Department of Life Sciences Biological Sciences –Botany, Zoology, Marine Biology, Microbiology, Biochemistry, Molecular and Cell Biology, etc. Agricultural.

Department of Life Sciences Biological Sciences

– Botany, Zoology, Marine Biology, Microbiology, Biochemistry, Molecular and Cell Biology, etc.

Agricultural Sciences– Agronomy, Horticulture, Forestry, Fishery, Animal Husbandry, Veterinary Science, Agricultural Chemistry, Food Science, etc.

Medical Sciences– Basic Medical Sciences: Anatomy, Physiology, Pharmacology,

Biochemistry, Microbiology and Immunology, Molecular Medicine, Epidemiology, Public Health and Occupational Medicine, Legal Medicine and Forensic Science, etc.

– Clinical Sciences: Internal Medicine, Surgery, Radiology, Nuclear Medicine, Gynecology and Obstetrics, Pediatrics, Dentistry, etc.

National Science and Technology Programs– Agricultural Biotechnology, – Genomics Medicine, – Pharmaceutical Biotechnology.

1996-2005 Annual Budget, Dept. of Life Sciences

49,58857,028

66,43777,431 77,960

87,918 90,533

108,101108,477115,264

0

50,000

100,000

150,000

1997 1998 1999 2000 2001 2002 2003 2004 2005 2006

(Thousand USD)

2,820

4,7984,7194,5904,348

3,1622,9442,786

4,157 4,900

3,684

2,246 2,8532,9362,790

2,2012,0692,016

2,601

3,1232,842

1,467

65%

72%70%

68% 64%64%

70% 71%

58%65%

60%

0

1000

2000

3000

4000

5000

6000

`96 `97 `98 `99 `00(1)̀ 00(2) `01 `02 `03 `04 `05Year

(Grant Number)

0%

10%

20%

30%

40%

50%

60%

70%

80%

90%

100%

Application Numbers

Funding Numbers

Funding Rate ( % )

Life Sciences Grant Applications and Funding

Department of Life SciencesFunding Policy Individual Grant Program Project Frontier Science Program Team of Excellence Program Inter-ministerial Health Food R & D Program Inter-disciplinary Integration Program International(Bilateral) Collaboration ProgramIndustrial-University Collaboration R & D ProgramBiotechnology Successful Investment Program National Science and Technology Research Program Genomic Medicine S & T Research Program Biotechnology Pharmaceuticals S & T Research Program Agriculture Biotechnology S & T Research Program

Bioengineering Program Project

To focus on research fields with integrated efforts of inter-departments, inter-institutes, and inter-universities.

To promote international collaboration

Major research areas:1. Functional tissue/molecular imaging2. Mobile monitoring and distributing wireless

integrated sensors system3. Biomedical optics and biophotonic monitoring

systems4. New biomechanics of tissues, cells, and genes5. Tissue and cell engineering and new

biomaterials

6

Bioinformatics Multidisciplinary Research Programs

Genome annotation and development of its tools

Microarray and proteomic data analysis and value-added data bank

Macromolecular sequencing and structural data analysis

Phylogenetic data analysis

Industry-University Cooperative Research Program

To promote advanced and applied technology research by the academic community, and also to encourage enterprises to actively participate in applied academic research, and thereby to enhance the R&D capabilities and skilled manpower of private sectors.

8

The Budget for the National Science and Technology Program

million USD

NSTPAB ： National Science and Technology Program for Agricultural BiotechnologyNSTPBP ： National Science and Technology Program for Biotechnology and Pharmaceuticals

NRPGM ： Nation Research Program for Genomic MedicineSARS ： SARS Research Project

Year 2000 2001 2002 2003 2004 2005 2006NSTPAB 5.31 3.85 4.57 9.47 10.97 6.67 6.81 NSTPBP 4.29 3.10 6.58 4.48 6.25 8.14 7.50 NRPGM - - 56.49 53.40 36.00 36.80 31.25 SARS 2.35

Agricultural Biotechnology National Program

Fifteen Research Teams

Development and integration of floral (Chrysanthemum and orchids) production and marketing systems.

Integration and industrial application of conventional and genetic-engineered post-harvest technology for vegetables and fruits.

Integration of key techniques for organic farming (e.g. stress tolerant varieties, bioprotectants and biofertilizers).

Promotion and establishment of production systems for high quality Chinese herbs and health foods.

Development of fry production systems with quality assurance (shrimp and grouper) and related transportation and marketing technology.

Biotechnology applications in the production of Taiwan tilapia for international market.

Application of biotechnology in the improvement of cage-culture and processing technology for Cobia.

Agricultural Biotechnology National Program

Fifteen Research Teams Agricultural waste treatments in generating value-added by-

products. Inventing and improving production systems for high quality

swine and chicken. Developing biological agents (vaccines and adjuvants) for

plant- and animal-related applications. Application of transgenic technology for ornamental plants

and fishes, and for medical and feed industries. Development of molecular techniques for diagnostic systems

and marker-assisted breeding. Development of bioreactor technologies for producing

industrial and medical materials. Establishment of GMO assessment and accrediting systems. Research and development of novel functional genomics

based technologies for biotechnological industries.

D.C.N. Chang

SWEET RICEtransgenic rice seeds expressing

an amylopullulanase (APU) gene

S.M. Yu and J.F. Shaw

National Program in Biotechnology and Pharmaceuticals(1999-2006)

• Natural Products • Synthetic Chemicals • Protein Drugs• Protein Chips• Drug Screening and Evalulation• Clinical Trials • Industrial Applications and Technology

Transfer

R&D on YC-1 and its Derivatives Project

Academics ： China Medical University （ Sheng-Chu Kuo ）， National Taiwan University College of Medicine （ Che-Ming Teng ）

Enterprise ： Health BioX Biotech. Co. （ Fang-Yu Lee ）

Niche ： PCT patents with multi-indications, over 170 international SCI papers acknowledgements

Challenge ： Compete with other pharmaceutical companies such as Aventis and Bayer etc.

Targets： 1. YC-1 clinical trial (US and Taiwan)

2. R&D on follow-up YC-1 derivatives

3. Establishment of a R&D Center

Project for Development of Microfluidic Biochip Systems

Academy ： National Cheng Kung University （ Gwo-Bin Lee, Shu-Hui Chen, Jiunn-Jong Wu, Ching-Hsing Luo, Mei-Ling Tsai, Jyh-Ming Ting, Chih-Ching Chang ）Enterprise ： President Biosystem Inc.Niche： 7 patents (10 in patent application process) Challenge ： Competition with overseas companiesTargets： 1. Develop a series of advanced biochip systems 2. Development of biochips for early detection of virus/bacteria –

related diseases.The developed microfluidic biochip systems have successfully demonstrated their capability for fast diagnosis of virus/bacteria-related diseases. This project will collaborate several local companies to start up a competitive bio-MEMS company.

Sensor Heaters可攜式細胞前處理及 PCR模組

PCR 溫度控制元件照片Portable apparatus for cell pretreatment and PCR chips.

National Science and Technology Program

on Genomic Medicine (2002 - 2009)

CANCER

LIVERLUNG

ELSI

INFECTIOUS DISEASES

HIGHLY HERITABLE DISEASES

INNOVATIVE RESEARCH

IndustrialCooperation

InteranationalCooperation

Core facilitiesThe National Program attempts to coordinate national resources and to fund projects that are in line with Taiwan’s strategic development. Comprehensive cores have been established to support various scientific programs.

Six major core facilities:

Mutant Mouse Facility and Disease Models Clinical Tissues Bank High Throughput Genomics Facilities Proteomics and Structural Biology Facilities Bioinformatics Innovation and Key Technology Development

Result in Lung Cancer1. Many tumor suppressor genes (TSGs) had 5’CpG hypermethylation

in their promoter and/or exon1 regions in lung cancer. 2. These TSGs are: hMLH1 and hMSH2, p16INK4a), p14ARF, FHIT,

BLU, RASSF1A, RARβ, HIF, SLIT2, BRCA1/2.3. Overexpression of DNA methyltransfer enzymes (DNMTs)

contributes to NSCLC tumorigenesis and associate with 5’CpG hypermethylation in their target TSGs.

The mRNA and protein of DNMTs were highly expressed in tumor tissue.

ENU mutagenesis established mice with mitochondrial branched-chain aminotransferase deficiency resembling human maple syrup urine disease. (J. Clin. Invest. 2004)

ENU mutagenesis mouse models of human metabolic disease