(1) MLTHSC 1042 (Introduction to Immunology)

8/3/2019 (1) MLTHSC 1042 (Introduction to Immunology)

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IMMUNOLOGI(MLTHSC1042)Nilaian : 2 Jam kredit

Penilaian berterusan : 40%(Mid sem & Assigment)

Peperiksaan akhir : 60%

Oleh:

Wan Norfaisal Amri b. Wan Noridan

(Bsc. (Hons.) Biomedical Science UKM)

Tel: 013-3452970

Lecturer

Medical Lab Technology Department

Science and Technology Islamic College


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INTRO. CELL&ORGAN HOW DISEASE TEST

1. Definition

2. Importanc

e

3. Immunity

type

4. Immunitycharacteris

tic)

Cell1.Agranulocytes

Lymfphocytes

Monocytes

2. Granulocytes Neutrophile

Basophile

Eosinophile

3. Dendritic cell

4. Mast cell

5. Others

Organ

1. Limfoid

primer

Bone

marrow

Thymus

2.Limfoid

sekunder

Lymphatic

Vessel

Lymph

Nodes

1. Antigen

2. Antibody

3. Agglutination

4. Non-specific

immunologic

reaction

First barrier

Scnd barrier

5. Specific

immunologic

reaction

Third barrier

6. Cytokines

1. Hipersen

sitiviti

2. HLA

3. Immunol

ogical

disorder

1. Immun

oesei

2. Immun

openda

flour


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REFERENCE BOOKS

1. A SHORT COURCE IMMUNOLOGY FIFTHEDITION

Author: Richard coico, Geoffrey sunshine, ElBenjamin

2. A SHORT COURCE IMMUNOLOGY SECONDEDITION

Author: Eli Benjamin and friends

3. Others


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PENGENALAN

DEFINISI

KEPENTINGAN

JENIS

CIRI-CIRI

Objektif pembelajaran:1. Memahami definisi

immunologi dari segi

bahasa dan istilah

2. Mengetahui kepentingan

sistem imun

3. Mengetahuijenis-jenis

sistem imun dalam manusia

beserta ciri2 umumnya


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DEFINISI

Immunologi

Immun-pertahanan badanlogi- Pengetahuan/Ilmu/

Definisi:

Bagaimana sistem badan melindungi badandaripada patogen dan bahan-bahan yangmerbahaya


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KEPENTINGAN SISTEM IMUN

Melindungi badan daripada bahan-bahan yang

merbahaya (virus, bakteria, fungi, patogen, parasitdll)

Memusnahkan sel yang tidak normal dalam

badan (sel kanser)

Mencegah daripada berlakunya pemusnahan sel

sendiri (Autoimmune disease)


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Kepentingan pada masa akan datang..

Gabungan bidang immunologi, genetik danbioteknologi menyumbang kpd pemahaman

tentang:-

Jangkitan

Kanser yg melibatka sum-sum tulang dan seldarah

Reaksi allergik

Penyakit autoimmune

Penyakit kekurangan sel2 dlm sistem imun

Penyakit berkaitan dengan immunosuppresion


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JENIS

1) INNATE IMMUNITY

2) ACQUIRED IMMUNITY


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CIRI-CIRI UMUM

1. Tidak spesifik pada antigen tertentu

2. Respon segera dan cepat (minit)

3. Tiada memori

4. Komponen imuniti:

Pertahanan semulajadi (e.g.kulit)

Sel Fagosit

Bahan larut (protein komplemen)

NATURAL IMMUNITY (semulajadi)


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1. Spesifik terhadap antigen tertentu

2. Respon yang lambat(beberapa hari)3. Mempunyai memori

4. Komponen immuniti:

Limfosit Antibody

ACQUIRED IMMUNITY (perolehan)

Contoh:

Chicken

pox

Vaksinasi

rubella


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NATURAL IMMUNITY (semulajadi)

1) Physical barrier (Perlindungan fizikal)

- skin- mucous membrane in respiratory

- hairs in the nasal tract

- lining cells of the intestinal tract


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2) Chemical barrier (perlindungan kimia)

- gastric juice

- saliva (air liur)

- sweat (peluh)

- tears- human milk


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3) Phagocytosis

- phagocyte cells engulf and destroy aninvading organism, cellular debris, toxin and

foreign body..

*phagocytic cells

- Neutrophil and macrophages


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4) Action of natural killer cells

- non-specific, non-phagocytic cells which candamage virus-infected tissue cells..

5) Action of bodys natural microbial flora

(bacteria normally found in certain part of the

body)

6) Influence by genetic factor


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Specific immune reaction against a foreign

antigen (invading organism, harmful cell ortoxic substance)

2 types of reaction

Humoral immune response (humoral)

Cell mediated immune response (sellular)

ACQUIRED IMMUNITY (perolehan)


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Humoral immune response

-Antibody produced by antigen stimulated immune cells(B-lymphocyte)

- Circulate in the blood

- Produce antibody to react specifically against the

specific antigen

Cell-mediated immune response

Immune cells (T-Lymphocyte and macrophages)directly attack intracellular pathogens, tumor cells and

foreign tissue


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Acquired Immunity

Active

Passive


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Active acquired immunity

recognized a foreign antigen

react specifically

destruction

inactivate

record information about it..


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Occurs when:

Naturally when the body exposed to infection

Artificially when a person is stimulated to produceantibodies (immunized or vaccinated against a

particular disease)


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Passive acquired immunity

Antibody that has been formed in another

person/animal are introduced into the body ofa non-immune person (antibody transfer)

Occurs when:

Naturally (from placenta to baby during

pregnancy, breast milk) Artificially (receive antitoxin/gammaglobulin in the

treatment)


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Natural (Non-specific)

Mechanical barrier Chemical barrier

Phagocytosis

Killer cells

Bodys natural microbial

flora Genetic factor

Acquired (Specific)

Pasive Transplacental/breast

milk

Antitoxin/gammaglobulin

Active

Infection

Immunization/vaccination

Kesimpulan


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end

(1) MLTHSC 1042 (Introduction to Immunology)

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