A. Aghamohammadi, N. Rezaei, Mouse Models of Allergic Mouse … · 2013-05-07 · A. Aghamohammadi, N. Rezaei, Tehran University of Medical Sciences, Iran (Eds) Clinical Cases in

Biomedicine springer.com/NEWSonline

62

A. Aghamohammadi, N. Rezaei, Tehran University of Medical Sciences, Iran (Eds)

Clinical Cases in Primary Immunodeficiency DiseasesA Problem-Solving Approach

Primary immunodeficiency diseases (PIDs) are a heterogeneous group of inherited disorders characterized by different defects in the develop-ment and function of the immune system. This book aims to increase the clinical awareness and knowledge of practicing clinicians regarding the diagnosis and management of PIDs. In order to achieve this goal, about 90 cases drawn from real life are presented, along with approximately 300 related questions. The selected case reports are the result of the invaluable cooperation of more than 40 scientists in the field of immunodeficiency. They focus both on the presenting features of patients with PIDs and on the required further investigation and management.

Features 7 Designed as a practical, awareness-raising guide for the clinician 7 Provides key informa-tion relevant to the diagnosis and management of each primary immunodeficiency (PID) 7 Com-prises a series of case-oriented problems drawn from typical patient scenarios 7 Enables prompt recognition of PIDs, thereby helping to avoid delayed diagnosis and its consequences

Contents Recurrent infections.- Combined T- and B-cell immunodeficiencies.- Primary Antibody Deficien-cies.- Disorders of Phagocytic Cells.- Immune dys-regulation diseases.- Defects in Innate immunity: Receptors and Signaling Components.- Autoin-flammatory disorders.- Complement deficiencies.- Other well-defined immunodeficiency syndromes.

Fields of interestImmunology; Allergology; Pediatrics

Target groupsProfessional/practitioner

Product categoryContributed volume

Available

2013. XIX, 377 p. 31 illus., 19 in color. Hardcover7 * € (D) 160,45 | € (A) 164,94 | sFr 200,007 € 149,95 | £135.00ISBN 978-3-642-31784-2

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I. C. Allen, Virginia Tech, Blacksburg, VA, USA (Ed)

Mouse Models of Allergic DiseaseMethods and Protocols

Contents Transgenic Mouse Models.- Pulmonary Antigen Presenting Cells: Isolation, Purification, and Culture.- Evaluation of T Cell Function in Allergic Disease.- Evaluating B-Cells: From Bone Marrow Precursors to Antibody Producing Cells.- Proto-cols for Identifying, Enumerating and Assessing Mouse Eosinophils.- Evaluation of Classical, Alternative, and Regulatory Functions of Bone Marrow-Derived Macrophages.- Applications of Mouse Airway Epithelial Cell Culture for Asthma Research.- Isolation and Characterization of Mast Cells in Mouse Models of Allergic Diseases.- Puri-fying and Measuring Immunoglobulin E (IgE) and Anti-IgE.- Protocols for the Induction and Evalu-ation of Systemic Anaphylaxis in Mice.- Contact Hypersensitivity Models in Mice.- Induction of Allergic Rhinitis in Mice.- Induction of Allergic Airway Disease Using House Dust Mite Allergen.- An Inhalation Model of Allergic Fungal Asthma: Aspergillus fumigatus-Induced Inflammation and Remodeling in Allergic Airways Disease.- PAMPs and DAMPs in Allergy Exacerbation Models.- Assessment of Airway Hyperresponsiveness in Mouse Models of Allergic Lung Disease Using Detailed Measurements of Respiratory Mechan-ics.- Bilateral Vagotomy as a Tool for Determining Autonomic Involvement in Airway Responses in Mouse Models of Asthma.- Clara Epithelial Cell Depletion in the Lung.- A Mouse Model for Evaluating the Contribution of Fibrocytes and Myofibroblasts to Airway Remodeling in Allergic Asthma.- Assessment of Airway Hyperresponsive-ness in Murine Tracheal Rings. [...]

Field of interestImmunology



Due June 2013

2013. XIV, 346 p. 51 illus., 27 in color. (Methods in Molecular Biology, Volume 1032) Hardcover7 * € (D) 117,69 | € (A) 120,99 | sFr 146,507 € 109,99 | £99.00ISBN 978-1-62703-495-1

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I. C. Allen, Virginia Tech, Blacksburg, VA, USA (Ed)

Mouse Models of Innate ImmunityMethods and Protocols

Contents Conventional Murine Gene Targeting.- Produc-tion and Characterization of Humanized Rag2-/-γc-/- Mice.- Isolation, Culture, and Functional Evaluation of Bone Marrow-Derived Macro-phages.- Collecting Resident or Thioglycollate Elicited Peritoneal Macrophages.- Quantification and Visualization of Neutrophil Extracellular Traps (NETs) from Murine Bone Marrow-Derived Neutrophils.- Assessment of Oxidative Metabo-lism.- Generation and Culture of Mouse Embry-onic Fibroblasts.- Primary Ear Fibroblast Deriva-tion from Mice.- Bone Marrow Derived Dendritic Cells.- Measuring T Cell Function in Innate Immune Models.- Bioassay for the Measurement of Type-I Interferon Activity.- Safe and Effec-tive Mouse Foot-Pad Inoculation.- Delayed Type Hypersensitivity Models in Mice.- Mouse Model of Staphylococcus aureus Skin Infection.- Sepsis Induced by Cecal Ligation and Puncture.- System-ic Infection of Mice with Listeria monocytogenes to Characterize Host Immune Responses.- Mouse Model of Invasive Fungal Infection.- Endotoxin-Induced Uveitis in Rodents.- Bacteria-Mediated Acute Lung Inflammation.- Intranasal Influ-enza Infection of Mice and Methods to Evaluate Progression and Outcome.- Dextran Sodium Sulfate-Induced Murine Inflammatory Colitis Model.- Bacterial-Mediated Gastrointestinal In-flammation.- Plasmodium berghei ANKA (PbA) Infection of C57BL/6J Mice: A Model of Severe Malaria.- Characterization of HIV-1 Infection in the Humanized Rag2-/-γc-/- Mouse Model.

Field of interestImmunology



Due June 2013

2013. XII, 258 p. 27 illus., 20 in color. (Methods in Molecular Biology, Volume 1031) Hardcover7 * € (D) 101,64 | € (A) 104,49 | sFr 126,507 € 94,99 | £85.50ISBN 978-1-62703-480-7

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www.springer.com/978-3-642-31784-2



News 5/2013 Biomedicine

63

M. R. Banghart, Harvard Medical School, Boston, MA, USA (Ed)

Chemical NeurobiologyMethods and Protocols

Features 7 Includes cutting-edge methods and proto-cols 7 Provides step-by-step detail essential for reproducible results 7 Contains key notes and implementation advice from the experts

Contents Engineering K+ Channels using Semisynthesis.- Chemical Derivatization and Purification of Pep-tide-Toxins for Probing Ion Channel Complexes.- Using Yeast to Study Potassium Channel Function and Interactions with Small Molecules.- A FLIPR Assay for Evaluating Agonists and Antagonists of GPCR Heterodimers.- Characterizing Caged Molecules Through Flash Photolysis and Transient Absorption Spectroscopy.- Characterization of One- and Two- Photon Photochemical Uncaging Efficiency.- Photochromic Potassium Channel Blockers: Design and Electrophysiological Char-acterization.- A 1H NMR Assay for Measuring the Photostationary States of Photoswtichable Ligands.- Developing a Photoreactive Antago-nist.- Development and in vitro Characterization of Ratiometric and Intensity-based Fluorescent Ion Sensors.- Characterization of Voltage-Sensitive Dyes in Living Cells using Two-Photon Excitation.- Characterization and Validation of Fluorescent Receptor Ligands: A Case Study of the Ionotropic Serotonin Receptor.- Imaging Single Synaptic Vesicles in Mammalian Central Synapses with Quantum Dots.- Directed Evolution of Protein-Based Neurotransmitter Sensors for MRI.

Fields of interestNeurosciences; Neurobiology



Available

2013. X, 202 p. 70 illus., 1 in color. (Methods in Molecular Biology, Volume 995) Hardcover7 * € (D) 101,64 | € (A) 104,49 | sFr 126,507 € 94,99 | £85.50ISBN 978-1-62703-344-2

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J. Bartunkek, M. Vanderheyden, OLV Hospital, Aalst, Belgium (Eds)

Translational Approach to Heart FailureContents Pathophysiology of Heart Failure: Back to Ba-sics.- Heart Failure with Normal Left Ventricular Ejection Fraction – Basic Principles and Clinical Diagnostics.- 17 Cardiorenal Syndrome Revis-ited.- Doppler Echocardiography in the Clinical Evaluation of Heart Failure: What Clinicians Need to know and Echocardiographers Should Report.- Back to Earth: ‘Common sense’ in the Management of Heart Failure.- Atrial Fibrillation and Heart Failure: Rate versus Rhythm Control.- Repetitive ICD Shocks and Incessant VTs in Heart Failure: What to Do?.- Dyssynchronous Heart Failure: From Bench to Bedside.- 18 Telemonitor-ing and Sensor Technologies in Chronic Heart Failure.- Functional Mitral Regurgitation: the Surgeons’s Perspective.- Percutaneous Approaches to Treat Functional Mitral Regurgitation: Current State of Affairs and Future Perspectives.- Tailored Approach to Functional Mitral Regurgitation.- Revascularization and Left Ventricular Recon-struction in a Patient with Ischemic Heart Failure: to STICH or not to STICH?.- Cardiac arrest en Refractory Cardiogenic Shock.- Left Ventricular Assist Devices – From Bridge to Transplant to Destination Therapy.- Novel Device-based Strate-gies in Treatment of Chronic Heart Failure.- Total Artificial Heart.- Stem Cell Therapy for Ischemic Heart Disease.- Immunosuppressive Management of the Heart Transplant Recipient.

Fields of interestBiomedicine general; Biomedical Engineering; Cardiology



Due June 2013

2013. XV, 475 p. 125 illus., 90 in color. Hardcover7 * € (D) 160,49 | € (A) 164,99 | sFr 200,007 € 149,99 | £135.00ISBN 978-1-4614-7344-2

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A. Boullerne, University of Illinois at Chicago, IL, USA; D. Osterhout, SUNY Upstate Medical University, Syracuse, NY, USA

Methods of Glial Cell CultureSome glia function primarily as physical support for neurons. Others regulate the internal environ-ment of the brain, especially the fluid surrounding neurons and their synapses, and provide nutrition to nerve cells. Glia have important developmen-tal roles, guiding migration of neurons in early development and producing molecules that modify the growth of axons and dendrites. Recent findings in the hippocampus and cerebellum have indicated that glia are also active participants in synaptic transmission, regulating clearance of neurotransmitter from the synaptic cleft, releasing factors such as ATP which modulate presynaptic function, and even releasing neurotransmitters themselves. This book outlines detailed methods for the isolation, purification and propagation of glial cells, such as oligodendrocytes, astrocytes, microglia and Schwann cells. This fills a major void in the methodology publications, as most books on neural cell cultures are focused on neu-ronal cell culture. Their protocols for glial cultures are too succinct to be useful to a glial cell biologist, either novice or established.

Features 7 Outlines detailed methods for the isolation, purification and propagation of glial cells, such as oligodendrocytes, astrocytes, microglia and Schwann cells 7 Fills a major void in the meth-odology publications 7 Up-to-date research is valuable to both clinicians and scientists alike

Contents Oligodendrocytes.- Astrocytes.- Microglia.- Schwann Cells.- Neuron-Glia Co-cultures.- Neu-rospheres.- Immortalization of Primary Cells

Field of interestNeurosciences

Target groupsResearch

Product categoryMonograph

Due June 2013

2013. 210 p. 150 illus., 60 in color. Hardcover7 approx. * € (D) 80,20 | € (A) 82,45 | sFr 107,507 approx. € 74,95 | £67.99ISBN 978-1-4614-5923-1

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64

T. J. Cleophas, European College Pharmaceutical Medicine, Lyon, France; A. H. Zwinderman, European Interuniversity College of Pharmaceutical Medicine, Lyon, France

Machine Learning in MedicinePart Two

Features 7 Electronic health records of modern health facilities, are increasingly complex and systematic assessment of these records is virtually impos-sible without special computationally intensive methods 7 Clinicians and other health profes-sionals are not familiar with these methods, and this book is the first publication that systemati-cally reviews such methods, particularly, for this audience 7 The book is written as a hand-hold presentation also accessible to non-mathemati-cians, and as a must-read publication for those new to the methods 7 The book includes step by step data analyses in SPSS, and can, therefore, also be used as a cookbook-like guide for those starting with the novel methodologies

Contents Introduction to Machine Learning Part Two.- Two-stage Least Squares.- Multiple Imputa-tions.- Bhattacharya Analysis.- Quality-of-life (QOL) Assessments with Odds Ratios.- Logistic Regression for Assessing Novel Diagnostic Tests against Control.- Validating Surrogate Endpoints.- Two-dimensional Clustering.- Multidimensional Clustering.- Anomaly Detection.- Association Rule Analysis.- Multidimensional Scaling.- Cor-respondence Analysis.- Multivariate Analysis of Time Series.- Support Vector Machines.- Bayesian Networks.- Protein and DNA Sequence Min-ing.- Continuous Sequential Techniques.- Discrete Wavelet Analysis.- Machine Learning and Com-mon Sense.- Statistical Tables.- Index.

Fields of interestBiomedicine general; Entomology; Medicine/Pub-lic Health, general

Target groupsPopular/general

Product categoryGraduate/Advanced undergraduate textbook

Due June 2013

2013. XII, 216 p. 47 illus., 24 in color. Hardcover7 * € (D) 74,89 | € (A) 76,99 | sFr 93,507 € 69,99 | £62.99ISBN 978-94-007-6885-7

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C. J. Crasto, University of Alabama at Birmingham, AL, USA (Ed)

Olfactory ReceptorsMethods and Protocols

Contents Databases in SenseLab for the Genomics, Proteomics, and Function of Olfactory Recep-tors.- HORDE: Comprehensive Resource for Olfactory Receptor Genomics.- Identification of Olfactory Receptor Genes from Mammalian Genome Sequences.- Molecular Modelling of Odorant / Olfactory Receptor Complexes.- The Electrical Properties of Olfactory Receptors in the Development of Biological Smell Sensors.- A Hit Map-Based Statistical Method to Predict Best Ligands for Orphan Olfactory Receptors: Natural Key Odorants Versus ‘Lock Picks’.- A Robust, Rapid, and Simple Method of Producing Olfactory Receptors Using Commercial E. coli Cell-Free Systems.- Human Olfactory Receptors: Recombinant Expression in the Baculovirus / Sf9 Insect Cell System, Functional Characterization, and Odorant Identification.- Single Cell RT-PCR Identification of Odorant Receptors Expressed by Olfactory Neurons.- Next-Generation Sequencing of the Human Olfactory Receptors.- Deciphering Activation of Olfactory Receptors Using Heter-ologous Expression in Saccharomyces cerevisiae and Bioluminescence Resonance Energy Transfer (BRET).- Olfactory Receptors in Human Airway Epithelia.- Functional Characterization of Insect Olfactory Receptor Neurons Through In Vivo Approaches.- Functional Assay of Mammalian and Insect Olfactory Receptors Using Xenopus Oocytes.- Pharmacology of Mammalian Olfac-tory Receptors.- Visualizing Olfactory Receptor Expression and Localization in Drosophila.- Deor-phanization of Human Olfactory Receptors by Luciferase and Ca-Imaging Methods.- Evolution of Olfactory Receptors.

Fields of interestHuman Genetics; Animal Genetics and Genomics



Due April 2013

2013. XIII, 259 p. 63 illus., 25 in color. (Methods in Molecular Biology, Volume 1003) Hardcover7 * € (D) 101,64 | € (A) 104,49 | sFr 126,507 € 94,99 | £85.50ISBN 978-1-62703-376-3

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Current Topics in Microbiology and ImmunologyR. W. Compans, M. D. Cooper, F. Melchers, Series editors: M. B. Oldstone, P. K. Vogt, T. Honjo, Y. Y. Gleba, B. Malissen, Y. Kawaoka, K. Aktories, R. Rappuoli, J. E. Galan

Volume 371

B. R. Cullen, Duke University Center for Virology, Durham, NC, USA (Ed)

Intrinsic ImmunityRecent research has focused attention on the importance of intrinsic antiviral immunity, i.e. im-munity mediated by factors that are constitutively expressed in many cells.

Features 7 Written by leading experts in the field 7 Pro-vides a better understanding of the co-evolution of viral pathogens and their hosts 7 Offers perspec-tives for the design of antiviral drugs

Contents The APOBEC3 Family of Retroelement Restric-tion Factors.- Inhibition of Retroviral Replication by Members of the TRIM Protein Family.- The Antiviral Activities of Tetherin.- Restriction of Retroviral Infection of Macrophages.- Rapid Adversarial Co-Evolution of Viruses and Cellular Restriction Factors.- RNA Interference-Mediated Intrinsic Antiviral Immunity in Plants.- RNA Interference-Mediated Intrinsic Antiviral Im-munity in Invertebrates.- Roles of MicroRNAs in the Life Cycles of Mammalian Viruses.- Interplay Between DNA Tumor Viruses and the Host DNA Damage Response.

Fields of interestImmunology; Virology; Microbial Genetics and Genomics



Due May 2013

2013. VII, 342 p. 23 illus., 22 in color. Hardcover7 * € (D) 149,79 | € (A) 153,99 | sFr 186,507 € 139,99 | £126.00ISBN 978-3-642-37764-8

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65

M. Czader, Indiana University, Indianapolis, IN, USA (Ed)

Hematological MalignanciesContents Quantitative BCR-ABL1 RQ-PCR Fusion Transcript Monitoring in Chronic Myelogenous Leukemia.- Detection of BCR-ABL1 Kinase Domain Mutations Causing Imatinib Resistance in Chronic Myelogenous Leukemia.- Laboratory Detection of JAK2V617F in Human Myeloprolif-erative Neoplasms.- c-kit Mutational Analysis in Paraffin Material.- Detection of Recurrent Cytoge-netic Abnormalities in Acute Lymphoblastic and Myeloid Leukemias using Fluorescence In Situ Hybridization.- Liquid Bead Array Technology in the Detection of Common Translocations in Acute andChronic Leukemias.- Molecular Genetic Tests for FLT3, NPM1, and CEBPA in Acute Myeloid Leukemia.- Flow Cytometric Monitoring of Residual Disease in Acute Leukemia.- Chime-rism Analysis Following Hematopoietic Stem Cell Transplantation.- Detection of Clonal Immuno-globulin Heavy Chain Gene Rearrangements by the Polymerase Chain Reaction and Capillary Gel Electrophoresis.- Detection of Clonal T-cell Re-ceptor Beta and Gamma Chain Gene Rearrange-ment by Polymerase Chain Reaction and Capillary Gel Electrophoresis.- Detection of Genetic Trans-locations in Lymphoma using Fluorescence in situ Hybridization.- Molecular Detection of t(14;18)(q32;q21) in Follicular Lymphoma.- Detection of t(11;14)(q13;q32) in Mantle Cell Lymphoma by Polymerase Chain Reaction.- Detection of t(2;5)(p23;q35) in Anaplastic Large Cell Lym-phoma by Long-range Nested Polymerase Chain Reaction Assay.- EBER In Situ Hybridization for Epstein-Barr Virus.-Epstein-Barr virus (EBV) Load Determination Using Real-time Quantitative Polymerase Chain Reaction. [...]

Fields of interestMolecular Medicine; Hematology



Due May 2013

2013. X, 304 p. 47 illus., 32 in color. (Methods in Molecular Biology, Volume 999) Hardcover7 * € (D) 101,64 | € (A) 104,49 | sFr 126,507 € 94,99 | £85.50ISBN 978-1-62703-356-5

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M. Divangahi (Ed)

The New Paradigm of Immunity to TuberculosisThis book illustrates the intimate relationship between alveolar macrophages and Mycobacte-rium tuberculosis (M.tb.), and the former’s role in both innate and adaptive immunity against M.tb. It covers research done over the last decade. It also explores the role of macrophage death following infection with M.tb. in determining whether suc-cessful immunity is stimulated, or whether clinical disease develops; furthermore, the function of host lipid mediators in macrophage death modal-ity are addressed. The book also illustrates how the balance between prostaglandins and lipoxins de-termines whether infected macrophages undergo apoptosis or necrosis, which is the ultimate factor in the outcome of infection. Finally, it is a synthe-sis of the authors’ recent studies and the studies of others to offer a new understanding of immunity to tuberculosis.

Features 7 Will offer a new understanding of immunity to tuberculosis 7 Explore a novel approach to designing a new tuberculosis vaccine 7 Cover the latest advances in tuberculosis research of the past decade

Fields of interestImmunology; Medical Microbiology; Antibodies



Available

2013. VI, 292 p. 20 illus., 17 in color. (Advances in Experimental Medicine and Biology, Volume 783) Hardcover7 * € (D) 149,75 | € (A) 153,94 | sFr 186,507 € 139,95 | £126.00ISBN 978-1-4614-6110-4

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A. A. Farooqui, Ohio State University, Columbus, OH, USA

Metabolic SyndromeAn Important Risk Factor for Stroke, Alzheimer Disease, and Depression

Features 7 Provides a comprehensive description of signal transduction processes associated with the rela-tionship between metabolic syndrome and neu-rological disorders 7 Useful for understanding molecular aspects of metabolic syndrome and its relationship with neurological disorders 7 Can be used as supplement text for a range of neurosci-ence and biochemistry courses

Contents Chapter 1:The effect of unhealthy lifestyle on brain metabolism and function.- Chapter 2: The effect of metabolic syndrome on the brain.- Chapter 3: The Association of essential fatty acid metabolism in the pathogenesis of metabolic syndrome and neurological disorders.- Chapter 4: Contribution of lipid mediators to the pathogenesis of metabolic syndrome and neurological disorders.- Chapter 5: Molecular aspects of obesity and insulin resis-tance in metabolic syndrome and neurological disorders.- Chapter 6: Dietary interventions of metabolic syndrome and neurological disorders.- Chapter 7: Signal transduction processes and metabolic link among metabolic syndrome and stroke.- Chapter 8: Signal transduction processes and metabolic link among metabolic syndrome and Alzheimer’s disease.- Chapter 9: Signal transduction processes and metabolic link among metabolic syndrome and depression.- Chapter 10: Future research perspectives .

Fields of interestNeurosciences; Neurology; Neurochemistry



Due June 2013

2013. XIV, 460 p. 86 illus., 46 in color. Hardcover7 * € (D) 160,49 | € (A) 164,99 | sFr 200,007 € 149,99 | £135.00ISBN 978-1-4614-7317-6

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66

C. G. Galizia, Universität Konstanz, Germany; P.-M. Lledo, Institut Pasteur, Paris, France (Eds)

Neurosciences - From Molecule to Behavior: a university textbookNeurosciences – a comprehensive approach This textbook covers neuroscience from cellular and molecular mechanisms to behavior and cognitive processing.

Features 7 A current compendium of neurosciences Experts from all over Europe 7 Modular de-sign 7 Covers the entire field of neurosciences from a zoological perspective 7 Newest state-of-the-art knowledge about neuroscience

Contents From Neurophysiology to Neuroscience: New echnologies and New Concepts in the Twentieth Century.- Evolution of Nervous Systems and Brains.- Ontogeny of the Vertebrate Nervous System.- Diseases.- Neurophilosophy.- Cellular and Molecular Basis of Neural Function.- Electri-cal Activity in Neurons.- The Synapse.- Biology and Function of Glial Cells.- The Autonomic Nervous System.- Neuropeptides and Peptide Hormones.- The Biological Function of Sensory Systems.- Olfaction.- Taste.- Thermosensation.- Mechanosensation.- Auditory Systems.- Vision.- Electroreception.- The Magnetic Senses.- Pain and Nociception.- Muscles and Motility.- Mo-tor Control.- The Neural Bases of Emotions.- Experience-Dependent Plasticity in the Central Nervous System.- Cellular Correlates of Learning and Memory.- Circadian Timing.- Learning, Memory, and Cognition: Animal Perspectives.- Primate Social Intelligence.- Computational Neuroscience:Capturing the Essence.

Fields of interestNeurosciences; Neurobiology

Target groupsUpper undergraduate

Product categoryUndergraduate textbook

Due May 2013

2013. XI, 786 p. 404 illus., 390 in color. Hardcover7 * € (D) 49,95 | € (A) 51,35 | sFr 62,507 € 46,68 | £42.99ISBN 978-3-642-10768-9

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S. Geyer, R. Turner, MPI for Human Cognitive and Brain Sciences, Leipzig, Germany (Eds)

Microstructural Parcellation of the Human Cerebral CortexFrom Brodmann’s Post-Mortem Map to in Vivo Mapping with High-Field Magnetic Resonance Imaging

Contents Guy N. Elston, Laurence J. Garey: The cyto-architectonic map of Korbinian Brodmann: Arealisation and circuit specialization.- Lazaros C. Triarhou: The cytoarchitectonic map of Constan-tin von Economo and Georg N. Koskinas.- Rudolf Nieuwenhuys: The myeloarchitectonic studies on the human cerebral cortex of the Vogt - Vogt school, and their significance for the interpreta-tion of functional neuroimaging data.- Bruce Fischl: Estimating the location of Brodmann Areas from cortical folding patterns using histology and ex vivo MRI.- Simon B. Eickhoff, Danilo Bzdok: Database-driven identification of functional modules in the cerebral cortex.- Robert Turner: Where matters: New approaches to brain analysis.- Robert Turner: MRI methods for in-vivo cortical parcellation.- Nicholas A. Bock, Afonso C. Silva: Visualizing myeloarchitecture in vivo with mag-netic resonance imaging in common marmosets (Callithrix jacchus).- Stefan Geyer: High-field magnetic resonance mapping of the border be-tween primary motor (area 4) and somatosensory (area 3a) cortex in ex-vivo and in-vivo human brains.

Fields of interestNeurosciences; Human Physiology; Neuroradiol-ogy



Due June 2013

2013. X, 240 p. 94 illus., 36 in color. Hardcover7 * € (D) 149,79 | € (A) 153,99 | sFr 186,507 € 139,99 | £126.00ISBN 978-3-642-37823-2

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E. Y. Gong, Johnson & Johnson Corporation, Beerse, Belgium (Ed)

Antiviral Methods and ProtocolsContents A Fluorescence-Based High Throughput Screen-ing Assay to Identify HIV-1 Inhibitors.- A Homogeneous Time-Resolved Fluorescence Assay to Identify Inhibitors of HIV-1 Fusion.- Identifica-tion of HIV-1 Reverse Transcriptase Inhibitors Using a Scintillation Proximity Assay.- Biochemi-cal Screening Assays to Identify HIV-1 Integrase Inhibitors.- HIV-1 Genotyping of the Protease-Reverse Transcriptase and Integrase Genes to Detect Mutations that Confer Anti-Retroviral Resistance.- In Vitro Kinetic Profiling of Hepatitis C Virus NS3 Protease Inhibitors by Progress Curve Analysis.- A Novel Hepatitis C Virus NS5B Polymerase Assay of De Novo Initiated RNA Synthesis Directed from a Heteropolymeric RNA Template.- Selecting and Characterizing Drug-Resistant Hepatitis C Virus Replicon.- A Cellular Replicon-Based Phenotyping Assay to Determine Susceptibility of Hepatitis C Virus Clinical Isolates to NS3/4A Protease Inhibitors.- Expression and Purification of Hepatitis C Virus Protease from Clinical Samples.- Surface Plasmon Resonance as a Tool to Select Potent Drug Candidates for Hepa-titis C Virus NS5B Polymerase.- Amplification and Sequencing of the Hepatitis C Virus NS3/4A Pro-tease and the NS5B Polymerase Regions for Ge-notypic Resistance Detection of Clinical Isolates of Subtypes 1a and 1b.- A Southern Blot Assay for Detection of Hepatitis B Virus Covalently Closed Circular DNA from Cell Cultures.- In Vitro Phenotyping of Recombinant Hepatitis B Virus Containing the Polymerase/Reverse Transcriptase Gene from Clinical Isolates.- Cell-Based Antiviral Assays for Screening and Profiling Inhibitors Against Dengue Virus. [...]

Fields of interestPharmacology/Toxicology; Virology



Due June 2013

2nd ed. 2013. XII, 468 p. 52 illus., 28 in color. (Methods in Molecular Biology, Volume 1030) Hardcover7 * € (D) 117,69 | € (A) 120,99 | sFr 146,507 € 109,99 | £99.00ISBN 978-1-62703-483-8

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67

R. G. Gourdie, Virginia Tech Carilion Research Institute, Roanoke, VA, USA; T. A. Myers, MCPHS University, Worcester, MA, USA (Eds)

Wound Regeneration and RepairMethods and Protocols

Contents An In Vivo Model System for Evaluation of the Host Response to Biomaterials.- Urothelial Cell Culture.- Cell Populated Collagen Lattices Contraction Model for the Investigation of Fibroblast Collagen Interactions.- A Tissue-engineered Corneal Wound Healing Model for the Characterization of Reepithelialization.- Adult Stem Cells in Small Animal Wound Healing Models.- Novel Animal Models for Tracking the Fate and Contributions of Bone Marrow Derived Cells in Diabetic Healing.- Cell-Based Therapies for Myocardial Repair: Emerging Role for Bone Marrow Derived Mesencymal Stem Cells (MSCs) in the Treatment of the Chronically Injured Heart.- A Model System for Primary Abdominal Closures.- Alternatives for Animal Wound Model Systems.- Novel Methods for the Investigation of Human Hypertrophic Scarring and other Dermal Fibrosis.- Study of the Human Chronic Wound Tissue: Addressing Logistic Barriers and Produc-tive use of Laser Capture Microdissection.- The Wound Watch: An Objective Staging System for Wounds in the Diabetic (db/db) Mouse Model.- Human Ex vivo Wound Healing Model.- Murine Models of Human Wound Healing.- A Corneal Scarring Model.- A Novel and Efficient Model of Coronary Artery Ligation in the Mouse.- Cardiac Wound Healing Post-Myocardial Infarction: A Novel Method to Target Extracellular Matrix Remodeling in the Left Ventricle. [...]

Fields of interestMolecular Medicine; Regenerative Medicine/Tis-sue Engineering



Due September 2013

2013. 590 p. 134 illus., 40 in color. (Methods in Molecular Biology, Volume 1037) Hardcover7 * € (D) 133,74 | € (A) 137,49 | sFr 166,507 € 124,99 | £112.50ISBN 978-1-62703-504-0

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D. M. Hatters, A. J. Hannan, University of Melbourne, Parkville, VIC, Australia (Eds)

Tandem Repeats in Genes, Proteins, and DiseaseMethods and Protocols

Contents Longitudinal Imaging and Analysis of Neurons Expressing Polyglutamine-Expanded Proteins.- Atomic Force Microscopy Assays for Evaluating Polyglutamine Aggregation in Solution and on Surfaces.- Morphometric Analysis of Huntington’s Disease Neurodegeneration in Drosophila.- Size Analysis of Polyglutamine Protein Aggregates using Fluorescence Detection in an Analytical Ultracentrifuge.- A Method for the Incremental Expansion of Polyglutamine Repeats in Recom-binant Proteins.- Pulse Shape Analysis (PulSA) to Track Protein Translocalization in Cells by Flow Cytometry: Applications for Polyglutamine Aggregation.- Characterizing Social Behavior in Genetically Targeted Mouse Models of Brain Disorders.- PCR Amplification and Sequence Analysis of GC-rich Sequences: Aristaless-Related Homeobox Example.- Challenges of “sticky” Co-Immunoprecipitation; Polyalanine Tract Protein-Protein Interactions.- Molecular Pathology of Polyalanine Expansion Disorders-new Perspec-tives from Mouse Models.- Yeast as a Platform to Explore Polyglutamine Toxicity and Aggrega-tion.- Immunobased Detection Assays to Quantify Distinct Mutant Huntingtin Conformations in Biological Samples.- Modeling and Analysis of Repeat RNA Toxicity in Drosophila.- Analyzing Modifiers of Protein Aggregation in C. elegans by Native Agarose Gel Electrophoresis.- Kinetic Analysis of Aggregation Data.- A Bioinformat-ics Method for Identifying Q/N-rich Prion-like Domains in Proteins. [...]

Fields of interestHuman Genetics; Gene Function



Due May 2013


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B. Henderson, University College London, UK (Ed)

Moonlighting Cell Stress Proteins in Microbial InfectionsContents Bacterial Cell Stress Responses.- A Brief Intro-duction to Eukaryotic Cell Stress Proteins.- New Thoughts on Protein Moonlighting.- Chaperonin 10 a Pro- and Anti-inflammatory Host Modula-tor.- Helicobacter pylori peptidyl prolyl cis, trans isomerase: a modulator of the host immune response.- Macrophage Infectivity Promoter: An FK506-Binding Peptidylprolyl Isomerase with Collagen-Binding and Transmigrating Activity.- Evolution of Bacterial Chaperonin 60 Paralogues and Moonlighting Activity.- Mycobacterium tuberculosis Chaperonins as Novel Virulence Factors.- Legionella pneumophila Chaperonin 60: A Multifunctional Virulence Protein.- Chapero-nin 60.1 of the Chlamydiae (cHSP60) as a Major Virulence Determinant.- Symbiotic Bacterial Chaperonin 60 and Plant Virus Transmission.- Histoplasma capsulatum Chaperonin 60: A Novel Adhesin and Vaccine Candidate.- The role of stress-induced activation of HSP70 in dendritic cells, CD4+ T cell memory and adjuvanticity.- Candida albicans Ssa: A Hsp70 Homologue and Virulence Factor.- Hsp90 plays a role in host-bac-terial interactions: Insight gained from Acantham-oeba castellanii.- Role of Peptidyl-Prolyl cis/trans Isomerases in Cellular Uptake of Bacterial Protein Toxins.- Listeria monocytogenes and Host Hsp60 - an Invasive Pairing.- Cell Surface Stress Proteins and the Receptor for Lipopolysaccharide.- Grp78 (BiP) a Cell Surface Receptor for Viruses.- BiP (Grp78): a Target for Escherichia coli Subtilase Cytotoxin.- Cholera Toxin Interactions with Host Cell Stress Proteins.- Endoplasmic reticulum stress-associated Gp96 chaperone is a host recep-tor for Adherent-Invasive E. coli. [...]

Fields of interestBiomedicine general; Protein Science; Microbiol-ogy



Due June 2013

2013. XIV, 437 p. 54 illus., 33 in color. (Heat Shock Proteins, Volume 7) Hardcover7 * € (D) 160,49 | € (A) 164,99 | sFr 200,007 € 149,99 | £135.00ISBN 978-94-007-6786-7

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68

F. Innocenti, University of North Carolina at Chapel Hill, NC, USA; R. H. Schaik, Erasmus MC University Medical Center, Rotterdam, The Netherlands (Eds)

PharmacogenomicsMethods and Protocols

Contents Pharmacogenomics: Historical Perspective and Current Status.- Denaturing High-Performance Liquid Chromatography for Mutation Detec-tion and Genotyping.- Clinical SNP Detection by the SmartAmp Method.- MALDI-TOF Mass Spectrometry.- TaqMan® Drug Metabolism Genotyping Assays for the Detection of Human Polymorphisms Involved in Drug Metabolism.- Pyrosequencing of Clinically Relevant Polymor-phisms.- Pharmacogenetics Using Luminex® xMAP® Technology: Method for Developing a Custom Multiplex Single Nucleotide Polymor-phism Mutation Assay.- Use of Linkage Analysis, Genome-Wide Association Studies, and Next-Generation Sequencing in the Identification of Disease-Causing Mutations.- The GoldenGate Ge-notyping Assay: Custom Design, Processing, and Data Analysis.- Genome-Wide Gene Expression Profiling, Genotyping, and Copy Number Analy-ses of Acute Myeloid Leukemia Using Affymetrix GeneChips.- Epigenetic Techniques in Pharma-cogenetics.- Plasmid Derived External Quality Controls for Genetic Testing.- Allelic Imbalance Assays to Quantify Allele-Specific Gene Expres-sion and Transcription Factor Binding.- SCAN: A Systems Biology Approach to Pharmacogenomic Discovery.- Methods to Examine the Impact of Nonsynonymous SNPs on Protein Degradation and Function of Human ABC Transporter.- In Vitro Identification of Cytochrome P450 Enzymes Responsible for Drug Metabolism.- In Vitro and In Vivo Mouse Models for Pharmacogenetic Stud-ies. [...]

Fields of interestPharmacology/Toxicology; Human Genetics



Due June 2013


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D. Jaeger, R. Jung (Eds)

Encyclopedia of Computational NeuroscienceThe annual Computational Neuroscience Meeting (CNS) began in 1990 as a small workshop called Analysis and Modeling of Neural Systems. The goal of the workshop was to explore the boundary between neuroscience and computation.

Fields of interestNeurosciences; Neurobiology; Computation by Abstract Devices


Product categoryEncyclop(a)edia

Due January 2014

Print

In 2 volumes, not available separately

2014. Approx. 3000 p. 1000 illus. 7 approx. * € (D) 1284,00 | € (A) 1320,00 | sFr 1597,507 approx. € 1200,00 | £1080.00ISBN 978-1-4614-6674-1

9<HTMERB=eggheb> eReference


2014. 7 approx. ** € (D) 1428,00 | € (A) 1440,00 | sFr 1679,007 approx. € 1200,00 | £1080.00ISBN 978-1-4614-6675-8

9<HTMERB=egghfi> Print + eReference


2014. Approx. 3000 p. 1000 illus. 7 approx. * € (D) 1605,00 | € (A) 1650,00 | sFr 1997,007 approx. € 1500,00 | £1350.00ISBN 978-1-4614-6676-5

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JIMD ReportsE. Morava, G. Brown (Eds), Managing editor: V. Peters, Editors-in-chief: J. Zschocke, K. M. Gibson

Volume 10

J. Zschocke, Medical University Innsbruck, Austria; K. M. Gibson, Michigan Technological University, Houghton, MI, USA; G. Brown, University of Oxford, UK; E. Morava, Radboud University Nijmegen, The Netherlands; V. Peters, Heidelberg University Hospital, Germany (Eds)

JIMD Reports - Volume 10JIMD Reports publishes case and short re-search reports in the area of inherited metabolic disorders. Case reports highlight some unusual or previously unrecorded feature relevant to the disorder, or serve as an important reminder of clinical or biochemical features of a Mendelian disorder.

Features 7 Unique collection of case and research reports on rare metabolic disorders 7 Contains unusual or previously unrecorded features relevant to metabolic disorders 7 All contributions rigor-ously peer-reviewed

Contents Different case studies.

Fields of interestHuman Genetics; Metabolic Diseases; Pediatrics



Due April 2013

2013. Approx. 120 p. Softcover7 * € (D) 106,99 | € (A) 109,99 | sFr 133,507 € 99,99 | £90.00ISBN 978-3-642-37333-6

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69

JIMD ReportsE. Morava, G. Brown (Eds), Managing editor: V. Peters, Editors-in-chief: J. Zschocke, K. M. Gibson

Volume 11

J. Zschocke, Medical University Innsbruck, Austria; K. M. Gibson, Michigan Technological University, Houghton, MI, USA; G. Brown, University of Oxford, UK; E. Morava, Radboud University Nijmegen, The Netherlands; V. Peters, Heidelberg University Hospital, Germany (Eds)

JIMD Reports - Volume 11JIMD Reports publishes case and short re-search reports in the area of inherited metabolic disorders. Case reports highlight some unusual or previously unrecorded feature relevant to the disorder, or serve as an important reminder of clinical or biochemical features of a Mendelian disorder.

Features 7 Unique collection of case and research reports on rare metabolic disorders 7 Contains unusual or previously unrecorded features relevant to metabolic disorders 7 All contributions rigor-ously peer-reviewed

Fields of interestHuman Genetics; Metabolic Diseases; Pediatrics



Due May 2013

2013. Approx. 120 p. Softcover7 approx. * € (D) 106,99 | € (A) 109,99 | sFr 133,507 approx. € 99,99 | £90.00ISBN 978-3-642-37327-5

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R. B. John, California State University, Northridge, USA

Brain Theory From A Circuits And Systems PerspectiveHow electrical science explains neuro-circuits, neuro-systems, and qubits

This book models an idealized neuron as be-ing driven by basic electrical elements, the goal being to systematically characterize the logical properties of neural pulses. In order to constitute a system, neurons as pulsating devices may be rep-resented using novel circuit elements as delineated in this book.

Features 7 Includes clear explanations of neural pulses with reference to physical circuitry 7 Easy exercises are provided at the ends of each chapter for serious readers who want to really understand the material being offered 7 Educationally valuable laboratory experiments in the form of simulations of neural properties are offered in an appendix 7 High level relevance to artificial intelligence and robotics

Contents Preface.- 1. Brain Structure.- 2. Brain Architecture For An Intelligent Stream Of Consciousness.- 3. Circuit Elements Required For Neural Systems.- 4. Long Term Memory, Simulated Qubits, Physical Qubits.- 5. Outline of a Cue Editor.- 6. Plans For A Recall Referee.- 7. Arithmetic Using Simulated Qubits.- 8. Long Term Memory Neural Circuits, Fast And Precise.- 9. Neuroquantology, The Ultimate Quest.- 10. The Phase Of The “1”.- Post Script.- Appendix 1.- Appendix 2.- Listing Of Sample WinSpice Code.

Fields of interestNeurosciences; Circuits and Systems; Cognitive Psychology



Due April 2013

2013. XVI, 229 p. 125 illus., 39 in color. (Springer Series in Cognitive and Neural Systems, Volume 6) Hardcover7 * € (D) 149,79 | € (A) 153,99 | sFr 186,507 € 139,99 | £126.00ISBN 978-1-4614-6411-2

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T. Jue, University of California Davis, California, US; K. Masuda, Kanazawa University, Kakuma-machi, Kanazawa-city, Ishikawa, Japan (Eds)

Application of Near Infrared Spectroscopy in BiomedicineIn keeping with the style of the Handbook of Modern Biophysics, this fourth volume, Applica-tion of Near-Infrared Spectroscopy in Biomedi-cine, balances the need for physical science/math-ematics formalism with a demand for biomedical perspectives. Each chapter divides the presenta-tion into two major parts: the first establishes the conceptual framework and describes the instru-mentation or technique, while the second illus-trates current applications in addressing complex biology questions. With the additional sections on further reading, problems, and references, the interested reader can explore some chapter ideas more widely.

Features 7 Fourth volume in the acclaimed series Hand-book of Modern Biophysics 7 Contributions by experts in the field Includes problem sets and additional references for further study

Contents Principles and Instrumentation.- Photon Migra-tion in Tissue.- Photon Migration in NIRS Brain Imaging.- Clinical Application of NIRS.- In-Vivo NIRS and Muscle Oxidative Metabolism.- Intra-cellular Oxygen Dynamics Observed by NIRS dur-ing Skeletal Muscle Contraction.- Muscle Oxygen Saturation Measurements in Diving Mammals and Birds Using NIRS.- Noninvasive NMR and NIRS Measurement of Vascular and Intracellular Oxygenation In Vivo.

Field of interestBiomedicine general

Target groupsGraduate


Available

2013. IX, 151 p. 72 illus., 23 in color. (Handbook of Modern Biophysics, Volume 4) Hardcover7 * € (D) 106,99 | € (A) 109,99 | sFr 133,507 € 99,99 | £90.00ISBN 978-1-4614-6251-4

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70

R. L. Kao, East Tennesse State University, Johnson City, TN, USA (Ed)

Cellular CardiomyoplastyMethods and Protocols

Features 7 Includes cutting-edge methods and proto-cols in the MiMB standard format 7 Provides step-by-step detail essential for reproducible results 7 Contains key notes and implementa-tion advice from the experts

Contents Cellular Cardiomyoplasty: Its Past, Present and Future.- Skeletal Muscle Stem Cells.- Bone Marrow Stem Cells.- Adipose Tissue Derived Mesenchymal Stem Cells: Isolation, Expansion and Characterization.- Cardiac Side Population Cells and Sca-1-positive Cells.- Two Step Protocol for Isolation and Culture of Cardiospheres.- Gen-eration of Human iPSCs From Human Peripheral Blood Mononuclear Cells using Non-Integrative Sendai Virus in Chemically Defined Conditions.- Identification of Stem Cells after Transplanta-tion.- Methods to Study the Proliferation and Differentiation of Cardiac Side Population (CSP) Cells.- Immune Responses After Mesenchymal Stem Cell Implantation.- Route of Delivery, Cell Retention and Efficiency of Polymeric Microcap-sules in Cellular Cardiomyoplasty.- Angiogenic Nanodelivery Systems for Myocardial Therapy.-Bio-Hybrid Tissue Engineering for Cellular Cardiomyoplasty: Future Directions.- Decellular-ized Whole Heart for Bioartificial Heart.- Clinical Trials of Cardiac Repair with Adult Bone Marrow-Derived Cells.- Clinical Study Using Adipose Derived Mesenchymal-like Stem Cells in Acute Myocardial Infarction and Heart Failure.

Fields of interestMolecular Medicine; Cardiology



Due September 2013

2013. 220 p. 47 illus., 27 in color. (Methods in Molecular Biology, Volume 1036) Hardcover7 * € (D) 101,64 | € (A) 104,49 | sFr 126,507 € 94,99 | £85.50ISBN 978-1-62703-510-1

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S. Kortagere (Ed)

In Silico Models for Drug DiscoveryInfectious diseases caused by viruses, parasites, bacteria, and fungi are the number one cause of death worldwide. Although new technologies have improved diagnosis of infectious diseases, the efficacy of all known current anti-infective agents is threatened by the spread of drug-resistant forms of the pathogens.


Contents Virtual Screening in Drug Design.- In Silico Sys-tems Biology Approaches for the Identification of Antimicrobial Targets.- Genome Comparisons as a Tool for Antimicrobial Target Discovery.- In Silico Models for Drug Resistance.- An In Silico Model for Interpreting Polypharmacological Relation-ships in Drug-Target Networks.- On Exploring Structure–Activity Relationships.- Molecular Dy-namics Simulations in Drug Design.- Databases and In Silico Tools for Vaccine Design.- In Silico Models for B-Cell Epitope Recognition and Sig-naling.- The Collaborative Drug Discovery (CDD) Database.- Recognition of Nontrivial Remote Homology Relationships Involving Proteins of He-licobacter pylori: Implications for Function Rec-ognition.- Identification of Novel Anthrax Toxin Countermeasures Using In Silico Methods.- Ra-tional Design of HIV-1 Entry Inhibitors.- Malarial Kinases: Novel Targets for In Silico Approaches to Drug Discovery.- Designing Novel Inhibitors of Trypanosoma brucei.- Computational Models for Tuberculosis Drug Discovery.

Fields of interestPharmacology/Toxicology; Medicinal Chemistry



Due April 2013


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R. M. Kostrzewa, Quillen College of Medicine, Johnson City, TN, USA (Ed)

Handbook of NeurotoxicityThe Handbook of Neurotoxicity is a reference source for identifying, characterizing, instruct-ing on use, and describing outcomes of neuro-toxin treatments – to understand mechanisms associated with toxin use; to project outcomes of neurotoxin treatments; to gauge neurotoxins as predictors of events leading to neurodegenerative disorders and as aids to rational use of neurotox-ins to model disease entities. Neuroprotection is approached in different manners including those 1) afforded by therapeutic agents – clinical and preclinical; or 2) by non-drug means, such as exercise.

Features 7 Major reference work 7 Contains detailed information on a wide number of topics 7 Fea-tures contributions from experts across the field

Field of interestNeurosciences


Product categoryHandbook

Due November 2013

Print

2014. 1200 p. 7 * € (D) 533,93 | € (A) 548,90 | sFr 664,507 € 499,00 | £449.50ISBN 978-1-4614-5835-7

9<HTMERB=efidfh> eReference

2014. 7 ** € (D) 593,81 | € (A) 598,80 | sFr 698,007 € 499,00 | £449.50ISBN 978-1-4614-5836-4

9<HTMERB=efidge> Print + eReference

2014. 1200 p. 7 * € (D) 667,68 | € (A) 686,40 | sFr 831,007 € 624,00 | £562.00ISBN 978-1-4614-7458-6

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71

S. Lacey, Emory University School of Medicine, Atlanta, GA, USA; R. Lawson, University of Liverpool, Liverpool, UK (Eds)

Multisensory ImageryIs a pear sweeter than a peach? Which of Mona Lisa’s hands is crossed over the other?

Features 7 Broken into 2 sections, dealing with theoretical and applied perspectives, respectively 7 Writ-ten by leading researchers in the field 7 Meant as a graduate text, but also very useful for upper undergraduates, or researchers coming from other disciplines

Contents Introduction.- Visual Mental Imagery.- Somes-thetic Mental Imagery.- Auditory Aspects of Audi-tory Imagery.- Modulation by Sensory Experience and Comparison to Auditory Mental Imagery.- Motor and Kinesthetic Imagery.- Mental Imagery and Blindness.- Representing 3D Space in Work-ing Memory: Spatial Images from Vision, Hearing, Touch, and Languag.- Crossmodal Mental Imag-ery.- Is Synesthesia a Form of Mental Imagery? .- Visual Imagery in Haptic Shape Perception.- Auditory Imagery Contains More Than Audition.- Visual and Motor Mental Imagery after Brain Damage.- Imagery Questionnaires: Vividness and Beyond.- Cognitive Neuroscience of Mental Imag-ery: Methods and Paradigms.- Individual Differ-ences in Object versus Spatial Imagery: From Neu-ral Correlates to Real-World Applications.- Motor and Visual Imagery in Sports.- Mental Imagery and Mental Practice Applications in Surgery: State of the Art and Future Directions.- Mental Imagery and Psychopathology: Examples of Post-Traumat-ic Stress Disorder and Bipolar Disorder.- Imagery and Cravings.- Clinical Applications of Motor Imagery in Rehabilitation.- Summary and Some Future Directions

Fields of interestNeurosciences; Neurology; Cognitive Psychology

Target groupsGraduate


Available


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S. LeGrice, National Cancer Institute, Frederick, MD, USA; M. Gotte, McGill University, Montreal, QC, Canada (Eds)

Human Immunodeficiency Virus Reverse TranscriptaseThe Reverse Transcriptase (RT) of Human Im-munodeficiency Virus Type 1 (HIV-1) arguably ranks amongst one of the most extensively studied retroviral enzymes. Heterologous expression and purification of HIV-1 RT in the early eighties, approval of the first nucleoside analogue RT in-hibitor (NRTI) in 1987, discovery of resistance to RT inhibitors, approval of the first non-nucleoside analogue RT inhibitor (NNRTI) in 1996 and the various crystal structures of RT with and without bound substrate(s) and/or inhibitors represent only a few of the important milestones that describe the a bench-to-bedside success in the continuing effort to combat HIV-1 infection and its consequences. Nucleoside and nonnucleoside RT inhibitors remain important components in frequently used drug regimens to treat the infec-tion. RT inhibitors also play important roles in re-cently validated strategies to prevent transmission of the virus. The relevance of HIV-1 RT as a drug target has simultaneously triggered interest in basic research studies aimed at providing a more detailed understanding of interactions between proteins, nucleic acids, and small molecule ligands in general terms. In light of the ever-growing knowledge on structure and function of HIV-1 RT, this enzyme serves as a valuable “model system” in efforts to develop novel experimental tools and to explain biochemical processes.

Feature 7 First comprehensive volume in nearly 20 years Editors have more than 30 years of experience Book will also address the future of Reverse Transcriptase

Fields of interestVirology; Infectious Diseases; Immunology



Due July 2013

2013. VIII, 390 p. 73 illus., 49 in color. Hardcover7 * € (D) 149,79 | € (A) 153,99 | sFr 186,507 € 139,99 | £126.00ISBN 978-1-4614-7290-2

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A. J. Macario, E. Conway de Macario, University of Maryland, Baltimore, MD, USA; F. Cappello, University of Palermo, Italy

The ChaperonopathiesDiseases with Defective Molecular Chaperones

This Brief provides a concise review of chap-eronopathies, i.e., diseases in which molecular chaperones play an etiologic-pathogenic role. Introductory chapters deal with the chaperoning system and chaperoning teams and networks, HSP-chaperone subpopulations, the locations and functions of chaperones, and chaperone genes in humans.

Features 7 A unique and comprehensive survey and description of diseases, the chaperonopathies, in which molecular chaperones are etiologic-pathogenic factors 7 An easy-to-grasp, well-illustrated with tables and figures, panoramic view of the state-of-the-art analysis of chaper-onopathies 7 Unveils new routes to diagnose chaperonopathies, establish prognosis, treat and manage patients properly, thereby showing the path for future research

Contents Overview and book plan.- Chaperones: General characteristics and classifications.- The chaper-onopathies: classification, mechanisms, structural features.- Structural and hereditary chaperonopa-thies: mutation.- Other genetic chaperonopa-thies.- Acquired chaperonopathies.- Other types of chaperonopathies.- Impact of chaperonopathies in protein homeostasis and beyond.- Extracellular chaperones.

Fields of interestBiomedicine general; Biochemistry, general; Protein Science


Product categoryBrief

Due April 2013

2013. XVI, 116 p. 26 illus., 23 in color. (SpringerBriefs in Biochemistry and Molecular Biology) Softcover7 approx. * € (D) 53,45 | € (A) 54,95 | sFr 66,507 approx. € 49,95 | £44.99ISBN 978-94-007-4666-4

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72

S. Marinesco, Université Claude Bernard Lyon 1, France; N. Dale, University of Warwick, Coventry, UK (Eds)

Microelectrode BiosensorsContents Microelectrode Designs for Oxidase-Based Bio-sensors.- Microelectrode Array Fabrication and Optimization for Selective Neurochemical Detec-tion.- The Advantage of Microelectrode Tech-nologies for Measurement in Delicate Biological Environments Such as Brain Tissue.- Hexacyano-ferrates as Mediators for Microelectrode Biosen-sors.- Enzyme Immobilization on Microelectrode Biosensors.- Characterization of Polymer–Enzyme Composite Biosensors for Brain Monitoring In Vivo.- Monitoring Extracellular Glutamate in the Brain by Microdialysis and Microsensors.- Sub-Second Measurements of Glutamate and Other Neurotransmitter Signaling Using Enzyme-Based Ceramic Microelectrode Arrays.- Regulation of Extracellular Concentrations of D-Serine in the Central Nervous System Revealed by D-Amino Acid Oxidase Microelectrode Biosensors.- Mea-surement of Purine Release with Microelectrode Biosensors.- Glucose and Lactate Monitoring Across the Rat Sleep-Wake Cycle.- Forebrain Cholinergic Systems and Cognition: New Insights Based on Rapid Detection of Choline Spikes Using Enzyme-Based Biosensors.- Carbon Nanotubes-Based Microelectrode (Bio)sensors.- Label-Free Affinity Biosensors Based on Electrochemical Impedance Spectroscopy.- Aptamer-Based Elec-trochemical Biosensors for the Detection of Small Molecules and Plasma Proteins.- Electrochemi-luminescent Biosensors: Neuroscience Applica-tions.- Molecularly Imprinted Polymers: Promis-ing Advanced Materials for In Vivo Sensing.

Fields of interestNeurosciences; Neurochemistry



Due April 2013

2013. XV, 387 p. 111 illus., 45 in color. (Neuromethods, Volume 80) Hardcover7 * € (D) 117,69 | € (A) 120,99 | sFr 146,507 € 109,99 | £99.00ISBN 978-1-62703-369-5

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P. Y. Maximov, R. E. McDaniel, V. C. Jordan, Georgetown University Medical Center, Washington, DC, USA

TamoxifenPioneering Medicine in Breast Cancer

Tamoxifen is a pioneering medicine for the treat-ment and prevention of breast cancer. It is the first drug targeted therapy in cancer to be successful. Tamoxifen targets the tumor estrogen receptor. The therapy is known to have saved the lives of millions of women over the past 40 years. This monograph, written by V.

Features 7 The story of Tamoxifen written first-hand by the "father of tamoxifen" 7 A personal journey through four decades of discovery that changed women’s health 7 Including an interview with the pioneer of the therapy

Contents Discovery and Pharmacology of Nonsteroidal Estrogens and Antiestrogens.- Tamoxifen Goes Forward Alone.- Metabolites of Tamoxifen as the Basis of Drug Development.- Adjuvant Therapy – The Breakthrough.- The Wisconsin Story in the 1980’s: Discovery of Target Site Specific Estrogen Action.- Carcinogenesis and Tamoxifen.- Che-moprevention: Cinderella waiting for the ball.- Tamoxifen and Raloxifene head to head: The STAR TRIAL.- Acquired resistance to Tamoxifen: back to the beginning.- The legacy of Tamoxifen.- Appendix: Four decades of discovery in breast cancer research and treatment – an interview with V. Craig Jordan by Marc Poirot.- Selected Awards that Recognize the Contribution of Tamoxifen and Raloxifene to Medicine.

Fields of interestCancer Research; Pharmacology/Toxicology; Oncology



Due May 2013

2013. X, 252 p. 41 illus., 30 in color. (Milestones in Drug Therapy) Hardcover7 * € (D) 149,79 | € (A) 153,99 | sFr 186,507 € 139,99 | £126.00ISBN 978-3-0348-0663-3

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J. Moll, Boehringer Ingelheim; R. Colombo, Nerviano Medical Sciences, Nerviano Italy (Eds)

Target Identification and Validation in Drug DiscoveryMethods and Protocols

Contents The Path to Oncology Drug Target Valida-tion – an Industry Perspective.- Identification of Aptamers as Specific Binders and Modulators of Cell-Surface Receptor Activity.- The Design and Structure-functional Properties of DNA-based Immunomodulatory Sequences.- siRNA Design Principles and Off-target Effects.- Western Blot Evaluation of siRNA Delivery by pH Responsive Peptides.- High Throughput RNAi Screening for the Identification of Novel Targets.- Integration of RNAi and Small Molecule Screens to Identify Targets for Drug Development.- CellProfiler and KNIME: Open Source Tools for High Content Screening.- PARP Inhibition as a Prototype for Synthetic Lethal Screens.- Structure-Based Target Druggability Assessment.- Validating Pharmaco-logical Disruption of Protein-protein Interactions by Acceptor Photobleaching FRET Imaging.- Sys-tematic Analysis of Complex Signal Transduction Pathways using Protein Fragment Complementa-tion Assays.- Reverse-Phase Protein Microarrays and Their Utility in Drug Development.- A Cell Culture System that Mimics Chronic Lympho-cytic Leukemia Cells Microenvironment for Drug Screening and Characterization.- 2-Dimensional vs. 3-Dimensional in vitro Tumor Migration and Invasion Assays.- Tumor Spheroid-based Migra-tion Assays for Evaluation of Therapeutic Agents.- The NeuroSphere Assay (NSA) Applied to Neural Stem Cells (NSCs) and Cancer Stem Cells (CSCs).-Genetically Engineered Animal Models for in vivo Target Identification and Validation in Oncology. [...]

Fields of interestPharmacology/Toxicology; Medicinal Chemistry



Available

2013. XV, 371 p. 62 illus., 19 in color. (Methods in Molecular Biology, Volume 986) Hardcover7 * € (D) 117,65 | € (A) 120,95 | sFr 146,507 € 109,95 | £99.00ISBN 978-1-62703-310-7

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73

P. Monagle (Ed)

HaemostasisMethods and Protocols


Contents The Coagulation System in Humans.- Platelet Physiology.- The Role of the Blood Vessel Wall.- Specimen Requirements for the Haemostasis Laboratory.- Principles of Haemostasis Tests.- Reference Ranges of Coagulation Tests.- Lupus Anticoagulant Testing.- Activated Partial Throm-boplastin Time (APTT).- Prothrombin Time (PT) and International Normalised Ratio (INR).- Thrombin Clotting Time (TCT).- Thrombin Gen-eration.- Activated Clotting Time (ACT).- Factor XII Assays.- Fibrinogen.- Platelet Counting.- Platelet Morphology Analysis.- Light Transmis-sion Aggregometry.- Platelet Flow Cytometry.- Anti-factor Xa assay (anti-Xa).- Reptilase Time (RT).- Protamine Titration.- Laboratory Methods for the Assay if Tissue Factor Pathway Inhibi-tor (TFPI) in Human Plasma.- Heparin Induced Thrombocytopenia (HIT).- Nijmegen-Bethesda Assay to Measure Factor VIII Inhibitors.- Kaolin Clotting Time.- The Dilute Russell Viper Venom Time (DRVVT).- Platelet Neutralisation Test.- Antithrombin.- Protein C.- Protein S.- Testing for Hyperhomocysteinemia in Subjects with a History of Thromboembolic Events Using HPLC Tech-nique.- Anticardiolipin Antibody and Anti-Beta 2 Glycoprotetin I Assays.- Testing for Apolipo-protein (a) Phenotype Using Isoelectric Focusing and Immunoblotting Technique.- D-Dimer and Fibrinogen/Fibrin Degradation Products.

Fields of interestMolecular Medicine; Hematology



Due April 2013

2013. XIII, 431 p. 37 illus., 19 in color. (Methods in Molecular Biology, Volume 992) Hardcover7 * € (D) 117,69 | € (A) 120,99 | sFr 146,507 € 109,99 | £99.00ISBN 978-1-62703-338-1

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K. Morgan, University of Nottingham, UK; M. M. Carrasquillo, Mayo Clinic College of Medicine, Jacksonville, FL, USA (Eds)

Genetic Variants in Alzheimer’s DiseaseAlzheimer’s Disease is the most common form of dementia. The disease is characterised by the loss of synapses and neurons in the cerebral cortex and certain subcortical regions. In the last three years, the genetics of Alzheimer’s Disease has made significant advances; in fact, one could argue more than in the previous two decades. This has re-sulted in the identification of nine new genes and perhaps more importantly the realization that new pathways could be involved in the pathogenesis of Alzheimer’s. These new pathways are now legiti-mate targets for therapeutic intervention, which can possibly lead to treatment or a possible cure.

Features 7 The aim of this book is to put all of the recent genetic data on these new genes into context 7 New genetics of Alzheimer’s dis-ease 7 Different genetic variants are discussed, as well as biomarkers and future possibilities

Contents The Genetics of Alzheimer’s disease: Introduction and Perspective for the Future.- Apolipoprotein E .- Clusterin.- PICALM.- Complement Component (3b/4b) Receptor 1(CR1).- Bridging Integra-tor 1 (BIN1).- ATP-binding cassette, sub-family A (ABC1), member 7 (ABCA7).- Membrane-spanning 4-domains subfamily A, MS4A cluster.- Sialic acid binding immunoglobulin-like lectin-3 (CD33).- Erythropoietin-producing human hepa-tocellular carcinoma (EphA1).- CD2-associated protein (CD2AP).- Other Genes Implicated in Alzheimer’s Disease.- The Future Role of Biomark-ers in Alzheimer’s Disease Diagnostics.- Index.

Fields of interestHuman Genetics; Neurosciences; Gene Function



Due June 2013

2013. VIII, 264 p. 54 illus., 51 in color. Hardcover7 * € (D) 149,79 | € (A) 153,99 | sFr 186,507 € 139,99 | £126.00ISBN 978-1-4614-7308-4

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T. Palomo, Fundación Cerebro y Mente, Madrid, Spain; R. M. Kostrzewa, East Tennessee State University, Johnson City, TN, USA; R. J. Beninger, Queen’s University, Kingston, ON, Canada (Eds)

Staging Neuropsychiatric DisordersImplications for Etiopathogenesis and Treatment

Features 7 Contributors are all participants at a pres-tigious conference on neuropsychiatric disor-ders 7 This book is a resource for physicians and neuroscientists alike 7 Highlights different prevention and treatment strategies at different stages of disease progression

Contents Clinical Staging in the Pathophysiology of Psychotic and Affective Disorders: Facilitation of Prognosis and Treatment.- Staging Perspectives in Neurodevelopmental Aspects of Neuropsychiatry: Agents, Phases and Ages at Expression.- Epi-genetics and Biomarkers in the Staging of Neuro-psychiatric Disorders.- Staging Neurodegenerative Disorders: Structural, Regional, Biomarker, and Functional Progressions.

Fields of interestNeurosciences; Human Physiology; Neurobiology



Due May 2013

Only available in print

2013. VI, 394 p. 70 illus., 34 in color. Hardcover7 * € (D) 160,49 | € (A) 164,99 | sFr 200,007 € 149,99 | £135.00ISBN 978-1-4614-7263-6

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74

S. Patole, University of Western Australia, Perth, WA, Australia (Ed)

Nutrition for the Preterm NeonateA Clinical Perspective

Survival of extremely premature neonates has improved significantly following the advances in neonatal intensive care. Extrauterine growth restriction is a serious issue in this population. Nutritional exposures during critical period of life influence the individual’s risk of disease through-out life. Nutritional deficit and poor growth are associated with long term neurodevelopmental impairment, short stature and metabolic disorders in extremely preterm neonates. Optimising nutri-tion in the early postnatal life of the preterm neo-nate is therefore a priority. However this is easier said than done considering the frequency of feed intolerance, fear of necrotising enterocolitis, and the hesitancy in adopting an aggressive approach to parenteral nutrition in this population.

Features 7 This is a comprehensive book for understand-ing A to Z of nutrition for the preterm infant 7 It is the first book that provides clinical perspective with up-to-date evidence in all areas of pre-term nutrition 7 There is no other book that combines applied science and clinical aspects of preterm nutrition in such comprehensive manner

Contents Developmental physiology of the GIT and feed intolerance.- Enteral nutrition.- Parenteral nutri-tion.- Catch up growth / Developmental origin of adult diseases.- Monitoring growth and develop-ment.- Breast milk, breast feeding, and donor milk banks.- Nutrition in specific conditions.

Fields of interestBiomedicine general; Life Sciences, general; Medi-cine/Public Health, general



Due September 2013

1st ed. 2014. XX, 380 p. 7 illus., 4 in color. Hardcover7 * € (D) 160,49 | € (A) 164,99 | sFr 200,007 € 149,99 | £135.00ISBN 978-94-007-6811-6

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A. Prokop, Vanderbilt University, Nashville, TN, USA; B. Csukás, Kaposvár University, Kaposvár Somogy, Hungary (Eds)

Systems BiologyIntegrative Biology and Simulation Tools

Contents Functional genomics, proteomics, metabolomics and bioinformatics for systems biology.- Compar-ing biological networks: a survey on graph clas-sifying techniques.- Emergent properties of gene regulatory networks – models and data.- Regula-tory crosstalk analysis of biochemical networks in the nucleus accumbens.- Properties of biological networks.- Network analysis for systems biol-ogy.- Computational approaches for reconstruc-tion of time-varying biological networks from Omics data.- Probabilistic graphical modeling in systems biology: a framework for integrative ap-proaches.- Innovations of the rule-based modeling approach.- Reproducibility of model-based results in systems biology.- Parameter identifiability and redundancy, with applications to a general class of stochastic carcinogenesis models.- Semantic systems biology: formal knowledge representation in systems biology for model construction, re-trieval, validation and discovery.- Computational infrastructures for data and knowledge manage-ment in systems biology.- Computational tools and resources for integrative modeling in systems biology.- Agent-based modeling approaches to multi-scale systems biology: An example agent-based model of acute pulmonary inflam-mation.- Reconstructing cellular signaling and regulatory networks - an integrative approach for systems-level drug discovery.- A survey of current integrative network algorithms for systems biol-ogy.- Direct Computer Mapping based modeling of a multiscale process, involving p53/miR-34a signaling.

Fields of interestBiomedicine general; Microbial Genetics and Genomics; Simulation and Modeling



Due June 2013

2013. XXV, 655 p. 105 illus., 53 in color. Hardcover7 * € (D) 160,49 | € (A) 164,99 | sFr 200,007 € 149,99 | £135.00ISBN 978-94-007-6802-4

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F.-X. Reichl, M. Schwenk (Eds)

Regulatory ToxicologyContents Foreword.- Introduction.- Operation mode of regulatory toxicology.- Aims and institutions.- Aims and mission.- Application areas.- National and international collaboration.- Procedures and standards.- The regulatory process.- Quality assur-ance in regulatory toxcicology.- Toxicological risk assessment.- Methodological repertoire.- Toxico-logical tests.- Characterization of physicochemical parameters. [...]

Fields of interestPharmacology/Toxicology; Occupational Medi-cine/Industrial Medicine; Biomedicine general


Product categoryHandbook

Due October 2013

Print

Title of the original German edition: Regulatorische Toxikologie

2014. 1000 p. 360 illus., 180 in color. 7 * € (D) 533,93 | € (A) 548,90 | sFr 664,507 € 499,00 | £449.50ISBN 978-3-642-35373-4

9<HTOGPC=dfdhde> eReference


2014.7 ** € (D) 593,81 | € (A) 598,80 | sFr 698,007 € 499,00 | £449.50ISBN 978-3-642-35374-1

9<HTOGPC=dfdheb> Print + eReference


2014. 1000 p. 360 illus., 180 in color. 7 * € (D) 667,68 | € (A) 686,40 | sFr 831,007 € 624,00 | £562.00ISBN 978-3-642-35375-8

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75

A. Reichle, University Hospital Regensburg, Germany (Ed)

Evolution-adjusted Tumor Pathophysiology:The Novel Language of Tumor Biology

Contents Preface.-I Introduction.-Communication ─ evolu-tion ─ pathophysiology: An endogenous conjunc-tion ─Instead of an introduction.-II Combined modularized therapies for metastatic tumors: Pointing to central problems of communication among ‘systems participators’ in tumors.- Applied systems biology for the control of metastatic can-cer: Therapeutic top-down strategy for targeting the tumors’ normativity.- Targeting the proan-giogenic network in angiosarcomas: Biomodula-tory therapy.- Long-term results of combined modularized, immune-modulatory, angiostatic, and antiinflammatory therapy in systemically pre-treated multi-systems Langerhans cell histio-cytosis.- Redirecting and modulating rationaliza-tions of tumor-immanent normative functions in castration-resistant prostate ancer.-III Social engineering: Biomodulation, either endogenously initiated or by implementation of non-normative boundary conditions.- Non-hierarchically organized operations in malignancies: Stromal dysfunction induces hematopoetic malignan-cies.- Biomodulatory therapy approaches in renal clear cell carcinoma: A perspective.- Proteome analysis identified the PPARc ligand 15d-PGJ2 as a novel drug inhibiting melanoma progression and interfering with tumor-stroma interaction.IV The tumors’ normativity: Reconstructing and operationalizing starting points for an evolution theory.- The philosophical quest of a cancer cell: Redefining existentialism. [...]

Fields of interestCancer Research; Biomedicine general; Systems Biology



Due July 2013

2013. XV, 335 p. 95 illus., 87 in color. Hardcover7 * € (D) 160,49 | € (A) 164,99 | sFr 200,007 € 149,99 | £135.00ISBN 978-94-007-6865-9

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F. M. Ruggeri, I. Di Bartolo, Istituto Superiore di Sanità, Rome, Italy; F. Ostanello, M. Trevisani, University of Bologna, Italy

Hepatitis E VirusAn Emerging Zoonotic and Foodborne Pathogen

Hepatitis E (HEV) is a viral infectious disease that infects humans and domestic, wild, and synan-thropic animals alike. In developing countries, the disease often presents as an epidemic, transmitted primarily through the fecal-oral route. In recent years, sporadic cases have also been documented in industrial countries, including Europe. The identification and characterization of animal strains of HEV from pigs, wild boar, and deer, and the demonstrated ability of cross-species infec-tion by these animal strains raise potential public health concerns for foodborne and zoonotic transmission of the virus. This Brief will provide a thorough overview of HEV. It will discuss the epidemiology and pathogenesis of the virus in both humans and animals, review detection methods, and provide methods for its control and prevention.

Contents Introduction.- Etiology.- Epidemiology of the Hu-man HEV Infection.- Pathogenesis in Humans.- Epidemiology of the HEV Infection in Animals.- Pathogenesis in Swine.- Diagnosis of the Hepatitis E Infection.- Hepatitis E Virus: Food-related Issues.- Conclusions.- References .

Fields of interestVirology; Food Science; Infectious Diseases


Product categoryBrief

Due June 2013

2013. VI, 123 p. 8 illus. in color. (SpringerBriefs in Food, Health, and Nutrition) Softcover7 * € (D) 53,49 | € (A) 54,99 | sFr 67,007 € 49,99 | £44.99ISBN 978-1-4614-7521-7

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L. Santambrogio (Ed)

Immunology of the Lymphatic SystemThis book will be a comprehensive study of the lymphatic system and its immunological role. It will begin with lymphatic capillaries, their origin and development. It will treat lymph circulation, in general, with a special emphasis on lymph cir-culation in parenchymal organs. The next section will address lymph nodes, subcortical circulation and the conduit system. It will discuss organs with no lymphatic system, such as the brain. Finally, it will cover lymph composition and cells in the lymph. While primarily basic research, the volume will touch upon elements of the clinical, as well, broadening its scope and appeal.

Feature 7 Will provide an overview of the lymphatic system Will detail the role of the lymphatic system in immunology Will explore the lymphatic system, relative to specific organs

Contents Lymphatic Capillaries: Origin and Develop-ment.- Lymph Circulation.- Lymph Circulation in Parenchymal Organs.- Lymph in the LymphNodes Subcortical Circulation and the Conduit System.- Lymph in the Thymus.- Organs with No Lymphat-ic System (The Brain).- Lymph Composition (The Omics).- Cells in the Lymph.

Fields of interestImmunology; Medical Microbiology; Human Physiology



Due April 2013


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76

J. Tian, Chinese Academy of Sciences, Beijing, China (Ed)

Molecular ImagingFundamentals and Applications

Features 7 Covers a wide range of new theory, new techniques and new applications 7 Contributed by many experts in China 7 The editor has obtained the National Science and Technology Progress Award twice

Contents Part I: Molecular Imaging Theory and System.- Introduction.- Molecular Optical Simulation Environment.- Diffuse Optical Tomography.- Fluorescence Molecular Tomography.- Biolu-minescence Tomography.- Positron Emission Tomography.- Radioisotope Labeled Molecular Imaging in SPECT.- MRI Facility-Based Molecular Imaging.- Other Molecular Imaging Technol-ogy.- Optical Multi-Modality Molecular Imaging.- Medical Image Processing and Analysis.- Part II: Molecular Probes.- Opportunities and Challenges of Radiolabeled Molecular Probes.- Oligonucle-otide Probes.- Quantum Dots for Biological Imag-ing.- RGD-Based Molecular Probes for Integrin αvβ3 Imaging.- Part III: Applications of Molecular Imaging.- Basics of Molecular Biology.- Molecu-lar Imaging Techniques in Clinical Practice of Tumors.- Using Molecular Imaging Techniques to Study Protein-Protein Interactions.- Application of Molecular Imaging in Transgenic Animals.- Molecular Imaging Methods in Diabetes-Related Studies.

Fields of interestMolecular Medicine; Imaging / Radiology; Image Processing and Computer Vision



Available

Jointly published with Zhejiang University Press

Distribution rights in China: Zhejiang University Press

2013. Approx. 715 p. 300 illus. (Advanced Topics in Science and Technology in China) Hardcover7 * € (D) 213,99 | € (A) 219,99 | sFr 266,507 € 199,99 | £180.00ISBN 978-3-642-34302-5

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C. C. Tseng, X. Yang, Purdue University Calumet, Hammond, IN, USA

Learning Basic Genetics with Interactive Computer ProgramsTraditionally, genetics laboratory exercises at the university level focus on mono- and dihy-brid crosses and phenotypic analysis—exercises under traditional time, materials, and process constraints. Lately, molecular techniques such as gene cloning, polymerase chain reactions (PCR), and bioinformatics are being included in many teaching laboratories—where affordable. Human chromosome analysis, when present at all, has often been restricted to simple identifica-tion of chromosomes by number, through the usual “cut-and-paste” method. Although several online karyotyping (chromosome identifica-tion) programs have become available, they are not meaningful for studying the dynamics of the chromosome system, nor do they help students understand genetics as a discipline.

Features 7 Includes a comprehensive and interactive learning program focused on chromosome simulation and model building 7 Intends to help students and their teachers learn more about genetics with greater ease and less anxiety 7 The karyotyping program used with this book was by the clinical genetics lab at the University of Chicago and Purdue University Calumet

Contents Computer modeling of chromosomes: A new approach for genetics education.- Chromosome techniques.- Chromosome models for learning genetic principles.- Chromosomes and genom-ics.- Chromosome identification.- Chromosome abnormalities and diseases.

Fields of interestHuman Genetics; Computational Biology/Bioin-formatics; Cytogenetics


Product categoryUndergraduate textbook

Due June 2013

2013. IX, 261 p. 400 illus., 388 in color. With online files/update. Hardcover7 * € (D) 64,15 | € (A) 65,95 | sFr 80,007 € 59,95 | £53.99ISBN 978-1-4614-6082-4

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W. D. Wick, O. O. Yang

War in the BodyThe Evolutionary Race Between HIV and the Human Immune System and the Implications for Vaccines

In the relatively few decades since the introduc-tion of HIV into the human population, variants of the virus have diverged to such an extent that, were the discussion about something other than viruses, said variants could easily be classified as different species.

Features 7 Explores the rapid and profound evolution of the HIV virus 7 Considers the divergent view-points on why and how the virus evolves 7 Ad-dresses the ramifications of this evolution on the immune system, as well as vaccines

Contents The HIV Infection model.- The CTL Model.- Simulating an HIV Infection In Vivo.- The Escape Formula.- Early and Late Escapes.- Understanding Escape.- More Topics about Escape from Immune Control.- HIV’s Cloaking Device: The Fascinating Story of Nef.- Retroviral Sex and Escape.- The Ne Business, Again, and a Proposed Experiment.- Can a T-cell Vaccine Block Escape?.- The STEP Trial and the Future of T-cell Vaccines.- Short Tutorial on Dynamical Models.- Deterministic Modeling: A Cautionary Example.- The Infection Model Defined.- The CTL Model Defined.- On Simulation Techniques.- Derivation of the Escape Formula.- Statistics of the Mutant Lineage in Classical Genetics.- Extinction Probabilities with Extra_Poisson Variation.- Computing the Boundaries.- Co-existence or Replacement?.- The Nef-Deletion Threshold Formulas.- Modeling Retroviral Sex.

Fields of interestVirology; Immunology; Vaccine



Due June 2013

2013. XX, 340 p. 51 illus., 4 in color. Hardcover7 * € (D) 266,43 | € (A) 273,90 | sFr 331,507 € 249,00 | £224.50ISBN 978-1-4614-7293-3

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77

H. Willard, S. Haga, Duke University, Durham, NC, USA

The Book of Genes & GenomesThe Book of Genes &Genomes presents a concise overview of the advances in genetics and genomics and provide the unfamiliar reader with a suc-cinct description of many of the applications and implications of this field. Given the substantial investment in genetics and genomics over the past several decades and the many recent discoveries and developments, this book will help the reader begin to understand the importance of genetics and genomics to us all. This exciting new title includes information on how genetics and genom-ics has advanced our understanding of health and medicine, evolution, and biology, as well as how they are pushing the boundaries of ethics and social values.

Features 7 Assumes no prior knowledge on the part of the reader. 7 Easy to understand writing style, enabling novices to read and speak the "language" of genes and genomes. 7 Inclusion of case-studies that depict how genes and genomics have advanced understanding of health, medicine, evolution and biology, but juxtaposed to ethics and social values 7 Recommended reading of-fered to facilitate self study. 7 Clear, up to date and affordable

Contents Preface.- Genomes is to Genomics as Genes is to Genetics.- Genetics and Genomics Applications.- A Brave New World of Genes and Genomes: Implications of Innovation

Fields of interestHuman Genetics; Biomedicine general


Product categoryPopular science

Due August 2013

2013. 400 p. Hardcover7 approx. * € (D) 20,60 | € (A) 21,18 | sFr 41,507 approx. € 19,25 | £19.99ISBN 978-0-387-70915-4

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L.-J. C. Wong, Baylor College of Medicine, Houston, TX, USA (Ed)

Next Generation SequencingTranslation to Clinical Diagnostics

Contents Part I: Overview.- History of DNA Sequencing Technologies.- Clinical Molecular Diagnostic Techniques: A Brief Review.- Part II: The Tech-nologies and Bioinformatics.- Methods of Gene Enrichment and Massively Parallel Sequencing Technologies.- Sequence Alignment, Analysis, and Bioinformatics Pipelines.- Protein Struc-tural Based Analysis for Variant Interpretation of Missense Variants at the Genomics Era: Using MNGIE Disease as an Example.- Algorithms and Guidelines for Interpretation of DNA Variants.- Part III: Application to Clinical Diagnostics.- NGS-based Clinical Diagnosis of Genetically Heterogeneous Disorders.- Molecular Diagnosis of Congenital Disorders of Glycosylation (CDG).- NGS Improves the Diagnosis of X-Linked Intellectual Disability (XLID).- NGS Analysis of Heterogeneous Retinitis Pigmentosa.- Next Generation Sequencing of the Whole Mitochon-drial Genome.- Application of Next-Generation Sequencing of Nuclear Genes for Mitochondrial Disorders.- Noninvasive Prenatal Diagnosis Using Next Generation Sequencing.- Part IV: Compli-ance with CAP/CLIA Regulations.- Guidelines and Approaches to Compliance with Regulatory and Clinical Standards: Quality Control Proce-dures and Quality Assurance.- Validation of NGS-based Test and Implementation of Quality Control Procedures.- Frequently Asked Questions about the Clinical Utility of Next Generation Sequenc-ing in Molecular Diagnosis of Human Genetic Diseases.- Index.

Fields of interestHuman Genetics; Bioinformatics; Biomedicine general



Due June 2013

2013. VI, 428 p. 33 illus., 27 in color. Hardcover7 * € (D) 160,49 | € (A) 164,99 | sFr 200,007 € 149,99 | £135.00ISBN 978-1-4614-7000-7

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A. A. Zachary, M. S. Leffell, The Johns Hopkins University, Baltimore, MD, USA (Eds)

Transplantation ImmunologyMethods and Protocols

Contents Alloreactivity.- Antibodies in Transplantation: The Effects of HLA and Non-HLA Antibody Bind-ing and Mechanisms of Injury.- Cell Mediated Rejection.- Transplantation Tolerance.- Composite Tissue Transplantation.- Transplantation of the Sensitized Patient: Histocompatibility Testing.- Thoracic Organ Transplantation: Laboratory Methods.- HLA Typing by Sequence Specific Primers.- Human Leukocyte Antigen (HLA) Typing By DNA Sequencing.- Next-Generation HLA Sequencing using the 454 GS FLX Sys-tem.- Chimerism Testing by Quantitative PCR Using Indel Markers.- Gene-specific PCR Typing of Killer Cell Immunoglobulin-like Receptors (KIR).- Complement-dependent Cytotoxicity Crossmatch.- Lymphocyte Crossmatching by Flow Cytometry.- Solid Phase Assay Measuring C4d Deposition to Determine Complement Fixation by HLA Specific Antibodies.- C1q Assay for the Detection of Complement Fixing Antibody to HLA Antigens.- Tetramer Staining for the Detec-tion of HLA-specific B cells.- A Flow Cytometric Crossmatch Test Using Endothelial Precursor Cells Isolated from Peripheral Blood.- Detection of Antibodies to Self-antigens (K-alpha 1 Tubulin, Collagen I, II, IV and V Myosin and Vimentin) by Enzyme-Linked Immunosorbent Assay (ELISA).- Cylex ImmuKnow Cell Function Assay.- Detec-tion of Intracellular Cytokines.- Tolerogenic Den-dritic Cells and Induction of T Suppresson Cells in Transplant Recipients.- Discovery and Customized Validation of Antibody Targets by Protein Ar-rays and Indirect ELISA.- RNA Purification and Expression Analysis using Microarrays and RNA Deep Sequencing.

Fields of interestImmunology; Transplant Surgery



Due June 2013


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A. Aghamohammadi, N. Rezaei, Mouse Models of Allergic Mouse … · 2013-05-07 · A. Aghamohammadi, N. Rezaei, Tehran University of Medical Sciences, Iran (Eds) Clinical Cases in

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