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1 15 The Genetic Basis of Complex Inheritance
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1 15 The Genetic Basis of Complex Inheritance. 2 Multifactorial Traits Multifactorial traits are determined by multiple genetic and environmental factors.

Mar 26, 2015

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Page 1: 1 15 The Genetic Basis of Complex Inheritance. 2 Multifactorial Traits Multifactorial traits are determined by multiple genetic and environmental factors.

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15The Genetic Basis of Complex Inheritance

Page 2: 1 15 The Genetic Basis of Complex Inheritance. 2 Multifactorial Traits Multifactorial traits are determined by multiple genetic and environmental factors.

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Multifactorial Traits

• Multifactorial traits are determined by multiple genetic and environmental factors acting together

• Multifactorial = complex traits = quantitative traits

• Most traits that vary in the population, including common human diseases with the genetic component, are complex traits

• Genetic architecture of a complex trait = specific effects and combined interactions of all genetic and environmental factors

Page 3: 1 15 The Genetic Basis of Complex Inheritance. 2 Multifactorial Traits Multifactorial traits are determined by multiple genetic and environmental factors.

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Quantitative Inheritance• Quantitative traits = phenotypes differ in quantity

rather than type (such as height)

• In a genetically heterogeneous population, genotypes are formed by segregation and recombination

• Variation in genotype can be eliminated by studying inbred lines = homozygous for most genes, or F1 progeny of inbred lines = uniformly heterozygous

• Complete elimination of environmental variation is impossible

Page 4: 1 15 The Genetic Basis of Complex Inheritance. 2 Multifactorial Traits Multifactorial traits are determined by multiple genetic and environmental factors.

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Quantitative Inheritance• Continuous traits = continuous gradation from

one phenotype to the next (height)

• Categorical traits = phenotype is determined by counting (hen’s eggs)

• Threshold traits = only two, or a few phenotypic classes, but their inheritance is determined by multiple genes and environment (adult-onset diabetes)

Page 5: 1 15 The Genetic Basis of Complex Inheritance. 2 Multifactorial Traits Multifactorial traits are determined by multiple genetic and environmental factors.

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Distributions• Distribution of a trait in a population = proportion

of individuals that have each of the possible phenotypes

• Mean = peak of distribution

x = ∑fixi /N

• Variance = spread of distribution estimated by squared deviation from the mean s2=∑fi(xi - x )/N-1

• Standard deviation = square root of the variances =√ s2

Page 6: 1 15 The Genetic Basis of Complex Inheritance. 2 Multifactorial Traits Multifactorial traits are determined by multiple genetic and environmental factors.

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Normal Distribution• Normal distribution = symmetrical curve produced

by data in which half points are above and half points are below mean

~68% of a population have a phenotype within one standard deviation (s) of the mean~95% - within 2 s~99.7% - within 3 s

• The distribution of a trait in a population implies nothing about its inheritance

Page 7: 1 15 The Genetic Basis of Complex Inheritance. 2 Multifactorial Traits Multifactorial traits are determined by multiple genetic and environmental factors.

7Fig. 15.5

Page 8: 1 15 The Genetic Basis of Complex Inheritance. 2 Multifactorial Traits Multifactorial traits are determined by multiple genetic and environmental factors.

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Phenotypic Variation• Variation of a trait can be separated into genetic and

environmental components

• Genotypic variance g2 = variation in phenotype caused

by differences in genotype

• Environmental variance e2 = variation in phenotype

caused by environment

• Total variance p2 = combined effects of genotypic and

environmental variance

p2 = g

2 + e2

Page 9: 1 15 The Genetic Basis of Complex Inheritance. 2 Multifactorial Traits Multifactorial traits are determined by multiple genetic and environmental factors.

9Fig. 15.9

Page 10: 1 15 The Genetic Basis of Complex Inheritance. 2 Multifactorial Traits Multifactorial traits are determined by multiple genetic and environmental factors.

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Phenotypic Variation• Genotype and environment can interact or they can

be associated

• Genotype-environment (G-E) interaction = environmental effects on phenotype differ according to genotype

• Genotype-by-sex interaction: same genotype produces different phenotype in males and females (distribution of height among women and men)

Page 11: 1 15 The Genetic Basis of Complex Inheritance. 2 Multifactorial Traits Multifactorial traits are determined by multiple genetic and environmental factors.

11Fig. 15.10

Page 12: 1 15 The Genetic Basis of Complex Inheritance. 2 Multifactorial Traits Multifactorial traits are determined by multiple genetic and environmental factors.

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Genetic Variation• Genotype-environment (G-E) association = certain

genotypes are preferentially associated with certain environments

• There is no genotypic variance in a genetically homogeneous population g

2 = 0

• When the number of genes affecting a quantitative trait is not too large, the number, n, of genes contributing to the trait is

n = D2/8g2

D = difference between parental strains

Page 13: 1 15 The Genetic Basis of Complex Inheritance. 2 Multifactorial Traits Multifactorial traits are determined by multiple genetic and environmental factors.

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Broad-Sense Heritability• Broad-sense heritability (H2) includes all genetic

effects combined

H2 = g2 / p

2 = g2 / g

2 + e2

• Knowledge of heritability is useful in plant and animal breeding because it can be used to predict the magnitude and speed of population improvement

Page 14: 1 15 The Genetic Basis of Complex Inheritance. 2 Multifactorial Traits Multifactorial traits are determined by multiple genetic and environmental factors.

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Heritability: Twin Studies• Twin studies are often used to assess genetic

effects on variation in a trait

• Identical twins arise from the splitting of a single fertilized egg = genetically identical

• Fraternal twins arise from two fertilized eggs = only half of the genes are identical

• Theoretically, the variance between identical twins would be equivalent to e

2 , and between fraternal twins - g

2/2 + e2

Page 15: 1 15 The Genetic Basis of Complex Inheritance. 2 Multifactorial Traits Multifactorial traits are determined by multiple genetic and environmental factors.

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Heritability: Twin StudiesPotential sources of error in twin studies of heritability:

– Genotype-environment interaction increases the variance in fraternal twins but not identical twins

– Frequent sharing of embryonic membranes by identical twins creates similar intrauterine environment

– Greater similarity in treatment of identical twins results in decreased environmental variance

– Different sexes can occur in fraternal but not identical twins

Page 16: 1 15 The Genetic Basis of Complex Inheritance. 2 Multifactorial Traits Multifactorial traits are determined by multiple genetic and environmental factors.

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Narrow-Sense Heritability • Narrow-sense heritability (h2) = proportion of the

variance in phenotype that is transmissible from parents to offspring

• Narrow-sense heritability can be used to predict changes in the population mean in with individual selection

h2 = (M’ - M)/(M* - M)

• In general, h2 < H2 . They are equal only when the alleles affecting the trait are additive in their effects = heterozygous phenotype is exactly intermediate between homozygous dominant and recessive

Page 17: 1 15 The Genetic Basis of Complex Inheritance. 2 Multifactorial Traits Multifactorial traits are determined by multiple genetic and environmental factors.

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Artificial Selection• Artificial selection =“managed evolution” = the

practice of selecting a group of organisms from a population to become the parents of the next generation

• h2 is usually the most important in artificial selection• Individual selection = each member of the population

to be selected is evaluated according to its individual phenotype

• Truncation point = arbitrary level of phenotype that determines which individuals will be used for breeding purposes

Page 18: 1 15 The Genetic Basis of Complex Inheritance. 2 Multifactorial Traits Multifactorial traits are determined by multiple genetic and environmental factors.

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Artificial SelectionThere are limits to the improvement that can be achieved by artificial selection:

• Selection limit at which successive generations show no further improvement can be reached because natural selection counteracts artificial selection due to indirect harmful effects of selected traits (weight at birth versus viability)

• Correlated response = effect of selection for one trait on a non-selected trait (number of eggs and their size)

Page 19: 1 15 The Genetic Basis of Complex Inheritance. 2 Multifactorial Traits Multifactorial traits are determined by multiple genetic and environmental factors.

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Inbreeding• Inbreeding can have harmful

effects• Inbreeding depression =

decrease in fitness due to harmful recessive alleles which become homozygous

• Heterosis = hybrid vigor refers to superior fitness of heterozygote; often used in agricultural crop production

Fig. 15.14

Page 20: 1 15 The Genetic Basis of Complex Inheritance. 2 Multifactorial Traits Multifactorial traits are determined by multiple genetic and environmental factors.

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Correlation Between Relatives• Genetic variation is revealed by correlations

between relatives

• Covariance (Cov), the tendency for traits to vary together, is Cov(x,y)=∑fi(xi - x )(yi - y )/N-1

• Correlation coefficient (r) = statistical evaluation of paired data (pairs of parents, twins, parent and offspring)

r =Cov(x,y)/sxsy

• Covariance and correlation coefficient are important in heritability estimates

Page 21: 1 15 The Genetic Basis of Complex Inheritance. 2 Multifactorial Traits Multifactorial traits are determined by multiple genetic and environmental factors.

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Correlation Between Relatives• Correlation

coefficient of a trait between relatives is related to the narrow- or broad-sense heritability

Page 22: 1 15 The Genetic Basis of Complex Inheritance. 2 Multifactorial Traits Multifactorial traits are determined by multiple genetic and environmental factors.

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Threshold Traits: Heritability• Liability = quantitative trait that presents a

genetic risk for a threshold trait

• Individuals with a liability above threshold develop the trait

• The risk of manifesting a threshold trait has H2 and h2 that cannot be estimated directly, but can be inferred from the incidents of the trait among individuals and their relatives

Page 23: 1 15 The Genetic Basis of Complex Inheritance. 2 Multifactorial Traits Multifactorial traits are determined by multiple genetic and environmental factors.

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Threshold Traits: Heritability• Many congenital abnormalities are inherited as

threshold traits

• Heritability analyses can be used to determine recurrence risks

• Theoretical curves show incidence, type of

inheritance and risk among first-degree relatives of an affected individual

Page 24: 1 15 The Genetic Basis of Complex Inheritance. 2 Multifactorial Traits Multifactorial traits are determined by multiple genetic and environmental factors.

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Multifactorial Disorders• Most common disorders in human families are

multifactorial• Pedigree studies of genetic polymorphisms

are used to map loci for quantitative traits• Quantitative trait locus (QTL) = gene that affects a

quantitative trait• Simple tandem repeat polymorphisms (STRPs) are

used to locate QTLs• Candidate gene = gene for which there is some a

priori basis for suspecting that it affects the trait