C.v. dr. secades (dec2015)

CURRICULUM VITAE

PERSONAL DATA

- Name: Julio José SECADES RUIZ - Date of birth: 26th February, 1960 - N.I.C.: 36.937.233-s - Address: Avda. Mare de Deu de Montserrat 196, bajos. 08041 – Barcelona (Spain). - Phone: +3493 435 94 62 - Mobile phone: +34607 237 889 - E-mail: [email protected]

[email protected] - Collegiate No.: 19,891 (C.O.M.B.).

ACADEMIC RECORD

• MEDICINE: − Licentiate in Medicine and General Surgery by the Central University of Barcelona

in 1983. − Doctor in Medicine and Surgery by the Autonomous University of Barcelona in

1998. − Diploma in Psychogeriatry and Neurogerontology. − Diploma in Computer-assisted Cognitive Rehabilitation (GRADIOR program). • OTHER STUDIES − Arthur Erickson’s Marketing Diploma (1978). − Scheidegger’s Marketing Diploma. − Scheidegger’s BASIC Programming Diploma. − Scheidegger’s Computer Science Diploma. • MEMBER OF SCIENTIFIC SOCIETIES: − American Association for the Advancement of Science - AAAS (until 2008). − The New York Academy of Science (until 2000). − American Heart Association (Stroke Council). • LANGUAGES:

- Spanish (Mother language) - Catalan (High level) - English (High level) - French (Medium level) - Thai (Beginner level)

-

PROFESSIONAL TRAINING − 1979-1983: Boarder by competition of the Neurosurgery Service of the “Hospital

Clínico y Provincial” in Barcelona. − 1983-1984: Assistant Physician of the Neurosurgery Service of the “Hospital

Clínico y Provincial” in Barcelona. − 1985-1989: Collaborating Physician of the Neurosurgery Service of the “Hospital

Clínico y Provincial” in Barcelona. − 1988-1989: During these years I stayed for 2 periods of 6 months each at the

Neurosurgery Service of the “Hospital Xeral de Galicia”, under the auspices of Prof. F. Reyes Oliveros, as a Voluntary Assistant Physician, collaborating in the experimental research works (cerebral vascular pathology and implantation of neural tissue) at the Microsurgery Unit of the University Institute “Pedro Barrié de la Maza”.

− Since 1989: Medical Adviser of the Neuropharmacology Division of the Ferrer

Group, S.A. During this time my tasks are the normal ones, involving this position, such training sales forces, review of literature regarding our products and those related, pharmacovigilance, collaboration with Marketing in the promotion of the drugs, participation in meetings and congresses, assistance to our licensees worldwide (mainly for medical aspects regarding our products), promotion of our drugs in scientific events, planning clinical trials (phase III and IV) and some experimental research, advise about new licensing opportunities, writing scientific materials (books, reviews, papers,…), and institutional relationships. I coordinated and I participated as a member of the Steering Committee of the ICTUS trial.

− 1995-1998: Doctor’s degree at the Neurosurgery Service of the “Hospitals de la

Vall d’Hebrón” in Barcelona, under the auspices of Prof. E. Rubio, who directed my doctor’s degree on endothelin-1 and cerebral vasospasm after subarachnoid hemorrhage.

ATTENDANCE TO COURSES AND SEMINARIES

− Ist Course of Basic E.C.G., organized by the Cardiology Service and Coronary

Unit of “C.M. Salus” in Barcelona (May 1981) − Course on Vascular Retinopathies, organized by the Ophthalmology

Department of the “Hospital Clinic” in Barcelona (May 1981) − Basic Course of Immunology, organized by the “C.M.U. Montseny” in

Barcelona (February 1982) − VIth Course of Neurological Therapy, organized by the Neurology Service of

the “Hospital del Sagrado Corazón” in Barcelona (April/May 1983) − Vth Course of Medical Emergencies, organized by the Emergencies Service of

the “Hospital Clinic” in Barcelona (October 1984) − Ist Course of Etiologic Diagnosis in Neurology, organized by the Neurology

Service of the “Hospital General Nuestra Señora del Mar” in Barcelona (November 1984)

− Course on Bases of the Pharmacologic Treatment in Intensive Care

Units: Central Nervous System, organized by the Intensive Medicine Service of the “Hospital Son Dureta” in Palma de Mallorca (October 1989)

− Course of Stereotaxic Cerebral Surgery, organized the “Policlínica

Guipúzcoa” in San Sebastián (May 1990) − Course on Cranioencephalic Traumatisms, organized by the Neurosurgery

Service of the “Hospital Virgen de Arrixaca”, Murcia (May 1991) − XIVth Course of Biomechanics of the Locomotive Apparatus, organized by

the “Hospital de San Rafael”, Barcelona (March 1992) − VIth Course of Spinal Column: Lumbalgias, organized by the C.T. Institute

and R. ASEPEYO, Barcelona (April 1992) − Course of Doctor’s degree and Continued Training on Cerebral Tumors,

organized by the Neurosurgery Service of the “Hospital de la Santa Creu i Sant Pau”, Barcelona (June 1992)

− Ist International Course on Neurogerontology and Psychogeriatrics,

Euroespes Foundation, La Coruña (May 1993)

− Course on Diagnostic and Therapeutic Advances in Cerebral Vascular

Pathology, organized by the Neurosurgery Service of the “Hospital de la Santa Creu i Sant Pau”, Barcelona (June 1993)

− IIIrd Course of Intracranial Pressure and Cerebral Hemodynamics

Monitoring. Updates in the neurocritical patient monitoring and treatment. Neurosurgery Service. Neurotraumatology Unit. “Hospitales de la Vall d’Hebrón”, Barcelona (May 1996)

− Ist International Course of Vascular Neurosurgery, organized by the

Neurosurgery Service of the “Hospitales de la Vall d’Hebrón”, Barcelona (October 1996)

− Course of Neuropsychological Rehabilitation of cognitive impairment.

Application of new technologies, organized by the INTRAS Foundation, Barcelona (January 2000)

− IXth Course in Spanish of the American Academy of Neurology, Miami

(November 2000) − Continuous Training on Biostatistics following the Educational

Programme of the Department of Statistics and Operational Research of the Polithecnical University of Barcelona

− International Course of Internal Medicine of North America, México DF

(July 2010)

ATTENDANCE TO CONGRESSES

Jornadas de Enfermedades Infecciosas de la Asociación Catalana de Medicina Interna (Conference on Infectious Diseases of the Catalan Association of Internal Medicine) (April 1982)

Symposium on Head Injuries, organizado por el Servicio de Neurocirugía del Hospital General "Valle de Hebrón" de Barcelona (October 1984)

8th European Congress of European Association of Neurosurgical Societies, Barcelona (September 1987)

I European Congress of Videosurgery and II National Congress of Emergency Surgery, Barcelona (November 1987)

Periodic Meetings of the Ctalan Society of Neurosurgery (until 2000)

International Symposium "Hypertension 89", Barcelona (June 1989)

XLI Meeting of the Luso-Spanish Society of Neurosurgery, San Sebastián (May 1990) VIII Nacional Congress of Neurology (Joint Meeting with the British Neurological Society), Valencia (May/June 1990)

International Symposium: Pharmacology of Traumatic Brain Injury, Toledo (June 1990) I Internacional Symposium on Treatment of CNS Aneurysms and Angiomas, La Coruña (September 1990) International Conference of Recent Advances in Neurotraumatology (ICRAN-90), Oporto (October 1990)

I Internacional Symposium Internacional on Vascular Pathology of Brain and Spinal Cord: Advances in Diagnosis and Therapeutics, Zaragoza (March 1991)

XLII Meeting of the Luso-Spanish Society of Neurosurgery, León (May 1991) International Symposium on Vascular Dementia, Alicante (June, 1991) II European Congress of Gerontology, Madrid (September 1991)

I Congress of the Spanish Society of Psychiatric Epidemiology, Palma de Mallorca (September 1991)

XVI Meeting of the Spanish Society of Biological Psychiatry, Vitoria (October 1991)

I Meeting on Updates on Headache, Palma de Mallorca (November 1991)

International Symposium on Calcium Antagonists and Neurological Disorders, Madrid (March 1992)

Extraordinary Meeting of the Spanish Society of Neurology, Platja d'Aro (June 1992) III National Congress of the Spanish Society of Biological Psychiatry, Pamplona (June 1992)

I Meeting EUROESPES on Clinical Use of Calcium Antagonists, Pontevedra (May 1992)

I Meeting EUROESPES on Restorative Therapies of the Neuronal Membrane, Valladolid (June 1992)

Conference of the Spanish Society of Geriatrics and Gerontology on Senile Brain and Related Pathologies, Barcelona (October 1992)

XLIV Annual Meeting of the Spanish Society of Neurology, Barcelona (December 1992)

Symposium the Decade of the Dementia, Palma de Mallorca (January 1993) International Symposium on Brain Aging, Fundación Ramón Areces, Madrid (December 1993) XLV Annual Meeting of the Spanish Society of Neurology, Barcelona (December 1993)

V National Congress of the Spanish Society of Biological Psychiatry, Palma de Mallorca (June 1994)

IVth Meeting of the European Neurological Society, Barcelona (June 1994). XLVI Annual Meeting of the Spanish Society of Neurology, Barcelona (Diciembre, 1994). IVth European Stroke Conference, Bordeaux (June 1995). 5th Meeting of the European Neurological Society, Munich (June 1995). XLVII Annual Meeting of the Spanish Society of Neurology, Barcelona (December 1995). 48th Annual Meeting of the American Academy of Neurology, San Francisco (March 1996).

I Meeting of the Spanish Society of Neurosurgery (Joint Meeting with the Portuguese Society of Neurosurgery), Salamanca (May 1996)

XLVIII Annual Meeting of the Spanish Society of Neurology, Barcelona (December 1996)

IL Annual Meeting of the Spanish Society of Neurology, Barcelona (December 1997)

IV Congress of the Spanish Society of Neurosurgery, Burgos (May 1999)

XI National Congress of the Spanish Society of Neurology, Santiago de Compostela (May 1999) II National Conference on Alzheimer’s Disease, Bilbao (November 1999). LI Annual Meeting of the Spanish Society of Neurology, Barcelona (December 1999). Every year from this one.

25th International Stroke Conference, New Orleans (February 2000), from this one I assisted to every conference, that is every year in the different places where the Conference is done

10th European Stroke Conference, Lisbon (May 2001), from this one I assisted to every conference, that is every year in the different places where the Conference is done

126th Annual Meeting of the American Neurological Association, Chicago, IL (October 2001).

IXth International Symposium on Thrombolysis and Acute Stroke Therapy, Whistler, Canada, (June 2004)

5th World Stroke Conference, Vancouver, Canada (June 2004) 5th STAIR Meeting, Washington DF, USA (March 2006) Congress of the Venezuelan Society of Critical Medicine, Isla Margarita, Venezuela (June 2006) Joint World Congress on Stroke, Cape Town, South Africa (October 2006) UPC Course of Critical Analysis of Clinical Trials (as guest professor), Barcelona (February 2007) ASNA 2007, Cha-Am, Thailand (March 2007) Annual Meeting of The Bulgarian Neurosurgical Society, Devin, Bulgaria (October 2007) 2nd Congress of the Sociedade Portuguesa do Acidente Vascular Cerebral, Cascais, Portugal (January 2008) APCAS 2008, Manila, the Philippines (March 2008) Xth International Symposium on Thrombolysis and Acute Stroke Therapy, Budapest, Hungary (October 2008) 6th World Stroke Congress, Viena, Austria (October 2008) Academy of Filipino Neurosurgeons, Manila (December 2008) International Course of Internal Medicine of North America, México DF (July 2010)

4th Western China International Neuroscience Forum, Tengchong, China (August 2010) APSC, Sri Lanka (October 2011) 3rd Congress of the Vietnamese Stroke Society, Hue, Vietnam (April 2012) XXVII Congreso Nacional de Neurología. Asociación Guatemalteca de Neurología. Antigua, Guatemala (November 2012) 7th World Congress on Controversies in Neurology. Istanbul, Turkey (April 2013) International scientific-practical conference "Actual problems of neurology", dedicated to the 80th anniversary of the Nervous Diseases Department, carried out within "125 years of S.D. Asfendiyarov. Almaty, Kazakhstan (6-7 June 2014) National Conference of Neurology, Varna, Bulgaria (12-15 June 2014) 16th CNC - Cairo International Neurology Conference. Cairo, Egypt (18-20 March 2015) III International Congress of Neurological Surgeons of Kyrgyzstan. Cholpon-Ata, Kyrgyzstan (21-22 August 2015)

COMMUNICATIONS

-"Antagonistas del calcio: Mecanismos de acción y aplicaciones terapéuticas [Calcium Antagonists: Mechanisms of Action and Therapeutic Applications]". Conference at Centro de Asistencia Primaria de Martorell, Spain (December 1985)

-"Heridas craneocerebrales por arma de fuego [Craniocerebral gunshot wounds]". Conference at the meeting of the Catalan Society of Neurosurgery, Barcelona, Spain (February 1986)

-"Osteoma osteoide cervical". XXVIII Meeting of the Luso-Spanish Society of Neurosurgery, Coimbra, Portugal (May 1986)

-"Hemorragias cerebrales. Discusión de un protocolo de tratamiento [Brain hemorrhages: Discussion about a treatment protocol]". Hospital Clínico y Provincial de Barcelona, Spain (May 1986)

-"Hemorragia espontánea del cerebelo en el adulto. Análisis de 15 casos [Spontaneous Cerebellar Hemorrhage in Adults: Analysis of 15 cases]". Winter Meeting of the Catalan Society of Neurosurgery, Baqueira-Beret, Spain (February 1987)

-"Hemorragia subaracnoidea: Diagnóstico y tratamiento [Subarachnoid hemorrhage: Diagnostic and treatment]". Hospital Clínico y Provincial de Barcelona, Spain (March 1987)

-"Hemorragia espontánea del cerebelo en el adulto [Spontaneous Cerebellar Hemorrhage in Adults]". Hospital Clínico y Provincial de Barcelona, Spain (April 1987)

-"Cavernous hemangioma of the cavernous sinus". 8th European Congress of Neurosurgery, Barcelona, Spain (September 1987)

-"Heridas craneocerebrales por arma de fuego. Análisis de 36 casos [Craniocerebral gunshot wounds: Analysis of 36 cases]". I European Congress of Videosurgery and II National Congress of Emergency Surgery, Barcelona, Spain (November 1987)

-"Hematomas epidurales diferidos [Delayed Epidural Hematomas]". I European Congress of Videosurgery and II National Congress of Emergency Surgery, Barcelona, Spain (November 1987)

-"Cuerpos extraños en órbita [Foreign bodies in the orbit]". I European Congress of Videosurgery and II National Congress of Emergency Surgery, Barcelona, Spain (November 1987)

-"La RMN en los gliomas supratentoriales. Utilidad diagnóstica y comparación con la TC [MRI in supratentorial gliomas. Diagnostic use and comparison with CT]". XXVIII Anual Neurosurgical Symposium, Madrid, Spain (November 1987)

-"HSA recurrente: Atípica presentación de un neurinoma espinal [Recurrent SAH: Atypical presentation of a spinal neurinoma]". XXIX Meeting of the Luso-Spanish Society of Neurosurgery (Joint Meeing with the German Society), Zaragoza, Spain (October 1988)

-"Endotelinas y S.N.C. [Endothelins and CNS]". Servicio de Neurología, Hospital Universitario San Carlos, Madrid, Spain (July 1992)

-"Therapeutic effects of CDP-choline in Alzheimer´s disease and multi-infarct dementia". International Conference on Neurodegenerative Disease: New Approaches to treatment, Londres, UK (September 1992)

-"Tratamiento médico del accidente vascular cerebral [Medical therapy of the brain attack]". Inaugural Meeting of the Unidad Neurovascular del Centre Quirurgic Sant Jordi, Barcelona, Spain (March 1994)

-"El vasoespasmo en la hemorragia subaracnoidea [Vasospasm in SAH]". 1st Course on Neurovascular Pathology: Intracraneal Aneurysms. H.G.U. Vall d'Hebrón, Barcelona, Spain (April 1995) -"A novel theoretical model of cerebral vasospasm". 5th Meeting of the European Neurological Society, Munich, Germany (June 1995)

-"Fisiopatología del vasoespasmo cerebral [Pathophysiology of cerebral vasospasm]". III Course on ICP Monitoring and Cerebral Hemodynamics. Update on monitoring and treatment of neurocritrical patients. Servicio de Neurocirugía. Unidad de Neurotraumatología, Hospitals del Vall d’Hebrón, Barcelona, Spain (May 1996)

-"Una definición de deterioro cognitivo de origen vascular (DCV) [A definition of cognitive impairment of vascular origin]". X National Congress of the Spanish Society of Neurology, Tenerife, Spain (May 1996)

-"Isquemia cerebral [Brain Ischemia]". I Internacional Course on Vascular Neurosurgeryr. Servicio de Neurocirugía, Hospitals del Vall d’Hebrón, Barcelona, Spain (October 1996)

-"Comparación del IVP12 entre pacientes con deterioro cognitivo de origen vascular y tipo Alzheimer [Comparison of the PVI12 between patients with cognitive impairment of vascular origin and patients with Alzheimer’s disease]". XLVIII Annual Meeting of the Spanish Society of Neurology, Barcelona, Spain (December 1996)

-"Vasoespasmo [Vasospasm]". Course of Neurovascular Pathology 1997, Hospitals del Vall d’Hebrón, Barcelona, Spain (May 1997) -"Papel de las endotelinas en la hemorragia subaracnoidea [Role of endothelins in SAH]". IV Course on ICP Monitoring and Cerebral Hemodynamics, Hospitals del Vall d’Hebrón, Barcelona, Spain (June 1997)

-"Papel del a ET-1 en la fisiopatología del vasoespasmo cerebral post-hemorragia subaracnoidea (HSA) [Role of ET-1 in the pathophysiology of cerebral vasospasm alter SAH]". IV Congress of the Spanish Society of Neurosurgery, Burgos, Spain (May 1999) -"Ensayo clínico piloto, controlado, doble ciego, aleatorizado, de nicardipino frente placebo en pacientes afectos de traumatismo craneal grave o moderado [Pilot clinical trial, controlled, double-blind, and randomized of nicardipine versus placebo in patients with moderate to severe head injuries]". IV Congress of the Spanish Society of Neurosurgery, Burgos, Spain (May 1999)

-"Papel del a ET-1 en la fisiopatología del vasoespasmo cerebral post-hemorragia subaracnoidea (HSA) [Role of ET-1 in the pathophysiology of cerebral vasospasm alter SAH]". XI National Congress of the Spanish Society of Neurology, Santiago de Compostela, Spain (May 1999)

-"Double-blind clinical trial in phase III comparing the efficacy and safety of dotarizine and flunarizine in the prevention of migraine". 9th Congress of the International Headache Society, Barcelona, Spain (June 1999)

-"IVP-12: un método cuantitativo de valoración del deterioro cognitivo de origen vascular [PVI12: A quantitative method to assess

the cognitive impairment of vascular origin]", II National Conference on Alzheimer’s Disease, Bilbao, Spain (November 1999)

-"¿Puede detenerse la muerte celular programada o apoptosis en la isquemia cerebral? Papel neuroprotector de la citicolina en la isquemia cerebral [Can the apoptosis be stopped? Neuroprotectant role of citicoline in brain ischemia]", PIC 2000, VII Symposium on ICP Monitoring and Cerebral Hemodynamics, Hospitals del Vall d’Hebrón, Barcelona, Spain (November 2000)

-"Farmacología de citicolina [Pharmacology of citicoline]", Symposium on Neuronal Membrane and Citicoline in Stroke. IX Spanish Course of the American Neurological Academy, Miami, USA (November 2000)

-"Tratamiento del ictus y neuroprotección [Treatment of stroke and neuroprotection]", Scientific Meeting on Update in the Treatment of Acute Ischemic Stroke, Zamora, Spain (November 2000) -"A Composite Data Analysis of Citicoline in Acute Ischemic Stroke ", 126th Annual Meeting of the American Neurological Association, Chicago, USA (October 2001) -"Citicoline inhibits expression of procaspases and PARP in a model of focal cerebral ischemia", 126th Annual Meeting of the American Neurological Association, Chicago, USA (October 2001) -“Citicoline for the treatment of brain ischemia”, this lecture has been done more than 100 times in different countries worldwide -“Neuroprotection in the treatment of brain ischemia”, this lecture has been done more than 100 times in different scientific meetings worldwide -“Citicoline reduces caspase-3 activation and cell death induced by staurosporine in SH-SY5Y human neuroblastoma cells”, FENS Forum 2002, París, France (July 2002) -“Dose-dependent neuroprotective effects of citicoline in an experimental model of brain ischaemia”, 12th European Stroke Conference, Valencia, Spain (May 2003) -“Citicolina inhibe la liberación de glutámico incrementando los niveles de ATP cerebral en un modelo de isquemia cerebral focal en

ratas [Citicoline inhibits glutamate release by means of the increment of cerebral ATP in a model of focal cerebral ischemia in rats]”, LV Meeting of SEN, Barcelona, Spain (November 2003) -“Estudio piloto, doble-ciego, aleatorizado y controlado por placebo, de la eficacia y seguridad de citicolina en el tratamiento, en fase aguda, de la hemorragia intracerebral primaria (HIC) [Citicoline in intracerebral haemorrhage: a double-blind, randomized, placebo-controlled, multi-centre pilot study]”, LV Meeting of SEN, Barcelona, Spain (November 2003) -“Citicoline inhibits the extracellular glutamate accumulation after experimental ischemia by differentially targeting glutamate transport in neurons and astrocytes”. 13th European Stroke Conference, Mannhein, Germany (May 2004) -“The neuroprotectant citicoline targets glutamate release and uptake in neurons and astrocytes”, 4th Annual Meeting of the Society for Neuroscience, San Diego, CA, USA (October 2004) -“Citicoline: An evidence-based therapy for disorders related with brain ischemia”, this lecture has been done more than 50 times in different countries worldwide -“ICTUS study: International Citicoline Trial on acUte Stroke”, International Stroke Conference 2006, Kissimmee FL, USA (Feb 2006) -“A chronic treatment with CDP-choline increases neuronal plasticity and improves sensorimotor recovery after stroke”, 15th European Stroke Conference 2006, Brussels, Belgium (May 2006) -“Manejo del ACV isquémico agudo [Management of Acute Ischemic Stroke]”, Congress of the Venezuelan Society of Critical Medicine, Isla Margarita, Venezuela (June 2006) -“ICTUS study: International Citicoline Trial on acUte Stroke. Update 2007”, International Stroke Conference 2007, San Francisco CA, USA (Feb 2007) -“Cerebral Ischemia and Trauma - Different Etiologies, But Similar Mechanisms: Neuroprotective Opportunities” Vachira Phuket Hospital, Phuket, Thailand(March 2007).

-“Citicoline in the management of TBI” Annual Meeting of the Bulgarian Neurosurgical Society, Devin, Bulgaria (October 2007). -“ICTUS study: International Citicoline Trial on acUte Stroke. Update 2008”, International Stroke Conference 2008, New Orleans LA, USA (Feb 2008) - “Update on Neuroprotection” Sudak, Ukraine (April 2008) -“ICTUS Study: International Citicoline Trial on acUte Stroke (update 2008). A multicenter, prospective, randomized, double-blind, placebo-controlled study”, European Stroke Conference 2008, Nice (May 2008) - “Update on Neuroprotection” Odessa, Ukraine (October 2008) - “Update on Neuroprotection” Tiblisi, Georgia (October 2008) - “Update on Neuroprotection” Yeravan, Armenia (October 2008) - “Update on Neuroprotection” Baku, Azerbaiyan (October 2008) - “Regictus: registro prospectivo de ictus en hospitales españoles sin unidad de ictus [Regictus: Prospective registry of strokes in Spanish hospitals without stroke unit]” LX Annual Meeting of the Spanish Neurological Society, Barcelona (November 2008). - “Acute lesions of the CNS. Targets for Neuroprotection”, Academy of Filipino Neurosurgeons, Manila (December 2008) -“ICTUS study: International Citicoline Trial on acUte Stroke. Update 2009”, International Stroke Conference 2009, San Diego CA, USA (Feb 2009) -“ICTUS Study: International Citicoline Trial on acUte Stroke (update 2009). A multicenter, prospective, randomized, double-blind, placebo-controlled study”, European Stroke Conference 2009, Stockholm (May 2009) -“Efficiency in the design of clinical trials with ordinal scales” XII Conferencia Española de Biometría. Cádiz (Sep 2009)

-“ICTUS study: International Citicoline Trial on acUte Stroke. Update 2010”, International Stroke Conference 2010, San Antonio TX, USA (Feb 2010) - “Update on Neuroprotection”, Yangon, Myanmar (March 2010) -“ICTUS Study: International Citicoline Trial on acUte Stroke (update 2010). A multicenter, prospective, randomized, double-blind, placebo-controlled study”, European Stroke Conference 2010, Barcelona (May 2010) -“The number of strokes admission/year per hospital predicts the outcome”, European Stroke Conference 2010, Barcelona (May 2010) -“Update on neuroprotection”, International Course of Internal Medicine of North America, México DF (July 2010) -“Citicoline in the treatment of intracerebral hemorrhage”, 4th Western China International Neuroscience Forum, Tengchong, China (August 2010) -“Efficiency of stroke clinical trials with ordinal outcomes: a simulation study”, ISCB 2010, Montpellier (Sep 2010) -“Neuroprotection: Challenges & opportunities”, Phuket, Thailand (January, 2011) -“Neuroprotection: Challenges & opportunities”, Yangon, Myanmar (January, 2011) -“Neuroprotection: Challenges & opportunities”, ChiangMai, Thailand (January, 2011) -“Neuroprotection: Challenges & opportunities”, Bangkok, Thailand (January, 2011) -“Neuroprotection: Challenges & opportunities”, Thammasat University, Bangkok, Thailand (January, 2011) -“Neuroprotection: Challenges & opportunities”, Phuket, Thailand (February, 2011)

-“ICTUS study: International Citicoline Trial on acUte Stroke. Update 2011”, International Stroke Conference 2011, Los Angeles, USA (Feb 2011) -“ICTUS Study: International Citicoline Trial on acUte Stroke (update 2011). A multicenter, prospective, randomized, double-blind, placebo-controlled study”, European Stroke Conference 2011, Hamburg (May 2011) -“Neuroprotection: Challenges & opportunities”, Several meetings (2011) -“Citicoline in the treatment of intracerebral haemorrhage”. APSC 2011, Sri Lanka (October 2011) -“ICTUS study: International Citicoline Trial on acUte Stroke. Update 2012”, International Stroke Conference 2012, New Orleans, USA (Feb 2012) -“Citicoline Is A Strong Pro-angiogenic Molecule And Protects Brain Endothelial Cells From Apoptosis After Stroke”, International Stroke Conference 2012, New Orleans, USA (Feb 2012) -“Neuroprotection: Challenges & opportunities”, 3rd Congress of the Vietnamese Stroke Society, Hue, Vietnam (April 2012) -“Role of citicoline in neurorehabilitation”, Witoriya General Hospital, Yangon, Myanmar (April 2012) -“Final results of the International Citicoline Trial on acUte Stroke (ICTUS Study)”, European Stroke Conference, Lisbon, Portugal (May 2012) -“Acute Stroke Management. Role of Citicoline”, 1st Asia-Pacific Symposium on Stroke, Tokyo, Japan (September 2012)

-“Acute Stroke Management. Role of Citicoline”, Conference, San José, Costa Rica (November 2012) -“Role of citicoline in cognitive impairment”, Conference, San José, Costa Rica (November 2012) -“Acute Stroke Management. Role of Citicoline”, Conference, Santo Domingo, República Dominicana (November 2012)

-“Cognitive impairment”, XXVII Congreso Nacional de Neurología. Asociación Guatemalteca de Neurología. Antigua, Guatemala (November 2012)

-“Acute Stroke Management. Role of Citicoline”, XXVII Congreso Nacional de Neurología. Asociación Guatemalteca de Neurología. Antigua, Guatemala (November 2012) -“Acute Stroke Management. Role of Citicoline”, Symposium on Stroke. Kuala Lumpur, Malaysia (November 2012) -“Role of citicoline on the treatment of ischemic stroke: a formal and cumulative meta-analysis”, 7th World Congress on Controversies in Neurology. Istanbul, Turkey (April 2013) -“Update in neuroprotection treatment”, The Northern Neuroscience Center. Faculty of Medicine, Chiang Mai University, Thailand (April 2013)

-“Acute Stroke Management. Role of Citicoline”, London (May 2013) -“Acute Stroke Management. Role of Citicoline”, NDGD Hospital, HoChiMin City, Vietnam (August 2013) “Citicoline in the treatment of TBI. An update”, NDGD Hospital, HoChiMin City, Vietnam (August 2013) -“Acute Stroke Management. Role of Citicoline”, 2nd Asia-Pacific Symposium on Stroke, Hong Kong, China (August 2013) -“Acute Stroke Management. Role of Citicoline”, Casablanca, Morocco (September 2013)

-“Role of Citicoline in Neurorehabilitation”, Bakú, Azerbaijan (February 2014) -“Citicoline: An evidence-based therapy against brain ischemia”, Bangkok, Thailand (March 2014) -“Acute Stroke Management. Role of Citicoline”, 3rd Symposium on Stroke & Cognitive Impairment, Marrakech, Morocco (April 2014)

-“Acute Stroke Management. Role of Citicoline”, Kuwait (April 2014)

-“Citicoline: An evidence-based therapy against brain ischemia”, Amman, Jordan (May 2014) -“Acute Stroke Management. Role of Citicoline”, Nize, France (May 2014) -“Acute Stroke Management. Role of Citicoline”, Seoul, South Korea (May 2014) -“Acute Stroke Management. Role of Citicoline”, Pusan, South Korea (May 2014) -“Acute Stroke Management. Role of Citicoline”, International scientific-practical conference "Actual problems of neurology", dedicated to the 80th anniversary of the Nervous Diseases Department, carried out within "125 years of S.D. Asfendiyarov. Almaty, Kazakhstan (6-7 June 2014) -“Acute Stroke Management. Role of Citicoline”, National Conference of Neurology, Varna, Bulgaria (12-15 June 2014) -“Acute Stroke Management. Role of Citicoline”, 3rd Asia-Pacific Symposium on Stroke and Cognitive Impairment, Siam Reap, Cambodia (7 July 2014)

-“Citicoline An evidence based treatment”, Accra, Ghana (15 July 2014) -“Citicoline An evidence based treatment”, Dar Es Salaam, Tanzania (18 July 2014) -“Citicoline An evidence based treatment”, Several conferences in CenterAmerica (1-15 September 2014) -“Citicoline An evidence based treatment”, Santiago, Dominican Republic (16 September 2014) -“Citicoline An evidence based treatment”, Quito, Ecuador (29 September 2014)

-“Citicoline An evidence based treatment”, Guayaquil, Ecuador (30 September 2014) -“Role of citicoline on neurorehabilitation”, Asuncion, Paraguay (2 October 2014) -“Role of Citicoline mild vascular cognitive impairment”, Gabala, Azerbaijan (18 October 2014) -“Hospital and Post-hospital Management of Stroke”, Yangoon, Myanmar (15 November 2014) -“Acute Stroke Management. Role of Citicoline”, PNA annual meeting, Manila, Philippines (22 November 2014) -“Citicoline An evidence based treatment”, Manila, Philippines (26 November 2014) -“Role of Citicoline mild vascular cognitive impairment”, Dead Sea, Jordan (11 December 2014) -“Citicoline on TBI”, Tashkent, Uzbekistan (12 January 2015) -“Citicoline An evidence based treatment”, Tashkent, Uzbekistan (13 January 2015) -“Citicoline An evidence based treatment”, Samarkand, Uzbekistan (15 January 2015) -“Citicoline on TBI”, Alexandria, Egypt (17 March 2015) -“Citicoline: An evidence-based therapy against brain ischemia”, 16th CNC - Cairo International Neurology Conference. Cairo, Egypt (18 March 2015) -“Citicoline on TBI”, Cairo, Egypt (19 March 2015) -“Citicoline: An evidence-based therapy against brain ischemia”, Cairo, Egypt (21 March 2015)

-“Citicoline: Rationale for a biochemical approach against Brain Ischemia Related Disorders”, 4th Symposium Stroke & Cognitive impairment. Rome, Italy (23 April 2015) -“Pre-clinical and clinical data on citicoline (Ceraxon) as a gold standard of evidence-based medicine”, Izhevsk, Russia (12 May 2015) -“Citicoline (Ceraxon): From neuroprotection to neuroplasticity: Neurorehabilitation after stroke and TBI”, Izhevsk, Russia (12 May 2015) -“Citicoline: Rationale for a biochemical approach against Brain Ischemia Related Disorders”, 4th Asia-Pacific Symposium Stroke & Cognitive impairment. Bangkok, Thailand (29 June 2015) -“Citicoline: Rationale for a biochemical approach against Brain Ischemia Related Disorders”, 3rd LatinAmerican Symposium Stroke & Cognitive impairment. Miami, USA (23 July 2015) -“Acute Stroke Management-Role of Citicoline”. Bishkek, Kyrgyzstan (19 August 2015) -“Citicoline: Rationale for a biochemical approach against Brain Ischemia Related Disorders”, Advisory Board for Neuroprotection in Kyrgyzstan. Bishkek, Kyrgyzstan (20 August 2015) - “Citicoline on TBI”, III International Congress of Neurological Surgeons of Kyrgyzstan. Cholpon-Ata, Kyrgyzstan (21-22 August 2015) -“Citicoline: Rationale for a biochemical approach against Brain Ischemia Related Disorders”, Tashkent, Uzbekistan (24 August 2015) -“Citicoline: Rationale for a biochemical approach against Brain Ischemia Related Disorders”, Bukhara, Uzbekistan (25 August 2015) -“Citicoline: Rationale for a biochemical approach against Brain Ischemia Related Disorders”, Andijan, Uzbekistan (26 August 2015) -“Pathophysiology of Ischemic Brain Injury”, 15th Annual Conference of Ceerebrovascular Society of India, Neurovascon 2015, Ludhiana, India (20 September 2015)

-“Citicoline: An evidence-based therapy against brain ischemia”, Sharm El-Sheikh, Egypt (3 October 2015) -“Citicoline Rationale for a biochemical approach against Brain Ischemia Related Disorders”, Quito, Ecuador (26 October 2015) -“Citicoline Rationale for a biochemical approach against Brain Ischemia Related Disorders”, Cuenca, Ecuador (27 October 2015) -“Citicoline Rationale for a biochemical approach against Brain Ischemia Related Disorders”, Guayaquil, Ecuador (28 October 2015) -“Citicoline Rationale for a biochemical approach against Brain Ischemia Related Disorders”, Manta, Ecuador (26 October 2015) -“Pre-clinical and clinical data on citicoline (Ceraxon) as a gold standard of evidence-based medicine”, Ulyanovsk, Russia (2 November 2015) -“From neuroprotection to neuroplasticity - neurorehabilitation after stroke and TBI”, Ulyanovsk, Russia (2 November 2015) -“Pre-clinical and clinical data on citicoline (Ceraxon) as a gold standard of evidence-based medicine”, Tyumen, Russia (4 November 2015) -“From neuroprotection to neuroplasticity - neurorehabilitation after stroke and TBI”, Tyumen, Russia (4 November 2015) -“Role of citicoline in the management of TBI”. 5th MASSIN Congress. Dead Sea (Jordan) (13-14 November 2015). -“Pre-clinical and clinical data on citicoline (Ceraxon) as a gold standard of evidence-based medicine”, Khabarovsk, Russia (17 November 2015) -“From neuroprotection to neuroplasticity - neurorehabilitation after stroke and TBI”, Khabarovsk, Russia (17 November 2015) -“Pre-clinical and clinical data on citicoline (Ceraxon) as a gold standard of evidence-based medicine”, Belgorod, Russia (19 November 2015)

-“From neuroprotection to neuroplasticity - neurorehabilitation after stroke and TBI”, Belgorod, Russia (19 November 2015) -“Pre-clinical and clinical data on citicoline (Ceraxon) as a gold standard of evidence-based medicine”, Moscow, Russia (21 November 2015) -“From neuroprotection to neuroplasticity - neurorehabilitation after stroke and TBI”, Moscow, Russia (21 November 2015) -“Pre-clinical and clinical data on citicoline (Ceraxon) as a gold standard of evidence-based medicine”, Kemerovo, Russia (23 November 2015) -“From neuroprotection to neuroplasticity - neurorehabilitation after stroke and TBI”, Kemerovo, Russia (23 November 2015) -“Pre-clinical and clinical data on citicoline (Ceraxon) as a gold standard of evidence-based medicine”, Novokuznetsk, Russia (24 November 2015) -“From neuroprotection to neuroplasticity - neurorehabilitation after stroke and TBI”, Novokuznetsk, Russia (24 November 2015)

PUBLICATIONS

-"Ciatalgia en pacientes cirróticos por dilatación de los plexos venosos raquídeos [Low back pain in cirrhotic patients caused by the dilatation of rachideal venous plexus]". Rev Quir Esp, 13: 158-159, 1986

-"Hemorragia espontánea del cerebelo en el adulto. Análisis de 15 casos [Spontaneous Cerebellar Hemorrhage in Adults: Analysis of 15 cases]". Rev Neurol, 15: 56-64, 1987

-"Lesión craneocerebral por arma de fuego con evolución atípica. Caso clínico [Atipical evolution of a craneocerebral gunshot wound. Case report]". Neurocirugía, 1:305-308, 1990 -"Herida craneocerebral tangencial por arma de fuego. Caso clínico [Tangential craneocerebral gunshot wound. Case report]". Neurocirugía, 1:412-415, 1990

-"Traumatismos craneoencefálicos: Revisión fisiopatológica y terapéutica. Aportaciones de la CDP-colina [Head injuries: Review of its pathophysiology and therapeutics. Role of CDP-choline]". Excerpta Medica, Amsterdam, 1991 ISBN 9021999439, 9789021999432

-"Nicardipino en el tratamiento profiláctico de las cefaleas vasculares [Nicardipine in the prophylaxis of vascular headaches]". Rev Neurol, 20 (Supl.1): 35-43, 1992

-"Nuevo factor mitógeno en el plasma de pacientes urémicos y diabéticos [A novel mitogen factor in patients with diabetes and uremia]". Nefrología, 12(3): 278, 1992

-"Endothelins and the Central Nervous System". In R. Cacabelos ed.: Annals of Psychiatry: Basic and Clinical Neurosciences (vol. 3). Prous Science Publishers, Barcelona, 1992; pp: 379-399

-"Intracavernous cavernous hemangioma: An unpublished but reported case". Neurosurgery, 32(4): 693, 1993

-"Endothelin in migraine". Cephalalgia, 13(3): 218, 1993 -"CDP-colina: Perfil farmacológico y clínico [CDP-choline: Pharmacological and clinical profile]". Farmacoterapia, 11(3): 128-131, 1994

-"A novel theoretical model of cerebral vasospasm" J Neurol, 242 (Suppl.2): S76, 1995

-"CDP-choline: Pharmacological and clinical review". Methods Find Exp Clin Pharmacol, 17(Suppl.B): 1-54, 1995

-"CDP-colina y trastornos cognitivos [CDP-choline and cognitive disorders]". JM Costa Molinari ed.: Trastornos cognitivos en psicopatología. JR Prous ed., Barcelona, 1995

-"Endothelin receptor antagonists". En R. Cacabelos ed.: Annals of Psychiatry: Basic and Clinical Neurosciences (vol. 7). Prous Science Publishers, Barcelona, 1996; pp: 293-308

-"A new method for quantifying the cognitive impairment. Its application in patients with vascular dementia ". Neurología, 12: 339-342, 1997

-"Ensayo clínico experimental, doblemente ciego, aleatorizado, controlado con placebo, del efecto de nicardipino en la función cognitiva en pacientes afectos de demencia vascular [An experimental, randomized, double-blind, placebo-controlled clinical trial to investigate the effect of nicardipine on cognitive function in patients with vascular dementia. Spanish group of nicardipine study in vascular dementia]". Rev Neurol, 28: 835-845, 1999

-"Effects of citicoline on cognitive performance, brain bioelectrical activity and brain hemodynamics in Alzheimer’s disease patients: A double-blind, placebo-controlled study." Ann Psychiat, 7: 331-352, 1999 -"Double-blind clinical trial in phase III comparing the efficacy and safety of dotarizine and flunarizine in the prevention of migraine." Cephalalgia, 19: 375, 1999 -"Papel del a ET-1 en la fisiopatología del vasoespasmo cerebral post-hemorragia subaracnoidea (HSA) [Role of ET-1 in the pathophysiology of cerebral vasospasm after SAH]". Prous Science Editors, Barcelona, 1999

-"Double-blind placebo-controlled study with citicoline in APOE genotyped Alzheimer's disease patients. Effects on cognitive

performance, brain bioelectrical activity and cerebral perfusion". Methods Find Exp Clin Pharmacol, 21: 633-644, 1999

-"CDP-colina en el tratamiento del traumatismo craneoencefálico [CDP-choline in the treatment of head injuries]". Informaciones Psiquiátricas, 158: 371-380, 1999

-"Hemorragia subaracnoidea, isquemia cerebral y endotelina-1 [Subarachnoid hemorrhage, cerebral ischemia and endothelin-1]". Rev Neurol , 30: 27-34, 2000 -"Ensayo clínico piloto, controlado, doble ciego, aleatorizado, de nicardipino frente placebo en pacientes afectos de traumatismo craneal grave o moderado [A controlled, double-blind, randomized pilot clinical trial of nicardipine as compared with a placebo in patients with moderate or severe head injury]". Rev Neurol, 30: 401-408, 2000 -“Citicoline inhibits expression of procaspases and PARP in a model of focal cerebral ischemia” Ann Neurol, 50(Suppl 1): S13, 2001 -“A composite data analysis of citicoline in acute ischemic stroke” Ann Neurol, 50(Suppl 1):S13, 2001 -"CDP-choline: Update and review of its pharmacology and clinical use". Methods Find Exp Clin Pharmacol, 24(Suppl B): 1-53, 2002 -"CDP-choline reduces pro-caspase and cleaved caspase-3 expression, nuclear DNA fragmentation, and specific PARP-cleaved products of caspase activation following middle cerebral artery occlusion in the rat". Neuropharmacology, 42: 846-854, 2002 -"Oral citicoline in acute ischemic stroke: an individual patient data pooling analysis of clinical trials". Stroke, 33: 2850-2857, 2002 -“Fisiopatología del vasoespasmo cerebral en la hemorragia subaracnoidea: Qué es cierto? Qué es hipótesis? Qué es ilusión? [Pathophysiology of cerebral vasospasm in SAH. What is true? What is hypothesis? What is illusion?]” MIO, 2: 252-278, 2002

-“Citicoline increases glutathione redox ratio and reduces caspase-3 activation and cell death in staurosporine-treated SH-SY5Y human neuroblastoma cells” Brain Res, 957: 84-90, 2002 -“Neuroprotective effect of citicoline in 6-hydroxydopamine-lesioned rats and in 6-hydroxydopamine-treated SH-SY5Y human neuroblastoma cells” J Neurol Sci, 215: 105-110, 2003 -“Dose-dependent, neuroprotective effects of citicoline in an experimental model of brain ischemia” Cerebrovasc Dis, 16(Suppl 4): 101-102, 2003 -“Citicoline inhibits the extracellular glutamate accumulation after experimental ischemia by differentially targeting glutamate transport in neurons and astrocytes” Cerebrovasc Dis, 17(Suppl 5): 62, 2004 -“Citicoline in the treatment of traumatic brain injury” Drugs of Today, 40(Suppl B): 1-18, 2004 -“Neuroprotection afforded by prior citicoline administration in experimental brain ischemia: effects on glutamate transport” Neurobiol Dis, 18: 336-345, 2005 -“Citicoline in intracerebral haemorrhage: a double-blind, randomized, placebo-controlled, multi-centre pilot study”. Cerebrovasc Dis, 21(5-6): 380-385, 2006 -“A chronic treatment with CDP-choline increases neuronal plasticity and improves sensorimotor recovery after stroke”. Cerebrovasc Dis, 21 (Suppl 4): 82, 2006 -“CDP-choline: Update and review of its pharmacology and clinical use. Update 2006". Methods Find Exp Clin Pharmacol, 28(Suppl B): 1-56, 2006 -“ICTUS study: International Citicoline Trial on acUte Stroke (NCT00331890)”. Published on-line in The Lancet (06PRT3005DMc) -“Cost–effectiveness of citicoline versus conventional treatment in acute ischemic stroke”. Expert Rev Pharmacoeconomics Outcomes, 8: 151-157, 2008

-“Evaluation of a sequential global test of improved recovery following stroke as applied to the ICTUS trial of citicoline”. Pharm Stat, 8(2):136-149, 2009 -“Boosting the chances to improve stroke treatment”. Stroke, 41(3):e143-e150, 2010 -“Citicoline preclinical and clinical update 2009-2010”. Stroke, 42 (Suppl 1): s36-s39, 2011 -“Citicoline: pharmacological and clinical review, 2010 update”. Rev Neurol, 52(Suppl 2): s1-s62, 2011 -“Probably role of citicoline in stroke rehabilitation: review of the literature”. Rev Neurol, 54: 173-179, 2012 -“Citicoline in the treatment of acute ischaemic stroke: an international, randomised, multicentre, placebo-controlled study (ICTUS trial)”. Lancet, 380: 349-357, 2012 -“Citicoline induces angiogenesis improving survival of vascular/human brain microvessel endothelial cells through pathways involving ERK1/2 and insulin receptor substrate-1”. Vasc Cell. 2012 Dec 10;4(1):20. doi: 10.1186/2045-824X-4-20 -“Citicoline in the management of head injuries. A systematic review and meta-analysis of controlled clinical trials” Trabajos Distinguidos Neurología 3 (2013) 4-7 -“Towards Effective Neurorehabilitation for Stroke Patients” Int J Phys Med Rehabil 2014, 2:2 -“Citicoline for acute ischemic stroke. A systematic review and formal meta-analysis of randomized, double-blind and placebo-controlled trials” J Trauma Treat 2014, 4:1

-“Rationale for Citicoline” J Cerebrovasc Sci 2015, 2:88-90 -“ Mild Cognitive Impairment of vascular origin: Proposal for an empirical approach in primary care” Medical Research Archives 2015, Vol 2, No 6

RESEARCH WORKS

PARTICIPATION IN MULTICENTRE STUDIES (1983-1988): Nicardipine and stroke (Ferrer Internacional, S.A.). CDP-Choline in severe head injuries (Ferrer Internacional, S.A.). Parenteral Nimodipine in the prevention and treatment of vasospasm post-subarachnoid hemorrhage (Bayer). PREPARATION OF CLINICAL TRIALS AND EXPERIMENTAL STUDIES (1989-2012): Nicardipine in the treatment and prevention of cerebral vasospasm after subarachnoid hemorrhage. Comparative study versus nimodipine. Experimental, double-blind, randomized clinical trial, placebo-controlled, on the effect of nicardipine on the cognitive function in patients affected with vascular dementia. Controlled, double-blind, randomized clinical trial of nicardipine versus placebo in patients affected with severe head injuries. Study of the effects of CDP-Choline (1000 mg/d v.o.) on the cognitive function, cerebral bioelectrical activity and cerebral hemodynamics in oral and chronic administration (85 days) in patients with Alzheimer’s disease of medium/moderate degree. Controlled, double-blind study versus placebo. Comparative Phase III clinical trial between dotarizine and flunarizine in the prophylaxis of migraine. Double-blind, randomized and placebo-controlled study on the efficacy and safety of CDP-Choline in the treatment, in acute phase, of the ischemic stroke in the elderly. Double-blind, randomized and placebo-controlled pilot study of the effects of CDP-Choline in the post-traumatic subjective syndrome. Neurophysiologic and neuropsychologic assessment. Comparative, simple-blind, pilot clinical study and the safety and efficacy of nicardipine and nicardipine retard in elderly patients with sequelae of ischemic cerebral vascular accident. Effect of citicoline on neuronal apoptosis in a model of permanent focal cerebral ischemia in rat. Pilot study on citicoline in primary cerebral hemorrhage.

Citicoline’s neuroprotection mechanisms (battery of experiments). International Clinical Trial of Citicoline on Acute Stroke (ICTUS study). ADtect External Clinical Validation Multi-Centre Study in Spain. Calidad de vida en pacientes con demencia: Efecto del componente vascular y de la anosognosia [Quality of life in patients with dementia: Effects of vascular components and anosognosia]. PROTOCOLS PREPARED (Hospital Clínico, Barcelona, 1983-1989): Initial treatment of malignant gliomas with surgery, radiotherapy and chemotherapy. Diagnostic assessment and treatment of single cerebral metastases. Protocol of treatment with chemotherapy of multiple cerebral metastases. Spontaneous intracranial hemorrhages: Diagnosis and treatment. Treatment schedule of head injuries. Treatment of SAH. Antibiotic prophylaxis in Neurosurgery. Intraoperative echography in Neurosurgery. SURGICAL TECHNIQUES DEVELOPED (1983-1988): Surgical widening of the cervical channel. Surgical approaches of the orbit by the upper route. PATENTS (1989-20011): Use of CDP-Choline for the prophylactic treatment of cerebral ischemia (Application No. 2000000610). DOCTORAL THESIS

Member of the tribunal for the Doctoral Thesis “Adaptación transcultural y validación al español del cuestionario de calidad de vida Dermatology Life Quality Index (DLQI) [Transcultural adaptation and validation of the Spanish version of the Dermatology Life Quality Index (DLQI)]” by Adolfo García De Tiedra. Pharmacy School; University of Barcelona, 2009. Member of the tribunal for the Doctoral Thesis “La citicolina y el ejercicio físico revierten el déficit en la memoria de reconocimiento de objetos en ratas con daño cerebral traumático [Citicoline and physical exercise revert the deficit of the object recognition memory in rats with traumatic brain injury]” by Alejandra Jacotte Simancas. Psychilogy School; Autonomous University of Barcelona, January 2013. OTHER ACADEMIC ACTIVITIES Director of the Master Final Research Project “Efficiency of stroke clinical trials with ordinal outcomes: a simulation study” by Juan V Torres Martín. Mathematics and Statistics School; Department of Statistics and Operative Research; Polytechnical University of Barcelona, 2010 Director of the Master Final Research Project “Analysis of repeated measures in clinical trials: Study of the hypothermic effect of citicoline” by Jordi Blanch. Mathematics and Statistics School; Department of Statistics and Operative Research; Polytechnical University of Barcelona, 2010 Member of the Advisory Board of the National Journal of Neurology (ISSN 2227-0892) of Azerbaijan. Member of the Advisory Board of the Journal of Experimental and Integrative Medicine (ISSN 1309-4572). Member of the Advisory Board of the International Journal of Neurological Disorders & Interventions Member of the Advisory Board of the International Journal of Physical Therapy and Rehabilitation