Basic Human Pathology - Lecture 6

1. Basic Human Pathology Lecture #6 Acute Inflammation / Wound ...

2. Acute Inflammatory Response

Tufts OpenCourseWare © 2008 Tufts University

Acute Inflammation/Wound Healing and Repair II

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 1

3. Acute Inflammatory Response

4. Biphasic Permeability Response

Tufts OpenCourseWare © 2008 Tufts University

Acute Inflammation/Wound Healing and Repair II

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 2

5. Acute Inflammation Mechanisms

6. Demonstration of Transient Vasoconstriction

Tufts OpenCourseWare © 2008 Tufts University

Acute Inflammation/Wound Healing and Repair II

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 3

7. Circulatory Changes in Inflammation

8. Dilation of Capillaries and Postcapillary Venules in Inflamm...

Tufts OpenCourseWare © 2008 Tufts University

Acute Inflammation/Wound Healing and Repair II

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 4

9. Acute Inflammation Mechanisms

10. Acute Inflammation Mechanisms

Tufts OpenCourseWare © 2008 Tufts University

Acute Inflammation/Wound Healing and Repair II

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 5

11. Morphologic Reaction of Endothelial Cells to Injury

12. Increased Permeability of Vessels Due to Various Indicated F...

Tufts OpenCourseWare © 2008 Tufts University

Acute Inflammation/Wound Healing and Repair II

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 6

13. Patterns of Permeability Response

14. Patterns of Permeability Response

Tufts OpenCourseWare © 2008 Tufts University

Acute Inflammation/Wound Healing and Repair II

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 7

15. Various Mechanisms Underlying Increased Vascular Permeabilit...

16. Acute Inflammation Mechanisms

Tufts OpenCourseWare © 2008 Tufts University

Acute Inflammation/Wound Healing and Repair II

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 8

17. Acute Inflammation Mechanisms

18. Biochemical Events in Leukocyte Activation

Tufts OpenCourseWare © 2008 Tufts University

Acute Inflammation/Wound Healing and Repair II

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 9

19. Cellular Changes in Inflammation

20. Acute Inflammation Mechanisms

Tufts OpenCourseWare © 2008 Tufts University

Acute Inflammation/Wound Healing and Repair II

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 10

21. Acute Inflammation Mechanisms

22. Acute Inflammation Mechanisms

Tufts OpenCourseWare © 2008 Tufts University

Acute Inflammation/Wound Healing and Repair II

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 11

23. Acute Inflammation Mechanisms

24. Emigration

Tufts OpenCourseWare © 2008 Tufts University

Acute Inflammation/Wound Healing and Repair II

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 12

25. Emigration

26. Adhesion of Neutrophils to Endothelial Cells by Surface Mole...

Tufts OpenCourseWare © 2008 Tufts University

Acute Inflammation/Wound Healing and Repair II

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 13

27. Three General Mechanisms

28. Sequence of Events in Inflammatory Leukocyte Emigration

Tufts OpenCourseWare © 2008 Tufts University

Acute Inflammation/Wound Healing and Repair II

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 14

29. Emigration of Neutrophils

30. A Vascular and Cellular Response

Tufts OpenCourseWare © 2008 Tufts University

Acute Inflammation/Wound Healing and Repair II

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 15

31. Acute Inflammation Mechanisms

32. Acute Inflammation Mechanisms

Tufts OpenCourseWare © 2008 Tufts University

Acute Inflammation/Wound Healing and Repair II

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 16

33. Chemotactic Factors or Mediators

34. Chemotaxis

Tufts OpenCourseWare © 2008 Tufts University

Acute Inflammation/Wound Healing and Repair II

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 17

35. Chemotactic Factors

36. Acute Inflammation Mechanisms

Tufts OpenCourseWare © 2008 Tufts University

Acute Inflammation/Wound Healing and Repair II

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 18

37. Acute Inflammation Mechanisms

38. Phagocytosis of a Particle

Tufts OpenCourseWare © 2008 Tufts University

Acute Inflammation/Wound Healing and Repair II

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 19

39. Acute Inflammation Mechanisms

40. Acute Inflammation Mechanisms

Tufts OpenCourseWare © 2008 Tufts University

Acute Inflammation/Wound Healing and Repair II

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 20

41. Steps in Phagocytosis

42. Acute Inflammation Mechanisms

Tufts OpenCourseWare © 2008 Tufts University

Acute Inflammation/Wound Healing and Repair II

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 21

43. Chemical Mediators of Inflammation

44. Chemical Mediators, Sources and Possible Actions

Tufts OpenCourseWare © 2008 Tufts University

Acute Inflammation/Wound Healing and Repair II

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 22

45. Chemical Mediators, Sources, and Possible Actions

46. Chemical Mediators, Sources, and Possible Actions

Tufts OpenCourseWare © 2008 Tufts University

Acute Inflammation/Wound Healing and Repair II

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 23

47. The Lymphatics in Acute Inflammation

48. Hereditary Defects that Impair the Acute Inflammatory Respon...

Tufts OpenCourseWare © 2008 Tufts University

Acute Inflammation/Wound Healing and Repair II

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 24

49. Hereditary Defects that Impair the Acute Inflammatory Respon...

50. Neutropenia Resulting in Periodontal Disease and Mucosal Ulc...

Tufts OpenCourseWare © 2008 Tufts University

Acute Inflammation/Wound Healing and Repair II

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 25

51. Oral Inflammation, Infections, Ulcerations

52. Hereditary Defects that Impair the Acute Inflammatory Respon...

Tufts OpenCourseWare © 2008 Tufts University

Acute Inflammation/Wound Healing and Repair II

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 26

53. Hereditary Defects that Impair the Acute Inflammatory Respon...

54. Leukocyte Function Defects

Tufts OpenCourseWare © 2008 Tufts University

Acute Inflammation/Wound Healing and Repair II

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 27

55. Outcome of the Acute Inflammatory Reaction

56. Tissue Damage of Necrosis

Tufts OpenCourseWare © 2008 Tufts University

Acute Inflammation/Wound Healing and Repair II

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 28

57. Outcome of the Acute Inflammatory Reaction

58. Outcome of the Acute Inflammatory Reaction

Tufts OpenCourseWare © 2008 Tufts University

Acute Inflammation/Wound Healing and Repair II

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 29

59. Resolution Occurring in Pneumonia

60. Outcome of the Acute Inflammatory Reaction

Tufts OpenCourseWare © 2008 Tufts University

Acute Inflammation/Wound Healing and Repair II

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 30

61. Outcome of the Acute Inflammatory Reaction

62. Outcome of the Acute Inflammatory Reaction

Tufts OpenCourseWare © 2008 Tufts University

Acute Inflammation/Wound Healing and Repair II

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 31

63. Outcome of the Acute Inflammatory Reaction

64. Outcome of the Acute Inflammatory Reaction

Tufts OpenCourseWare © 2008 Tufts University

Acute Inflammation/Wound Healing and Repair II

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 32

65. Removal of Debris by Macrophages

66. Vascular Granulation Tissue

Tufts OpenCourseWare © 2008 Tufts University

Acute Inflammation/Wound Healing and Repair II

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 33

67. Fibrovascular Granulation Tissue

68. Early Collagenous Scar

Tufts OpenCourseWare © 2008 Tufts University

Acute Inflammation/Wound Healing and Repair II

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 34

69. Outcome of the Acute Inflammatory Reaction

70. Outcome of the Acute Inflammatory Reaction

Tufts OpenCourseWare © 2008 Tufts University

Acute Inflammation/Wound Healing and Repair II

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 35

71. Outcome of the Acute Inflammatory Reaction

72. Outcome of the Acute Inflammatory Reaction –

Tufts OpenCourseWare © 2008 Tufts University

Acute Inflammation/Wound Healing and Repair II

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 36

73. Outcome of the Acute Inflammatory Reaction –

74. Outcome of the Acute Inflammatory Reaction –

Tufts OpenCourseWare © 2008 Tufts University

Acute Inflammation/Wound Healing and Repair II

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 37

75. Outcome of the Acute Inflammatory Reaction –

76. Outcome of the Acute Inflammatory Reaction –

Tufts OpenCourseWare © 2008 Tufts University

Acute Inflammation/Wound Healing and Repair II

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 38

77. Outcome of the Acute Inflammatory Reaction –

78. Outcome of the Acute Inflammatory Reaction

Tufts OpenCourseWare © 2008 Tufts University

Acute Inflammation/Wound Healing and Repair II

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 39

79. Outcome of the Acute Inflammatory Reaction

Tufts OpenCourseWare © 2008 Tufts University

Acute Inflammation/Wound Healing and Repair II

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 40