General Presentation v.5. Introduction Biochemize S.L. Biochemize S.L. is a biotechnological company focused in the design and development of processes.
Dec 19, 2015
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General Presentation v.5
General Presentation v.5
IntroductionIntroduction
Biochemize S.L.Biochemize S.L. is a biotechnological company focused in the design and development of processes based on biocatalysis.
Our technological platform lies in the use of enzymes or microorganisms to perform chemical reactions able to substitute manufacturing processes based on classical organic chemistry.
General Presentation v.5
LocationLocation
We are located in Barcelona (Spain).
Our work takes place in the laboratories of our strategic partners:
CSIC-IQAC: Spanish Council for Scientific Research – Institute of Advanced Chemistry of Catalonia
IQS: Institut Químic de Sarrià
We are a CSIC-collaborating company
General Presentation v.5
LocationLocation
We have the corporative office also in Barcelona.
Barcelona Advanced Industry Park
And a commercial office in Bangalore (India), at the offices of our partner PolycloneBio.
General Presentation v.5
Our TechnologyOur Technology
Biochemize S.L.Biochemize S.L. develops bioprocesses using biocatalysts (enzymes or microorganisms) in single or multiple transformation steps.
Our technological platform P2BP2B (Platform to Biochemize) is capable to perform high throughput screening of biocatalysts, reaction conditions, suitable substrates and products obtained.
The screening can be done in a short period of time and renders information about different possible bioprocesses and conditions that could be further developed at a larger scale.
General Presentation v.5
P2B – P2B – Platform To BiochemizePlatform To Biochemize
P2BP2B is the key to determine quickly with low risk and at very small scale if a conceptual biotransformation is technologically viable.
Once the succeeding biocatalysts or bioprocesses have been identified, Biochemize S.L.Biochemize S.L. investigates at lab scale the experimental conditions which can lead to the highest yields.
Two approaches can be followed:
P2B BioprocessP2B Bioprocess
Development of bioprocesses suitable to substitute already established synthetic procedures up to an industrial scale
Perform biotransformations that can lead to a (new) chemical entity with improved features compared to the starting molecule
P2B DiscoveryP2B Discovery
General Presentation v.5
P2B – P2B – Platform To BiochemizePlatform To Biochemize
The information obtained from P2B-BioprocessP2B-Bioprocess allows estimations of productivity, costs and risks needed to confirm whether the process is feasible at industrial scale.
P2BP2B Lab ScaleLab Scale
Screening of biocatalysts &
conditions
Catalyst selection& conditions optimization
FeasibilityFeasibility
Estimation ofProductivity,
Costs & Risks
IndustrializationIndustrialization
General Presentation v.5
Products & ServicesProducts & Services
Biochemize S.L.Biochemize S.L. offers the following contract research services to customers:
Technical Assessments and Consulting
Development of biotechnology processes
Obtaining building blocks
Support in discovery of new chemical entities
General Presentation v.5
Products & ServicesProducts & Services
We offer theoretical evaluations and consulting to verify the feasibility of substituting chemical synthetic processes by biotechnology.(Experimental work is also possible)
Technical Assessments and Consulting Technical Assessments and Consulting
The assessments include estimations of yields, engineering needs, costs, risks, regulatory aspects, etc.
Biochemize S.L.Biochemize S.L. has a worldwide network of contacts: suppliers of biocatalysts, manufacturers, analytical services, researcher, advisors, etc.
We offer consulting and contact extension possibilities to customers through our own network.
General Presentation v.5
Products & ServicesProducts & Services
Substitution of processes based on synthetic organic chemistry by biotechnology.
Development of biotechnology processesDevelopment of biotechnology processes
AA BB CC DD
A Bioprocess can be more efficient, costs saving or less contaminant
A Bioprocess can be highly selective.
Sometimes allows reducing synthetic pathways (e.g. protection/deprotection steps)
The development ranges from theoretical design to industrial scale-up and implementation. This latter phase is carried out by the customer under the support and supervision of Biochemize S.L.Biochemize S.L.
General Presentation v.5
Products & ServicesProducts & Services
Building blocks can help to reduce synthesis steps of current processes or skipping reagents or intermediates hazardous, unstable, or complex to be obtained.
Obtaining of building blocksObtaining of building blocks
Building blocks obtained by biotechnology can be used as alternative source of reagents, starting materials and intermediates for chemical synthesis.
General Presentation v.5
Products & ServicesProducts & Services
Synthesis of potential new chemical entities through biotechnology approaches.
Biocatalysts can be used to obtain new lead, lead optimization, me-too and me-better compounds by modification of already available structures.
Strategy especially interesting for molecules of natural origin and/or complex structure.
Support in discovery of new chemical entitiesSupport in discovery of new chemical entities
Biotechnological transformations can be applied to obtain a new molecule without complex synthetic processes or avoiding the use of synthetic reagents that can deeply change the original structure.
Biochemize S.L.Biochemize S.L. can perform High Throughput Screening through the P2BP2B technology.
General Presentation v.5
OperationsOperations
Biochemize S.L.Biochemize S.L. offers the most outstanding and up to date technology options, while maintaining an industrial scope.
If necessary, many operations can be outsourced to other companies and research centres under our direction and supervision.
We have a powerful network of contacts in biocatalysis and bioprocessing. Several partnership agreements have been established.
AustriaBulgariaChinaDenmarkIrelandItalyKoreaNetherlandsSpainUnited KingdomUnited States
AdvisorsAnalytical ServicesBiocatalyst SuppliersBioprocessing ServicesBiotransformation ExpertsEnzyme ScreeningEnzyme ImmobilizationGenetic EngineeringManufacturersResearch & DevelopmentScaling-Up Services
General Presentation v.5
OperationsOperations
Biochemize S.L.Biochemize S.L. is able to perform many biocatalyzed transformations. Our most recent experience is based on the following reactions:
R CH2 OHR H
O
R OH
O
R O-R'
O
R N
O
R'
R''
R C N
AmideFormation, Hydrolysis,
Hydration & dehydration
NitrileFormation
& hydrolysis EsterFormation
& hydrolysis
Oxidation& Reduction
R
OH
X
Y
OAldol
reaction
TransamidationTransesterification
General Presentation v.5
Project ManagementProject Management
Biochemize S.L.Biochemize S.L. follows a project management approach which comprises several development phases:
PHASE II PHASE III PHASE IV PHASE VPHASE I
ExperimentalExploratoryResearch
TechnologyDevelopment
Scale-Up IndustrialImplement.
TheoreticalEvaluation
Biotransform.Screening
BiocatalystSelection &
Reproduction
CompoundCharacteriz.
Small ScaleProduction
BibliographyAssessment
P2BP2BDiscoveryDiscovery
P2BP2BBioprocessBioprocess
Each phase is not planned nor quoted until the previous phase is not completed and the results presented.
Control of Risks and Costs:
The customer decides the project continuation at each phase depending on results and conclusions obtained so far.
General Presentation v.5
Why contracting Biochemize?Why contracting Biochemize?
We offer the most outstanding and up to date technology options.
Industrial scope guaranteed: productivity, costs and risks are the key drivers of our evaluations.
Our technology platform (P2BP2B) is a powerful tool for fast, low risk and small scale proof of concept verifications.
We increase the success possibilities through the P2BP2B platform and our network of contacts.
Project management based on a development by phases approach.
The customer controls the risks and costs associated to the project development.
General Presentation v.5
ContactContact
Jaume Mir Founder
CEO and Business Development
E-mail: [email protected]
Cell phone: +34 693 72 39 23
Corporative Office
Marie Curie 8–14,08042 Barcelona, Spain
Barcelona Advanced Industry Park
E-mail: [email protected]
Telephone: +34 93 129 84 47
Commercial Office
437 40th Cross 5th Block Jayanagar
Bangalore 560041, India
Telephone: +91 80 266387667 67
General Presentation v.5
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