Expanded and highly active proliferation centers identify a histological subtype of chronic lymphocytic leukemia (“accelerated“ chronic lymphocytic leukemia) with aggressive clinical behavior by Eva Giné, Antonio Martinez, Neus Villamor, Armando Lopez-Guillermo, Mireia Camos, Daniel Martinez, Jordi Esteve, Xavier Calvo, Ana Muntañola, Pau Abrisqueta, Maria Rozman, Ciril Rozman, Francesc Bosch, Elias Campo, and Emili Montserrat Haematologica 2010 [Epub ahead of print] Citation: Giné E, Martinez A, Villamor N, Lopez-Guillermo A, Camos M, Martinez D, Esteve J, Calvo X, Muntañola A, Abrisqueta P, Rozman M, Rozman C, Bosch F, Campo E, and Montserrat E. Expanded and highly active proliferation centers identify a histological subtype of chronic lymphocytic leukemia (“accelerated” chronic lymphocytic leukemia) with aggressive clinical behavior.Haematologica. 2010; 96:xxx doi:10.3324/haematol.2010.022277 Publisher's Disclaimer. E-publishing ahead of print is increasingly important for the rapid dissemination of science. Haematologica is, therefore, E-publishing PDF files of an early version of manuscripts that have completed a regular peer review and have been accepted for publication. E-publishing of this PDF file has been approved by the authors. After having E-published Ahead of Print, manuscripts will then undergo technical and English editing, typesetting, proof correction and be presented for the authors' final approval; the final version of the manuscript will then appear in print on a regular issue of the journal. All legal disclaimers that apply to the journal also pertain to this production process. Haematologica (pISSN: 0390-6078, eISSN: 1592-8721, NLM ID: 0417435, www.haemato- logica.org) publishes peer-reviewed papers across all areas of experimental and clinical hematology. The journal is owned by the Ferrata Storti Foundation, a non-profit organiza- tion, and serves the scientific community with strict adherence to the principles of open access publishing (www.doaj.org). In addition, the journal makes every paper published immediately available in PubMed Central (PMC), the US National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature. Official Organ of the European Hematology Association Published by the Ferrata Storti Foundation, Pavia, Italy www.haematologica.org Early Release Paper Support Haematologica and Open Access Publishing by becoming a member of the European Hematology Association (EHA) and enjoying the benefits of this membership, which include free participation in the online CME program Copyright 2010 Ferrata Storti Foundation. Published Ahead of Print on April 26, 2010, as doi:10.3324/haematol.2010.022277.
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Expanded and highly active proliferation centers identify a histological subtype of chronic lymphocytic leukemia (“accelerated“ chronic lymphocytic leukemia) with aggressive clinical behavior
by Eva Giné, Antonio Martinez, Neus Villamor, Armando Lopez-Guillermo,Mireia Camos, Daniel Martinez, Jordi Esteve, Xavier Calvo, Ana Muntañola,Pau Abrisqueta, Maria Rozman, Ciril Rozman, Francesc Bosch, Elias Campo,and Emili Montserrat
Haematologica 2010 [Epub ahead of print]
Citation: Giné E, Martinez A, Villamor N, Lopez-Guillermo A, Camos M, Martinez D,Esteve J, Calvo X, Muntañola A, Abrisqueta P, Rozman M, Rozman C, Bosch F, Campo E,and Montserrat E. Expanded and highly active proliferation centers identify a histologicalsubtype of chronic lymphocytic leukemia (“accelerated” chronic lymphocytic leukemia) withaggressive clinical behavior.Haematologica. 2010; 96:xxx doi:10.3324/haematol.2010.022277
Publisher's Disclaimer.E-publishing ahead of print is increasingly important for the rapid dissemination of science.Haematologica is, therefore, E-publishing PDF files of an early version of manuscripts thathave completed a regular peer review and have been accepted for publication. E-publishingof this PDF file has been approved by the authors. After having E-published Ahead of Print,manuscripts will then undergo technical and English editing, typesetting, proof correction andbe presented for the authors' final approval; the final version of the manuscript will thenappear in print on a regular issue of the journal. All legal disclaimers that apply to the journal also pertain to this production process.
Haematologica (pISSN: 0390-6078, eISSN: 1592-8721, NLM ID: 0417435, www.haemato-logica.org) publishes peer-reviewed papers across all areas of experimental and clinicalhematology. The journal is owned by the Ferrata Storti Foundation, a non-profit organiza-tion, and serves the scientific community with strict adherence to the principles of openaccess publishing (www.doaj.org). In addition, the journal makes every paper publishedimmediately available in PubMed Central (PMC), the US National Institutes of Health (NIH)free digital archive of biomedical and life sciences journal literature.
Official Organ of the European Hematology AssociationPublished by the Ferrata Storti Foundation, Pavia, Italy
www.haematologica.org
Early Release Paper
Support Haematologica and Open Access Publishing by becoming a member of the European Hematology Association (EHA)and enjoying the benefits of this membership, which include free participation in the online CME program
Copyright 2010 Ferrata Storti Foundation.Published Ahead of Print on April 26, 2010, as doi:10.3324/haematol.2010.022277.
DOI: 10.3324/haematol.2010.022277
Expanded and highly active proliferation centers identify a histological
subtype of chronic lymphocytic leukemia (“accelerated” chronic
lymphocytic leukemia) with aggressive clinical behavior
Running title: Accelerated CLL
Eva Giné,1 Antoni Martinez,2 Neus Villamor,2 Armando López-Guillermo,1
Mireia Camos,2 Daniel Martinez,2 Jordi Esteve,1 Xavier Calvo,1 Ana Muntañola,1
Pau Abrisqueta,1 Maria Rozman,2 Ciril Rozman,1 Francesc Bosch,1
Elias Campo,2 and Emili Montserrat1
1Hematology Department, Institute of Hematology and Oncology, Hospital
Clinic, Barcelona, Spain, and 2Hematopathology Unit, Hospital Clínic,
Barcelona, Spain
Correspondence
Francesc Bosch, MD, Department of Hematology, Hospital Clínic Villarroel
nº 170, 08036-Barcelona, Spain. Phone: international +34.93.2275475.
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Table 1. Initial characteristics of 100 patients with CLL.
M: Male; F: Female. * Available in 88, 74, 63, 61, 37 and 27