CURRICULUM VITAE Joseph Cornelius Cleveland, Jr., M.D. · CURRICULUM VITAE . Joseph Cornelius Cleveland, Jr., M.D. Home Address: 9176 East Wesley Ave. Denver, Colorado 80231 (303)

CURRICULUM VITAE Joseph Cornelius Cleveland, Jr., M.D.

Home Address: 9176 East Wesley Ave. Denver, Colorado 80231 (303) 671-8129 Office Address: University of Colorado Anschutz Medical Center Cardiothoracic Surgery, C-310 12631 East 17th Avenue, Rm 6602 Aurora, CO 80045 E-mail: [email protected] Office: (303) 724-2799 Date of Birth: November 3, 1965 Place of Birth: Philadelphia, Pennsylvania Marital Status: Married – Kimberly K. Cleveland, November 23, 1990 Children: Joseph Cornelius Cleveland, III January 19, 1995 Jean-Paul Cleveland March 26, 1998 Professional Associate Professor Experience: Specialty: Cardiothoracic Surgery

University of Colorado Denver July 1, 2005- Present Assistant Professor Specialty: Cardiothoracic Surgery University of Colorado Health Sciences Center July 1, 2001- 2005

Chief, Cardiothoracic Surgical Service Denver Veterans Administration Medical Center 2001-Present Surgical Director, Adult Cardiac Transplantation/ Mechanical Cardiac Assist Devices University of Colorado Denver 2002-Present Associate Director of Thoracic Surgery Residency Program University of Colorado Denver 2003 – Present

Cleveland 1

Director Thoracic Surgery Residency Program University of Colorado Health Sciences Center 2002- 2003

Education Undergraduate: University of Southern California Los Angeles, California 1983-1987 B.S., Magna Cum Laude, Biological Sciences Medical School: University of Washington School of Medicine Seattle, Washington 1987-1991 M.D. with High Honors Postgraduate Medical Training: Internship, General Surgery University of Colorado Health Sciences Denver, Colorado 1991-1992 Resident, General Surgery University of Colorado Health Sciences Denver, Colorado 1992-1997 Chief Resident, General Surgery University of Colorado Health Sciences Denver, Colorado 1997-1998 Resident, Thoracic and Cardiovascular Surgery University of Colorado Health Sciences 1998- 2001 Research Experience: Medical Student Research Program, University of Washington Advisor: D. Scott Weigle, M.D. Department of Medicine, Division of Endocrinology Harborview Medical Center Seattle, Washington 1989-1991 Project: Satiety signals in rodent and primates National Institutes of Health (NIH) Trauma Surgical Research Fellowship Advisor: Alden H. Harken, M.D. Department of Surgery University of Colorado Health Sciences Center Denver, Colorado July 1994 – July 1996 Project: Cellular signaling during myocardial preconditioning Certification: National Board of Medical Examiners #400198 1992 Colorado Medical License #37633 1999

Cleveland 2

American Board of Surgery #44129 1999/2019 American Board of Thoracic Surgery #6611 2002/2012 Awards and Honors Undergraduate: Phi Beta Kappa May 1986 Mortar Board, University of Southern California May 1986 Blue Key, University of Southern California September 1987 Skull and Dagger, University of Southern California May 1987 Order of the Palm, University of Southern California May 1987 Medical School: Alpha Omega Alpha May 1990 (Junior Year) Medical School Research Program Honors Thesis, May 1991 Henry Harkins Award for Outstanding Medical Student in Surgery May 1991 Graduation with High Honors May 1991 Residency: Outstanding Intern of the Year, 1991- 1992 June 1992, University of Colorado Ben Eiseman Surgical Resident Research Award July 1997 Second Place, Resident Competition Colorado Chapter, American College of Surgeons, June 1997 First Place, Resident Competition Colorado Chapter, American College of Surgeons, June 1998 Professional Clifford Van Meter President’s Award, Southern Thoracic Surgical Assoc Awards: November 2001

Cleveland 3

Outstanding Clinical Teacher elected by the 3rd Year Medical Students 2002-2003

President’s Award for Leadership- Elected honor by the Medical Staff of The University of Colorado Hospital – December 2004

Professionalism Award. Recipient of the First Annual School of Medicine Faculty Senate Award UCDHSC July 2007 Co-recipient of the 5th Annual Dwight McGoon National Teaching Award Presented at the AATS Boston, MA, May 2009 Recognized by 5280: Denver’s Mile High Magazine as one of Denver’s Top Doctors, July 2010.

Protocols/Research/Clinical Studies

Awarded Academic Enrichment Fund $35,000 PI Joseph Cleveland Jr., MD, 2002 A Phase II, Multi-Center, Placebo-Controlled

Study:Clinical Pharmacology of Zoniporide $338,000 PI Joseph Cleveland Jr., MD, 2003

Quintiles, Inc Expedition Trial HOE642/3002 $100,133 PI Joseph Cleveland Jr., MD, 8/2001-1120/03

A Phase II randomized multi-center clinical study To evaluate the safety and efficacy of the Tandem Heart pVAD system vs conventional therapy CO-PI Joseph Cleveland Jr., MD 7/2003-7/2005 BVS 5000 Bivad Animal Implantation # 65405700 (11) 1B Transfer of Animal Protocol from ABIOMED Cardiovascular Inc PI Joseph C. Cleveland Jr. MD 07/2001 – 07/2004 Heartmate LVAS Destination Therapy Registry (National) Local P.I Joseph Cleveland Jr., MD, 8/1/2003 – Present $3,780 Jahnigen Career Development Award; The Effect of Age Upon Myocardial Cytokine Production. The Hartford Foundation 7/2004 - 6/2007 PI Joseph Cleveland, Jr., MD, $200,000 Cooperative Studies Program (CSP #517) – ROOBY study Outcomes following myocardial revascularization: On and off cardiopulmonary Bypass.

Denver VAMC PI Joseph Cleveland , Jr., MD 04/2002- 04/2008 $660,000

Cleveland 4

Multi-center, Randomized, Double-Blind, Parallel-group, Placebo-Controlled Study of Infusion of Pexelizumab in Patients Under going Coronary Artery Bypass Grafting with Cardiopulmonary Bypass (PRIMO-CABG II) Joseph C. Cleveland Jr., MD 10/2004- 11/2006 $130,000 Paracor Heartnet PEERLESS HF Trial (Paracor funded) CO-PI Joseph C. Cleveland, Jr., MD 07/2003 - 2008 $552,000

Member of Data Safety Monitoring Board for SYM-05-001 study sponsored by Symphony Medical, Inc, entitled “An open label study to demonstrate the safety of CM-1 use on the cardiac fat pad in pts undergoing open-heart CABG, mitral valve replacement or aortic valve replacement” 03/2006 – 05/2007

“A Study of the Evalve®Cardiovascular Valve Repair System (CVRS) Endovascular Valve Edge-to-Edge Repair Study”. PI John Carroll, M.D. CO-PI Joseph C Cleveland Jr., MD 07/2003- Present

Evaluation of the HeartWare Left Ventricular Assist Device for the Treatment of Advanced Heart Failure 01/2010 Present PI Joseph C. Cleveland Jr., MD CO-PI Andreas Brieke, MD $107,000

Society Memberships/Appointments:

American College of Cardiology, Member #619984 1998-Present Association for Academic Surgery, Member 1998-Present American Physiological Society, Member 1998-Present American Association for the Advancement of Science, Member 1997-Present Faculty Senate Representative for Department of Surgery 2002-2004 University of Colorado at Denver School of Medicine American College of Surgeons, Fellow #03035101 2003-Present The Society of Thoracic Surgeons, Member #112783 2003-Present Denver Academy of Surgery, Member 2003-Present Society of Critical Care Medicine, Member #36362 2003-Present American College of Chest Physicians, Member #228286 2004-Present American College of Cardiology, Fellow 2004-Present Heart Failure Society of America 2003-Present International Society of Heart and Lung Transplantation 2004-Present The Western Thoracic Surgical Association, Member #48124 2004-Present OPTN/UNOS National Lung Review Board, Alternate Member 2005-2006 The Society of Thoracic Surgeons Leadership:

Workforce on Clinical Trials 2004-2007 Workforce on Aging 2006-Present Workforce on Surgical Treatment of End-Stage

Cardiopulmonary Disease 2006-Present

Cleveland 5

Program Task Force/Planning Committee 2006-2009 Task Force on Quality Initiatives 2008-Present Workforce on Nomenclature and Coding 2011-Present Workforce on National Databases 2011-Present

Invited Member Risk Management UCDHSC Sentinel Event Task Force 2006-Present Expert Witness 2005-Present American Society of Transplant Surgeons 2006-Present American Geriatric Society, Member # 079244

Committee on Aging and Surgical Specialties 2006-Present Chair, Program Committee for Surg. Specialties 2008-2009

UNOS Region 8 Heart Review Board 2005-Present Donor Alliance Medical Advisory Board 2007-Present National Institute on Aging, Invited Panel Member 2007-Present

Medical Advisory Board Essential Pharmaceuticals 2007-Present Western Thoracic Surgical Association Program Committee 2008-Present Chair, Program Committee 2008-2009 Society of University Surgeons, Member #2006 2008-Present University of Colorado at Denver School of Medicine American Heart Association, Member 2008-Present UCD Faculty Promotions Committee 2009-Present RUC Committee Panel (AMA). Requested by the STS to provide testimony regarding CPT codes for VADs. Chicago, IL April 2009 October 2010 American Association for Thoracic Surgery, Member #48124 May 2009 American College of Cardiology/ACCF Council on Cardiovascular Care for Older Adults 2010- 2013 INTERMAC® (National database) Adverse Events & Adjudication Committee Reviewer 2010-Present UCD Faculty Professionalism Award Selection Committee 2010-Present American Medical Association 2011-Present STS Representative to AMA Physician Consortium for 2011-Present Performance Improvement (PCPI) Elected member of the Medical Board, University of Colorado Hospital 2011-Present

UCD School of Medicine Professionalism Committee 2011-Present Thoracic Committee member (national division) for UNOS Region Eight Representative 2011-Present Editorial Reviewer The Annals of Thoracic Surgery 2003-Present

Journal of Thoracic and Cardiovascular Surgery 2004-Present Diabetes 2001-Present

Heart 2005-Present Journal American College of Surgeons 2004-Present Journal American College of Cardiology 2004-Present

Cleveland 6

Journal of Critical Care 2004-Present American Journal of Physiology; Heart and Circulatory Physiology 2002-Present American Heart Journal 2006-Present Journal of Surgical Research 2005-Present Circulation 2005-Present Guidelines Reviewer Reviewer, 2011 ACCF/AHA Focused Update of the Guidelines for 2011 the Management of Patients with Unstable Angina/NSTEMI Editorial Board Journal of Surgical Research 2008-Present Abstract Reviewer Society of Thoracic Surgeons Annual Meeting 2008-2012

American Transplant Congress Conferences ` 2009-2010 American Transplant Congress Conferences 2010-2011 Editorial Reviewer The Annals of Thoracic Surgery 2003-Present

Journal of Thoracic and Cardiovascular Surgery 2004-Present Diabetes 2001-Present

Heart 2005-Present Journal American College of Surgeons 2004-Present Journal American College of Cardiology 2004-Present Journal of Critical Care 2004-Present American Journal of Physiology; Heart and Circulatory Physiology 2002-Present American Heart Journal 2006-Present Journal of Surgical Research 2005-Present Circulation 2005-Present Editorial Board Journal of Surgical Research 2008-Present Publications:

1. Wilson BE, Meyer GE, Cleveland JC Jr, Weigle DS. Identification of candidate genes for a factor regulating body weight in primates. Am J Physiol 1990; 259: R1148-R1155.

2. Rowland RT, Cleveland JC Jr, Meng X, Harken AH, Brown JM. Potential gene

therapy strategies in the treatment of cardiovascular disease. Ann Thor Surg 1995; 60: 721-728.

3. Rehring TF, Friese RS, Cleveland JC Jr, Gamboni-Robertson F, Banerjee A, Harken

AH. Specific isoforms of protein kinase C are associated with limitation of ischemic acidosis in the preconditioned heart. Surgical Forum 1995; Vol XLVI: 216-218.

Cleveland 7

4. Lindenfeld J, Shakar S, Zamora MR, Cook CD, Wolfel EE, Lowes BD, Ireland N, Keller K, Frisk R, Stepien L, Cleveland JC Jr, Zolty R. BOOP is common in cardiac transplant recipients switched from a calcineurin inhibitor to sirolimus. Am J of Transplantation 2005, Vol 5(issue 6), 1392-1396.

5. Cleveland JC Jr, Meldrum DR, Rowland RT, Banerjee A, Harken AH. Optimal

myocardial preservation: cooling, cardioplegia, and conditioning. Ann Thor Surg 1996; 61: 760-768.

6. Meldrum DR, Cleveland JC Jr, Rowland RT, Sheridan BC, Banerjee A, Harken AH.

Cardiac surgical implications of calcium dyshomeostasis in the heart. Ann Thor Surg, 1996; 61: 1273-1280.

7. Cleveland JC Jr, Meldrum DR, Rowland RT, Sheridan BC, Banerjee A, Harken AH.

The obligate role of protein kinase C in mediating clinically accessible cardiac preconditioning. Surgery, 1996; 120: 345-353.

8. Cleveland JC Jr, Wollmering MM, Meldrum DR, Rowland RT, Rehring TF, Sheridan

BC, Harken AH, Banerjee A. Ischemic preconditioning in human and rat ventricle. Am J Physiol 1996; 271: H1786-H1794.

9. Sheridan BC, McIntyre RC Jr, Meldrum DR, Cleveland JC Jr, Agrafojo JA, Eisenach

JH, Harken AH, Fullerton DA. Antibody mediated neutrophil depletion preserves pulmonary vasomotor dysfunction. J Surg Res, 1996; 62: 74-78.

10. Sheridan BC, McIntyre RC Jr, Meldrum DR, Cleveland JC Jr, Agrafojo JA, Banerjee

A, Harken AH, Fullerton DA. Microtubules regulate pulmonary vascular smooth muscle contraction. J Surg Res, 1996; 62: 284-287.

11. Meldrum DR, Cleveland JC Jr, Rowland RT, Banerjee A, Harken AH. Calcium

induced inotropy is in part mediated by protein kinase C. J Surg Res, 1996; 63: 400-405. 12. Rowland RT, Cleveland JC Jr, Meng X, Ao L, Harken AH, Brown JM. A single

endotoxin challenge induces delayed myocardial protection against infarction. J Surg Res, 1996; 63: 193-198.

13. Sheridan BC, McIntyre RC Jr, Meldrum DR, Cleveland JC Jr, Agrafojo JA, Eisenach

JH, Fullerton DA. Vinblastine attenuates endotoxin-induced impairment of cGMP- mediated pulmonary vasorelaxation. Shock, 1996; 6: 35-38.

14. Meldrum DR, Cleveland JC Jr, Mitchell MB, Sheridan BC, Gamboni-Robertson F,

Harken AH, Banerjee A. Protein kinase C mediates calcium induced cardioadaptation to ischemia-reperfusion injury. Am J Physiol, 1996; 271: R718-R726.

Cleveland 8

15. Meldrum DR, Cleveland JC Jr, Sheridan BC, Rowland RT, Banerjee A, Harken AH. Cardiac preconditioning with calcium: clinically accessible myocardial protection. J Thorac Cardiovasc Surg 1996; 112: 778-786.

16. Meng X, Cleveland JC Jr, Rowland RT, Mitchell MB, Brown JM, Banerjee A, Harken

AH. Norepinephrine – induced sustained myocardial adaptation to ischemia is dependent on alpha – one – adrenoceptors and protein synthesis. J Mol Cell Cardiol, 1996; 28: 2017-2025.

17. Rehring TF, Friese RS, Cleveland JC Jr, Banerjee A, Harken AH. Alpha-adrenergic

preservation of myocardial pH during ischemia is cPKC isoform dependent. J Surg Res, 1996; 63: 324-327.

18. Banerjee A, Gamboni-Robertson F, Mitchell MB, Rehring TF, Butler K, Cleveland JC

Jr, Meldrum DR, Shapiro JI, Meng X. Stress induced cardioadaptation reveals a code linking hormone receptors and spatial redistribution of PKC isoforms. Ann NY Acad Sci, 1996; 793: 226-239.

19. Meldrum DR, Cleveland JC Jr, Mitchell MB, Rowland RT, Banerjee A, Harken AH.

Constructive priming of myocardium against ischemia-reperfusion injury. Shock, 1996; 6: 238-242.

20. Meldrum DR, Cleveland JC Jr, Sheridan BC, Rowland RT, Banerjee A, Harken AH.

Differential effects of adenosine preconditioning on the post-ischemic rat myocardium. J Surg Res 1996; 65: 159-164.

21. Fullerton DA, Sheridan BC, Meldrum DR, Cleveland JC Jr, Agrafojo J, Harken AH,

McIntyre RC Jr. Neutrophils mediate pulmonary vascular smooth muscle dysfunction in acute lung injury. Surg Forum 1996; Vol XLVII, 328- 330.

22. Meldrum DR, Cleveland JC Jr, Sheridan BC, Banerjee A, Harken AH. The alpha and

beta isoforms of protein kinase C mediate the cardiac contractile response to exogenous calcium. Surg Forum 1996; Vol XLVII, 300-303

23. Cleveland JC Jr, Meldrum DR, Rowland RT, Sheridan BC, Fullerton DA, Butler K,

Banerjee A, Harken AH. Adenosine preconditioning of human myocardium is mediated through Potassium-ATP channel activation. Surg Forum 1996; Vol XLVII.

24. Meldrum DR, Sheridan BC, Cleveland JC Jr, Fullerton DA, Banerjee A, Harken AH.

Neutrophils are required for endotoxin-induced myocardial cross tolerance to ischemia-reperfusion. Arch Surg, 1996; 131: 1203-1208.

25. Meldrum DR, Cleveland JC Jr, Meng X, Sheridan BC, Banerjee A, Harken AH.

Hemorrhage induces acute cardioadaptation to ischemia-reperfusion by an alpha-one adrenoceptor mediated, protein synthesis independent mechanism. Am J Physiol 1997; 272: R718-R725.

Cleveland 9

26. Cleveland JC Jr, Meldrum DR, Harken AH, Banerjee A. Ischemic preconditioning of

human myocardium: protein kinase C mediates a permissive role for alpha-one adrenoceptors (abstract). Circulation 1996; 94(supplement I) I-114.

27. Meldrum DR, Cleveland JC Jr, Butler KL, Mitchell MB, Gamboni F, Meng X,

Banerjee A. Exogenous Calcium stimulated preconditioning of rat hearts is mediated by PKC (abstract). J Mol Cell Cardiol 1996; 28: A189.

28. Meldrum DR, Cleveland JC, Jr., Fullerton DA, Banerjee A, Harken AH. Neutrophils

are required for endotoxin-induced myocardial cross-tolerance to ischemia-reperfusion injury. Arch Surg 1996;131:1203-8.

29. Meldrum DR, Cleveland JC, Jr., Sheridan BC, Rowland RT, Banejee A, Harken AH.

Cardiac surgical implications of calcium dyshomeostasis in the heart. Ann Thorac Surg 1996;61:1273-80.

30. Cleveland JC, Jr., Meldrum DR, Rowland RT, Banerjee A, Harken AH.

Preconditioning and hypothermic cardioplegia protect human heart equally against ischemia. Ann Thorac Surg 1997;63:147-152.

31. Rehring TF, Bender PR, Cairns CB, Joo K, Friese RS, Shapiro JI, Cleveland JC, Jr.,

Banerjee A. Different preconditioning stimuli invoke disparate electromechanical and energetic responses to global ischemia in rat hearts. Can J Physiol Pharmacol 1997;75:335-342.

32. Cleveland JC Jr, Meldrum DR, Rowland RT, Meng X, Gamboni-Robertson F,

Banerjee A, Harken AH. Ischemic preconditioning of human myocardium: protein kinase C mediates a permissive role for alpha-one adrenoceptors. Am J Physiol, 1997; 273: H902-H908.

33. Cleveland JC Jr, Meldrum DR, Cain BS, Banerjee A, Harken AH. Oral sulfonylurea

hypoglycemic agents prevent ischemic preconditioning in human myocardium. Circulation, 1997; 96: 29-32.

34. Winter CB, Cleveland JC Jr, Butler KL, Bensard DD, Mitchell MB, Harken AH,

Banerjee A. Facilitative interactions between noradrenergic and purinergic signaling during preconditioning of the rat heart. J Mol Cell Cardiol, 1997; 29: 163-173.

35. Cleveland JC Jr, Meldrum DR, Rowland RT, Banerjee A, Harken AH. Adenosine

preconditioning of human myocardium is dependent upon the ATP-sensitive potassium channel. J Mol Cell Cardiol, 1997; 29: 175-182.

36. Meldrum DR, Cleveland JC Jr, Meng X, Sheridan BC, Gamboni F, Harken AH,

Banerjee A. Protein kinase C isoform diversity in preconditioning. J Surg Res, 1997; 69: 183-187.

Cleveland 10

37. Meldrum DR, Cleveland JC Jr, Sheridan BC, Rowland RT, Selzman CH, Banerjee A,

Harken AH. Alpha-adrenergic activation of myocardial NF Kappa B during hemorrhage. J Surg Res, 1997; 69: 268-276.

38. Rowland RT, Meng X, Cleveland JC Jr, Meldrum DR, Harken AH, Brown JM. LPS-

induced delayed myocardial adaptation enhances acute preconditioning to optimize post-ischemic cardiac function. Am J Physiol, 1997; 272: H2708-H2715.

39. Rehring TF, Bender PR, Cairns CB, Joo K, Friese RS, Shapiro JI, Cleveland JC Jr,

Banerjee A. Alpha–one adrenergic cardiac preconditioning attenuates ischemic acidosis and promotes proton extrusion in the rat. Can J Physiol Pharmacol, 1997; 71: 335-342.

40. Rowland RT, Meng X, Cleveland JC Jr, Meldrum DR, Harken AH, Brown JM.

Cardioadaptation induced by cyclic ischemic preconditioning is mediated by translational regulation of de nove protein synthesis. J Surg Res, 1997; 71: 155-160.

41. Meldrum DR, Cleveland JC Jr, Rowland RT, Banerjee A, Harken AH, Meng X. Early

and delayed preconditioning: differential mechanisms and additive protection. Am J Physiol, 273: H725-H733.

42. Cain BS, Meldrum DR, Selzman CH, Cleveland JC Jr, Meng X, Sheridan BC,

Banerjee A, Harken AH. Surgical implications of vascular endothelial physiology. Surgery, 1997; 122: 516-526.

43. Cain BS, Meldrum DR, Selzman CH, Cleveland JC Jr, Banerjee A, Harken AH. The

alpha and beta isoforms of PKC mediate the human myocardial contractile response to exogenous calcium. Surg Forum, 1997; XLVIII: 335-337.

44. Meldrum DR, Cleveland JC Jr, Moore EE, Partrick DA, Banerjee A, Harken AH.

Adaptive and maladaptive mechanisms of cellular priming. Ann Surg, 1997; 226: 587-598.

45. Meldrum DR, Cain BS, Cleveland JC Jr, Meng X, Ayala A, Banerjee A, Harken AH.

Adenosine decreases post-ischemic cardiac TNF-alpha production: anti-inflammatory implications for preconditioning and transplantation. Immunology, 1997; 92: 472-477.

46. Meldrum DR, Dinarello CA, Cleveland JC Jr, Shapiro L, Sheridan BC, Harken AH.

P38 MAP Kinase mediates myocardial ischemia-reperfusion injury: improved post-ischemic recovery with SB 203580 (Cytokine Suppressor Anti-Inflammatory Drug; CSAID). Surg Forum, 1997; XLVIII.

47. Meldrum DR, McIntyre RC Jr, Sheridan BC, Cleveland JC Jr, Fullerton DA, Harken

AH. L-arginine decreases alveolar macrophage proinflammatory monokine production during acute lung injury by a nitric oxide synthase-dependent mechanism. J Trauma, 1997; 43: 888-893.

Cleveland 11

48. Meldrum DR, Dinarello CA, Shames BD, Cleveland JC Jr., Cain BS, Banerjee A,

Meng X, Harken AH. Ischemic preconditioning decreases postischemic myocardial tumor necrosis factor-alpha production. Circulation 1998;98:II214-II219.

49. Meldrum DR, Cleveland JC Jr, Meng X, Cain BS, Banerjee A, Harken AH. Increased

myocardial TNF-alpha in a crystalloid perfused model of cardiac ischemia-reperfusion injury. Ann Thor Surg, 1998; 65: 439-443.

50. Cleveland JC Jr, Meldrum DR, Cain BS, Banerjee A, Harken AH. Reply to letter to

editor: Oral sulfonylurea hypoglycemic agents prevent ischemic preconditioning in human myocardium. Circulation, 1998; 97: 1427-1428.

51. Meldrum DR, Dinarello CA, Cleveland JC Jr, Cain BS, Shames BD, Meng X, Harken

AH. Hydrogen peroxide induced tumor necrosis factor alpha mediated cardiac injury by a P38 mitogen activated protein kinase dependent mechanism. Surgery, 1998; 124: 291-296.

52. Cain BS, Meldrum DR, Joo KS, Wang J, Meng X, Cleveland JC Jr, Banerjee A,

Harken AH. Human SERCA2a levels correlate inversely with age and may explain diastolic dysfunction in senescent human myocardium. JACC, 1998; 32: 458-467.

53. Rehring TF, Shapiro JI, Cain BS, Meldrum DR, Cleveland JC Jr, Harken AH, Banerjee

A. Mechanisms of pH preservation during global ischemia in preconditioned rat hearts: roles for PKC and NHE. Am J Physiol, 1998; 275: H805-H813.

54. Meldrum DR, Cleveland JC Jr, Cain BS, Shames BD, Banerjee A, Meng X, Harken

AH. Ischemic preconditioning decreases post-ischemic myocardial tumor necrosis factor alpha production: potential ultimate effector mechanism of preconditioning. Circulation, 1998; 98(19 suppl): II218-II219.

55. Meldrum DR, Cain BS, Meng X, Cleveland JC Jr, Shames BD, Donahoo KK,

Banerjee A, Harken AH. Calcium preconditioning but not ischemic preconditioning bypasses the adenosine triphosphate-dependent potassium (KATP) channel. J Surg Res, 1999; 85: 77-82.

56. Cain BS, Meldrum DR, Cleveland JC Jr., Meng X, Banerjee A, Harken AH. Clinical

L-type Ca (2+) channel blockade prevents ischemic preconditioning of human myocardium. J Mol Cell Cardiol 1999;31:2191-2197.

57. Pomerantz BJ, Joo K, Shames BD, Cleveland JC Jr, Banerjee A, Harken AH.

Adenosine preconditioning reduces both pre and post ischemic arrhythmias in human myocardium. J Surg Res, 2000; 90: 191-196.

Cleveland 12

58. Pomerantz BJ, Cleveland JC Jr, Garlid K, Banerjee A, Harken AH. Adenosine mediated cardiac preconditioning extends beyond opening of the mitochondrial KATP channel in human myocardium. J Surg Res 2000;90:191-196.

59. Rowland RT, Cleveland JC Jr., Upadhya P, Harken AH, Brown JM. Transportation or

noise is associated with tolerance to myocardial ischemia and reperfusion injury. J Surg Res 2000;89:7-12.

60. Cain BS, Meldrum DR, Cleveland JC Jr, Meng X, Banerjee A, Harken AH. L-type

calcium channel blockers inhibit myocardial preconditioning. J Mol Cell Cardiol, 2000: 32: 861-862.

61. Plomondon ME, Cleveland JC Jr, Ludwig S, Grunwald G, Werking DH, Grover FL,

Shroyer AL. Impact of off-pump coronary artery bypass graft procedures upon risk-adjusted outcomes at experienced centers. Ann Thor Surg, 2001;72:114-119.

62. Cleveland JC Jr., O’Brien MM, Shroyer AL, Grover FL. Impact of graft ischemic time

on outcomes after lung transplantation. Ann Thorac Surg 2000;69:1986. 63. Pomerantz BJ, Cleveland JC Jr, Olsen HK, Pomerantz M. Pulmonary resection for

multi-drug resistant tuberculosis. J Thorac Cardiovasc Surg, 2001;121:448-453. 64. Raeburn CD, Cleveland JC Jr, Selzman CH, Harken AH. Preconditioning in

myocardial revascularization. J Card Surg, 2000, in press. 65. Cleveland JC Jr, Raeburn C, Harken AH. Clinical applications of ischemic

preconditioning: L from head to toe. Surgery, 2001;129:664-667. 66. Cleveland JC Jr, Shroyer AL, Chen A, Peterson E, Grover FL. Off-pump coronary

artery bypass grafting significantly decreases risk-adjusted mortality and morbidity. Ann Thor Surg 2001;72:1282-1289.

67. Grover FL, Shroyer AL, Cleveland JC Jr., Hammermeister K. A decade’s experience

with quality improvement in cardiac surgery using the Veterans Affairs and Society of Thoracic Surgeons national databases. Ann Surg 2001;234:464-472.

68. Plomondon ME, Cleveland JC Jr, Shann LT, Grunwald GK, Kiefe CI, Grover FL,

Shroyer AL. Off-pump coronary artery bypass is associated with improved risk-adjusted outcomes. Ann Thor Surg, 2001;72:114-119.

69. Raeburn CD, Cleveland JC Jr, Zimmerman MA, Harken AH. Organ preconditioning.

Archives of Surgery 2001;136:1263-1266. 70. Grover FL, Cleveland JC Jr, Shroyer LW. Quality Improvement in Cardiac Care.

Archives of Surgery 2002;137:28-36.

Cleveland 13

71. Asano K, Bohlmeyer T, Westcott JY, Zisman LS, Kinugawa K, Good, M Minobe WA, Roden RL, Wolfel EE, Lindenfeld J, Port DJ, Perryman MB, Cleveland J, Lowes BD, Bristow MR. Altered expression of endothelin receptors in failing human left ventricles. Journal of Molecular and Cellular Cardiology 2002;34:833-46.

72. Stefka J, Cleveland JC, Lucia S, Singh M. Sarcomatoid intracardiac metastasis of a

testicular germ cell tumor closely resembling primary cardiac sarcoma. Case Study. Human Path 2003;34(10)1074-1077.

73. Grazia TJ, Hodges TN, Cleveland JC, Sheridan BC, Zamora MR. Lobar torsion

complicating bilateral lung transplantation. J Heart Lung Transplant 2003;22(1)102-6. 74. Gardner SC, Grunwald GK, Rumsfeld JS, Cleveland JC Kr. Dexiang G, Grover FL,

McDonald GO, Shroyer, L. Comparison of short-term mortality risk factors for valve replacement versus coronary artery bypass graft surgery. Ann Thorac Surg 2004;77:549-56.

75. Meldrum DR, Partrick DA, Cleveland JC Jr, Shenkar R, Medrum KK, Raiesdana A,

Ayala A, Brown JW, Harken AH. On-pump coronary artery bypass surgery activates human myocardial NF-kappaß and increases TNF-alpha in the heart. J Surg Res 2003;112(2)175-179.

76. Knaut AL, Cleveland JC Jr. Aortic Emergencies. Emergency Medicine Clinics of North America 2003;21(4):817-45.

77. Raeburn, C.D., Zimmerman, M.A., Banerjee, A., Cleveland, JC., Jr., Harken, A.H. Surgical applications of organ preconditioning. Minerva Chir 2004:59, 209-18.

78. Gardner SC, Grunwald GK, Rumsfeld JS, Cleveland JC Jr, Schooley LM, Gao D,

Grover FL, McDonald GO, Shroyer AL. Comparison of short-term mortality risk factors for valve replacement versus coronary artery bypass graft surgery. Ann Thorac Surg 2004;77:549-56.

79. Lindenfeld JA, Simon SF, Zamora MR, Cool CD, Wolfel, Lowes BD, Ireland N, Keller

K, Frisk R, Stepien L, Cleveland JC Jr, Zolty R. BOOP is common in cardiac transplant recipients switched from a calcineurin inhibitor to sirolimus. American Journal of Transplantation 2005, 5(6):1392-6.

80. Bridges CR, O’Brien SM, Cleveland JC, Savage EB, Gammie JS, Edwards FH,

Peterson ED, Grover FL. Association between indices of prosthesis internal orifice size and operative mortality after isolated aortic valve replacement. J Thorac Cardiovasc Surg 2007, 133(4):1012-21.

81. Lowes BD, Zolty R, Shakar SF, Brieke A, Gray N, Reed M, Calalb M, Minobe W,

Lindenfeld J, Wolfel EE, Geraci M, Bristow MR, Cleveland J Jr. Assist devices fail to

Cleveland 14

reverse patterns of fetal gene expression despite beta blockers. J Heart Lung Transplantation 2007;26:1170-6. .

82. Babu A, Meng X, Banerjee AM, Gamboni-Robertson F, Cleveland J, Damle S,

Fullerton DA, Weyant MJ. Secretory phospholipase A2 is required to produce histologic changes associated with gastroduodenal reflux in a murine model. J Thorac Cardiovasc Surg 2008 Jun;135(6):1220-7.

83. Meng X, Ao L, Song Y, Babu A, Yang M, Wang M, Weyant MJ, Dinarello CA, Cleveland J, Fullerton DA. Expression of functional toll-like receptors 2 and 4 in human aortic valve interstitial cells: potential roles in aortic valve inflammation and stenosis. Am J Physiol Cell Physiol 294:C29-C35, 2008.

84. Cleveland JC Jr, Grover FL, Fullerton DA, Campbell DN, Mitchell MB, Lindenfeld J, Wolfel EE, Lowes BD, Shakar SF, Brieke A, Cannon A, Robertson AD. Left ventricular assist device as bridge to transplantation does not adversely affect one-year heart transplantation survival. J Thorac Cardiovasc Surg 2008;136:774-7.

85. Argenziano M, Skipper E, Fudge T, Heimansohn D, Letsou G, Woo YJ, Kron I, Alexander J, Cleveland J, Kong B, Davidson M, Vassiliades, Krieger K, Sako E, Tibi P, Galloway A, Foster E, Feldman T, Glower D. Surgical revision after percutaneous mitral repair with the MitraClip® Device: Preservation of surgical options. Submitted, Ann Thorac Surg January 2008.

86. Brieke A, Cleveland J Jr., Lindenfeld J. Mechanical support in acute and chronic heart failure. Curr Cardiol Rep, 2008 May;10(3):168-75.

87. Babu AN, Meng X, Zou N, Yang X, Song Y, Cleveland JC, Weyant M, Banerjee A, Fullerton DA. Lipopolysaccharide stimulation of human aortic valve interstitial cells activates inflammation and osteogenesis. Ann Thorac Surg 2008 Jul;86(1):71-6.

88. Zou N, Ao L, Cleveland JC Jr., Yang X, Su X, Cai G, Banerjee A, Fullerton DA, Meng X. Critical role of extracellular heat shock cognate protein 70 in myocardial inflammatory response and cardiac dysfunction following global ischemia/reperfusion. Am J Physiol Heart Circ Physiol 2008 Jun;294(6)H2805-13.

89. Cleveland JC Jr. Invited Commentary: Navia DO, Vaccarion G et al. Total arterial off-pump coronary revascularization using bilateral internal thoracic arteries in triple vessel disease. Aug 2008 Ann Thorac Surg 86(2)530-1.

90. Reece TB, Mitchell JD, Zamora M, Fullerton DA, Cleveland JC, Pomerantz M, Lyu DM, Grover FL, Weyant MJ. Native lung volume reduction surgery relieves functional graft compression after single-lung transplantation for chronic obstructive pulmonary disease. J Thorac Cardiovasc Surg. 2008 Apr;135(4):931-7.

Cleveland 15

91. Yang X, Fullerton DA, Su X, Ao L, Cleveland JC Jr, Meng X. Pro-osteogenic phenotype of human aortic valve interstitial cells is associated with higher levels of Toll-like receptors 2 and 4 and enhanced expression of bone morphogenetic protein 2. JACC 2009 Feb 53(6):491-500.

92. Weitzel N, Puskas F, Cleveland J, Levi ME, Seres T. Left ventricular assist device outflow cannula obstruction by the rare environmental fungus myceliophthora thermophila. Anesth Analg. 2009 Apr;108(4):1105-6.

93. Cleveland JC Jr. Reply to the Editor re VAD publication. J Thorac Cardiovasc Surg 2009;137:787 The American Association for Thoracic Surgery.

94. Weitzel N, Puskas F, Cleveland J, Levi ME, Seres T. Left ventricular assist device outflow cannula obstruction by the rare environmental fungus Mycellophthora thermophilia. Anes Analg 2009 Jan;108(1):73-5.

95. Ao L, Zou N, Cleveland JC Jr., Fullerton DA, Meng X. Myocardial TLR4 is a determinant of neutrophil infiltration after global myocardial ischemia: Mediating IL-8 and MCP-1 expression induced by extracellular HSC70. Am J Physiol Heart Circ Physiol. Jul;297(1):H21-8 2009.

96. Zou N, Ao L, Cleveland J, Yang X, Su X, CAi GY, Banerjee A, Fullerton DA, Meng X. Role of extracellular heat shock cognate protein 70 in post-ischemic cardiac inflammatory response and dysfunction. J Mol Cell Cardiol 2008 (in review).

97. Song Y, Fullerton DA, Mauchley D, Su X, Ao L, Yang X, Cleveland JC, Meng X: Microfilament-facilitate TLR4-mediated ICAM-1 expression in human aortic valve interstitial cells. J Card Surg. 2009 Nov-Dec;24(6):677-81.

98. Ambardekar AV, Lowes B, Cleveland JC Jr, Brieke A. Overdrive pacing suppresses ectopy and minimizes left ventricular assist device suction events. Circ Heart Fail. 2009 Sept;2(5):516-7.

99. Rogers JH, Yeo KK, Carroll JD, Cleveland J, Reece TB, Gillinov AM, Rodriguez L, Whitlow P, Woo J. Late surgical mitral valve repair after percutaneous repair with the mitraClip® System. J Card Surg. 2009 Nov-Dec;24(6):677-81.

100. Yang X, Meng X, Su X, Mauchley DC, Ao L, Cleveland JC Jr, Fullerton DA. Bone morphogenic protein 2 induces Runx2 and osteopontin expression in human aortic valve interstitial cells: role of Smad1 and extracellular signal-regulated kinase 1/2. J Thorac Cardiovasc Surg. 2009 Oct;138(4):1008-15.

101. Ambardekar AV, Lowery CM, Allen LA, Cannon AP, Cleveland JC Jr., Lindenfeld J, Brieke A, Sauer WH. Effect of left ventricular assist device placement on preexisting implantable cardioverter-defibrillator leads. Journal of Heart and Lung Transplantation.

Cleveland 16

J Card Fail. 2010 Apr;16(4):327-31.

102. Ambardekar AV, Allen LA, Lindenfeld J, Lowery CM, Cannon AP, Cleveland JC Jr, Brieke A, Sauer WH. Implantable cardioverter-defibrillator shocks in patients with a left ventricular assist device. J Heart Lung Transplant. 2010 Jul;29(7):771-6.

103. Klein AJ, Hudson PA, Kim MS, Cleveland JC Jr, Messenger JC. Spontaneous left main coronary artery dissection and the role of intravascular ultrasonography. J Ultrasound Med. 2010 Jun;29(6):981-8.

104. Cleveland JC Jr. Frailty, aging, and cardiac surgery outcomes: the stopwatch tells the story. J Am Coll Cardiol. 2010 Nov 9;56(20):1677-8.

105. Cleveland JC Jr, Naftel DC , Reece TB, Murray M, Antaki J, Pagani FD, Kirklin JK. Survival after biventricular assist device implantation: An analysis of the Interagency Registry for Mechanically Assisted Circulatory Support database. J Heart Lung Transplant. 2011 Aug;30(8):862-9.

106. Li J, Jin C, Cleveland JC Jr, Ao L, Xu D, Fullerton DA, Ming X. Enhanced inflammatory responses to toll-like receptor 2/4 stimulation in type 1 diabetic coronary artery endothelial cells: the effect of insulin. Cardiovasc Diabetol. 2010 Dec 16;9:90.

107. Walker LA, Medway AM, Walker JS, Cleveland JC Jr, Buttrick PM. Tissue procurement strategies affect the protein biochemistry of human heart samples. J Muscle Res Cell Motil. 2011 Mar;31(5-6):309-14.

108. Smith PD, Puskas F, Fullerton DA, Meng X, Cho D, Cleveland JC Jr, Weyant MJ, Reece TB. Attenuation of spinal cord ischemia and reperfusion injury by erythropoietin. J Thorac Cardiovasc Surg. 2011 Jan;141(1):256-60.

109. LaPar DJ, Bhamidipati CM, Reece TB, Cleveland JC, Kron IL, Ailawadi G. Is off-pump coronary artery bypass grafting superior to conventional bypass in octogenarians? J Thorac Cardiovasc Surg. 2011 Jan;141(1):81-90.

110. Forman DE, Rich MW, Alexander KP, Zieman S, Maurer MS, Najjar SS, Cleveland JC Jr, Krumholz HM, Wenger NK. Cardiac care for older adults. Time for a new paradigm. J Am Coll Cardiol. 2011 May3;57(18):1801-10.

111. Lee JH, Meng X, Weyant MJ, Reece TB, Cleveland JC Jr, Fullerton DA. Stenotic aortic valves have dysfunctional mechanisms of anti-inflammation: implications for aortic stenosis. J Thorac Cardiovasc Surg. 2011 Feb;141(2):481-6.

112. Song Y, Fullerton DA, Mauchley D, Su X, Ao L, Yang X, Cleveland JC, Meng X. Microfilaments facilitate TLR4-mediated ICAM-1 expression in human aortic valve interstitial cells. J Surg Res. 2011 Mar;166(1):52-58.

Cleveland 17

113. Ambardekar AV, Walker JS, Walker LA, Cleveland JC Jr, Lowes BD, Buttrick PM. Incomplete recovery of myocytec function despite improvement of myocardial architecture with left ventricular assist device support. Circ Heart Fail. 2011 May 3.

114. Smith PD, Puskas F, Meng X, Cho D, Cleveland JC Jr, Weyant MJ, Watkins MT, Fullerton DA, Reece TB. Ischemic dose-response in the spinal cord: Both immediate and delayed paraplegia. J Surg Res. 2011 Apr 5.

115. Sadaria MR, Smith PD, Fullerton DA, Justison GA, Lee JH, Puskas F, Grover FL,

Cleveland JC Jr, Reece TB, Weyant MJ. Cytokine Expression Profile in Human Lungs Undergoing Normothermic Ex-Vivo Lung Perfusion. Ann Thorac Surg. 2011 June 24.

116. Ambardekar AV, Cannon AP, Cleveland JC Jr, Brieke A, Lindenfeld J. Driving with a

driveline: a survey of current practice patterns for allowing a patient supported with a left ventricular assist device to drive. J Heart Lung Transplant. 2011 June 29.

117. Weitzel NS, Edelstein SB, Cleveland JC Jr, Cornelissen CB. Drug-Eluting Stents in the

Perioperative Period: What Are the Key Aspects in Management? Semin Cariothorac Vasc Anesth. 2011 June 30.

Book Chapters:

1. Cleveland JC Jr, Harken AH. Coronary Artery Disease. In Surgical Secrets, 3rd Edition, Harken AH, Moore EE, eds., Hanley and Belfus, Inc., Phila, PA, 1996.

2. Cleveland JC Jr, Harken AH. Rational Strategies in the Management of the Surgical

Treatment of Ventricular Tachyarrhythmias. In Mastery of Cardiothoracic Surgery, 1st Edition, Kaiser LR, Kron IL, Spray TL, eds., Lippencott-Raven, Phila, PA 1998.

3. Cleveland JC Jr. Coronary Artery Disease. In Surgical Secrets, 4th Edition, Harken

AH, Moore EE, eds., Hanley and Belfus Inc., Phila, PA, 1999. 4. Pomerantz BJ, Cleveland JC Jr, Pomerantz M. The Schede and Modern

Thoracoplasty. In Operative Techniques in Cardiovascular and Thoracic Surgery. W. B. Saunders Company. Vol 5, No2, 2000:pp128-134.

5. Cleveland JC Jr., Grover FL. Prophylaxis against atrial fibrillation following open

heart surgery. In Advanced Therapy in Cardiac Surgery, 2e. Franco & Verrier eds., BC Decker, Hamilton, ON Canada, pending May 2002.

6. Cleveland JC Jr, Zamora MR, Grover FL. Complications Following Lung

Transplantation. In :Yang SC, Cameron DE, ed Current Therapy in Thoracic and Cardiovascular Surgery . Baltimore, MD: Mosby 2004.

7. Cleveland JC Jr. Coronary artery disease. In Surgical Secrets, 5th Edition, Harken,

Moore EE, eds Hanley and Belfus Inc., Phila PA, 2003.

Cleveland 18

8. Cleveland JC Jr. Ascending aortic dissection. In Treatment Strategies in Cardiovascular Disease. Teaching Publication for national hand held computer program. June 2003

9. Cleveland JC Jr. Thoracic aortic aneurysm. In Treatment Strategies in Cardiovascular

Disease. Teaching publication for national hand held computer program. June 2003. 10. Cleveland JC Jr., Mitchell JD, Grover FL. Databases and Clinical Outcomes: The

General Thoracic Surgery Database. In: Franco KL, Putman JB, editors. Advanced Therapy in Thoracic Surgery 2nd ed. Hamilton, Ontario: BC Decker, Inc.; May 2005.

11. Cleveland JC Jr, Francalancia NA. Geriatric Cardiac Surgery . In: New Frontiers in

Geriatric Research; An agenda for surgical and related medical specialties. eds. David H Soloman, Associate eds Joseph LoCicero III, Ronnie N Rosenthal. Submitted Aug 2006

12. Cleveland JC Jr, Shroyer LA, Grover FL. Cardiac Surgical Databases. In: Mastery of

Cardiothoracic Surgery, Second Edition, Kaiser LR, Kron IL and Spray TL eds. Philadelphia: Lippincott Williams and Wilkins. October 2006.

13. Cleveland JC Jr., Coronary Artery Disease. In: Abernathy’s Surgical Secrets, 6th Edition, Harken AH, Moore EE, eds. Mosby Elsevier. 2009

14. Cleveland JC Jr., Grover FL. Thrombosis and Thromboembolism of Prosthetic Cardiac Valves and Extracardiac Prostheses. In: Sabiston & Spencer Surgery of the Chest, 8th ed. Sellke FW, del Nido PJ, Swanson SJ, editors. Philadelphia, Pennsylvania: chpt 82, 2010.

15. Cleveland JC Jr., Preoperative Evaluation and Preparation in the Elderly Cardiac Surgery Patient. In: Cardiothoracic Surgery in the Elderly. Mark Katlic ed. Publisher: Springer Science + Business Media, Inc., 2010.

National Presentations

1. Diuretics in the Management of Acute Renal Failure. Presented at Horizons in Surgery, Breckenridge, Colorado, March 1994

2. Prevention of Sodium Accumulation Mediates Alpha-one Adrenergic Myocardial

Preconditioning. Presented at the Society of University Surgeons Thirty-Seventh Annual University Surgical Residents’ Conference, Denver , Colorado, February 1995

3. The Ross procedure (pulmonary autograft) International registry: The first 18 months result. Changing demographics and outcomes. Discussant at the AATS April 24, 1995, Boston, MA.

4. PKC Dependent Sodium-Hydrogen Exchange Mediates Alpha-one Adrenergic Stimulated Preservation of Ischemic PH. Presented at The American Heart Association 68th Scientific Session, Anaheim, California, November 1996

Cleveland 19

5. The Obligate Role of Protein Kinase C in Mediating Clinically Accessible Cardiac

Preconditioning. Presented at the 57th Annual Society of University Surgeons Meeting, Washington, D.C., February 1996

6. Stress Ulcers in 1996: Is Prophylaxis Still Warranted? Presented at Horizons in Surgery,

Breckenridge, Colorado, March 1996 7. Optimal Myocardial Protection: Cooling, Cardioplegia, and Conditioning. Presented at

The Rocky VI Frontiers in Valvular Surgery, Missoula, Montana, August 1996 8. Adenosine Preconditioning of Human Myocardium is Mediated Through KATP

Channel Activation. Presented at the 82nd Clinical Congress Surgical Forum, American College of Surgeons, San Francisco, California, October 1996

9. Ischemic Preconditioning of Human Myocardium: Protein Kinase C Mediates a

Permissive Role for Alpha-one Adrenoceptors. Presented at the American Heart Association 69th Annual Scientific Sessions, New Orleans, Louisiana, November 1996

10. Adenosine Receptor Stimulation Optimizes Preconditioning in Human Myocardium.

Presented at the Society of University Surgeons 39th Annual University Surgical Residents’ Conference, Tampa, Florida, February 1997

11. Is Surgery for Peptic Ulcer Disease Obsolete in 1997? Presented at Horizons in Surgery,

Breckenridge, Colorado, March 1997 12. Treatment of Acute Variceal Hemorrhage: TIPS vs. Endoscopic Therapy or Surgical

Shunts. Presented at Horizons in Surgery, Breckenridge, Colorado, March 1998

13. Off-Pump Coronary Artery Bypass Grafting Significantly Decreases Mortality and Morbidity. Presented at the 47th Annual Southern Thoracic Surgical Association, Marco Island, Florida, November 2000

14. Myocardial Hibernation. Presented at the Society of Critical Care medicine’s 31st

Critical Care Congress, San Diego, CA January 2002. 15. Preoperative Cardiopulmonary Work-up? What’s Really Needed? Presented at

Horizons in Surgery, Breckenridge, Colorado, March 2002. 16. On vs Off Pump Open Heart Surgery. Presented for Out Reach Program, Community

Hospital, Grand Junction, CO July 25, 2002.

17. Cardiac Assist Devices and Cardiac Transplantation. Visiting Professor University of South Carolina, Oct 15, 2002.

Cleveland 20

18. Ascending Aortic Dissection with Involvement of SMA/Renal Arteries. Presented for COBE Carbomedic Summit Seminar, March 5, 2004

19. On vs Off Pump CABG: Who and Why invited speaker for the American Heart

Association’s 72nd Annual Fall Symposium, UCLA, Los Angeles, CA, Oct 2, 2004. 20. Poster Presentation at the American Geriatrics Society Annual Meeting, Orlando, FL,

May 12, 2005 21. Invited speaker by the American College of Surgeons for the 91st Annual Clinical

Congress, Thoracic Transplantation, San Francisco, CA October 2005. 22. Invited Poster Presentation at the Hartford Interdisciplinary Scholars Conference.

Chicago, IL, July 11-13, 2005 23. 5th Vail Conference Cardiothoracic Transplantation 2005: An International Update.

Guest moderator, Vail, CO. March 16, 2005. 24. Invited speaker, Infected LVAD followed by Heart Transplantation. Sorin Group At the

Heart of Medical Technology Keystone, Colorado, March 17, 18, 2005 25. Invited speaker “Thoracic Transplantation” at the 91st Annual Clinical Concress,

October 18, 2005, San Francisco, CA 26. Invited speaker. Cardiogenic shock: The hidden surprises that provide challenges,

presented at COBE Carbomedic Summit Seminar, Keystone, CO March 10, 2006 27. Poster presentation American Geriatric Annual Meeting, Chicago, IL May 3-5, 2006 28. Invited discussant at the American College of Surgeons Forum on Fundamental Surgical

Problems. October 11, 2006 Chicago, Illinois. 29. Moderator at the Society of Thoracic Surgeons 43rd Annual meeting. Parallel Surgical

Forum II: Adult Cardiac II. San Diego, CA, January 29, 2007.

30. Invited panel discussant. American Society of Transplantation (AST) Winter Symposium. Phoenix, Arizona February 15-18, 2007

31. 6th Vail Cardiothoracic Transplantation An International Update (Co-Director)

Moderator March 19, 20, 2007 Vail, Colorado. 32. Invited Expert Panel Member for the “Developing Quality Indicators to Improve the

Care in Elderly Surgery Patients” National Institute on Aging panel discussion, April 26, 2007, Los Angeles, CA.

Cleveland 21

33. Guest moderator/poster presentation American Geriatric Society (Jahnigan) May 4, 2007, Seattle, WA

34. Invited panel member for the “Developing Quality Indicators to Improve the Care in Elderly Surgery Patients” NIA (National Institute on Aging) panel discussion April 26, 2007, Los Angeles, CA

35. Guest moderator/poster presentation, American Geriatric Society, May 4, 2007, Seattle, WA.

36. Pre-Transplant LVAD Does Not Adversely Affect One-Year Cardiac Transplant Survival. Presentation at WTSA 33rd Annual Meeting, Santa Ana, New Mexico 6/30/07

37. STS Program Planning Committee Meeting, August 17, 2007, Chicago, IL.

38. STS Legislative Advocacy Workshop, Washington DC, September 30, 2007. 39. Why would you implant a ventricular assist device? Invited speaker International

Transplant Nurses Society, October 4, 2007, Denver, CO. 40. Surgical Treatment of End-Stage Heart Disease. American College of Surgeons, Invited

Presenter/Moderator, Oct 8, 2007, New Orleans, LA 41. Poster presentation at AATS Heart Failure Course, Cleveland

Clinic, Cleveland, OH 10/29/2007.

42. Advisory Board Meeting, Essential Pharmaceuticals, Draft protocol for randomized trial for cardioplegic solution. Oct 2007, Philadelphia, PA.

43. Scholars Leadership Committee, American Geriatric Society, Fort Lauderdale, FL January 11, 2008

44. STS Leadership Workforce, invited moderator, Fort Lauderdale, Florida, January 25-30, 2008.

45. American Geriatric Society Council Retreat, Invited Speaker, Redondo Beach, CA, Feb 1-3, 2008

46. Program Committee, Western Thoracic Surgical Association, Seattle, Washington February 8-9, 2008.

47. Invited Consultant for Sildenafil, New York, NY February 14, 15, 2008.

48. Council Member/participant at the Section for Surgical and Related Medical Specialties Council Retreat; American Geriatric Society, Redondo Beach, CA. Feb 1-3, 2008

Cleveland 22

49. Council member/participant The AGS/John A. Hartford Foundation Project Council meeting Washington D.C. May 2, 3, 2008

50. Poster presentation “The Failure of Reverse Remodeling Following LVAD Placement: Discordance between Gene Expression and Ventricular Function”. The Heart Failure Society, Toronto, Canada, September 20, 2008.

51. Invited speaker “Mechanical circulatory support for the failing heart”. American College of Surgeons; San Francisco, CA October 10, 11, 2008.

52. Fixing a broken heart with VAD’s Invited lecturer for the Duke Thoracic Resident Symposium at the STS meeting San Francisco, January 24, 2009.

53. Invited moderator for the parallel sessions at the 45th Annual STS Meeting in San

Francisco, January 26, 2009.

54. Devices for the Treatment of Heart Failure, presented at the 38th Annual Society of Critical Care Congress, Nashville, TN, February 3, 2009.

55. Ventricular Assist Devices, presented at the 4th Annual Academic Surgical Congress, Sanibel Harbour Resort, Fort Meyers, Fl, Feb 5, 2009.

56. AMA Editorial Panel. Requested by the STS to sit as an expert regarding codes for VAD’s. Phoenix, AZ Feb 6, 2009.

57. Short and Long Term Approaches to Ventricular Assist Devices. Presentation at the Beaumont Hospital Beaver Creek Cardiovascular Conference. February 12, 2009.

58. Case presentation on LVADs. Sorin Mortality Conference, September 9-12, 2010, Washington DC.

59. AMA RUC panel. Testimony regarding VADs, Feb 2-6, 2011, Naples, Florida.

60. “Of Man and Machines – What to do when weaning from CPB fails”. Invited speaker at

Society of Cardiovascular Anesthesia Annual Meeting, May 3, 2011, Savannah, GA.

Guest Moderator National Conferences 1. Society of Thoracic Surgeons Workforce, Ft. Lauderdale, FL, January 25, 2008 2. Society of Thoracic Surgeons 45th Annual Meeting, San Francisco, CA January 24, 2009 3. Society of Critical Care Congress Annual Meeting. Nashville, TN February 3, 2009 4. American Transplant Congress, Boston, MA May 2009 5. Western Thoracic Surgical Association 35th Annual Meeting, June 2009 6. Moderator, 8th Vail Cardiothoracic Transplantation: An International Update, Vail CO, Jan 2011.

Cleveland 23

Local Presentations/Lectures/Mentor: 1. Non-Surgical Options in the Management of Chronic Pancreatitis. Presented at Surgical

Grand Rounds, University of Colorado, September 1992 2. Percutaneous Transluminal Coronary Angioplasty is Preferred for the Management of

Unstable Angina. Presented at Surgical Grand Rounds, University of Colorado, May 1993

3. Diuretics in the Management of Acute Renal Failure. Presented at Surgical Grand

Rounds, University of Colorado, October 1993 4. Optimal Management of Flail Chest Does Not Require Mechanical Ventilation.

Presented at Surgical Grand Rounds, University of Colorado, May 1994 5. Bacterial Translocation is Clinically Relevant. Presented at Surgical Grand Rounds,

University of Colorado, August 1994 6. Surgery for Morbid Obesity is Unnecessary and Ineffective in Maintaining Weight Loss.

Presented at Surgical Grand Rounds, University of Colorado, February 1995 7. Abdominal Aortic Rupture Following Blunt Trauma. Presented at the Colorado Chapter

of the American College of Surgeons, Breckenridge, Colorado, June 1995 8. Stress Ulcers in 1996: Is Prophylaxis Still Warranted? Presented at Surgical Grand

Rounds, University of Colorado, November 1995 9. Clinically Accessible Modulation of the Injury Response. Presented at the Colorado

Chapter of the American College of Surgeons, Breckenridge, Colorado, June 1996 10. Is Surgery for Peptic Ulcer Disease Obsolete in 1996? Presented at Surgical Grand

Rounds, University of Colorado, August 1996 11. Oral Hypoglycemic Agents Prevent Ischemic Preconditioning in Human Myocardium.

Presented at the Colorado Chapter of the American College of Surgeons, Breckenridge, Colorado, June 1997

12. Treatment of Acute Variceal Hemorrhage: TIPS vs. Endoscopic Therapy or Surgical

Shunts. Presented at Surgical Grand Rounds, University of Colorado, October 1997 13. The Epidemic of Blunt Carotid Arterial Injuries: Aggressive Screening Improves

Neurological Outcomes. Presented at the Colorado Chapter of the American College of Surgeons, Breckenridge, Colorado, June 1998

14. Minimally Invasive Coronary Artery Surgery: The Challenge of the Future. Presented at

Surgical Grand Rounds, University of Colorado, April 1999

Cleveland 24

15. Minimally Invasive Cardiac Surgery: Teaching an Old Dog New Tricks. Presented at Aspen Valley Hospital Grand Rounds, Aspen Colorado, February 2000

16. Update on Cardiac Surgery. Presented at Surgical Grand Rounds, University of

Colorado, April 2000 17. Transmyocardial Laser Revascularization: New Blood Vessels or Giant Placebo?

Presented at Surgical Grand Rounds, University of Colorado, August 2000 18. Thoracic Anatomy: Clinical Relevance for Medical Students. Presented to the 1st year

Medical Student Anatomy Lecture Series, University of Colorado, September 2000 19. Physical Exam and Correlates of the Thorax. Presented to1st year Medical Student

CSBI 5000 Human Anatomy Lecture Series, University of Colorado, Oct 16, 2001. 20. Left Ventricular Assist Devices. Presented at the Cardiac Catheterization Conference,

University of Colorado Health Sciences Center, Oct 30, 2001 21. Perfusion Techniques: Surgical Techniques On and Off Pump. Presented at the SICU

Nurses Luncheon at Denver Veterans Administration Medical Center, December 17, 2001.

22. Mentor to a Pre-Med student from Hastings College, NE for a credited, extra curricular,

six-week Internship. January/February 2002. 23. Mechanical Assist Devices. Presented at the Academic Lecture, Department of

Anesthesiology, UCHSC, February 6, 2002. 24. New technology assessment – surgical procedures. Implementing clinical knowledge

gained from evidence-based medicine”. Lecture for students in CLSC 6700 “Evidence Based Medicine” class. Presented March 28, 2002.

25. On and off pump coronary artery bypass and VA CSP #517. Presented to the VA SICU

nurses/heart orientation, April 15, 2002. 26. Bi-Ventricular Support System Training Seminar. Presented for regional cardiothoracic

surgeons and their support staff. Sponsored by Abiomed biventricular support system, April 24, 2002.

27. On vs off pump open heart surgery. Presented at the University of Colorado School of

Medicine Surgical Society, April 24, 2002. 28. Postgraduate Physiology Course Clinical Correlates. 29. Guest speaker for UCHSC Outreach Program. “On vs off pump coronary bypass”

presented at Community Hospital, Grand Junction, CO, July 26, 2002

Cleveland 25

30. Guest speaker for Rocky Mnt Thoracic & Cardiovascular Surgical Society “Techniques

and Outcomes for Ischemic MVR” September 5, 2002 31. “Minimally invasive CABG” Invited speaker for VA Medical Services Journal Club.

September 6, 2002

32. “Examination of Thorax” Lecture incoming freshmen UCHSC October 16, 2002.

33. “Postoperative Cardiac Surgical Management” Lecture VA ICU nurses, October 29, 2002

34. “VADS” Lecture for Cardiology Grand Rounds, UCHSC, January 21, 2003.

35. “New Surgical Strategies, on vs off pump heart surgery” Lecture Evidence Based Medicine Class, UCHSC, April 28, 2003.

36. “Cardiac Surgery” Lecture for Advanced Medical Surgical Nursing Concepts Course (a CME course for nurses) presented at UCHSC July 30, 2003

37. A meta-analysis of randomized controlled trials comparing coronary artery bypass graft with percutaneous transluminal coronary angioplasty. Faculty discussant for Cardiology Grand Rounds, UCHSC, May 19, 2003.

38. On vs Off Pump. Lecture for CME accredited Critical Care Course, UCHSC, August, 2003.

39. Who’s Coming for Surgery. Grand Rounds, University of CO Health Sciences Center,

January 2004.

40. Heart Valve Surgery. Invited speaker for Surgical Society, March 8, 2004.

41. Mitral Valve Surgery, when to repair, when to replace. Invited speaker Anesthesiology Grand Rounds, UCHSC, March 15, 2004

42. Aortic Valve Surgery: Is Repair Possible? Invited speaker Grand Rounds, UCHSC,

March 29, 2004 43. On Pump vs Off Pump CABG. Lecture, Evidence Based Medicine Class, UCHSC April

12, 2004.

44. Mentor/Preceptor in the Foundations of Doctoring Program. 1:1 mentoring premed student 3 Thurs afternoons each month from Sept 2003 to May 31, 2004.

45. Transplantation invited speaker for Anesthesia Grand Rounds, UCHSC 6/14/04.

Cleveland 26

46. Cardiothoracic Surgery Lecture Evidence Based Medicine Class CSP 517, UCHSC, 7/12/04.

47. Invited speaker Heart Institute, LVAD and Pediatric Application on Mechanical

Circulatory Support, Denver, CO November 29, 2004 48. Lecture on VAD’s to Critical Care Nurse Conference, University Hospital, November 8,

2004. 49. Invited speaker Cardiology J Club, Canyon Club Cherry Creek, Denver, CO January 26,

2005. 50. Invited speaker Fellows Symposium Sponsored by Guidant talk on VADS at the Teatro,

Hotel Denver, CO February 2005. 51. SICU Class CC332 Critical Care talk on Cardiac Surgical Procedures, March 7, 2005 52. Cardiothoracic Surgery Lecture Evidence Based Medicine Class CSP 517, UCHSC,

4/18/05. 53. Anesthesia Grand Rounds, University of Colorado Health Sciences Center, Heart

Transplantation an Update, January 9, 2006 54. Age related changes in Human Cytokine production during cardiac surgical procedures.

Presented Geriatric Research Conference, University of Colorado Health Sciences Center, Denver, CO February 23, 2006

55. Invited speaker Keystone Summit Seminar, Keystone, CO, March 9-11, 2006 56. Artificial heart and transplant capabilities. Invited interview with Jeanne Davant from

MD News. March 2006. 57. Invited speaker St. Joseph Hospital for Outreach Program. LVAD’s What you should

know. December 6, 2006. 58. Invited speaker Cardiology Grand Rounds, University of Colorado Health Sciences

Center, LVAD’s. December 12, 2006. 59. Invited speaker Geriatric Grand Rounds, University of Colorado Health Sciences Center,

Denver, CO. Old People and Heart Surgery., December 14, 2006. 60. Anesthesia Grand Rounds, University of Colorado Health Sciences Center, Denver, CO.

LVAD’s and Anesthesia. December 18, 2006

61. LVAD’s, University of Colorado Hospital Intensive Care Nurses, Denver, CO November 2007.

Cleveland 27

Cleveland 28

62. “Cardiothoracic Surgical Procedures 2008” VA Surgical Intensive Care Nurses, Denver,

CO February 2008.

63. “Mechanical Circulatory Support; Old dogs, new tricks”. Outreach Presentation, Brown Palace Hotel, Denver, CO Sept 11, 2008.

64. Mechanical Circulatory Support for End Stage Heart Failure: Old dogs and new tricks. Heart Center of the Rockies Cardiology 2008; Fort Collins, CO Oct 10, 2008.

65. URN site visit, Guest speaker on VAD’s and Transplants, University of Colorado Denver. Nov 3, 2008.

66. “Ventricular Assistance for the Failing Heart: Old Dogs and New Tricks”. Grand Rounds, UCD, Aurora, CO. November 17, 2008.

67. “Fixing a Broken Heart, Cardiac Transplantation 2009”. Invited guest speaker for Kaiser Grand Rounds, St. Joseph Hospital, Denver, CO June 5, 2009.

68. “New ventricular assist devices and their role in the management of heart failure” Anesthesiology Grand Rounds, University of Colorado Denver, June 7, 2010

69. Moderator/Presenter Cardiothoracic Fellows Educational Symposium. St. Julien Boulder Hotel, Boulder, CO September 17-18, 2010.