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© SPEX CertiPrep, Inc. 2011 Patricia Atkins Product Applications Specialist Chemistry & Cosmetics Analysis of Lipstick for Toxic Elements using ICP-MS
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Chemistry & Cosmetics - SPEX CertiPrep...© SPEX CertiPrep, Inc. 2011 Elements Measured Element Gas Mode Line Element Gas Mode Line Ag Air 107, 109 Ni He & Air 60 Al Air & He 27 Os

Apr 12, 2020

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Page 1: Chemistry & Cosmetics - SPEX CertiPrep...© SPEX CertiPrep, Inc. 2011 Elements Measured Element Gas Mode Line Element Gas Mode Line Ag Air 107, 109 Ni He & Air 60 Al Air & He 27 Os

© SPEX CertiPrep, Inc. 2011

Patricia Atkins

Product Applications Specialist

Chemistry & Cosmetics Analysis of Lipstick for Toxic Elements using ICP-MS

Page 2: Chemistry & Cosmetics - SPEX CertiPrep...© SPEX CertiPrep, Inc. 2011 Elements Measured Element Gas Mode Line Element Gas Mode Line Ag Air 107, 109 Ni He & Air 60 Al Air & He 27 Os

© SPEX CertiPrep, Inc. 2011

Housekeeping

Everyone in attendance today will receive a copy of the

presentation slides

The webinar is being recorded and will be posted to our

YouTube account about one week after the event

Questions will be answered at the end of the presentation

– Type any questions you may have into the question box

and we will answer them during the Q & A portion

Page 3: Chemistry & Cosmetics - SPEX CertiPrep...© SPEX CertiPrep, Inc. 2011 Elements Measured Element Gas Mode Line Element Gas Mode Line Ag Air 107, 109 Ni He & Air 60 Al Air & He 27 Os

© SPEX CertiPrep, Inc. 2011

History

Cosmetics have historically contained

toxic compounds

Egyptian cosmetics: Pb & Hg

– Kohl: burnt almonds, oxidized

copper, different-colored copper ores, lead, ash, arsenic

compounds & ochre

– Mesdemet: copper and lead ore

Greek & Romans

– White complexion = Pb

– Red colors = Cinnabar = Hg

– Brows = Stibium = Sb

Page 4: Chemistry & Cosmetics - SPEX CertiPrep...© SPEX CertiPrep, Inc. 2011 Elements Measured Element Gas Mode Line Element Gas Mode Line Ag Air 107, 109 Ni He & Air 60 Al Air & He 27 Os

© SPEX CertiPrep, Inc. 2011

History

Medieval & Renaissance

– White Pale Complexion

= Mask of Youth

• Used by men &

women

• Hydroxide, carbonate

& Pb oxide

– Elizabeth I

• Covered acne and pox

scars with heavy white

makeup

Page 5: Chemistry & Cosmetics - SPEX CertiPrep...© SPEX CertiPrep, Inc. 2011 Elements Measured Element Gas Mode Line Element Gas Mode Line Ag Air 107, 109 Ni He & Air 60 Al Air & He 27 Os

© SPEX CertiPrep, Inc. 2011

History

20th century

– Radium cosmetics & personal

products = ‘healthy glow’

• 1918

– Avg Salary = $1500

– Hourly wage= $0.30-$0.70

– Year rent $178

– $2 Compact = >$50 today

• 1930’s

– Radioactive materials

• 1950’s to today

– Spas with Radon

http://www.cosmeticsandskin.com

Page 6: Chemistry & Cosmetics - SPEX CertiPrep...© SPEX CertiPrep, Inc. 2011 Elements Measured Element Gas Mode Line Element Gas Mode Line Ag Air 107, 109 Ni He & Air 60 Al Air & He 27 Os

© SPEX CertiPrep, Inc. 2011

History

Modern products perception-

no toxic compounds

– Recalls on FDA

– Various problems from

physical to bacterial

contamination

Cosmetics used around the

globe

Generates hundreds of

billions of dollars of revenue

Page 7: Chemistry & Cosmetics - SPEX CertiPrep...© SPEX CertiPrep, Inc. 2011 Elements Measured Element Gas Mode Line Element Gas Mode Line Ag Air 107, 109 Ni He & Air 60 Al Air & He 27 Os

© SPEX CertiPrep, Inc. 2011

FDA regulates cosmetic industry

– No premarket approval for

finished cosmetics

– Regulates limits on additives &

colorants

Hepp et. Al = up to 3 ppm Pb

This study examines the lipstick

for a wide range of compounds

and re-examines the Pb level

Correlations examined between

colors, finish type and elemental

levels

Studies & Regulations

Page 8: Chemistry & Cosmetics - SPEX CertiPrep...© SPEX CertiPrep, Inc. 2011 Elements Measured Element Gas Mode Line Element Gas Mode Line Ag Air 107, 109 Ni He & Air 60 Al Air & He 27 Os

© SPEX CertiPrep, Inc. 2011

Chemistry of Lipstick

Base

– Waxes

– Oils

• Castor Oil

Preservatives

– Vitamins

– Antioxidants

Flavors

Finish components

– Esters – shine

– Micas - shine

Pigments & Colorants

Page 9: Chemistry & Cosmetics - SPEX CertiPrep...© SPEX CertiPrep, Inc. 2011 Elements Measured Element Gas Mode Line Element Gas Mode Line Ag Air 107, 109 Ni He & Air 60 Al Air & He 27 Os

© SPEX CertiPrep, Inc. 2011

Chemistry of Lipstick

Pigments & Colorants

– Organic Colorants

• Coal Tar colorants

– must undergo safety

testing

– only ingredients required

by FDA

• FD&C colors – safe for

internal & external use

• External D&C – external use

– Inorganic Colorants in Lipstick

• Iron Oxide Black

• Iron Oxide Red

• Iron Oxide Orange

• Iron Oxide Yellow

• Iron Oxide Brown

• Manganese Violet

Page 10: Chemistry & Cosmetics - SPEX CertiPrep...© SPEX CertiPrep, Inc. 2011 Elements Measured Element Gas Mode Line Element Gas Mode Line Ag Air 107, 109 Ni He & Air 60 Al Air & He 27 Os

© SPEX CertiPrep, Inc. 2011

Samples

48 Products from SPEX

CertiPrep Employees

Age: new to several years old

Price Range: $5 to $35 per

container

14 Brands

Products:

• Lip stains

• Lip gloss

• Lip balm

• Lipstick

Page 11: Chemistry & Cosmetics - SPEX CertiPrep...© SPEX CertiPrep, Inc. 2011 Elements Measured Element Gas Mode Line Element Gas Mode Line Ag Air 107, 109 Ni He & Air 60 Al Air & He 27 Os

© SPEX CertiPrep, Inc. 2011

Samples (cont.)

Beige/Tan (3)

Brown (7)

Light Pink (3)

Dark Pink (7)

Corals/Peaches (11) Berry/Wine (11)

White/Colorless (6)

48 Samples

Page 12: Chemistry & Cosmetics - SPEX CertiPrep...© SPEX CertiPrep, Inc. 2011 Elements Measured Element Gas Mode Line Element Gas Mode Line Ag Air 107, 109 Ni He & Air 60 Al Air & He 27 Os

© SPEX CertiPrep, Inc. 2011

Samples (cont.)

Metallic

Four types of finishes

Pearlescent Pearlescent

Matte Metallic Clear

Three physical state types

–Solid

–Semi-solid

–Liquid

Page 13: Chemistry & Cosmetics - SPEX CertiPrep...© SPEX CertiPrep, Inc. 2011 Elements Measured Element Gas Mode Line Element Gas Mode Line Ag Air 107, 109 Ni He & Air 60 Al Air & He 27 Os

© SPEX CertiPrep, Inc. 2011

Materials

SPEX CertiPrep Standards:

• CLMS-1: Multi Element Solution Standard 1

• CLMS-2: Multi Element Solution Standard 2

• CLMS-3: Multi Element Solution Standard 3

• CLMS-4: Multi Element Solution Standard 4

• Base Oil 20 Standard

Reagents:

• High Purity Nitric Acid

• High Purity Hydrofluoric Acid

• 4% Boric Acid Solution

Page 14: Chemistry & Cosmetics - SPEX CertiPrep...© SPEX CertiPrep, Inc. 2011 Elements Measured Element Gas Mode Line Element Gas Mode Line Ag Air 107, 109 Ni He & Air 60 Al Air & He 27 Os

© SPEX CertiPrep, Inc. 2011

Sample Preparation

Hepp, N. M., Mindak, W. R., and Cheng,

J., Journal of Cosmetic Science, Vol. 60,

No. 4, July/August, 2009.

Samples digested in CEM Mars 5

Microwave Unit

– XP-1500 Vessels

– two-step microwave digestion

procedure

Page 15: Chemistry & Cosmetics - SPEX CertiPrep...© SPEX CertiPrep, Inc. 2011 Elements Measured Element Gas Mode Line Element Gas Mode Line Ag Air 107, 109 Ni He & Air 60 Al Air & He 27 Os

© SPEX CertiPrep, Inc. 2011

Sample Preparation (cont.)

Step 1:

– 0.3 g of sample

– 7 mL high purity Nitric Acid

– 2 mL high purity HF

– Microwave Program:

• Ramp to 130°C over 15

minutes; hold 3 minutes

• Ramp to 200°C over 15

minutes; hold 30 minutes

• Allow to cool

Page 16: Chemistry & Cosmetics - SPEX CertiPrep...© SPEX CertiPrep, Inc. 2011 Elements Measured Element Gas Mode Line Element Gas Mode Line Ag Air 107, 109 Ni He & Air 60 Al Air & He 27 Os

© SPEX CertiPrep, Inc. 2011

Sample Preparation (cont.)

Step 2:

– 30 mL of 4% high purity

Boric Acid solution

– Microwave Program:

• Ramp to 170°C over

15 minutes; hold 10

minutes

Diluted to 50 mL DI H2O

Digestion blanks run prior

to sample digestion

Diluted 1000x prior to ICP-

MS analysis

Page 17: Chemistry & Cosmetics - SPEX CertiPrep...© SPEX CertiPrep, Inc. 2011 Elements Measured Element Gas Mode Line Element Gas Mode Line Ag Air 107, 109 Ni He & Air 60 Al Air & He 27 Os

© SPEX CertiPrep, Inc. 2011

Instrument Conditions

Instrumentation

– Macroelement analysis:

• PerkinElmer ICP-OES

Optima 7300

– Trace element analysis

• Agilent ICP-MS 7700

– Meinhard nebulizer

– Cyclonic spray chamber

– Analysis performed

• normal mode: air

• collision mode: Helium

Condition Setting

Power 1550 W

Plasma Gas 15 L/min

Aux Gas 0.3 L/min

Nebulizer 0.80 L/min

Sampling Rate 0.3 mL/min

Page 18: Chemistry & Cosmetics - SPEX CertiPrep...© SPEX CertiPrep, Inc. 2011 Elements Measured Element Gas Mode Line Element Gas Mode Line Ag Air 107, 109 Ni He & Air 60 Al Air & He 27 Os

© SPEX CertiPrep, Inc. 2011

Elements Measured

Element Gas Mode Line Element Gas Mode Line

Ag Air 107, 109 Ni He & Air 60

Al Air & He 27 Os Air 189

As Air & He 75 P Air 31

Au Air 197 Pb Air 206-208

Ba Air 135-137-138 Pd Air 105

Be Air 9 Pr Air 141

Ca He 44 Pt Air 195

Cd He 111-113 Rb Air 85

Ce Air 140 Re Air 187

Co Air & He 59 Rh Air 103

Cr Air & He 52&53 Ru Air 101

Cs Air 133 Sb Air 121, 123

Cu He 63 Sc He 45

Cu He 63 Se He 77

Fe He 56 Si He 30

Ga Air 71 Sm Air 147

Gd Air 156 Sn He & Air 117-120

Ge He 74 Sr He & Air 86 & 88

Hf Air 178-180 Ta Air 181

Hg Air 201 Tb Air 159

Ho Air 165 Te Air 125

In Air 115 Th Air 232

Ir Air 193 Ti Air 47

K He 39 Tl He 203, 205

La Air 139 Tm Air 169

Li Air 7 U Air 238

Lu Air 175 V He 51

Mg Air 24 W Air 182

Mn He 55 Y Air 89

Mo Air 95,97,98 Yb Air 172

Na Air 23 Zn He 66

Nd Air 146 Zr Air 90

Page 19: Chemistry & Cosmetics - SPEX CertiPrep...© SPEX CertiPrep, Inc. 2011 Elements Measured Element Gas Mode Line Element Gas Mode Line Ag Air 107, 109 Ni He & Air 60 Al Air & He 27 Os

© SPEX CertiPrep, Inc. 2011

Results: Trace Elements

Precious metals and rare elements found in small

amounts

– Ag = 0.21 ppm

– Au = 0.22 ppm

– Pt = 0.74 ppm

Correlations between colors

– Ag = Peach color; exclusively one brand

– Au = Browns and Berries; multiple brands, one

predominant

– Pt = Whites and Browns but not in Berries;

predominate in one brand

– Pd = Berries & Dark Pinks

Correlation between finishes

– Au = Metallic not Pearls

– Ag = Pearls not Metallic

– Ir = Pearls not Metallic

Element Avg (ppm) Max (ppm)

Ag 0.04 0.21

Au 0.02 0.22

Cu 1.47 7.20

Ga 2.01 4.28

Gd 0.03 0.15

Ge 0.25 1.37

Hf 0.15 1.13

In 0.07 0.95

Ir 0.47 3.62

La 0.40 1.29

Nd 0.07 0.68

Pd 0.02 0.10

Pr 0.01 0.10

Pt 0.03 0.74

Re 0.00 0.04

Rh 0.03 0.21

Se 0.13 0.52

Sm 0.03 0.13

Ta 0.86 1.90

Th 0.06 0.27

W 3.04 8.63

Y 0.07 0.26

Yb 0.01 0.04

Page 20: Chemistry & Cosmetics - SPEX CertiPrep...© SPEX CertiPrep, Inc. 2011 Elements Measured Element Gas Mode Line Element Gas Mode Line Ag Air 107, 109 Ni He & Air 60 Al Air & He 27 Os

© SPEX CertiPrep, Inc. 2011

Results: Macroelements

Very high Al, Ca, K levels

– Concern over Al?

Expect large amounts of Fe, K,

Mg, Si, Ti

Element Avg (ppm) Max (ppm)

Al 38283.69 360,790.97

Ba 2734.56 26,494.60

Ca 28248.93 345,753.07

Fe 8262.90 63,177.23

K 11917.92 128,129.69

Li 19.51 144.52

Lu 107.65 335.41

Mg 610.38 5,566.33

Mn 20.52 90.38

Na 380.01 2,962.92

P 13.36 97.81

Rb 22.94 82.00

Sc 3.90 101.37

Si 13387.93 47,661.39

Sn 21.77 359.28

Sr 30.28 255.13

Ti 14664.03 38,477.15

Zn 40.13 1,084.94

Zr 8.10 39.37

Page 21: Chemistry & Cosmetics - SPEX CertiPrep...© SPEX CertiPrep, Inc. 2011 Elements Measured Element Gas Mode Line Element Gas Mode Line Ag Air 107, 109 Ni He & Air 60 Al Air & He 27 Os

© SPEX CertiPrep, Inc. 2011

Results: Macroelements (cont.)

0

20,000

40,000

60,000

80,000

100,000

120,000

140,000

160,000

Al Ca Fe K Si Ti

Co

nce

ntr

ati

on

(p

pm

)

Macroelement

White

Lt Pink

Dk Pink

Coral

Berry

Tan

Brown

Page 22: Chemistry & Cosmetics - SPEX CertiPrep...© SPEX CertiPrep, Inc. 2011 Elements Measured Element Gas Mode Line Element Gas Mode Line Ag Air 107, 109 Ni He & Air 60 Al Air & He 27 Os

© SPEX CertiPrep, Inc. 2011

Results: Macroelements (cont.)

0

200

400

600

800

1,000

1,200

1,400

1,600

1,800

Mg Mn Zn Zr

Co

nce

ntr

ati

on

(p

pm

)

Macroelement

White

Lt Pink

Dk Pink

Coral

Berry

Tan

Brown

Page 23: Chemistry & Cosmetics - SPEX CertiPrep...© SPEX CertiPrep, Inc. 2011 Elements Measured Element Gas Mode Line Element Gas Mode Line Ag Air 107, 109 Ni He & Air 60 Al Air & He 27 Os

© SPEX CertiPrep, Inc. 2011

Results: Macroelements (cont.)

Correlation with Color

– Darker colors, higher concentrations

• Cu

• K

• Mn

• Se

• Low Zr

• Low Si

• Al

• Ca

• Si

• Zn

• Cu • K

• Mn

• Se

• Al

• Ca

• Si

• Zn

• P

• Zr • W

• Low Ca

Page 24: Chemistry & Cosmetics - SPEX CertiPrep...© SPEX CertiPrep, Inc. 2011 Elements Measured Element Gas Mode Line Element Gas Mode Line Ag Air 107, 109 Ni He & Air 60 Al Air & He 27 Os

© SPEX CertiPrep, Inc. 2011

Results: Macroelements (cont.)

Matte

Metallic

Pearlescent

Correlation with Finish Type

Page 25: Chemistry & Cosmetics - SPEX CertiPrep...© SPEX CertiPrep, Inc. 2011 Elements Measured Element Gas Mode Line Element Gas Mode Line Ag Air 107, 109 Ni He & Air 60 Al Air & He 27 Os

© SPEX CertiPrep, Inc. 2011

Results: Toxic Elements

Pb cited up to 3 ppm (Hepp et al)

– Our max = 2.4 ppm

– Avg = 1 ppm

Highest potentially toxic or

hazardous elements

– Cr = 31 ppm

– Ni = 23 ppm

– V = 51 ppm

– Sb = 10 ppm

Low ppb levels found of Cd, Hg &

U

Element Avg Min Max

As 0.30 0 0.69

Be 0.49 ND 1.23

Ce 0.24 ND 3.37

Co 0.44 ND 4.30

Cr 2.44 0 31.45

Cs 1.68 ND 4.76

Mo 0.27 0 4.12

Ni 2.88 0 23.36

Pb 0.96 ND 2.39

Sb 0.33 ND 9.58

Tl 0.08 ND 0.23

V 4.68 ND 50.72

Page 26: Chemistry & Cosmetics - SPEX CertiPrep...© SPEX CertiPrep, Inc. 2011 Elements Measured Element Gas Mode Line Element Gas Mode Line Ag Air 107, 109 Ni He & Air 60 Al Air & He 27 Os

© SPEX CertiPrep, Inc. 2011

Results: Toxic Elements (< 1ppm)

0.00

0.10

0.20

0.30

0.40

0.50

0.60

0.70

0.80

0.90

As Be Ce Mo Tl

Co

nce

ntr

ati

on

(p

pm

)

Trace Element

White

Lt Pink

Dk Pink

Coral

Berry

Tan

Brown

Page 27: Chemistry & Cosmetics - SPEX CertiPrep...© SPEX CertiPrep, Inc. 2011 Elements Measured Element Gas Mode Line Element Gas Mode Line Ag Air 107, 109 Ni He & Air 60 Al Air & He 27 Os

© SPEX CertiPrep, Inc. 2011

Results: Toxic Elements (<10 ppm)

0.00

1.00

2.00

3.00

4.00

5.00

6.00

7.00

8.00

Co Cr Cs Ni Pb Sb W

Co

nce

ntr

ati

on

(p

pm

)

Trace Element

White

Lt Pink

Dk Pink

Coral

Berry

Tan

Brown

Page 28: Chemistry & Cosmetics - SPEX CertiPrep...© SPEX CertiPrep, Inc. 2011 Elements Measured Element Gas Mode Line Element Gas Mode Line Ag Air 107, 109 Ni He & Air 60 Al Air & He 27 Os

© SPEX CertiPrep, Inc. 2011

Results: Toxic Elements (<100 ppm)

0.00

10.00

20.00

30.00

40.00

50.00

60.00

70.00

80.00

90.00

100.00

Sn Sr V

Co

nce

ntr

atio

n (

pp

m)

Trace Element

White

Lt Pink

Dk Pink

Coral

Berry

Tan

Brown

Page 29: Chemistry & Cosmetics - SPEX CertiPrep...© SPEX CertiPrep, Inc. 2011 Elements Measured Element Gas Mode Line Element Gas Mode Line Ag Air 107, 109 Ni He & Air 60 Al Air & He 27 Os

© SPEX CertiPrep, Inc. 2011

Results: Toxic Elements (cont.)

• V

• As • V

• Sr

• As

• Pb

• Tl

• Pb

• Sr

• Pb

• Sr

Correlations with Color Higher concentration = Darker colors

Page 30: Chemistry & Cosmetics - SPEX CertiPrep...© SPEX CertiPrep, Inc. 2011 Elements Measured Element Gas Mode Line Element Gas Mode Line Ag Air 107, 109 Ni He & Air 60 Al Air & He 27 Os

© SPEX CertiPrep, Inc. 2011

Results: Toxic Elements (cont.)

Pearlescent

Matte

Metallic

Correlation with Finish Type

Page 31: Chemistry & Cosmetics - SPEX CertiPrep...© SPEX CertiPrep, Inc. 2011 Elements Measured Element Gas Mode Line Element Gas Mode Line Ag Air 107, 109 Ni He & Air 60 Al Air & He 27 Os

© SPEX CertiPrep, Inc. 2011

What does this mean?

Exposure & Human Limits

The EPA RfD – is the oral reference dosage

defined as: ‘…an estimate … of a daily exposure

to the human population (including sensitive

subgroups) that is likely to be without an

appreciable risk of deleterious effects during a

lifetime…expressed in units of milligrams per

kilogram of bodyweight per day (mg/kg/day).’

WHO - The TDI is an estimate of

the amount of a substance in food

or drinking-water, expressed on a

body weight basis (mg/kg or μg/kg

of body weight), that can be

ingested daily over a lifetime

without appreciable health risk.

Page 32: Chemistry & Cosmetics - SPEX CertiPrep...© SPEX CertiPrep, Inc. 2011 Elements Measured Element Gas Mode Line Element Gas Mode Line Ag Air 107, 109 Ni He & Air 60 Al Air & He 27 Os

© SPEX CertiPrep, Inc. 2011

Exposure

Element

Max

Concentration in

Lipstick (ug/g)

ug in 0.10 g

lipstick

EPA or WHO RfD

(ug/kg/day)

Calculated Rfd for

163-lb (74 kg)

Adult Female

(ug/kg)

Amount of lipstick

needed to exceed

RfD (g)

As 0.88 0.0088 4 296 334.54

Ba 26494.60 264.9460 200 14800 0.56

Be 1.17 0.0117 2 148 126.28

Cd 0.04 0.0004 1 74 1684.66

Cr 31.45 0.3145 3 222 7.06

Hg 0.08 0.0008 0.1 7.4 87.49

Ni 23.36 0.2336 20 1480 63.35

Pb 2.39 0.0239 3.6 266.4 111.39

Sb 9.58 0.0958 0.4 29.6 3.09

Sr 109.24 1.0924 600 44400 406.43

Tl 0.21 0.0021 0.1 7.4 34.66

U 0.05 0.0005 3 222 4639.80

V 36.43 0.3643 9 666 18.28

Page 33: Chemistry & Cosmetics - SPEX CertiPrep...© SPEX CertiPrep, Inc. 2011 Elements Measured Element Gas Mode Line Element Gas Mode Line Ag Air 107, 109 Ni He & Air 60 Al Air & He 27 Os

© SPEX CertiPrep, Inc. 2011

Exposure

Element

Amount of tubes of

lipstick consumed in

one day to exceed RfD

Ba 0.25

Sb 1

Tl 11

Hg 30

Pb 37

As 111

Cd 560

Page 34: Chemistry & Cosmetics - SPEX CertiPrep...© SPEX CertiPrep, Inc. 2011 Elements Measured Element Gas Mode Line Element Gas Mode Line Ag Air 107, 109 Ni He & Air 60 Al Air & He 27 Os

© SPEX CertiPrep, Inc. 2011

Conclusions

Many elements found

present in lipstick

Toxic elements

–Pb found up to 2 ppm

–Very Low Hg, Cd

found

Very High amount of Al

Page 35: Chemistry & Cosmetics - SPEX CertiPrep...© SPEX CertiPrep, Inc. 2011 Elements Measured Element Gas Mode Line Element Gas Mode Line Ag Air 107, 109 Ni He & Air 60 Al Air & He 27 Os

© SPEX CertiPrep, Inc. 2011

Conclusions

The highest concentrations of

elements in darker colors

Light colors, glosses or balms

have lowest concentrations

The exposure rate to the toxic

elements is very small

Large amounts of lipstick would

have to be consumed to reach

RfD levels

Page 36: Chemistry & Cosmetics - SPEX CertiPrep...© SPEX CertiPrep, Inc. 2011 Elements Measured Element Gas Mode Line Element Gas Mode Line Ag Air 107, 109 Ni He & Air 60 Al Air & He 27 Os

© SPEX CertiPrep, Inc. 2011

Acknowledgements

Thanks to all the employees of SPEX CertiPrep &

SamplePrep

Huifang Lang, Chemist, SPEX CertiPrep

Lazlo Ernyei, ICP Chemist, SPEX CertiPrep

Bill Driscoll, ICP-MS Chemist, SPEX CertiPrep

Vanaja Sivakumar, VP Inorganics, SPEX CertiPrep

Method by Hepp, N. M., Mindak, W. R., and Cheng, J., Journal of

Cosmetic Science, Vol. 60, No. 4, July/August, 2009.

Page 37: Chemistry & Cosmetics - SPEX CertiPrep...© SPEX CertiPrep, Inc. 2011 Elements Measured Element Gas Mode Line Element Gas Mode Line Ag Air 107, 109 Ni He & Air 60 Al Air & He 27 Os

© SPEX CertiPrep, Inc. 2011

Questions?

Page 38: Chemistry & Cosmetics - SPEX CertiPrep...© SPEX CertiPrep, Inc. 2011 Elements Measured Element Gas Mode Line Element Gas Mode Line Ag Air 107, 109 Ni He & Air 60 Al Air & He 27 Os

© SPEX CertiPrep, Inc. 2011

New in 2011

Visit www.spexcertiprep.com for more information!

2011-2012 Catalog – Now

available on CD!

New Consumer Safety

standards kit for USP 232 (Part# USP-TXM1)

Page 39: Chemistry & Cosmetics - SPEX CertiPrep...© SPEX CertiPrep, Inc. 2011 Elements Measured Element Gas Mode Line Element Gas Mode Line Ag Air 107, 109 Ni He & Air 60 Al Air & He 27 Os

© SPEX CertiPrep, Inc. 2011

Connect with us!

Come visit us on your favorite social networking site!

facebook.com/spexcertiprep

youtube.com/spexcertiprep

@spexcertiprep

Page 40: Chemistry & Cosmetics - SPEX CertiPrep...© SPEX CertiPrep, Inc. 2011 Elements Measured Element Gas Mode Line Element Gas Mode Line Ag Air 107, 109 Ni He & Air 60 Al Air & He 27 Os

© SPEX CertiPrep, Inc. 2011

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Page 41: Chemistry & Cosmetics - SPEX CertiPrep...© SPEX CertiPrep, Inc. 2011 Elements Measured Element Gas Mode Line Element Gas Mode Line Ag Air 107, 109 Ni He & Air 60 Al Air & He 27 Os

© SPEX CertiPrep, Inc. 2011

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