Descriptive Epidemiology of Childhood Leukaemia...Leukaemia is a malignancy of the bone marrow. It affects the cells that produce white blood cells. The main types of childhood leukaemia

Descriptive Epidemiology of

Childhood Leukaemia

C.MagnaniCPO Piemonte and University of Eastern

Piedmont

Leukaemia is a

malignancy of the bone

marrow.

It affects the cells that

produce white blood

cells.

The main types of

childhood leukaemia

are acute lymphoblastic

(ALL) and acute non

lymphoblastic (ANLL).

ALL are classified according to immunophenotype:

T-cell 9.5%

B-cell 4.1%

preB / common 86.2%.

ANLL are classified according to the FAB classification.

M1-M2 acute myeloid 32.1%

M3 promyelocitic 35.7%

M4 myelomonocitic 17.9%

M5 monocitic 7.1%

Other 7.2%

Childhood Cancer Registry of Piedmont, 1998-2002:

ICCC

I Leukemia (a) Lymphoid Leukemia - Acute lymphocytic leukemia (ALL)

- Lymphoid excluding ALL

(b) Acute non-lymphocytic leukemia

(c) Chronic myeloid leukemia

(d) Other specified leukemia

(e) Unspecified leukemia

Current classification in epidemiology is the

ICCC-2

ICCC-3, based on ICD-O-3

I Leukemias, myeloproliferative diseases, and myelodysplastic dise

(a) Lymphoid leukemias

(a.1) Precursor cell leukemias

(a.2) Mature B-cell leukemias

(a.3) Mature T-cell and NK cell leukemias

(a.4) Lymphoid leukemia, NOS

(b) Acute myeloid leukemias

(c) Chronic myeloproliferative diseases

(d) Myelodysplastic syndrome and other myeloproliferative disease

(e) Unspecified and other specified leukemias

II Lymphomas and reticuloendothelial neoplasms

(a) Hodgkin lymphomas

(b) Non-Hodgkin lymphomas (except Burkitt lymphoma)

(b.1) Precursor cell lymphomas

(b.2) Mature B-cell lymphomas (except Burkitt lymphoma)

(b.3) Mature T-cell and NK-cell lymphomas

(b.4) Non-Hodgkin lymphomas, NOS

(c) Burkitt lymphoma

(d) Miscellaneous lymphoreticular neoplasms

(e) Unspecified lymphomas

Accis, EJC 2006

Leukemia, age 0-14

Accis, EJC 2006

Leukemia incidence in Europe

Accis 1988-1997

0

5

10

15

20

25

30

35

40

45

Europe British I. East North South West

A.S

.In

cid

en

ce

(x

mil

lio

n)

ALL

ANLL

Time trends in incidence

Incidence by age and gender

Figure 2. Acute Lymphoblastic Leukaemia. Incidence rates by year of age and period

0,0

20,0

40,0

60,0

80,0

100,0

120,0

140,0

160,0

180,0

0 1 2 3 4 5 6 7 8 9 10 11 12 13 14

Age at diagnosis (years)

Incid

en

ce R

ate

(p

er

millio

n)

75-79

80-84

85-89

90-94

95-98

CCR Piedmont

ALL incidence in Europe, 1970-1999. ACCIS database

E. Steliarova_Foucher et al. Lancet 2004

Eur J Cancer, 2006; 42:78-83.

Leukaemia 0-14

0

1

2

3

4

5

1970 1975 1980 1985 1990 1995 2000

year of death

std

. ra

tes (

eu

r.p

op

.) x

100,0

00

Males

Females

Mortality for leukaemia age 0-14, Italy

Survival for ALL age 0-14, Italy

Survival for ANLL age 0-14, Italy

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