

4.2 Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

4.3 Indication of any immediate medical attention and special treatment needed No data available

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Fluka - 38040 Page 3 of 7

SECTION 5: Firefighting measures

5.1 Extinguishing media

Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

5.2 Special hazards arising from the substance or mixture Hydrogen bromide gas, Potassium oxides

5.3 Advice for firefighters Wear self-contained breathing apparatus for firefighting if necessary.

5.4 Further information No data available

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

6.3 Methods and materials for containment and cleaning up Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.

6.4 Reference to other sections For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling Avoid contact with skin and eyes. Avoid formation of dust and aerosols.Avoid exposure - obtain special instructions before use. Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

hygroscopic Light sensitive. Store under inert gas. Storage class (TRGS 510): Combustible solids, toxic

7.3 Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

8.1 Control parameters

8.2 Exposure controls

Appropriate engineering controls Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

Personal protective equipment

Eye/face protection Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

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Fluka - 38040 Page 4 of 7

Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Body Protection Impervious clothing, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use (EN 143) respirator cartridges as a backup to engineering controls. If th full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Control of environmental exposure Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties

a) Appearance Form: powder Colour: white

b) Odour No data available

c) Odour Threshold No data available

d) pH No data available

e) Melting point/freezing point

No data available

f) Initial boiling point and boiling range

No data available

g) Flash point No data available

h) Evaporation rate No data available

i) Flammability (solid, gas) No data available

j) Upper/lower flammability or explosive limits

No data available

k) Vapour pressure No data available

l) Vapour density No data available

m) Relative density No data available

n) Water solubility No data available

o) Partition coefficient: n-octanol/water

No data available

p) Auto-ignition temperature

No data available

q) Decomposition temperature

No data available

r) Viscosity No data available

s) Explosive properties No data available

t) Oxidizing properties The substance or mixture is not classified as oxidizing.

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Fluka - 38040 Page 5 of 7

9.2 Other safety information No data available

SECTION 10: Stability and reactivity

10.1 Reactivity No data available

10.2 Chemical stability Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions No data available

10.4 Conditions to avoid No data available

10.5 Incompatible materials Strong reducing agents, Powdered metals

10.6 Hazardous decomposition products Hazardous decomposition products formed under fire conditions. - Hydrogen bromide gas, Potassium oxides In the event of fire: see section 5

SECTION 11: Toxicological information

11.1 Information on toxicological effects

Acute toxicity No data available

Skin corrosion/irritation No data available

Serious eye damage/eye irritation No data available

Respiratory or skin sensitisation No data available

Germ cell mutagenicity No data available

Carcinogenicity

IARC: 2B - Group 2B: Possibly carcinogenic to humans (Potassium bromate)

Reproductive toxicity No data available

Specific target organ toxicity - single exposure No data available

Specific target organ toxicity - repeated exposure No data available

Aspiration hazard No data available

Additional Information RTECS: Not available To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.

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Fluka - 38040 Page 6 of 7

SECTION 12: Ecological information

12.1 Toxicity No data available

12.2 Persistence and degradability No data available

12.3 Bioaccumulative potential No data available

12.4 Mobility in soil No data available

12.5 Results of PBT and vPvB assessment This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

12.6 Other adverse effects No data available

SECTION 13: Disposal considerations

13.1 Waste treatment methods

Product Offer surplus and non-recyclable solutions to a licensed disposal company. Dissolve or mix the material with a combustible solvent and burn in a chem scrubber.

Contaminated packaging Dispose of as unused product.

SECTION 14: Transport information

14.1 UN number ADR/RID: - IMDG: - IATA: -

14.2 UN proper shipping name ADR/RID: Not dangerous goods IMDG: Not dangerous goods IATA: Not dangerous goods

14.3 Transport hazard class(es) ADR/RID: - IMDG: - IATA: -

14.4 Packaging group ADR/RID: - IMDG: - IATA: -

14.5 Environmental hazards ADR/RID: no IMDG Marine pollutant: no IATA: no

14.6 Special precautions for user No data available

SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

15.2 Chemical safety assessment For this product a chemical safety assessment was not carried out

SECTION 16: Other information

Full text of H-Statements referred to under sections 2 and 3.

H271 May cause fire or explosion; strong oxidizer. H301 Toxic if swallowed.

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Fluka - 38040 Page 7 of 7

H315 Causes skin irritation. H319 Causes serious eye irritation. H350 May cause cancer.

Further information Copyright 2016 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

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p. 1

0 1 0

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Material Safety Data SheetCalcium acetate MSDS

Section 1: Chemical Product and Company Identification

Product Name: Calcium acetate

Catalog Codes: SLC1777, SLC3568

CAS#: 62-54-4

RTECS: AF7525000

TSCA: TSCA 8(b) inventory: Calcium acetate

CI#: Not available.

Synonym:

Chemical Name: Calcium Acetate

Chemical Formula: C4H6CaO4

Contact Information:

Sciencelab.com, Inc.14025 Smith Rd.Houston, Texas 77396

US Sales: 1-800-901-7247International Sales: 1-281-441-4400

Order Online: ScienceLab.com

CHEMTREC (24HR Emergency Telephone), call:1-800-424-9300

International CHEMTREC, call: 1-703-527-3887

For non-emergency assistance, call: 1-281-441-4400

Section 2: Composition and Information on Ingredients

Composition:

Name CAS # % by Weight

Calcium acetate 62-54-4 100

Toxicological Data on Ingredients: Not applicable.

Section 3: Hazards Identification

Potential Acute Health Effects: Slightly hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, ofinhalation.

Potential Chronic Health Effects:CARCINOGENIC EFFECTS: Not available. MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS: Not available.DEVELOPMENTAL TOXICITY: Not available. Repeated or prolonged exposure is not known to aggravate medical condition.

Section 4: First Aid Measures

Eye Contact:Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15minutes. Cold water may be used. Get medical attention if irritation occurs.

Skin Contact:

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p. 2

Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops. Cold watermay be used.

Serious Skin Contact: Not available.

Inhalation:If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medicalattention.

Serious Inhalation: Not available.

Ingestion:Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconsciousperson. If large quantities of this material are swallowed, call a physician immediately. Loosen tight clothing such as a collar,tie, belt or waistband.

Serious Ingestion: Not available.

Section 5: Fire and Explosion Data

Flammability of the Product: May be combustible at high temperature.

Auto-Ignition Temperature: Not available.

Flash Points: CLOSED CUP: Higher than 93.3°C (200°F).

Flammable Limits: Not available.

Products of Combustion:Products of combustion are carbon oxides (CO, CO2). Some metallic oxides. Products of Decompostion: acetone and calciumcarbonate

Fire Hazards in Presence of Various Substances: Slightly flammable to flammable in presence of heat.

Explosion Hazards in Presence of Various Substances:Risks of explosion of the product in presence of mechanical impact: Not available. Risks of explosion of the product inpresence of static discharge: Not available.

Fire Fighting Media and Instructions:SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use water spray, fog or foam. Do not use water jet.

Special Remarks on Fire Hazards: Not available.

Special Remarks on Explosion Hazards: Not available.

Section 6: Accidental Release Measures

Small Spill:Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water onthe contaminated surface and dispose of according to local and regional authority requirements.

Large Spill:Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on thecontaminated surface and allow to evacuate through the sanitary system.

Section 7: Handling and Storage

Precautions:Keep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk, evaporate the residue under afume hood. Ground all equipment containing material. Do not breathe dust. Keep away from incompatibles such as oxidizingagents, moisture.

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p. 3

Storage:Very Hygroscopic. Keep container tightly closed. Keep container in a cool, well-ventilated area. Do not store above 23°C(73.4°F).

Section 8: Exposure Controls/Personal Protection

Engineering Controls:Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommendedexposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminantsbelow the exposure limit.

Personal Protection: Safety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent.Gloves.

Personal Protection in Case of a Large Spill:Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoidinhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling thisproduct.

Exposure Limits: Not available.

Section 9: Physical and Chemical Properties

Physical state and appearance: Solid. (Crystals solid.)

Odor: Acetic acid. (Slight.)

Taste: Not available.

Molecular Weight: 158.17 g/mole

Color: White.

pH (1% soln/water): Not available.

Boiling Point: Not available.

Melting Point: Not available.

Critical Temperature: Not available.

Specific Gravity: 1.5 (Water = 1)

Vapor Pressure: Not applicable.

Vapor Density: Not available.

Volatility: Not available.

Odor Threshold: Not available.

Water/Oil Dist. Coeff.: Not available.

Ionicity (in Water): Not available.

Dispersion Properties: See solubility in water.

Solubility: Soluble in cold water.

Section 10: Stability and Reactivity Data

Stability: The product is stable.

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p. 4

Instability Temperature: Not available.

Conditions of Instability: Excess heat, moisture, incompatible materials.

Incompatibility with various substances: Reactive with oxidizing agents, moisture.

Corrosivity: Non-corrosive in presence of glass.

Special Remarks on Reactivity: Very hygroscopic.

Special Remarks on Corrosivity: Not available.

Polymerization: Will not occur.

Section 11: Toxicological Information

Routes of Entry: Inhalation. Ingestion.

Toxicity to Animals:LD50: Not available. LC50: Not available.

Chronic Effects on Humans: Not available.

Other Toxic Effects on Humans: Slightly hazardous in case of skin contact (irritant), of ingestion, of inhalation.

Special Remarks on Toxicity to Animals: Not available.

Special Remarks on Chronic Effects on Humans: May affect genetic material.

Special Remarks on other Toxic Effects on Humans:Acute Potential Heath Effects: Skin: May cause skin irritation. Eyes: Dust may cause eye irritation. Inhalation: Dust may causerespiratory tract irritation. Ingestion: May cause gastrointestinal (digestive) tract irritation. May affect brain. The toxicologicalproperities have not been fully investigated.

Section 12: Ecological Information

Ecotoxicity: Not available.

BOD5 and COD: Not available.

Products of Biodegradation:Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise.

Toxicity of the Products of Biodegradation: The product itself and its products of degradation are not toxic.

Special Remarks on the Products of Biodegradation: Calcium acetate is biogradeable

Section 13: Disposal Considerations

Waste Disposal:Waste must be disposed of in accordance with federal, state and local environmental control regulations.

Section 14: Transport Information

DOT Classification: Not a DOT controlled material (United States).

Identification: Not applicable.

Special Provisions for Transport: Not applicable.

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p. 5

Section 15: Other Regulatory Information

Federal and State Regulations: TSCA 8(b) inventory: Calcium acetate

Other Regulations: EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances.

Other Classifications:

WHMIS (Canada): Not controlled under WHMIS (Canada).

DSCL (EEC):This product is not classified according to the EU regulations. S24/25- Avoid contact with skin and eyes.

HMIS (U.S.A.):

Health Hazard: 1

Fire Hazard: 1

Reactivity: 0

Personal Protection: E

National Fire Protection Association (U.S.A.):

Health: 1

Flammability: 0

Reactivity: 0

Specific hazard:

Protective Equipment:Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Safety glasses.

Section 16: Other Information

References: Not available.

Other Special Considerations: Not available.

Created: 10/09/2005 04:30 PM

Last Updated: 05/21/2013 12:00 PM

The information above is believed to be accurate and represents the best information currently available to us. However, wemake no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assumeno liability resulting from its use. Users should make their own investigations to determine the suitability of the information fortheir particular purposes. In no event shall ScienceLab.com be liable for any claims, losses, or damages of any third party or forlost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if ScienceLab.comhas been advised of the possibility of such damages.

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Material Safety Data Sheet

Celite®

Section 1 - Chemical Product and Company Identification

MSDS Name: Celite®

Catalog Numbers: 17346-0000, 17346-0100, 17346-0250

Synonyms: Infusorial earth; Diatomite; Diatomaceous earth

Company Identification:

Acros Organics BVBA

Janssen Pharmaceuticalaan 3a

2440 Geel, Belgium

Company Identification: (USA)

Acros Organics

One Reagent Lane

Fair Lawn, NJ 07410

For information in the US, call: 800-ACROS-01

For information in Europe, call: +32 14 57 52 11

Emergency Number, Europe: +32 14 57 52 99

Emergency Number US: 201-796-7100

CHEMTREC Phone Number, US: 800-424-9300

CHEMTREC Phone Number, Europe: 703-527-3887

Section 2 - Composition, Information on Ingredients

CAS# Chemical Name: % EINECS#

61790-53-2 Celite® unlisted

Hazard Symbols: XN

Risk Phrases: 36/37 48/20

Section 3 - Hazards Identification

EMERGENCY OVERVIEW

Irritating to eyes and respiratory system. Harmful : danger of serious damage to health by

prolonged exposure through inhalation.

Potential Health Effects

Eye: Dust may cause mechanical irritation.

Skin: May cause skin irritation.

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Ingestion: May cause irritation of the digestive tract.

Inhalation: Causes respiratory tract irritation. Contains crystalline silica which may lead to

respiratory abnormalities and silicosis.

Chronic: Chronic exposure may cause lung damage.

Section 4 - First Aid Measures

Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting

the upper and lower eyelids. Get medical aid.

Skin:

Get medical aid. Flush skin with plenty of water for at least 15 minutes while

removing contaminated clothing and shoes. Flush skin with plenty of soap

and water.

Ingestion: Get medical aid. Wash mouth out with water.

Inhalation:

Remove from exposure and move to fresh air immediately. If not breathing,

give artificial respiration. If breathing is difficult, give oxygen. Get medical

aid.

Notes to

Physician:

Section 5 - Fire Fighting Measures

General

Information:

As in any fire, wear a self-contained breathing apparatus in pressure-

demand, MSHA/NIOSH (approved or equivalent), and full protective gear.

Substance is noncombustible.

Extinguishing

Media: Use agent most appropriate to extinguish fire.

Section 6 - Accidental Release Measures

General

Information: Use proper personal protective equipment as indicated in Section 8.

Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container.

Avoid generating dusty conditions.

Section 7 - Handling and Storage

Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with eyes, skin, and

clothing. Avoid ingestion and inhalation.

Storage: Store in a cool, dry place. Store in a tightly closed container.

Section 8 - Exposure Controls, Personal Protection

Engineering Controls:

Use adequate ventilation to keep airborne concentrations low.

Exposure Limits

CAS# 61790-53-2:

United Kingdom, WEL - TWA: 1.2 mg/m3 TWA (respirable dust)

United Kingdom, WEL - STEL: 3.6 mg/m3 STEL (respirable

dust)

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Belgium - TWA: 3 mg/m3 VLE (respirable fraction); 10 mg/m3

VLE (inhalable fraction)

Germany: 4 mg/m3 TWA (inhalable fraction)

Malaysia: 10 mg/m3 TWA (particulate matter containing no

asbestos and <1% crystalline sili

Russia: 3 mg/m3 STEL (total aerosol)

Spain: 10 mg/m3 VLA-ED (inhalable fraction, this value is for the

particulated matter t

Personal Protective Equipment

Eyes: Wear chemical splash goggles.

Skin: Wear appropriate protective gloves to prevent skin exposure.

Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators:

Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European

Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149

approved respirator if exposure limits are exceeded or if irritation or other

symptoms are experienced.

Section 9 - Physical and Chemical Properties

Physical State: Powder

Color: white - grey - pink

Odor: Not available

pH: Not available

Vapor Pressure: Not available

Viscosity: Not available

Boiling Point: Not available

Freezing/Melting Point: Not available

Autoignition Temperature: Not available

Flash Point: Not available

Explosion Limits: Lower: Not available

Explosion Limits: Upper: Not available

Decomposition Temperature: Not available

Solubility in water: Insoluble

Specific Gravity/Density:

Molecular Formula: O2Si

Molecular Weight: 60.08

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Section 10 - Stability and Reactivity

Chemical Stability: Stable under normal temperatures and pressures.

Conditions to Avoid: Incompatible materials, moisture.

Incompatibilities with Other Materials Strong oxidizing agents, strong acids.

Hazardous Decomposition Products Oxides of silicon.

Hazardous Polymerization Has not been reported.

Section 11 - Toxicological Information

RTECS#: CAS# 61790-53-2: VV7311000

LD50/LC50: RTECS: Not available.

Carcinogenicity: Celite® - IARC: Group 3 (not classifiable)

Other: The toxicological properties have not been fully investigated. See actual

entry in RTECS for complete information.

Section 12 - Ecological Information

Not available

Section 13 - Disposal Considerations

Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - Transport Information

IATA IMO RID/ADR

Shipping Name: Not regulated. Not regulated. Not regulated.

Hazard Class:

UN Number:

Packing Group:

Section 15 - Regulatory Information

European/International Regulations

European Labeling in Accordance with EC Directives

Hazard Symbols: XN

Risk Phrases:

R 36/37 Irritating to eyes and respiratory system.

R 48/20 Harmful : danger of serious damage to health by prolonged exposure

through inhalation.

Safety Phrases:

S 26 In case of contact with eyes, rinse immediately with plenty of water and

seek medical advice.

S 39 Wear eye/face protection.

WGK (Water Danger/Protection)

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CAS# 61790-53-2: Not available

Canada

CAS# 61790-53-2 is listed on Canada's NDSL List

</ TD>

US Federal

TSCA

CAS# 61790-53-2 is listed on the TSCA Inventory.

Section 16 - Other Information

MSDS Creation Date: 7/16/1996

Revision #1 Date 6/06/2005

Revisions were made in Sections: General revision.

The information above is believed to be accurate and represents the best

information currently available to us. However, we make no warranty of

merchantibility or any other warranty, express or implied, with respect to

such information, and we assume no liability resulting from its use. Users

should make their own investigations to determine the suitability of the

information for their particular purposes. In no event shall the company be

liable for any claims, losses, or damages of any third party or for lost profits

or any special, indirect, incidental, consequential, or exemplary damages

howsoever arising, even if the company has been advised of the possibility of

such damages.

--------------------------------------------------------------------------------

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Sigma-Aldrich - 288306 Page 1 of 7

SIGMA-ALDRICH sigma-aldrich.com SAFETY DATA SHEET

according to Regulation (EC) No. 1907/2006 Version 6.0 Revision Date 31.03.2016

Print Date 10.11.2016 GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifiers Product name : Chloroform

Product Number : 288306 Brand : Sigma-Aldrich REACH No. : A registration number is not available for this substance as the substance

or its uses are exempted from registration, the annual tonnage does not require a registration or the registration is envisaged for a later registration deadline.

CAS-No. : 67-66-3

1.2 Relevant identified uses of the substance or mixture and uses advised against

Identified uses : Laboratory chemicals, Manufacture of substances

1.3 Details of the supplier of the safety data sheet

Company : Sigma-Aldrich Chemical Pvt Limited Industrial Area, Anekal Taluka Plot No 12, 12 Bommasandra - Jigani Link Road 560100 BANGALORE INDIA

1.4 Emergency telephone number

Emergency Phone # : +91 98802 05043

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture

Classification according to Regulation (EC) No 1272/2008 Acute toxicity, Oral (Category 4), H302 Acute toxicity, Inhalation (Category 3), H331 Skin irritation (Category 2), H315 Eye irritation (Category 2), H319 Carcinogenicity (Category 2), H351 Reproductive toxicity (Category 2), H361d Specific target organ toxicity - single exposure (Category 3), Central nervous system, H336 Specific target organ toxicity - repeated exposure (Category 1), H372

For the full text of the H-Statements mentioned in this Section, see Section 16.

2.2 Label elements

Labelling according Regulation (EC) No 1272/2008 Pictogram

Signal word Danger

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Sigma-Aldrich - 288306 Page 2 of 7

Hazard statement(s) H302 Harmful if swallowed. H315 Causes skin irritation. H319 Causes serious eye irritation. H331 Toxic if inhaled. H336 May cause drowsiness or dizziness. H351 Suspected of causing cancer. H361d Suspected of damaging the unborn child. H372 Causes damage to organs through prolonged or repeated exposure. Precautionary statement(s) P201 Obtain special instructions before use. P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P304 + P340 + P311 IF INHALED: Remove person to fresh air and keep comfortable for

breathing. Call a POISON CENTER/doctor. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove

contact lenses, if present and easy to do. Continue rinsing. P308 + P313 IF exposed or concerned: Get medical advice/ attention. P403 + P233 Store in a well-ventilated place. Keep container tightly closed. Supplemental Hazard Statements

none

2.3 Other hazards This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

SECTION 3: Composition/information on ingredients

3.2 Mixtures Synonyms : Trichloromethane

Methylidyne trichloride

Formula : CHCl<SB>3</> Molecular weight : 119.38 g/mol Hazardous ingredients according to Regulation (EC) No 1272/2008

Component Classification Concentration

Chloroform

CAS-No. EC-No. Index-No.

67-66-3 200-663-8 602-006-00-4

Acute Tox. 4; Acute Tox. 3; Skin Irrit. 2; Eye Irrit. 2; Carc. 2; Repr. 2; STOT SE 3; STOT RE 1; H302, H331, H315, H319, H351, H361d, H336, H372

>= 90 - <= 100 %

For the full text of the H-Statements mentioned in this Section, see Section 16.

SECTION 4: First aid measures

4.1 Description of first aid measures

General advice Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician.

In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

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Sigma-Aldrich - 288306 Page 3 of 7

If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

4.2 Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

4.3 Indication of any immediate medical attention and special treatment needed No data available

SECTION 5: Firefighting measures

5.1 Extinguishing media

Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

5.2 Special hazards arising from the substance or mixture Carbon oxides, Hydrogen chloride gas

5.3 Advice for firefighters Wear self-contained breathing apparatus for firefighting if necessary.

5.4 Further information No data available

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures Wear respiratory protection. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. For personal protection see section 8.

6.2 Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

6.3 Methods and materials for containment and cleaning up Soak up with inert absorbent material and dispose of as hazardous waste. Keep in suitable, closed containers for disposal.

6.4 Reference to other sections For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling Avoid contact with skin and eyes. Avoid inhalation of vapour or mist. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Storage class (TRGS 510): Non Combustible Liquids

7.3 Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

8.1 Control parameters

8.2 Exposure controls

Appropriate engineering controls Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product.

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Sigma-Aldrich - 288306 Page 4 of 7

Personal protective equipment

Eye/face protection Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Full contact Material: Fluorinated rubber Minimum layer thickness: 0.7 mm Break through time: 480 min Material tested:Vitoject® (KCL 890 / Aldrich Z677698, Size M) Splash contact Material: Fluorinated rubber Minimum layer thickness: 0.7 mm Break through time: 480 min Material tested:Vitoject® (KCL 890 / Aldrich Z677698, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail [email protected], test method: EN374 If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industria situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario. Body Protection Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use (US) or type AXBEK (EN 14387) respirator cartridges as a backup to engine protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Control of environmental exposure Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties

a) Appearance Form: liquid, clear Colour: colourless

b) Odour No data available

c) Odour Threshold No data available

d) pH No data available

e) Melting point/freezing point

Melting point/range: -63 °C - lit.

f) Initial boiling point and boiling range

60.5 - 61.5 °C - lit.

g) Flash point No data available

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Sigma-Aldrich - 288306 Page 5 of 7

h) Evaporation rate No data available

i) Flammability (solid, gas) No data available

j) Upper/lower flammability or explosive limits

No data available

k) Vapour pressure 160.0 mmHg at 20.0 °C

l) Vapour density No data available

m) Relative density 1.492 g/mL at 25 °C1.48 g/mL at 25 °C

n) Water solubility No data available

o) Partition coefficient: n-octanol/water

log Pow: 1.97

p) Auto-ignition temperature

No data available

q) Decomposition temperature

No data available

r) Viscosity No data available

s) Explosive properties No data available

t) Oxidizing properties No data available

9.2 Other safety information

Surface tension 27.1 mN/m at 20.0 °C

SECTION 10: Stability and reactivity

10.1 Reactivity No data available

10.2 Chemical stability Stable under recommended storage conditions. Contains the following stabiliser(s): (>=0.5 - <=1 %)

10.3 Possibility of hazardous reactions No data available

10.4 Conditions to avoid No data available

10.5 Incompatible materials Strong oxidizing agents, Strong bases, Magnesium, Sodium/sodium oxides, Lithium

10.6 Hazardous decomposition products Hazardous decomposition products formed under fire conditions. - Carbon oxides, Hydrogen chloride gas Other decomposition products - No data available In the event of fire: see section 5

SECTION 11: Toxicological information

11.1 Information on toxicological effects

Acute toxicity No data available

Skin corrosion/irritation No data available

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Sigma-Aldrich - 288306 Page 6 of 7

Serious eye damage/eye irritation No data available

Respiratory or skin sensitisation No data available

Germ cell mutagenicity No data available

Carcinogenicity

IARC: 2B - Group 2B: Possibly carcinogenic to humans (Chloroform)

Reproductive toxicity No data available

Specific target organ toxicity - single exposure No data available

Specific target organ toxicity - repeated exposure No data available

Aspiration hazard No data available

Additional Information RTECS: Not available To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.

SECTION 12: Ecological information

12.1 Toxicity No data available

12.2 Persistence and degradability No data available

12.3 Bioaccumulative potential No data available

12.4 Mobility in soil No data available

12.5 Results of PBT and vPvB assessment This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

12.6 Other adverse effects Harmful to aquatic life.

SECTION 13: Disposal considerations

13.1 Waste treatment methods

Product Offer surplus and non-recyclable solutions to a licensed disposal company.

Contaminated packaging Dispose of as unused product.

SECTION 14: Transport information

14.1 UN number ADR/RID: 1888 IMDG: 1888 IATA: 1888

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Sigma-Aldrich - 288306 Page 7 of 7

14.2 UN proper shipping name ADR/RID: CHLOROFORM IMDG: CHLOROFORM IATA: Chloroform

14.3 Transport hazard class(es) ADR/RID: 6.1 IMDG: 6.1 IATA: 6.1

14.4 Packaging group ADR/RID: III IMDG: III IATA: III

14.5 Environmental hazards ADR/RID: no IMDG Marine pollutant: no IATA: no

14.6 Special precautions for user No data available

SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

15.2 Chemical safety assessment For this product a chemical safety assessment was not carried out

SECTION 16: Other information

Full text of H-Statements referred to under sections 2 and 3.

H302 Harmful if swallowed. H315 Causes skin irritation. H319 Causes serious eye irritation. H331 Toxic if inhaled. H336 May cause drowsiness or dizziness. H351 Suspected of causing cancer. H361d Suspected of damaging the unborn child. H372 Causes damage to organs through prolonged or repeated exposure.

Further information Copyright 2016 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

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Aldrich - 675644 Page 1 of 8

SIGMA-ALDRICH sigma-aldrich.com SAFETY DATA SHEET

according to Regulation (EC) No. 1907/2006 Version 6.1 Revision Date 15.07.2016

Print Date 10.11.2016 GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifiers Product name : Chromium(VI) oxide

Product Number : 675644 Brand : Aldrich Index-No. : 024-001-00-0 REACH No. : A registration number is not available for this substance as the substance

or its uses are exempted from registration, the annual tonnage does not require a registration or the registration is envisaged for a later registration deadline.

CAS-No. : 1333-82-0

1.2 Relevant identified uses of the substance or mixture and uses advised against

Identified uses : Laboratory chemicals, Manufacture of substances

1.3 Details of the supplier of the safety data sheet

Company : Sigma-Aldrich Chemical Pvt Limited Industrial Area, Anekal Taluka Plot No 12, 12 Bommasandra - Jigani Link Road 560100 BANGALORE INDIA

1.4 Emergency telephone number

Emergency Phone # : +91 98802 05043

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture

Classification according to Regulation (EC) No 1272/2008 Oxidizing solids (Category 1), H271 Acute toxicity, Oral (Category 3), H301 Acute toxicity, Inhalation (Category 2), H330 Acute toxicity, Dermal (Category 3), H311 Skin corrosion (Category 1A), H314 Respiratory sensitisation (Category 1), H334 Skin sensitisation (Category 1), H317 Germ cell mutagenicity (Category 1B), H340 Carcinogenicity (Category 1A), H350 Reproductive toxicity (Category 2), H361f Specific target organ toxicity - repeated exposure (Category 1), H372 Acute aquatic toxicity (Category 1), H400 Chronic aquatic toxicity (Category 1), H410

For the full text of the H-Statements mentioned in this Section, see Section 16.

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Aldrich - 675644 Page 2 of 8

2.2 Label elements

Labelling according Regulation (EC) No 1272/2008 Pictogram

Signal word Danger Hazard statement(s) H271 May cause fire or explosion; strong oxidizer. H301 + H311 Toxic if swallowed or in contact with skin H314 Causes severe skin burns and eye damage. H317 May cause an allergic skin reaction. H330 Fatal if inhaled. H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled. H340 May cause genetic defects. H350 May cause cancer. H361f Suspected of damaging fertility. H372 Causes damage to organs through prolonged or repeated exposure. H410 Very toxic to aquatic life with long lasting effects. Precautionary statement(s) P201 Obtain special instructions before use. P210 Keep away from heat, hot surfaces, sparks, open flames and other

ignition sources. No smoking. P260 Do not breathe dust/ fume/ gas/ mist/ vapours/ spray. P280 Wear protective gloves/ protective clothing/ eye protection/ face

protection. P284 Wear respiratory protection. P301 + P310 + P330 IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse

mouth. P303 + P361 + P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing.

Rinse skin with water/shower. P304 + P340 + P310 IF INHALED: Remove person to fresh air and keep comfortable for

breathing. Immediately call a POISON CENTER/doctor. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove

contact lenses, if present and easy to do. Continue rinsing. P308 + P313 IF exposed or concerned: Get medical advice/ attention. P371 + P380 + P375 In case of major fire and large quantities: Evacuate area. Fight fire

remotely due to the risk of explosion. P403 + P233 Store in a well-ventilated place. Keep container tightly closed. Supplemental Hazard Statements

none

Restricted to professional users.

2.3 Other hazards This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

SECTION 3: Composition/information on ingredients

3.1 Substances Synonyms : Chromic anhydride

Formula : CrO<SB>3</> Molecular weight : 99.99 g/mol CAS-No. : 1333-82-0 EC-No. : 215-607-8 Index-No. : 024-001-00-0 Hazardous ingredients according to Regulation (EC) No 1272/2008

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Aldrich - 675644 Page 3 of 8

Component Classification Concentration

Chromium (VI) oxide Included in the Candidate List of Substances of Very High Concern (SVHC) according to Regulation (EC) No. 1907/2006 (REACH)

CAS-No. EC-No. Index-No.

1333-82-0 215-607-8 024-001-00-0

Ox. Sol. 1; Acute Tox. 3; Acute Tox. 2; Acute Tox. 3; Skin Corr. 1A; Resp. Sens. 1; Skin Sens. 1; Muta. 1B; Carc. 1A; Repr. 2; STOT RE 1; Aquatic Acute 1; Aquatic Chronic 1; H271, H301, H330, H311, H314, H334, H317, H340, H350, H361f, H372, H400, H410 Concentration limits: >= 1 %: STOT SE 3, H335;

M-Factor - Aquatic Acute: 10

<= 100 %

For the full text of the H-Statements mentioned in this Section, see Section 16.

SECTION 4: First aid measures

4.1 Description of first aid measures

General advice Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact Take off contaminated clothing and shoes immediately. Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician.

In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

4.2 Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

4.3 Indication of any immediate medical attention and special treatment needed No data available

SECTION 5: Firefighting measures

5.1 Extinguishing media

Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

5.2 Special hazards arising from the substance or mixture Chromium oxides

5.3 Advice for firefighters Wear self-contained breathing apparatus for firefighting if necessary.

5.4 Further information Use water spray to cool unopened containers.

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SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures Wear respiratory protection. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

6.3 Methods and materials for containment and cleaning up Sweep up and shovel.\'20 Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations (see section 13). Keep in suitable, closed containers for disposal.

6.4 Reference to other sections For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling Avoid contact with skin and eyes. Avoid formation of dust and aerosols.Avoid exposure - obtain special instructions before use. Provide appropriate exhaust ventilation at places where dust is formed.Keep away from sources of ignition - No smoking. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

hygroscopic Heat sensitive. Storage class (TRGS 510): Strongly oxidizing hazardous materials

7.3 Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

8.1 Control parameters

8.2 Exposure controls

Appropriate engineering controls Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product.

Personal protective equipment

Eye/face protection Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Full contact Material: Nitrile rubber Minimum layer thickness: 0.11 mm Break through time: 480 min

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Aldrich - 675644 Page 5 of 8

Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M) Splash contact Material: Nitrile rubber Minimum layer thickness: 0.11 mm Break through time: 480 min Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail [email protected], test method: EN374 If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industria situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario. Body Protection Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use (EN 143) respirator cartridges as a backup to engineering controls. If th full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Control of environmental exposure Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties

a) Appearance Form: powder Colour: violet

b) Odour No data available

c) Odour Threshold No data available

d) pH No data available

e) Melting point/freezing point

Melting point/range: 196 °C - dec.

f) Initial boiling point and boiling range

No data available

g) Flash point Not applicable

h) Evaporation rate No data available

i) Flammability (solid, gas) No data available

j) Upper/lower flammability or explosive limits

No data available

k) Vapour pressure No data available

l) Vapour density No data available

m) Relative density 2.700 g/cm3

n) Water solubility 1.667 g/l - soluble

o) Partition coefficient: n-octanol/water

No data available

p) Auto-ignition temperature

No data available

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Aldrich - 675644 Page 6 of 8

q) Decomposition temperature

No data available

r) Viscosity No data available

s) Explosive properties No data available

t) Oxidizing properties The substance or mixture is classified as oxidizing with the category 1.

9.2 Other safety information No data available

SECTION 10: Stability and reactivity

10.1 Reactivity No data available

10.2 Chemical stability Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions No data available

10.4 Conditions to avoid Heat Avoid moisture.

10.5 Incompatible materials Organic materials, Phosphorus, Powdered metals

10.6 Hazardous decomposition products Hazardous decomposition products formed under fire conditions. - Chromium oxides Other decomposition products - No data available In the event of fire: see section 5

SECTION 11: Toxicological information

11.1 Information on toxicological effects

Acute toxicity LD50 Oral - Rat - male and female - 52 mg/kg(Chromium (VI) oxide) (OECD Test Guideline 401) LC50 Inhalation - Rat - male - 4 h - 217 mg/m3(Chromium (VI) oxide) LD50 Dermal - Rabbit - male and female - 57 mg/kg(Chromium (VI) oxide) (OECD Test Guideline 402)

Skin corrosion/irritation Skin - Rabbit(Chromium (VI) oxide) Result: Corrosive - 24 h

Serious eye damage/eye irritation Eyes - Rabbit(Chromium (VI) oxide) Result: Corrosive to eyes

Respiratory or skin sensitisation No data available(Chromium (VI) oxide)

Germ cell mutagenicity May alter genetic material.(Chromium (VI) oxide) In vivo tests showed mutagenic effects(Chromium (VI) oxide)

Carcinogenicity This is or contains a component that has been reported to be carcinogenic classification.(Chromium (VI) oxide) Human carcinogen.(Chromium (VI) oxide)

IARC: 1 - Group 1: Carcinogenic to humans (Chromium (VI) oxide)

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Aldrich - 675644 Page 7 of 8

Reproductive toxicity Suspected human reproductive toxicant(Chromium (VI) oxide)

May cause reproductive disorders.(Chromium (VI) oxide)

Specific target organ toxicity - single exposure No data available(Chromium (VI) oxide)

Specific target organ toxicity - repeated exposure No data available

Aspiration hazard No data available(Chromium (VI) oxide)

Additional Information RTECS: GB6650000 Material is extremely destructive to tissue of the mucous membranes and upper respiratory tract, eyes, and skin., Cough, Shortness of breath, Headache, Nausea(Chromium (VI) oxide)

SECTION 12: Ecological information

12.1 Toxicity Toxicity to fish LC50 - Tilapia mossambica - 21.05 - 141.38 mg/l - 96.0 h(Chromium (VI)

oxide) LC0 - Leuciscus idus (Golden orfe) - 100 mg/l - 48.0 h(Chromium (VI) oxide) Toxicity to daphnia and other aquatic invertebrates

EC50 - Daphnia magna (Water flea) - 0.8 mg/l - 48 h(Chromium (VI) oxide)

12.2 Persistence and degradability No data available

12.3 Bioaccumulative potential No data available

12.4 Mobility in soil No data available(Chromium (VI) oxide)

12.5 Results of PBT and vPvB assessment This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

12.6 Other adverse effects Very toxic to aquatic life with long lasting effects.

SECTION 13: Disposal considerations

13.1 Waste treatment methods

Product Burn in a chemical incinerator equipped with an afterburner and scrubber b highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company.

Contaminated packaging Dispose of as unused product.

SECTION 14: Transport information

14.1 UN number ADR/RID: 1463 IMDG: 1463 IATA: 1463

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Aldrich - 675644 Page 8 of 8

14.2 UN proper shipping name ADR/RID: CHROMIUM TRIOXIDE, ANHYDROUS IMDG: CHROMIUM TRIOXIDE, ANHYDROUS IATA: Chromium trioxide, anhydrous

14.3 Transport hazard class(es) ADR/RID: 5.1 (6.1, 8) IMDG: 5.1 (6.1, 8) IATA: 5.1 (6.1, 8)

14.4 Packaging group ADR/RID: II IMDG: II IATA: II

14.5 Environmental hazards ADR/RID: no IMDG Marine pollutant: no IATA: no

14.6 Special precautions for user No data available

SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

Authorisations and/or restrictions on use 15.2 Chemical safety assessment

For this product a chemical safety assessment was not carried out

SECTION 16: Other information

Full text of H-Statements referred to under sections 2 and 3.

H271 May cause fire or explosion; strong oxidizer. H301 Toxic if swallowed. H301 + H311 Toxic if swallowed or in contact with skin H311 Toxic in contact with skin. H314 Causes severe skin burns and eye damage. H317 May cause an allergic skin reaction. H330 Fatal if inhaled. H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled. H335 May cause respiratory irritation. H340 May cause genetic defects. H350 May cause cancer. H361f Suspected of damaging fertility. H372 Causes damage to organs through prolonged or repeated exposure. H400 Very toxic to aquatic life. H410 Very toxic to aquatic life with long lasting effects.

Further information Copyright 2016 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

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Sigma-Aldrich - 251275 Page 1 of 7

SIGMA-ALDRICH sigma-aldrich.com SAFETY DATA SHEET

according to Regulation (EC) No. 1907/2006 Version 6.0 Revision Date 30.03.2016

Print Date 10.11.2016 GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifiers Product name : Citric acid

Product Number : 251275 Brand : Sigma-Aldrich REACH No. : A registration number is not available for this substance as the substance

or its uses are exempted from registration, the annual tonnage does not require a registration or the registration is envisaged for a later registration deadline.

CAS-No. : 77-92-9

1.2 Relevant identified uses of the substance or mixture and uses advised against

Identified uses : Laboratory chemicals, Manufacture of substances

1.3 Details of the supplier of the safety data sheet

Company : Sigma-Aldrich Chemical Pvt Limited Industrial Area, Anekal Taluka Plot No 12, 12 Bommasandra - Jigani Link Road 560100 BANGALORE INDIA

1.4 Emergency telephone number

Emergency Phone # : +91 98802 05043

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture

Classification according to Regulation (EC) No 1272/2008 Eye irritation (Category 2), H319

For the full text of the H-Statements mentioned in this Section, see Section 16.

2.2 Label elements

Labelling according Regulation (EC) No 1272/2008 Pictogram

Signal word Warning Hazard statement(s) H319 Causes serious eye irritation. Precautionary statement(s) P280 Wear eye protection/ face protection. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove

contact lenses, if present and easy to do. Continue rinsing. P337 + P313 If eye irritation persists: Get medical advice/ attention.

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Sigma-Aldrich - 251275 Page 2 of 7

Supplemental Hazard Statements

none

2.3 Other hazards This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

SECTION 3: Composition/information on ingredients

3.1 Substances Formula : C6H8O7

Molecular weight : 192.12 g/mol CAS-No. : 77-92-9 EC-No. : 201-069-1 Hazardous ingredients according to Regulation (EC) No 1272/2008

Component Classification Concentration

Citric acid

CAS-No. EC-No.

77-92-9 201-069-1

Eye Irrit. 2; H319 <= 100 %

For the full text of the H-Statements mentioned in this Section, see Section 16.

SECTION 4: First aid measures

4.1 Description of first aid measures

General advice Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact Wash off with soap and plenty of water. Consult a physician.

In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

4.2 Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

4.3 Indication of any immediate medical attention and special treatment needed No data available

SECTION 5: Firefighting measures

5.1 Extinguishing media

Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

5.2 Special hazards arising from the substance or mixture Carbon oxides

5.3 Advice for firefighters Wear self-contained breathing apparatus for firefighting if necessary.

5.4 Further information No data available

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Sigma-Aldrich - 251275 Page 3 of 7

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions Do not let product enter drains.

6.3 Methods and materials for containment and cleaning up Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.

6.4 Reference to other sections For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Non Combustible Solids

7.3 Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

8.1 Control parameters

8.2 Exposure controls

Appropriate engineering controls Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

Personal protective equipment

Eye/face protection Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Full contact Material: Nitrile rubber Minimum layer thickness: 0.11 mm Break through time: 480 min Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M) Splash contact Material: Nitrile rubber Minimum layer thickness: 0.11 mm Break through time: 480 min

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Sigma-Aldrich - 251275 Page 4 of 7

Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail [email protected], test method: EN374 If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industria situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario. Body Protection Impervious clothing, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection For nuisance exposures use type P95 (US) or type P1 (EU EN 143) particle r (US) or type ABEK-P2 (EU EN 143) respirator cartridges. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Control of environmental exposure Do not let product enter drains.

SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties

a) Appearance Form: crystalline Colour: white

b) Odour No data available

c) Odour Threshold No data available

d) pH 1.8 at ca.50 g/l at 25 °C

e) Melting point/freezing point

Melting point/range: 153 - 159 °C - lit.

f) Initial boiling point and boiling range

No data available

g) Flash point No data available

h) Evaporation rate No data available

i) Flammability (solid, gas) No data available

j) Upper/lower flammability or explosive limits

Lower explosion limit: 8 %(V)

k) Vapour pressure No data available

l) Vapour density No data available

m) Relative density No data available

n) Water solubility 383 g/l at 25 °C

o) Partition coefficient: n-octanol/water

log Pow: -1.639 at 20 °C

p) Auto-ignition temperature

No data available

q) Decomposition temperature

No data available

r) Viscosity No data available

s) Explosive properties No data available

t) Oxidizing properties No data available

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Sigma-Aldrich - 251275 Page 5 of 7

9.2 Other safety information No data available

SECTION 10: Stability and reactivity

10.1 Reactivity No data available

10.2 Chemical stability Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions No data available

10.4 Conditions to avoid No data available

10.5 Incompatible materials Oxidizing agents, Bases, Reducing agents, Nitrates

10.6 Hazardous decomposition products Other decomposition products - No data available Hazardous decomposition products formed under fire conditions. - Carbon oxides In the event of fire: see section 5

SECTION 11: Toxicological information

11.1 Information on toxicological effects

Acute toxicity LD50 Oral - Rat - 5,400 mg/kg(Citric acid) (OECD Test Guideline 401) LD50 Dermal - Rat - > 2,000 mg/kg(Citric acid) (OECD Test Guideline 402)

Skin corrosion/irritation Skin - Rabbit(Citric acid) Result: Mild skin irritation (OECD Test Guideline 404)

Serious eye damage/eye irritation Eyes - Rabbit(Citric acid) Result: Irritating to eyes. (OECD Test Guideline 405)

Respiratory or skin sensitisation Prolonged or repeated exposure may cause allergic reactions in certain sensitive individuals.(Citric acid)

Germ cell mutagenicity No data available(Citric acid)

Carcinogenicity

IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.

Reproductive toxicity

No data available(Citric acid)

Specific target organ toxicity - single exposure No data available(Citric acid)

Specific target organ toxicity - repeated exposure No data available

Aspiration hazard No data available(Citric acid)

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Sigma-Aldrich - 251275 Page 6 of 7

Additional Information RTECS: GE7350000 Vomiting, Diarrhoea, Damage to tooth enamel., Dermatitis, To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.(Citric acid)

SECTION 12: Ecological information

12.1 Toxicity Toxicity to fish mortality LC50 - Leuciscus idus melanotus - 440 mg/l - 48 h(Citric acid)

(OECD Test Guideline 203) Toxicity to daphnia and other aquatic invertebrates

static test - Daphnia magna (Water flea) - 1,535 mg/l - 24 h(Citric acid)

12.2 Persistence and degradability No data available

12.3 Bioaccumulative potential No data available

12.4 Mobility in soil No data available(Citric acid)

12.5 Results of PBT and vPvB assessment This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

12.6 Other adverse effects No data available

SECTION 13: Disposal considerations

13.1 Waste treatment methods

Product Offer surplus and non-recyclable solutions to a licensed disposal company. Dissolve or mix the material with a combustible solvent and burn in a chem scrubber.

Contaminated packaging Dispose of as unused product.

SECTION 14: Transport information

14.1 UN number ADR/RID: - IMDG: - IATA: -

14.2 UN proper shipping name ADR/RID: Not dangerous goods IMDG: Not dangerous goods IATA: Not dangerous goods

14.3 Transport hazard class(es) ADR/RID: - IMDG: - IATA: -

14.4 Packaging group ADR/RID: - IMDG: - IATA: -

14.5 Environmental hazards ADR/RID: no IMDG Marine pollutant: no IATA: no

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Sigma-Aldrich - 251275 Page 7 of 7

14.6 Special precautions for user No data available

SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

15.2 Chemical safety assessment For this product a chemical safety assessment was not carried out

SECTION 16: Other information

Full text of H-Statements referred to under sections 2 and 3.

H319 Causes serious eye irritation.

Further information Copyright 2016 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

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Aldrich - 792063 Page 1 of 7

SIGMA-ALDRICH sigma-aldrich.com SAFETY DATA SHEET

according to Regulation (EC) No. 1907/2006 Version 6.0 Revision Date 30.03.2016

Print Date 10.11.2016 GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifiers Product name : Copper(I) iodide

Product Number : 792063 Brand : Aldrich REACH No. : A registration number is not available for this substance as the substance

or its uses are exempted from registration, the annual tonnage does not require a registration or the registration is envisaged for a later registration deadline.

CAS-No. : 7681-65-4

1.2 Relevant identified uses of the substance or mixture and uses advised against

Identified uses : Laboratory chemicals, Manufacture of substances

1.3 Details of the supplier of the safety data sheet

Company : Sigma-Aldrich Chemical Pvt Limited Industrial Area, Anekal Taluka Plot No 12, 12 Bommasandra - Jigani Link Road 560100 BANGALORE INDIA

1.4 Emergency telephone number

Emergency Phone # : +91 98802 05043

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture

Classification according to Regulation (EC) No 1272/2008 Acute toxicity, Oral (Category 4), H302 Skin irritation (Category 2), H315 Serious eye damage (Category 1), H318 Skin sensitisation (Category 1), H317 Specific target organ toxicity - single exposure (Category 3), Respiratory system, H335 Acute aquatic toxicity (Category 1), H400 Chronic aquatic toxicity (Category 1), H410

For the full text of the H-Statements mentioned in this Section, see Section 16.

2.2 Label elements

Labelling according Regulation (EC) No 1272/2008 Pictogram

Signal word Danger Hazard statement(s) H302 Harmful if swallowed.

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H315 Causes skin irritation. H317 May cause an allergic skin reaction. H318 Causes serious eye damage. H335 May cause respiratory irritation. H410 Very toxic to aquatic life with long lasting effects. Precautionary statement(s) P280 Wear protective gloves/ eye protection/ face protection. P301 + P312 + P330 IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell.

Rinse mouth. P305 + P351 + P338 + P310 IF IN EYES: Rinse cautiously with water for several minutes. Remove

contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor.

Supplemental Hazard Statements

none

2.3 Other hazards This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

SECTION 3: Composition/information on ingredients

3.1 Substances Synonyms : Cuprous Iodide

Formula : CuI Molecular weight : 190.45 g/mol CAS-No. : 7681-65-4 EC-No. : 231-674-6 Hazardous ingredients according to Regulation (EC) No 1272/2008

Component Classification Concentration

Copper iodide

CAS-No. EC-No.

7681-65-4 231-674-6

Acute Tox. 4; Skin Irrit. 2; Eye Dam. 1; Skin Sens. 1; STOT SE 3; Aquatic Acute 1; Aquatic Chronic 1; H302, H315, H318, H317, H335, H400, H410

M-Factor - Aquatic Acute: 10

<= 100 %

For the full text of the H-Statements mentioned in this Section, see Section 16.

SECTION 4: First aid measures

4.1 Description of first aid measures

General advice Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact Wash off with soap and plenty of water. Consult a physician.

In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

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Aldrich - 792063 Page 3 of 7

4.2 Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

4.3 Indication of any immediate medical attention and special treatment needed No data available

SECTION 5: Firefighting measures

5.1 Extinguishing media

Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

5.2 Special hazards arising from the substance or mixture Hydrogen iodide, Copper oxides

5.3 Advice for firefighters Wear self-contained breathing apparatus for firefighting if necessary.

5.4 Further information No data available

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

6.3 Methods and materials for containment and cleaning up Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.

6.4 Reference to other sections For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

Light sensitive. Handle and store under inert gas. Hygroscopic. Storage class (TRGS 510): Non Combustible Solids

7.3 Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

8.1 Control parameters

8.2 Exposure controls

Appropriate engineering controls Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

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Personal protective equipment

Eye/face protection Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Body Protection Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use (EN 143) respirator cartridges as a backup to engineering controls. If th full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Control of environmental exposure Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties

a) Appearance Form: powder Colour: brown

b) Odour odourless

c) Odour Threshold No data available

d) pH No data available

e) Melting point/freezing point

605 °C

f) Initial boiling point and boiling range

1,290 °C

g) Flash point No data available

h) Evaporation rate No data available

i) Flammability (solid, gas) No data available

j) Upper/lower flammability or explosive limits

No data available

k) Vapour pressure 10 mmHg at 656 °C

l) Vapour density No data available

m) Relative density 5.620 g/cm3 at 20 °C

n) Water solubility insoluble

o) Partition coefficient: n-octanol/water

No data available

p) Auto-ignition temperature

No data available

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Aldrich - 792063 Page 5 of 7

q) Decomposition temperature

No data available

r) Viscosity No data available

s) Explosive properties No data available

t) Oxidizing properties No data available

9.2 Other safety information

Bulk density 1,400 kg/m3

SECTION 10: Stability and reactivity

10.1 Reactivity No data available

10.2 Chemical stability Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions No data available

10.4 Conditions to avoid No data available

10.5 Incompatible materials Oxidizing agents, Potassium, Alkali metals

10.6 Hazardous decomposition products Other decomposition products - No data available Hazardous decomposition products formed under fire conditions. - Hydrogen iodide, Copper oxides In the event of fire: see section 5

SECTION 11: Toxicological information

11.1 Information on toxicological effects

Acute toxicity LD50 Oral - Rat - female - 300 - 2,000 mg/kg(Copper iodide) (OECD Test Guideline 420) LD50 Dermal - Rat - male and female - > 2,000 mg/kg(Copper iodide) (OECD Test Guideline 402)

Skin corrosion/irritation No data available(Copper iodide)

Serious eye damage/eye irritation Eyes - Rabbit(Copper iodide) Result: Risk of serious damage to eyes. (OECD Test Guideline 405)

Respiratory or skin sensitisation Maximisation Test - Guinea pig(Copper iodide) Result: May cause sensitisation by skin contact. (OECD Test Guideline 406)

Germ cell mutagenicity No data available(Copper iodide)

Carcinogenicity

IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.

Reproductive toxicity No data available(Copper iodide)

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Specific target organ toxicity - single exposure No data available(Copper iodide)

Specific target organ toxicity - repeated exposure No data available

Aspiration hazard No data available(Copper iodide)

Additional Information RTECS: Not available Symptoms of systemic copper poisoning may include: capillary damage, heada central nervous system excitation followed by depression, jaundice, convu renal failure. Chronic copper poisoning is typified by hepatic cirrhosis, copper deposition in the cornea as exemplified by humans with Wilson's di lead to hemolytic anemia and accelerates arteriosclerosis., To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.(Copper iodide) Liver - Irregularities - Based on Human Evidence(Copper iodide)

SECTION 12: Ecological information

12.1 Toxicity No data available

12.2 Persistence and degradability No data available

12.3 Bioaccumulative potential No data available

12.4 Mobility in soil No data available(Copper iodide)

12.5 Results of PBT and vPvB assessment This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

12.6 Other adverse effects Very toxic to aquatic life with long lasting effects.

SECTION 13: Disposal considerations

13.1 Waste treatment methods

Product Offer surplus and non-recyclable solutions to a licensed disposal company. Dissolve or mix the material with a combustible solvent and burn in a chem scrubber.

Contaminated packaging Dispose of as unused product.

SECTION 14: Transport information

14.1 UN number ADR/RID: 3077 IMDG: 3077 IATA: 3077

14.2 UN proper shipping name ADR/RID: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (Copper iodide) IMDG: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (Copper iodide) IATA: Environmentally hazardous substance, solid, n.o.s. (Copper iodide)

14.3 Transport hazard class(es) ADR/RID: 9 IMDG: 9 IATA: 9

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14.4 Packaging group ADR/RID: III IMDG: III IATA: III

14.5 Environmental hazards ADR/RID: yes IMDG Marine pollutant: no IATA: yes

14.6 Special precautions for user

Further information EHS-Mark required (ADR 2.2.9.1.10, IMDG code 2.10.3) for single packagings and combination packagings containing inner packagings with Dangerous Goods > 5L for liquids or > 5kg for solids.

SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

15.2 Chemical safety assessment For this product a chemical safety assessment was not carried out

SECTION 16: Other information

Full text of H-Statements referred to under sections 2 and 3.

H302 Harmful if swallowed. H315 Causes skin irritation. H317 May cause an allergic skin reaction. H318 Causes serious eye damage. H335 May cause respiratory irritation. H400 Very toxic to aquatic life. H410 Very toxic to aquatic life with long lasting effects.

Further information Copyright 2016 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

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Sigma-Aldrich - 227048 Page 1 of 8

SIGMA-ALDRICH sigma-aldrich.com SAFETY DATA SHEET

according to Regulation (EC) No. 1907/2006 Version 6.0 Revision Date 31.03.2016

Print Date 10.11.2016 GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifiers Product name : Cyclohexane

Product Number : 227048 Brand : Sigma-Aldrich Index-No. : 601-017-00-1 REACH No. : 01-2119463273-41-XXXX

CAS-No. : 110-82-7

1.2 Relevant identified uses of the substance or mixture and uses advised against

Identified uses : Laboratory chemicals, Manufacture of substances

1.3 Details of the supplier of the safety data sheet

Company : Sigma-Aldrich Chemical Pvt Limited Industrial Area, Anekal Taluka Plot No 12, 12 Bommasandra - Jigani Link Road 560100 BANGALORE INDIA

1.4 Emergency telephone number

Emergency Phone # : +91 98802 05043

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture

Classification according to Regulation (EC) No 1272/2008 Flammable liquids (Category 2), H225 Skin irritation (Category 2), H315 Specific target organ toxicity - single exposure (Category 3), Central nervous system, H336 Aspiration hazard (Category 1), H304 Acute aquatic toxicity (Category 1), H400 Chronic aquatic toxicity (Category 1), H410

For the full text of the H-Statements mentioned in this Section, see Section 16.

2.2 Label elements

Labelling according Regulation (EC) No 1272/2008 Pictogram

Signal word Danger Hazard statement(s) H225 Highly flammable liquid and vapour. H304 May be fatal if swallowed and enters airways. H315 Causes skin irritation. H336 May cause drowsiness or dizziness.

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H410 Very toxic to aquatic life with long lasting effects. Precautionary statement(s) P210 Keep away from heat, hot surfaces, sparks, open flames and other

ignition sources. No smoking. P261 Avoid breathing vapours. P273 Avoid release to the environment. P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor. P331 Do NOT induce vomiting. P501 Dispose of contents/ container to an approved waste disposal plant. Supplemental Hazard Statements

none

2.3 Other hazards This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

SECTION 3: Composition/information on ingredients

3.1 Substances Formula : C<SB>6</>H<SB>12</> Molecular weight : 84.16 g/mol CAS-No. : 110-82-7 EC-No. : 203-806-2 Index-No. : 601-017-00-1 Registration number : 01-2119463273-41-XXXX

Hazardous ingredients according to Regulation (EC) No 1272/2008

Component Classification Concentration

Cyclohexane

CAS-No. EC-No. Index-No.

110-82-7 203-806-2 601-017-00-1

Flam. Liq. 2; Skin Irrit. 2; STOT SE 3; Asp. Tox. 1; Aquatic Acute 1; Aquatic Chronic 1; H225, H315, H336, H304, H400, H410

M-Factor - Aquatic Acute: 1

<= 100 %

For the full text of the H-Statements mentioned in this Section, see Section 16.

SECTION 4: First aid measures

4.1 Description of first aid measures

General advice Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact Wash off with soap and plenty of water. Consult a physician.

In case of eye contact Flush eyes with water as a precaution.

If swallowed Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

4.2 Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

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4.3 Indication of any immediate medical attention and special treatment needed No data available

SECTION 5: Firefighting measures

5.1 Extinguishing media

Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

5.2 Special hazards arising from the substance or mixture Carbon oxides

5.3 Advice for firefighters Wear self-contained breathing apparatus for firefighting if necessary.

5.4 Further information Use water spray to cool unopened containers.

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures Use personal protective equipment. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to form explosive concentrations. Vapours can accumulate in low areas. For personal protection see section 8.

6.2 Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

6.3 Methods and materials for containment and cleaning up Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations (see section 13).

6.4 Reference to other sections For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling Avoid contact with skin and eyes. Avoid inhalation of vapour or mist. Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic charge. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

Store under inert gas. Storage class (TRGS 510): Flammable liquids

7.3 Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

8.1 Control parameters

8.2 Exposure controls

Appropriate engineering controls Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

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Personal protective equipment

Eye/face protection Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Full contact Material: Nitrile rubber Minimum layer thickness: 0.4 mm Break through time: 480 min Material tested:Camatril® (KCL 730 / Aldrich Z677442, Size M) Splash contact Material: Nitrile rubber Minimum layer thickness: 0.11 mm Break through time: 35 min Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail [email protected], test method: EN374 If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industria situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario. Body Protection Complete suit protecting against chemicals, Flame retardant antistatic protective clothing., The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use (US) or type ABEK (EN 14387) respirator cartridges as a backup to enginee protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Control of environmental exposure Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties

a) Appearance Form: liquid Colour: colourless

b) Odour No data available

c) Odour Threshold No data available

d) pH No data available

e) Melting point/freezing point

Melting point/range: 4 - 7 °C - lit.

f) Initial boiling point and boiling range

80.7 °C - lit.

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g) Flash point -17.99 °C - closed cup

h) Evaporation rate No data available

i) Flammability (solid, gas) No data available

j) Upper/lower flammability or explosive limits

Upper explosion limit: 9 %(V) Lower explosion limit: 1 %(V)

k) Vapour pressure 168.8 mmHg at 37.7 °C 77.0 mmHg at 20.0 °C

l) Vapour density No data available

m) Relative density 0.779 g/cm3 at 25 °C

n) Water solubility No data available

o) Partition coefficient: n-octanol/water

log Pow: 3.44

p) Auto-ignition temperature

260.0 °C

q) Decomposition temperature

No data available

r) Viscosity No data available

s) Explosive properties No data available

t) Oxidizing properties No data available

9.2 Other safety information No data available

SECTION 10: Stability and reactivity

10.1 Reactivity No data available

10.2 Chemical stability Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions No data available

10.4 Conditions to avoid Heat, flames and sparks.

10.5 Incompatible materials Strong oxidizing agents

10.6 Hazardous decomposition products Hazardous decomposition products formed under fire conditions. - Carbon oxides Other decomposition products - No data available In the event of fire: see section 5

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Sigma-Aldrich - 227048 Page 6 of 8

SECTION 11: Toxicological information

11.1 Information on toxicological effects

Acute toxicity LD50 Oral - Rat - 12,705 mg/kg(Cyclohexane) LC50 Inhalation - Rat - 4 h - 34,000 mg/l(Cyclohexane) (OECD Test Guideline 403) LD50 Dermal - Rabbit - > 2,000 mg/kg(Cyclohexane)

Skin corrosion/irritation Skin - Rabbit(Cyclohexane) Result: No skin irritation Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)(Cyclohexane)

Serious eye damage/eye irritation Eyes - Rabbit(Cyclohexane) Result: Mild eye irritation

Respiratory or skin sensitisation No data available(Cyclohexane)

Germ cell mutagenicity No data available(Cyclohexane)

Carcinogenicity

IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.

Reproductive toxicity No data available(Cyclohexane)

Specific target organ toxicity - single exposure No data available(Cyclohexane)

Specific target organ toxicity - repeated exposure No data available

Aspiration hazard May be fatal if swallowed and enters airways.(Cyclohexane)

Additional Information RTECS: GU6300000 Central nervous system depression, Drowsiness, Irritability, Dizziness, Gastrointestinal disturbance, Lung irritation, chest pain, pulmonary edema(Cyclohexane)

SECTION 12: Ecological information

12.1 Toxicity Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2) Toxicity to daphnia and other aquatic invertebrates

Immobilization EC50 - Daphnia magna (Water flea) - 0.9 mg/l - 48 h(Cyclohexane) (OECD Test Guideline 202)

Toxicity to algae EC50 - Pseudokirchneriella subcapitata (green algae) - 3.4 mg/l - 72

h(Cyclohexane) (OECD Test Guideline 201)

12.2 Persistence and degradability Biodegradability Result: - Readily biodegradable

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12.3 Bioaccumulative potential No data available

12.4 Mobility in soil No data available(Cyclohexane)

12.5 Results of PBT and vPvB assessment This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

12.6 Other adverse effects Very toxic to aquatic life.

SECTION 13: Disposal considerations

13.1 Waste treatment methods

Product Burn in a chemical incinerator equipped with an afterburner and scrubber b highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company.

Contaminated packaging Dispose of as unused product.

SECTION 14: Transport information

14.1 UN number ADR/RID: 1145 IMDG: 1145 IATA: 1145

14.2 UN proper shipping name ADR/RID: CYCLOHEXANE IMDG: CYCLOHEXANE IATA: Cyclohexane

14.3 Transport hazard class(es) ADR/RID: 3 IMDG: 3 IATA: 3

14.4 Packaging group ADR/RID: II IMDG: II IATA: II

14.5 Environmental hazards ADR/RID: no IMDG Marine pollutant: no IATA: no

14.6 Special precautions for user No data available

SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

15.2 Chemical safety assessment For this product a chemical safety assessment was not carried out

SECTION 16: Other information

Full text of H-Statements referred to under sections 2 and 3.

H225 Highly flammable liquid and vapour. H304 May be fatal if swallowed and enters airways. H315 Causes skin irritation. H336 May cause drowsiness or dizziness. H400 Very toxic to aquatic life. H410 Very toxic to aquatic life with long lasting effects.

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Sigma-Aldrich - 227048 Page 8 of 8

Further information Copyright 2016 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

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Aldrich - 142549 Page 1 of 7

SIGMA-ALDRICH sigma-aldrich.com SAFETY DATA SHEET

according to Regulation (EC) No. 1907/2006 Version 6.0 Revision Date 30.03.2016

Print Date 10.11.2016 GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifiers Product name : 3-Chloropropylamine hydrochloride

Product Number : 142549 Brand : Aldrich REACH No. : A registration number is not available for this substance as the substance

or its uses are exempted from registration, the annual tonnage does not require a registration or the registration is envisaged for a later registration deadline.

CAS-No. : 6276-54-6

1.2 Relevant identified uses of the substance or mixture and uses advised against

Identified uses : Laboratory chemicals, Manufacture of substances

1.3 Details of the supplier of the safety data sheet

Company : Sigma-Aldrich Chemical Pvt Limited Industrial Area, Anekal Taluka Plot No 12, 12 Bommasandra - Jigani Link Road 560100 BANGALORE INDIA

1.4 Emergency telephone number

Emergency Phone # : +91 98802 05043

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture

Classification according to Regulation (EC) No 1272/2008 Skin irritation (Category 2), H315 Eye irritation (Category 2), H319 Specific target organ toxicity - single exposure (Category 3), Respiratory system, H335

For the full text of the H-Statements mentioned in this Section, see Section 16.

2.2 Label elements

Labelling according Regulation (EC) No 1272/2008 Pictogram

Signal word Warning Hazard statement(s) H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation.

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Precautionary statement(s) P261 Avoid breathing dust. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove

contact lenses, if present and easy to do. Continue rinsing. Supplemental Hazard Statements

none

2.3 Other hazards This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

SECTION 3: Composition/information on ingredients

3.1 Substances Synonyms : 1-Amino-3-chloropropanehydrochloride

Formula : C3H8ClN · HCl

Molecular weight : 130.02 g/mol CAS-No. : 6276-54-6 EC-No. : 228-474-6 Hazardous ingredients according to Regulation (EC) No 1272/2008

Component Classification Concentration

3-Chloropropylamine hydrochloride

CAS-No. EC-No.

6276-54-6 228-474-6

Skin Irrit. 2; Eye Irrit. 2; STOT SE 3; H315, H319, H335

<= 100 %

For the full text of the H-Statements mentioned in this Section, see Section 16.

SECTION 4: First aid measures

4.1 Description of first aid measures

General advice Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact Wash off with soap and plenty of water. Consult a physician.

In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

4.2 Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

4.3 Indication of any immediate medical attention and special treatment needed No data available

SECTION 5: Firefighting measures

5.1 Extinguishing media

Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

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5.2 Special hazards arising from the substance or mixture Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

5.3 Advice for firefighters Wear self-contained breathing apparatus for firefighting if necessary.

5.4 Further information No data available

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions Do not let product enter drains.

6.3 Methods and materials for containment and cleaning up Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.

6.4 Reference to other sections For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Non Combustible Solids

7.3 Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

8.1 Control parameters

8.2 Exposure controls

Appropriate engineering controls Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

Personal protective equipment

Eye/face protection Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Full contact Material: Nitrile rubber Minimum layer thickness: 0.11 mm

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Break through time: 480 min Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M) Splash contact Material: Nitrile rubber Minimum layer thickness: 0.11 mm Break through time: 480 min Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail [email protected], test method: EN374 If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industria situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario. Body Protection Impervious clothing, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection For nuisance exposures use type P95 (US) or type P1 (EU EN 143) particle r (US) or type ABEK-P2 (EU EN 143) respirator cartridges. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Control of environmental exposure Do not let product enter drains.

SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties

a) Appearance Form: powder Colour: light brown

b) Odour No data available

c) Odour Threshold No data available

d) pH No data available

e) Melting point/freezing point

Melting point/range: 145 - 150 °C - lit.

f) Initial boiling point and boiling range

No data available

g) Flash point No data available

h) Evaporation rate No data available

i) Flammability (solid, gas) No data available

j) Upper/lower flammability or explosive limits

No data available

k) Vapour pressure No data available

l) Vapour density No data available

m) Relative density No data available

n) Water solubility No data available

o) Partition coefficient: n-octanol/water

No data available

p) Auto-ignition temperature

No data available

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q) Decomposition temperature

No data available

r) Viscosity No data available

s) Explosive properties No data available

t) Oxidizing properties No data available

9.2 Other safety information No data available

SECTION 10: Stability and reactivity

10.1 Reactivity No data available

10.2 Chemical stability Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions No data available

10.4 Conditions to avoid No data available

10.5 Incompatible materials Strong oxidizing agents

10.6 Hazardous decomposition products Hazardous decomposition products formed under fire conditions. - Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas Other decomposition products - No data available In the event of fire: see section 5

SECTION 11: Toxicological information

11.1 Information on toxicological effects

Acute toxicity No data available3-Chloropropylamine hydrochloride

Skin corrosion/irritation No data available(3-Chloropropylamine hydrochloride)

Serious eye damage/eye irritation No data available(3-Chloropropylamine hydrochloride)

Respiratory or skin sensitisation No data available(3-Chloropropylamine hydrochloride)

Germ cell mutagenicity No data available(3-Chloropropylamine hydrochloride)

Carcinogenicity

IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.

Reproductive toxicity No data available(3-Chloropropylamine hydrochloride)

Specific target organ toxicity - single exposure Inhalation - May cause respiratory irritation.(3-Chloropropylamine hydrochloride)

Specific target organ toxicity - repeated exposure No data available

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Aspiration hazard No data available(3-Chloropropylamine hydrochloride)

Additional Information RTECS: Not available To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.(3-Chloropropylamine hydrochloride)

SECTION 12: Ecological information

12.1 Toxicity No data available

12.2 Persistence and degradability No data available

12.3 Bioaccumulative potential No data available

12.4 Mobility in soil No data available(3-Chloropropylamine hydrochloride)

12.5 Results of PBT and vPvB assessment This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

12.6 Other adverse effects No data available

SECTION 13: Disposal considerations

13.1 Waste treatment methods

Product Offer surplus and non-recyclable solutions to a licensed disposal company. Dissolve or mix the material with a combustible solvent and burn in a chem scrubber.

Contaminated packaging Dispose of as unused product.

SECTION 14: Transport information

14.1 UN number ADR/RID: - IMDG: - IATA: -

14.2 UN proper shipping name ADR/RID: Not dangerous goods IMDG: Not dangerous goods IATA: Not dangerous goods

14.3 Transport hazard class(es) ADR/RID: - IMDG: - IATA: -

14.4 Packaging group ADR/RID: - IMDG: - IATA: -

14.5 Environmental hazards ADR/RID: no IMDG Marine pollutant: no IATA: no

14.6 Special precautions for user No data available

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SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

15.2 Chemical safety assessment For this product a chemical safety assessment was not carried out

SECTION 16: Other information

Full text of H-Statements referred to under sections 2 and 3.

H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation.

Further information Copyright 2016 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

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SIGMA-ALDRICH sigma-aldrich.com SAFETY DATA SHEET

according to Regulation (EC) No. 1907/2006 Version 6.0 Revision Date 31.03.2016

Print Date 10.11.2016 GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifiers Product name : Diethyl carbonate

Product Number : 517135 Brand : Aldrich REACH No. : A registration number is not available for this substance as the substance

or its uses are exempted from registration, the annual tonnage does not require a registration or the registration is envisaged for a later registration deadline.

CAS-No. : 105-58-8

1.2 Relevant identified uses of the substance or mixture and uses advised against

Identified uses : Laboratory chemicals, Manufacture of substances

1.3 Details of the supplier of the safety data sheet

Company : Sigma-Aldrich Chemical Pvt Limited Industrial Area, Anekal Taluka Plot No 12, 12 Bommasandra - Jigani Link Road 560100 BANGALORE INDIA

1.4 Emergency telephone number

Emergency Phone # : +91 98802 05043

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture

Classification according to Regulation (EC) No 1272/2008 Flammable liquids (Category 3), H226 Skin irritation (Category 2), H315 Eye irritation (Category 2), H319 Specific target organ toxicity - single exposure (Category 3), H335

For the full text of the H-Statements mentioned in this Section, see Section 16.

2.2 Label elements

Labelling according Regulation (EC) No 1272/2008 Pictogram

Signal word Warning Hazard statement(s) H226 Flammable liquid and vapour. H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation.

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Precautionary statement(s) P261 Avoid breathing vapours. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove

contact lenses, if present and easy to do. Continue rinsing. Supplemental Hazard Statements

none

2.3 Other hazards This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

SECTION 3: Composition/information on ingredients

3.1 Substances Formula : C<SB>5</>H<SB>10</>O<SB>3</>C<SB>5</>H<SB>10</>O<SB>3</> Molecular weight : 118.13 g/mol CAS-No. : 105-58-8 EC-No. : 203-311-1 Hazardous ingredients according to Regulation (EC) No 1272/2008

Component Classification Concentration

Diethyl carbonate

CAS-No. EC-No.

105-58-8 203-311-1

Flam. Liq. 3; H226 <= 100 %

For the full text of the H-Statements mentioned in this Section, see Section 16.

SECTION 4: First aid measures

4.1 Description of first aid measures

General advice Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact Wash off with soap and plenty of water. Consult a physician.

In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

4.2 Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

4.3 Indication of any immediate medical attention and special treatment needed No data available

SECTION 5: Firefighting measures

5.1 Extinguishing media

Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

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5.2 Special hazards arising from the substance or mixture Carbon oxides

5.3 Advice for firefighters Wear self-contained breathing apparatus for firefighting if necessary.

5.4 Further information Use water spray to cool unopened containers.

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures Use personal protective equipment. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to form explosive concentrations. Vapours can accumulate in low areas. For personal protection see section 8.

6.2 Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

6.3 Methods and materials for containment and cleaning up Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations (see section 13).

6.4 Reference to other sections For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling Avoid contact with skin and eyes. Avoid inhalation of vapour or mist. Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic charge. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

Store under inert gas. Moisture sensitive. Storage class (TRGS 510): Flammable Liquids

7.3 Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

8.1 Control parameters

8.2 Exposure controls

Appropriate engineering controls Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

Personal protective equipment

Eye/face protection Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.

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The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Splash contact Material: butyl-rubber Minimum layer thickness: 0.3 mm Break through time: 120 min Material tested:Butoject® (KCL 897 / Aldrich Z677647, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail [email protected], test method: EN374 If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industria situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario. Body Protection Impervious clothing, Flame retardant antistatic protective clothing., The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use (US) or type ABEK (EN 14387) respirator cartridges as a backup to enginee protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Control of environmental exposure Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties

a) Appearance Form: clear, liquid Colour: colourless

b) Odour No data available

c) Odour Threshold No data available

d) pH No data available

e) Melting point/freezing point

Melting point/range: -43 °C - lit.

f) Initial boiling point and boiling range

126 - 128 °C - lit.

g) Flash point 25 °C - closed cup

h) Evaporation rate No data available

i) Flammability (solid, gas) No data available

j) Upper/lower flammability or explosive limits

No data available

k) Vapour pressure 59 mmHg at 37.8 °C 10 mmHg at 23.8 °C

l) Vapour density 4.08 - (Air = 1.0)

m) Relative density 0.975 g/cm3 at 25 °C

n) Water solubility insoluble

o) Partition coefficient: n-octanol/water

No data available

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p) Auto-ignition temperature

No data available

q) Decomposition temperature

No data available

r) Viscosity No data available

s) Explosive properties No data available

t) Oxidizing properties No data available

9.2 Other safety information

Relative vapour density 4.08 - (Air = 1.0)

SECTION 10: Stability and reactivity

10.1 Reactivity No data available

10.2 Chemical stability Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions No data available

10.4 Conditions to avoid Heat, flames and sparks.

10.5 Incompatible materials Strong acids, Oxidizing agents, Strong bases, Reducing agents

10.6 Hazardous decomposition products Hazardous decomposition products formed under fire conditions. - Carbon oxides Other decomposition products - No data available In the event of fire: see section 5

SECTION 11: Toxicological information

11.1 Information on toxicological effects

Acute toxicity LD50 Oral - Rat - male - > 4,876 mg/kg(Diethyl carbonate) LC50 Inhalation - Rat - female - 7 h - > 1.268 mg/l(Diethyl carbonate) LD50 Subcutaneous - Rat - 8,500 mg/kg(Diethyl carbonate)

Skin corrosion/irritation Skin - Rabbit(Diethyl carbonate) Result: No skin irritation

Serious eye damage/eye irritation Eyes - Rabbit(Diethyl carbonate) Result: No eye irritation

Respiratory or skin sensitisation - Mouse(Diethyl carbonate) Result: Does not cause skin sensitisation. (OECD Test Guideline 429)

Germ cell mutagenicity No data available(Diethyl carbonate) Salmonella typhimurium Result: negative

Carcinogenicity

IARC: No component of this product present at levels greater than or equal to 0.1% is identified as

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probable, possible or confirmed human carcinogen by IARC.

Reproductive toxicity

Specific target organ toxicity - single exposure No data available(Diethyl carbonate)

Specific target organ toxicity - repeated exposure No data available

Aspiration hazard No data available(Diethyl carbonate)

Additional Information

Repeated dose toxicity - Mouse - male - Oral - Lowest observed adverse effect level - 50 mg/kg(Diethyl carbonate) RTECS: FF9800000 To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.(Diethyl carbonate)

SECTION 12: Ecological information

12.1 Toxicity No data available Toxicity to daphnia and other aquatic invertebrates

Immobilization NOEC - Daphnia magna Straus - >= 100 mg/l - 48 h(Diethyl carbonate) (OECD Test Guideline 202)

Toxicity to algae Growth inhibition NOEC - Desmodesmus subspicatus (green algae) - >= 100

mg/l - 72 h(Diethyl carbonate) (OECD Test Guideline 201)

12.2 Persistence and degradability Biodegradability Result: 75 % - Readily biodegradable

12.3 Bioaccumulative potential No data available

12.4 Mobility in soil No data available(Diethyl carbonate)

12.5 Results of PBT and vPvB assessment This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

12.6 Other adverse effects No data available

SECTION 13: Disposal considerations

13.1 Waste treatment methods

Product Burn in a chemical incinerator equipped with an afterburner and scrubber b highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company.

Contaminated packaging Dispose of as unused product.

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SECTION 14: Transport information

14.1 UN number ADR/RID: 2366 IMDG: 2366 IATA: 2366

14.2 UN proper shipping name ADR/RID: DIETHYL CARBONATE IMDG: DIETHYL CARBONATE IATA: Diethyl carbonate

14.3 Transport hazard class(es) ADR/RID: 3 IMDG: 3 IATA: 3

14.4 Packaging group ADR/RID: III IMDG: III IATA: III

14.5 Environmental hazards ADR/RID: no IMDG Marine pollutant: no IATA: no

14.6 Special precautions for user No data available

SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

15.2 Chemical safety assessment For this product a chemical safety assessment was not carried out

SECTION 16: Other information

Full text of H-Statements referred to under sections 2 and 3.

H226 Flammable liquid and vapour. H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation.

Further information Copyright 2016 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

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Sigma-Aldrich - 270997 Page 1 of 8

SIGMA-ALDRICH sigma-aldrich.com SAFETY DATA SHEET

according to Regulation (EC) No. 1907/2006 Version 6.1 Revision Date 15.07.2016

Print Date 10.11.2016 GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifiers Product name : Dichloromethane

Product Number : 270997 Brand : Sigma-Aldrich Index-No. : 602-004-00-3 REACH No. : 01-2119480404-41-XXXX

CAS-No. : 75-09-2

1.2 Relevant identified uses of the substance or mixture and uses advised against

Identified uses : Laboratory chemicals, Manufacture of substances

1.3 Details of the supplier of the safety data sheet

Company : Sigma-Aldrich Chemical Pvt Limited Industrial Area, Anekal Taluka Plot No 12, 12 Bommasandra - Jigani Link Road 560100 BANGALORE INDIA

1.4 Emergency telephone number

Emergency Phone # : +91 98802 05043

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture

Classification according to Regulation (EC) No 1272/2008 Skin irritation (Category 2), H315 Eye irritation (Category 2), H319 Carcinogenicity (Category 2), H351 Specific target organ toxicity - single exposure (Category 3), Central nervous system, H336 Specific target organ toxicity - single exposure (Category 3), Respiratory system, H335 Specific target organ toxicity - repeated exposure, Oral (Category 2), Liver, Blood, H373 Specific target organ toxicity - repeated exposure, Inhalation (Category 2), Central nervous system, H373

For the full text of the H-Statements mentioned in this Section, see Section 16.

2.2 Label elements

Labelling according Regulation (EC) No 1272/2008 Pictogram

Signal word Warning Hazard statement(s) H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation.

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H336 May cause drowsiness or dizziness. H351 Suspected of causing cancer. H373 May cause damage to organs (Liver, Blood) through prolonged or

repeated exposure if swallowed. H373 May cause damage to organs (Central nervous system) through

prolonged or repeated exposure if inhaled. Precautionary statement(s) P260 Do not breathe dust/ fume/ gas/ mist/ vapours/ spray. P280 Wear protective gloves/ protective clothing/ eye protection/ face

protection. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove

contact lenses, if present and easy to do. Continue rinsing. Supplemental Hazard Statements

none

2.3 Other hazards This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

SECTION 3: Composition/information on ingredients

3.1 Substances Synonyms : Methylene chloride

DCM

Formula : CH2Cl2

Molecular weight : 84.93 g/mol CAS-No. : 75-09-2 EC-No. : 200-838-9 Index-No. : 602-004-00-3 Registration number : 01-2119480404-41-XXXX

Hazardous ingredients according to Regulation (EC) No 1272/2008

Component Classification Concentration

Methylene chloride

CAS-No. EC-No. Index-No.

75-09-2 200-838-9 602-004-00-3

Skin Irrit. 2; Eye Irrit. 2; Carc. 2; STOT SE 3; STOT RE 2; H315, H319, H351, H336, H335, H373, H373

<= 100 %

For the full text of the H-Statements mentioned in this Section, see Section 16.

SECTION 4: First aid measures

4.1 Description of first aid measures

General advice Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact Wash off with soap and plenty of water. Consult a physician.

In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

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4.2 Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

4.3 Indication of any immediate medical attention and special treatment needed No data available

SECTION 5: Firefighting measures

5.1 Extinguishing media

Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

5.2 Special hazards arising from the substance or mixture Carbon oxides, Hydrogen chloride gas

5.3 Advice for firefighters Wear self-contained breathing apparatus for firefighting if necessary.

5.4 Further information No data available

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures Use personal protective equipment. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. For personal protection see section 8.

6.2 Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

6.3 Methods and materials for containment and cleaning up Soak up with inert absorbent material and dispose of as hazardous waste. Keep in suitable, closed containers for disposal.

6.4 Reference to other sections For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling Avoid contact with skin and eyes. Avoid inhalation of vapour or mist. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

Heat sensitive. Handle and store under inert gas. Storage class (TRGS 510): Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

7.3 Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

8.1 Control parameters

Derived No Effect Level (DNEL)

Application Area Exposure routes

Health effect Value

Workers Inhalation Acute systemic effects 706 mg/m3

Workers Inhalation Long-term systemic effects 353 mg/m3

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Workers Skin contact Long-term systemic effects 4750mg/kg BW/d

Consumers Ingestion Long-term systemic effects 0.06mg/kg BW/d

Consumers Inhalation Long-term systemic effects 88.3 mg/m3

Consumers Skin contact Long-term systemic effects 2395mg/kg BW/d

Consumers Inhalation Acute systemic effects 353 mg/m3

Predicted No Effect Concentration (PNEC)

Compartment Value

Soil 0.583 mg/kg

Marine water 0.194 mg/l

Fresh water 0.54 mg/l

Marine sediment 1.61 mg/kg

Fresh water sediment 4.47 mg/kg

Onsite sewage treatment plant 26 mg/l

Aquatic intermittent release 0.27 mg/l

8.2 Exposure controls

Appropriate engineering controls Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

Personal protective equipment

Eye/face protection Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Splash contact Material: Fluorinated rubber Minimum layer thickness: 0.7 mm Break through time: 148 min Material tested:Vitoject® (KCL 890 / Aldrich Z677698, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail [email protected], test method: EN374 If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industria situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario. Body Protection Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use (US) or type AXBEK (EN 14387) respirator cartridges as a backup to engine protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Control of environmental exposure Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

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SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties

a) Appearance Form: liquid Colour: colourless

b) Odour No data available

c) Odour Threshold No data available

d) pH No data available

e) Melting point/freezing point

Melting point/range: -97 °C

f) Initial boiling point and boiling range

39.8 - 40 °C

g) Flash point No data available

h) Evaporation rate 0.71

i) Flammability (solid, gas) No data available

j) Upper/lower flammability or explosive limits

Upper explosion limit: 19 %(V) Lower explosion limit: 12 %(V)

k) Vapour pressure 470.9 hPa at 20.0 °C

l) Vapour density 2.93 - (Air = 1.0)

m) Relative density 1.325 g/mL at 25 °C

n) Water solubility slightly soluble

o) Partition coefficient: n-octanol/water

log Pow: 1.25

p) Auto-ignition temperature

556.1 °C 662.0 °C

q) Decomposition temperature

No data available

r) Viscosity No data available

s) Explosive properties No data available

t) Oxidizing properties No data available

9.2 Other safety information

Relative vapour density 2.93 - (Air = 1.0)

SECTION 10: Stability and reactivity

10.1 Reactivity No data available

10.2 Chemical stability Stable under recommended storage conditions. Contains the following stabiliser(s): (>0.005 - <0.015 %)

10.3 Possibility of hazardous reactions No data available

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10.4 Conditions to avoid Heat, flames and sparks. Exposure to sunlight.

10.5 Incompatible materials Alkali metals, Aluminum, Strong oxidizing agents, Bases, Amines, Magnesium, Strong acids and strong bases, Vinyl compounds

10.6 Hazardous decomposition products Other decomposition products - No data available Hazardous decomposition products formed under fire conditions. - Carbon oxides, Hydrogen chloride gas In the event of fire: see section 5

SECTION 11: Toxicological information

11.1 Information on toxicological effects

Acute toxicity LD50 Oral - Rat - > 2,000 mg/kg(Methylene chloride) LC50 Inhalation - Rat - 52,000 mg/m3(Methylene chloride) LD50 Dermal - Rat - > 2,000 mg/kg(Methylene chloride) (OECD Test Guideline 402)

Skin corrosion/irritation Skin - Rabbit(Methylene chloride) Result: Irritating to skin. - 24 h (Draize Test)

Serious eye damage/eye irritation Eyes - Rabbit(Methylene chloride) Result: Irritating to eyes. - 24 h (Draize Test)

Respiratory or skin sensitisation No data available(Methylene chloride)

Germ cell mutagenicity (Methylene chloride) Rat DNA damage

Carcinogenicity Limited evidence of carcinogenicity in animal studies(Methylene chloride) Suspected human carcinogens(Methylene chloride)

IARC: 2A - Group 2A: Probably carcinogenic to humans (Methylene chloride)

Reproductive toxicity

No data available(Methylene chloride)

Specific target organ toxicity - single exposure May cause respiratory irritation.(Methylene chloride) May cause drowsiness or dizziness.(Methylene chloride)

Specific target organ toxicity - repeated exposure Inhalation - May cause damage to organs through prolonged or repeated exposure. - Central nervous system Oral - May cause damage to organs through prolonged or repeated exposure. - Liver, Blood

Aspiration hazard No data available(Methylene chloride)

Additional Information RTECS: PA8050000

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Dichloromethane is metabolized in the body producing carbon monoxide which blood, reducing the oxygen-carrying capacity of the blood., Acts as a simple asphyxiant by displacing air., anesthetic effects, Difficulty in breathing, Headache, Dizziness, Prolonged or repeated contact with skin may cause:, defatting, Dermatitis, Contact with eyes can cause:, Redness, Blurred vision, Provokes tears., Effects due to ingestion may include:, Gastrointestinal discomfort, Central nervous system depression, Paresthesia., Drowsiness, Convulsions, Conjunctivitis., Pulmonary edema. Effects may be delayed., Irregular breathing., Stomach/intestinal disorders, Nausea, Vomiting, Increased liver enzymes., Weakness, Heavy or prolonged skin exposure may result in the absorption of harmful amounts of material., Abdominal pain(Methylene chloride) To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.(Methylene chloride)

SECTION 12: Ecological information

12.1 Toxicity Toxicity to fish LC50 - Pimephales promelas (fathead minnow) - 193.00 mg/l - 96 h(Methylene

chloride) NOEC - Cyprinodon variegatus (sheepshead minnow) - 130 mg/l - 96

h(Methylene chloride) Toxicity to daphnia and other aquatic invertebrates

EC50 - Daphnia magna (Water flea) - 1,682.00 mg/l - 48 h(Methylene chloride)

12.2 Persistence and degradability Biodegradability Result: < 26 % - Not readily biodegradable.

(OECD Test Guideline 301C)

12.3 Bioaccumulative potential Does not bioaccumulate.

12.4 Mobility in soil No data available(Methylene chloride)

12.5 Results of PBT and vPvB assessment This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

12.6 Other adverse effects

SECTION 13: Disposal considerations

13.1 Waste treatment methods

Product Offer surplus and non-recyclable solutions to a licensed disposal company.

Contaminated packaging Dispose of as unused product.

SECTION 14: Transport information

14.1 UN number ADR/RID: 1593 IMDG: 1593 IATA: 1593

14.2 UN proper shipping name ADR/RID: DICHLOROMETHANE IMDG: DICHLOROMETHANE IATA: Dichloromethane

14.3 Transport hazard class(es) ADR/RID: 6.1 IMDG: 6.1 IATA: 6.1

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14.4 Packaging group ADR/RID: III IMDG: III IATA: III

14.5 Environmental hazards ADR/RID: no IMDG Marine pollutant: no IATA: no

14.6 Special precautions for user No data available

SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

15.2 Chemical safety assessment A Chemical Safety Assessment has been carried out for this substance.

SECTION 16: Other information

Full text of H-Statements referred to under sections 2 and 3.

H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation. H336 May cause drowsiness or dizziness. H351 Suspected of causing cancer. H373 May cause damage to organs through prolonged or repeated exposure if inhaled.

Further information Copyright 2016 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

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Sigma-Aldrich - 270997 Page 1 of 7

SIGMA-ALDRICH sigma-aldrich.com Material Safety Data Sheet

Version 5.0 Revision Date 04/21/2012

Print Date 05/21/2012

1. PRODUCT AND COMPANY IDENTIFICATION

Product name : Dichloromethane

Product Number : 270997 Brand : Sigma-Aldrich Supplier : Sigma-Aldrich

3050 Spruce Street SAINT LOUIS MO 63103 USA

Telephone : +1 800-325-5832 Fax : +1 800-325-5052 Emergency Phone # (For both supplier and manufacturer)

: (314) 776-6555

Preparation Information : Sigma-Aldrich Corporation Product Safety - Americas Region 1-800-521-8956

2. HAZARDS IDENTIFICATION

Emergency Overview

OSHA Hazards Carcinogen, Target Organ Effect, Harmful by ingestion., Irritant

Target Organs

Liver, pancreas, Blood, Central nervous system, Heart, Kidney

GHS Classification Acute toxicity, Oral (Category 4) Skin irritation (Category 2) Eye irritation (Category 2B) Carcinogenicity (Category 2)

GHS Label elements, including precautionary statements

Pictogram

Signal word Warning

Hazard statement(s) H302 Harmful if swallowed. H315 + H320 Causes skin and eye irritation. H351 Suspected of causing cancer.

Precautionary statement(s) P281 Use personal protective equipment as required. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if

present and easy to do. Continue rinsing.

HMIS Classification Health hazard: 2 Chronic Health Hazard: * Flammability: 0 Physical hazards: 0

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NFPA Rating Health hazard: 2 Fire: 0 Reactivity Hazard: 0

Potential Health Effects

Inhalation May be harmful if inhaled. Causes respiratory tract irritation. Skin Harmful if absorbed through skin. Causes skin irritation. Eyes Causes eye irritation. Ingestion Harmful if swallowed.

3. COMPOSITION/INFORMATION ON INGREDIENTS

Synonyms : Methylene chloride

Formula : CH2Cl2

Molecular Weight : 84.93 g/mol

Component Concentration

Methylene chloride

CAS-No. EC-No. Index-No.

75-09-2 200-838-9 602-004-00-3

-

4. FIRST AID MEASURES

General advice Consult a physician. Show this safety data sheet to the doctor in attendance.Move out of dangerous area.

If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact Wash off with soap and plenty of water. Consult a physician.

In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

5. FIREFIGHTING MEASURES

Conditions of flammability Not flammable or combustible.

Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Special protective equipment for firefighters Wear self contained breathing apparatus for fire fighting if necessary.

Hazardous combustion products Hazardous decomposition products formed under fire conditions. - Carbon oxides, Hydrogen chloride gas

6. ACCIDENTAL RELEASE MEASURES

Personal precautions Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas.

Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

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Methods and materials for containment and cleaning up Soak up with inert absorbent material and dispose of as hazardous waste. Keep in suitable, closed containers for disposal.

7. HANDLING AND STORAGE

Precautions for safe handling Avoid contact with skin and eyes. Avoid inhalation of vapour or mist.

Conditions for safe storage Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

Heat sensitive. Store under inert gas.

8. EXPOSURE CONTROLS/PERSONAL PROTECTION

Components with workplace control parameters

Components CAS-No. Value Control parameters

Basis

Remarks Potential Occupational Carcinogen See Appendix A

Methylene chloride

75-09-2 TWA

50 ppm

USA. ACGIH Threshold Limit Values (TLV)

Central Nervous System impairment Carboxyhemoglobinemia Substances for which there is a Biological Exposure Index or Indices (see BEI® section) Confirmed animal carcinogen with unknown relevance to humans

Substance listed; for more information see OSHA document 1910.1052

See 1910.1052

Personal protective equipment

Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multi-purpose combination (US) or type AXBEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Hand protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.

Eye protection Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin and body protection Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Hygiene measures Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

9. PHYSICAL AND CHEMICAL PROPERTIES

Appearance

Form liquid

Colour colourless

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Safety data

pH no data available

Melting point/freezing point

Melting point/range: -97 °C (-143 °F)

Boiling point 39.8 - 40 °C (103.6 - 104 °F)

Flash point no data available

Ignition temperature 556.1 °C (1,033.0 °F)

Autoignition temperature

556.1 °C (1,033.0 °F)

662.0 °C (1,223.6 °F)

Lower explosion limit 12 %(V)

Upper explosion limit 19 %(V)

Vapour pressure 470.9 hPa (353.2 mmHg) at 20.0 °C (68.0 °F)

Density 1.325 g/mL at 25 °C (77 °F)

Water solubility slightly soluble

Partition coefficient: n-octanol/water

log Pow: 1.25

Relative vapour density

2.93 - (Air = 1.0)

Odour no data available

Odour Threshold no data available

Evaporation rate 0.71

10. STABILITY AND REACTIVITY

Chemical stability Stable under recommended storage conditions.

Possibility of hazardous reactions no data available

Conditions to avoid Heat, flames and sparks. Exposure to sunlight.

Materials to avoid Alkali metals, Aluminum, Strong oxidizing agents, Bases, Amines, Magnesium, Strong acids and strong bases, Vinyl compounds

Hazardous decomposition products Other decomposition products - no data available Hazardous decomposition products formed under fire conditions. - Carbon oxides, Hydrogen chloride gas Contains the following stabiliser(s): 2-Methyl-2-butene (>0.005 - <0.015 %)

11. TOXICOLOGICAL INFORMATION

Acute toxicity

Oral LD50 LD50 Oral - rat - 1,600 mg/kg Remarks: Behavioral:Ataxia.

Inhalation LC50 LC50 Inhalation - rat - 52,000 mg/m3

Dermal LD50 no data available

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Other information on acute toxicity no data available

Skin corrosion/irritation Skin - rabbit - Skin irritation - 24 h

Serious eye damage/eye irritation Eyes - rabbit - Mild eye irritation - 24 h

Respiratory or skin sensitization no data available

Germ cell mutagenicity

Genotoxicity in vivo - rat - Oral DNA damage

Carcinogenicity

Carcinogenicity - rat - Inhalation Tumorigenic:Carcinogenic by RTECS criteria. Endocrine:Tumors.

Limited evidence of carcinogenicity in animal studies

IARC: 2B - Group 2B: Possibly carcinogenic to humans (Methylene chloride)

NTP: Reasonably anticipated to be a human carcinogen (Methylene chloride)

Reproductive toxicity

no data available

Teratogenicity

Specific target organ toxicity - single exposure (Globally Harmonized System) no data available

Specific target organ toxicity - repeated exposure (Globally Harmonized System) no data available

Aspiration hazard no data available

Potential health effects

Inhalation May be harmful if inhaled. Causes respiratory tract irritation. Ingestion Harmful if swallowed. Skin Harmful if absorbed through skin. Causes skin irritation. Eyes Causes eye irritation.

Signs and Symptoms of Exposure Dichloromethane is metabolized in the body producing carbon monoxide which increases and sustains carboxyhemoglobin levels in the blood, reducing the oxygen-carrying capacity of the blood., Acts as a simple asphyxiant by displacing air., anesthetic effects, Difficulty in breathing, Headache, Dizziness, Prolonged or repeated contact with skin may cause:, defatting, Dermatitis, Contact with eyes can cause:, Redness, Blurred vision, Provokes tears., Effects due to ingestion may include:, Gastrointestinal discomfort, Central nervous system depression, Paresthesia., Drowsiness, Convulsions, Conjunctivitis., Pulmonary edema. Effects may be delayed., Irregular breathing., Stomach/intestinal disorders, Nausea, Vomiting, Increased liver enzymes., Weakness, Heavy or prolonged skin exposure may result in the absorption of harmful amounts of material., Abdominal pain

Synergistic effects no data available

Additional Information RTECS: PA8050000

12. ECOLOGICAL INFORMATION

Toxicity

Toxicity to fish LC50 - Pimephales promelas (fathead minnow) - 193.00 mg/l - 96 h

NOEC - Cyprinodon variegatus (sheepshead minnow) - 130 mg/l - 96 h

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Toxicity to daphnia and other aquatic invertebrates

EC50 - Daphnia magna (Water flea) - 1,682.00 mg/l - 48 h

Persistence and degradability no data available

Bioaccumulative potential no data available

Mobility in soil no data available

PBT and vPvB assessment no data available

Other adverse effects

no data available

13. DISPOSAL CONSIDERATIONS

Product Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.

Contaminated packaging Dispose of as unused product.

14. TRANSPORT INFORMATION

DOT (US) UN number: 1593 Class: 6.1 Packing group: III Proper shipping name: Dichloromethane Reportable Quantity (RQ): 1000 lbs Marine pollutant: No Poison Inhalation Hazard: No IMDG UN number: 1593 Class: 6.1 Packing group: III EMS-No: F-A, S-A Proper shipping name: DICHLOROMETHANE Marine pollutant: No IATA UN number: 1593 Class: 6.1 Packing group: III Proper shipping name: Dichloromethane

15. REGULATORY INFORMATION

OSHA Hazards Carcinogen, Target Organ Effect, Harmful by ingestion., Irritant

SARA 302 Components SARA 302: No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.

SARA 313 Components SARA 313: This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.

SARA 311/312 Hazards Acute Health Hazard, Chronic Health Hazard

Massachusetts Right To Know Components

Methylene chloride

CAS-No. 75-09-2

Revision Date 2007-07-01

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Pennsylvania Right To Know Components Methylene chloride

CAS-No. 75-09-2

Revision Date 2007-07-01

New Jersey Right To Know Components Methylene chloride

CAS-No. 75-09-2

Revision Date 2007-07-01

California Prop. 65 Components WARNING! This product contains a chemical known to the State of California to cause cancer. Methylene chloride

CAS-No. 75-09-2

Revision Date 2007-09-28

16. OTHER INFORMATION

Further information Copyright 2012 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

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Aldrich - D97754 Page 1 of 7

SIGMA-ALDRICH sigma-aldrich.com SAFETY DATA SHEET

according to Regulation (EC) No. 1907/2006 Version 6.0 Revision Date 31.03.2016

Print Date 10.11.2016 GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifiers Product name : Diethyl malonate

Product Number : D97754 Brand : Aldrich REACH No. : A registration number is not available for this substance as the substance

or its uses are exempted from registration, the annual tonnage does not require a registration or the registration is envisaged for a later registration deadline.

CAS-No. : 105-53-3

1.2 Relevant identified uses of the substance or mixture and uses advised against

Identified uses : Laboratory chemicals, Manufacture of substances

1.3 Details of the supplier of the safety data sheet

Company : Sigma-Aldrich Chemical Pvt Limited Industrial Area, Anekal Taluka Plot No 12, 12 Bommasandra - Jigani Link Road 560100 BANGALORE INDIA

1.4 Emergency telephone number

Emergency Phone # : +91 98802 05043

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture

Classification according to Regulation (EC) No 1272/2008 Eye irritation (Category 2), H319

For the full text of the H-Statements mentioned in this Section, see Section 16.

2.2 Label elements

Labelling according Regulation (EC) No 1272/2008 Pictogram

Signal word Warning Hazard statement(s) H319 Causes serious eye irritation. Precautionary statement(s) P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove

contact lenses, if present and easy to do. Continue rinsing. Supplemental Hazard Statements

none

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2.3 Other hazards This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

SECTION 3: Composition/information on ingredients

3.1 Substances Synonyms : Malonic acid diethyl ester

Formula : C7H12O4

Molecular weight : 160.17 g/mol CAS-No. : 105-53-3 EC-No. : 203-305-9 Hazardous ingredients according to Regulation (EC) No 1272/2008

Component Classification Concentration

Diethyl malonate

CAS-No. EC-No.

105-53-3 203-305-9

Eye Irrit. 2; H319 <= 100 %

For the full text of the H-Statements mentioned in this Section, see Section 16.

SECTION 4: First aid measures

4.1 Description of first aid measures

General advice Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact Wash off with soap and plenty of water. Consult a physician.

In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

4.2 Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

4.3 Indication of any immediate medical attention and special treatment needed No data available

SECTION 5: Firefighting measures

5.1 Extinguishing media

Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

5.2 Special hazards arising from the substance or mixture Carbon oxides

5.3 Advice for firefighters Wear self-contained breathing apparatus for firefighting if necessary.

5.4 Further information Use water spray to cool unopened containers.

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SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures Use personal protective equipment. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Beware of vapours accumulating to form explosive concentrations. Vapours can accumulate in low areas. For personal protection see section 8.

6.2 Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

6.3 Methods and materials for containment and cleaning up Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations (see section 13). Keep in suitable, closed containers for disposal.

6.4 Reference to other sections For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling Avoid contact with skin and eyes. Avoid inhalation of vapour or mist. Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic charge. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Combustible liquids

7.3 Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

8.1 Control parameters

8.2 Exposure controls

Appropriate engineering controls Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

Personal protective equipment

Eye/face protection Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Full contact Material: butyl-rubber Minimum layer thickness: 0.3 mm Break through time: 480 min Material tested:Butoject® (KCL 897 / Aldrich Z677647, Size M)

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Splash contact Material: Nature latex/chloroprene Minimum layer thickness: 0.6 mm Break through time: 30 min Material tested:Lapren® (KCL 706 / Aldrich Z677558, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail [email protected], test method: EN374 If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industria situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario. Body Protection Impervious clothing, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use (US) or type ABEK (EN 14387) respirator cartridges as a backup to enginee protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Control of environmental exposure Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties

a) Appearance Form: liquid Colour: colourless

b) Odour No data available

c) Odour Threshold No data available

d) pH No data available

e) Melting point/freezing point

Melting point/range: -51 - -50 °C - lit.

f) Initial boiling point and boiling range

199 °C - lit.

g) Flash point 90 °C - closed cup

h) Evaporation rate No data available

i) Flammability (solid, gas) No data available

j) Upper/lower flammability or explosive limits

No data available

k) Vapour pressure 1 mmHg at 40 °C

l) Vapour density 5.53 - (Air = 1.0)

m) Relative density 1.055 g/cm3 at 25 °C

n) Water solubility No data available

o) Partition coefficient: n-octanol/water

log Pow: 0.415

p) Auto-ignition temperature

No data available

q) Decomposition No data available

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Aldrich - D97754 Page 5 of 7

temperature

r) Viscosity No data available

s) Explosive properties No data available

t) Oxidizing properties No data available

9.2 Other safety information

Relative vapour density 5.53 - (Air = 1.0)

SECTION 10: Stability and reactivity

10.1 Reactivity No data available

10.2 Chemical stability Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions No data available

10.4 Conditions to avoid Heat, flames and sparks.

10.5 Incompatible materials acids, Bases, Oxidizing agents, Reducing agents

10.6 Hazardous decomposition products Hazardous decomposition products formed under fire conditions. - Carbon oxides Other decomposition products - No data available In the event of fire: see section 5

SECTION 11: Toxicological information

11.1 Information on toxicological effects

Acute toxicity LD50 Oral - Mouse - 6,400 mg/kg(Diethyl malonate) LD50 Dermal - Rabbit - > 16,880 mg/kg(Diethyl malonate)

Skin corrosion/irritation Skin - Rabbit(Diethyl malonate) Result: Mild skin irritation - 24 h

Serious eye damage/eye irritation No data available(Diethyl malonate)

Respiratory or skin sensitisation No data available(Diethyl malonate)

Germ cell mutagenicity No data available(Diethyl malonate)

Carcinogenicity

IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.

Reproductive toxicity No data available(Diethyl malonate)

Specific target organ toxicity - single exposure No data available(Diethyl malonate)

Specific target organ toxicity - repeated exposure No data available

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Aldrich - D97754 Page 6 of 7

Aspiration hazard No data available(Diethyl malonate)

Additional Information RTECS: Not available To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.(Diethyl malonate)

SECTION 12: Ecological information

12.1 Toxicity Toxicity to fish LC50 - Pimephales promelas (fathead minnow) - 10.8 mg/l - 96 h(Diethyl

malonate)

12.2 Persistence and degradability Biodegradability aerobic - Exposure time 28 d(Diethyl malonate)

Result: 99 % - Readily biodegradable

12.3 Bioaccumulative potential No data available

12.4 Mobility in soil No data available(Diethyl malonate)

12.5 Results of PBT and vPvB assessment This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

12.6 Other adverse effects Harmful to aquatic life. No data available

SECTION 13: Disposal considerations

13.1 Waste treatment methods

Product This combustible material may be burned in a chemical incinerator equipped with an afterburner and scrubber. Offer surplus and non-recyclable solutions to a licensed disposal company.

Contaminated packaging Dispose of as unused product.

SECTION 14: Transport information

14.1 UN number ADR/RID: - IMDG: - IATA: -

14.2 UN proper shipping name ADR/RID: Not dangerous goods IMDG: Not dangerous goods IATA: Not dangerous goods

14.3 Transport hazard class(es) ADR/RID: - IMDG: - IATA: -

14.4 Packaging group ADR/RID: - IMDG: - IATA: -

14.5 Environmental hazards ADR/RID: no IMDG Marine pollutant: no IATA: no

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14.6 Special precautions for user No data available

SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

15.2 Chemical safety assessment For this product a chemical safety assessment was not carried out

SECTION 16: Other information

Full text of H-Statements referred to under sections 2 and 3.

H319 Causes serious eye irritation.

Further information Copyright 2016 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

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Sigma-Aldrich - 386464 Page 1 of 8

SIGMA-ALDRICH sigma-aldrich.com SAFETY DATA SHEET

according to Regulation (EC) No. 1907/2006 Version 6.0 Revision Date 30.03.2016

Print Date 10.11.2016 GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifiers Product name : Diisopropylamine

Product Number : 386464 Brand : Sigma-Aldrich Index-No. : 612-129-00-5 REACH No. : A registration number is not available for this substance as the substance

or its uses are exempted from registration, the annual tonnage does not require a registration or the registration is envisaged for a later registration deadline.

CAS-No. : 108-18-9

1.2 Relevant identified uses of the substance or mixture and uses advised against

Identified uses : Laboratory chemicals, Manufacture of substances

1.3 Details of the supplier of the safety data sheet

Company : Sigma-Aldrich Chemical Pvt Limited Industrial Area, Anekal Taluka Plot No 12, 12 Bommasandra - Jigani Link Road 560100 BANGALORE INDIA

1.4 Emergency telephone number

Emergency Phone # : +91 98802 05043

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture

Classification according to Regulation (EC) No 1272/2008 Flammable liquids (Category 2), H225 Acute toxicity, Oral (Category 4), H302 Acute toxicity, Inhalation (Category 3), H331 Skin corrosion (Category 1A), H314

For the full text of the H-Statements mentioned in this Section, see Section 16.

2.2 Label elements

Labelling according Regulation (EC) No 1272/2008 Pictogram

Signal word Danger Hazard statement(s) H225 Highly flammable liquid and vapour. H302 Harmful if swallowed. H314 Causes severe skin burns and eye damage.

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H331 Toxic if inhaled. Precautionary statement(s) P210 Keep away from heat, hot surfaces, sparks, open flames and other

ignition sources. No smoking. P280 Wear protective gloves/ protective clothing/ eye protection/ face

protection. P303 + P361 + P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing.

Rinse skin with water/shower. P304 + P340 + P310 IF INHALED: Remove person to fresh air and keep comfortable for

breathing. Immediately call a POISON CENTER/doctor. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove

contact lenses, if present and easy to do. Continue rinsing. P403 + P233 Store in a well-ventilated place. Keep container tightly closed. Supplemental Hazard Statements

none

2.3 Other hazards This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher. Lachrymator., Rapidly absorbed through skin.

SECTION 3: Composition/information on ingredients

3.1 Substances Synonyms : DIPA

Formula : C<SB>6</>H<SB>15</>N Molecular weight : 101.19 g/mol CAS-No. : 108-18-9 EC-No. : 203-558-5 Index-No. : 612-129-00-5 Hazardous ingredients according to Regulation (EC) No 1272/2008

Component Classification Concentration

Diisopropylamine

CAS-No. EC-No. Index-No.

108-18-9 203-558-5 612-129-00-5

Flam. Liq. 2; Acute Tox. 4; Acute Tox. 3; Skin Corr. 1A; H225, H302, H331, H314 Concentration limits: >= 5 %: STOT SE 3, H335;

<= 100 %

For the full text of the H-Statements mentioned in this Section, see Section 16.

SECTION 4: First aid measures

4.1 Description of first aid measures

General advice Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact Take off contaminated clothing and shoes immediately. Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician.

In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

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If swallowed Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

4.2 Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

4.3 Indication of any immediate medical attention and special treatment needed No data available

SECTION 5: Firefighting measures

5.1 Extinguishing media

Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

5.2 Special hazards arising from the substance or mixture Carbon oxides, Nitrogen oxides (NOx) Flash back possible over considerable distance., Container explosion may occur under fire conditions.

5.3 Advice for firefighters Wear self-contained breathing apparatus for firefighting if necessary.

5.4 Further information Use water spray to cool unopened containers.

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures Wear respiratory protection. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to form explosive concentrations. Vapours can accumulate in low areas. For personal protection see section 8.

6.2 Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

6.3 Methods and materials for containment and cleaning up Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations (see section 13).

6.4 Reference to other sections For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling Avoid contact with skin and eyes. Avoid inhalation of vapour or mist. Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic charge. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Storage class (TRGS 510): Flammable liquids

7.3 Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

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SECTION 8: Exposure controls/personal protection

8.1 Control parameters

8.2 Exposure controls

Appropriate engineering controls Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product.

Personal protective equipment

Eye/face protection Tightly fitting safety goggles. Faceshield (8-inch minimum). Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Full contact Material: Nitrile rubber Minimum layer thickness: 0.4 mm Break through time: 480 min Material tested:Camatril® (KCL 730 / Aldrich Z677442, Size M) Splash contact Material: Nitrile rubber Minimum layer thickness: 0.4 mm Break through time: 480 min Material tested:Camatril® (KCL 730 / Aldrich Z677442, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail [email protected], test method: EN374 If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industria situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario. Body Protection Complete suit protecting against chemicals, Flame retardant antistatic protective clothing., The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use (US) or type ABEK (EN 14387) respirator cartridges as a backup to enginee protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Control of environmental exposure Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties

a) Appearance Form: liquid, clear Colour: colourless

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b) Odour Ammonia odor

c) Odour Threshold No data available

d) pH No data available

e) Melting point/freezing point

Melting point/range: -61 °C

f) Initial boiling point and boiling range

84 °C

g) Flash point -16.99 °C - closed cup

h) Evaporation rate No data available

i) Flammability (solid, gas) No data available

j) Upper/lower flammability or explosive limits

Upper explosion limit: 8.5 %(V) Lower explosion limit: 1.1 %(V)

k) Vapour pressure 50 mmHg at 20 °C

l) Vapour density 3.49 - (Air = 1.0)

m) Relative density 0.722 g/mL at 25 °C

n) Water solubility 110 g/l at 25 °C - completely soluble

o) Partition coefficient: n-octanol/water

log Pow: 0.4 at 20 °C

p) Auto-ignition temperature

295 °C at 1,007 hPa

q) Decomposition temperature

No data available

r) Viscosity No data available

s) Explosive properties No data available

t) Oxidizing properties No data available

9.2 Other safety information

Relative vapour density 3.49 - (Air = 1.0)

SECTION 10: Stability and reactivity

10.1 Reactivity No data available

10.2 Chemical stability Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions No data available

10.4 Conditions to avoid Heat, flames and sparks.

10.5 Incompatible materials Strong acids, Strong bases, Strong oxidizing agents, Plastics

10.6 Hazardous decomposition products Hazardous decomposition products formed under fire conditions. - Carbon oxides, Nitrogen oxides (NOx) Other decomposition products - No data available In the event of fire: see section 5

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Sigma-Aldrich - 386464 Page 6 of 8

SECTION 11: Toxicological information

11.1 Information on toxicological effects

Acute toxicity LD50 Oral - Rat - male and female - 420 mg/kg(Diisopropylamine) LC50 Inhalation - Rat - male and female - 4 h - 5.35 mg/l(Diisopropylamine) (OECD Test Guideline 403) LD50 Dermal - Rabbit - > 10,000 mg/kg(Diisopropylamine)

Skin corrosion/irritation Skin - Rabbit(Diisopropylamine) Result: Causes severe burns. - 3 min (OECD Test Guideline 404)

Serious eye damage/eye irritation Eyes - Rabbit(Diisopropylamine) Result: Risk of serious damage to eyes. - 24 h (OECD Test Guideline 405)

Respiratory or skin sensitisation Maximisation Test - Guinea pig(Diisopropylamine) Result: Does not cause skin sensitisation. (OECD Test Guideline 406)

Germ cell mutagenicity Mouse(Diisopropylamine) lymphocyte Result: negative

Carcinogenicity

IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.

Reproductive toxicity

No data available(Diisopropylamine)

Specific target organ toxicity - single exposure No data available(Diisopropylamine)

Specific target organ toxicity - repeated exposure No data available

Aspiration hazard No data available(Diisopropylamine)

Additional Information

Repeated dose toxicity - Rat - male and female - Oral - No observed adverse effect level - 50 mg/kg(Diisopropylamine)

Repeated dose toxicity - Rat - male and female - No observed adverse effect level - >= 150 mg/kg(Diisopropylamine) RTECS: IM4025000 burning sensation, Cough, wheezing, laryngitis, Shortness of breath, spasm, inflammation and edema of the larynx, spasm, inflammation and edema of the bronchi, pneumonitis, pulmonary edema, Material is extremely destructive to tissue of the mucous membranes and upper respiratory tract, eyes, and skin., To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.(Diisopropylamine) Liver - Irregularities - Based on Human Evidence(Diisopropylamine)

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Sigma-Aldrich - 386464 Page 7 of 8

SECTION 12: Ecological information

12.1 Toxicity Toxicity to fish semi-static test LC50 - Gasterosteus aculeatus - 798 mg/l - 96

h(Diisopropylamine) Toxicity to daphnia and other aquatic invertebrates

static test LC50 - Daphnia magna (Water flea) - 110 mg/l - 48 h(Diisopropylamine)

Toxicity to algae static test EC50 - SELENASTRUM - 20 mg/l - 96 h(Diisopropylamine) Toxicity to bacteria Respiration inhibition EC50 - activated sludge - > 100 mg/l - 3

h(Diisopropylamine) (OECD Test Guideline 209)

12.2 Persistence and degradability Biodegradability aerobic - Exposure time 28 d(Diisopropylamine)

Result: 11 % - Not readily biodegradable. (OECD Test Guideline 301D)

12.3 Bioaccumulative potential No data available

12.4 Mobility in soil No data available(Diisopropylamine)

12.5 Results of PBT and vPvB assessment This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

12.6 Other adverse effects Harmful to aquatic life.

SECTION 13: Disposal considerations

13.1 Waste treatment methods

Product Burn in a chemical incinerator equipped with an afterburner and scrubber b highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company.

Contaminated packaging Dispose of as unused product.

SECTION 14: Transport information

14.1 UN number ADR/RID: 1158 IMDG: 1158 IATA: 1158

14.2 UN proper shipping name ADR/RID: DIISOPROPYLAMINE IMDG: DIISOPROPYLAMINE IATA: Diisopropylamine

14.3 Transport hazard class(es) ADR/RID: 3 (8) IMDG: 3 (8) IATA: 3 (8)

14.4 Packaging group ADR/RID: II IMDG: II IATA: II

14.5 Environmental hazards ADR/RID: no IMDG Marine pollutant: no IATA: no

14.6 Special precautions for user No data available

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Sigma-Aldrich - 386464 Page 8 of 8

SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

15.2 Chemical safety assessment For this product a chemical safety assessment was not carried out

SECTION 16: Other information

Full text of H-Statements referred to under sections 2 and 3.

H225 Highly flammable liquid and vapour. H302 Harmful if swallowed. H314 Causes severe skin burns and eye damage. H331 Toxic if inhaled. H335 May cause respiratory irritation.

Further information Copyright 2016 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

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Sigma-Aldrich - 227056 Page 1 of 8

SIGMA-ALDRICH sigma-aldrich.com SAFETY DATA SHEET

according to Regulation (EC) No. 1907/2006 Version 6.0 Revision Date 30.03.2016

Print Date 10.11.2016 GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifiers Product name : N,N-Dimethylformamide

Product Number : 227056 Brand : Sigma-Aldrich Index-No. : 616-001-00-X REACH No. : 01-2119475605-32-XXXX

CAS-No. : 68-12-2

1.2 Relevant identified uses of the substance or mixture and uses advised against

Identified uses : Laboratory chemicals, Manufacture of substances

1.3 Details of the supplier of the safety data sheet

Company : Sigma-Aldrich Chemical Pvt Limited Industrial Area, Anekal Taluka Plot No 12, 12 Bommasandra - Jigani Link Road 560100 BANGALORE INDIA

1.4 Emergency telephone number

Emergency Phone # : +91 98802 05043

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture

Classification according to Regulation (EC) No 1272/2008 Flammable liquids (Category 3), H226 Acute toxicity, Inhalation (Category 4), H332 Acute toxicity, Dermal (Category 4), H312 Eye irritation (Category 2), H319 Reproductive toxicity (Category 1B), H360D

For the full text of the H-Statements mentioned in this Section, see Section 16.

2.2 Label elements

Labelling according Regulation (EC) No 1272/2008 Pictogram

Signal word Danger Hazard statement(s) H226 Flammable liquid and vapour. H312 + H332 Harmful in contact with skin or if inhaled H319 Causes serious eye irritation. H360D May damage the unborn child.

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Precautionary statement(s) P201 Obtain special instructions before use. P210 Keep away from heat, hot surfaces, sparks, open flames and other

ignition sources. No smoking. P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P280 Wear protective gloves/ protective clothing/ eye protection/ face

protection. P308 + P313 IF exposed or concerned: Get medical advice/ attention. P370 + P378 In case of fire: Use dry powder or dry sand to extinguish. Supplemental Hazard Statements

none

2.3 Other hazards This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher. Rapidly absorbed through skin.

SECTION 3: Composition/information on ingredients

3.1 Substances Synonyms : DMF

Formula : C3H7NO

Molecular weight : 73.09 g/mol CAS-No. : 68-12-2 EC-No. : 200-679-5 Index-No. : 616-001-00-X Registration number : 01-2119475605-32-XXXX

Hazardous ingredients according to Regulation (EC) No 1272/2008

Component Classification Concentration

N,N-Dimethylformamide Included in the Candidate List of Substances of Very High Concern (SVHC) according to Regulation (EC) No. 1907/2006 (REACH)

CAS-No. EC-No. Index-No. Registration number

68-12-2 200-679-5 616-001-00-X 01-2119475605-32-XXXX

Flam. Liq. 3; Acute Tox. 4; Eye Irrit. 2; Repr. 1B; H226, H332, H312, H319, H360

<= 100 %

For the full text of the H-Statements mentioned in this Section, see Section 16.

SECTION 4: First aid measures

4.1 Description of first aid measures

General advice Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact Wash off with soap and plenty of water. Consult a physician.

In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

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4.2 Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

4.3 Indication of any immediate medical attention and special treatment needed No data available

SECTION 5: Firefighting measures

5.1 Extinguishing media

Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

5.2 Special hazards arising from the substance or mixture Carbon oxides, Nitrogen oxides (NOx)

5.3 Advice for firefighters Wear self-contained breathing apparatus for firefighting if necessary.

5.4 Further information Use water spray to cool unopened containers.

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures Use personal protective equipment. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to form explosive concentrations. Vapours can accumulate in low areas. For personal protection see section 8.

6.2 Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

6.3 Methods and materials for containment and cleaning up Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations (see section 13).

6.4 Reference to other sections For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling Avoid exposure - obtain special instructions before use.Avoid contact with skin and eyes. Avoid inhalation of vapour or mist. Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic charge. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

Handle and store under inert gas. Storage class (TRGS 510): Flammable liquids

7.3 Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

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SECTION 8: Exposure controls/personal protection

8.1 Control parameters

Derived No Effect Level (DNEL)

Application Area Exposure routes

Health effect Value

Workers Skin contact Acute systemic effects 26.3mg/kg BW/d

Workers Inhalation Acute systemic effects 30 mg/m3

Workers Skin contact Long-term systemic effects 3.31mg/kg BW/d

Workers Inhalation Long-term systemic effects 15 mg/m3

Workers Inhalation Long-term local effects 15 mg/m3

Workers Inhalation Acute local effects 30 mg/m3

Predicted No Effect Concentration (PNEC)

Compartment Value

Water 30 mg/l

Soil 16.235 mg/kg

Marine water 3 mg/kg

Fresh water 30 mg/l

Fresh water sediment 25.05 mg/kg

Onsite sewage treatment plant 123 mg/l

8.2 Exposure controls

Appropriate engineering controls Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

Personal protective equipment

Eye/face protection Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Full contact Material: butyl-rubber Minimum layer thickness: 0.3 mm Break through time: 480 min Material tested:Butoject® (KCL 897 / Aldrich Z677647, Size M) Splash contact Material: Nature latex/chloroprene Minimum layer thickness: 0.6 mm Break through time: 65 min Material tested:Lapren® (KCL 706 / Aldrich Z677558, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail [email protected], test method: EN374 If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industria situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario.

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Body Protection Complete suit protecting against chemicals, Flame retardant antistatic protective clothing., The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use (US) or type ABEK (EN 14387) respirator cartridges as a backup to enginee protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Control of environmental exposure Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties

a) Appearance Form: liquid, clear Colour: colourless

b) Odour amine-like

c) Odour Threshold No data available

d) pH 6.7

e) Melting point/freezing point

Melting point/range: -61 °C

f) Initial boiling point and boiling range

153 °C

g) Flash point 58 °C - closed cup

h) Evaporation rate No data available

i) Flammability (solid, gas) No data available

j) Upper/lower flammability or explosive limits

Upper explosion limit: 15.2 %(V) Lower explosion limit: 2.2 %(V)

k) Vapour pressure 2.70 mmHg at 20 °C 3.87 mmHg at 25 °C

l) Vapour density 2.52 - (Air = 1.0)

m) Relative density 0.944 g/mL

n) Water solubility completely miscible

o) Partition coefficient: n-octanol/water

log Pow: -1.01

p) Auto-ignition temperature

No data available

q) Decomposition temperature

No data available

r) Viscosity No data available

s) Explosive properties No data available

t) Oxidizing properties No data available

9.2 Other safety information

Relative vapour density 2.52 - (Air = 1.0)

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SECTION 10: Stability and reactivity

10.1 Reactivity No data available

10.2 Chemical stability Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions No data available

10.4 Conditions to avoid Heat, flames and sparks.

10.5 Incompatible materials Strong oxidizing agents

10.6 Hazardous decomposition products Hazardous decomposition products formed under fire conditions. - Carbon oxides, Nitrogen oxides (NOx) Other decomposition products - No data available In the event of fire: see section 5

SECTION 11: Toxicological information

11.1 Information on toxicological effects

Acute toxicity LD50 Oral - Rat - 2,800 mg/kg(N,N-Dimethylformamide) LC50 Inhalation - Rat - 4 h - 9 - 15 mg/l(N,N-Dimethylformamide) LD50 Dermal - Rabbit - 1,500 mg/kg(N,N-Dimethylformamide)

Skin corrosion/irritation Skin - Human(N,N-Dimethylformamide) Result: Mild skin irritation - 24 h

Serious eye damage/eye irritation Eyes - Rabbit(N,N-Dimethylformamide) Result: Moderate eye irritation

Respiratory or skin sensitisation No data available(N,N-Dimethylformamide)

Germ cell mutagenicity Mouse(N,N-Dimethylformamide) lymphocyte Mutation in mammalian somatic cells.

Carcinogenicity This product is or contains a component that is not classifiable as to its classification.(N,N-Dimethylformamide)

IARC: 3 - Group 3: Not classifiable as to its carcinogenicity to humans (N,N-Dimethylformamide)

Reproductive toxicity May cause congenital malformation in the fetus.(N,N-Dimethylformamide)

Specific target organ toxicity - single exposure No data available(N,N-Dimethylformamide)

Specific target organ toxicity - repeated exposure No data available

Aspiration hazard No data available(N,N-Dimethylformamide)

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Additional Information RTECS: LQ2100000 Warning: intolerance for alcohol can occur up to 4 days after dimethylform a potent liver toxin., Vomiting, Diarrhoea, Abdominal pain, To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.(N,N-Dimethylformamide)

SECTION 12: Ecological information

12.1 Toxicity Toxicity to fish LC50 - Oncorhynchus mykiss (rainbow trout) - 9,000 - 13,000 mg/l - 96 h(N,N-

Dimethylformamide) LC50 - Lepomis macrochirus (Bluegill) - 6,700 - 7,500 mg/l - 96 h(N,N-

Dimethylformamide) LC50 - Pimephales promelas (fathead minnow) - 10,400 - 10,800 mg/l - 96

h(N,N-Dimethylformamide) LC50 - Oncorhynchus mykiss (rainbow trout) - 9,800 mg/l - 96 h(N,N-

Dimethylformamide) LC50 - Lepomis macrochirus (Bluegill) - 6,300 mg/l - 96 h(N,N-

Dimethylformamide) LC50 - Pimephales promelas (fathead minnow) - 10,600 mg/l - 96 h(N,N-

Dimethylformamide) Toxicity to daphnia and other aquatic invertebrates

EC50 - Daphnia magna (Water flea) - 9,600 - 13,100 mg/l - 48 h(N,N-Dimethylformamide)

EC50 - Daphnia magna (Water flea) - 15,700 mg/l - 48 h(N,N-

Dimethylformamide) Toxicity to algae LC50 - Desmodesmus subspicatus (green algae) - > 500 mg/l - 96 h(N,N-

Dimethylformamide)

12.2 Persistence and degradability Biodegradability Result: > 90 % - Readily biodegradable

12.3 Bioaccumulative potential No data available

12.4 Mobility in soil No data available(N,N-Dimethylformamide)

12.5 Results of PBT and vPvB assessment This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

12.6 Other adverse effects No data available

SECTION 13: Disposal considerations

13.1 Waste treatment methods

Product Burn in a chemical incinerator equipped with an afterburner and scrubber b highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company.

Contaminated packaging Dispose of as unused product.

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SECTION 14: Transport information

14.1 UN number ADR/RID: 2265 IMDG: 2265 IATA: 2265

14.2 UN proper shipping name ADR/RID: N,N-DIMETHYLFORMAMIDE IMDG: N,N-DIMETHYLFORMAMIDE IATA: N,N-Dimethylformamide

14.3 Transport hazard class(es) ADR/RID: 3 IMDG: 3 IATA: 3

14.4 Packaging group ADR/RID: III IMDG: III IATA: III

14.5 Environmental hazards ADR/RID: no IMDG Marine pollutant: no IATA: no

14.6 Special precautions for user No data available

SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

Authorisations and/or restrictions on use 15.2 Chemical safety assessment

A Chemical Safety Assessment has been carried out for this substance.

SECTION 16: Other information

Full text of H-Statements referred to under sections 2 and 3.

H226 Flammable liquid and vapour. H312 Harmful in contact with skin. H312 + H332 Harmful in contact with skin or if inhaled H319 Causes serious eye irritation. H332 Harmful if inhaled. H360 May damage fertility or the unborn child. H360D May damage the unborn child.

Further information Copyright 2016 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

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SIGMA-ALDRICH sigma-aldrich.com SAFETY DATA SHEET

according to Regulation (EC) No. 1907/2006 Version 6.0 Revision Date 31.03.2016

Print Date 10.11.2016 GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifiers Product name : Dimethylamine hydrochloride

Product Number : 126365 Brand : Aldrich REACH No. : A registration number is not available for this substance as the substance

or its uses are exempted from registration, the annual tonnage does not require a registration or the registration is envisaged for a later registration deadline.

CAS-No. : 506-59-2

1.2 Relevant identified uses of the substance or mixture and uses advised against

Identified uses : Laboratory chemicals, Manufacture of substances

1.3 Details of the supplier of the safety data sheet

Company : Sigma-Aldrich Chemical Pvt Limited Industrial Area, Anekal Taluka Plot No 12, 12 Bommasandra - Jigani Link Road 560100 BANGALORE INDIA

1.4 Emergency telephone number

Emergency Phone # : +91 98802 05043

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture

Classification according to Regulation (EC) No 1272/2008 Acute toxicity, Oral (Category 4), H302 Skin irritation (Category 2), H315 Eye irritation (Category 2), H319 Specific target organ toxicity - single exposure (Category 3), Respiratory system, H335

For the full text of the H-Statements mentioned in this Section, see Section 16.

2.2 Label elements

Labelling according Regulation (EC) No 1272/2008 Pictogram

Signal word Warning Hazard statement(s) H302 Harmful if swallowed. H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation.

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Precautionary statement(s) P261 Avoid breathing dust. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove

contact lenses, if present and easy to do. Continue rinsing. Supplemental Hazard Statements

none

2.3 Other hazards This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

SECTION 3: Composition/information on ingredients

3.1 Substances Formula : C2H7N · HCl

Molecular weight : 81.54 g/mol CAS-No. : 506-59-2 EC-No. : 208-046-5 Hazardous ingredients according to Regulation (EC) No 1272/2008

Component Classification Concentration

Dimethylammonium chloride

CAS-No. EC-No.

506-59-2 208-046-5

Acute Tox. 4; Skin Irrit. 2; Eye Irrit. 2; STOT SE 3; H302, H315, H319, H335

<= 100 %

For the full text of the H-Statements mentioned in this Section, see Section 16.

SECTION 4: First aid measures

4.1 Description of first aid measures

General advice Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact Wash off with soap and plenty of water. Consult a physician.

In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

4.2 Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

4.3 Indication of any immediate medical attention and special treatment needed No data available

SECTION 5: Firefighting measures

5.1 Extinguishing media

Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

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5.2 Special hazards arising from the substance or mixture Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

5.3 Advice for firefighters Wear self-contained breathing apparatus for firefighting if necessary.

5.4 Further information No data available

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions Do not let product enter drains.

6.3 Methods and materials for containment and cleaning up Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.

6.4 Reference to other sections For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

hygroscopic Storage class (TRGS 510): Non Combustible Solids

7.3 Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

8.1 Control parameters

8.2 Exposure controls

Appropriate engineering controls Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

Personal protective equipment

Eye/face protection Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Full contact

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Material: Nitrile rubber Minimum layer thickness: 0.11 mm Break through time: 480 min Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M) Splash contact Material: Nitrile rubber Minimum layer thickness: 0.11 mm Break through time: 480 min Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail [email protected], test method: EN374 If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industria situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario. Body Protection Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection For nuisance exposures use type P95 (US) or type P1 (EU EN 143) particle r (US) or type ABEK-P2 (EU EN 143) respirator cartridges. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Control of environmental exposure Do not let product enter drains.

SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties

a) Appearance Form: crystalline Colour: colourless

b) Odour No data available

c) Odour Threshold No data available

d) pH No data available

e) Melting point/freezing point

Melting point/range: 170 - 173 °C - lit.

f) Initial boiling point and boiling range

No data available

g) Flash point No data available

h) Evaporation rate No data available

i) Flammability (solid, gas) No data available

j) Upper/lower flammability or explosive limits

No data available

k) Vapour pressure No data available

l) Vapour density No data available

m) Relative density No data available

n) Water solubility No data available

o) Partition coefficient: n-octanol/water

No data available

p) Auto-ignition No data available

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temperature

q) Decomposition temperature

No data available

r) Viscosity No data available

s) Explosive properties No data available

t) Oxidizing properties No data available

9.2 Other safety information No data available

SECTION 10: Stability and reactivity

10.1 Reactivity No data available

10.2 Chemical stability Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions No data available

10.4 Conditions to avoid hygroscopic

10.5 Incompatible materials Oxidizing agents

10.6 Hazardous decomposition products Hazardous decomposition products formed under fire conditions. - Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas Other decomposition products - No data available In the event of fire: see section 5

SECTION 11: Toxicological information

11.1 Information on toxicological effects

Acute toxicity LD50 Oral - Rat - 1,070 mg/kg(Dimethylammonium chloride)

Skin corrosion/irritation No data available(Dimethylammonium chloride)

Serious eye damage/eye irritation No data available(Dimethylammonium chloride)

Respiratory or skin sensitisation No data available(Dimethylammonium chloride)

Germ cell mutagenicity No data available(Dimethylammonium chloride)

Carcinogenicity

IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.

Reproductive toxicity

Specific target organ toxicity - single exposure Inhalation - May cause respiratory irritation.(Dimethylammonium chloride)

Specific target organ toxicity - repeated exposure No data available

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Aspiration hazard No data available(Dimethylammonium chloride)

Additional Information RTECS: IQ0220000 To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.(Dimethylammonium chloride)

SECTION 12: Ecological information

12.1 Toxicity No data available

12.2 Persistence and degradability No data available

12.3 Bioaccumulative potential No data available

12.4 Mobility in soil No data available(Dimethylammonium chloride)

12.5 Results of PBT and vPvB assessment This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

12.6 Other adverse effects No data available

SECTION 13: Disposal considerations

13.1 Waste treatment methods

Product Offer surplus and non-recyclable solutions to a licensed disposal company. Dissolve or mix the material with a combustible solvent and burn in a chem scrubber.

Contaminated packaging Dispose of as unused product.

SECTION 14: Transport information

14.1 UN number ADR/RID: - IMDG: - IATA: -

14.2 UN proper shipping name ADR/RID: Not dangerous goods IMDG: Not dangerous goods IATA: Not dangerous goods

14.3 Transport hazard class(es) ADR/RID: - IMDG: - IATA: -

14.4 Packaging group ADR/RID: - IMDG: - IATA: -

14.5 Environmental hazards ADR/RID: no IMDG Marine pollutant: no IATA: no

14.6 Special precautions for user No data available

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SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

15.2 Chemical safety assessment For this product a chemical safety assessment was not carried out

SECTION 16: Other information

Full text of H-Statements referred to under sections 2 and 3.

H302 Harmful if swallowed. H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation.

Further information Copyright 2016 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

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Aldrich - 522805 Page 1 of 7

SIGMA-ALDRICH sigma-aldrich.com SAFETY DATA SHEET

according to Regulation (EC) No. 1907/2006 Version 6.0 Revision Date 30.03.2016

Print Date 10.11.2016 GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifiers Product name : 4-(Dimethylamino)pyridine

Product Number : 522805 Brand : Aldrich REACH No. : A registration number is not available for this substance as the substance

or its uses are exempted from registration, the annual tonnage does not require a registration or the registration is envisaged for a later registration deadline.

CAS-No. : 1122-58-3

1.2 Relevant identified uses of the substance or mixture and uses advised against

Identified uses : Laboratory chemicals, Manufacture of substances

1.3 Details of the supplier of the safety data sheet

Company : Sigma-Aldrich Chemical Pvt Limited Industrial Area, Anekal Taluka Plot No 12, 12 Bommasandra - Jigani Link Road 560100 BANGALORE INDIA

1.4 Emergency telephone number

Emergency Phone # : +91 98802 05043

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture

Classification according to Regulation (EC) No 1272/2008 Acute toxicity, Oral (Category 3), H301 Acute toxicity, Dermal (Category 2), H310 Skin irritation (Category 2), H315 Eye irritation (Category 2), H319 Specific target organ toxicity - single exposure (Category 3), Respiratory system, H335

For the full text of the H-Statements mentioned in this Section, see Section 16.

2.2 Label elements

Labelling according Regulation (EC) No 1272/2008 Pictogram

Signal word Danger Hazard statement(s) H301 Toxic if swallowed. H310 Fatal in contact with skin. H315 Causes skin irritation.

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H319 Causes serious eye irritation. H335 May cause respiratory irritation. Precautionary statement(s) P280 Wear protective gloves/ protective clothing/ eye protection/ face

protection. P301 + P310 + P330 IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse

mouth. P302 + P352 + P310 IF ON SKIN: Wash with plenty of water. Immediately call a POISON

CENTER/doctor. P304 + P340 + P312 IF INHALED: Remove person to fresh air and keep comfortable for

breathing. Call a POISON CENTER/doctor if you feel unwell. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove

contact lenses, if present and easy to do. Continue rinsing. P337 + P313 If eye irritation persists: Get medical advice/ attention. Supplemental Hazard Statements

none

2.3 Other hazards This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

SECTION 3: Composition/information on ingredients

3.1 Substances Synonyms : DMAP

Formula : C7H10N2

Molecular weight : 122.17 g/mol CAS-No. : 1122-58-3 EC-No. : 214-353-5 Hazardous ingredients according to Regulation (EC) No 1272/2008

Component Classification Concentration

N,N-Dimethylpyridin-4-amine

CAS-No. EC-No.

1122-58-3 214-353-5

Acute Tox. 3; Acute Tox. 2; Skin Irrit. 2; Eye Irrit. 2; STOT SE 3; H301, H310, H315, H319, H335

<= 100 %

For the full text of the H-Statements mentioned in this Section, see Section 16.

SECTION 4: First aid measures

4.1 Description of first aid measures

General advice Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician.

In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

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4.2 Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

4.3 Indication of any immediate medical attention and special treatment needed No data available

SECTION 5: Firefighting measures

5.1 Extinguishing media

Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

5.2 Special hazards arising from the substance or mixture Carbon oxides, Nitrogen oxides (NOx)

5.3 Advice for firefighters Wear self-contained breathing apparatus for firefighting if necessary.

5.4 Further information No data available

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures Wear respiratory protection. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

6.3 Methods and materials for containment and cleaning up Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.

6.4 Reference to other sections For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

7.3 Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

8.1 Control parameters

8.2 Exposure controls

Appropriate engineering controls Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product.

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Personal protective equipment

Eye/face protection Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Full contact Material: Nitrile rubber Minimum layer thickness: 0.11 mm Break through time: 480 min Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M) Splash contact Material: Nitrile rubber Minimum layer thickness: 0.11 mm Break through time: 480 min Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail [email protected], test method: EN374 If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industria situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario. Body Protection Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use (EN 143) respirator cartridges as a backup to engineering controls. If th full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Control of environmental exposure Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties

a) Appearance Form: crystalline Colour: beige

b) Odour No data available

c) Odour Threshold No data available

d) pH 11.14 at 5 °C

e) Melting point/freezing point

Melting point/range: 108 - 110 °C

f) Initial boiling point and boiling range

162 °C at 67 hPa

g) Flash point 110 °C - closed cup

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h) Evaporation rate No data available

i) Flammability (solid, gas) No data available

j) Upper/lower flammability or explosive limits

No data available

k) Vapour pressure 0.169 hPa at 25 °C

l) Vapour density No data available

m) Relative density No data available

n) Water solubility 76 g/l at 20 °C

o) Partition coefficient: n-octanol/water

log Pow: 1.34

p) Auto-ignition temperature

420 °C

q) Decomposition temperature

No data available

r) Viscosity No data available

s) Explosive properties No data available

t) Oxidizing properties No data available

9.2 Other safety information

Dissociation constant 10.14 at 5 °C

SECTION 10: Stability and reactivity

10.1 Reactivity No data available

10.2 Chemical stability Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions No data available

10.4 Conditions to avoid No data available

10.5 Incompatible materials acids, Oxidizing agents

10.6 Hazardous decomposition products Other decomposition products - No data available Hazardous decomposition products formed under fire conditions. - Carbon oxides, Nitrogen oxides (NOx) In the event of fire: see section 5

SECTION 11: Toxicological information

11.1 Information on toxicological effects

Acute toxicity LD50 Oral - Rat - 140 mg/kg(N,N-Dimethylpyridin-4-amine) LD50 Dermal - Rabbit - 90 mg/kg(N,N-Dimethylpyridin-4-amine) LD50 Dermal - Guinea pig - 100 - 200 mg/kg(N,N-Dimethylpyridin-4-amine)

Skin corrosion/irritation Irritating to skin.(N,N-Dimethylpyridin-4-amine)

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Serious eye damage/eye irritation Irritating to eyes.(N,N-Dimethylpyridin-4-amine)

Respiratory or skin sensitisation Buehler Test(N,N-Dimethylpyridin-4-amine) Result: Does not cause skin sensitisation.

Germ cell mutagenicity No data available(N,N-Dimethylpyridin-4-amine)

Carcinogenicity

IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.

Reproductive toxicity No data available(N,N-Dimethylpyridin-4-amine)

Specific target organ toxicity - single exposure Inhalation - May cause respiratory irritation.(N,N-Dimethylpyridin-4-amine)

Specific target organ toxicity - repeated exposure No data available

Aspiration hazard No data available(N,N-Dimethylpyridin-4-amine)

Additional Information RTECS: US9230000 Weakness, Convulsions(N,N-Dimethylpyridin-4-amine)

SECTION 12: Ecological information

12.1 Toxicity No data available

12.2 Persistence and degradability No data available

12.3 Bioaccumulative potential No bioaccumulation is to be expected (log Pow <= 4).

12.4 Mobility in soil No data available(N,N-Dimethylpyridin-4-amine)

12.5 Results of PBT and vPvB assessment This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

12.6 Other adverse effects No data available

SECTION 13: Disposal considerations

13.1 Waste treatment methods

Product Dissolve or mix the material with a combustible solvent and burn in a chem scrubber. Offer surplus and non-recyclable solutions to a licensed disposal company.

Contaminated packaging Dispose of as unused product.

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SECTION 14: Transport information

14.1 UN number ADR/RID: 2811 IMDG: 2811 IATA: 2811

14.2 UN proper shipping name ADR/RID: TOXIC SOLID, ORGANIC, N.O.S. (N,N-Dimethylpyridin-4-amine) IMDG: TOXIC SOLID, ORGANIC, N.O.S. (N,N-Dimethylpyridin-4-amine) IATA: Toxic solid, organic, n.o.s. (N,N-Dimethylpyridin-4-amine)

14.3 Transport hazard class(es) ADR/RID: 6.1 IMDG: 6.1 IATA: 6.1

14.4 Packaging group ADR/RID: II IMDG: II IATA: II

14.5 Environmental hazards ADR/RID: no IMDG Marine pollutant: no IATA: no

14.6 Special precautions for user No data available

SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

15.2 Chemical safety assessment For this product a chemical safety assessment was not carried out

SECTION 16: Other information

Full text of H-Statements referred to under sections 2 and 3.

H301 Toxic if swallowed. H310 Fatal in contact with skin. H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation.

Further information Copyright 2016 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

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Sigma-Aldrich - 270989 Page 1 of 8

SIGMA-ALDRICH sigma-aldrich.com SAFETY DATA SHEET

according to Regulation (EC) No. 1907/2006 Version 6.0 Revision Date 30.03.2016

Print Date 10.11.2016 GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifiers Product name : Ethyl acetate

Product Number : 270989 Brand : Sigma-Aldrich Index-No. : 607-022-00-5 REACH No. : 01-2119475103-46-XXXX

CAS-No. : 141-78-6

1.2 Relevant identified uses of the substance or mixture and uses advised against

Identified uses : Laboratory chemicals, Manufacture of substances

1.3 Details of the supplier of the safety data sheet

Company : Sigma-Aldrich Chemical Pvt Limited Industrial Area, Anekal Taluka Plot No 12, 12 Bommasandra - Jigani Link Road 560100 BANGALORE INDIA

1.4 Emergency telephone number

Emergency Phone # : +91 98802 05043

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture

Classification according to Regulation (EC) No 1272/2008 Flammable liquids (Category 2), H225 Eye irritation (Category 2), H319 Specific target organ toxicity - single exposure (Category 3), Central nervous system, H336

For the full text of the H-Statements mentioned in this Section, see Section 16.

2.2 Label elements

Labelling according Regulation (EC) No 1272/2008 Pictogram

Signal word Danger Hazard statement(s) H225 Highly flammable liquid and vapour. H319 Causes serious eye irritation. H336 May cause drowsiness or dizziness. Precautionary statement(s) P210 Keep away from heat, hot surfaces, sparks, open flames and other

ignition sources. No smoking.

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P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

P370 + P378 In case of fire: Use dry powder or dry sand to extinguish. P403 + P235 Store in a well-ventilated place. Keep cool. Supplemental Hazard information (EU) EUH066 Repeated exposure may cause skin dryness or cracking.

2.3 Other hazards This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

SECTION 3: Composition/information on ingredients

3.1 Substances Formula : C4H8O2

Molecular weight : 88.11 g/mol CAS-No. : 141-78-6 EC-No. : 205-500-4 Index-No. : 607-022-00-5 Registration number : 01-2119475103-46-XXXX

Hazardous ingredients according to Regulation (EC) No 1272/2008

Component Classification Concentration

Ethyl acetate

CAS-No. EC-No. Index-No. Registration number

141-78-6 205-500-4 607-022-00-5 01-2119475103-46-XXXX

Flam. Liq. 2; Eye Irrit. 2; STOT SE 3; H225, H319, H336

<= 100 %

For the full text of the H-Statements mentioned in this Section, see Section 16.

SECTION 4: First aid measures

4.1 Description of first aid measures

General advice Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact Wash off with soap and plenty of water. Consult a physician.

In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

4.2 Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

4.3 Indication of any immediate medical attention and special treatment needed No data available

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SECTION 5: Firefighting measures

5.1 Extinguishing media

Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

5.2 Special hazards arising from the substance or mixture Carbon oxides

5.3 Advice for firefighters Wear self-contained breathing apparatus for firefighting if necessary.

5.4 Further information Use water spray to cool unopened containers.

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures Use personal protective equipment. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to form explosive concentrations. Vapours can accumulate in low areas. For personal protection see section 8.

6.2 Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

6.3 Methods and materials for containment and cleaning up Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations (see section 13).

6.4 Reference to other sections For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling Avoid contact with skin and eyes. Avoid inhalation of vapour or mist. Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic charge. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Storage class (TRGS 510): Flammable liquids

7.3 Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

8.1 Control parameters

Derived No Effect Level (DNEL)

Application Area Exposure routes

Health effect Value

Workers Inhalation Acute systemic effects 1468 mg/m3

Workers Inhalation Acute local effects 1468 mg/m3

Workers Skin contact Long-term systemic effects 63mg/kg BW/d

Workers Inhalation Long-term systemic effects 734 mg/m3

Workers Inhalation Long-term local effects 734 mg/m3

Consumers Inhalation Acute local effects, Acute systemic effects

734 mg/m3

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Consumers Skin contact Long-term systemic effects 37mg/kg BW/d

Consumers Inhalation Long-term systemic effects 367 mg/m3

Consumers Ingestion Long-term systemic effects 4.5mg/kg BW/d

Consumers Inhalation Long-term local effects 367 mg/m3

Predicted No Effect Concentration (PNEC)

Compartment Value

Soil 0.24 mg/kg

Marine water 0.026 mg/l

Fresh water 0.26 mg/l

Marine sediment 0.125 mg/kg

Fresh water sediment 1.25 mg/kg

8.2 Exposure controls

Appropriate engineering controls Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

Personal protective equipment

Eye/face protection Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Splash contact Material: butyl-rubber Minimum layer thickness: 0.3 mm Break through time: 113 min Material tested:Butoject® (KCL 897 / Aldrich Z677647, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail [email protected], test method: EN374 If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industria situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario. Body Protection Impervious clothing, Flame retardant antistatic protective clothing., The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use (US) or type ABEK (EN 14387) respirator cartridges as a backup to enginee protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Control of environmental exposure Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

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SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties

a) Appearance Form: clear, liquid Colour: colourless

b) Odour No data available

c) Odour Threshold No data available

d) pH No data available

e) Melting point/freezing point

Melting point/range: -84 °C

f) Initial boiling point and boiling range

76.5 - 77.5 °C

g) Flash point -3.0 °C - closed cup

h) Evaporation rate No data available

i) Flammability (solid, gas) No data available

j) Upper/lower flammability or explosive limits

Upper explosion limit: 11.5 %(V) Lower explosion limit: 2.2 %(V)

k) Vapour pressure 73.0 mmHg at 20.0 °C

l) Vapour density No data available

m) Relative density 0.90 g/cm3 at 20 °C

n) Water solubility soluble

o) Partition coefficient: n-octanol/water

log Pow: 0.73

p) Auto-ignition temperature

427.0 °C

q) Decomposition temperature

No data available

r) Viscosity No data available

s) Explosive properties No data available

t) Oxidizing properties No data available

9.2 Other safety information

Surface tension 24.0 mN/m at 20.0 °C

SECTION 10: Stability and reactivity

10.1 Reactivity No data available

10.2 Chemical stability Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions No data available

10.4 Conditions to avoid Heat, flames and sparks.

10.5 Incompatible materials Strong oxidizing agents

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10.6 Hazardous decomposition products Other decomposition products - No data available Hazardous decomposition products formed under fire conditions. - Carbon oxides In the event of fire: see section 5

SECTION 11: Toxicological information

11.1 Information on toxicological effects

Acute toxicity LD50 Oral - Rat - 5,620 mg/kg(Ethyl acetate) LC50 Inhalation - Mouse - 2 h - 45,000 mg/m3(Ethyl acetate) LD50 Dermal - Rabbit - > 18,000 mg/kg(Ethyl acetate)

Skin corrosion/irritation Skin - Rabbit(Ethyl acetate) Result: Mild skin irritation (OECD Test Guideline 404)

Serious eye damage/eye irritation Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)(Ethyl acetate)

Respiratory or skin sensitisation No data available(Ethyl acetate)

Germ cell mutagenicity No data available(Ethyl acetate)

Carcinogenicity This product is or contains a component that is not classifiable as to its classification.(Ethyl acetate) (Ethyl acetate)

IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.

Reproductive toxicity No data available(Ethyl acetate)

Specific target organ toxicity - single exposure May cause drowsiness or dizziness.(Ethyl acetate)

Specific target organ toxicity - repeated exposure No data available

Aspiration hazard No data available(Ethyl acetate)

Additional Information RTECS: AH5425000 Inhalation of high concentrations may cause:, Headache, Drowsiness, Dizziness, Vomiting, narcosis, anemia, Central nervous system depression(Ethyl acetate) Kidney - Irregularities - Based on Human Evidence(Ethyl acetate)

SECTION 12: Ecological information

12.1 Toxicity Toxicity to fish LC50 - Oncorhynchus mykiss (rainbow trout) - 350.00 - 600.00 mg/l - 96

h(Ethyl acetate) LC50 - Pimephales promelas (fathead minnow) - 220.00 - 250.00 mg/l - 96

h(Ethyl acetate)

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Toxicity to daphnia and other aquatic invertebrates

EC50 - Daphnia magna (Water flea) - 2,300.00 - 3,090.00 mg/l - 24 h(Ethyl acetate)

LC50 - Daphnia magna (Water flea) - 560 mg/l - 48 h(Ethyl acetate) Toxicity to algae EC50 - Algae - 4,300.00 mg/l - 24 h(Ethyl acetate) EC50 - SELENASTRUM - 1,800.00 - 3,200.00 mg/l - 72 h(Ethyl acetate)

12.2 Persistence and degradability Biodegradability Result: 79 % - Readily biodegradable

(OECD Test Guideline 301D)

12.3 Bioaccumulative potential Bioaccumulation - 3 d

(Ethyl acetate) Bioconcentration factor (BCF): 30

12.4 Mobility in soil No data available(Ethyl acetate)

12.5 Results of PBT and vPvB assessment This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

12.6 Other adverse effects No data available

SECTION 13: Disposal considerations

13.1 Waste treatment methods

Product Burn in a chemical incinerator equipped with an afterburner and scrubber b highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company.

Contaminated packaging Dispose of as unused product.

SECTION 14: Transport information

14.1 UN number ADR/RID: 1173 IMDG: 1173 IATA: 1173

14.2 UN proper shipping name ADR/RID: ETHYL ACETATE IMDG: ETHYL ACETATE IATA: Ethyl acetate

14.3 Transport hazard class(es) ADR/RID: 3 IMDG: 3 IATA: 3

14.4 Packaging group ADR/RID: II IMDG: II IATA: II

14.5 Environmental hazards ADR/RID: no IMDG Marine pollutant: no IATA: no

14.6 Special precautions for user No data available

SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

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15.2 Chemical safety assessment A Chemical Safety Assessment has been carried out for this substance.

SECTION 16: Other information

Full text of H-Statements referred to under sections 2 and 3.

EUH066 Repeated exposure may cause skin dryness or cracking. H225 Highly flammable liquid and vapour. H319 Causes serious eye irritation. H336 May cause drowsiness or dizziness.

Further information Copyright 2016 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

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SIGMA-ALDRICH sigma-aldrich.com SAFETY DATA SHEET

according to Regulation (EC) No. 1907/2006 Version 6.0 Revision Date 30.03.2016

Print Date 10.11.2016 GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifiers Product name : Ethylenediaminetetraacetic acid

Product Number : 03620 Brand : Sigma-Aldrich Index-No. : 607-429-00-8 REACH No. : A registration number is not available for this substance as the substance

or its uses are exempted from registration, the annual tonnage does not require a registration or the registration is envisaged for a later registration deadline.

CAS-No. : 60-00-4

1.2 Relevant identified uses of the substance or mixture and uses advised against

Identified uses : Laboratory chemicals, Manufacture of substances

1.3 Details of the supplier of the safety data sheet

Company : Sigma-Aldrich Chemical Pvt Limited Industrial Area, Anekal Taluka Plot No 12, 12 Bommasandra - Jigani Link Road 560100 BANGALORE INDIA

1.4 Emergency telephone number

Emergency Phone # : +91 98802 05043

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture

Classification according to Regulation (EC) No 1272/2008 Eye irritation (Category 2), H319

For the full text of the H-Statements mentioned in this Section, see Section 16.

2.2 Label elements

Labelling according Regulation (EC) No 1272/2008 Pictogram

Signal word Warning Hazard statement(s) H319 Causes serious eye irritation. Precautionary statement(s) P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove

contact lenses, if present and easy to do. Continue rinsing. Supplemental Hazard none

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Statements

2.3 Other hazards This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

SECTION 3: Composition/information on ingredients

3.1 Substances Formula : C10H16N2O8

Molecular weight : 292.24 g/mol CAS-No. : 60-00-4 EC-No. : 200-449-4 Index-No. : 607-429-00-8 Hazardous ingredients according to Regulation (EC) No 1272/2008

Component Classification Concentration

Edetic acid

CAS-No. EC-No. Index-No.

60-00-4 200-449-4 607-429-00-8

Eye Irrit. 2; H319 <= 100 %

For the full text of the H-Statements mentioned in this Section, see Section 16.

SECTION 4: First aid measures

4.1 Description of first aid measures

General advice Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact Wash off with soap and plenty of water. Consult a physician.

In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

4.2 Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

4.3 Indication of any immediate medical attention and special treatment needed No data available

SECTION 5: Firefighting measures

5.1 Extinguishing media

Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

5.2 Special hazards arising from the substance or mixture Carbon oxides, Nitrogen oxides (NOx)

5.3 Advice for firefighters Wear self-contained breathing apparatus for firefighting if necessary.

5.4 Further information No data available

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SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions Do not let product enter drains.

6.3 Methods and materials for containment and cleaning up Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.

6.4 Reference to other sections For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Non Combustible Solids

7.3 Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

8.1 Control parameters

8.2 Exposure controls

Appropriate engineering controls Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

Personal protective equipment

Eye/face protection Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Full contact Material: Nitrile rubber Minimum layer thickness: 0.11 mm Break through time: 480 min Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M) Splash contact Material: Nitrile rubber Minimum layer thickness: 0.11 mm Break through time: 480 min

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Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail [email protected], test method: EN374 If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industria situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario. Body Protection Impervious clothing, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection For nuisance exposures use type P95 (US) or type P1 (EU EN 143) particle r (US) or type ABEK-P2 (EU EN 143) respirator cartridges. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Control of environmental exposure Do not let product enter drains.

SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties

a) Appearance Form: powder Colour: white

b) Odour odourless

c) Odour Threshold No data available

d) pH 2.5 at 10 g/l at 23 °C

e) Melting point/freezing point

Melting point/range: 250 °C - dec.

f) Initial boiling point and boiling range

No data available

g) Flash point No data available

h) Evaporation rate No data available

i) Flammability (solid, gas) No data available

j) Upper/lower flammability or explosive limits

No data available

k) Vapour pressure No data available

l) Vapour density No data available

m) Relative density 1.46 g/cm3 at 20 °C

n) Water solubility 0.4 g/l at 20 °C

o) Partition coefficient: n-octanol/water

log Pow: 8.85 - 10.44 at 20 °C

p) Auto-ignition temperature

> 400 °C at 1,013 hPa

q) Decomposition temperature

No data available

r) Viscosity No data available

s) Explosive properties No data available

t) Oxidizing properties No data available

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9.2 Other safety information

Dissociation constant 8.85 - 10.44 at 20 °C

SECTION 10: Stability and reactivity

10.1 Reactivity No data available

10.2 Chemical stability Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions No data available

10.4 Conditions to avoid No data available

10.5 Incompatible materials Strong oxidizing agents

10.6 Hazardous decomposition products Hazardous decomposition products formed under fire conditions. - Carbon oxides, Nitrogen oxides (NOx) Other decomposition products - No data available In the event of fire: see section 5

SECTION 11: Toxicological information

11.1 Information on toxicological effects

Acute toxicity LD50 Oral - Rat - male and female - 4,500 mg/kg(Edetic acid)

Skin corrosion/irritation Skin - Rabbit(Edetic acid) Result: No skin irritation

Serious eye damage/eye irritation Eyes - Rabbit(Edetic acid) Result: Eye irritation

Respiratory or skin sensitisation Maximisation Test - Rabbit(Edetic acid) Result: Does not cause skin sensitisation.

Germ cell mutagenicity No data available(Edetic acid)

Carcinogenicity

IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.

Reproductive toxicity

No data available(Edetic acid)

Specific target organ toxicity - single exposure No data available(Edetic acid)

Specific target organ toxicity - repeated exposure No data available

Aspiration hazard No data available(Edetic acid)

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Additional Information RTECS: AH4025000 To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.(Edetic acid)

SECTION 12: Ecological information

12.1 Toxicity Toxicity to fish static test LC50 - Lepomis macrochirus (Bluegill sunfish) - 41 mg/l - 96

h(Edetic acid) Toxicity to daphnia and other aquatic invertebrates

static test EC50 - Daphnia magna (Water flea) - 625 mg/l - 48 h(Edetic acid)

12.2 Persistence and degradability

12.3 Bioaccumulative potential Bioaccumulation Lepomis macrochirus - 28 d

- 80 µg/l(Edetic acid) Bioconcentration factor (BCF): 1.8

12.4 Mobility in soil No data available(Edetic acid)

12.5 Results of PBT and vPvB assessment This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

12.6 Other adverse effects May be harmful to aquatic organisms due to the shift of the pH. Avoid release to the environment.

SECTION 13: Disposal considerations

13.1 Waste treatment methods

Product Offer surplus and non-recyclable solutions to a licensed disposal company. Dissolve or mix the material with a combustible solvent and burn in a chem scrubber.

Contaminated packaging Dispose of as unused product.

SECTION 14: Transport information

14.1 UN number ADR/RID: - IMDG: - IATA: -

14.2 UN proper shipping name ADR/RID: Not dangerous goods IMDG: Not dangerous goods IATA: Not dangerous goods

14.3 Transport hazard class(es) ADR/RID: - IMDG: - IATA: -

14.4 Packaging group ADR/RID: - IMDG: - IATA: -

14.5 Environmental hazards ADR/RID: no IMDG Marine pollutant: no IATA: no

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14.6 Special precautions for user No data available

SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

15.2 Chemical safety assessment For this product a chemical safety assessment was not carried out

SECTION 16: Other information

Full text of H-Statements referred to under sections 2 and 3.

H319 Causes serious eye irritation.

Further information Copyright 2016 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

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SIGMA-ALDRICH sigma-aldrich.com SAFETY DATA SHEET

according to Regulation (EC) No. 1907/2006 Version 6.0 Revision Date 30.03.2016

Print Date 10.11.2016 GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifiers Product name : 1,2-DICHLOROETHANE, ANHYDROUS, 99.8%

Product Number : 284505 Brand : Sigma-Aldrich Index-No. : 602-012-00-7 REACH No. : 01-2119484658-20-XXXX

CAS-No. : 107-06-2

1.2 Relevant identified uses of the substance or mixture and uses advised against

Identified uses : Laboratory chemicals, Manufacture of substances

1.3 Details of the supplier of the safety data sheet

Company : Sigma-Aldrich Chemical Pvt Limited Industrial Area, Anekal Taluka Plot No 12, 12 Bommasandra - Jigani Link Road 560100 BANGALORE INDIA

1.4 Emergency telephone number

Emergency Phone # : +91 98802 05043

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture

Classification according to Regulation (EC) No 1272/2008 Flammable liquids (Category 2), H225 Acute toxicity, Oral (Category 4), H302 Acute toxicity, Inhalation (Category 3), H331 Skin irritation (Category 2), H315 Eye irritation (Category 2), H319 Carcinogenicity (Category 1B), H350 Specific target organ toxicity - single exposure (Category 3), Respiratory system, H335

For the full text of the H-Statements mentioned in this Section, see Section 16.

2.2 Label elements

Labelling according Regulation (EC) No 1272/2008 Pictogram

Signal word Danger Hazard statement(s) H225 Highly flammable liquid and vapour. H302 Harmful if swallowed. H315 Causes skin irritation.

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H319 Causes serious eye irritation. H331 Toxic if inhaled. H335 May cause respiratory irritation. H350 May cause cancer. Precautionary statement(s) P201 Obtain special instructions before use. P210 Keep away from heat, hot surfaces, sparks, open flames and other

ignition sources. No smoking. P280 Wear protective gloves/ protective clothing/ eye protection/ face

protection. P308 + P313 IF exposed or concerned: Get medical advice/ attention. P370 + P378 In case of fire: Use dry powder or dry sand to extinguish. P403 + P235 Store in a well-ventilated place. Keep cool. Supplemental Hazard Statements

none

2.3 Other hazards This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

SECTION 3: Composition/information on ingredients

3.1 Substances Synonyms : Ethylene dichloride

Ethylene chloride

Formula : C2H4Cl2

Molecular weight : 98.96 g/mol CAS-No. : 107-06-2 EC-No. : 203-458-1 Index-No. : 602-012-00-7 Registration number : 01-2119484658-20-XXXX

Hazardous ingredients according to Regulation (EC) No 1272/2008

Component Classification Concentration

Ethylene dichloride Included in the Candidate List of Substances of Very High Concern (SVHC) according to Regulation (EC) No. 1907/2006 (REACH)

CAS-No. EC-No. Index-No. Registration number

107-06-2 203-458-1 602-012-00-7 01-2119484658-20-XXXX

Flam. Liq. 2; Acute Tox. 4; Acute Tox. 3; Skin Irrit. 2; Eye Irrit. 2; Carc. 1B; STOT SE 3; H225, H302, H331, H315, H319, H350, H335

<= 100 %

For the full text of the H-Statements mentioned in this Section, see Section 16.

SECTION 4: First aid measures

4.1 Description of first aid measures

General advice Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician.

In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

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If swallowed Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

4.2 Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

4.3 Indication of any immediate medical attention and special treatment needed No data available

SECTION 5: Firefighting measures

5.1 Extinguishing media

Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

5.2 Special hazards arising from the substance or mixture Carbon oxides, Hydrogen chloride gas

5.3 Advice for firefighters Wear self-contained breathing apparatus for firefighting if necessary.

5.4 Further information Use water spray to cool unopened containers.

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures Wear respiratory protection. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to form explosive concentrations. Vapours can accumulate in low areas. For personal protection see section 8.

6.2 Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

6.3 Methods and materials for containment and cleaning up Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations (see section 13).

6.4 Reference to other sections For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling Avoid exposure - obtain special instructions before use.Avoid contact with skin and eyes. Avoid inhalation of vapour or mist. Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic charge. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Storage class (TRGS 510): Flammable liquids

7.3 Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

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SECTION 8: Exposure controls/personal protection

8.1 Control parameters

8.2 Exposure controls

Appropriate engineering controls Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product.

Personal protective equipment

Eye/face protection Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Full contact Material: Fluorinated rubber Minimum layer thickness: 0.7 mm Break through time: 480 min Material tested:Vitoject® (KCL 890 / Aldrich Z677698, Size M) Splash contact Material: butyl-rubber Minimum layer thickness: 0.3 mm Break through time: 62 min Material tested:Butoject® (KCL 897 / Aldrich Z677647, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail [email protected], test method: EN374 If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industria situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario. Body Protection Complete suit protecting against chemicals, Flame retardant antistatic protective clothing., The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use (US) or type ABEK (EN 14387) respirator cartridges as a backup to enginee protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Control of environmental exposure Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties

a) Appearance Form: clear, liquid Colour: colourless

b) Odour No data available

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c) Odour Threshold No data available

d) pH No data available

e) Melting point/freezing point

Melting point/range: -35 °C - lit.

f) Initial boiling point and boiling range

83 °C - lit.

g) Flash point 13.0 °C - closed cup - Tested according to Annex V of Directive 67/548/EEC.

h) Evaporation rate No data available

i) Flammability (solid, gas) No data available

j) Upper/lower flammability or explosive limits

Upper explosion limit: 16.2 %(V) Lower explosion limit: 6.2 %(V)

k) Vapour pressure 33.3 hPa at 0 °C 86 hPa at 20 °C - Tested according to Annex V of Directive 67/548/EEC. 312 hPa at 50 °C

l) Vapour density No data available

m) Relative density 1.256 g/mL at 25 °C - lit.

n) Water solubility 8.69 g/l at 20 °C - Tested according to Annex V of Directive 67/548/EEC. - slightly soluble10.3 g/l at 56 °C

o) Partition coefficient: n-octanol/water

log Pow: 1.48 at 20 °C - Tested according to Annex V of Directive 67/548/EEC.

p) Auto-ignition temperature

413.0 °C

q) Decomposition temperature

No data available

r) Viscosity No data available

s) Explosive properties No data available

t) Oxidizing properties No data available

9.2 Other safety information

Surface tension 32.9 mN/m at 15 °C 32.2 mN/m at 20 °C 30.8 mN/m at 30 °C

SECTION 10: Stability and reactivity

10.1 Reactivity No data available

10.2 Chemical stability Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions No data available

10.4 Conditions to avoid Heat, flames and sparks.

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10.5 Incompatible materials Strong oxidizing agents

10.6 Hazardous decomposition products Hazardous decomposition products formed under fire conditions. - Carbon oxides, Hydrogen chloride gas Other decomposition products - No data available In the event of fire: see section 5

SECTION 11: Toxicological information

11.1 Information on toxicological effects

Acute toxicity LD50 Oral - Rat - 670.0 mg/kg(Ethylene dichloride) LC50 Inhalation - Rat - 4 h - 3.879 mg/l(Ethylene dichloride) LD50 Dermal - Rabbit - 2,800 mg/kg(Ethylene dichloride) Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and Taste):Eye:Lacrimation.

Skin corrosion/irritation Skin - Rabbit(Ethylene dichloride) Result: irritating - 72 h (Draize Test)

Serious eye damage/eye irritation Eyes - Rabbit(Ethylene dichloride) Result: Moderate eye irritation

Respiratory or skin sensitisation No data available(Ethylene dichloride)

Germ cell mutagenicity Laboratory experiments have shown mutagenic effects.(Ethylene dichloride) Ames test(Ethylene dichloride) S. typhimurium Result: positive

Carcinogenicity This product is or contains a component that has been reported to be proba EPA classification.(Ethylene dichloride) Possible human carcinogen(Ethylene dichloride)

IARC: 2B - Group 2B: Possibly carcinogenic to humans (Ethylene dichloride)

Reproductive toxicity

Specific target organ toxicity - single exposure May cause respiratory irritation.(Ethylene dichloride)

Specific target organ toxicity - repeated exposure No data available

Aspiration hazard No data available(Ethylene dichloride)

Additional Information RTECS: KI0525000 Acts as a simple asphyxiant by displacing air., anesthetic effects, Difficulty in breathing, Headache, Dizziness, Prolonged or repeated contact with skin may cause:, defatting, Dermatitis, Contact with eyes can cause:, Redness, Blurred vision, Provokes tears., Effects due to ingestion may include:, Gastrointestinal discomfort, Central nervous system depression, Paresthesia., Drowsiness, Convulsions, Conjunctivitis., Pulmonary edema. Effects may be delayed., Irregular breathing., Stomach/intestinal

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disorders, Nausea, Vomiting, Increased liver enzymes., Weakness, Heavy or prolonged skin exposure may result in the absorption of harmful amounts of material.(Ethylene dichloride) Pancreas. - (Ethylene dichloride)

SECTION 12: Ecological information

12.1 Toxicity Toxicity to fish LC50 - Oncorhynchus mykiss (rainbow trout) - 225.00 mg/l - 96 h(Ethylene

dichloride) NOEC - Cyprinodon variegatus (sheepshead minnow) - 130 mg/l - 96

h(Ethylene dichloride) Toxicity to daphnia and other aquatic invertebrates

EC50 - Daphnia magna (Water flea) - 540.00 mg/l - 24 h(Ethylene dichloride)

Immobilization EC50 - Daphnia magna (Water flea) - 160 mg/l - 48 h(Ethylene

dichloride)

12.2 Persistence and degradability Biodegradability Biotic/Aerobic - Exposure time 21 d(Ethylene dichloride)

Result: < 20 % - Not readily biodegradable. Remarks: Not applicable

12.3 Bioaccumulative potential Bioaccumulation Lepomis macrochirus (Bluegill) - 14 d

- 95.6 µg/l(Ethylene dichloride) Bioconcentration factor (BCF): 2

12.4 Mobility in soil No data available(Ethylene dichloride)

12.5 Results of PBT and vPvB assessment This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

12.6 Other adverse effects No data available

SECTION 13: Disposal considerations

13.1 Waste treatment methods

Product Burn in a chemical incinerator equipped with an afterburner and scrubber b highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company.

Contaminated packaging Dispose of as unused product.

SECTION 14: Transport information

14.1 UN number ADR/RID: 1184 IMDG: 1184 IATA: 1184

14.2 UN proper shipping name ADR/RID: ETHYLENE DICHLORIDE IMDG: ETHYLENE DICHLORIDE IATA: Ethylene dichloride

14.3 Transport hazard class(es) ADR/RID: 3 (6.1) IMDG: 3 (6.1) IATA: 3 (6.1)

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14.4 Packaging group ADR/RID: II IMDG: II IATA: II

14.5 Environmental hazards ADR/RID: no IMDG Marine pollutant: no IATA: no

14.6 Special precautions for user No data available

SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

Authorisations and/or restrictions on use 15.2 Chemical safety assessment

For this product a chemical safety assessment was not carried out

SECTION 16: Other information

Full text of H-Statements referred to under sections 2 and 3.

H225 Highly flammable liquid and vapour. H302 Harmful if swallowed. H315 Causes skin irritation. H319 Causes serious eye irritation. H331 Toxic if inhaled. H335 May cause respiratory irritation. H350 May cause cancer.

Further information Copyright 2016 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

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SIGMA-ALDRICH sigma-aldrich.com SAFETY DATA SHEET

according to Regulation (EC) No. 1907/2006 Version 6.0 Revision Date 30.03.2016

Print Date 10.11.2016 GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifiers Product name : Iron(III) chloride

Product Number : 451649 Brand : Aldrich REACH No. : A registration number is not available for this substance as the substance

or its uses are exempted from registration, the annual tonnage does not require a registration or the registration is envisaged for a later registration deadline.

CAS-No. : 7705-08-0

1.2 Relevant identified uses of the substance or mixture and uses advised against

Identified uses : Laboratory chemicals, Manufacture of substances

1.3 Details of the supplier of the safety data sheet

Company : Sigma-Aldrich Chemical Pvt Limited Industrial Area, Anekal Taluka Plot No 12, 12 Bommasandra - Jigani Link Road 560100 BANGALORE INDIA

1.4 Emergency telephone number

Emergency Phone # : +91 98802 05043

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture

Classification according to Regulation (EC) No 1272/2008 Corrosive to metals (Category 1), H290 Acute toxicity, Oral (Category 4), H302 Skin irritation (Category 2), H315 Serious eye damage (Category 1), H318

For the full text of the H-Statements mentioned in this Section, see Section 16.

2.2 Label elements

Labelling according Regulation (EC) No 1272/2008 Pictogram

Signal word Danger Hazard statement(s) H290 May be corrosive to metals. H302 Harmful if swallowed. H315 Causes skin irritation. H318 Causes serious eye damage.

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Precautionary statement(s) P280 Wear protective gloves/ eye protection/ face protection. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove

contact lenses, if present and easy to do. Continue rinsing. Supplemental Hazard Statements

none

2.3 Other hazards This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

SECTION 3: Composition/information on ingredients

3.1 Substances Synonyms : Ferric chloride

Formula : Cl<SB>3</>Fe Molecular weight : 162.20 g/mol CAS-No. : 7705-08-0 EC-No. : 231-729-4 Hazardous ingredients according to Regulation (EC) No 1272/2008

Component Classification Concentration

Iron trichloride

CAS-No. EC-No.

7705-08-0 231-729-4

Met. Corr. 1; Acute Tox. 4; Skin Irrit. 2; Eye Dam. 1; H290, H302, H315, H318

<= 100 %

For the full text of the H-Statements mentioned in this Section, see Section 16.

SECTION 4: First aid measures

4.1 Description of first aid measures

General advice Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact Wash off with soap and plenty of water. Consult a physician.

In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

4.2 Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

4.3 Indication of any immediate medical attention and special treatment needed No data available

SECTION 5: Firefighting measures

5.1 Extinguishing media

Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

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5.2 Special hazards arising from the substance or mixture Hydrogen chloride gas, Iron oxides

5.3 Advice for firefighters Wear self-contained breathing apparatus for firefighting if necessary.

5.4 Further information No data available

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures Wear respiratory protection. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

6.3 Methods and materials for containment and cleaning up Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.

6.4 Reference to other sections For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities Store under inert gas. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

Keep in a dry place. Storage class (TRGS 510): Non-combustible, corrosive hazardous materials

7.3 Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

8.1 Control parameters

8.2 Exposure controls

Appropriate engineering controls Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

Personal protective equipment

Eye/face protection Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

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Full contact Material: Nitrile rubber Minimum layer thickness: 0.11 mm Break through time: 480 min Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M) Splash contact Material: Nitrile rubber Minimum layer thickness: 0.11 mm Break through time: 480 min Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail [email protected], test method: EN374 If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industria situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario. Body Protection Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use (EN 143) respirator cartridges as a backup to engineering controls. If th full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Control of environmental exposure Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties

a) Appearance Form: powder

b) Odour No data available

c) Odour Threshold No data available

d) pH No data available

e) Melting point/freezing point

Melting point/range: 304 °C

f) Initial boiling point and boiling range

No data available

g) Flash point No data available

h) Evaporation rate No data available

i) Flammability (solid, gas) No data available

j) Upper/lower flammability or explosive limits

No data available

k) Vapour pressure < 1 mmHg at 20 °C 1 mmHg at 194 °C

l) Vapour density 5.60 - (Air = 1.0)

m) Relative density 2.800 g/cm3

n) Water solubility No data available

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o) Partition coefficient: n-octanol/water

No data available

p) Auto-ignition temperature

No data available

q) Decomposition temperature

No data available

r) Viscosity No data available

s) Explosive properties No data available

t) Oxidizing properties No data available

9.2 Other safety information

Relative vapour density 5.60 - (Air = 1.0)

SECTION 10: Stability and reactivity

10.1 Reactivity No data available

10.2 Chemical stability Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions No data available

10.4 Conditions to avoid No data available

10.5 Incompatible materials Strong oxidizing agents, Potassium, Alkali metals, Bases, Exothermic in contact with water, Forms shock-sensitive mixtures with certain other materials.

10.6 Hazardous decomposition products Hazardous decomposition products formed under fire conditions. - Hydrogen chloride gas, Iron oxides Other decomposition products - No data available In the event of fire: see section 5

SECTION 11: Toxicological information

11.1 Information on toxicological effects

Acute toxicity LD50 Oral - Mouse - 1,300 mg/kg(Iron trichloride) LD50 Dermal - Rabbit - > 2,000 mg/kg(Iron trichloride) (OECD Test Guideline 402)

Skin corrosion/irritation Skin - Rabbit(Iron trichloride) Result: Irritating to skin.

Serious eye damage/eye irritation Eyes - Rabbit(Iron trichloride) Result: Severe eye irritation

Respiratory or skin sensitisation No data available(Iron trichloride)

Germ cell mutagenicity No data available(Iron trichloride)

Carcinogenicity

IARC: No component of this product present at levels greater than or equal to 0.1% is identified as

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probable, possible or confirmed human carcinogen by IARC.

Reproductive toxicity No data available(Iron trichloride)

Specific target organ toxicity - single exposure No data available(Iron trichloride)

Specific target organ toxicity - repeated exposure No data available

Aspiration hazard No data available(Iron trichloride)

Additional Information RTECS: LJ9100000 spasm, inflammation and edema of the larynx, spasm, inflammation and edema of the bronchi, pneumonitis, pulmonary edema, Overdose of iron compounds may have a corrosive effect on the gastrointest stricture formation. Several hours may elapse before symptoms that can in hematemesis occur. After apparent recovery a person may experience metabo Further complications may develop leading to acute liver necrosis that ca, To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.(Iron trichloride)

SECTION 12: Ecological information

12.1 Toxicity Toxicity to fish LC50 - Pimephales promelas (fathead minnow) - 21.84 mg/l - 96 h(Iron

trichloride) Toxicity to daphnia and other aquatic invertebrates

EC50 - Daphnia magna (Water flea) - 9.6 mg/l - 48 h(Iron trichloride)

12.2 Persistence and degradability No data available

12.3 Bioaccumulative potential No data available

12.4 Mobility in soil No data available(Iron trichloride)

12.5 Results of PBT and vPvB assessment This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

12.6 Other adverse effects Toxic to aquatic life. No data available

SECTION 13: Disposal considerations

13.1 Waste treatment methods

Product Offer surplus and non-recyclable solutions to a licensed disposal company. Dissolve or mix the material with a combustible solvent and burn in a chem scrubber.

Contaminated packaging Dispose of as unused product.

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SECTION 14: Transport information

14.1 UN number ADR/RID: 1773 IMDG: 1773 IATA: 1773

14.2 UN proper shipping name ADR/RID: FERRIC CHLORIDE, ANHYDROUS IMDG: FERRIC CHLORIDE, ANHYDROUS IATA: Ferric chloride, anhydrous

14.3 Transport hazard class(es) ADR/RID: 8 IMDG: 8 IATA: 8

14.4 Packaging group ADR/RID: III IMDG: III IATA: III

14.5 Environmental hazards ADR/RID: no IMDG Marine pollutant: no IATA: no

14.6 Special precautions for user No data available

SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

15.2 Chemical safety assessment For this product a chemical safety assessment was not carried out

SECTION 16: Other information

Full text of H-Statements referred to under sections 2 and 3.

H290 May be corrosive to metals. H302 Harmful if swallowed. H315 Causes skin irritation. H318 Causes serious eye damage.

Further information Copyright 2016 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

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SIGMA-ALDRICH sigma-aldrich.com SAFETY DATA SHEET

according to Regulation (EC) No. 1907/2006 Version 6.0 Revision Date 30.03.2016

Print Date 10.11.2016 GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifiers Product name : Formaldehyde solution, 36.5-38%

Product Number : F8775 Brand : Sigma Index-No. : 605-001-00-5 REACH No. : A registration number is not available for this substance as the substance

or its uses are exempted from registration, the annual tonnage does not require a registration or the registration is envisaged for a later registration deadline.

CAS-No. : 50-00-0

1.2 Relevant identified uses of the substance or mixture and uses advised against

Identified uses : Laboratory chemicals, Manufacture of substances

1.3 Details of the supplier of the safety data sheet

Company : Sigma-Aldrich Chemical Pvt Limited Industrial Area, Anekal Taluka Plot No 12, 12 Bommasandra - Jigani Link Road 560100 BANGALORE INDIA

1.4 Emergency telephone number

Emergency Phone # : +91 98802 05043

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture

Classification according to Regulation (EC) No 1272/2008 Acute toxicity, Oral (Category 3), H301 Acute toxicity, Inhalation (Category 3), H331 Acute toxicity, Dermal (Category 3), H311 Skin corrosion (Category 1B), H314 Skin sensitisation (Category 1), H317 Germ cell mutagenicity (Category 2), H341 Carcinogenicity (Category 1B), H350 Specific target organ toxicity - single exposure (Category 1), H370 Specific target organ toxicity - single exposure (Category 3), Respiratory system, H335

For the full text of the H-Statements mentioned in this Section, see Section 16.

2.2 Label elements

Labelling according Regulation (EC) No 1272/2008 Pictogram

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Signal word Danger Hazard statement(s) H301 + H311 + H331 Toxic if swallowed, in contact with skin or if inhaled H314 Causes severe skin burns and eye damage. H317 May cause an allergic skin reaction. H335 May cause respiratory irritation. H341 Suspected of causing genetic defects. H350 May cause cancer. H370 Causes damage to organs. Precautionary statement(s) P201 Obtain special instructions before use. P260 Do not breathe dust/ fume/ gas/ mist/ vapours/ spray. P280 Wear protective gloves/ protective clothing/ eye protection/ face

protection. P301 + P310 + P330 IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse

mouth. P303 + P361 + P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing.

Rinse skin with water/shower. P304 + P340 + P310 IF INHALED: Remove person to fresh air and keep comfortable for

breathing. Immediately call a POISON CENTER/doctor. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove

contact lenses, if present and easy to do. Continue rinsing. P308 + P311 IF exposed or concerned: Call a POISON CENTER/doctor. P403 + P233 Store in a well-ventilated place. Keep container tightly closed. Supplemental Hazard Statements

none

Restricted to professional users.

2.3 Other hazards This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

SECTION 3: Composition/information on ingredients

3.2 Mixtures Synonyms : Formalin

Formula : CH2O Hazardous ingredients according to Regulation (EC) No 1272/2008

Component Classification Concentration

Formaldehyde

CAS-No. EC-No. Index-No. Registration number

50-00-0 200-001-8 605-001-00-5 01-2119488953-20-0169

Acute Tox. 3; Skin Corr. 1B; Skin Sens. 1; Muta. 2; Carc. 1B; H301, H331, H311, H314, H317, H341, H350 Concentration limits: >= 25 %: Skin Corr. 1B, H314; 5 - < 25 %: Skin Irrit. 2, H315; 5 - < 25 %: Eye Irrit. 2, H319; >= 5 %: STOT SE 3, H335; >= 0.2 %: Skin Sens. 1, H317;

>= 30 - < 50 %

Methanol

CAS-No. EC-No. Index-No. Registration number

67-56-1 200-659-6 603-001-00-X 01-2119433307-44-XXXX

Flam. Liq. 2; Acute Tox. 3; STOT SE 1; H225, H301, H331, H311, H370 Concentration limits:

>= 10 - < 20 %

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>= 10 %: STOT SE 1, H370; 3 - < 10 %: STOT SE 2, H371;

For the full text of the H-Statements mentioned in this Section, see Section 16.

SECTION 4: First aid measures

4.1 Description of first aid measures

General advice Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact Take off contaminated clothing and shoes immediately. Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician.

In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

4.2 Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

4.3 Indication of any immediate medical attention and special treatment needed No data available

SECTION 5: Firefighting measures

5.1 Extinguishing media

Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

5.2 Special hazards arising from the substance or mixture Carbon oxides

5.3 Advice for firefighters Wear self-contained breathing apparatus for firefighting if necessary.

5.4 Further information Use water spray to cool unopened containers.

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures Wear respiratory protection. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to form explosive concentrations. Vapours can accumulate in low areas. For personal protection see section 8.

6.2 Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

6.3 Methods and materials for containment and cleaning up Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations (see section 13). Keep in suitable, closed containers for disposal.

6.4 Reference to other sections For disposal see section 13.

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SECTION 7: Handling and storage

7.1 Precautions for safe handling Avoid exposure - obtain special instructions before use.Avoid contact with skin and eyes. Avoid inhalation of vapour or mist. Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic charge. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Storage class (TRGS 510): Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

7.3 Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

8.1 Control parameters

8.2 Exposure controls

Appropriate engineering controls Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product.

Personal protective equipment

Eye/face protection Tightly fitting safety goggles. Faceshield (8-inch minimum). Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Full contact Material: Nitrile rubber Minimum layer thickness: 0.4 mm Break through time: 480 min Material tested:Camatril® (KCL 730 / Aldrich Z677442, Size M) Splash contact Material: Nitrile rubber Minimum layer thickness: 0.2 mm Break through time: 60 min Material tested:Dermatril® P (KCL 743 / Aldrich Z677388, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail [email protected], test method: EN374 If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industria situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario.

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Body Protection Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use (US) or type ABEK (EN 14387) respirator cartridges as a backup to enginee protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Control of environmental exposure Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties

a) Appearance Form: liquid Colour: clear

b) Odour No data available

c) Odour Threshold No data available

d) pH No data available

e) Melting point/freezing point

No data available

f) Initial boiling point and boiling range

No data available

g) Flash point 64 °C - closed cup

h) Evaporation rate No data available

i) Flammability (solid, gas) No data available

j) Upper/lower flammability or explosive limits

Upper explosion limit: 73 %(V) Lower explosion limit: 7 %(V)

k) Vapour pressure 69 hPa at 37 °C

l) Vapour density 1.04 - (Air = 1.0)

m) Relative density 1.016 g/cm3 at 20 °C

n) Water solubility No data available

o) Partition coefficient: n-octanol/water

No data available

p) Auto-ignition temperature

No data available

q) Decomposition temperature

No data available

r) Viscosity No data available

s) Explosive properties No data available

t) Oxidizing properties No data available

9.2 Other safety information

Relative vapour density 1.04 - (Air = 1.0)

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SECTION 10: Stability and reactivity

10.1 Reactivity No data available

10.2 Chemical stability Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions No data available

10.4 Conditions to avoid Heat, flames and sparks.

10.5 Incompatible materials No data available

10.6 Hazardous decomposition products Hazardous decomposition products formed under fire conditions. - Carbon oxides In the event of fire: see section 5

SECTION 11: Toxicological information

11.1 Information on toxicological effects

Acute toxicity Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)

Skin corrosion/irritation Skin - Rabbit Result: Corrosive after 3 minutes to 1 hour of exposure - 20 h (OECD Test Guideline 404)

Serious eye damage/eye irritation Eyes - Rabbit Result: Corrosive - 7 d (OECD Test Guideline 405)

Respiratory or skin sensitisation Maximisation Test - Guinea pig Result: Causes sensitisation. May cause allergic skin reaction. (OECD Test Guideline 406)

Germ cell mutagenicity No data available

Carcinogenicity

IARC: 1 - Group 1: Carcinogenic to humans (Formaldehyde)

Reproductive toxicity No data available

Specific target organ toxicity - single exposure No data available

Specific target organ toxicity - repeated exposure No data available

Aspiration hazard No data available

Additional Information RTECS: LP8925000

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SECTION 12: Ecological information

12.1 Toxicity No data available

12.2 Persistence and degradability No data available

12.3 Bioaccumulative potential No data available

12.4 Mobility in soil No data available

12.5 Results of PBT and vPvB assessment This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

12.6 Other adverse effects Harmful to aquatic life.

SECTION 13: Disposal considerations

13.1 Waste treatment methods

Product This combustible material may be burned in a chemical incinerator equipped with an afterburner and scrubber. Offer surplus and non-recyclable solutions to a licensed disposal company.

Contaminated packaging Dispose of as unused product.

SECTION 14: Transport information

14.1 UN number ADR/RID: 2209 IMDG: 2209 IATA: 2209

14.2 UN proper shipping name ADR/RID: FORMALDEHYDE SOLUTION IMDG: FORMALDEHYDE SOLUTION IATA: Formaldehyde solution

14.3 Transport hazard class(es) ADR/RID: 8 IMDG: 8 IATA: 8

14.4 Packaging group ADR/RID: III IMDG: III IATA: III

14.5 Environmental hazards ADR/RID: no IMDG Marine pollutant: no IATA: no

14.6 Special precautions for user No data available

SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

15.2 Chemical safety assessment For this product a chemical safety assessment was not carried out

SECTION 16: Other information

Full text of H-Statements referred to under sections 2 and 3.

H225 Highly flammable liquid and vapour. H301 Toxic if swallowed.

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H301 + H311 + H331

Toxic if swallowed, in contact with skin or if inhaled

H311 Toxic in contact with skin. H314 Causes severe skin burns and eye damage. H315 Causes skin irritation. H317 May cause an allergic skin reaction. H319 Causes serious eye irritation. H331 Toxic if inhaled. H335 May cause respiratory irritation. H341 Suspected of causing genetic defects. H350 May cause cancer. H370 Causes damage to organs. H371 May cause damage to organs.

Further information Copyright 2016 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

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Sigma-Aldrich - 240745 Page 1 of 7

SIGMA-ALDRICH sigma-aldrich.com SAFETY DATA SHEET

according to Regulation (EC) No. 1907/2006 Version 6.0 Revision Date 30.03.2016

Print Date 10.11.2016 GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifiers Product name : Fumaric acid

Product Number : 240745 Brand : Sigma-Aldrich Index-No. : 607-146-00-X REACH No. : A registration number is not available for this substance as the substance

or its uses are exempted from registration, the annual tonnage does not require a registration or the registration is envisaged for a later registration deadline.

CAS-No. : 110-17-8

1.2 Relevant identified uses of the substance or mixture and uses advised against

Identified uses : Laboratory chemicals, Manufacture of substances

1.3 Details of the supplier of the safety data sheet

Company : Sigma-Aldrich Chemical Pvt Limited Industrial Area, Anekal Taluka Plot No 12, 12 Bommasandra - Jigani Link Road 560100 BANGALORE INDIA

1.4 Emergency telephone number

Emergency Phone # : +91 98802 05043

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture

Classification according to Regulation (EC) No 1272/2008 Eye irritation (Category 2), H319

For the full text of the H-Statements mentioned in this Section, see Section 16.

2.2 Label elements

Labelling according Regulation (EC) No 1272/2008 Pictogram

Signal word Warning Hazard statement(s) H319 Causes serious eye irritation. Precautionary statement(s) P280 Wear eye protection/ face protection. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove

contact lenses, if present and easy to do. Continue rinsing.

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P337 + P313 If eye irritation persists: Get medical advice/ attention. Supplemental Hazard Statements

none

2.3 Other hazards This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

SECTION 3: Composition/information on ingredients

3.1 Substances Formula : C4H4O4

Molecular weight : 116.07 g/mol CAS-No. : 110-17-8 EC-No. : 203-743-0 Index-No. : 607-146-00-X Hazardous ingredients according to Regulation (EC) No 1272/2008

Component Classification Concentration

Fumaric acid

CAS-No. EC-No. Index-No.

110-17-8 203-743-0 607-146-00-X

Eye Irrit. 2; H319 <= 100 %

For the full text of the H-Statements mentioned in this Section, see Section 16.

SECTION 4: First aid measures

4.1 Description of first aid measures

General advice Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact Wash off with soap and plenty of water. Consult a physician.

In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

4.2 Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

4.3 Indication of any immediate medical attention and special treatment needed No data available

SECTION 5: Firefighting measures

5.1 Extinguishing media

Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

5.2 Special hazards arising from the substance or mixture Carbon oxides

5.3 Advice for firefighters Wear self-contained breathing apparatus for firefighting if necessary.

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5.4 Further information No data available

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions Do not let product enter drains.

6.3 Methods and materials for containment and cleaning up Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.

6.4 Reference to other sections For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Non Combustible Solids

7.3 Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

8.1 Control parameters

8.2 Exposure controls

Appropriate engineering controls Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

Personal protective equipment

Eye/face protection Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Full contact Material: Nitrile rubber Minimum layer thickness: 0.11 mm Break through time: 480 min Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M) Splash contact Material: Nitrile rubber

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Minimum layer thickness: 0.11 mm Break through time: 480 min Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail [email protected], test method: EN374 If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industria situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario. Body Protection Impervious clothing, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection For nuisance exposures use type P95 (US) or type P1 (EU EN 143) particle r (US) or type ABEK-P2 (EU EN 143) respirator cartridges. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Control of environmental exposure Do not let product enter drains.

SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties

a) Appearance Form: solid

b) Odour No data available

c) Odour Threshold No data available

d) pH 2.1 at 4.9 g/l at 20 °C

e) Melting point/freezing point

Melting point/range: 287 °C - DIN 53181

f) Initial boiling point and boiling range

No data available

g) Flash point 230 °C - closed cup - DIN 51755 Part 1

h) Evaporation rate No data available

i) Flammability (solid, gas) No data available

j) Upper/lower flammability or explosive limits

Upper explosion limit: 40 %(V) Lower explosion limit: 3 %(V)

k) Vapour pressure 2.2 hPa at 165 °C

l) Vapour density No data available

m) Relative density 1.635 g/cm3 at 20 °C

n) Water solubility 7 g/l at 25 °C - soluble

o) Partition coefficient: n-octanol/water

log Pow: 0.46 at 20 °C

p) Auto-ignition temperature

ca.399 °C at 1013.0 hPa

q) Decomposition temperature

No data available

r) Viscosity No data available

s) Explosive properties No data available

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t) Oxidizing properties No data available

9.2 Other safety information No data available

SECTION 10: Stability and reactivity

10.1 Reactivity No data available

10.2 Chemical stability Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions No data available

10.4 Conditions to avoid No data available

10.5 Incompatible materials Oxidizing agents, Amines, Strong bases

10.6 Hazardous decomposition products Hazardous decomposition products formed under fire conditions. - Carbon oxides Other decomposition products - No data available In the event of fire: see section 5

SECTION 11: Toxicological information

11.1 Information on toxicological effects

Acute toxicity LD50 Oral - Rat - female - 9,300 mg/kg(Fumaric acid) (OECD Test Guideline 401) LD50 Dermal - Rabbit - female - 20,000 mg/kg(Fumaric acid) (OECD Test Guideline 402) LD50 Intraperitoneal - Mouse - 100 mg/kg(Fumaric acid)

Skin corrosion/irritation Skin - Rabbit(Fumaric acid) Result: Mild skin irritation - 4 h (OECD Test Guideline 404)

Serious eye damage/eye irritation Eyes - Rabbit(Fumaric acid) Result: Irritating to eyes. (OECD Test Guideline 405)

Respiratory or skin sensitisation Maximisation Test - Guinea pig(Fumaric acid) Result: Does not cause skin sensitisation. (OECD Test Guideline 406)

Germ cell mutagenicity Mouse(Fumaric acid) lymphocyte Result: negative

Carcinogenicity

IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.

Reproductive toxicity

No data available(Fumaric acid)

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Specific target organ toxicity - single exposure No data available(Fumaric acid)

Specific target organ toxicity - repeated exposure No data available

Aspiration hazard No data available(Fumaric acid)

Additional Information

Repeated dose toxicity - Rat - male - Oral - No observed adverse effect level - 600 mg/kg(Fumaric acid) RTECS: LS9625000 Gastrointestinal disturbance, To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.(Fumaric acid)

SECTION 12: Ecological information

12.1 Toxicity Toxicity to fish semi-static test LC50 - Danio rerio (zebra fish) - > 100 mg/l - 96 h(Fumaric

acid) (OECD Test Guideline 203)

Toxicity to daphnia and other aquatic invertebrates

Immobilization EC50 - Daphnia magna (Water flea) - 212 mg/l - 48 h(Fumaric acid) (OECD Test Guideline 202)

Toxicity to algae Growth inhibition EC50 - Pseudokirchneriella subcapitata - > 100 mg/l - 72

h(Fumaric acid) (OECD Test Guideline 201)

Toxicity to bacteria Respiration inhibition EC50 - activated sludge - > 300 mg/l - 3 h(Fumaric acid)

(OECD Test Guideline 209)

12.2 Persistence and degradability Biodegradability aerobic - Exposure time 28 d(Fumaric acid)

Result: 67.5 % - Readily biodegradable (OECD Test Guideline 301B)

12.3 Bioaccumulative potential No data available

12.4 Mobility in soil No data available(Fumaric acid)

12.5 Results of PBT and vPvB assessment This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

12.6 Other adverse effects No data available

SECTION 13: Disposal considerations

13.1 Waste treatment methods

Product Offer surplus and non-recyclable solutions to a licensed disposal company. Dissolve or mix the material with a combustible solvent and burn in a chem scrubber.

Contaminated packaging Dispose of as unused product.

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SECTION 14: Transport information

14.1 UN number ADR/RID: - IMDG: - IATA: -

14.2 UN proper shipping name ADR/RID: Not dangerous goods IMDG: Not dangerous goods IATA: Not dangerous goods

14.3 Transport hazard class(es) ADR/RID: - IMDG: - IATA: -

14.4 Packaging group ADR/RID: - IMDG: - IATA: -

14.5 Environmental hazards ADR/RID: no IMDG Marine pollutant: no IATA: no

14.6 Special precautions for user No data available

SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

15.2 Chemical safety assessment For this product a chemical safety assessment was not carried out

SECTION 16: Other information

Full text of H-Statements referred to under sections 2 and 3.

H319 Causes serious eye irritation.

Further information Copyright 2016 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

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Sigma - H0883 Page 1 of 8

SIGMA-ALDRICH sigma-aldrich.com SAFETY DATA SHEET

according to Regulation (EC) No. 1907/2006 Version 6.0 Revision Date 03.04.2016

Print Date 10.11.2016 GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifiers Product name : Hydrazine monohydrate

Product Number : H0883 Brand : Sigma REACH No. : A registration number is not available for this substance as the substance

or its uses are exempted from registration, the annual tonnage does not require a registration or the registration is envisaged for a later registration deadline.

1.2 Relevant identified uses of the substance or mixture and uses advised against

Identified uses : Laboratory chemicals, Manufacture of substances

1.3 Details of the supplier of the safety data sheet

Company : Sigma-Aldrich Chemical Pvt Limited Industrial Area, Anekal Taluka Plot No 12, 12 Bommasandra - Jigani Link Road 560100 BANGALORE INDIA

1.4 Emergency telephone number

Emergency Phone # : +91 98802 05043

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture

Classification according to Regulation (EC) No 1272/2008 Acute toxicity, Oral (Category 3), H301 Acute toxicity, Inhalation (Category 2), H330 Acute toxicity, Dermal (Category 4), H312 Skin corrosion (Category 1B), H314 Skin sensitisation (Category 1), H317 Carcinogenicity (Category 1B), H350 Acute aquatic toxicity (Category 1), H400 Chronic aquatic toxicity (Category 1), H410

For the full text of the H-Statements mentioned in this Section, see Section 16.

2.2 Label elements

Labelling according Regulation (EC) No 1272/2008 Pictogram

Signal word Danger Hazard statement(s) H301 Toxic if swallowed.

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H312 Harmful in contact with skin. H314 Causes severe skin burns and eye damage. H317 May cause an allergic skin reaction. H330 Fatal if inhaled. H350 May cause cancer. H410 Very toxic to aquatic life with long lasting effects. Precautionary statement(s) P201 Obtain special instructions before use. P260 Do not breathe dust/ fume/ gas/ mist/ vapours/ spray. P273 Avoid release to the environment. P280 Wear protective gloves/ protective clothing/ eye protection/ face

protection. P304 + P340 + P310 IF INHALED: Remove person to fresh air and keep comfortable for

breathing. Immediately call a POISON CENTER/doctor. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove

contact lenses, if present and easy to do. Continue rinsing. Supplemental Hazard Statements

none

Restricted to professional users.

2.3 Other hazards This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

SECTION 3: Composition/information on ingredients

3.2 Mixtures Synonyms : Hydrazinium hydroxide

Molecular weight : 50.06 g/mol Hazardous ingredients according to Regulation (EC) No 1272/2008

Component Classification Concentration

Hydrazine Included in the Candidate List of Substances of Very High Concern (SVHC) according to Regulation (EC) No. 1907/2006 (REACH)

CAS-No. EC-No. Index-No.

302-01-2 206-114-9 007-008-00-3

Flam. Liq. 3; Acute Tox. 3; Acute Tox. 2; Acute Tox. 3; Skin Corr. 1B; Skin Sens. 1; Carc. 1B; Aquatic Acute 1; Aquatic Chronic 1; H226, H301, H330, H311, H314, H317, H350, H400, H410 Concentration limits: >= 10 %: Skin Corr. 1B, H314; 3 - < 10 %: Skin Irrit. 2, H315; 3 - < 10 %: Eye Irrit. 2, H319;

M-Factor - Aquatic Acute: 10 -

Aquatic Chronic: 10

>= 70 - < 90 %

For the full text of the H-Statements mentioned in this Section, see Section 16.

SECTION 4: First aid measures

4.1 Description of first aid measures

General advice Consult a physician. Show this safety data sheet to the doctor in attendance.

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If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact Take off contaminated clothing and shoes immediately. Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician.

In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

4.2 Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

4.3 Indication of any immediate medical attention and special treatment needed No data available

SECTION 5: Firefighting measures

5.1 Extinguishing media

Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

5.2 Special hazards arising from the substance or mixture Nitrogen oxides (NOx)

5.3 Advice for firefighters Wear self-contained breathing apparatus for firefighting if necessary.

5.4 Further information Use water spray to cool unopened containers.

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures Wear respiratory protection. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to form explosive concentrations. Vapours can accumulate in low areas. For personal protection see section 8.

6.2 Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

6.3 Methods and materials for containment and cleaning up Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations (see section 13). Keep in suitable, closed containers for disposal.

6.4 Reference to other sections For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling Avoid exposure - obtain special instructions before use.Avoid contact with skin and eyes. Avoid inhalation of vapour or mist. Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic charge. For precautions see section 2.2.

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7.2 Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Storage class (TRGS 510): Combustible liquids, toxic

7.3 Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

8.1 Control parameters

8.2 Exposure controls

Appropriate engineering controls Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product.

Personal protective equipment

Eye/face protection Tightly fitting safety goggles. Faceshield (8-inch minimum). Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Full contact Material: butyl-rubber Minimum layer thickness: 0.3 mm Break through time: 480 min Material tested:Butoject® (KCL 897 / Aldrich Z677647, Size M) Splash contact Material: Nitrile rubber Minimum layer thickness: 0.11 mm Break through time: 30 min Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail [email protected], test method: EN374 If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industria situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario. Body Protection Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use (US) or type ABEK (EN 14387) respirator cartridges as a backup to enginee protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Control of environmental exposure Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

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SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties

a) Appearance Form: liquid, clear Colour: colourless

b) Odour No data available

c) Odour Threshold No data available

d) pH No data available

e) Melting point/freezing point

-51.7 °C

f) Initial boiling point and boiling range

120.1 °C at 1,013 hPa

g) Flash point 74 °C - closed cup

h) Evaporation rate No data available

i) Flammability (solid, gas) No data available

j) Upper/lower flammability or explosive limits

No data available

k) Vapour pressure 5 mmHg at 25 °C

l) Vapour density 1.73 - (Air = 1.0)

m) Relative density 1.032 g/cm3

n) Water solubility No data available

o) Partition coefficient: n-octanol/water

No data available

p) Auto-ignition temperature

No data available

q) Decomposition temperature

No data available

r) Viscosity No data available

s) Explosive properties No data available

t) Oxidizing properties No data available

9.2 Other safety information

Relative vapour density 1.73 - (Air = 1.0)

SECTION 10: Stability and reactivity

10.1 Reactivity No data available

10.2 Chemical stability Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions No data available

10.4 Conditions to avoid Heat, flames and sparks.

10.5 Incompatible materials Oxidizing agents, Oxygen, Copper, Zinc, Organic materials

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10.6 Hazardous decomposition products Other decomposition products - No data available Hazardous decomposition products formed under fire conditions. - Nitrogen oxides (NOx) In the event of fire: see section 5

SECTION 11: Toxicological information

11.1 Information on toxicological effects

Acute toxicity No data available

Skin corrosion/irritation No data available

Serious eye damage/eye irritation No data available

Respiratory or skin sensitisation No data available

Germ cell mutagenicity No data available

Carcinogenicity

IARC: 2B - Group 2B: Possibly carcinogenic to humans (Hydrazine)

Reproductive toxicity No data available

Specific target organ toxicity - single exposure No data available

Specific target organ toxicity - repeated exposure No data available

Aspiration hazard No data available

Additional Information RTECS: Not available CNS stimulation., Cyanosis, Salivation, Seizures., Diarrhoea, Fever, Confusion., Hypoglycemia, Anorexia., Convulsions, Coma.

SECTION 12: Ecological information

12.1 Toxicity No data available

12.2 Persistence and degradability No data available

12.3 Bioaccumulative potential No data available

12.4 Mobility in soil No data available

12.5 Results of PBT and vPvB assessment This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

12.6 Other adverse effects Very toxic to aquatic life with long lasting effects.

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SECTION 13: Disposal considerations

13.1 Waste treatment methods

Product This combustible material may be burned in a chemical incinerator equipped with an afterburner and scrubber. Offer surplus and non-recyclable solutions to a licensed disposal company.

Contaminated packaging Dispose of as unused product.

SECTION 14: Transport information

14.1 UN number ADR/RID: 2030 IMDG: 2030 IATA: 2030

14.2 UN proper shipping name ADR/RID: HYDRAZINE, AQUEOUS SOLUTION IMDG: HYDRAZINE, AQUEOUS SOLUTION IATA: Hydrazine, aqueous solution Passenger Aircraft: Not permitted for transport

14.3 Transport hazard class(es) ADR/RID: 8 (6.1) IMDG: 8 (6.1) IATA: 8 (6.1)

14.4 Packaging group ADR/RID: II IMDG: II IATA: II

14.5 Environmental hazards ADR/RID: no IMDG Marine pollutant: no IATA: no

14.6 Special precautions for user No data available

SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

Authorisations and/or restrictions on use 15.2 Chemical safety assessment

For this product a chemical safety assessment was not carried out

SECTION 16: Other information

Full text of H-Statements referred to under sections 2 and 3.

H226 Flammable liquid and vapour. H301 Toxic if swallowed. H311 Toxic in contact with skin. H312 Harmful in contact with skin. H314 Causes severe skin burns and eye damage. H315 Causes skin irritation. H317 May cause an allergic skin reaction. H319 Causes serious eye irritation. H330 Fatal if inhaled. H350 May cause cancer. H400 Very toxic to aquatic life. H410 Very toxic to aquatic life with long lasting effects.

Further information Copyright 2016 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge

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and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

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Sigma - H1758 Page 1 of 7

SIGMA-ALDRICH sigma-aldrich.com SAFETY DATA SHEET

according to Regulation (EC) No. 1907/2006 Version 6.1 Revision Date 15.07.2016

Print Date 10.11.2016 GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifiers Product name : Hydrochloric acid

Product Number : H1758 Brand : Sigma Index-No. : 017-002-01-X REACH No. : 01-2119484862-27-XXXX

CAS-No. : 7647-01-0

1.2 Relevant identified uses of the substance or mixture and uses advised against

Identified uses : Laboratory chemicals, Manufacture of substances

1.3 Details of the supplier of the safety data sheet

Company : Sigma-Aldrich Chemical Pvt Limited Industrial Area, Anekal Taluka Plot No 12, 12 Bommasandra - Jigani Link Road 560100 BANGALORE INDIA

1.4 Emergency telephone number

Emergency Phone # : +91 98802 05043

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture

Classification according to Regulation (EC) No 1272/2008 Corrosive to metals (Category 1), H290 Skin corrosion (Category 1B), H314 Specific target organ toxicity - single exposure (Category 3), Respiratory system, H335

For the full text of the H-Statements mentioned in this Section, see Section 16.

2.2 Label elements

Labelling according Regulation (EC) No 1272/2008 Pictogram

Signal word Danger Hazard statement(s) H290 May be corrosive to metals. H314 Causes severe skin burns and eye damage. H335 May cause respiratory irritation. Precautionary statement(s) P260 Do not breathe dust/ fume/ gas/ mist/ vapours/ spray. P280 Wear protective gloves/ protective clothing/ eye protection/ face

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protection. P303 + P361 + P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing.

Rinse skin with water/shower. P304 + P340 + P310 IF INHALED: Remove person to fresh air and keep comfortable for

breathing. Immediately call a POISON CENTER/doctor. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove

contact lenses, if present and easy to do. Continue rinsing. Supplemental Hazard Statements

none

2.3 Other hazards This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

SECTION 3: Composition/information on ingredients

3.2 Mixtures Formula : HCl Molecular weight : 36.46 g/mol Hazardous ingredients according to Regulation (EC) No 1272/2008

Component Classification Concentration

Hydrochloric acid

CAS-No. EC-No. Index-No. Registration number

7647-01-0 231-595-7 017-002-01-X 01-2119484862-27-XXXX

Met. Corr. 1; Skin Corr. 1B; STOT SE 3; H290, H314, H335 Concentration limits: >= 25 %: Skin Corr. 1B, H314; 10 - < 25 %: Skin Irrit. 2, H315; 10 - < 25 %: Eye Irrit. 2, H319; >= 10 %: STOT SE 3, H335; >= 0.1 %: Met. Corr. 1, H290;

>= 30 - < 50 %

For the full text of the H-Statements mentioned in this Section, see Section 16.

SECTION 4: First aid measures

4.1 Description of first aid measures

General advice Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact Take off contaminated clothing and shoes immediately. Wash off with soap and plenty of water. Consult a physician.

In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

4.2 Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

4.3 Indication of any immediate medical attention and special treatment needed No data available

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SECTION 5: Firefighting measures

5.1 Extinguishing media

Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

5.2 Special hazards arising from the substance or mixture Hydrogen chloride gas Hydrogen chloride gas

5.3 Advice for firefighters Wear self-contained breathing apparatus for firefighting if necessary.

5.4 Further information No data available

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures Wear respiratory protection. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. For personal protection see section 8.

6.2 Environmental precautions Do not let product enter drains.

6.3 Methods and materials for containment and cleaning up Soak up with inert absorbent material and dispose of as hazardous waste. Keep in suitable, closed containers for disposal.

6.4 Reference to other sections For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling Avoid contact with skin and eyes. Avoid inhalation of vapour or mist. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Storage class (TRGS 510): Non-combustible, corrosive hazardous materials

7.3 Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

8.1 Control parameters

8.2 Exposure controls

Appropriate engineering controls Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

Personal protective equipment

Eye/face protection Tightly fitting safety goggles. Faceshield (8-inch minimum). Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

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Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Full contact Material: Nitrile rubber Minimum layer thickness: 0.11 mm Break through time: 480 min Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M) Splash contact Material: Nitrile rubber Minimum layer thickness: 0.11 mm Break through time: 480 min Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail [email protected], test method: EN374 If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industria situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario. Body Protection Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use (US) or type ABEK (EN 14387) respirator cartridges as a backup to enginee protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Control of environmental exposure Do not let product enter drains.

SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties

a) Appearance Form: liquid Colour: light yellow

b) Odour pungent

c) Odour Threshold No data available

d) pH No data available

e) Melting point/freezing point

-30 °C

f) Initial boiling point and boiling range

> 100 °C - lit.

g) Flash point Not applicable

h) Evaporation rate No data available

i) Flammability (solid, gas) No data available

j) Upper/lower flammability or explosive limits

No data available

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k) Vapour pressure 170 mmHg at 21.1 °C 410 mmHg at 37.7 °C

l) Vapour density No data available

m) Relative density 1.2 g/cm3 at 25 °C

n) Water solubility soluble

o) Partition coefficient: n-octanol/water

No data available

p) Auto-ignition temperature

No data available

q) Decomposition temperature

No data available

r) Viscosity No data available

s) Explosive properties No data available

t) Oxidizing properties No data available

9.2 Other safety information No data available

SECTION 10: Stability and reactivity

10.1 Reactivity No data available

10.2 Chemical stability Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions No data available

10.4 Conditions to avoid No data available

10.5 Incompatible materials Bases, Amines, Alkali metals, Metals, permanganates, e.g. potassium permanganate, Fluorine, metal acetylides, hexalithium disilicide

10.6 Hazardous decomposition products Hazardous decomposition products formed under fire conditions. - Hydrogen chloride gas Other decomposition products - No data available Hazardous decomposition products formed under fire conditions. - Hydrogen chloride gas In the event of fire: see section 5

SECTION 11: Toxicological information

11.1 Information on toxicological effects

Acute toxicity No data availableHydrochloric acid Inhalation: Inhalation may provoke the following symptoms: Respiratory irritation Cough Difficulty in breathing Pneumonia(Hydrochloric acid)

Skin corrosion/irritation Skin - Rabbit(Hydrochloric acid) Result: Causes burns.

Serious eye damage/eye irritation Eyes - Rabbit(Hydrochloric acid) Result: Corrosive to eyes

Respiratory or skin sensitisation Did not cause sensitisation on laboratory animals.(Hydrochloric acid)

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Germ cell mutagenicity No data available(Hydrochloric acid)

Carcinogenicity This product is or contains a component that is not classifiable as to its classification.(Hydrochloric acid) (Hydrochloric acid)

IARC: 3 - Group 3: Not classifiable as to its carcinogenicity to humans (Hydrochloric acid)

Reproductive toxicity

No data available(Hydrochloric acid)

Specific target organ toxicity - single exposure The substance or mixture is classified as specific target organ toxicant, single exposure, category 3 with respiratory tract irritation.(Hydrochloric acid)

Specific target organ toxicity - repeated exposure The substance or mixture is not classified as specific target organ toxicant, repeated exposure.

Aspiration hazard No aspiration toxicity classification(Hydrochloric acid)

Additional Information RTECS: MW4025000 Inhalation of vapors may cause:, burning sensation, Cough, wheezing, Shortness of breath, spasm, inflammation and edema of the larynx, spasm, inflammation and edema of the bronchi, pneumonitis, pulmonary edema(Hydrochloric acid)

SECTION 12: Ecological information

12.1 Toxicity Toxicity to fish LC50 - Lepomis macrochirus (Bluegill) - 24.6 mg/l - 96 h(Hydrochloric acid) Toxicity to daphnia and other aquatic invertebrates

EC50 - Daphnia magna (Water flea) - 4.91 mg/l - 48 h(Hydrochloric acid)

12.2 Persistence and degradability No data available

12.3 Bioaccumulative potential No data available

12.4 Mobility in soil No data available(Hydrochloric acid)

12.5 Results of PBT and vPvB assessment This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

12.6 Other adverse effects May be harmful to aquatic organisms due to the shift of the pH. Do not empty into drains.

SECTION 13: Disposal considerations

13.1 Waste treatment methods

Product Offer surplus and non-recyclable solutions to a licensed disposal company.

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Contaminated packaging Dispose of as unused product.

SECTION 14: Transport information

14.1 UN number ADR/RID: 1789 IMDG: 1789 IATA: 1789

14.2 UN proper shipping name ADR/RID: HYDROCHLORIC ACID IMDG: HYDROCHLORIC ACID IATA: Hydrochloric acid

14.3 Transport hazard class(es) ADR/RID: 8 IMDG: 8 IATA: 8

14.4 Packaging group ADR/RID: II IMDG: II IATA: II

14.5 Environmental hazards ADR/RID: no IMDG Marine pollutant: no IATA: no

14.6 Special precautions for user No data available

SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

15.2 Chemical safety assessment For this product a chemical safety assessment was not carried out

SECTION 16: Other information

Full text of H-Statements referred to under sections 2 and 3.

H290 May be corrosive to metals. H314 Causes severe skin burns and eye damage. H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation.

Further information Copyright 2016 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

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SIGMA-ALDRICH sigma-aldrich.com SAFETY DATA SHEET

according to Regulation (EC) No. 1907/2006 Version 6.0 Revision Date 31.03.2016

Print Date 10.11.2016 GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifiers Product name : Hydrogen chloride

Product Number : 295426 Brand : Aldrich Index-No. : 017-002-00-2 REACH No. : 01-2119484862-27-XXXX

CAS-No. : 7647-01-0

1.2 Relevant identified uses of the substance or mixture and uses advised against

Identified uses : Laboratory chemicals, Manufacture of substances

1.3 Details of the supplier of the safety data sheet

Company : Sigma-Aldrich Chemical Pvt Limited Industrial Area, Anekal Taluka Plot No 12, 12 Bommasandra - Jigani Link Road 560100 BANGALORE INDIA

1.4 Emergency telephone number

Emergency Phone # : +91 98802 05043

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture

Classification according to Regulation (EC) No 1272/2008 Gases under pressure (Compressed gas), H280 Acute toxicity, Inhalation (Category 3), H331 Skin corrosion (Category 1A), H314

For the full text of the H-Statements mentioned in this Section, see Section 16.

2.2 Label elements

Labelling according Regulation (EC) No 1272/2008 Pictogram

Signal word Danger Hazard statement(s) H280 Contains gas under pressure; may explode if heated. H314 Causes severe skin burns and eye damage. H331 Toxic if inhaled. Precautionary statement(s) P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P280 Wear protective gloves/ protective clothing/ eye protection/ face

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protection. P303 + P361 + P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing.

Rinse skin with water/shower. P304 + P340 + P310 IF INHALED: Remove person to fresh air and keep comfortable for

breathing. Immediately call a POISON CENTER/doctor. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove

contact lenses, if present and easy to do. Continue rinsing. P403 + P233 Store in a well-ventilated place. Keep container tightly closed. Supplemental Hazard Statements

none

2.3 Other hazards This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

SECTION 3: Composition/information on ingredients

3.1 Substances Formula : HCl Molecular weight : 36.46 g/mol CAS-No. : 7647-01-0 EC-No. : 231-595-7 Index-No. : 017-002-00-2 Registration number : 01-2119484862-27-XXXX

Hazardous ingredients according to Regulation (EC) No 1272/2008

Component Classification Concentration

Hydrogen chloride (press. gas)

CAS-No. EC-No. Index-No. Registration number

7647-01-0 231-595-7 017-002-00-2 01-2119484862-27-XXXX

Press. Gas Compr. Gas; Acute Tox. 3; Skin Corr. 1A; H280, H331, H314

<= 100 %

For the full text of the H-Statements mentioned in this Section, see Section 16.

SECTION 4: First aid measures

4.1 Description of first aid measures

General advice Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact Take off contaminated clothing and shoes immediately. Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician.

In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

4.2 Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

4.3 Indication of any immediate medical attention and special treatment needed No data available

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SECTION 5: Firefighting measures

5.1 Extinguishing media

Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

5.2 Special hazards arising from the substance or mixture Hydrogen chloride gas

5.3 Advice for firefighters Wear self-contained breathing apparatus for firefighting if necessary.

5.4 Further information Use water spray to cool unopened containers.

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures Wear respiratory protection. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. For personal protection see section 8.

6.2 Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

6.3 Methods and materials for containment and cleaning up Clean up promptly by sweeping or vacuum.

6.4 Reference to other sections For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling Avoid contact with skin and eyes. Avoid inhalation of vapour or mist. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Gases

7.3 Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

8.1 Control parameters

8.2 Exposure controls

Appropriate engineering controls Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product.

Personal protective equipment

Eye/face protection Tightly fitting safety goggles. Faceshield (8-inch minimum). Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.

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The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Full contact Material: butyl-rubber Minimum layer thickness: 0.3 mm Break through time: 480 min Material tested:Butoject® (KCL 897 / Aldrich Z677647, Size M) Splash contact Material: Nitrile rubber Minimum layer thickness: 0.4 mm Break through time: 30 min Material tested:Camatril® (KCL 730 / Aldrich Z677442, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail [email protected], test method: EN374 If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industria situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario. Body Protection Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use (US) or type AXBEK (EN 14387) respirator cartridges as a backup to engine protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Control of environmental exposure Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties

a) Appearance Form: Compressed gas

b) Odour No data available

c) Odour Threshold No data available

d) pH No data available

e) Melting point/freezing point

Melting point/range: -114 °C - lit.

f) Initial boiling point and boiling range

-85 °C - lit.

g) Flash point No data available

h) Evaporation rate No data available

i) Flammability (solid, gas) No data available

j) Upper/lower flammability or explosive limits

No data available

k) Vapour pressure No data available

l) Vapour density No data available

m) Relative density 1.2 g/mL at 25 °C

n) Water solubility No data available

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o) Partition coefficient: n-octanol/water

No data available

p) Auto-ignition temperature

No data available

q) Decomposition temperature

No data available

r) Viscosity No data available

s) Explosive properties No data available

t) Oxidizing properties No data available

9.2 Other safety information No data available

SECTION 10: Stability and reactivity

10.1 Reactivity No data available

10.2 Chemical stability Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions No data available

10.4 Conditions to avoid No data available

10.5 Incompatible materials No data available

10.6 Hazardous decomposition products Hazardous decomposition products formed under fire conditions. - Hydrogen chloride gas Other decomposition products - No data available In the event of fire: see section 5

SECTION 11: Toxicological information

11.1 Information on toxicological effects

Acute toxicity LD50 Oral - Rabbit - 900 mg/kg(Hydrogen chloride (press. gas)) LC50 Inhalation - Rat - 4 h - 1562 ppm(Hydrogen chloride (press. gas))

Skin corrosion/irritation Extremely corrosive and destructive to tissue.(Hydrogen chloride (press. gas))

Serious eye damage/eye irritation No data available(Hydrogen chloride (press. gas))

Respiratory or skin sensitisation No data available(Hydrogen chloride (press. gas))

Germ cell mutagenicity No data available(Hydrogen chloride (press. gas))

Carcinogenicity

Reproductive toxicity

No data available(Hydrogen chloride (press. gas))

Specific target organ toxicity - single exposure No data available(Hydrogen chloride (press. gas))

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Specific target organ toxicity - repeated exposure No data available

Aspiration hazard No data available(Hydrogen chloride (press. gas))

Additional Information RTECS: Not available burning sensation, Cough, wheezing, laryngitis, Shortness of breath, spasm, inflammation and edema of the larynx, spasm, inflammation and edema of the bronchi, pneumonitis, pulmonary edema, Material is extremely destructive to tissue of the mucous membranes and upper respiratory tract, eyes, and skin., To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.(Hydrogen chloride (press. gas))

SECTION 12: Ecological information

12.1 Toxicity No data available

12.2 Persistence and degradability No data available

12.3 Bioaccumulative potential No data available

12.4 Mobility in soil No data available(Hydrogen chloride (press. gas))

12.5 Results of PBT and vPvB assessment This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

12.6 Other adverse effects No data available

SECTION 13: Disposal considerations

13.1 Waste treatment methods

Product Offer surplus and non-recyclable solutions to a licensed disposal company.

Contaminated packaging Dispose of as unused product.

SECTION 14: Transport information

14.1 UN number ADR/RID: 1050 IMDG: 1050 IATA: 1050

14.2 UN proper shipping name ADR/RID: HYDROGEN CHLORIDE, ANHYDROUS IMDG: HYDROGEN CHLORIDE, ANHYDROUS IATA: Hydrogen chloride, anhydrous Passenger Aircraft: Not permitted for transport Cargo Aircraft: Not permitted for transport

14.3 Transport hazard class(es) ADR/RID: 2.3 (8) IMDG: 2.3 (8) IATA: 2.3 (8)

14.4 Packaging group ADR/RID: - IMDG: - IATA: -

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Aldrich - 295426 Page 7 of 7

14.5 Environmental hazards ADR/RID: no IMDG Marine pollutant: no IATA: no

14.6 Special precautions for user No data available

SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

15.2 Chemical safety assessment For this product a chemical safety assessment was not carried out

SECTION 16: Other information

Full text of H-Statements referred to under sections 2 and 3.

H280 Contains gas under pressure; may explode if heated. H314 Causes severe skin burns and eye damage. H331 Toxic if inhaled.

Further information Copyright 2016 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

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Aldrich - 295396 Page 1 of 7

SIGMA-ALDRICH sigma-aldrich.com SAFETY DATA SHEET

according to Regulation (EC) No. 1907/2006 Version 6.0 Revision Date 31.03.2016

Print Date 10.11.2016 GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifiers Product name : Hydrogen

Product Number : 295396 Brand : Aldrich Index-No. : 001-001-00-9 REACH No. : A registration number is not available for this substance as the substance

or its uses are exempted from registration, the annual tonnage does not require a registration or the registration is envisaged for a later registration deadline.

CAS-No. : 1333-74-0

1.2 Relevant identified uses of the substance or mixture and uses advised against

Identified uses : Laboratory chemicals, Manufacture of substances

1.3 Details of the supplier of the safety data sheet

Company : Sigma-Aldrich Chemical Pvt Limited Industrial Area, Anekal Taluka Plot No 12, 12 Bommasandra - Jigani Link Road 560100 BANGALORE INDIA

1.4 Emergency telephone number

Emergency Phone # : +91 98802 05043

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture

Classification according to Regulation (EC) No 1272/2008 Flammable gases (Category 1), H220 Gases under pressure (Compressed gas), H280

For the full text of the H-Statements mentioned in this Section, see Section 16.

2.2 Label elements

Labelling according Regulation (EC) No 1272/2008 Pictogram

Signal word Danger Hazard statement(s) H220 Extremely flammable gas. H280 Contains gas under pressure; may explode if heated. Precautionary statement(s) P210 Keep away from heat, hot surfaces, sparks, open flames and other

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ignition sources. No smoking. P377 Leaking gas fire: Do not extinguish, unless leak can be stopped safely. P381 Eliminate all ignition sources if safe to do so. P410 + P403 Protect from sunlight. Store in a well-ventilated place. Supplemental Hazard Statements

none

2.3 Other hazards This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

SECTION 3: Composition/information on ingredients

3.1 Substances Formula : H<SB>2</> Molecular weight : 2.02 g/mol CAS-No. : 1333-74-0 EC-No. : 215-605-7 Index-No. : 001-001-00-9 No components need to be disclosed according to the applicable regulations.

For the full text of the H-Statements mentioned in this Section, see Section 16.

SECTION 4: First aid measures

4.1 Description of first aid measures

General advice Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact Wash off with soap and plenty of water. Consult a physician.

In case of eye contact Flush eyes with water as a precaution.

If swallowed Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

4.2 Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

4.3 Indication of any immediate medical attention and special treatment needed No data available

SECTION 5: Firefighting measures

5.1 Extinguishing media

Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

5.2 Special hazards arising from the substance or mixture

5.3 Advice for firefighters Wear self-contained breathing apparatus for firefighting if necessary.

5.4 Further information Use water spray to cool unopened containers.

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SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to form explosive concentrations. Vapours can accumulate in low areas. For personal protection see section 8.

6.2 Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

6.3 Methods and materials for containment and cleaning up Clean up promptly by sweeping or vacuum.

6.4 Reference to other sections For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling Avoid inhalation of vapour or mist. Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic charge. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

Contents under pressure. Storage class (TRGS 510): Gases

7.3 Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

8.1 Control parameters

8.2 Exposure controls

Appropriate engineering controls Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

Personal protective equipment

Eye/face protection Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Splash contact Material: butyl-rubber Minimum layer thickness: 0.3 mm Break through time: 120 min Material tested:Butoject® (KCL 897 / Aldrich Z677647, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail [email protected], test method: EN374

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If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industria situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario. Body Protection Impervious clothing, Flame retardant antistatic protective clothing., The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use (US) or type AXBEK (EN 14387) respirator cartridges as a backup to engine protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Control of environmental exposure Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties

a) Appearance Form: Compressed gas Colour: colourless

b) Odour No data available

c) Odour Threshold No data available

d) pH No data available

e) Melting point/freezing point

Melting point/range: -259.2 °C - lit.

f) Initial boiling point and boiling range

-252.8 °C - lit.

g) Flash point < -149.99 °C - closed cup

h) Evaporation rate No data available

i) Flammability (solid, gas) No data available

j) Upper/lower flammability or explosive limits

Upper explosion limit: 74.2 %(V) Lower explosion limit: 4 %(V)

k) Vapour pressure No data available

l) Vapour density 0.08

m) Relative density No data available

n) Water solubility 0.00196 g/l at 0 °C

o) Partition coefficient: n-octanol/water

No data available

p) Auto-ignition temperature

No data available

q) Decomposition temperature

No data available

r) Viscosity No data available

s) Explosive properties No data available

t) Oxidizing properties No data available

9.2 Other safety information

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Relative vapour density 0.08

SECTION 10: Stability and reactivity

10.1 Reactivity No data available

10.2 Chemical stability Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions No data available

10.4 Conditions to avoid Heat, flames and sparks.

10.5 Incompatible materials Oxidizing agents

10.6 Hazardous decomposition products Other decomposition products - No data available In the event of fire: see section 5

SECTION 11: Toxicological information

11.1 Information on toxicological effects

Acute toxicity No data availableHydrogen

Skin corrosion/irritation No data available(Hydrogen)

Serious eye damage/eye irritation No data available(Hydrogen)

Respiratory or skin sensitisation No data available(Hydrogen)

Germ cell mutagenicity No data available(Hydrogen)

Carcinogenicity

IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.

Reproductive toxicity No data available(Hydrogen)

Specific target organ toxicity - single exposure No data available(Hydrogen)

Specific target organ toxicity - repeated exposure No data available

Aspiration hazard No data available(Hydrogen)

Additional Information RTECS: MW8900000 To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.(Hydrogen)

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SECTION 12: Ecological information

12.1 Toxicity No data available

12.2 Persistence and degradability No data available

12.3 Bioaccumulative potential No data available

12.4 Mobility in soil No data available(Hydrogen)

12.5 Results of PBT and vPvB assessment This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

12.6 Other adverse effects No data available

SECTION 13: Disposal considerations

13.1 Waste treatment methods

Product Burn in a chemical incinerator equipped with an afterburner and scrubber b highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company.

Contaminated packaging Dispose of as unused product.

SECTION 14: Transport information

14.1 UN number ADR/RID: 1049 IMDG: 1049 IATA: 1049

14.2 UN proper shipping name ADR/RID: HYDROGEN, COMPRESSED IMDG: HYDROGEN, COMPRESSED IATA: Hydrogen, compressed Passenger Aircraft: Not permitted for transport

14.3 Transport hazard class(es) ADR/RID: 2.1 IMDG: 2.1 IATA: 2.1

14.4 Packaging group ADR/RID: - IMDG: - IATA: -

14.5 Environmental hazards ADR/RID: no IMDG Marine pollutant: no IATA: no

14.6 Special precautions for user No data available

SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

15.2 Chemical safety assessment For this product a chemical safety assessment was not carried out

SECTION 16: Other information

Full text of H-Statements referred to under sections 2 and 3.

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H220 Extremely flammable gas. H280 Contains gas under pressure; may explode if heated.

Further information Copyright 2016 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

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SIGMA-ALDRICH Material Safety Data Sheet Date Printed: 17/AUG/2009 Date Updated: 03/AUG/2007 Version 1.6 Regulation (EC) No 1907/2006 1 - Product and Company Information Product Name HYDROGEN PEROXIDE, 30-32 WT. % SOLUTION IN WATER, SEMICONDUCTOR GRADE, 99.999% METALS BASIS Product Number 316989 Company Sigma-Aldrich Korea Ltd., 698-84 Maeng-ri, Wonsam-myun, 449-871 Yongin-city, Kyunggi-do, Technical Phone # +82-31-329-9000 Fax +82-31-329-9090 E-mail Address [email protected] 2 - Hazards Identification SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT Harmful if swallowed. Risk of serious damage to eyes. 3 - Composition/Information on Ingredients Product Name CAS # EC no Annex I Index Number HYDROGEN PEROXIDE, 30% SOLUTION 7722-84-1 231-765-0 008-003-00-9 Ingredient Name Percent CAS # EC no Annex I Index Number HYDROGEN PEROXIDE 30 7722-84-1 231-765-0 008-003-00-9 Symbols: O-C R-Phrases: 5-8-20/22-35 Heating may cause an explosion. Contact with combustible material may cause fire. Harmful by inhalation and if swallowed. Causes severe burns. WATER 70 7732-18-5 231-791-2 None Formula H2O2 Synonyms Albone 35 * Albone 50 * Albone 70 * Albone 35CG * Albone 50CG * Albone 70CG * Hydrogen peroxide, solution, 30% * Interox * Kastone * Perone 30 * Perone 35 * Perone 50 4 - First Aid Measures AFTER INHALATION If inhaled, remove to fresh air. If breathing becomes difficult, call a physician. AFTER SKIN CONTACT In case of contact, immediately wash skin with soap and copious amounts of water.

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AFTER EYE CONTACT In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician. AFTER INGESTION If swallowed, wash out mouth with water provided person is conscious. Call a physician. 5 - Fire Fighting Measures EXTINGUISHING MEDIA Suitable: Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. SPECIAL RISKS Specific Hazard(s): Emits toxic fumes under fire conditions. SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes. 6 - Accidental Release Measures PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL Evacuate area. PROCEDURE(S) OF PERSONAL PRECAUTION(S) Wear self-contained breathing apparatus, rubber boots, and heavy rubber gloves. METHODS FOR CLEANING UP Absorb on sand or vermiculite and place in closed containers for disposal. Ventilate area and wash spill site after material pickup is complete. 7 - Handling and Storage HANDLING Directions for Safe Handling: Do not breathe vapor. Avoid contact with eyes, skin, and clothing. Avoid prolonged or repeated exposure. STORAGE Conditions of Storage: Keep tightly closed. Store at 2-8°C 8 - Exposure Controls / Personal Protection ENGINEERING CONTROLS Safety shower and eye bath. Mechanical exhaust required. GENERAL HYGIENE MEASURES Wash thoroughly after handling. PERSONAL PROTECTIVE EQUIPMENT Respiratory Protection: Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multi-purpose combination (US) or type AXBEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole SIAL - 316989 www.sigma-aldrich.com Page 2

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means of protection, use a full-face supplied air respirator. Hand Protection: Compatible chemical-resistant gloves. Eye Protection: Chemical safety goggles. 9 - Physical and Chemical Properties Appearance Physical State: Clear liquid Color: Colorless Property Value At Temperature or Pressure pH N/A BP/BP Range N/A MP/MP Range N/A Flash Point N/A Flammability N/A Autoignition Temp N/A Oxidizing Properties N/A Explosive Properties N/A Explosion Limits N/A Vapor Pressure N/A SG/Density 1.11 g/cm3 Partition Coefficient N/A Viscosity N/A Vapor Density N/A Saturated Vapor Conc. N/A Evaporation Rate N/A Bulk Density N/A Decomposition Temp. N/A Solvent Content N/A Water Content N/A Surface Tension N/A Conductivity N/A Miscellaneous Data N/A Solubility N/A 10 - Stability and Reactivity STABILITY Stable: Stable. Materials to Avoid: Strong oxidizing agents. HAZARDOUS DECOMPOSITION PRODUCTS Hazardous Decomposition Products: . HAZARDOUS POLYMERIZATION Hazardous Polymerization: Will not occur 11 - Toxicological Information RTECS NUMBER: MX0899000 ACUTE TOXICITY LDLO Oral Woman 2.626 mg/kg Remarks: Gastrointestinal:Nausea or vomiting. Lungs, Thorax, or Respiration:Cyanosis. Behavioral:Coma. LDLO SIAL - 316989 www.sigma-aldrich.com Page 3

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Oral Man 1429 mg/kg Remarks: Behavioral:Coma. Gastrointestinal:Changes in structure or function of esophagus. Gastrointestinal:Nausea or vomiting. LD50 Skin Rat 3000 mg/kg LD50 Intravenous Mouse >50 GM/KG LD50 Oral Rabbit 820 mg/kg Remarks: Gastrointestinal:Peritonitis. Blood:Pigmented or nucleated red bIood cells. Blood:Changes in leukocyte (WBC) count. SIGNS AND SYMPTOMS OF EXPOSURE To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated. ROUTE OF EXPOSURE Skin Contact: May cause skin irritation. Skin Absorption: May be harmful if absorbed through the skin. Eye Contact: Causes severe eye irritation. Inhalation: Material may be irritating to mucous membranes and upper respiratory tract. May be harmful if inhaled. Ingestion: Harmful if swallowed. TARGET ORGAN INFORMATION Eyes. Respiratory system. Skin. CHRONIC EXPOSURE - CARCINOGEN Result: This product is or contains a component that is not classifiable as to its carcinogenicity based on its IARC, ACGIH, NTP, or EPA classification. Mouse Route of Application: Oral Exposure Time: 2Y Result: Tumorigenic:Carcinogenic by RTECS criteria. Gastrointestinal:Tumors. Mouse Route of Application: Oral Exposure Time: 2Y Result: Gastrointestinal:Tumors. Tumorigenic:Carcinogenic by RTECS criteria. IARC CARCINOGEN LIST Rating: Group 3 CHRONIC EXPOSURE - MUTAGEN SIAL - 316989 www.sigma-aldrich.com Page 4

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Human 9 UMOL/L Cell Type: lymphocyte DNA damage Human 50 UMOL/L Cell Type: Embryo Other mutation test systems Human 20 UMOL/L Cell Type: Embryo Cytogenetic analysis Rat 50 UMOL/L Cell Type: lymphocyte DNA damage Hamster 250 UMOL/L Cell Type: ovary DNA inhibition Hamster 60 UMOL/L Cell Type: ovary Cytogenetic analysis Hamster 40 UMOL/L Cell Type: ovary Sister chromatid exchange Hamster 1 MMOL/L Cell Type: lung Mutation in mammalian somatic cells. 12 - Ecological Information No data available. 13 - Disposal Considerations SUBSTANCE DISPOSAL Contact a licensed professional waste disposal service to dispose of this material. Observe all federal, state, and local environmental regulations. 14 - Transport Information RID/ADR UN#: 2014 Class: 5.1 PG: II Subrisk: 8 Proper Shipping Name: Hydrogen peroxide, aqueous solution IMDG SIAL - 316989 www.sigma-aldrich.com Page 5

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UN#: 2014 Class: 5.1 PG: II Subrisk: 8 Proper Shipping Name: Hydrogen peroxide, aqueous solution Marine Pollutant: No Severe Marine Pollutant: No IATA UN#: 2014 Class: 5.1 PG: II Subrisk: 8 Proper Shipping Name: Hydrogen peroxide, aqueous solution Inhalation Packing Group I: No 15 - Regulatory Information CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES ANNEX I INDEX NUMBER: 008-003-00-9 INDICATION OF DANGER: Xn Harmful. R-PHRASES: 22-41 Harmful if swallowed. Risk of serious damage to eyes. S-PHRASES: 26-39 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear eye/face protection. COUNTRY SPECIFIC INFORMATION Germany WGK: 1 Self-Classification NORWAY Declaration Number: 68197 16 - Other Information WARRANTY The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Inc., shall not be held liable for any damage resulting from handling or from contact with the above product. See reverse side of invoice or packing slip for additional terms and conditions of sale. Copyright 2009 Sigma-Aldrich Co. License granted to make unlimited paper copies for internal use only. DISCLAIMER For R&D use only. Not for drug, household or other uses. SIAL - 316989 www.sigma-aldrich.com Page 6

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Katayama - 13-2600 Page 1 of 6

SIGMA-ALDRICH sigma-aldrich.com SAFETY DATA SHEET

according to Regulation (EC) No. 1907/2006 Version 6.0 Revision Date 08.11.2016

Print Date 10.11.2016 GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifiers Product name : Hyflo® Super-Cel®

Product Number : 13-2600 Brand : Katayama REACH No. : A registration number is not available for this substance as the substance

or its uses are exempted from registration, the annual tonnage does not require a registration or the registration is envisaged for a later registration deadline.

CAS-No. : 68855-54-9

1.2 Relevant identified uses of the substance or mixture and uses advised against

Identified uses : Laboratory chemicals, Manufacture of substances

1.3 Details of the supplier of the safety data sheet

Company : Sigma-Aldrich Chemical Pvt Limited Industrial Area, Anekal Taluka Plot No 12, 12 Bommasandra - Jigani Link Road 560100 BANGALORE INDIA

1.4 Emergency telephone number

Emergency Phone # : +91 98802 05043

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture

Classification according to Regulation (EC) No 1272/2008 Specific target organ toxicity - repeated exposure (Category 2), H373

For the full text of the H-Statements mentioned in this Section, see Section 16.

2.2 Label elements

Labelling according Regulation (EC) No 1272/2008 Pictogram

Signal word Warning Hazard statement(s) H373 May cause damage to organs through prolonged or repeated exposure. Precautionary statement(s) none Supplemental Hazard Statements

none

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2.3 Other hazards This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

SECTION 3: Composition/information on ingredients

3.2 Mixtures Synonyms : Celite 500 fine

Hazardous ingredients according to Regulation (EC) No 1272/2008

Component Classification Concentration

Diatomaceous earth (Calcined)

CAS-No. EC-No.

68855-54-9 272-489-0

STOT RE 2; H373 >= 90 - <= 100 %

Silicon dioxide

CAS-No. EC-No.

14464-46-1 238-455-4

STOT RE 2; H373 >= 80 - < 90 %

Quartz

CAS-No. EC-No.

14808-60-7 238-878-4

STOT RE 2; H373 >= 1 - < 10 %

For the full text of the H-Statements mentioned in this Section, see Section 16.

SECTION 4: First aid measures

4.1 Description of first aid measures

General advice Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact Wash off with soap and plenty of water. Consult a physician.

In case of eye contact Flush eyes with water as a precaution.

If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

4.2 Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

4.3 Indication of any immediate medical attention and special treatment needed No data available

SECTION 5: Firefighting measures

5.1 Extinguishing media

Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

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Katayama - 13-2600 Page 3 of 6

5.2 Special hazards arising from the substance or mixture silicon oxides

5.3 Advice for firefighters Wear self-contained breathing apparatus for firefighting if necessary.

5.4 Further information No data available

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

6.3 Methods and materials for containment and cleaning up Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.

6.4 Reference to other sections For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Non Combustible Solids

7.3 Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

8.1 Control parameters

8.2 Exposure controls

Appropriate engineering controls Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

Personal protective equipment

Eye/face protection Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Body Protection Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

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Respiratory protection For nuisance exposures use type P95 (US) or type P1 (EU EN 143) particle r (US) or type ABEK-P2 (EU EN 143) respirator cartridges. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Control of environmental exposure Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties

a) Appearance Form: solid

b) Odour No data available

c) Odour Threshold No data available

d) pH No data available

e) Melting point/freezing point

No data available

f) Initial boiling point and boiling range

No data available

g) Flash point No data available

h) Evaporation rate No data available

i) Flammability (solid, gas) No data available

j) Upper/lower flammability or explosive limits

No data available

k) Vapour pressure No data available

l) Vapour density No data available

m) Relative density No data available

n) Water solubility No data available

o) Partition coefficient: n-octanol/water

No data available

p) Auto-ignition temperature

No data available

q) Decomposition temperature

No data available

r) Viscosity No data available

s) Explosive properties No data available

t) Oxidizing properties No data available

9.2 Other safety information No data available

SECTION 10: Stability and reactivity

10.1 Reactivity No data available

10.2 Chemical stability Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions No data available

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10.4 Conditions to avoid No data available

10.5 Incompatible materials No data available

10.6 Hazardous decomposition products Hazardous decomposition products formed under fire conditions. - silicon oxides Other decomposition products - No data available In the event of fire: see section 5

SECTION 11: Toxicological information

11.1 Information on toxicological effects

Acute toxicity No data available

Skin corrosion/irritation No data available

Serious eye damage/eye irritation No data available

Respiratory or skin sensitisation No data available

Germ cell mutagenicity No data available

Carcinogenicity

IARC: 1 - Group 1: Carcinogenic to humans (Silicon dioxide)

IARC: 1 - Group 1: Carcinogenic to humans (Quartz)

Reproductive toxicity No data available

Specific target organ toxicity - single exposure No data available

Specific target organ toxicity - repeated exposure No data available

Aspiration hazard No data available

Additional Information RTECS: Not available

SECTION 12: Ecological information

12.1 Toxicity No data available

12.2 Persistence and degradability No data available

12.3 Bioaccumulative potential No data available

12.4 Mobility in soil No data available

12.5 Results of PBT and vPvB assessment This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

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12.6 Other adverse effects No data available

SECTION 13: Disposal considerations

13.1 Waste treatment methods

Product Offer surplus and non-recyclable solutions to a licensed disposal company. Dissolve or mix the material with a combustible solvent and burn in a chem scrubber.

Contaminated packaging Dispose of as unused product.

SECTION 14: Transport information

14.1 UN number ADR/RID: - IMDG: - IATA: -

14.2 UN proper shipping name ADR/RID: Not dangerous goods IMDG: Not dangerous goods IATA: Not dangerous goods

14.3 Transport hazard class(es) ADR/RID: - IMDG: - IATA: -

14.4 Packaging group ADR/RID: - IMDG: - IATA: -

14.5 Environmental hazards ADR/RID: no IMDG Marine pollutant: no IATA: no

14.6 Special precautions for user No data available

SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

15.2 Chemical safety assessment For this product a chemical safety assessment was not carried out

SECTION 16: Other information

Full text of H-Statements referred to under sections 2 and 3.

H373 May cause damage to organs through prolonged or repeated exposure.

Further information Copyright 2016 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

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SIGMA-ALDRICH sigma-aldrich.com SAFETY DATA SHEET

according to Regulation (EC) No. 1907/2006 Version 6.0 Revision Date 30.03.2016

Print Date 10.11.2016 GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifiers Product name : Isopropyl alcohol

Product Number : W292907 Brand : Aldrich Index-No. : 603-117-00-0 REACH No. : A registration number is not available for this substance as the substance

or its uses are exempted from registration, the annual tonnage does not require a registration or the registration is envisaged for a later registration deadline.

CAS-No. : 67-63-0

1.2 Relevant identified uses of the substance or mixture and uses advised against

Identified uses : Laboratory chemicals, Manufacture of substances

1.3 Details of the supplier of the safety data sheet

Company : Sigma-Aldrich Chemical Pvt Limited Industrial Area, Anekal Taluka Plot No 12, 12 Bommasandra - Jigani Link Road 560100 BANGALORE INDIA

1.4 Emergency telephone number

Emergency Phone # : +91 98802 05043

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture

Classification according to Regulation (EC) No 1272/2008 Flammable liquids (Category 2), H225 Eye irritation (Category 2), H319 Specific target organ toxicity - single exposure (Category 3), Central nervous system, H336

For the full text of the H-Statements mentioned in this Section, see Section 16.

2.2 Label elements

Labelling according Regulation (EC) No 1272/2008 Pictogram

Signal word Danger Hazard statement(s) H225 Highly flammable liquid and vapour. H319 Causes serious eye irritation. H336 May cause drowsiness or dizziness.

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Precautionary statement(s) P210 Keep away from heat/sparks/open flames/hot surfaces. No smoking. P261 Avoid breathing vapours. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove

contact lenses, if present and easy to do. Continue rinsing. Supplemental Hazard Statements

none

2.3 Other hazards This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

SECTION 3: Composition/information on ingredients

3.1 Substances Synonyms : 2-Propanol

sec-Propyl alcohol Isopropyl alcohol Isopropanol

Formula : C<SB>3</>H<SB>8</>O Molecular weight : 60.10 g/mol CAS-No. : 67-63-0 EC-No. : 200-661-7 Index-No. : 603-117-00-0 Hazardous ingredients according to Regulation (EC) No 1272/2008

Component Classification Concentration

2-Propanol

CAS-No. EC-No. Index-No.

67-63-0 200-661-7 603-117-00-0

Flam. Liq. 2; Eye Irrit. 2; STOT SE 3; H225, H319, H336

<= 100 %

For the full text of the H-Statements mentioned in this Section, see Section 16.

SECTION 4: First aid measures

4.1 Description of first aid measures

General advice Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact Wash off with soap and plenty of water. Consult a physician.

In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

4.2 Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

4.3 Indication of any immediate medical attention and special treatment needed No data available

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SECTION 5: Firefighting measures

5.1 Extinguishing media

Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

5.2 Special hazards arising from the substance or mixture Carbon oxides

5.3 Advice for firefighters Wear self-contained breathing apparatus for firefighting if necessary.

5.4 Further information Use water spray to cool unopened containers.

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures Use personal protective equipment. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to form explosive concentrations. Vapours can accumulate in low areas. For personal protection see section 8.

6.2 Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

6.3 Methods and materials for containment and cleaning up Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations (see section 13).

6.4 Reference to other sections For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling Avoid contact with skin and eyes. Avoid inhalation of vapour or mist. Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic charge. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

Handle and store under inert gas. hygroscopic Storage class (TRGS 510): Flammable Liquids

7.3 Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

8.1 Control parameters

8.2 Exposure controls

Appropriate engineering controls Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

Personal protective equipment

Eye/face protection Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

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Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Full contact Material: Nitrile rubber Minimum layer thickness: 0.4 mm Break through time: 480 min Material tested:Camatril® (KCL 730 / Aldrich Z677442, Size M) Splash contact Material: Nitrile rubber Minimum layer thickness: 0.2 mm Break through time: 60 min Material tested:Dermatril® P (KCL 743 / Aldrich Z677388, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail [email protected], test method: EN374 If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industria situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario. Body Protection Impervious clothing, Flame retardant antistatic protective clothing., The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use (US) or type ABEK (EN 14387) respirator cartridges as a backup to enginee protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Control of environmental exposure Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties

a) Appearance Form: liquid Colour: colourless

b) Odour alcohol-like

c) Odour Threshold No data available

d) pH No data available

e) Melting point/freezing point

Melting point/range: -89.5 °C - lit.

f) Initial boiling point and boiling range

82 °C - lit.

g) Flash point 12.0 °C - closed cup

h) Evaporation rate 3.0

i) Flammability (solid, gas) No data available

j) Upper/lower flammability or

Upper explosion limit: 12.7 %(V) Lower explosion limit: 2 %(V)

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explosive limits

k) Vapour pressure 32.4 mmHg at 20.0 °C 44.0 mmHg at 25.0 °C

l) Vapour density No data available

m) Relative density 0.785 g/cm3 at 25 °C

n) Water solubility completely soluble

o) Partition coefficient: n-octanol/water

log Pow: 0.05

p) Auto-ignition temperature

425.0 °C

q) Decomposition temperature

No data available

r) Viscosity No data available

s) Explosive properties No data available

t) Oxidizing properties No data available

9.2 Other safety information

Surface tension 20.8 mN/m at 25.0 °C

SECTION 10: Stability and reactivity

10.1 Reactivity No data available

10.2 Chemical stability Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions No data available

10.4 Conditions to avoid Heat, flames and sparks. Extremes of temperature and direct sunlight.

10.5 Incompatible materials Oxidizing agents, Acid anhydrides, Aluminium, Halogenated compounds, Acids

10.6 Hazardous decomposition products Hazardous decomposition products formed under fire conditions. - Carbon oxides Other decomposition products - No data available In the event of fire: see section 5

SECTION 11: Toxicological information

11.1 Information on toxicological effects

Acute toxicity LD50 Oral - Rat - 5,045 mg/kg(2-Propanol) Remarks: Behavioral:Altered sleep time (including change in righting reflex). Behavioral:Somnolence (general depressed activity). LC50 Inhalation - Rat - 8 h - 16000 ppm(2-Propanol) LD50 Dermal - Rabbit - 12,800 mg/kg(2-Propanol)

Skin corrosion/irritation Skin - Rabbit(2-Propanol) Result: Mild skin irritation

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Serious eye damage/eye irritation Eyes - Rabbit(2-Propanol) Result: Eye irritation - 24 h

Respiratory or skin sensitisation No data available(2-Propanol)

Germ cell mutagenicity No data available(2-Propanol)

Carcinogenicity This product is or contains a component that is not classifiable as to its classification.(2-Propanol) (2-Propanol)

IARC: 3 - Group 3: Not classifiable as to its carcinogenicity to humans (2-Propanol)

Reproductive toxicity No data available(2-Propanol)

Specific target organ toxicity - single exposure Inhalation, Oral - May cause drowsiness or dizziness.(2-Propanol)

Specific target organ toxicity - repeated exposure No data available

Aspiration hazard No data available(2-Propanol)

Additional Information RTECS: NT8050000 Central nervous system depression, prolonged or repeated exposure can cause:, Nausea, Headache, Vomiting, narcosis, Drowsiness, Overexposure may cause mild, reversible liver effects., Aspiration may lead to:, Lung oedema, Pneumonia(2-Propanol) To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.(2-Propanol) Kidney - Irregularities - Based on Human Evidence(2-Propanol)

SECTION 12: Ecological information

12.1 Toxicity Toxicity to fish LC50 - Pimephales promelas (fathead minnow) - 9,640.00 mg/l - 96 h(2-

Propanol) Toxicity to daphnia and other aquatic invertebrates

EC50 - Daphnia magna (Water flea) - 5,102.00 mg/l - 24 h(2-Propanol)

Immobilization EC50 - Daphnia magna (Water flea) - 6,851 mg/l - 24 h(2-

Propanol) Toxicity to algae EC50 - Desmodesmus subspicatus (green algae) - > 2,000.00 mg/l - 72 h(2-

Propanol) EC50 - Algae - > 1,000.00 mg/l - 24 h(2-Propanol)

12.2 Persistence and degradability No data available

12.3 Bioaccumulative potential No bioaccumulation is to be expected (log Pow <= 4).

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12.4 Mobility in soil No data available(2-Propanol)

12.5 Results of PBT and vPvB assessment This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

12.6 Other adverse effects No data available

SECTION 13: Disposal considerations

13.1 Waste treatment methods

Product Burn in a chemical incinerator equipped with an afterburner and scrubber b highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company.

Contaminated packaging Dispose of as unused product.

SECTION 14: Transport information

14.1 UN number ADR/RID: 1219 IMDG: 1219 IATA: 1219

14.2 UN proper shipping name ADR/RID: ISOPROPANOL IMDG: ISOPROPANOL IATA: Isopropanol

14.3 Transport hazard class(es) ADR/RID: 3 IMDG: 3 IATA: 3

14.4 Packaging group ADR/RID: II IMDG: II IATA: II

14.5 Environmental hazards ADR/RID: no IMDG Marine pollutant: no IATA: no

14.6 Special precautions for user No data available

SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

15.2 Chemical safety assessment For this product a chemical safety assessment was not carried out

SECTION 16: Other information

Full text of H-Statements referred to under sections 2 and 3.

H225 Highly flammable liquid and vapour. H319 Causes serious eye irritation. H336 May cause drowsiness or dizziness.

Further information Copyright 2016 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held

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liable for any damage resulting from handling or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

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Aldrich - 146455 Page 1 of 7

SIGMA-ALDRICH sigma-aldrich.com SAFETY DATA SHEET

according to Regulation (EC) No. 1907/2006 Version 6.0 Revision Date 31.03.2016

Print Date 10.11.2016 GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifiers Product name : Isovaleraldehyde

Product Number : 146455 Brand : Aldrich REACH No. : A registration number is not available for this substance as the substance

or its uses are exempted from registration, the annual tonnage does not require a registration or the registration is envisaged for a later registration deadline.

CAS-No. : 590-86-3

1.2 Relevant identified uses of the substance or mixture and uses advised against

Identified uses : Laboratory chemicals, Manufacture of substances

1.3 Details of the supplier of the safety data sheet

Company : Sigma-Aldrich Chemical Pvt Limited Industrial Area, Anekal Taluka Plot No 12, 12 Bommasandra - Jigani Link Road 560100 BANGALORE INDIA

1.4 Emergency telephone number

Emergency Phone # : +91 98802 05043

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture

Classification according to Regulation (EC) No 1272/2008 Flammable liquids (Category 2), H225 Eye irritation (Category 2), H319 Skin sensitisation (Category 1), H317 Specific target organ toxicity - single exposure (Category 3), Respiratory system, H335 Chronic aquatic toxicity (Category 2), H411

For the full text of the H-Statements mentioned in this Section, see Section 16.

2.2 Label elements

Labelling according Regulation (EC) No 1272/2008 Pictogram

Signal word Danger Hazard statement(s) H225 Highly flammable liquid and vapour. H317 May cause an allergic skin reaction. H319 Causes serious eye irritation.

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H335 May cause respiratory irritation. H411 Toxic to aquatic life with long lasting effects. Precautionary statement(s) P210 Keep away from heat, hot surfaces, sparks, open flames and other

ignition sources. No smoking. P261 Avoid breathing vapours. P273 Avoid release to the environment. P280 Wear protective gloves. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove

contact lenses, if present and easy to do. Continue rinsing. Supplemental Hazard Statements

none

2.3 Other hazards This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher. Stench.

SECTION 3: Composition/information on ingredients

3.1 Substances Synonyms : 3-Methylbutyraldehyde

Formula : C<SB>5</>H<SB>10</>O Molecular weight : 86.13 g/mol CAS-No. : 590-86-3 EC-No. : 209-691-5 Hazardous ingredients according to Regulation (EC) No 1272/2008

Component Classification Concentration

Isovaleraldehyde

CAS-No. EC-No.

590-86-3 209-691-5

Flam. Liq. 2; Eye Irrit. 2; Skin Sens. 1; STOT SE 3; Aquatic Chronic 2; H225, H319, H317, H335, H411

<= 100 %

For the full text of the H-Statements mentioned in this Section, see Section 16.

SECTION 4: First aid measures

4.1 Description of first aid measures

General advice Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact Wash off with soap and plenty of water. Consult a physician.

In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

4.2 Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

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4.3 Indication of any immediate medical attention and special treatment needed No data available

SECTION 5: Firefighting measures

5.1 Extinguishing media

Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

5.2 Special hazards arising from the substance or mixture Carbon oxides

5.3 Advice for firefighters Wear self-contained breathing apparatus for firefighting if necessary.

5.4 Further information Use water spray to cool unopened containers.

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures Use personal protective equipment. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to form explosive concentrations. Vapours can accumulate in low areas. For personal protection see section 8.

6.2 Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

6.3 Methods and materials for containment and cleaning up Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations (see section 13).

6.4 Reference to other sections For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling Avoid contact with skin and eyes. Avoid inhalation of vapour or mist. Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic charge. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

Recommended storage temperature 2 - 8 °C

Handle and store under inert gas. Air and light sensitive. Storage class (TRGS 510): Flammable liquids

7.3 Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

8.1 Control parameters

8.2 Exposure controls

Appropriate engineering controls Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

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Personal protective equipment

Eye/face protection Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Splash contact Material: butyl-rubber Minimum layer thickness: 0.3 mm Break through time: 30 min Material tested:Butoject® (KCL 897 / Aldrich Z677647, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail [email protected], test method: EN374 If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industria situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario. Body Protection Complete suit protecting against chemicals, Flame retardant antistatic protective clothing., The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use (US) or type ABEK (EN 14387) respirator cartridges as a backup to enginee protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Control of environmental exposure Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties

a) Appearance Form: clear, liquid Colour: colourless

b) Odour unpleasant

c) Odour Threshold No data available

d) pH No data available

e) Melting point/freezing point

Freezing point: < -89.99 °C

f) Initial boiling point and boiling range

90 °C - lit.

g) Flash point -4.99 °C - closed cup

h) Evaporation rate No data available

i) Flammability (solid, gas) No data available

j) Upper/lower No data available

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Aldrich - 146455 Page 5 of 7

flammability or explosive limits

k) Vapour pressure 30 mmHg at 20 °C

l) Vapour density 2.97 - (Air = 1.0)

m) Relative density 0.803 g/cm3 at 25 °C

n) Water solubility 15 g/l at 20 °C - OECD Test Guideline 105 - soluble

o) Partition coefficient: n-octanol/water

log Pow: 1.5 at 25 °C

p) Auto-ignition temperature

210 °C at 1,020 hPa

q) Decomposition temperature

No data available

r) Viscosity 0.69 mm2/s at 20 °C -

s) Explosive properties No data available

t) Oxidizing properties No data available

9.2 Other safety information

Relative vapour density 2.97 - (Air = 1.0)

SECTION 10: Stability and reactivity

10.1 Reactivity No data available

10.2 Chemical stability Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions No data available

10.4 Conditions to avoid Heat, flames and sparks.

10.5 Incompatible materials Oxidizing agents, Strong bases, Strong reducing agents

10.6 Hazardous decomposition products Hazardous decomposition products formed under fire conditions. - Carbon oxides Other decomposition products - No data available In the event of fire: see section 5

SECTION 11: Toxicological information

11.1 Information on toxicological effects

Acute toxicity LD50 Oral - Rat - 5,600 mg/kg(Isovaleraldehyde) Remarks: Behavioral:Somnolence (general depressed activity). LD50 Oral - Rat - 5,740 mg/kg(Isovaleraldehyde) (OECD Test Guideline 401) LC50 Inhalation - Rat - 4 h - 42,700 mg/m3(Isovaleraldehyde) Remarks: Behavioral:Altered sleep time (including change in righting reflex). Gastrointestinal:Changes in structure or function of salivary glands. LD50 Dermal - Rabbit - 2,534 mg/kg(Isovaleraldehyde) Remarks: Liver:Other changes. Prolonged skin contact may cause skin irritation and/or dermatitis.

Skin corrosion/irritation Skin - Rabbit(Isovaleraldehyde) Result: Mild skin irritation - 24 h

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Serious eye damage/eye irritation Eyes - Rabbit(Isovaleraldehyde) Result: Irritating to eyes. - 8 d

Respiratory or skin sensitisation The preceding data, or interpretation of data, was determined using Quantitative Structure Activity Relationship (QSAR) modeling.(Isovaleraldehyde)

Germ cell mutagenicity No data available(Isovaleraldehyde)

Carcinogenicity

IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.

Reproductive toxicity No data available(Isovaleraldehyde)

Specific target organ toxicity - single exposure Inhalation - May cause respiratory irritation. - Respiratory system(Isovaleraldehyde)

Specific target organ toxicity - repeated exposure No data available

Aspiration hazard No data available(Isovaleraldehyde)

Additional Information RTECS: ES3450000 Nausea, Headache, Vomiting, To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.(Isovaleraldehyde)

SECTION 12: Ecological information

12.1 Toxicity Toxicity to fish LC50 - Pimephales promelas (fathead minnow) - 3.25 mg/l - 96

h(Isovaleraldehyde) Toxicity to daphnia and other aquatic invertebrates

EC50 - Daphnia magna (Water flea) - 177 mg/l - 48 h(Isovaleraldehyde)

Toxicity to algae ErC50 - Desmodesmus subspicatus (Scenedesmus subspicatus) - 113 mg/l -

72 h(Isovaleraldehyde)

12.2 Persistence and degradability Biodegradability Result: 50 % - Not readily biodegradable.

(OECD Test Guideline 301D)

12.3 Bioaccumulative potential Does not bioaccumulate.

12.4 Mobility in soil No data available(Isovaleraldehyde)

12.5 Results of PBT and vPvB assessment This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

12.6 Other adverse effects Toxic to aquatic life with long lasting effects.

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No data available

SECTION 13: Disposal considerations

13.1 Waste treatment methods

Product Burn in a chemical incinerator equipped with an afterburner and scrubber b highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company.

Contaminated packaging Dispose of as unused product.

SECTION 14: Transport information

14.1 UN number ADR/RID: 1989 IMDG: 1989 IATA: 1989

14.2 UN proper shipping name ADR/RID: ALDEHYDES, N.O.S. (Isovaleraldehyde) IMDG: ALDEHYDES, N.O.S. (Isovaleraldehyde) IATA: Aldehydes, n.o.s. (Isovaleraldehyde)

14.3 Transport hazard class(es) ADR/RID: 3 IMDG: 3 IATA: 3

14.4 Packaging group ADR/RID: II IMDG: II IATA: II

14.5 Environmental hazards ADR/RID: no IMDG Marine pollutant: no IATA: no

14.6 Special precautions for user No data available

SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

15.2 Chemical safety assessment For this product a chemical safety assessment was not carried out

SECTION 16: Other information

Full text of H-Statements referred to under sections 2 and 3.

H225 Highly flammable liquid and vapour. H317 May cause an allergic skin reaction. H319 Causes serious eye irritation. H335 May cause respiratory irritation. H411 Toxic to aquatic life with long lasting effects.

Further information Copyright 2016 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

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SIGMA-ALDRICH sigma-aldrich.com SAFETY DATA SHEET

according to Regulation (EC) No. 1907/2006 Version 6.0 Revision Date 30.03.2016

Print Date 10.11.2016 GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifiers Product name : Methanesulfonyl chloride

Product Number : 471259 Brand : Aldrich REACH No. : A registration number is not available for this substance as the substance

or its uses are exempted from registration, the annual tonnage does not require a registration or the registration is envisaged for a later registration deadline.

CAS-No. : 124-63-0

1.2 Relevant identified uses of the substance or mixture and uses advised against

Identified uses : Laboratory chemicals, Manufacture of substances

1.3 Details of the supplier of the safety data sheet

Company : Sigma-Aldrich Chemical Pvt Limited Industrial Area, Anekal Taluka Plot No 12, 12 Bommasandra - Jigani Link Road 560100 BANGALORE INDIA

1.4 Emergency telephone number

Emergency Phone # : +91 98802 05043

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture

Classification according to Regulation (EC) No 1272/2008 Acute toxicity, Oral (Category 2), H300 Acute toxicity, Inhalation (Category 1), H330 Acute toxicity, Dermal (Category 2), H310 Skin corrosion (Category 1B), H314 Specific target organ toxicity - single exposure (Category 3), H335

For the full text of the H-Statements mentioned in this Section, see Section 16.

2.2 Label elements

Labelling according Regulation (EC) No 1272/2008 Pictogram

Signal word Danger Hazard statement(s) H300 + H310 + H330 Fatal if swallowed, in contact with skin or if inhaled H314 Causes severe skin burns and eye damage. H335 May cause respiratory irritation.

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Precautionary statement(s) P260 Do not breathe dust/ fume/ gas/ mist/ vapours/ spray. P264 Wash hands thoroughly after handling. P280 Wear protective gloves/ protective clothing/ eye protection/ face

protection. P284 Wear respiratory protection. P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor. P302 + P350 IF ON SKIN: Gently wash with plenty of soap and water. Supplemental Hazard Statements

none

2.3 Other hazards This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

SECTION 3: Composition/information on ingredients

3.1 Substances Synonyms : Mesyl chloride

Formula : CH3ClO2S

Molecular weight : 114.55 g/mol CAS-No. : 124-63-0 EC-No. : 204-706-1 Hazardous ingredients according to Regulation (EC) No 1272/2008

Component Classification Concentration

Methanesulphonyl chloride

CAS-No. EC-No.

124-63-0 204-706-1

Acute Tox. 2; Acute Tox. 1; Acute Tox. 2; Skin Corr. 1B; STOT SE 3; H300, H330, H310, H314, H335

<= 100 %

For the full text of the H-Statements mentioned in this Section, see Section 16.

SECTION 4: First aid measures

4.1 Description of first aid measures

General advice Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact Take off contaminated clothing and shoes immediately. Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician.

In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

4.2 Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

4.3 Indication of any immediate medical attention and special treatment needed No data available

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SECTION 5: Firefighting measures

5.1 Extinguishing media

Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

5.2 Special hazards arising from the substance or mixture Sulphur oxides, Hydrogen chloride gas

5.3 Advice for firefighters Wear self-contained breathing apparatus for firefighting if necessary.

5.4 Further information Water hydrolyzes material liberating acidic gas which in contact with meta hydrogen gas.

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures Wear respiratory protection. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. For personal protection see section 8.

6.2 Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

6.3 Methods and materials for containment and cleaning up Soak up with inert absorbent material and dispose of as hazardous waste. Keep in suitable, closed containers for disposal.

6.4 Reference to other sections For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling Avoid contact with skin and eyes. Avoid inhalation of vapour or mist. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities Handle under nitrogen, protect from moisture. Store under nitrogen. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

Recommended storage temperature 2 - 8 °C

Moisture sensitive. Storage class (TRGS 510): Combustible liquids, toxic

7.3 Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

8.1 Control parameters

8.2 Exposure controls

Appropriate engineering controls Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product.

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Personal protective equipment

Eye/face protection Tightly fitting safety goggles. Faceshield (8-inch minimum). Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Full contact Material: butyl-rubber Minimum layer thickness: 0.3 mm Break through time: 480 min Material tested:Butoject® (KCL 897 / Aldrich Z677647, Size M) Splash contact Material: Nitrile rubber Minimum layer thickness: 0.4 mm Break through time: 30 min Material tested:Camatril® (KCL 730 / Aldrich Z677442, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail [email protected], test method: EN374 If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industria situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario. Body Protection Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use (US) or type ABEK (EN 14387) respirator cartridges as a backup to enginee protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Control of environmental exposure Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties

a) Appearance Form: liquid Colour: colourless

b) Odour No data available

c) Odour Threshold No data available

d) pH No data available

e) Melting point/freezing point

No data available

f) Initial boiling point and boiling range

60 °C at 28 hPa - lit.

g) Flash point No data available

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h) Evaporation rate No data available

i) Flammability (solid, gas) No data available

j) Upper/lower flammability or explosive limits

No data available

k) Vapour pressure 12 hPa at 53 °C

l) Vapour density 3.9

m) Relative density 1.48 g/cm3 at 25 °C

n) Water solubility No data available

o) Partition coefficient: n-octanol/water

No data available

p) Auto-ignition temperature

No data available

q) Decomposition temperature

No data available

r) Viscosity No data available

s) Explosive properties No data available

t) Oxidizing properties No data available

9.2 Other safety information

Relative vapour density 3.9

SECTION 10: Stability and reactivity

10.1 Reactivity No data available

10.2 Chemical stability Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions No data available

10.4 Conditions to avoid Water hydrolyzes material liberating acidic gas which in contact with meta hydrogen gas.

10.5 Incompatible materials Strong bases, Oxidizing agents, Alcohols

10.6 Hazardous decomposition products Other decomposition products - No data available Hazardous decomposition products formed under fire conditions. - Sulphur oxides, Hydrogen chloride gas In the event of fire: see section 5

SECTION 11: Toxicological information

11.1 Information on toxicological effects

Acute toxicity LD50 Oral - Mouse - 200 mg/kg(Methanesulphonyl chloride) LC50 Inhalation - Rat - 4 h - 25 ppm(Methanesulphonyl chloride) LD50 Dermal - Rabbit - 200 - 2,000 mg/kg(Methanesulphonyl chloride) LD50 Intraperitoneal - Mouse - 10 mg/kg(Methanesulphonyl chloride)

Skin corrosion/irritation Skin - Rabbit(Methanesulphonyl chloride) Result: Severe skin irritation

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(Draize Test)

Serious eye damage/eye irritation Eyes - Rabbit(Methanesulphonyl chloride) Result: Severe eye irritation (Draize Test)

Respiratory or skin sensitisation No data available(Methanesulphonyl chloride)

Germ cell mutagenicity No data available(Methanesulphonyl chloride)

Carcinogenicity

IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.

Reproductive toxicity No data available(Methanesulphonyl chloride)

Specific target organ toxicity - single exposure May cause respiratory irritation.(Methanesulphonyl chloride)

Specific target organ toxicity - repeated exposure No data available

Aspiration hazard No data available(Methanesulphonyl chloride)

Additional Information RTECS: PB2790000 Material is extremely destructive to tissue of the mucous membranes and upper respiratory tract, eyes, and skin., Inhalation may provoke the following symptoms:, spasm, inflammation and edema of the bronchi, pulmonary edema, Aspiration or inhalation may cause chemical pneumonitis., Symptoms of exposure may include burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea, and vomiting., To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.(Methanesulphonyl chloride)

SECTION 12: Ecological information

12.1 Toxicity No data available

12.2 Persistence and degradability No data available

12.3 Bioaccumulative potential No data available

12.4 Mobility in soil No data available(Methanesulphonyl chloride)

12.5 Results of PBT and vPvB assessment This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

12.6 Other adverse effects No data available

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SECTION 13: Disposal considerations

13.1 Waste treatment methods

Product Offer surplus and non-recyclable solutions to a licensed disposal company.

Contaminated packaging Dispose of as unused product.

SECTION 14: Transport information

14.1 UN number ADR/RID: 3246 IMDG: 3246 IATA: 3246

14.2 UN proper shipping name ADR/RID: METHANESULPHONYL CHLORIDE IMDG: METHANESULPHONYL CHLORIDE IATA: Methanesulphonyl chloride Passenger Aircraft: Not permitted for transport Cargo Aircraft: Not permitted for transport

14.3 Transport hazard class(es) ADR/RID: 6.1 (8) IMDG: 6.1 (8) IATA: 6.1 (8)

14.4 Packaging group ADR/RID: I IMDG: I IATA: -

14.5 Environmental hazards ADR/RID: no IMDG Marine pollutant: no IATA: no

14.6 Special precautions for user No data available

SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

15.2 Chemical safety assessment For this product a chemical safety assessment was not carried out

SECTION 16: Other information

Full text of H-Statements referred to under sections 2 and 3.

H300 Fatal if swallowed. H300 + H310 + H330

Fatal if swallowed, in contact with skin or if inhaled

H310 Fatal in contact with skin. H314 Causes severe skin burns and eye damage. H330 Fatal if inhaled. H335 May cause respiratory irritation.

Further information Copyright 2016 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

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Sigma-Aldrich - 322415 Page 1 of 7

SIGMA-ALDRICH sigma-aldrich.com SAFETY DATA SHEET

according to Regulation (EC) No. 1907/2006 Version 6.0 Revision Date 30.03.2016

Print Date 10.11.2016 GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifiers Product name : Methanol

Product Number : 322415 Brand : Sigma-Aldrich Index-No. : 603-001-00-X REACH No. : 01-2119433307-44-XXXX

CAS-No. : 67-56-1

1.2 Relevant identified uses of the substance or mixture and uses advised against

Identified uses : Laboratory chemicals, Manufacture of substances

1.3 Details of the supplier of the safety data sheet

Company : Sigma-Aldrich Chemical Pvt Limited Industrial Area, Anekal Taluka Plot No 12, 12 Bommasandra - Jigani Link Road 560100 BANGALORE INDIA

1.4 Emergency telephone number

Emergency Phone # : +91 98802 05043

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture

Classification according to Regulation (EC) No 1272/2008 Flammable liquids (Category 2), H225 Acute toxicity, Oral (Category 3), H301 Acute toxicity, Inhalation (Category 3), H331 Acute toxicity, Dermal (Category 3), H311 Specific target organ toxicity - single exposure (Category 1), H370

For the full text of the H-Statements mentioned in this Section, see Section 16.

2.2 Label elements

Labelling according Regulation (EC) No 1272/2008 Pictogram

Signal word Danger Hazard statement(s) H225 Highly flammable liquid and vapour. H301 + H311 + H331 Toxic if swallowed, in contact with skin or if inhaled H370 Causes damage to organs.

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Precautionary statement(s) P210 Keep away from heat, hot surfaces, sparks, open flames and other

ignition sources. No smoking. P280 Wear protective gloves/ protective clothing. P302 + P352 + P312 IF ON SKIN: Wash with plenty of water.Call a POISON CENTER/doctor if

you feel unwell. P304 + P340 + P311 IF INHALED: Remove person to fresh air and keep comfortable for

breathing. Call a POISON CENTER/doctor. P370 + P378 In case of fire: Use dry powder or dry sand to extinguish. P403 + P235 Store in a well-ventilated place. Keep cool. Supplemental Hazard Statements

none

2.3 Other hazards This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

SECTION 3: Composition/information on ingredients

3.1 Substances Synonyms : Methyl alcohol

Formula : CH4O

Molecular weight : 32.04 g/mol CAS-No. : 67-56-1 EC-No. : 200-659-6 Index-No. : 603-001-00-X Registration number : 01-2119433307-44-XXXX

No components need to be disclosed according to the applicable regulations.

For the full text of the H-Statements mentioned in this Section, see Section 16.

SECTION 4: First aid measures

4.1 Description of first aid measures

General advice Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician.

In case of eye contact Flush eyes with water as a precaution.

If swallowed Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

Notes to physician Dizziness Drowsiness metabolic acidosis Blurred vision Seizures. Coma Blindness death

4.2 Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

4.3 Indication of any immediate medical attention and special treatment needed No data available

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SECTION 5: Firefighting measures

5.1 Extinguishing media

Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

5.2 Special hazards arising from the substance or mixture Carbon oxides

5.3 Advice for firefighters Wear self-contained breathing apparatus for firefighting if necessary.

5.4 Further information Use water spray to cool unopened containers.

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures Wear respiratory protection. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to form explosive concentrations. Vapours can accumulate in low areas. For personal protection see section 8.

6.2 Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

6.3 Methods and materials for containment and cleaning up Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations (see section 13).

6.4 Reference to other sections For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling Avoid contact with skin and eyes. Avoid inhalation of vapour or mist. Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic charge. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Storage class (TRGS 510): Flammable liquids

7.3 Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

8.1 Control parameters

Derived No Effect Level (DNEL)

Application Area Exposure routes

Health effect Value

Workers Skin contact Long-term systemic effects 40mg/kg BW/d

Consumers Skin contact Long-term systemic effects 8mg/kg BW/d

Consumers Ingestion Long-term systemic effects 8mg/kg BW/d

Workers Skin contact Acute systemic effects 40mg/kg BW/d

Consumers Skin contact Acute systemic effects 8mg/kg BW/d

Consumers Ingestion Acute systemic effects 8mg/kg BW/d

Workers Inhalation Acute systemic effects 260 mg/m3

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Workers Inhalation Acute local effects 260 mg/m3

Workers Inhalation Long-term systemic effects 260 mg/m3

Workers Inhalation Long-term local effects 260 mg/m3

Consumers Inhalation Acute systemic effects 50 mg/m3

Consumers Inhalation Acute local effects 50 mg/m3

Consumers Inhalation Long-term systemic effects 50 mg/m3

Consumers Inhalation Long-term local effects 50 mg/m3

Predicted No Effect Concentration (PNEC)

Compartment Value

Soil 23.5 mg/kg

Marine water 15.4 mg/l

Fresh water 154 mg/l

Fresh water sediment 570.4 mg/kg

Onsite sewage treatment plant 100 mg/kg

8.2 Exposure controls

Appropriate engineering controls Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product.

Personal protective equipment

Eye/face protection Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Full contact Material: butyl-rubber Minimum layer thickness: 0.3 mm Break through time: 480 min Material tested:Butoject® (KCL 897 / Aldrich Z677647, Size M) Splash contact Material: Nitrile rubber Minimum layer thickness: 0.4 mm Break through time: 31 min Material tested:Camatril® (KCL 730 / Aldrich Z677442, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail [email protected], test method: EN374 If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industria situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario. Body Protection Complete suit protecting against chemicals, Flame retardant antistatic protective clothing., The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use (US) or type AXBEK (EN 14387) respirator cartridges as a backup to engine protection, use a full-face supplied air

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respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Control of environmental exposure Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties

a) Appearance Form: liquid Colour: colourless

b) Odour pungent

c) Odour Threshold No data available

d) pH No data available

e) Melting point/freezing point

Melting point/range: -98 °C

f) Initial boiling point and boiling range

64.7 °C

g) Flash point 9.7 °C - closed cup

h) Evaporation rate No data available

i) Flammability (solid, gas) No data available

j) Upper/lower flammability or explosive limits

Upper explosion limit: 36 %(V) Lower explosion limit: 6 %(V)

k) Vapour pressure 97.7 mmHg at 20.0 °C 410.0 mmHg at 50.0 °C 169.27 hPa at 25.0 °C

l) Vapour density 1.11

m) Relative density 0.791 g/mL at 25 °C

n) Water solubility completely miscible

o) Partition coefficient: n-octanol/water

log Pow: -0.77

p) Auto-ignition temperature

455.0 °C at 1,013 hPa

q) Decomposition temperature

No data available

r) Viscosity No data available

s) Explosive properties Not explosive

t) Oxidizing properties The substance or mixture is not classified as oxidizing.

9.2 Other safety information

Minimum ignition energy 0.14 mJ

Conductivity < 1 µS/cm

Relative vapour density 1.11

SECTION 10: Stability and reactivity

10.1 Reactivity No data available

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10.2 Chemical stability Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions No data available

10.4 Conditions to avoid Heat, flames and sparks.

10.5 Incompatible materials Acid chlorides, Acid anhydrides, Oxidizing agents, Alkali metals, Reducing agents, Acids

10.6 Hazardous decomposition products Hazardous decomposition products formed under fire conditions. - Carbon oxides Other decomposition products - No data available In the event of fire: see section 5

SECTION 11: Toxicological information

11.1 Information on toxicological effects

Acute toxicity

Skin corrosion/irritation

Serious eye damage/eye irritation

Respiratory or skin sensitisation

Germ cell mutagenicity

Carcinogenicity

IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.

Reproductive toxicity

Specific target organ toxicity - single exposure

Specific target organ toxicity - repeated exposure

Aspiration hazard

Additional Information RTECS: PC1400000

SECTION 12: Ecological information

12.1 Toxicity

12.2 Persistence and degradability

12.3 Bioaccumulative potential

12.4 Mobility in soil

12.5 Results of PBT and vPvB assessment This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

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12.6 Other adverse effects

SECTION 13: Disposal considerations

13.1 Waste treatment methods

Product Burn in a chemical incinerator equipped with an afterburner and scrubber b highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company.

Contaminated packaging Dispose of as unused product.

SECTION 14: Transport information

14.1 UN number ADR/RID: 1230 IMDG: 1230 IATA: 1230

14.2 UN proper shipping name ADR/RID: METHANOL IMDG: METHANOL IATA: Methanol

14.3 Transport hazard class(es) ADR/RID: 3 (6.1) IMDG: 3 (6.1) IATA: 3 (6.1)

14.4 Packaging group ADR/RID: II IMDG: II IATA: II

14.5 Environmental hazards ADR/RID: no IMDG Marine pollutant: no IATA: no

14.6 Special precautions for user No data available

SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

15.2 Chemical safety assessment A Chemical Safety Assessment has been carried out for this substance.

SECTION 16: Other information

Full text of H-Statements referred to under sections 2 and 3.

Further information Copyright 2016 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

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SIGMA-ALDRICH sigma-aldrich.com SAFETY DATA SHEET

according to Regulation (EC) No. 1907/2006 Version 6.0 Revision Date 31.03.2016

Print Date 10.11.2016 GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifiers Product name : Methanolic HCl

Product Number : 33050-U Brand : Supelco REACH No. : A registration number is not available for this substance as the substance

or its uses are exempted from registration, the annual tonnage does not require a registration or the registration is envisaged for a later registration deadline.

1.2 Relevant identified uses of the substance or mixture and uses advised against

Identified uses : Laboratory chemicals, Manufacture of substances

1.3 Details of the supplier of the safety data sheet

Company : Sigma-Aldrich Chemical Pvt Limited Industrial Area, Anekal Taluka Plot No 12, 12 Bommasandra - Jigani Link Road 560100 BANGALORE INDIA

1.4 Emergency telephone number

Emergency Phone # : +91 98802 05043

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture

Classification according to Regulation (EC) No 1272/2008 Flammable liquids (Category 2), H225 Corrosive to metals (Category 1), H290 Acute toxicity, Oral (Category 3), H301 Acute toxicity, Inhalation (Category 3), H331 Acute toxicity, Dermal (Category 3), H311 Skin irritation (Category 2), H315 Eye irritation (Category 2), H319 Specific target organ toxicity - single exposure (Category 1), H370 Specific target organ toxicity - single exposure (Category 3), Respiratory system, H335

For the full text of the H-Statements mentioned in this Section, see Section 16.

2.2 Label elements

Labelling according Regulation (EC) No 1272/2008 Pictogram

Signal word Danger

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Hazard statement(s) H225 Highly flammable liquid and vapour. H290 May be corrosive to metals. H301 + H311 + H331 Toxic if swallowed, in contact with skin or if inhaled H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation. H370 Causes damage to organs. Precautionary statement(s) P210 Keep away from heat, hot surfaces, sparks, open flames and other

ignition sources. No smoking. P280 Wear protective gloves/ protective clothing. P302 + P352 + P312 IF ON SKIN: Wash with plenty of water.Call a POISON CENTER/doctor if

you feel unwell. P304 + P340 + P311 IF INHALED: Remove person to fresh air and keep comfortable for

breathing. Call a POISON CENTER/doctor. P370 + P378 In case of fire: Use dry powder or dry sand to extinguish. P403 + P235 Store in a well-ventilated place. Keep cool. Supplemental Hazard Statements

none

2.3 Other hazards This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

SECTION 3: Composition/information on ingredients

3.2 Mixtures Synonyms : Hydrochloric acidsolution

Formula : HCl Molecular weight : 36.46 g/mol Hazardous ingredients according to Regulation (EC) No 1272/2008

Component Classification Concentration

Methanol

CAS-No. EC-No. Index-No. Registration number

67-56-1 200-659-6 603-001-00-X 01-2119433307-44-XXXX

Flam. Liq. 2; Acute Tox. 3; STOT SE 1; H225, H301, H331, H311, H370 Concentration limits: >= 10 %: STOT SE 1, H370; 3 - < 10 %: STOT SE 2, H371;

>= 80 - < 90 %

Hydrochloric acid

CAS-No. EC-No. Index-No. Registration number

7647-01-0 231-595-7 017-002-01-X 01-2119484862-27-XXXX

Met. Corr. 1; Skin Corr. 1B; STOT SE 3; H290, H314, H335 Concentration limits: >= 25 %: Skin Corr. 1B, H314; 10 - < 25 %: Skin Irrit. 2, H315; 10 - < 25 %: Eye Irrit. 2, H319; >= 10 %: STOT SE 3, H335; >= 0.1 %: Met. Corr. 1, H290;

>= 10 - < 20 %

For the full text of the H-Statements mentioned in this Section, see Section 16.

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SECTION 4: First aid measures

4.1 Description of first aid measures

General advice Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician.

In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

4.2 Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

4.3 Indication of any immediate medical attention and special treatment needed No data available

SECTION 5: Firefighting measures

5.1 Extinguishing media

Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

5.2 Special hazards arising from the substance or mixture Carbon oxides, Hydrogen chloride gas

5.3 Advice for firefighters Wear self-contained breathing apparatus for firefighting if necessary.

5.4 Further information Use water spray to cool unopened containers.

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures Wear respiratory protection. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to form explosive concentrations. Vapours can accumulate in low areas. For personal protection see section 8.

6.2 Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

6.3 Methods and materials for containment and cleaning up Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations (see section 13).

6.4 Reference to other sections For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling Avoid contact with skin and eyes. Avoid inhalation of vapour or mist. Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic charge.

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For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

Recommended storage temperature 2 - 8 °C Storage class (TRGS 510): Flammable liquids

7.3 Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

8.1 Control parameters

8.2 Exposure controls

Appropriate engineering controls Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product.

Personal protective equipment

Eye/face protection Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Full contact Material: butyl-rubber Minimum layer thickness: 0.3 mm Break through time: 480 min Material tested:Butoject® (KCL 897 / Aldrich Z677647, Size M) Splash contact Material: Nitrile rubber Minimum layer thickness: 0.11 mm Break through time: 30 min Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail [email protected], test method: EN374 If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industria situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario. Body Protection Complete suit protecting against chemicals, Flame retardant antistatic protective clothing., The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use (US) or type ABEK (EN 14387) respirator cartridges as a backup to enginee protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

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Control of environmental exposure Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties

a) Appearance Form: liquid

b) Odour No data available

c) Odour Threshold No data available

d) pH No data available

e) Melting point/freezing point

No data available

f) Initial boiling point and boiling range

No data available

g) Flash point 11 °C - closed cup

h) Evaporation rate No data available

i) Flammability (solid, gas) No data available

j) Upper/lower flammability or explosive limits

No data available

k) Vapour pressure No data available

l) Vapour density No data available

m) Relative density No data available

n) Water solubility No data available

o) Partition coefficient: n-octanol/water

No data available

p) Auto-ignition temperature

No data available

q) Decomposition temperature

No data available

r) Viscosity No data available

s) Explosive properties No data available

t) Oxidizing properties No data available

9.2 Other safety information No data available

SECTION 10: Stability and reactivity

10.1 Reactivity No data available

10.2 Chemical stability Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions No data available

10.4 Conditions to avoid Heat, flames and sparks.

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10.5 Incompatible materials Acids, Bases, Oxidizing agents, Alkali metals, Metals, Amines, Acid chlorides, Acid anhydrides, Reducing agents, permanganates, e.g. potassium permanganate, Fluorine, hexalithium disilicide

10.6 Hazardous decomposition products Hazardous decomposition products formed under fire conditions. - Carbon oxides, Hydrogen chloride gas Other decomposition products - No data available In the event of fire: see section 5

SECTION 11: Toxicological information

11.1 Information on toxicological effects

Acute toxicity No data available

Skin corrosion/irritation No data available

Serious eye damage/eye irritation No data available

Respiratory or skin sensitisation No data available

Germ cell mutagenicity No data available

Carcinogenicity

IARC: 3 - Group 3: Not classifiable as to its carcinogenicity to humans (Hydrochloric acid)

Reproductive toxicity No data available

Specific target organ toxicity - single exposure No data available

Specific target organ toxicity - repeated exposure No data available

Aspiration hazard No data available

Additional Information RTECS: Not available Methyl alcohol may be fatal or cause blindness if swallowed., Cannot be made non-poisonous., Material is extremely destructive to tissue of the mucous membranes and upper respiratory tract, eyes, and skin., spasm, inflammation and edema of the larynx, spasm, inflammation and edema of the bronchi, pneumonitis, pulmonary edema, burning sensation, Cough, wheezing, laryngitis, Shortness of breath

SECTION 12: Ecological information

12.1 Toxicity No data available

12.2 Persistence and degradability No data available

12.3 Bioaccumulative potential No data available

12.4 Mobility in soil No data available

12.5 Results of PBT and vPvB assessment This substance/mixture contains no components considered to be either persistent, bioaccumulative and

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toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

12.6 Other adverse effects No data available

SECTION 13: Disposal considerations

13.1 Waste treatment methods

Product Burn in a chemical incinerator equipped with an afterburner and scrubber b highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company.

Contaminated packaging Dispose of as unused product.

SECTION 14: Transport information

14.1 UN number ADR/RID: 3286 IMDG: 3286 IATA: 3286

14.2 UN proper shipping name ADR/RID: FLAMMABLE LIQUID, TOXIC, CORROSIVE, N.O.S. (Hydrochloric acid, Methanol) IMDG: FLAMMABLE LIQUID, TOXIC, CORROSIVE, N.O.S. (Hydrochloric acid, Methanol) IATA: Flammable liquid, toxic, corrosive, n.o.s. (Hydrochloric acid, Methanol)

14.3 Transport hazard class(es) ADR/RID: 3 (6.1, 8) IMDG: 3 (6.1, 8) IATA: 3 (6.1, 8)

14.4 Packaging group ADR/RID: II IMDG: II IATA: II

14.5 Environmental hazards ADR/RID: no IMDG Marine pollutant: no IATA: no

14.6 Special precautions for user No data available

SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

15.2 Chemical safety assessment For this product a chemical safety assessment was not carried out

SECTION 16: Other information

Full text of H-Statements referred to under sections 2 and 3.

H225 Highly flammable liquid and vapour. H290 May be corrosive to metals. H301 Toxic if swallowed. H301 + H311 + H331

Toxic if swallowed, in contact with skin or if inhaled

H311 Toxic in contact with skin. H314 Causes severe skin burns and eye damage. H315 Causes skin irritation. H319 Causes serious eye irritation. H331 Toxic if inhaled. H335 May cause respiratory irritation. H370 Causes damage to organs. H371 May cause damage to organs.

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Further information Copyright 2016 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

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Sigma-Aldrich - 69880 Page 1 of 8

SIGMA-ALDRICH sigma-aldrich.com SAFETY DATA SHEET

according to Regulation (EC) No. 1907/2006 Version 6.0 Revision Date 31.03.2016

Print Date 10.11.2016 GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifiers Product name : Morpholine

Product Number : 69880 Brand : Sigma-Aldrich Index-No. : 613-028-00-9 REACH No. : A registration number is not available for this substance as the substance

or its uses are exempted from registration, the annual tonnage does not require a registration or the registration is envisaged for a later registration deadline.

CAS-No. : 110-91-8

1.2 Relevant identified uses of the substance or mixture and uses advised against

Identified uses : Laboratory chemicals, Manufacture of substances

1.3 Details of the supplier of the safety data sheet

Company : Sigma-Aldrich Chemical Pvt Limited Industrial Area, Anekal Taluka Plot No 12, 12 Bommasandra - Jigani Link Road 560100 BANGALORE INDIA

1.4 Emergency telephone number

Emergency Phone # : +91 98802 05043

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture

Classification according to Regulation (EC) No 1272/2008 Flammable liquids (Category 3), H226 Acute toxicity, Oral (Category 4), H302 Acute toxicity, Inhalation (Category 3), H331 Acute toxicity, Dermal (Category 3), H311 Skin corrosion (Category 1A), H314

For the full text of the H-Statements mentioned in this Section, see Section 16.

2.2 Label elements

Labelling according Regulation (EC) No 1272/2008 Pictogram

Signal word Danger Hazard statement(s) H226 Flammable liquid and vapour. H302 Harmful if swallowed.

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H311 + H331 Toxic in contact with skin or if inhaled. H314 Causes severe skin burns and eye damage. Precautionary statement(s) P210 Keep away from heat, hot surfaces, sparks, open flames and other

ignition sources. No smoking. P280 Wear protective gloves/ protective clothing/ eye protection/ face

protection. P303 + P361 + P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing.

Rinse skin with water/shower. P304 + P340 + P310 IF INHALED: Remove person to fresh air and keep comfortable for

breathing. Immediately call a POISON CENTER/doctor. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove

contact lenses, if present and easy to do. Continue rinsing. P370 + P378 In case of fire: Use dry powder or dry sand to extinguish. Supplemental Hazard Statements

none

2.3 Other hazards This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

SECTION 3: Composition/information on ingredients

3.1 Substances Synonyms : Tetrahydro-1,4-oxazine

Formula : C4H9NO

Molecular weight : 87.12 g/mol CAS-No. : 110-91-8 EC-No. : 203-815-1 Index-No. : 613-028-00-9 Hazardous ingredients according to Regulation (EC) No 1272/2008

Component Classification Concentration

Morpholine

CAS-No. EC-No. Index-No.

110-91-8 203-815-1 613-028-00-9

Flam. Liq. 3; Acute Tox. 4; Acute Tox. 3; Skin Corr. 1A; H226, H302, H331, H311, H314

<= 100 %

For the full text of the H-Statements mentioned in this Section, see Section 16.

SECTION 4: First aid measures

4.1 Description of first aid measures

General advice Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact Take off contaminated clothing and shoes immediately. Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician.

In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

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4.2 Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

4.3 Indication of any immediate medical attention and special treatment needed No data available

SECTION 5: Firefighting measures

5.1 Extinguishing media

Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

5.2 Special hazards arising from the substance or mixture Carbon oxides, Nitrogen oxides (NOx)

5.3 Advice for firefighters Wear self-contained breathing apparatus for firefighting if necessary.

5.4 Further information Use water spray to cool unopened containers.

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures Wear respiratory protection. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to form explosive concentrations. Vapours can accumulate in low areas. For personal protection see section 8.

6.2 Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

6.3 Methods and materials for containment and cleaning up Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations (see section 13).

6.4 Reference to other sections For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling Avoid contact with skin and eyes. Avoid inhalation of vapour or mist. Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic charge. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

hygroscopic Storage class (TRGS 510): Flammable liquids

7.3 Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

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Sigma-Aldrich - 69880 Page 4 of 8

SECTION 8: Exposure controls/personal protection

8.1 Control parameters

8.2 Exposure controls

Appropriate engineering controls Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product.

Personal protective equipment

Eye/face protection Tightly fitting safety goggles. Faceshield (8-inch minimum). Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Full contact Material: butyl-rubber Minimum layer thickness: 0.3 mm Break through time: 480 min Material tested:Butoject® (KCL 897 / Aldrich Z677647, Size M) Splash contact Material: butyl-rubber Minimum layer thickness: 0.3 mm Break through time: 480 min Material tested:Butoject® (KCL 897 / Aldrich Z677647, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail [email protected], test method: EN374 If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industria situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario. Body Protection Complete suit protecting against chemicals, Flame retardant antistatic protective clothing., The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use (US) or type ABEK (EN 14387) respirator cartridges as a backup to enginee protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Control of environmental exposure Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties

a) Appearance Form: liquid Colour: colourless

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b) Odour unpleasant

c) Odour Threshold No data available

d) pH 10.6 at 5 g/l at 20 °C

e) Melting point/freezing point

Melting point/range: -7 - -5 °C - lit.

f) Initial boiling point and boiling range

129 °C - lit.

g) Flash point 31 °C - closed cup

h) Evaporation rate No data available

i) Flammability (solid, gas) No data available

j) Upper/lower flammability or explosive limits

Upper explosion limit: 10.8 %(V) Lower explosion limit: 1.8 %(V)

k) Vapour pressure 31 mmHg at 38 °C 7 mmHg at 20 °C

l) Vapour density 3.01 - (Air = 1.0)

m) Relative density 0.996 g/mL at 25 °C

n) Water solubility completely miscible

o) Partition coefficient: n-octanol/water

log Pow: -2.55 at 25 °C

p) Auto-ignition temperature

255 °C at 1,013 hPa

q) Decomposition temperature

No data available

r) Viscosity No data available

s) Explosive properties No data available

t) Oxidizing properties No data available

9.2 Other safety information

Relative vapour density 3.01 - (Air = 1.0)

SECTION 10: Stability and reactivity

10.1 Reactivity No data available

10.2 Chemical stability Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions No data available

10.4 Conditions to avoid Heat, flames and sparks.

10.5 Incompatible materials Strong oxidizing agents

10.6 Hazardous decomposition products Hazardous decomposition products formed under fire conditions. - Carbon oxides, Nitrogen oxides (NOx) Other decomposition products - No data available In the event of fire: see section 5

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Sigma-Aldrich - 69880 Page 6 of 8

SECTION 11: Toxicological information

11.1 Information on toxicological effects

Acute toxicity LD50 Oral - Rat - male and female - 1,900 mg/kg(Morpholine) (OECD Test Guideline 401) LD50 Dermal - Rabbit - male - 500 mg/kg(Morpholine) (OECD Test Guideline 402)

Skin corrosion/irritation Skin - Rabbit(Morpholine) Result: Causes severe burns. (OECD Test Guideline 404)

Serious eye damage/eye irritation Eyes - Rabbit(Morpholine) Result: Corrosive (OECD Test Guideline 405)

Respiratory or skin sensitisation Buehler Test - Guinea pig(Morpholine) Result: Did not cause sensitisation on laboratory animals.

Germ cell mutagenicity unscheduled DNA synthesis assay(Morpholine) rat hepatocytes Result: negative (Morpholine) Hamster - female Result: negative

Carcinogenicity

IARC: 3 - Group 3: Not classifiable as to its carcinogenicity to humans (Morpholine)

Reproductive toxicity

No data available(Morpholine)

Specific target organ toxicity - single exposure No data available(Morpholine)

Specific target organ toxicity - repeated exposure No data available

Aspiration hazard No data available(Morpholine)

Additional Information

Repeated dose toxicity - Rat - female - Oral - Lowest observed adverse effect level - 500 mg/kg(Morpholine) RTECS: QD6475000 Material is extremely destructive to tissue of the mucous membranes and upper respiratory tract, eyes, and skin., Cough, Shortness of breath, Headache, Nausea(Morpholine) To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.(Morpholine)

SECTION 12: Ecological information

12.1 Toxicity

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Sigma-Aldrich - 69880 Page 7 of 8

Toxicity to fish static test LC50 - Oncorhynchus mykiss (rainbow trout) - 380 mg/l - 96 h(Morpholine)

Toxicity to daphnia and other aquatic invertebrates

Immobilization EC50 - Daphnia magna (Water flea) - 45 mg/l - 48 h(Morpholine) (OECD Test Guideline 202)

Toxicity to algae static test EC50 - Pseudokirchneriella subcapitata - 28 mg/l - 96 h(Morpholine)

12.2 Persistence and degradability Biodegradability aerobic - Exposure time 25 d(Morpholine)

Result: 93 % - Readily biodegradable

12.3 Bioaccumulative potential Bioaccumulation Cyprinus carpio (Carp) - 0.5 mg/l(Morpholine)

Bioconcentration factor (BCF): < 2.8 (OECD Test Guideline 305C)

12.4 Mobility in soil No data available(Morpholine)

12.5 Results of PBT and vPvB assessment This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

12.6 Other adverse effects Harmful to aquatic life.

SECTION 13: Disposal considerations

13.1 Waste treatment methods

Product Burn in a chemical incinerator equipped with an afterburner and scrubber b highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company.

Contaminated packaging Dispose of as unused product.

SECTION 14: Transport information

14.1 UN number ADR/RID: 2054 IMDG: 2054 IATA: 2054

14.2 UN proper shipping name ADR/RID: MORPHOLINE IMDG: MORPHOLINE IATA: Morpholine

14.3 Transport hazard class(es) ADR/RID: 8 (3) IMDG: 8 (3) IATA: 8 (3)

14.4 Packaging group ADR/RID: I IMDG: I IATA: I

14.5 Environmental hazards ADR/RID: no IMDG Marine pollutant: no IATA: no

14.6 Special precautions for user No data available

SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

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15.2 Chemical safety assessment For this product a chemical safety assessment was not carried out

SECTION 16: Other information

Full text of H-Statements referred to under sections 2 and 3.

H226 Flammable liquid and vapour. H302 Harmful if swallowed. H311 Toxic in contact with skin. H311 + H331 Toxic in contact with skin or if inhaled. H314 Causes severe skin burns and eye damage. H331 Toxic if inhaled.

Further information Copyright 2016 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

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Sigma-Aldrich - 296090 Page 1 of 8

SIGMA-ALDRICH sigma-aldrich.com SAFETY DATA SHEET

according to Regulation (EC) No. 1907/2006 Version 6.0 Revision Date 30.03.2016

Print Date 10.11.2016 GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifiers Product name : Hexane

Product Number : 296090 Brand : Sigma-Aldrich Index-No. : 601-037-00-0 REACH No. : 01-2119480412-44-XXXX

CAS-No. : 110-54-3

1.2 Relevant identified uses of the substance or mixture and uses advised against

Identified uses : Laboratory chemicals, Manufacture of substances

1.3 Details of the supplier of the safety data sheet

Company : Sigma-Aldrich Chemical Pvt Limited Industrial Area, Anekal Taluka Plot No 12, 12 Bommasandra - Jigani Link Road 560100 BANGALORE INDIA

1.4 Emergency telephone number

Emergency Phone # : +91 98802 05043

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture

Classification according to Regulation (EC) No 1272/2008 Flammable liquids (Category 2), H225 Skin irritation (Category 2), H315 Reproductive toxicity (Category 2), H361f Specific target organ toxicity - single exposure (Category 3), Central nervous system, H336 Specific target organ toxicity - repeated exposure (Category 2), H373 Aspiration hazard (Category 1), H304 Chronic aquatic toxicity (Category 2), H411

For the full text of the H-Statements mentioned in this Section, see Section 16.

2.2 Label elements

Labelling according Regulation (EC) No 1272/2008 Pictogram

Signal word Danger Hazard statement(s) H225 Highly flammable liquid and vapour. H304 May be fatal if swallowed and enters airways. H315 Causes skin irritation.

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H336 May cause drowsiness or dizziness. H361f Suspected of damaging fertility. H373 May cause damage to organs through prolonged or repeated exposure. H411 Toxic to aquatic life with long lasting effects. Precautionary statement(s) P201 Obtain special instructions before use. P210 Keep away from heat, hot surfaces, sparks, open flames and other

ignition sources. No smoking. P273 Avoid release to the environment. P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor. P308 + P313 IF exposed or concerned: Get medical advice/ attention. P331 Do NOT induce vomiting. Supplemental Hazard Statements

none

2.3 Other hazards This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

SECTION 3: Composition/information on ingredients

3.1 Substances Synonyms : n-Hexane

Formula : C<SB>6</>H<SB>14</> Molecular weight : 86.18 g/mol CAS-No. : 110-54-3 EC-No. : 203-777-6 Index-No. : 601-037-00-0 Registration number : 01-2119480412-44-XXXX

Hazardous ingredients according to Regulation (EC) No 1272/2008

Component Classification Concentration

n-Hexane

CAS-No. EC-No. Index-No.

110-54-3 203-777-6 601-037-00-0

Flam. Liq. 2; Skin Irrit. 2; Repr. 2; STOT SE 3; STOT RE 2; Asp. Tox. 1; Aquatic Chronic 2; H225, H315, H361f, H336, H373, H304, H411 Concentration limits: >= 5 %: STOT RE 2, H373;

<= 100 %

For the full text of the H-Statements mentioned in this Section, see Section 16.

SECTION 4: First aid measures

4.1 Description of first aid measures

General advice Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact Wash off with soap and plenty of water. Consult a physician.

In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

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If swallowed Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

4.2 Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

4.3 Indication of any immediate medical attention and special treatment needed No data available

SECTION 5: Firefighting measures

5.1 Extinguishing media

Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

5.2 Special hazards arising from the substance or mixture Carbon oxides

5.3 Advice for firefighters Wear self-contained breathing apparatus for firefighting if necessary.

5.4 Further information Use water spray to cool unopened containers.

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures Use personal protective equipment. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to form explosive concentrations. Vapours can accumulate in low areas. For personal protection see section 8.

6.2 Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

6.3 Methods and materials for containment and cleaning up Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations (see section 13).

6.4 Reference to other sections For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling Avoid contact with skin and eyes. Avoid inhalation of vapour or mist. Flash back possible over considerable distance.Container explosion may occur under fire conditions.Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic charge. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Storage class (TRGS 510): Flammable liquids

7.3 Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

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SECTION 8: Exposure controls/personal protection

8.1 Control parameters

8.2 Exposure controls

Appropriate engineering controls Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

Personal protective equipment

Eye/face protection Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Full contact Material: Nitrile rubber Minimum layer thickness: 0.4 mm Break through time: 480 min Material tested:Camatril® (KCL 730 / Aldrich Z677442, Size M) Splash contact Material: Nitrile rubber Minimum layer thickness: 0.2 mm Break through time: 59 min Material tested:Dermatril® P (KCL 743 / Aldrich Z677388, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail [email protected], test method: EN374 If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industria situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario. Body Protection Complete suit protecting against chemicals, Flame retardant antistatic protective clothing., The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use (US) or type AXBEK (EN 14387) respirator cartridges as a backup to engine protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Control of environmental exposure Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties

a) Appearance Form: liquid Colour: colourless

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b) Odour No data available

c) Odour Threshold No data available

d) pH 7.0

e) Melting point/freezing point

Melting point/range: -95 °C

f) Initial boiling point and boiling range

69 °C

g) Flash point -25.99 °C - closed cup

h) Evaporation rate 15.8

i) Flammability (solid, gas) No data available

j) Upper/lower flammability or explosive limits

Upper explosion limit: 7.7 %(V) Lower explosion limit: 1.2 %(V)

k) Vapour pressure 256.0 mmHg at 37.7 °C 132.0 mmHg at 20.0 °C

l) Vapour density No data available

m) Relative density 0.659 g/mL at 25 °C

n) Water solubility insoluble

o) Partition coefficient: n-octanol/water

log Pow: 3.90 - 4.11

p) Auto-ignition temperature

234.0 °C

q) Decomposition temperature

No data available

r) Viscosity No data available

s) Explosive properties No data available

t) Oxidizing properties No data available

9.2 Other safety information No data available

SECTION 10: Stability and reactivity

10.1 Reactivity No data available

10.2 Chemical stability Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions No data available

10.4 Conditions to avoid Exposure to moisture may affect product quality. Heat, flames and sparks.

10.5 Incompatible materials Oxidizing agents

10.6 Hazardous decomposition products Other decomposition products - No data available Hazardous decomposition products formed under fire conditions. - Carbon oxides In the event of fire: see section 5

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Sigma-Aldrich - 296090 Page 6 of 8

SECTION 11: Toxicological information

11.1 Information on toxicological effects

Acute toxicity LD50 Oral - Rat - 25,000 mg/kg(n-Hexane) LC50 Inhalation - Rat - 4 h - 48000 ppm(n-Hexane)

Skin corrosion/irritation Irritating to skin.(n-Hexane)

Serious eye damage/eye irritation Eyes - Rabbit(n-Hexane) Result: Mild eye irritation

Respiratory or skin sensitisation No data available(n-Hexane)

Germ cell mutagenicity No data available(n-Hexane)

Carcinogenicity

IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.

Reproductive toxicity

Overexposure may cause reproductive disorder(s) based on tests with laboratory animals. Suspected human reproductive toxicant Suspected of damaging fertility.(n-Hexane)

Specific target organ toxicity - single exposure May cause drowsiness or dizziness.(n-Hexane)

Specific target organ toxicity - repeated exposure Ingestion - May cause damage to organs through prolonged or repeated exposure. - Nervous system

Aspiration hazard May be fatal if swallowed and enters airways.(n-Hexane)

Additional Information RTECS: MN9275000 Prolonged or repeated contact with skin may cause:, defatting, Dermatitis, Contact with eyes can cause:, Redness, Blurred vision, Provokes tears., Effects due to ingestion may include:, Gastrointestinal discomfort, Central nervous system depression, Lung irritation, chest pain, pulmonary edema, giddiness, slowed reaction time, slurred speech, Headache, Dizziness, Drowsiness, Unconsciousness(n-Hexane)

SECTION 12: Ecological information

12.1 Toxicity Toxicity to fish LC50 - Pimephales promelas (fathead minnow) - 2.5 mg/l - 96.0 h(n-Hexane) Toxicity to daphnia and other aquatic invertebrates

EC50 - Daphnia magna (Water flea) - 3,878.00 mg/l - 48 h(n-Hexane)

Toxicity to algae EC50 - Chlorella vulgaris (Fresh water algae) - 12,840.00 mg/l - 3 h(n-Hexane) EC50 - SKELETOMA - 0.30 mg/l - 8 h(n-Hexane)

12.2 Persistence and degradability No data available

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12.3 Bioaccumulative potential No data available

12.4 Mobility in soil No data available(n-Hexane)

12.5 Results of PBT and vPvB assessment This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

12.6 Other adverse effects Toxic to aquatic life with long lasting effects.

SECTION 13: Disposal considerations

13.1 Waste treatment methods

Product Burn in a chemical incinerator equipped with an afterburner and scrubber b highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company.

Contaminated packaging Dispose of as unused product.

SECTION 14: Transport information

14.1 UN number ADR/RID: 1208 IMDG: 1208 IATA: 1208

14.2 UN proper shipping name ADR/RID: HEXANES IMDG: HEXANES IATA: Hexanes

14.3 Transport hazard class(es) ADR/RID: 3 IMDG: 3 IATA: 3

14.4 Packaging group ADR/RID: II IMDG: II IATA: II

14.5 Environmental hazards ADR/RID: no IMDG Marine pollutant: no IATA: no

14.6 Special precautions for user No data available

SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

15.2 Chemical safety assessment For this product a chemical safety assessment was not carried out

SECTION 16: Other information

Full text of H-Statements referred to under sections 2 and 3.

H225 Highly flammable liquid and vapour. H304 May be fatal if swallowed and enters airways. H315 Causes skin irritation. H336 May cause drowsiness or dizziness. H361f Suspected of damaging fertility. H373 May cause damage to organs through prolonged or repeated exposure. H411 Toxic to aquatic life with long lasting effects.

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Sigma-Aldrich - 296090 Page 8 of 8

Further information Copyright 2016 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

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Sigma - M6762 Page 1 of 8

SIGMA-ALDRICH sigma-aldrich.com SAFETY DATA SHEET

according to Regulation (EC) No. 1907/2006 Version 6.0 Revision Date 03.04.2016

Print Date 10.11.2016 GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifiers Product name : 1-Methyl-2-pyrrolidinone

Product Number : M6762 Brand : Sigma Index-No. : 606-021-00-7 REACH No. : 01-2119472430-46-XXXX

CAS-No. : 872-50-4

1.2 Relevant identified uses of the substance or mixture and uses advised against

Identified uses : Laboratory chemicals, Manufacture of substances

1.3 Details of the supplier of the safety data sheet

Company : Sigma-Aldrich Chemical Pvt Limited Industrial Area, Anekal Taluka Plot No 12, 12 Bommasandra - Jigani Link Road 560100 BANGALORE INDIA

1.4 Emergency telephone number

Emergency Phone # : +91 98802 05043

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture

Classification according to Regulation (EC) No 1272/2008 Skin irritation (Category 2), H315 Eye irritation (Category 2), H319 Reproductive toxicity (Category 1B), H360D Specific target organ toxicity - single exposure (Category 3), Respiratory system, H335

For the full text of the H-Statements mentioned in this Section, see Section 16.

2.2 Label elements

Labelling according Regulation (EC) No 1272/2008 Pictogram

Signal word Danger Hazard statement(s) H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation. H360D May damage the unborn child.

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Precautionary statement(s) P201 Obtain special instructions before use. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove

contact lenses, if present and easy to do. Continue rinsing. P308 + P313 IF exposed or concerned: Get medical advice/ attention. Supplemental Hazard Statements

none

Restricted to professional users.

2.3 Other hazards This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

SECTION 3: Composition/information on ingredients

3.1 Substances Synonyms : N-Methyl-2-pyrrolidone

1-Methyl-2-pyrrolidone NMP M-PYROL™

Formula : C5H9NO

Molecular weight : 99.13 g/mol CAS-No. : 872-50-4 EC-No. : 212-828-1 Index-No. : 606-021-00-7 Registration number : 01-2119472430-46-XXXX

Hazardous ingredients according to Regulation (EC) No 1272/2008

Component Classification Concentration

N-methyl-2-pyrrolidone Included in the Candidate List of Substances of Very High Concern (SVHC) according to Regulation (EC) No. 1907/2006 (REACH)

CAS-No. EC-No. Index-No. Registration number

872-50-4 212-828-1 606-021-00-7 01-2119472430-46-XXXX

Skin Irrit. 2; Eye Irrit. 2; Repr. 1B; STOT SE 3; H315, H319, H360D, H335 Concentration limits: >= 5 %: Repr. 1B, H360D; >= 10 %: STOT SE 3, H335;

<= 100 %

For the full text of the H-Statements mentioned in this Section, see Section 16.

SECTION 4: First aid measures

4.1 Description of first aid measures

General advice Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact Wash off with soap and plenty of water. Consult a physician.

In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

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4.2 Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

4.3 Indication of any immediate medical attention and special treatment needed No data available

SECTION 5: Firefighting measures

5.1 Extinguishing media

Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

5.2 Special hazards arising from the substance or mixture Carbon oxides, Nitrogen oxides (NOx)

5.3 Advice for firefighters Wear self-contained breathing apparatus for firefighting if necessary.

5.4 Further information Use water spray to cool unopened containers.

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures Use personal protective equipment. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to form explosive concentrations. Vapours can accumulate in low areas. For personal protection see section 8.

6.2 Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

6.3 Methods and materials for containment and cleaning up Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations (see section 13). Keep in suitable, closed containers for disposal.

6.4 Reference to other sections For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling Avoid exposure - obtain special instructions before use.Avoid contact with skin and eyes. Avoid inhalation of vapour or mist. Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic charge. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

Store under inert gas. Moisture sensitive. Storage class (TRGS 510): Combustible liquids not in Storage Class 3

7.3 Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

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SECTION 8: Exposure controls/personal protection

8.1 Control parameters

Derived No Effect Level (DNEL)

Application Area Exposure routes

Health effect Value

Workers Skin contact Acute systemic effects 208mg/kg BW/d

Workers Inhalation Acute systemic effects 80 mg/m3

Workers Skin contact Long-term systemic effects 19.8mg/kg BW/d

Workers Inhalation Long-term systemic effects 40 mg/m3

Predicted No Effect Concentration (PNEC)

Compartment Value

Water 5 mg/l

Soil 0.138 mg/kg

Marine water 0.025 mg/kg

Fresh water 0.25 mg/l

Fresh water sediment 0.805 mg/kg

Onsite sewage treatment plant 10 mg/l

8.2 Exposure controls

Appropriate engineering controls Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

Personal protective equipment

Eye/face protection Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Full contact Material: butyl-rubber Minimum layer thickness: 0.3 mm Break through time: 480 min Material tested:Butoject® (KCL 897 / Aldrich Z677647, Size M) Splash contact Material: Nature latex/chloroprene Minimum layer thickness: 0.6 mm Break through time: 35 min Material tested:Lapren® (KCL 706 / Aldrich Z677558, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail [email protected], test method: EN374 If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industria situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario.

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Body Protection Impervious clothing, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use (US) or type ABEK (EN 14387) respirator cartridges as a backup to enginee protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Control of environmental exposure Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties

a) Appearance Form: liquid Colour: colourless

b) Odour No data available

c) Odour Threshold No data available

d) pH 7.7 - 8

e) Melting point/freezing point

-23.99 °C

f) Initial boiling point and boiling range

202 °C at 1013 hPa 81 - 82 °C at 13 hPa

g) Flash point 91 °C - closed cup

h) Evaporation rate No data available

i) Flammability (solid, gas) No data available

j) Upper/lower flammability or explosive limits

Upper explosion limit: 9.5 %(V) Lower explosion limit: 1.3 %(V)

k) Vapour pressure 0.29 - 0.32 mmHg at 20 °C 0.99 mmHg at 40 °C

l) Vapour density 3.42 - (Air = 1.0)

m) Relative density 1.028 g/cm3

n) Water solubility No data available

o) Partition coefficient: n-octanol/water

log Pow: -0.46

p) Auto-ignition temperature

No data available

q) Decomposition temperature

No data available

r) Viscosity No data available

s) Explosive properties No data available

t) Oxidizing properties No data available

9.2 Other safety information

Surface tension 40.7 mN/m

Relative vapour density 3.42 - (Air = 1.0)

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SECTION 10: Stability and reactivity

10.1 Reactivity No data available

10.2 Chemical stability Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions No data available

10.4 Conditions to avoid Heat, flames and sparks.

10.5 Incompatible materials Strong acids, Strong oxidizing agents, Strong reducing agents

10.6 Hazardous decomposition products Hazardous decomposition products formed under fire conditions. - Carbon oxides, Nitrogen oxides (NOx) Other decomposition products - No data available In the event of fire: see section 5

SECTION 11: Toxicological information

11.1 Information on toxicological effects

Acute toxicity LD50 Oral - Rat - 3,914 mg/kg(N-methyl-2-pyrrolidone) LDLO Inhalation - Rat - 4 h - > 5100 ppm(N-methyl-2-pyrrolidone) LD50 Dermal - Rabbit - 8,000 mg/kg(N-methyl-2-pyrrolidone)

Skin corrosion/irritation Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)(N-methyl-2-pyrrolidone)

Serious eye damage/eye irritation Eyes - Rabbit(N-methyl-2-pyrrolidone) Result: Eye irritation

Respiratory or skin sensitisation No data available(N-methyl-2-pyrrolidone)

Germ cell mutagenicity No data available(N-methyl-2-pyrrolidone)

Carcinogenicity

IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.

Reproductive toxicity Damage to fetus possible(N-methyl-2-pyrrolidone)

Specific target organ toxicity - single exposure Inhalation - May cause respiratory irritation.(N-methyl-2-pyrrolidone)

Specific target organ toxicity - repeated exposure No data available

Aspiration hazard No data available(N-methyl-2-pyrrolidone)

Additional Information RTECS: UY5790000

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prolonged or repeated exposure can cause:, Vomiting, Diarrhoea, Abdominal pain, Rats exposed to 1-methyl-2-pyrrolidinone at a concentration of 1 mg/L as a cells in the bone marrow and atrophy of the lymphoid tissues of the thymu(N-methyl-2-pyrrolidone) Bone marrow - Irregularities - Based on Human Evidence(N-methyl-2-pyrrolidone)

SECTION 12: Ecological information

12.1 Toxicity Toxicity to fish LC50 - other fish - 4,000 mg/l - 96 h(N-methyl-2-pyrrolidone) LC50 - Leuciscus idus (Golden orfe) - > 500 mg/l - 96 h(N-methyl-2-

pyrrolidone) Toxicity to daphnia and other aquatic invertebrates

EC50 - Daphnia magna (Water flea) - > 1,000 mg/l - 24 h(N-methyl-2-pyrrolidone)

Toxicity to bacteria LC50 - Bacteria - > 9,000 mg/l (N-methyl-2-pyrrolidone)

12.2 Persistence and degradability Biodegradability Result: 90 % - Readily biodegradable

12.3 Bioaccumulative potential No data available

12.4 Mobility in soil No data available(N-methyl-2-pyrrolidone)

12.5 Results of PBT and vPvB assessment This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

12.6 Other adverse effects No data available

SECTION 13: Disposal considerations

13.1 Waste treatment methods

Product This combustible material may be burned in a chemical incinerator equipped with an afterburner and scrubber. Offer surplus and non-recyclable solutions to a licensed disposal company.

Contaminated packaging Dispose of as unused product.

SECTION 14: Transport information

14.1 UN number ADR/RID: - IMDG: - IATA: -

14.2 UN proper shipping name ADR/RID: Not dangerous goods IMDG: Not dangerous goods IATA: Not dangerous goods

14.3 Transport hazard class(es) ADR/RID: - IMDG: - IATA: -

14.4 Packaging group ADR/RID: - IMDG: - IATA: -

14.5 Environmental hazards ADR/RID: no IMDG Marine pollutant: no IATA: no

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14.6 Special precautions for user No data available

SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

Authorisations and/or restrictions on use 15.2 Chemical safety assessment

A Chemical Safety Assessment has been carried out for this substance.

SECTION 16: Other information

Full text of H-Statements referred to under sections 2 and 3.

H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation. H360D May damage the unborn child.

Further information Copyright 2016 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

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SIGMA-ALDRICH sigma-aldrich.com SAFETY DATA SHEET

according to Regulation (EC) No. 1907/2006 Version 6.0 Revision Date 31.03.2016

Print Date 10.11.2016 GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifiers Product name : 1-Methylpiperazine

Product Number : 130001 Brand : Aldrich REACH No. : A registration number is not available for this substance as the substance

or its uses are exempted from registration, the annual tonnage does not require a registration or the registration is envisaged for a later registration deadline.

CAS-No. : 109-01-3

1.2 Relevant identified uses of the substance or mixture and uses advised against

Identified uses : Laboratory chemicals, Manufacture of substances

1.3 Details of the supplier of the safety data sheet

Company : Sigma-Aldrich Chemical Pvt Limited Industrial Area, Anekal Taluka Plot No 12, 12 Bommasandra - Jigani Link Road 560100 BANGALORE INDIA

1.4 Emergency telephone number

Emergency Phone # : +91 98802 05043

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture

Classification according to Regulation (EC) No 1272/2008 Flammable liquids (Category 3), H226 Acute toxicity, Inhalation (Category 3), H331 Acute toxicity, Dermal (Category 4), H312 Skin corrosion (Category 1B), H314

For the full text of the H-Statements mentioned in this Section, see Section 16.

2.2 Label elements

Labelling according Regulation (EC) No 1272/2008 Pictogram

Signal word Danger Hazard statement(s) H226 Flammable liquid and vapour. H312 Harmful in contact with skin. H314 Causes severe skin burns and eye damage. H331 Toxic if inhaled.

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Precautionary statement(s) P261 Avoid breathing vapours. P280 Wear protective gloves/ protective clothing/ eye protection/ face

protection. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove

contact lenses, if present and easy to do. Continue rinsing. P310 Immediately call a POISON CENTER/doctor. Supplemental Hazard Statements

none

2.3 Other hazards This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

SECTION 3: Composition/information on ingredients

3.1 Substances Formula : C5H12N2

Molecular weight : 100.16 g/mol CAS-No. : 109-01-3 EC-No. : 203-639-5 Hazardous ingredients according to Regulation (EC) No 1272/2008

Component Classification Concentration

1-Methylpiperazine

CAS-No. EC-No.

109-01-3 203-639-5

Flam. Liq. 3; Acute Tox. 3; Acute Tox. 4; Skin Corr. 1B; H226, H331, H312, H314

<= 100 %

For the full text of the H-Statements mentioned in this Section, see Section 16.

SECTION 4: First aid measures

4.1 Description of first aid measures

General advice Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact Take off contaminated clothing and shoes immediately. Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician.

In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

4.2 Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

4.3 Indication of any immediate medical attention and special treatment needed No data available

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SECTION 5: Firefighting measures

5.1 Extinguishing media

Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

5.2 Special hazards arising from the substance or mixture Carbon oxides, Nitrogen oxides (NOx)

5.3 Advice for firefighters Wear self-contained breathing apparatus for firefighting if necessary.

5.4 Further information Use water spray to cool unopened containers.

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures Wear respiratory protection. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to form explosive concentrations. Vapours can accumulate in low areas. For personal protection see section 8.

6.2 Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

6.3 Methods and materials for containment and cleaning up Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations (see section 13).

6.4 Reference to other sections For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling Avoid contact with skin and eyes. Avoid inhalation of vapour or mist. Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic charge. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

hygroscopic Moisture sensitive. Storage class (TRGS 510): Flammable liquids

7.3 Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

8.1 Control parameters

8.2 Exposure controls

Appropriate engineering controls Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product.

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Personal protective equipment

Eye/face protection Tightly fitting safety goggles. Faceshield (8-inch minimum). Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Full contact Material: butyl-rubber Minimum layer thickness: 0.3 mm Break through time: 480 min Material tested:Butoject® (KCL 897 / Aldrich Z677647, Size M) Splash contact Material: Nitrile rubber Minimum layer thickness: 0.4 mm Break through time: 240 min Material tested:Camatril® (KCL 730 / Aldrich Z677442, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail [email protected], test method: EN374 If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industria situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario. Body Protection Complete suit protecting against chemicals, Flame retardant antistatic protective clothing., The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use (US) or type ABEK (EN 14387) respirator cartridges as a backup to enginee protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Control of environmental exposure Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties

a) Appearance Form: clear, liquid Colour: light yellow

b) Odour No data available

c) Odour Threshold No data available

d) pH No data available

e) Melting point/freezing point

No data available

f) Initial boiling point and boiling range

138 °C - lit.

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g) Flash point 39 °C - closed cup

h) Evaporation rate No data available

i) Flammability (solid, gas) No data available

j) Upper/lower flammability or explosive limits

No data available

k) Vapour pressure No data available

l) Vapour density 3.46 - (Air = 1.0)

m) Relative density 0.903 g/cm3 at 25 °C

n) Water solubility No data available

o) Partition coefficient: n-octanol/water

No data available

p) Auto-ignition temperature

No data available

q) Decomposition temperature

No data available

r) Viscosity No data available

s) Explosive properties No data available

t) Oxidizing properties No data available

9.2 Other safety information

Relative vapour density 3.46 - (Air = 1.0)

SECTION 10: Stability and reactivity

10.1 Reactivity No data available

10.2 Chemical stability Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions No data available

10.4 Conditions to avoid Heat, flames and sparks.

10.5 Incompatible materials Acids, Acid chlorides, Acid anhydrides, Strong oxidizing agents, Carbon dioxide (CO2)

10.6 Hazardous decomposition products Hazardous decomposition products formed under fire conditions. - Carbon oxides, Nitrogen oxides (NOx) Other decomposition products - No data available In the event of fire: see section 5

SECTION 11: Toxicological information

11.1 Information on toxicological effects

Acute toxicity LD50 Oral - Rat - 2,553 mg/kg(1-Methylpiperazine) LC50 Inhalation - Mouse - 2 h - 2.7 mg/l(1-Methylpiperazine) Remarks: Behavioral:Excitement. Lungs, Thorax, or Respiration:Dyspnea.

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LD50 Dermal - Rabbit - 1,344 mg/kg(1-Methylpiperazine) LD50 Intraperitoneal - Mouse - 150 mg/kg(1-Methylpiperazine)

Skin corrosion/irritation Skin - Rabbit(1-Methylpiperazine) Result: Severe skin irritation

Serious eye damage/eye irritation Eyes - Rabbit(1-Methylpiperazine) Result: Severe eye irritation

Respiratory or skin sensitisation No data available(1-Methylpiperazine)

Germ cell mutagenicity No data available(1-Methylpiperazine)

Carcinogenicity

IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.

Reproductive toxicity No data available(1-Methylpiperazine)

Specific target organ toxicity - single exposure No data available(1-Methylpiperazine)

Specific target organ toxicity - repeated exposure No data available

Aspiration hazard No data available(1-Methylpiperazine)

Additional Information RTECS: TM1225000 Material is extremely destructive to tissue of the mucous membranes and upper respiratory tract, eyes, and skin., Aspiration or inhalation may cause chemical pneumonitis., spasm, inflammation and edema of the bronchi, Acute symptoms of overexposure include:, burning sensation, Cough, wheezing, laryngitis, Headache, Nausea, Vomiting(1-Methylpiperazine)

SECTION 12: Ecological information

12.1 Toxicity No data available

12.2 Persistence and degradability No data available

12.3 Bioaccumulative potential No data available

12.4 Mobility in soil No data available(1-Methylpiperazine)

12.5 Results of PBT and vPvB assessment This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

12.6 Other adverse effects No data available

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SECTION 13: Disposal considerations

13.1 Waste treatment methods

Product Burn in a chemical incinerator equipped with an afterburner and scrubber b highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company.

Contaminated packaging Dispose of as unused product.

SECTION 14: Transport information

14.1 UN number ADR/RID: 2734 IMDG: 2734 IATA: 2734

14.2 UN proper shipping name ADR/RID: AMINES, LIQUID, CORROSIVE, FLAMMABLE, N.O.S. (1-Methylpiperazine) IMDG: AMINES, LIQUID, CORROSIVE, FLAMMABLE, N.O.S. (1-Methylpiperazine) IATA: Amines, liquid, corrosive, flammable, n.o.s. (1-Methylpiperazine)

14.3 Transport hazard class(es) ADR/RID: 8 (3) IMDG: 8 (3) IATA: 8 (3)

14.4 Packaging group ADR/RID: II IMDG: II IATA: II

14.5 Environmental hazards ADR/RID: no IMDG Marine pollutant: no IATA: no

14.6 Special precautions for user No data available

SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

15.2 Chemical safety assessment For this product a chemical safety assessment was not carried out

SECTION 16: Other information

Full text of H-Statements referred to under sections 2 and 3.

H226 Flammable liquid and vapour. H312 Harmful in contact with skin. H314 Causes severe skin burns and eye damage. H331 Toxic if inhaled.

Further information Copyright 2016 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

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SAFETY DATA SHEET

1. IdentificationProduct Name 1-Chloro-3-nitrobenzene

Cat No. : AC203990000; AC203990010; AC203990050; AC203992500

Synonyms M-Nitrochlorobenzene; M-Chloronitrobenzene

Recommended Use Laboratory chemicals.

Uses advised against No Information available

Details of the supplier of the safety data sheet

2. Hazard(s) identificationClassification This chemical is considered hazardous by the 2012 OSHA Hazard Communication Standard (29 CFR 1910.1200)

Label Elements

Signal WordDanger

Hazard StatementsToxic if swallowedToxic in contact with skinToxic if inhaled

Precautionary Statements

Prevention

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CompanyFisher ScientificOne Reagent LaneFair Lawn, NJ 07410Tel: (201) 796-7100

Acute dermal toxicity Category 3

Revision Date 28-May-2015

Acute Inhalation Toxicity - Dusts and Mists Category 3

Entity / Business NameAcros OrganicsOne Reagent LaneFair Lawn, NJ 07410

Emergency Telephone NumberFor information US call: 001-800-ACROS-01

/ Europe call: +32 14 57 52 11

Emergency Number US:001-201-796-7100 /

Europe: +32 14 57 52 99

CHEMTREC Tel. No.US:001-800-424-9300 /

Europe:001-703-527-3887

Revision Number 2Creation Date 22-Sep-2009

Acute oral toxicity Category 3

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Wash face, hands and any exposed skin thoroughly after handlingDo not eat, drink or smoke when using this productWear protective gloves/protective clothing/eye protection/face protectionAvoid breathing dust/fume/gas/mist/vapors/sprayUse only outdoors or in a well-ventilated area

InhalationIF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathingCall a POISON CENTER or doctor/physician

SkinIF ON SKIN: Wash with plenty of soap and waterCall a POISON CENTER or doctor/physician if you feel unwellRemove/Take off immediately all contaminated clothingWash contaminated clothing before reuse

IngestionIF SWALLOWED: Immediately call a POISON CENTER or doctor/physicianRinse mouth

StorageStore locked upStore in a well-ventilated place. Keep container tightly closed

DisposalDispose of contents/container to an approved waste disposal plant

Hazards not otherwise classified (HNOC) Toxic to aquatic life with long lasting effects

3. Composition / information on ingredients

Component CAS-No Weight %

m-Nitrochlorobenzene 121-73-3 98

4. First-aid measures

Eye Contact Immediate medical attention is required. Rinse immediately with plenty of water, also underthe eyelids, for at least 15 minutes.

Skin Contact Wash off immediately with plenty of water for at least 15 minutes. Immediate medicalattention is required.

Inhalation Move to fresh air. If breathing is difficult, give oxygen. Immediate medical attention isrequired.

Ingestion Do not induce vomiting. Call a physician or Poison Control Center immediately.

Most important symptoms/effects No information available.

Notes to Physician Treat symptomatically

5. Fire-fighting measuresSuitable Extinguishing Media Water spray. Carbon dioxide (CO 2). Dry chemical. chemical foam.

Unsuitable Extinguishing Media No information available

Flash Point 103 °C / 217.4 °F

Method - No information available

Autoignition Temperature 450 °C / 842 °F

Explosion Limits

Upper No data available

Lower No data available

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Sensitivity to Mechanical Impact No information available

Sensitivity to Static Discharge No information available

Specific Hazards Arising from the ChemicalKeep product and empty container away from heat and sources of ignition.

Hazardous Combustion ProductsHydrogen chloride gas Nitrogen oxides (NOx) Carbon monoxide (CO) Carbon dioxide (CO2)

Protective Equipment and Precautions for FirefightersAs in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and fullprotective gear.

NFPA

6. Accidental release measuresPersonal Precautions Ensure adequate ventilation. Use personal protective equipment.

Environmental Precautions See Section 12 for additional ecological information.

Methods for Containment and CleanUp

Sweep up or vacuum up spillage and collect in suitable container for disposal.

7. Handling and storageHandling Ensure adequate ventilation. Wear personal protective equipment. Avoid contact with skin,

eyes and clothing. Avoid dust formation. Avoid breathing dust/fume/gas/mist/vapours/spray.Avoid ingestion and inhalation.

Storage Keep in a dry, cool and well-ventilated place. Keep container tightly closed.

8. Exposure controls / personal protectionExposure Guidelines This product does not contain any hazardous materials with occupational exposure limits

established by the region specific regulatory bodies.

9. Physical and chemical propertiesPhysical State Solid

Appearance Dark yellow

Odor Odorless

Odor Threshold No information available

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Health3

Respiratory Protection Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European StandardEN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator ifexposure limits are exceeded or if irritation or other symptoms are experienced.

Engineering Measures Ensure adequate ventilation, especially in confined areas. Ensure that eyewash stationsand safety showers are close to the workstation location.

1-Chloro-3-nitrobenzene

Hygiene Measures Handle in accordance with good industrial hygiene and safety practice.

Flammability0

Revision Date 28-May-2015

Personal Protective Equipment

Instability0

Physical hazardsN/A

Eye/face Protection Wear appropriate protective eyeglasses or chemical safety goggles as described byOSHA's eye and face protection regulations in 29 CFR 1910.133 or European StandardEN166.

Skin and body protection Wear appropriate protective gloves and clothing to prevent skin exposure.

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pH No information available

Melting Point/Range 41 - 45 °C / 105.8 - 113 °F

Boiling Point/Range 236 °C / 456.8 °F @ 760 mmHg

Flash Point 103 °C / 217.4 °F

Evaporation Rate No information available

Flammability (solid,gas) No information available

Flammability or explosive limitsUpper No data available

Lower No data available

Vapor Pressure No information available

Vapor Density No information available

Relative Density 1.530

Solubility No information available

Partition coefficient; n-octanol/water No data available

Autoignition Temperature 450 °C / 842 °F

Decomposition Temperature No information available

Viscosity No information available

Molecular Formula C6 H4 Cl N O2

Molecular Weight 157.56

10. Stability and reactivity

Reactive Hazard None known, based on information available

Stability Stable under normal conditions.

Conditions to Avoid Incompatible products.

Incompatible Materials Strong oxidizing agents

Hazardous Decomposition Products Hydrogen chloride gas, Nitrogen oxides (NOx), Carbon monoxide (CO), Carbon dioxide(CO2)

Hazardous Polymerization Hazardous polymerization does not occur.

Hazardous Reactions None under normal processing.

11. Toxicological informationAcute Toxicity

Component InformationComponent LD50 Oral LD50 Dermal LC50 Inhalation

m-Nitrochlorobenzene 300 mg/kg ( Rat ) 800 mg/kg ( Rat ) Not listed

Toxicologically SynergisticProducts

No information available

Delayed and immediate effects as well as chronic effects from short and long-term exposure

Irritation No information available

Sensitization No information available

Carcinogenicity The table below indicates whether each agency has listed any ingredient as a carcinogen.

Component CAS-No IARC NTP ACGIH OSHA Mexico

m-Nitrochlorobenzene 121-73-3 Not listed Not listed Not listed Not listed Not listed

Mutagenic Effects No information available

Reproductive Effects No information available.

Developmental Effects No information available.

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Teratogenicity No information available.

STOT - single exposure None known

STOT - repeated exposure None known

Aspiration hazard No information available

Symptoms / effects,both acute anddelayed

No information available

Endocrine Disruptor Information No information available

Other Adverse Effects The toxicological properties have not been fully investigated.

12. Ecological informationEcotoxicity Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. Do not flush into surface water orsanitary sewer system. Do not allow material to contaminate ground water system. Do not empty into drains.

Component Freshwater Algae Freshwater Fish Microtox Water Flea

m-Nitrochlorobenzene 5.2 mg/L EC50 = 48 h 25 mg/L LC50 96 h 1.2 mg/LLC50 96 h 17.7 - 18.3 mg/L

LC50 96 h

EC50 = 15.0 mg/L 5 minEC50 = 17.3 mg/L 15 minEC50 = 19.8 mg/L 30 min

4.5 mg/L EC50 = 48 h

Persistence and Degradability No information available

Bioaccumulation/ Accumulation No information available.

Mobility .

Component log Pow

m-Nitrochlorobenzene 2.41

13. Disposal considerationsWaste Disposal Methods Chemical waste generators must determine whether a discarded chemical is classified as a

hazardous waste. Chemical waste generators must also consult local, regional, andnational hazardous waste regulations to ensure complete and accurate classification.

14. Transport informationDOT

UN-No UN1578

Proper Shipping Name CHLORONITROBENZENES, SOLID

Proper technical name (1-CHLORO-3-NITROBENZENE)

Hazard Class 6.1

Packing Group II

TDG

UN-No UN1578

Proper Shipping Name CHLORONITROBENZENES, SOLID

Hazard Class 6.1

Packing Group II

IATA

UN-No 1578

Proper Shipping Name CHLORONITROBENZENES, SOLID

Hazard Class 6.1

Packing Group II

IMDG/IMO

UN-No 1578

Proper Shipping Name CHLORONITROBENZENES, SOLID

Hazard Class 6.1

Packing Group II

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15. Regulatory information

International Inventories

Component TSCA DSL NDSL EINECS ELINCS NLP PICCS ENCS AICS IECSC KECL

m-Nitrochlorobenzene X - X 204-496-1 - X X X X -Legend:X - ListedE - Indicates a substance that is the subject of a Section 5(e) Consent order under TSCA.F - Indicates a substance that is the subject of a Section 5(f) Rule under TSCA.N - Indicates a polymeric substance containing no free-radical initiator in its inventory name but is considered to cover the designatedpolymer made with any free-radical initiator regardless of the amount used.P - Indicates a commenced PMN substanceR - Indicates a substance that is the subject of a Section 6 risk management rule under TSCA.S - Indicates a substance that is identified in a proposed or final Significant New Use RuleT - Indicates a substance that is the subject of a Section 4 test rule under TSCA.XU - Indicates a substance exempt from reporting under the Inventory Update Rule, i.e. Partial Updating of the TSCA Inventory Data BaseProduction and Site Reports (40 CFR 710(B).Y1 - Indicates an exempt polymer that has a number-average molecular weight of 1,000 or greater.Y2 - Indicates an exempt polymer that is a polyester and is made only from reactants included in a specified list of low concern reactantsthat comprises one of the eligibility criteria for the exemption rule.

U.S. Federal Regulations

TSCA 12(b) Not applicable

SARA 313 Not applicable

SARA 311/312 Hazardous CategorizationAcute Health Hazard Yes

Chronic Health Hazard No

Fire Hazard No

Sudden Release of Pressure Hazard No

Reactive Hazard No

Clean Water Act Not applicable

Clean Air Act Not applicable

OSHA Occupational Safety and Health AdministrationNot applicable

CERCLANot applicable

California Proposition 65 This product does not contain any Proposition 65 chemicals

State Right-to-Know

Component Massachusetts New Jersey Pennsylvania Illinois Rhode Island

m-Nitrochlorobenzene X - X - X

U.S. Department of Transportation

Reportable Quantity (RQ): NDOT Marine Pollutant NDOT Severe Marine Pollutant N

U.S. Department of Homeland SecurityThis product does not contain any DHS chemicals.

Other International Regulations

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1-Chloro-3-nitrobenzene Revision Date 28-May-2015

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Mexico - Grade No information available

CanadaThis product has been classified in accordance with the hazard criteria of the Controlled Products Regulations (CPR) andthe MSDS contains all the information required by the CPR

WHMIS Hazard Class D1A Very toxic materials

16. Other informationPrepared By Regulatory Affairs

Thermo Fisher ScientificEmail: [email protected]

Creation Date 22-Sep-2009

Revision Date 28-May-2015

Print Date 28-May-2015

Revision Summary This document has been updated to comply with the US OSHA HazCom 2012 Standardreplacing the current legislation under 29 CFR 1910.1200 to align with the GloballyHarmonized System of Classification and Labeling of Chemicals (GHS)

DisclaimerThe information provided on this Safety Data Sheet is correct to the best of our knowledge, information and belief at thedate of its publication. The information given is designed only as a guide for safe handling, use, processing, storage,transportation, disposal and release and is not to be considered as a warranty or quality specification. The informationrelates only to the specific material designated and may not be valid for such material used in combination with any othermaterial or in any process, unless specified in the text.

End of SDS

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3 2 0

He a lt h

Fire

Re a c t iv it y

Pe rs o n a lPro t e c t io n

2

3

0

H

Material Safety Data Sheeto-Xylene MSDS

Section 1: Chemical Product and Company Identification

Product Name: o-Xylene

Catalog Codes: SLX1012

CAS#: 95-47-6

RTECS: ZE2450000

TSCA: TSCA 8(b) inventory: o-Xylene

CI#: Not applicable.

Synonym: 1,2-Dimethylbenzene

Chemical Name: o-Xylene

Chemical Formula: C6H4(CH3)2

Contact Information:

Sciencelab.com, Inc.14025 Smith Rd.Houston, Texas 77396

US Sales: 1-800-901-7247International Sales: 1-281-441-4400

Order Online: ScienceLab.com

CHEMTREC (24HR Emergency Telephone), call:1-800-424-9300

International CHEMTREC, call: 1-703-527-3887

For non-emergency assistance, call: 1-281-441-4400

Section 2: Composition and Information on Ingredients

Composition:

Name CAS # % by Weight

{o-}Xylene 95-47-6 100

Toxicological Data on Ingredients: o-Xylene LD50: Not available. LC50: Not available.

Section 3: Hazards Identification

Potential Acute Health Effects: Hazardous in case of skin contact (irritant, permeator), of eye contact (irritant), of ingestion,of inhalation.

Potential Chronic Health Effects:CARCINOGENIC EFFECTS: A4 (Not classifiable for human or animal.) by ACGIH, 3 (Not classifiable for human.) by IARC.MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS: Classified POSSIBLE for human. DEVELOPMENTALTOXICITY: Classified Reproductive system/toxin/male [POSSIBLE]. The substance may be toxic to kidneys, liver, upperrespiratory tract, skin, eyes, central nervous system (CNS). Repeated or prolonged exposure to the substance can producetarget organs damage.

Section 4: First Aid Measures

Eye Contact:

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Check for and remove any contact lenses. Immediately flush eyes with running water for at least 15 minutes, keeping eyelidsopen. Get medical attention.

Skin Contact:In case of contact, immediately flush skin with plenty of water. Cover the irritated skin with an emollient. Remove contaminatedclothing and shoes. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention.

Serious Skin Contact:Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek immediate medicalattention.

Inhalation:If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medicalattention.

Serious Inhalation:Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or waistband. Ifbreathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth resuscitation. WARNING: It maybe hazardous to the person providing aid to give mouth-to-mouth resuscitation when the inhaled material is toxic, infectious orcorrosive. Seek medical attention.

Ingestion:Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconsciousperson. If large quantities of this material are swallowed, call a physician immediately. Loosen tight clothing such as a collar,tie, belt or waistband.

Serious Ingestion: Not available.

Section 5: Fire and Explosion Data

Flammability of the Product: Flammable.

Auto-Ignition Temperature: 463°C (865.4°F)

Flash Points: CLOSED CUP: 17°C (62.6°F).

Flammable Limits: LOWER: 0.9% UPPER: 6.7%

Products of Combustion: These products are carbon oxides (CO, CO2).

Fire Hazards in Presence of Various Substances: Highly flammable in presence of open flames and sparks, of heat.

Explosion Hazards in Presence of Various Substances:Risks of explosion of the product in presence of mechanical impact: Not available. Slightly explosive in presence of openflames and sparks, of heat.

Fire Fighting Media and Instructions:Flammable liquid, insoluble in water. SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use water spray or fog.

Special Remarks on Fire Hazards:Vapors are heavier than air and may travel considerable distance to source of ignition and flash back. When heated todecomposition it emits acrid smoke and irritating fumes.

Special Remarks on Explosion Hazards:Explosive in the form of vapor when exposed to heat or flame. Vapors may form explosive mixtures with air. Containers mayexplode when heated. Runoff to sewer may create fire or explosion hazard

Section 6: Accidental Release Measures

Small Spill: Absorb with an inert material and put the spilled material in an appropriate waste disposal.

Large Spill:

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Toxic flammable liquid, insoluble or very slightly soluble in water. Keep away from heat. Keep away from sources of ignition.Stop leak if without risk. Absorb with DRY earth, sand or other non-combustible material. Do not get water inside container.Do not touch spilled material. Prevent entry into sewers, basements or confined areas; dike if needed. Call for assistance ondisposal. Be careful that the product is not present at a concentration level above TLV. Check TLV on the MSDS and with localauthorities.

Section 7: Handling and Storage

Precautions:Keep locked up.. Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Donot ingest. Do not breathe gas/fumes/ vapor/spray. Wear suitable protective clothing. In case of insufficient ventilation, wearsuitable respiratory equipment. If ingested, seek medical advice immediately and show the container or the label. Avoidcontact with skin and eyes. Keep away from incompatibles such as oxidizing agents, acids.

Storage:Store in a segregated and approved area. Keep container in a cool, well-ventilated area. Keep container tightly closed andsealed until ready for use. Avoid all possible sources of ignition (spark or flame).

Section 8: Exposure Controls/Personal Protection

Engineering Controls:Provide exhaust ventilation or other engineering controls to keep the airborne concentrations of vapors below their respectivethreshold limit value. Ensure that eyewash stations and safety showers are proximal to the work-station location.

Personal Protection:Splash goggles. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Gloves.

Personal Protection in Case of a Large Spill:Splash goggles. Full suit. Vapor respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoidinhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling thisproduct.

Exposure Limits:TWA: 434 STEL: 651 (mg/m3) from ACGIH (TLV) [United States] TWA: 100 STEL: 150 (ppm) from ACGIH (TLV) [UnitedStates] STEL: 150 (ppm) from NIOSH STEL: 655 (mg/m3) from NIOSHConsult local authorities for acceptable exposure limits.

Section 9: Physical and Chemical Properties

Physical state and appearance: Liquid. (Mobile, nonpolar liquid.)

Odor: Aromatic. Sweetish.

Taste: Not available.

Molecular Weight: 106.17 g/mole

Color: Colorless.

pH (1% soln/water): Not applicable.

Boiling Point: 144.4°C (291.9°F)

Melting Point: -25°C (-13°F)

Critical Temperature: 359°C (678.2°F)

Specific Gravity: 0.88 (Water = 1)

Vapor Pressure: 0.9 kPa (@ 20°C)

Vapor Density: 3.7 (Air = 1)

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Volatility: Not available.

Odor Threshold: 0.05 ppm

Water/Oil Dist. Coeff.: The product is more soluble in oil; log(oil/water) = 3.1

Ionicity (in Water): Not available.

Dispersion Properties:Dispersed in diethyl ether. Is not dispersed in cold water, hot water. See solubility in diethyl ether, acetone.

Solubility:Soluble in diethyl ether, acetone. Insoluble in cold water, hot water.

Section 10: Stability and Reactivity Data

Stability: The product is stable.

Instability Temperature: Not available.

Conditions of Instability: Heat, ignition sources, flames, incompatible materials.

Incompatibility with various substances: Reactive with oxidizing agents, acids.

Corrosivity: Non-corrosive in presence of glass.

Special Remarks on Reactivity:Photochemically reactive. Incompatible with strong oxidizers(e.g. chlorine, bromine, fluorine), and strong acids (e.g. nitric acid,acetic acid).

Special Remarks on Corrosivity: Not available.

Polymerization: Will not occur.

Section 11: Toxicological Information

Routes of Entry: Absorbed through skin. Dermal contact. Eye contact. Inhalation.

Toxicity to Animals:Lowest Published Lethal Dose - Inhalation (LCL): 6125 ppm 12 hours [Rat]; 6125 ppm 12 hours [Human] Lowest PublishedLethal Dose - Oral: 5000 mg/kg [Rat]

Chronic Effects on Humans:CARCINOGENIC EFFECTS: A4 (Not classifiable for human or animal.) by ACGIH, 3 (Not classifiable for human.) by IARC.TERATOGENIC EFFECTS: Classified POSSIBLE for human. DEVELOPMENTAL TOXICITY: Classified Reproductive system/toxin/male [POSSIBLE]. May cause damage to the following organs: kidneys, liver, upper respiratory tract, skin, eyes, centralnervous system (CNS).

Other Toxic Effects on Humans: Hazardous in case of skin contact (irritant, permeator), of ingestion, of inhalation.

Special Remarks on Toxicity to Animals: Not available.

Special Remarks on Chronic Effects on Humans:May cause adverse reproductive effects (male) and birth defects based on animal data. 0347 Animal: embryotoxic, foetotoxic,passes through the placental barrier. 0900 Detected in maternal milk in human. Narcotic effect; may cause nervous systemdisturbances.

Special Remarks on other Toxic Effects on Humans:Acute Potential Health Efffects Skin: May cause skin irritation. May be absorbed through skin i harmful amounts. Eyes: Causessevere eye irritation. Inhalation: Causes respiratory tract and mucous membranes irritation. May affect sense organs, behavior(Central Nervous system) which may result in dizziness, general weakness, central nervous system depression, confusion,ataxia, disorientation, lethargy, drowsiness, headaches. May also affect respiration, cardiovascular system, liver, blood, anddigestive system (nausea, vomiting) Ingestion: Harmful if swallowed. Causes digestive tract irritation with nausea, vomiting

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and diarrhea. May also affect metabolism, liver, and urinary system, and central nervous system (excitement followed byheadache, dizziness, drowsiness and nausea). Chronic Potential Health Effects: Skin: Prolonged or repeated contact maycause defatting of skin and dermatitis. Eyes: Prolonged or repeated exposure may cause conjunctivitis or permanent eyedamage. Inhalation: Chronic inhalation may cause effects similar to those of acute inhalation.

Section 12: Ecological Information

Ecotoxicity: Not available.

BOD5 and COD: Not available.

Products of Biodegradation:Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise.

Toxicity of the Products of Biodegradation: The products of degradation are less toxic than the product itself.

Special Remarks on the Products of Biodegradation: Not available.

Section 13: Disposal Considerations

Waste Disposal:Waste must be disposed of in accordance with federal, state and local environmental control regulations.

Section 14: Transport Information

DOT Classification: CLASS 3: Flammable liquid.

Identification: : Xylene UNNA: 1307 PG: III

Special Provisions for Transport: Not available.

Section 15: Other Regulatory Information

Federal and State Regulations:Connecticut hazardous material survey.: o-Xylene Illinois chemical safety act: o-Xylene New York release reporting list: o-Xylene Pennsylvania RTK: o-Xylene Florida: o-Xylene Massachusetts RTK: o-Xylene Massachusetts spill list: o-Xylene NewJersey: o-Xylene New Jersey spill list: o-Xylene Louisiana spill reporting: o-Xylene California Director's List of HazardousSubstances: o-Xylene TSCA 8(b) inventory: o-Xylene TSCA 8(d) H and S data reporting: o-Xylene: Effective: 10/4/82; Sunset:10/4/92 SARA 313 toxic chemical notification and release reporting: o-Xylene CERCLA: Hazardous substances.: o-Xylene:1000 lbs. (453.6 kg)

Other Regulations:OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200). EINECS: This product is on theEuropean Inventory of Existing Commercial Chemical Substances.

Other Classifications:

WHMIS (Canada):CLASS B-2: Flammable liquid with a flash point lower than 37.8°C (100°F). CLASS D-2A: Material causing other toxic effects(VERY TOXIC).

DSCL (EEC):

HMIS (U.S.A.):

Health Hazard: 2

Fire Hazard: 3

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Reactivity: 0

Personal Protection: h

National Fire Protection Association (U.S.A.):

Health: 2

Flammability: 3

Reactivity: 0

Specific hazard:

Protective Equipment:Gloves. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respiratorwhen ventilation is inadequate. Splash goggles.

Section 16: Other Information

References:-Hawley, G.G.. The Condensed Chemical Dictionary, 11e ed., New York N.Y., Van Nostrand Reinold, 1987. -Material safetydata sheet emitted by: la Commission de la Santé et de la Sécurité du Travail du Québec. -The Sigma-Aldrich Libraryof Chemical Safety Data, Edition II. -Guide de la loi et du règlement sur le transport des marchandises dangeureuses aucanada. Centre de conformité internatinal Ltée. 1986.

Other Special Considerations: Not available.

Created: 10/11/2005 12:54 PM

Last Updated: 05/21/2013 12:00 PM

The information above is believed to be accurate and represents the best information currently available to us. However, wemake no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assumeno liability resulting from its use. Users should make their own investigations to determine the suitability of the information fortheir particular purposes. In no event shall ScienceLab.com be liable for any claims, losses, or damages of any third party or forlost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if ScienceLab.comhas been advised of the possibility of such damages.

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Material Safety Data SheetPalladium on Charcoal (5-10%) MSDS

Section 1: Chemical Product and Company Identification

Product Name: Palladium on Charcoal (5-10%)

Catalog Codes: SLP1597, SLP3406

CAS#: Mixture.

RTECS: Not applicable.

TSCA: TSCA 8(b) inventory: Palladium; Charcoal

CI#: Not applicable.

Synonym:

Chemical Name: Not applicable.

Chemical Formula: Not applicable.

Contact Information:

Sciencelab.com, Inc.14025 Smith Rd.Houston, Texas 77396

US Sales: 1-800-901-7247International Sales: 1-281-441-4400

Order Online: ScienceLab.com

CHEMTREC (24HR Emergency Telephone), call:1-800-424-9300

International CHEMTREC, call: 1-703-527-3887

For non-emergency assistance, call: 1-281-441-4400

Section 2: Composition and Information on Ingredients

Composition:

Name CAS # % by Weight

Palladium 7440-05-3 5-10

Charcoal 7440-44-0 90-95

Toxicological Data on Ingredients: Palladium LD50: Not available. LC50: Not available. Charcoal LD50: Not available.LC50: Not available.

Section 3: Hazards Identification

Potential Acute Health Effects: Slightly hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, ofinhalation.

Potential Chronic Health Effects:CARCINOGENIC EFFECTS: Not available. MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS: Not available.DEVELOPMENTAL TOXICITY: Not available. The substance is toxic to lungs, mucous membranes. Repeated or prolongedexposure to the substance can produce target organs damage.

Section 4: First Aid Measures

Eye Contact: No known effect on eye contact, rinse with water for a few minutes.

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Skin Contact:After contact with skin, wash immediately with plenty of water. Gently and thoroughly wash the contaminated skin with runningwater and non-abrasive soap. Be particularly careful to clean folds, crevices, creases and groin. Cover the irritated skin with anemollient. If irritation persists, seek medical attention. Wash contaminated clothing before reusing.

Serious Skin Contact: Not available.

Inhalation: Allow the victim to rest in a well ventilated area. Seek immediate medical attention.

Serious Inhalation:Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or waistband. Ifbreathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth resuscitation. Seek medicalattention.

Ingestion:Do not induce vomiting. Loosen tight clothing such as a collar, tie, belt or waistband. If the victim is not breathing, performmouth-to-mouth resuscitation. Seek immediate medical attention.

Serious Ingestion: Not available.

Section 5: Fire and Explosion Data

Flammability of the Product: Flammable.

Auto-Ignition Temperature: Not available.

Flash Points: Not available.

Flammable Limits: Not available.

Products of Combustion: Some metallic oxides.

Fire Hazards in Presence of Various Substances: Not available.

Explosion Hazards in Presence of Various Substances:Risks of explosion of the product in presence of mechanical impact: Not available. Risks of explosion of the product inpresence of static discharge: Not available.

Fire Fighting Media and Instructions:Flammable solid. SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use water spray or fog. Cool containing vesselswith water jet in order to prevent pressure build-up, autoignition or explosion.

Special Remarks on Fire Hazards: Material in powder form, capable of creating a dust explosion. (Charcoal)

Special Remarks on Explosion Hazards: Not available.

Section 6: Accidental Release Measures

Small Spill: Use appropriate tools to put the spilled solid in a convenient waste disposal container.

Large Spill:Spontaneously combustible solid. Stop leak if without risk. Absorb with an inert material and put the spilled material in anappropriate waste disposal. Obtain advice on use of water as spilled material may react with it. Do not touch spilled material.Prevent entry into sewers, basements or confined areas; dike if needed. Eliminate all ignition sources. Cover with wet earth,sand or other non-combustible material. Call for assistance on disposal. Be careful that the product is not present at aconcentration level above TLV. Check TLV on the MSDS and with local authorities.

Section 7: Handling and Storage

Precautions:Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not breathe dust.

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Storage:Flammable materials should be stored in a separate safety storage cabinet or room. Keep away from heat. Keep away fromsources of ignition. Keep container tightly closed. Keep in a cool, well-ventilated place. Ground all equipment containingmaterial. Keep container dry. Keep in a cool place.

Section 8: Exposure Controls/Personal Protection

Engineering Controls:Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommendedexposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminantsbelow the exposure limit.

Personal Protection: Safety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent.Gloves.

Personal Protection in Case of a Large Spill:Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoidinhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling thisproduct.

Exposure Limits:Charcoal TWA: 3.5 (mg/m3) from ACGIH (TLV)Consult local authorities for acceptable exposure limits.

Section 9: Physical and Chemical Properties

Physical state and appearance: Solid.

Odor: Not available.

Taste: Not available.

Molecular Weight: Not applicable.

Color: Dark.

pH (1% soln/water): Not applicable.

Boiling Point: Not available.

Melting Point: 3500°C (6332°F) based on data for: Charcoal. Weighted average: 3354.16°C (6069.5°F)

Critical Temperature: Not available.

Specific Gravity: Weighted average: 3.71 (Water = 1)

Vapor Pressure: Not applicable.

Vapor Density: Not available.

Volatility: Not available.

Odor Threshold: Not available.

Water/Oil Dist. Coeff.: Not available.

Ionicity (in Water): Not available.

Dispersion Properties: Not available.

Solubility: Insoluble in cold water.

Section 10: Stability and Reactivity Data

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Stability: The product is stable.

Instability Temperature: Not available.

Conditions of Instability: Not available.

Incompatibility with various substances: Not available.

Corrosivity: Non-corrosive in presence of glass.

Special Remarks on Reactivity: Not available.

Special Remarks on Corrosivity: Not available.

Polymerization: No.

Section 11: Toxicological Information

Routes of Entry: Not available.

Toxicity to Animals:LD50: Not available. LC50: Not available.

Chronic Effects on Humans: The substance is toxic to lungs, mucous membranes.

Other Toxic Effects on Humans: Slightly hazardous in case of skin contact (irritant), of ingestion, of inhalation.

Special Remarks on Toxicity to Animals: Not available.

Special Remarks on Chronic Effects on Humans: Not available.

Special Remarks on other Toxic Effects on Humans: Nuisance dust. (Charcoal)

Section 12: Ecological Information

Ecotoxicity: Not available.

BOD5 and COD: Not available.

Products of Biodegradation:Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise.

Toxicity of the Products of Biodegradation: The product itself and its products of degradation are not toxic.

Special Remarks on the Products of Biodegradation: Not available.

Section 13: Disposal Considerations

Waste Disposal:

Section 14: Transport Information

DOT Classification: CLASS 4.2: Spontaneously combustible substance.

Identification: : Carbon, activated (Charcoal) : UN1362 PG: III

Special Provisions for Transport: Not available.

Section 15: Other Regulatory Information

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Federal and State Regulations: TSCA 8(b) inventory: Palladium; Charcoal

Other Regulations: OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200).

Other Classifications:

WHMIS (Canada): CLASS D-2A: Material causing other toxic effects (VERY TOXIC).

DSCL (EEC):This product is not classified according to the EU regulations.

HMIS (U.S.A.):

Health Hazard: 1

Fire Hazard: 3

Reactivity: 0

Personal Protection: E

National Fire Protection Association (U.S.A.):

Health: 1

Flammability: 3

Reactivity: 0

Specific hazard:

Protective Equipment:Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respiratorwhen ventilation is inadequate. Safety glasses.

Section 16: Other Information

References: Not available.

Other Special Considerations: Not available.

Created: 10/10/2005 11:09 AM

Last Updated: 05/21/2013 12:00 PM

The information above is believed to be accurate and represents the best information currently available to us. However, wemake no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assumeno liability resulting from its use. Users should make their own investigations to determine the suitability of the information fortheir particular purposes. In no event shall ScienceLab.com be liable for any claims, losses, or damages of any third party or forlost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if ScienceLab.comhas been advised of the possibility of such damages.