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12.1 and 12.2 DNA and DNA Replication - OAK PARK USD ... 12.1 and 12.2 DNA and DNA Replication DNA & DNA Replication Nucleotides ·monomers of DNA ·3 parts 5-carbon sugar...

Jan 25, 2021

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  • 12.1 and 12.2 DNA and DNA Replication

    DNA & DNA Replication

    Nucleotides · monomers of DNA · 3 parts

    5-carbon sugar phosphate group nitrogen base

    · 4 kinds pyrimidines - cytosine (C), thymine (T) purines - guanine (G), adenine (A)

    · complementary base pairing · C = G and G = C · A = T and T = A · base pairs are connected by hydrogen bonds (H-bonds)

    Chargaff's Rule 1 According to Chargaff's Rule, adenine

    (A) always binds with...

    A cytosine (C)

    B thymine (T)

    C guanine (G)

    D adenine (A)

    2 MATA: What are the 3 parts of a nucleotide?

    A 5-carbon sugar

    B hydrogen bond

    C nitrogen base

    D phosphate group

    E sulfur group

    X-ray evidence · Rosalind Franklin

    X-ray diffraction · her work showed DNA was...

    double stranded nitrogen bases on the inside twisted

    · initially given no credit for her work

    Click for video on Rosalind

    Photo 51

  • 12.1 and 12.2 DNA and DNA Replication

    structure of DNA · Watson and Crick's model - double helix · complementary base pairs

    A - T and C - G · base pairs connected by H-bonds · chains of nucleotides

    1 molecule of DNA contains millions of nucleotides · "sugar phosphate backbone"

    outside of DNA made of up sugars and phosphates

    3 MATA: Which of the following describe the structure of DNA?

    A single helix

    B C - G

    C hydrogen bonds

    D bases on the outside

    E sugar-phosphate backbone

    · making an exact copy of DNA · occurs during the S phase of Interphase · base pairing makes it possible · occurs from 3' end to 5' end · controlled by enzymes · semi-conservative - DNA molecules consist of 1 old and 1 new strand

    Replication Steps of Replication 1. helicase (enzyme) "unzips" a molecule of DNA 2. each strand serves as a template for the attachment of complementary bases 3. DNA polymerase (enzyme) constructs new DNA strand and "proofreads"

    Click for replication animation

    A A T T C C G G A T C G

    T T A A G G C C T A G C helicase

    DNA polymerase

    DNA polymerase

    PullPull

  • 12.1 and 12.2 DNA and DNA Replication

    4 What enzyme is responsible for unzipping DNA?

    A DNA polymerase

    B DNA transcriptase

    C RNA polymerase

    D helicase

    Replication Practice 1. CCC GGG TTT AAA GCC ATA

    2. TTG CAA GGC ATT CTG GAT

    3. AGC CAG TTC GAG TCA CAT

    5 Replicate the following strand of DNA. ATA CGA GAT TCC CTG

    A ATA CGA GAT TCC CTG

    B TAT CGA CTA TCC GAC

    C TAT GCT CTA AGG GAC

    D TAT GCT GTA AGG CAC

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