1 1 NIH Career Development NIH Career Development Programs (“K” Awards) Programs (“K” Awards) ( ( http://grants1.nih.gov/training/careerdevelopmentawards.htm http://grants1.nih.gov/training/careerdevelopmentawards.htm) ) James Hyde, Ph.D. James Hyde, Ph.D. Division of Diabetes, Endocrinology Division of Diabetes, Endocrinology & Metabolic Diseases & Metabolic Diseases NIDDK/NIH NIDDK/NIH Email:Email: [email protected][email protected]Pam Gilden Pam Gilden Office of Policy for Extramural Office of Policy for Extramural Research Administration (OPERA) Research Administration (OPERA) Office of Extramural Research, NIH Office of Extramural Research, NIH Email: Email: [email protected][email protected]
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Pam GildenPam GildenOffice of Policy for ExtramuralOffice of Policy for Extramural
Research Administration (OPERA)Research Administration (OPERA)Office of Extramural Research, NIHOffice of Extramural Research, NIHEmail:Email: [email protected]@nih.gov
To help ensure that a diverse pool of To help ensure that a diverse pool of highly trained scientists are available inhighly trained scientists are available inadequate numbers and in theadequate numbers and in theappropriate research areas to addressappropriate research areas to address
the Nation’s biomedical, behavioral,the Nation’s biomedical, behavioral,and clinical research needs.and clinical research needs.
Career Development ProgramsCareer Development Programs
• Become a well-informed applicantBecome a well-informed applicant
• Find out about NIH Institute and Center Find out about NIH Institute and Center
(IC) missions and programs(IC) missions and programs www.nih.govwww.nih.gov
• Find out about IC specific utilization of theFind out about IC specific utilization of thewide variety of K activity codeswide variety of K activity codes
Research Project GrantResearch Project Grant(R01)(R01)
Independent Scientist Award (K02)Independent Scientist Award (K02)
Senior Scientist Award (K05Senior Scientist Award (K05))
Approx. Stage of ResearchTraining and Development Activity Codes
GRADUATE/GRADUATE/
MEDICALMEDICAL
STUDENTSTUDENT
POSTPOST
DOCTORALDOCTORAL
EARLYEARLY
MIDDLEMIDDLE
SENIORSENIOR
CAREER
CAREER
Predoctoral Institutional Training Grant (T32)Predoctoral Institutional Training Grant (T32)
NIH Pathway to Independence (PI) Award (K99/R00)NIH Pathway to Independence (PI) Award (K99/R00)Mentored Research Scientist Development AwardMentored Research Scientist Development Award(K01)(K01)Mentored Clinical Scientist Development Award (K08)Mentored Clinical Scientist Development Award (K08)Mentored Patient-Oriented RCDA (K23)Mentored Patient-Oriented RCDA (K23)Mentored Quantitative RCDA (K25)Mentored Quantitative RCDA (K25)
Midcareer Investigator Award inMidcareer Investigator Award in
Patient-Oriented Research (K24)Patient-Oriented Research (K24)Exploratory/DevelopmentExploratory/Development
Grant (R21)Grant (R21)
NIH Training and Career Development TimetableNIH Training and Career Development Timetable
* Count includes noncompeting continuations. Competing applications for K04, K11, K14, K15, K16, K17, K20 and K21 werediscontinued in FY 1995. K99, KL1 and KL2 are new activities as of FY 2007.
• Duration:Duration: three, four, or five yearsthree, four, or five years – Extensions in time – award terms remain inExtensions in time – award terms remain in
effect (i.e. minimum effort, no salary from other effect (i.e. minimum effort, no salary from other federal funding source)federal funding source)
• Entry level awards require a mentor, multipleEntry level awards require a mentor, multiplementors are OKmentors are OK
• Mentored Ks encouraged to apply for Mentored Ks encouraged to apply for independent support during Kindependent support during K
• Level of EffortLevel of Effort:: – Mentored awards require full-time effort (definedMentored awards require full-time effort (defined
as at least 75 percent on research and the rest onas at least 75 percent on research and the rest on
other career development activities)other career development activities) – Policy (Policy (Issued 8/2004Issued 8/2004)): For K eligibility purposes,: For K eligibility purposes,individual must have a full-time appointment atindividual must have a full-time appointment at
applicant organization; and the minimum effortapplicant organization; and the minimum effortrequirement must be covered by thatrequirement must be covered by thatappointment. Guide Notice: OD-04-056:appointment. Guide Notice: OD-04-056:http://grants.nih.gov/grants/guide/notice-files/NOT-OD-04-056.htmlhttp://grants.nih.gov/grants/guide/notice-files/NOT-OD-04-056.html
Common Features: Effort (cont’d)Common Features: Effort (cont’d)
• Policy (Policy (Issued 11/2003Issued 11/2003)):: Mentored Mentored awards inawards infinal 2 years may now reduce effort on K if final 2 years may now reduce effort on K if replaced by effort as a PD/PI or subproject PD/PIreplaced by effort as a PD/PI or subproject PD/PIprovided they remain in mentored situation.provided they remain in mentored situation.
– Effective with applications submitted since 2/1/04Effective with applications submitted since 2/1/04 – See NIH GUIDE Notice:See NIH GUIDE Notice:
Some costs vary widely across NIH ICs. ReviewSome costs vary widely across NIH ICs. Reviewspecific Program Announcements carefully.specific Program Announcements carefully.
• Salary/fringe benefitsSalary /fringe benefits:: – Salaries capped betweenSalaries capped between $75,000$75,000 and legislativelyand legislatively
mandated cap (currentlymandated cap (currently $191,300$191,300)) – Fringe benefits are over & above any salary capFringe benefits are over & above any salary cap – Salary supplementation OK, but must be from non-Salary supplementation OK, but must be from non-
Federal sources & not require extra duties that wouldFederal sources & not require extra duties that wouldinterfere with K activitiesinterfere with K activities
• Research/development costsResearch/development costs:: – GenerallyGenerally $25,000 to $50,000$25,000 to $50,000 – Commonly used for: supplies, equipment, technicalCommonly used for: supplies, equipment, technical
personnel, travel to research meetings or training,personnel, travel to research meetings or training,tuition/fees, computational servicestuition/fees, computational services
• Other incomeOther income:: – Fees resulting from research activities required byFees resulting from research activities required by
the K award may not be retained by the recipientthe K award may not be retained by the recipient
– Royalties and fees may be retained if incidental,Royalties and fees may be retained if incidental,
not required by research & training activities of thenot required by research & training activities of theK award, and consistent with grantee institution’sK award, and consistent with grantee institution’spolicies. Examples: scholarly writing, service onpolicies. Examples: scholarly writing, service onadvisory groups, lecturer/speaker fees, feesadvisory groups, lecturer/speaker fees, feesresulting from clinical practice, professionalresulting from clinical practice, professional
consulting, or other comparable activitiesconsulting, or other comparable activities• Change of Institution or Mentor Change of Institution or Mentor ::
Requires prior approval in writing of the NIHRequires prior approval in writing of the NIHawarding component; contact NIH staff ASAP!awarding component; contact NIH staff ASAP!
Transition to E-SubmissionTransition to E-Submission
• Transition for “K” awards to the SF-424Transition for “K” awards to the SF-424(R&R) and electronic submission is on(R&R) and electronic submission is onHOLDHOLD
• Timeline and other E-SubmissionTimeline and other E-Submission
information found at:information found at:http://era.nih.gov/ElectronicReceipt/http://era.nih.gov/ElectronicReceipt/
s K01:K01: Mentored Research ScientistMentored Research ScientistDevelopment AwardDevelopment Award
s K08:K08: Mentored Clinical Scientist DevelopmentMentored Clinical Scientist DevelopmentAwardAward
s
K22:K22: Research Career Award for Transition toResearch Career Award for Transition toIndependenceIndependences K23:K23: Mentored Patient-Oriented ResearchMentored Patient-Oriented Research
Development AwardDevelopment Awards K25:K25: Mentored Quantitative ResearchMentored Quantitative Research
Development AwardDevelopment Awards K99/R00:K99/R00: NIH Pathway to Independence (PI)NIH Pathway to Independence (PI)AwardAward
s K12:K12: Institutional Mentored Research ScientistInstitutional Mentored Research ScientistDevelopment ProgramDevelopment Program
Mentored K Awards: Which One?Mentored K Awards: Which One?
K08: Option for Hlth. Prof. DegreeK08: Option for Hlth. Prof. Degree
• Supervised research experience for Supervised research experience for individuals with health professionalindividuals with health professionaldegree who are committed to a career degree who are committed to a career
in laboratory or field-based researchin laboratory or field-based research• Phased award periodPhased award period
• didactic experiencedidactic experience
• ““hands-on” research experiencehands-on” research experience• Can support non-patient-orientedCan support non-patient-oriented
K22: Option for Res./Clin. DegreeK22: Option for Res./Clin. Degree
• Each participating IC has specific eligibility criteria andEach participating IC has specific eligibility criteria andaward provisionsaward provisions
• Assists transition to independenceAssists transition to independence
• Applications may haveApplications may have nono applicant institutionapplicant institution
• NIH issues a provisional award letter NIH issues a provisional award letter
• Activated after identifying a suitable position at a researchActivated after identifying a suitable position at a researchinstitutioninstitution
• Might include continuing postdoctoral segmentMight include continuing postdoctoral segment
• Several include intramural phase & extramural phaseSeveral include intramural phase & extramural phase
• Eligibility may be restrictedEligibility may be restricted• ICs using this mechanism: NIAID, NIAMS, NCI, NICHD,ICs using this mechanism: NIAID, NIAMS, NCI, NICHD,
NIDA, NIDCR, NIEHS, NHGRI, NHLBI, NINR, NLM (NIDA, NIDCR, NIEHS, NHGRI, NHLBI, NINR, NLM (many many are phasing these out & using K99/R00 instead are phasing these out & using K99/R00 instead ))
K23: Option for Patient ResearchK23: Option for Patient Research
• 3-5 yrs supervised study & research for clinically3-5 yrs supervised study & research for clinicallytrained professionals with a commitment to focustrained professionals with a commitment to focusresearch on patient-oriented research (POR)research on patient-oriented research (POR)
• POR is defined as research conducted with humanPOR is defined as research conducted with humansubjects (or material of human origin such as tissues,subjects (or material of human origin such as tissues,specimens) for which PD/PI directly interacts withspecimens) for which PD/PI directly interacts withhuman subjectshuman subjects
• Requires clinical doctorate or equivalentRequires clinical doctorate or equivalent
• Must have completed clinical training, (includingMust have completed clinical training, (including
specialty/sub-specialty if applicable) prior tospecialty/sub-specialty if applicable) prior to awardaward• MayMay submitsubmit application prior to completion of clinicalapplication prior to completion of clinical
K99/R00: Option for TransitionK99/R00: Option for Transition
• Provides up to 5 years of support in two phasesProvides up to 5 years of support in two phases• K99: Provides an intensive, mentored research experienceK99: Provides an intensive, mentored research experience
for up to 2 yearsfor up to 2 years• R00: Independent scientist phase; transition to researchR00: Independent scientist phase; transition to research
independence as junior faculty (up to 3 years of support)independence as junior faculty (up to 3 years of support)
• Applicants: no more than 5 years of postdoctoral researchApplicants: no more than 5 years of postdoctoral researchtraining at the time of initial application or resubmission(s)training at the time of initial application or resubmission(s)• U.S. citizensU.S. citizens and non-U.S. citizensand non-U.S. citizens may applymay apply• Domestic institutions only (both phases)Domestic institutions only (both phases)• Transition to R00 phase requires offer and acceptance of Transition to R00 phase requires offer and acceptance of
tenure-track, full-time assistant professor position (or tenure-track, full-time assistant professor position (or equivalent)equivalent)
New Investigators Program – Pathway to Independence Award:New Investigators Program – Pathway to Independence Award: http://grants.nih.gov/grants/new_investigators/pathway_independence.htmhttp://grants.nih.gov/grants/new_investigators/pathway_independence.htm
K12: Options for InstitutionsK12: Options for Institutions
• K12: Institutional Mentored Research ScientistK12: Institutional Mentored Research ScientistDevelopment ProgramDevelopment Program – Enhance research career development for Enhance research career development for
individuals,individuals, selected by the institution,selected by the institution, who arewho are
training for careers in specified research areastraining for careers in specified research areas
– Provides institutions with a greater capacity for Provides institutions with a greater capacity for mentoring junior investigatorsmentoring junior investigators
– Not transferable to another institutionNot transferable to another institution
– Usually solicited by a Funding OpportunityUsually solicited by a Funding OpportunityAnnouncement (FOA)Announcement (FOA)
Mentored K Awards: ReviewMentored K Awards: Review
Career Development PlanCareer Development Plan Activities other than research aloneActivities other than research alone
that will facilitate transition tothat will facilitate transition toindependenceindependence Additional coursework to fill-in gaps?Additional coursework to fill-in gaps?
Grant-writing workshops?Grant-writing workshops? Seminars, journal clubsSeminars, journal clubs Participation in K30 program?Participation in K30 program?
Mentored K Awards: ReviewMentored K Awards: Review
Research PlanResearch Plan Should include new research trainingShould include new research training
Hypothesis- vs. discovery-drivenHypothesis- vs. discovery-driven
Provide a logical path to research independenceProvide a logical path to research independence(away from mentor)(away from mentor)
Detailed experimental plan with potential pitfalls,Detailed experimental plan with potential pitfalls,expected outcomes, alternative approachesexpected outcomes, alternative approaches
(K99/R00: distinct research phases)(K99/R00: distinct research phases)
Mentored K Awards: ReviewMentored K Awards: Review
Institutional EnvironmentInstitutional Environment Necessary resources for proposedNecessary resources for proposed
research and career developmentresearch and career development Interactions with other investigatorsInteractions with other investigators Detail opportunities for research andDetail opportunities for research and
career developmentcareer development Institutional commitment to candidateInstitutional commitment to candidate
Helpful Hints for K AwardsHelpful Hints for K Awards
Read the FOA; contact program staff to discuss your Read the FOA; contact program staff to discuss your eligibility and proposed plan!eligibility and proposed plan!
Read the Instructions in the PHS 398 application kit!Read the Instructions in the PHS 398 application kit! Observe page limitationsObserve page limitations
Give yourself and your sponsor enough timeGive yourself and your sponsor enough time Give references enough timeGive references enough time Career Development Plan should be appropriateCareer Development Plan should be appropriate
Capable and experienced sponsor? Co-sponsor?Capable and experienced sponsor? Co-sponsor? Project should have merit as research and as career Project should have merit as research and as career
development mechanismdevelopment mechanism Arrange for pre-reviewArrange for pre-review
K02: Option for Res. or Clin. DegreeK02: Option for Res. or Clin. Degree
• Intended for newly independent scientistsIntended for newly independent scientists((some ICs require NIH support)some ICs require NIH support) whowhodemonstrate a need for a period of intensivedemonstrate a need for a period of intensiveresearch focus in order to enhance their research focus in order to enhance their
research careersresearch careers
• Limited NIH IC participationLimited NIH IC participation• May be renewableMay be renewable• Provides only salary & fringe benefit support;Provides only salary & fringe benefit support;
assumes other research support existsassumes other research support exists• Salary pro-rated [up to legislatively mandatedSalary pro-rated [up to legislatively mandatedmaximum rate - $191,300maximum rate - $191,300 (equal to ExecutiveLevel I)].
K24: Option for Patient ResearchK24: Option for Patient Research
• Provides clinician investigators protected timeProvides clinician investigators protected timeto devote to patient-oriented research & toto devote to patient-oriented research & toserve as research mentors for junior patient-serve as research mentors for junior patient-oriented researchersoriented researchers
•Protects between 25% and 50% of Protects between 25% and 50% of professional effortprofessional effort
• Candidate must engage in patient-orientedCandidate must engage in patient-orientedresearchresearch
• Salary pro-rated (up to legislatively mandatedSalary pro-rated (up to legislatively mandatedmaximum rate)maximum rate)
• Salary from other Federal sources OK for Salary from other Federal sources OK for non-K effortnon-K effort
• Nearly all ICs participateNearly all ICs participate
K05: Senior Scientist AwardK05: Senior Scientist Award
• Provides stability of support for well-Provides stability of support for well-established, outstanding scientists with highestablished, outstanding scientists with high
levels of productivity whose expertise islevels of productivity whose expertise is
critical to the mission of a particular NIH ICcritical to the mission of a particular NIH IC• Requires past record of NIH supportRequires past record of NIH support
• Requires peer-reviewed support at time of Requires peer-reviewed support at time of
awardaward
• Limited NIH IC participation (NCI, NCCAM,Limited NIH IC participation (NCI, NCCAM,
• Extramural ProgramsExtramural Programs – Health DisparitiesHealth Disparities
– Individuals from Disadvantaged BackgroundsIndividuals from Disadvantaged Backgrounds
– Contraception and InfertilityContraception and Infertility
– Pediatric ResearchPediatric Research
– Clinical ResearchClinical Research
• Researchers at 50% effort or more at non-profitResearchers at 50% effort or more at non-profitorganizations with qualifying educational debtorganizations with qualifying educational debt
• Payments to loaning institution up to $35,000 per year Payments to loaning institution up to $35,000 per year
• Pay tax on the loan paymentsPay tax on the loan payments• Concurrent service requirementConcurrent service requirement• Office of Loan Repayment Website:Office of Loan Repayment Website: http://www.lrp.nih.gov/http://www.lrp.nih.gov/
• Application Period: September - December Application Period: September - December
K Kiosk – NIH Career Development Awards:K Kiosk – NIH Career Development Awards: http://grants1.nih.gov/training/careerdevelopmentawards.htmhttp://grants1.nih.gov/training/careerdevelopmentawards.htm
Career Award Wizard:Career Award Wizard: http://grants1.nih.gov/training/kwizard/index.htmhttp://grants1.nih.gov/training/kwizard/index.htm
Determining Full-Time Professional Effort for Career Awards:Determining Full-Time Professional Effort for Career Awards:http://grants1.nih.gov/grants/guide/notice-files/NOT-OD-04-056.hhttp://grants1.nih.gov/grants/guide/notice-files/NOT-OD-04-056.h
Policy on Mentored K Award Salaries: Change In NIH PolicyPolicy on Mentored K Award Salaries: Change In NIH PolicyConcerning Concurrent Support From K Award and aConcerning Concurrent Support From K Award and aResearch Grant:Research Grant: http://grants1.nih.gov/grants/guide/notice-files/NOT-OD-04-007.hhttp://grants1.nih.gov/grants/guide/notice-files/NOT-OD-04-007.h