從先進的生物醫學成像看到未來的智能醫療...PDW T1-weighted (T1W) image, T2-weighted (T2W) image and proton density-weighted (PDW) are three categories anatomic image

FromAdvancedBiomedicalImagingtoFutureSmartHealthcare

從先進的生物醫學成像看到未來的智能醫療

Dr.KannieW.Y.ChanDepartmentofBiomedicalEngineering

CityUniversityofHongKongOct2019 1

Imaging

Ø Howmanyphotosdoyoutakeperday?

Ø Snapshot,videoorselfie

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Face Recognition

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1. CAPTURINGScanningexistingimagesorusingcameras

2. EXTRACTINGUniquefacialdataisextractedfromtheimage

3. COMPARINGThedataiscomparedwiththedatabase

4. MATCHINGThesoftwarethendecideswhethertheimagematchesanypictureinthedatabaseornot

Applications Facerecognition

o Accesscontrolo Paymento Security(e.g.airport,creditcard–frauddetection)o Criminalidentificationo SurveillanceoMarketingo Vendingmachine(UK)

o Healthcare

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R.Weissleder,M.J.Pittet,NatRev2008,452,580PET,positronemissiontomographLN-MRI,lymphotropicnanoparticle-enhancedMRIMSCT,multisliceCT

Development of Medical Imaging Modalities

Biomedical Imaging - fMRI

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Biomedical Imaging Chest X-Ray: Lung Cancer

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https://aimi.stanford.edu/medical-imagenet

Artificial Intelligence to improve imaging - Deep Learning

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https://aimi.stanford.edu/medical-imagenet

Ø  Provide ample and indepth information

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Biomedical imaging + Artificial Intelligence

MRI Human Brain

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3D Angiography

https://www.youtube.com/watch?v=aoBLGytBesg

Diffusion MRI

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https://www.youtube.com/watch?v=Bjd8nPKKIU4

1.CAPTURINGUsingmedicalimagingmodalities

2.EXTRACTINGImagefeaturesareextracted

3.COMPARINGThedataiscomparedwiththedatabase

4.MATCHINGSimilaritiesanddifferencescanassistdiagnosis

Biomedical imaging + Artificial Intelligence

Healthcare applications Ø Cloudhealthcare

14https://www.carestream.com/en/us/medical/products/vue-healthit/cloud-services-for-medical-enterprises

Cloud Database

Healthcare applications - Robot

Focus areas at BME Courses:o  HealthMaintenanceandWellness

Technologyo  BiomedicalInstrumentationo  MedicalImagingandSignal

Processingo  RadiologicalPhysicsandDosimetryo  RoboticsandMachineVisiono  BiosafetyandSecurityo  TissueEngineeringo  BiosensorsandBiodeviceso  ElectricalandElectronicPrinciples

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Robotics and AI for

Biomedical Applications

Cell and Tissue

Engineering

Biomedical Sensors and Informatics

Biomedical Imaging and

Instrumentation

Learning Activities Ø Biomedicalimaginglabclass

o FirstMRIlabforundergraduates

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Preclinical MRI for Biomedical Imaging Laboratory（預臨床生物醫學磁共振成像實驗室）

Bruker BioSpec 3T MRI

At a translational field of 3 Tesla, this small animal scanner extends the range of multi-parametric, preclinical magnetic resonance imaging (MRI) in a compact design with the advanced cryogen-free magnet technology. It comprises of the latest MRI technology, software packages and multimodal options, such as positron emission tomography (PET). This 3T scanner can achieve a variety of biomedical imaging applications, such as anatomic relaxation imaging, angiographic imaging and imaging neurological functions using diffusion tension imaging and functional MRI. Moreover, it can perform molecular imaging using MRS and Chemical Exchange Saturation Transfer (CEST) MRI.

Mouse Brain Relaxation ImagingAxial Coronal Sagital

T1W

T2W

PDW

T1-weighted (T1W) image, T2-weighted (T2W) image and proton density-weighted (PDW) are three categories anatomic image which can provide different structural contrast. A short TR and short TE sequence is usually called T1-weighted; A long TR and long TE sequence is usually called T2-weighted; A long TR and short TE sequence is usually called PD-weighted. As we can see from above, we can acquire high-quality anatomic relaxation images on this 3T BioSpec MRI scanner.

Axial Coronal

Sagital

We can acquire high-resolution T2Wimages of a mouse body, which show the anatomy of the gastrointestical tract, liver, kidneys and spine at this 3T clini-cal field strength animal scanner.

Body Imaging (T2W)

Designed by Jianpan Huang

Preclinical MRI for Biomedical Imaging Laboratory（預臨床生物醫學磁共振成像實驗室）

Bruker BioSpec 3T MRI

At a translational field of 3 Tesla, this small animal scanner extends the range of multi-parametric, preclinical magnetic resonance imaging (MRI) in a compact design with the advanced cryogen-free magnet technology. It comprises of the latest MRI technology, software packages and multimodal options, such as positron emission tomography (PET). This 3T scanner can achieve a variety of biomedical imaging applications, such as anatomic relaxation imaging, angiographic imaging and imaging neurological functions using diffusion tension imaging and functional MRI. Moreover, it can perform molecular imaging using MRS and Chemical Exchange Saturation Transfer (CEST) MRI.

Mouse Brain Relaxation ImagingAxial Coronal Sagital

T1W

T2W

PDW

T1-weighted (T1W) image, T2-weighted (T2W) image and proton density-weighted (PDW) are three categories anatomic image which can provide different structural contrast. A short TR and short TE sequence is usually called T1-weighted; A long TR and long TE sequence is usually called T2-weighted; A long TR and short TE sequence is usually called PD-weighted. As we can see from above, we can acquire high-quality anatomic relaxation images on this 3T BioSpec MRI scanner.

Axial Coronal

Sagital

We can acquire high-resolution T2Wimages of a mouse body, which show the anatomy of the gastrointestical tract, liver, kidneys and spine at this 3T clini-cal field strength animal scanner.

Body Imaging (T2W)

Designed by Jianpan Huang

Bioluminescence Imaging

Ultrasonicsensor

Touchsensor

Soundsensor

Lightsensor

Learning Activities Ø  Robots

Dr. King W.C. Lai Email: [email protected]

Oversea Exchange/ Internship /Study Tour

Student Competitions / Awards

HKEIA Innovation & Technology Project Competition 2016

Cybathlon Championship for Athletes with Disabilities 2016

International Genetically Engineered Machine (iGEM) 2015

Hong Kong Medical and Healthcare Device Industries Association (HKMHDIA)

2017

International Invention Innovation Competition in Canada (iCAN) 2018

Robocon 2016

Career Ø WorldHealthOrganization(WHO)

Ø MedicalphysicistsØ BMEdepartmentsathospitalsØ BESS(BiomedicalEngineeringServiceSection)atHospitalAuthorityØ Biotechnology/Healthcareindustry(e.g.Medicaldevice)

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Imaging for medical purposes involves a team which includes theservice of radiologists, radiographers (X-ray technologists),sonographers (ultrasound technologists), medical physicists, nurses,biomedical engineers, and other support staff working together tooptimize thewellbeing of patients, one at a time. Appropriate use ofmedicalimagingrequiresamultidisciplinaryapproach.

Five technologies that will revolutionize healthcare by 2020

Ø ArtificialIntelligenceo machineorsoftwarewiththeabilitytodepictormimichumanbrainfunctions

Ø 3Dprintingo tissueengineering

Ø LiquidBiopsyo cancerdetection

Ø  Immunotherapyo cancertherapy

Ø CRISPRo geneediting

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https://www.forbes.com/sites/reenitadas/2016/03/30/top-5-technologies-disrupting-healthcare-by-2020/#607477f26826

Contact us

Department of Biomedical Engineering City University of Hong Kong Rm Y6700, 6/F, Yellow Zone, Yeung Kin Man Academic Building

Phone: 3442-8420 Email: [email protected]

Dr. Kannie W.Y. Chan Email: [email protected]

Dr. King W.C. Lai Email: [email protected]

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