Bone Marrow Stem Cell Therapy for Macular Degeneration

David A. Steenblock, M.S., D.O.David A. Steenblock, M.S., D.O.

STEM CELL HEALING STEM CELL HEALING FOR MACULAR FOR MACULAR DEGENERATIONDEGENERATION

26381 Crown Valley Pkwy, St. 130, Mission Viejo, California USA. 1-800-300-106326381 Crown Valley Pkwy, St. 130, Mission Viejo, California USA. 1-800-300-1063

DISCLAIMERDISCLAIMER• NO FORM OF ADULT STEM CELL THERAPY NO FORM OF ADULT STEM CELL THERAPY

INCLUDING USE OF STEM CELL-RICH INCLUDING USE OF STEM CELL-RICH WHOLE BONE MATTER IS APPROVED OR WHOLE BONE MATTER IS APPROVED OR OTHERWISE SANCTIONED BY THE FDA. OTHERWISE SANCTIONED BY THE FDA. RESULTS SHARED IN THIS PRESENTATION RESULTS SHARED IN THIS PRESENTATION MAY NOT BE TYPICAL AND YOU MAY NOT MAY NOT BE TYPICAL AND YOU MAY NOT HAVE ANY RESULTS WHATSOEVER FROM A HAVE ANY RESULTS WHATSOEVER FROM A BONE MARROW TRANSPLANT OR ANY BONE MARROW TRANSPLANT OR ANY OTHER FORM OF STEM CELL USE. NO OTHER FORM OF STEM CELL USE. NO CLAIMS OR PROMISES ARE MADE OR CLAIMS OR PROMISES ARE MADE OR INFERRED.INFERRED.

About Dr. SteenblockAbout Dr. Steenblock

• MS biochemistry, Doctor of Osteopathy (D.O.) degreeMS biochemistry, Doctor of Osteopathy (D.O.) degree• World class diagnostician (Worked as a pathologist)World class diagnostician (Worked as a pathologist)• Expert in diet, nutrition, herbal medicine, hyperbaric Expert in diet, nutrition, herbal medicine, hyperbaric

medicine, chelation-detox, the use of adult medicine, chelation-detox, the use of adult (nonembryonic) stem cells(nonembryonic) stem cells

• Co-authored Co-authored ““Umbilical Cord Stem Cell TherapyUmbilical Cord Stem Cell Therapy”” • Created the stem cell mobilizer Created the stem cell mobilizer Stemgevity™ Stemgevity™ • Founder and President of Founder and President of Steenblock Research Steenblock Research

Institute,Institute, a nonprofit organization devoted to research a nonprofit organization devoted to research and education.and education.

Stem cells 101Stem cells 101

Stem CellsStem Cells

Your bodyYour body’’s tissues harbor stem s tissues harbor stem cells that help maintain, repair & cells that help maintain, repair & regenerate them over a lifetime.regenerate them over a lifetime.

What are Stem Cells?What are Stem Cells?• Unspecialized cells that can Unspecialized cells that can

become various somatic or body become various somatic or body cells, e.g., eye cells, skin cells, cells, e.g., eye cells, skin cells, liver cells, neurons, etc.liver cells, neurons, etc.

• Found in high number in your Found in high number in your bone marrowbone marrow

Bone Marrow Stem CellsBone Marrow Stem Cells

• Hematopoietic Hematopoietic • Mesenchymal Mesenchymal • Endothelial Endothelial

• These are stem cells they give rise to These are stem cells they give rise to blood cell types such as platelets, blood cell types such as platelets, disease-fighting macrophages & a host of disease-fighting macrophages & a host of others. When they leave the marrow others. When they leave the marrow and engraft in other tissues they tend to and engraft in other tissues they tend to become cells that support, heal & become cells that support, heal & restore.restore.

• Injuries, infections & other Injuries, infections & other damage in organs & tissues damage in organs & tissues releases a chemical signal that releases a chemical signal that summons stem cells from the summons stem cells from the bone marrow to repair these.bone marrow to repair these.

Stem CellsStem Cells• The more stem cells released into your The more stem cells released into your

blood stream, the more healing occurs.blood stream, the more healing occurs.• The healthier you are, the healthier The healthier you are, the healthier

your stem cells are.your stem cells are.• The more different types given at one The more different types given at one

time, the better the results i.e. time, the better the results i.e. hematopoietic, mesenchymal, hematopoietic, mesenchymal, epithelial, etc.epithelial, etc.

Bone MarrowBone Marrow• Children have at least 10 times more stem Children have at least 10 times more stem

cells per milliliter (ml) of bone marrow than cells per milliliter (ml) of bone marrow than adults have. Adults over age 40 tend to have adults have. Adults over age 40 tend to have a lot of senescent or less robust stem cells. a lot of senescent or less robust stem cells. Can they be revitalized? Yes!Can they be revitalized? Yes!

• Dr. Steenblock uses FDA approved stem cell Dr. Steenblock uses FDA approved stem cell mobilizers to purge devitalized stem cells out mobilizers to purge devitalized stem cells out of the bone marrow. It responds by of the bone marrow. It responds by producing new, robust stem cells! producing new, robust stem cells!

Mesenchymal Stem Cells (MSC)Mesenchymal Stem Cells (MSC)• MSCs produce bone cells, fat cells, MSCs produce bone cells, fat cells,

tendons, ligaments and muscle cells. tendons, ligaments and muscle cells. • They also produce the extracellular They also produce the extracellular

matrix that supports neurons and other matrix that supports neurons and other cells including those in the eye.cells including those in the eye.

• They have the inherent flexibility or They have the inherent flexibility or plasticity to become other cells types plasticity to become other cells types including retinal type cells.including retinal type cells.

Mesenchymal Stem Cells cont.Mesenchymal Stem Cells cont.

• MSCs have been shown to MSCs have been shown to produce liver cells, pancreatic produce liver cells, pancreatic cells, heart cells, kidney cells and cells, heart cells, kidney cells and neuron-like cells.neuron-like cells.

• When auto-immune issues are When auto-immune issues are present MSCs help suppress this.present MSCs help suppress this.

Treating Macular Degeneration Treating Macular Degeneration with stem cell-rich bone marrowwith stem cell-rich bone marrow

• Both hematopoietic and Both hematopoietic and mesenchymal stem cells are mesenchymal stem cells are extracted from the bone marrow extracted from the bone marrow and are then immediately given and are then immediately given back to the patient, either by back to the patient, either by intravenous (iv) means or intravenous (iv) means or retrobulbar injection or both. retrobulbar injection or both.

Whole Bone Marrow Whole Bone Marrow TransplantsTransplants

Bone Marrow HarvestingBone Marrow Harvesting

Bone Marrow HarvestingBone Marrow Harvesting

• A local anesthetic is used to deaden the A local anesthetic is used to deaden the harvesting area. harvesting area.

• Most of the time bone marrow is removed Most of the time bone marrow is removed from the tibia are large bone in the lower from the tibia are large bone in the lower leg. The procedures takes only a few hours.leg. The procedures takes only a few hours.

• Patients report feeling little if any pain or Patients report feeling little if any pain or discomfort.discomfort.

Two primary ways stem cell-rich Two primary ways stem cell-rich bone marrow is given for ARMDbone marrow is given for ARMD

• By IV: The bone marrow is given By IV: The bone marrow is given intravenously.intravenously.

• Retrobulbar injection: Cells are Retrobulbar injection: Cells are injected in tissues behind the eye. injected in tissues behind the eye.

Therapeutic measures that Therapeutic measures that complement the whole bone complement the whole bone

marrow transplants marrow transplants

Umbilical Cord Blood Stem Cells Umbilical Cord Blood Stem Cells • Umbilical cord blood contains Umbilical cord blood contains

many of the same kinds of stem many of the same kinds of stem cells as bone marrow.cells as bone marrow.

• Many doctors & researchers Many doctors & researchers believe that umbilical cord stem believe that umbilical cord stem cells reverses retinal pigment cells reverses retinal pigment epithelial dysfunction which is epithelial dysfunction which is one of the main causes of age-one of the main causes of age-related macular degeneration. related macular degeneration. Retinal pigment cells nourish Retinal pigment cells nourish retinal vision cells. retinal vision cells.

Graphic cms.gov.

Cord Blood Stem Cells cont.Cord Blood Stem Cells cont.

• In some instances Dr. Steenblock may refer a In some instances Dr. Steenblock may refer a ARMD patient to be treated with cord blood stem ARMD patient to be treated with cord blood stem cells outside the US (It is illegal for doctors to use cells outside the US (It is illegal for doctors to use cord blood stem cells to treat CP in the US.) cord blood stem cells to treat CP in the US.) Usually this is because both bone marrow & cord Usually this is because both bone marrow & cord blood stem cells are needed to achieve the blood stem cells are needed to achieve the greatest degree of healing & restoration possible. greatest degree of healing & restoration possible.

Hyperbaric Oxygen Therapy Hyperbaric Oxygen Therapy • When indicated Dr. Steenblock prescribes a When indicated Dr. Steenblock prescribes a

course of HBOT. This is oxygen given under course of HBOT. This is oxygen given under pressure in a HBO chamber. This treatment pressure in a HBO chamber. This treatment gets oxygen into parts of the body gets oxygen into parts of the body including the brain which reverses ischemia including the brain which reverses ischemia (blood flow is compromised) and hypoxia (blood flow is compromised) and hypoxia (lack of oxygen). (lack of oxygen).

Hyperbaric Oxygen Therapy Hyperbaric Oxygen Therapy continuedcontinued

• HBOT constricts blood HBOT constricts blood vessels and disrupts the vessels and disrupts the vicious cycle where a lack of vicious cycle where a lack of oxygen leads to tissue oxygen leads to tissue swelling, which then leads swelling, which then leads to further oxygen to further oxygen deficiency, etc. It also deficiency, etc. It also speeds up elimination of speeds up elimination of accumulated waste accumulated waste deposits in the retina called deposits in the retina called drusen, a player in ARMD. drusen, a player in ARMD.

Dr. SteenblockDr. Steenblock’’s 4-chamber s 4-chamber HBOT RoomHBOT Room

HBO and Stem CellsHBO and Stem Cells

• Hyperbaric oxygen releases stem cells from Hyperbaric oxygen releases stem cells from the bone marrow into the circulation.the bone marrow into the circulation.

• Hyperbaric oxygen treatments enhance the Hyperbaric oxygen treatments enhance the growth of the stem cells and their ability to growth of the stem cells and their ability to migrate into damaged tissues.migrate into damaged tissues.

• HBOT is typically given daily before and HBOT is typically given daily before and after stem cell treatments.after stem cell treatments.

Intravenous (IV) Treatments Intravenous (IV) Treatments • In some instances Dr. Steenblock In some instances Dr. Steenblock

determines that certain growth determines that certain growth factors, amino acids, vitamins, factors, amino acids, vitamins, minerals or other compounds minerals or other compounds will help encourage rapid will help encourage rapid healing of ARMD either before healing of ARMD either before or following a stem cell or following a stem cell treatment. Sometimes heavy treatment. Sometimes heavy metals need to be removed metals need to be removed using a chelating drug. These are using a chelating drug. These are given by IV drip as this gets them given by IV drip as this gets them into the circulation so they can into the circulation so they can go to work right away. go to work right away.

Customized IV cocktails

Enhanced External Enhanced External Counterpulsation (EECP)Counterpulsation (EECP)

• EECP is simple in concept but EECP is simple in concept but profound in its effects: A profound in its effects: A computer driven machine computer driven machine inflates large cuffs around the inflates large cuffs around the patientpatient’’s legs & waist whenever s legs & waist whenever the heart relaxes. This pushes the heart relaxes. This pushes blood back through arteries blood back through arteries opening them up. This increases opening them up. This increases blood & oxygen flow blood & oxygen flow throughout the body including throughout the body including the eyes. Lack of both the eyes. Lack of both characterizes ARMD.characterizes ARMD.

Periodic Acceleration TherapyPeriodic Acceleration Therapy• In PAT patients lying prone on a

motorized platform get a moderate cardiovascular work-out from a gentle back-and-forth motion. This creates a very mild stress on blood vessels that gets them busy producing Nitric Oxide (NO), a chemical that increases blood flow to organs and tissues body wide. It also mobilizes stem cells from bone marrow. ARMD benefits greatly from the influx of blood, oxygen & stem cells into their eyes.

Macular Degeneration Patient Macular Degeneration Patient Stories Stories

Video of Sam Smith

http://www.youtube.com/watch?http://www.youtube.com/watch?v=6Zr_UoSaQok v=6Zr_UoSaQok

From Dr. SteenblockFrom Dr. Steenblock’’s ARMD s ARMD patient files patient files

““The improvement in my vision was both The improvement in my vision was both dramatic and immediate. There was also dramatic and immediate. There was also an increase in my energy.an increase in my energy.””

Improvement in macula in two months Improvement in macula in two months after a whole bone marrow transplant.after a whole bone marrow transplant.

Additional stem cell information Additional stem cell information can be found in….can be found in….

• ““Umbilical Cord Stem Cell Umbilical Cord Stem Cell Therapy: The Gift of Therapy: The Gift of Healing from Healthy Healing from Healthy NewbornsNewborns””

• Get your copy from Get your copy from Amazon.com or from Dr. Amazon.com or from Dr. SteenblockSteenblock’’s Clinic at s Clinic at 1-800-300-10631-800-300-1063

Need more information? Visit Need more information? Visit our web sitesour web sites

• www.stemcellmd.org• www.strokedoctor.com• www.davidsteenblock.com • www.davidsteenblock.net • www.stemgevity.com

Ready to set up a phone Ready to set up a phone consultation or treatment consultation or treatment

appointment with Dr. Steenblock?appointment with Dr. Steenblock?• To arrange for a phone To arrange for a phone

consultation or to make consultation or to make a treatment a treatment appointment call 1-800-appointment call 1-800-300-1063 300-1063