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Hiba Nasir 1248129 Endocrinology Presentation
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Page 1: Blood dopping, defination, methods, detection, pros/cons.

Hiba Nasir

1248129

Endocrinology Presentation

Page 2: Blood dopping, defination, methods, detection, pros/cons.

BLOOD DOPING

Page 3: Blood dopping, defination, methods, detection, pros/cons.

Have you ever heard???

Page 4: Blood dopping, defination, methods, detection, pros/cons.

Doping?

• Adding impurities to something.

• Blood Doping

Page 5: Blood dopping, defination, methods, detection, pros/cons.

Blood Doping

• Increased red blood cells

• RBCs carry O2

• Higher RBC higher aerobic capacity

• Aerobic capacity (VO2 max)

Page 6: Blood dopping, defination, methods, detection, pros/cons.
Page 7: Blood dopping, defination, methods, detection, pros/cons.

Increment in hemoglobin mass

Page 8: Blood dopping, defination, methods, detection, pros/cons.

METHODS

Page 9: Blood dopping, defination, methods, detection, pros/cons.

Blood Transfusion

• 1-4 units

• centrifuged

• plasma components reinfused

• (RBCs),

refrigerated at 4◦C

frozen at −80◦C

Page 10: Blood dopping, defination, methods, detection, pros/cons.

Blood Transfusion

• Due to storage, 40% RBCs

non- viable.

• Stored RBCs are then

reinfused,

• iron supplements for

autologous donations.

Page 11: Blood dopping, defination, methods, detection, pros/cons.

Blood Transfusion Types

Autologous transfusion

• Own blood

Homologous transfusion

• Someone else blood

Page 12: Blood dopping, defination, methods, detection, pros/cons.

Blood Substitutes

• Synthetic oxygen carriers

human blood unavailable

blood infection

there isn't enough time to match of blood type

• Example

HBOCs

PFCs

Page 13: Blood dopping, defination, methods, detection, pros/cons.

HBOCs

• Resistance to dissociate when dissolved in media

• greater benefits than hemoglobin

• highly effective O2 donors in terms of tissue oxygenation

Page 14: Blood dopping, defination, methods, detection, pros/cons.

PFCs

• dissolve 100 times more oxygen than plasma.

• Small size = flow in tiny capillaries.

Page 15: Blood dopping, defination, methods, detection, pros/cons.

EPO Injections

• Hormone, produced by kidney.

• Regulates production of RBCs by acting on bone marrow.

• EPO injections are given to stimulate the production of RBCs to treat patients with anemia.

Page 16: Blood dopping, defination, methods, detection, pros/cons.

Athletes using EPO to produce higher than normal amounts of red blood

cells

Page 17: Blood dopping, defination, methods, detection, pros/cons.

DETECTION

Page 18: Blood dopping, defination, methods, detection, pros/cons.

Detection for Homologous Blood Doping

• Fluorescent-activated cell sorting

• Examining markers on the surface of rbcs

• Determine whether blood from more than one person is present

Page 19: Blood dopping, defination, methods, detection, pros/cons.

Detection for Autologous Blood doping

• CO rebreathing technique

• To measure the nonphysiologicincreases in hb mass

• O2-CO gas mixture inhalation for about 10-15mins

• By measuring the difference in carboxyhemoglobin concentration (hbco) before and after rebreathing total hb mass can be calculated.

Page 20: Blood dopping, defination, methods, detection, pros/cons.

Pros Of Blood Doping

• Affects the brain of the athlete,

• Athlete’s exercise endurance level

• Improve the health of athletes

• Benefits the athlete's long exercise

• No oxygen depletion and lactic acid formation.

Page 21: Blood dopping, defination, methods, detection, pros/cons.

Cons of blood doping

• Increased viscosity of the blood

• Risk of heart diseases

• Cerebral or pulmonary embolisms

• Weakened immune system, increases the risk of autoimmune diseases.

Page 22: Blood dopping, defination, methods, detection, pros/cons.

• Blood clots

• Deterioration of the Mind

• Negative mental effects

• EPO addicting drug

Page 23: Blood dopping, defination, methods, detection, pros/cons.

THANK YOU Any questions?