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Biological Treatments for Autism and PDDik Biological Treatments for Autism and PDD Third Edition Dr

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  • Biological Treatments for Autism and PDD

    Third Edition Dr. William Shaw

    With contributions by Bernard Rimland Ph.D., Bruce Semon M.D. Ph.D., Lisa Lewis Ph.D., Karyn Seroussi, and Pamela Scott

  • II Biological Treatments for Autism and PDD Dr. William Shaw

    DISCLAIMER

    This book is a summary of current research and medical therapies in use for the treatment of autism and PDD. The authors have written this book to serve as a guide to therapies and as a reference source for both professionals and nonprofessionals. All of this information is meant to be used under the care of the patient’s health care professional and the authors do not intend that the information in this book be considered as a prescription for medical therapy for anyone. Many of the therapies discussed in this book are relatively new and may be associated with risks that may not be known for decades. Every medical therapy has inherent risks. The reader and the medical professional who treats himself or his children are responsible for weighing the risks involved in any of the therapies reviewed in this book before instituting such therapies. Although the authors have exhaustively researched all sources to ensure the accuracy of the information in this book, we assume no responsibility for errors, inaccuracies, or omissions.

    Acknowledgements

    I would like to thank the following individuals who have assisted me in many different ways in this work: Steve and Sandy Passer, Sidney Baker M.D., Bernard Rimland Ph.D. at the Autism Research Institute, Ellen Bolte and Portia Iversen at the Cure Autism Now Foundation, William Crook M.D. of the International Health Foundation, Kelly Dorfman and Patricia Lemer at the Developmental Delay Registry, my teachers, especially Samuel Rogers Ph.D., D.V.M. for his outstanding instruction in basic biochemistry, and Ellen Kassen for her outstanding work in the laboratory. I would also like to thank the hundreds of other parents and professionals who supported and encouraged my work and offered me additional information that led to me to explore new therapies and theories. William Shaw Ph.D. Copyright 2008 by William Shaw Ph.D. All rights reserved. No part of this book may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording or by any informational storage or retrieval system except by a reviewer who may quote brief passages in a review to be printed in a magazine or newspaper without permission in writing from the publisher.

    Printed in the United States of America ISBN 0-9661238-1-6

  • Biological Treatments for Autism and PDD Dr. William Shaw III

    TABLE OF CONTENTS

    Chapter 1: Infections, antibiotics, and their relationship to autism and ADD: Alternative treatments. Is there an autism epidemic? The antibiotic revolution: Ear infections; Nonhuman use of antibiotics and the rise of antibiotic-resistant bacteria; Bacteria that causes ear infection; Vaccines; Ear infections and other recurrent infections and how to break the cycle or at least reduce the damage………….………………………...………….1 Chapter 2: The microorganisms in the gastrointestinal tract Bacteria in the intestinal tract; Yeast overgrowth of the intestinal tract; Evidence for abnormal bacterial byproducts in autism; HPHPA as a possible indicator of abnormal neurotransmitter formation; Control of clostridia overgrowth; Relationship between the immune system; early use of antibiotics and the microorganisms in the gastrointestinal tract……...…………………………………………………………..……….11

    Chapter 3: Organic acid testing, byproducts of yeast and their relationship to autism Metabolic disease testing: the history of organic acid testing; Evaluation of two brothers with autism, Evaluation of a third child with autism; Properties of tartaric acid; Arabinose and Candida; Other sources of arabinose; Arabinose, pentosidine, and protein crosslinks; Arabinose and impaired vitamin function; Pentosidines, tangled nerves, Alzheimer’s disease, and autism; Prevention of pentosidine formation with high doses of vitamin B-6 and other vitamins?……………………………………………………………..…………..…..23 Chapter 4: Yeasts and fungi: How to control them Diagnosis of yeast disorders;Stool testing; Organic acid test for yeast and bacterial byproducts; Blood tests for candida; Interactions of yeast and other bacteria; Antifungal therapies; Probiotics; Nonprescription Antifungal products; Diet to control yeast overgrowth; The yeast die-off or Herxheimer reaction. Garlic; Oregano; Caprylic acid and MCT oil; Colloidal silver; Lactoferrin; Combination products; Biotin; Biotinidase deficiency; Prescription antifungal products;Amphotericin B; How to administer nystatin.………………………………...…43 Chapter 5: Immune deficiency, food allergies, and yeast suppression of the immune system in autism Overview of the immune system; Antibodies or immunoglobulins; Cellular immunity; Types of immune deficiency that occur in autism; Myeloperoxidase deficiency; Severe combined immunodeficiency disease (SCID); Selective IgA deficiency; IgG subclass deficiency; Complement C4b deficiency; Gliotoxins and other immunotoxins produced by yeast and fungi; Other toxic byproducts of Candida; Autoimmunity, molecular mimicry, and Candida; The wheat and yeast connection; Therapies; Gamma globulin therapy. Insurance coverage for immune therapies; Cimetidine; Transfer factor therapy; Bovine colostrums; Pentoxifylline; IL-2; Allergic phenomena, food sensitivity, and altered behavior; Tests of allergies; Immunotherapy with enzyme- potentiated desensitization (EPD);Homeopathy; Treatment for allergic symptoms of wheat and dairy products; NAET…………………………………………………………………………………………………………….….…......59 Chapter 6: Abnormalities of the digestive system Gluten and casein sensitivity; Historical perspective; Antibodies to transglutaminase cause celiac disease; Differences between wheat sensitivity in autism and celiac disease; Testing for wheat and dairy sensitivity; Restriction of gluten and casein from the diet; Prevention of calcium deficiency on the casein free diet; Soy Sensitivity, Use of other therapies to control gluten and casein sensitivity; Other new peptides that may be important in autism; High-Protease/Peptidase Enzyme Products Enhance Protein Digestion; Alpha-1- antitrypsin deficiency; Pancreatic atrophy, hypoglycemia, and antibiotics; Secretin; Routes of administration and forms of secretin; Adverse reactions to secretin; CCK; Abnormal bile secretion; Tests of pancreatic function; Other digestive enzyme supplements; Behavior, food dyes and inactivation of digestive enzymes……………….……………………………………………………..……………………………………..….....75

  • IV Biological Treatments for Autism and PDD Dr. William Shaw

    Chapter 7: Immunizations and autism Congressional investigation of vaccine safety; A brief history of vaccines; A parent speaks out on vaccines; MMR vaccination and autism; Credibility gap of health care officials on vaccine reactions; Positive aspects of childhood diseases; Hepatitis B vaccine and autism; DPT vaccine and autism; The acellular pertussis vaccine; Reporting vaccine damage; Class action lawsuits in the United Kingdom; Vaccine damage fund in the United States; When to think about refusing vaccination; What factors to consider in delaying or omitting vaccination…………………………………………………………..………………………..………………..….……...95

    Chapter 8: Heavy Metals Toxicity Heavy metals, especially mercury, implicated in autism and learning disabilities; What is mercury? Health effects of mercury and recurrent Candida; Other heavy metals; Treatments of mercury toxicity; How to decide which test is most appropriate for metals testing; Side effects of DMSA; Treatment for heavy metal toxicity; DMSA treatment; Lipoic acid; PCA; Tests available from the Great Plains Laboratory …………………………...........................................................………………………………………….…………. 107

    Chapter 9: Inborn Errors of Metabolism as Causes of Autism Abnormal purine and pyrimidine metabolism in autism: new tests and treatments for people with unique subtypes of autism and PDD; Dihydropyrimidine dehydrogenase deficiency; Low urine uric acid and elevated nucleotidase in autism: A subtype of autism that responds to dietary pyrimidine supplementation; High uric acid and autism: A subtype of autism that responds to dietary restriction of purines and/or allopurinol; Abnormal succinylpurines and autism; Testing…………………………………………………………….……..…113

    Chapter 10: Frequently Asked Questions………………….……………………….…..…………….….…….…119 Chapter 11: The Use of Vitamin B6, Magnesium, and DMG in the Treatment of Children and Adults with Autism, by Bernard Rimland Ph.D. Vitamin B6 (and magnesium) in the treatment of autism; Vitamin B6 in autism: the safety issue; Dimethylglycine (DMG), a nontoxic metabolite, and autism. ………………………………………………..……127 Chapter 12: Treating yeast in children with autism: typical results of anti-yeast therapy, by Bruce